2ki6
The FGF1-S100A13-C2A hetero-hexameric complex structure: A component in the non-classical pathway for FGF1 secretion
SAXS 散射曲线 SAXS Profile
P(r) 距离分布 P(r) Distribution
1. 结构基本信息 1. Structure Basics
| 条目编号 entry_id | 2ki6 |
| 沉积日期 deposition_date | 2009-04-28 |
| 结构标题 title | The FGF1-S100A13-C2A hetero-hexameric complex structure: A component in the non-classical pathway for FGF1 secretion |
| 关键词 keywords | ;FGF1-S100A13-C2A hetero-hexameric complex, FGF1, S100A13, C2A, Calcium, Cell junction, Cytoplasmic vesicle, Glycoprotein, Lipoprotein, Membrane, Metal-binding, Palmitate, Phosphoprotein, Synapse, Transmembrane, Acetylation, Alternative splicing, Angiogenesis, Developmental protein, Differentiation, Growth factor, Heparin-binding, Mitogen, Polymorphism, PROTEIN TRANSPORT ;; PROTEIN TRANSPORT |
| 实验方法 method | SOLUTION NMR |
2. SAXS 参数 (CRYSOL 理论计算) 2. SAXS Parameters (CRYSOL)
| 回转半径 Rg (Guinier) rg_guinier | 31.03 Å |
| 回转半径 Rg (电子) rg_electron | 30.79 Å |
| 零角强度 I(0) i0 | 28771600000.00 |
| 分子量 molecular_weight | 1486900.0 kDa |
| 排除体积 excluded_volume | 1875000 ų |
| 包络体积 envelope_volume | 151290 ų |
| 水化壳体积 shell_volume | 40029 ų |
| 包络直径 envelope_diameter | 94.4 Å |
| 壳层 Rg shell_rg | 38.92 Å |
| 包络 Rg envelope_rg | 30.17 Å |
| 形状 Rg shape_rg | 30.78 Å |
| 总 Rg total_rg | 30.86 Å |
| 总原子数 total_atoms | 210150 |
| 残基数 n_residues | 12870 |
| 球谐函数阶数 n_harmonics | 20 |
| q 范围 q_range | — – 0.5000 Å−1 |
| 数据点数 n_points | 101 |
| 壳层类型 shell_type | directional |
| 溶剂电子密度 solvent_density | 0.3340 e/ų |
| 壳层衬度 contrast_shell | 0.0300 e/ų |
| CRYSOL 版本 crysol_version | 4.1.3 |
3. P(r) 距离分布 (GNOM 反演) 3. P(r) Analysis (GNOM)
| 最大尺寸 Dmax dmax | 81.5 Å |
| Rg (实空间) rg_real | 30.85 Å |
| Rg 误差 (实空间) rg_real_error | 0.46 Å |
| I(0) (实空间) i0_real | 2.8770e+10 |
| I(0) 误差 (实空间) i0_real_error | 4.3850e+08 |
| Rg (倒空间) rg_reciprocal | 30.93 Å |
| I(0) (倒空间) i0_reciprocal | 28770000000.0000 |
| 解质量估计 total_estimate | 0.8484 |
| 解质量评级 solution_quality | GOOD a GOOD solution |
| P(r) 峰数 n_peaks | 2 |
| 主峰位置 r_peak_primary | 40.0 Å |
| 偏度 Skewness skewness | 0.018 |
| 峰度 Kurtosis kurtosis | -0.776 |
| 角度范围 angular_range | — – 0.2550 Å−1 |
| 当前正则化参数 α current_alpha | 0.0000 |
| 最高正则化参数 α highest_alpha | 11410000.0000 |
| 实空间数据点数 n_real_points | 52 |
| GNOM 版本 gnom_version | 4.1.3 |
| 质量判据 quality_criteria | AN1: 0.000; Oscil: 1.000; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.992; Smooth: 0.033 |
4. 晶体学与实验 4. Crystallography & Experiment
5. 实体与聚合体信息 (4)
6. 折叠分类 (SCOP + CATH) 12 domains
SCOP 2.08 (6 domains)
| 结构域编号 domain_id | d2ki6a_ |
| 类 Class class | b — All beta proteins |
| 折叠类型 Fold fold | b.7 — C2 domain-like |
| 超家族 Superfamily superfamily | b.7.1 — C2 domain (Calcium/lipid-binding domain, CaLB) |
| 家族 Family family | b.7.1.2 — Synaptotagmin-like (S variant) |
| 结构域编号 domain_id | d2ki6b_ |
| 类 Class class | b — All beta proteins |
| 折叠类型 Fold fold | b.42 — beta-Trefoil |
| 超家族 Superfamily superfamily | b.42.1 — Cytokine |
| 家族 Family family | b.42.1.1 — Fibroblast growth factors (FGF) |
| 结构域编号 domain_id | d2ki6c_ |
| 类 Class class | a — All alpha proteins |
| 折叠类型 Fold fold | a.39 — EF Hand-like |
| 超家族 Superfamily superfamily | a.39.1 — EF-hand |
| 家族 Family family | a.39.1.0 — automated matches |
| 结构域编号 domain_id | d2ki6d_ |
| 类 Class class | a — All alpha proteins |
| 折叠类型 Fold fold | a.39 — EF Hand-like |
| 超家族 Superfamily superfamily | a.39.1 — EF-hand |
| 家族 Family family | a.39.1.0 — automated matches |
| 结构域编号 domain_id | d2ki6e_ |
| 类 Class class | b — All beta proteins |
| 折叠类型 Fold fold | b.42 — beta-Trefoil |
| 超家族 Superfamily superfamily | b.42.1 — Cytokine |
| 家族 Family family | b.42.1.1 — Fibroblast growth factors (FGF) |
| 结构域编号 domain_id | d2ki6f_ |
| 类 Class class | b — All beta proteins |
| 折叠类型 Fold fold | b.7 — C2 domain-like |
| 超家族 Superfamily superfamily | b.7.1 — C2 domain (Calcium/lipid-binding domain, CaLB) |
| 家族 Family family | b.7.1.2 — Synaptotagmin-like (S variant) |
CATH v4.4 (6 domains)
| 结构域编号 domain_id | 2ki6A00 |
| 类 Class class | 2 — Mainly Beta |
| 架构 Architecture architecture | 60 — Sandwich |
| 拓扑 Topology topology | 40 — Immunoglobulin-like |
| 同源超家族 H-superfamily homologous superfamily | 150 — C2 domain |
| 结构域编号 domain_id | 2ki6B00 |
| 类 Class class | 2 — Mainly Beta |
| 架构 Architecture architecture | 80 — Trefoil |
| 拓扑 Topology topology | 10 — Trefoil (Acidic Fibroblast Growth Factor, subunit A) |
| 同源超家族 H-superfamily homologous superfamily | 50 — |
| 结构域编号 domain_id | 2ki6C00 |
| 类 Class class | 1 — Mainly Alpha |
| 架构 Architecture architecture | 10 — Orthogonal Bundle |
| 拓扑 Topology topology | 238 — Recoverin; domain 1 |
| 同源超家族 H-superfamily homologous superfamily | 10 — EF-hand |
| 结构域编号 domain_id | 2ki6D00 |
| 类 Class class | 1 — Mainly Alpha |
| 架构 Architecture architecture | 10 — Orthogonal Bundle |
| 拓扑 Topology topology | 238 — Recoverin; domain 1 |
| 同源超家族 H-superfamily homologous superfamily | 10 — EF-hand |
| 结构域编号 domain_id | 2ki6E00 |
| 类 Class class | 2 — Mainly Beta |
| 架构 Architecture architecture | 80 — Trefoil |
| 拓扑 Topology topology | 10 — Trefoil (Acidic Fibroblast Growth Factor, subunit A) |
| 同源超家族 H-superfamily homologous superfamily | 50 — |
| 结构域编号 domain_id | 2ki6F00 |
| 类 Class class | 2 — Mainly Beta |
| 架构 Architecture architecture | 60 — Sandwich |
| 拓扑 Topology topology | 40 — Immunoglobulin-like |
| 同源超家族 H-superfamily homologous superfamily | 150 — C2 domain |