2l7u

Structure of CEL-PEP-RAGE V domain complex

Method: SOLUTION NMR D_max: 54.5 Å Quality: REASONABLE

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1. Protein Identity and Related Structures Protein Identity & Related Structures

Advanced glycosylation end product-specific receptor

Homo sapiens

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein heterocomplex Heteromer Protein × 2 PDB declaration: dimeric（2） Consistent with protein copy count	Chain A； UniProt 23–125	Fragment：Ig-like V-type domain residues 23-125	Serum albumin peptide × 1 （P02769）	SOLUTION NMR NMR measurement conditions：pH 6.5；298 K；Ionic strength (raw mmCIF value) 130；Pressure ambient NMR sample composition：0.1 mM [U-100% 13C; U-100% 15N] V domain, 0.3 mM CEL-PEP, 90% H2O/10% D2O \| 90% H2O/10% D2O NMR sample composition：0.32 mM [U-100% 13C; U-100% 15N] V domain, 1 mM CEL-PEP, 90% H2O/10% D2O \| 90% H2O/10% D2O	Resolution not provided

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB	Difference from Current Entry 2L7U	Assembly / Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Non-polymers	Method and Experimental Conditions	Structure Quality
2E5E Solution Structure of Variable-type Domain of Human Receptor for Advanced Glycation Endproducts Deposited 2006-12-20	Different construct Different oligomeric state Different experimental conditions	Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain A 23–121（99 aa） Fragment：VARIABLE-TYPE DOMAIN	Not recorded	No recorded non-water small molecule	SOLUTION NMR NMR measurement conditions pH 7.5；298 K；Pressure 1 NMR sample composition 0.2mM Variable-type Domain of Receptor for Advanced Glycation Endproducts U-15N, 13C; 20mM phosphate buffer NA, 100mM NA2SO4; 90% H2O, 10% D2O \| 90% H2O/10% D2O NMR sample composition 0.2mM Variable-type Domain of Receptor for Advanced Glycation Endproducts; 20mM phosphate buffer NA, 100mM NA2SO4; 100% D2O \| 100% D2O	Resolution not provided
2ENS Solution structure of the third ig-like domain from human Advanced glycosylation end product-specific receptor Deposited 2007-03-28	Different construct Different oligomeric state Different experimental conditions	Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain A 235–323（89 aa） Fragment：Ig-like domain, UNP residues 235-323	Not recorded	No recorded non-water small molecule	SOLUTION NMR NMR measurement conditions pH 7；296 K；Ionic strength (raw mmCIF value) 120mM；Pressure ambient NMR sample composition 1.17mM 13C,15N-laveled protein; 20mM d-Tris-HCl(pH7.0); 100mM NaCl; 1mM d-DTT; 0.02% NaN3; 90% H2O, 10% D2O \| 90% H2O/10% D2O	Resolution not provided
2LE9 RAGEC2-S100A13 tetrameric complex Deposited 2011-06-14	Different construct Different mutation/modification Different oligomeric state Different experimental conditions	Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric	Chain A 235–327（93 aa） Fragment：UNP RESIDUES 235-327 Chain D 235–327（93 aa） Fragment：UNP RESIDUES 235-327	Not recorded	No recorded non-water small molecule	SOLUTION NMR NMR measurement conditions pH 6.5；298 K；Ionic strength (raw mmCIF value) 100；Pressure ambient NMR measurement conditions pH 6.5；298 K；Ionic strength (raw mmCIF value) 100；Pressure ambient NMR sample composition 1.1 mM [U-100% 13C; U-100% 15N] entity_1-1, 1.1 mM entity_2-2, 25 mM sodium phosphate-3, 100 mM sodium chloride-4, 1 mM DTT-5, 0.02 mM sodium azide-6, 90% H2O/10% D2O \| 90% H2O/10% D2O NMR sample composition 1.2 mM entity_1-7, 1.2 mM [U-100% 13C; U-100% 15N] entity_2-8, 25 mM sodium phosphate-9, 100 mM sodium chloride-10, 1 mM DTT-11, 0.02 mM sodium azide-12, 90% H2O/10% D2O \| 90% H2O/10% D2O	Resolution not provided
2LMB Solution Structure of C-terminal RAGE (ctRAGE) Deposited 2011-11-29	Different construct Different oligomeric state Different experimental conditions	Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain A 363–404（42 aa） Fragment：residues 363-404	Not recorded	No recorded non-water small molecule	SOLUTION NMR NMR measurement conditions pH 6.5；298 K；Ionic strength (raw mmCIF value) 130；Pressure ambient NMR sample composition 300 uM [U-99% 13C; U-99% 15N] ctRAGE, 10 % [U-100% 2H] D2O, 10 mM potassium phosphate, 100 mM sodium chloride, 0.02 % sodium azide, 90% H2O/10% D2O \| 90% H2O/10% D2O	Resolution not provided
2M1K Interaction of Human S100A6 (C3S) with V domain of Receptor for Advanced Glycation End products (RAGE) Deposited 2012-11-29	Different construct Different mutation/modification Different oligomeric state Different experimental conditions	Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric	Chain A 23–121（99 aa） Fragment：UNP residues 23-121 Chain C 23–121（99 aa） Fragment：UNP residues 23-121	Not recorded	No recorded non-water small molecule	SOLUTION NMR NMR measurement conditions pH 7；298 K；Ionic strength (raw mmCIF value) 0；Pressure ambient NMR sample composition 1.0 mM [U-100% 13C; U-100% 15N] S100A6 C3S, 20 mM TRIS, 10 mM Calcium chloride, 0.01 % sodium azide, 90% H2O/10% D2O \| 90% H2O/10% D2O	Resolution not provided
2MJW Structural Insights into Calcium Bound S100P - V Domain of the receptor for advanced glycation end products (RAGE) Complex Deposited 2014-01-19	Different construct Different mutation/modification Different oligomeric state Different experimental conditions	Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric	Chain A 23–121（99 aa） Fragment：UNP RESIDUES 23-121 Chain C 23–121（99 aa） Fragment：UNP RESIDUES 23-121	Not recorded	No recorded non-water small molecule	SOLUTION NMR NMR measurement conditions pH 6.8；298 K；Ionic strength (raw mmCIF value) 0.1；Pressure ambient NMR sample composition 0.6 mM [U-100% 13C; U-100% 15N] entity_1-1, 0.6 mM [U-100% 13C; U-100% 15N] entity_2-2, 90% H2O/10% D2O \| 90% H2O/10% D2O	Resolution not provided
2MOV Receptor for Advanced Glycation End Products (RAGE) Specifically Recognizes Methylglyoxal Derived AGEs. Deposited 2014-05-05	Different construct Different oligomeric state Different ligand/ion Different experimental conditions	Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain A 23–125（103 aa） Fragment：UNP residues 23-125	Not recorded	IOR N~5~-[(5R)-5-methyl-4-oxo-4,5-dihydro-1H-imidazol-2-yl]-L-ornithine × 1	SOLUTION NMR NMR measurement conditions pH 6.5；298 K；Pressure ambient NMR sample composition 0.1 mM [U-13C; U-15N] Methylglyoxal-derived hydroimidazolones isoform 1, 90% H2O/10% D2O \| 90% H2O/10% D2O	Resolution not provided
3CJJ Crystal structure of human rage ligand-binding domain Deposited 2008-03-13	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain A 23–240（218 aa） Fragment：V and C1 domain, ligand-binding domain	Not recorded	ACT ACETATE ION × 1 ZN ZINC ION × 4	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；0.1M Na cacodylate, 0.2M Zn acetate, 11% PEG 8000, pH 6.5, vapor diffusion, hanging drop, temperature 298K	Resolution 1.85 Å R-free 0.240
3O3U Crystal Structure of Human Receptor for Advanced Glycation Endproducts (RAGE) Deposited 2010-07-26	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric	Chain N 23–231（209 aa） Fragment：MBP: UNP residues 28-384, RAGE: UNP residues 23-231	Not recorded	SO4 SULFATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；277 K；200 mM Li sulfate, 100 mM Tris-HCl, pH 7.5 and 10% (w/v) polyethylene glycol 4,000 , VAPOR DIFFUSION, HANGING DROP, temperature 277K	Resolution 1.50 Å R-free 0.184
4LP4 Crystal structure of the human RAGE VC1 fragment in space group P62 Deposited 2013-07-15	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain A 23–231（209 aa） Fragment：V and C1 domains (VC1 fragment), ectodomain fragment (UNP residues 23-231)	Not recorded	NA SODIUM ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；277 K；2.5 M sodium acetate, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K	Resolution 2.40 Å R-free 0.217
4LP4 Crystal structure of the human RAGE VC1 fragment in space group P62 Deposited 2013-07-15	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain B 23–231（209 aa） Fragment：V and C1 domains (VC1 fragment), ectodomain fragment (UNP residues 23-231)	Not recorded	NA SODIUM ION × 3	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；277 K；2.5 M sodium acetate, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K	Resolution 2.40 Å R-free 0.217
4LP5 Crystal structure of the full-length human RAGE extracellular domain (VC1C2 fragment) Deposited 2013-07-15	Different construct Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain B 23–323（301 aa） Fragment：V, C1 and C2 domains (VC1C2 fragment), full-length ectodomain (UNP residues 23-323)	Not recorded	No recorded non-water small molecule	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8；277 K；0.1 M Tris, 10% Ethanol, pH 8.0, VAPOR DIFFUSION, HANGING DROP, temperature 277K	Resolution 3.80 Å R-free 0.286
4LP5 Crystal structure of the full-length human RAGE extracellular domain (VC1C2 fragment) Deposited 2013-07-15	Different construct Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain A 23–323（301 aa） Fragment：V, C1 and C2 domains (VC1C2 fragment), full-length ectodomain (UNP residues 23-323)	Not recorded	No recorded non-water small molecule	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8；277 K；0.1 M Tris, 10% Ethanol, pH 8.0, VAPOR DIFFUSION, HANGING DROP, temperature 277K	Resolution 3.80 Å R-free 0.286
4OF5 Refinement of RAGE-DNA complex in 3S59 without DNA Deposited 2014-01-14	Different construct Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain A 23–237（215 aa） Fragment：VC1 fragment	Not recorded	No recorded non-water small molecule	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.4；298 K；10% PEG6000, 0.1 M Tris_HCl pH 7.4, VAPOR DIFFUSION, HANGING DROP, temperature 298K	Resolution 2.80 Å R-free 0.235
4OF5 Refinement of RAGE-DNA complex in 3S59 without DNA Deposited 2014-01-14	Different construct Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain B 23–237（215 aa） Fragment：VC1 fragment	Not recorded	No recorded non-water small molecule	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.4；298 K；10% PEG6000, 0.1 M Tris_HCl pH 7.4, VAPOR DIFFUSION, HANGING DROP, temperature 298K	Resolution 2.80 Å R-free 0.235
4OFV Refinement of RAGE-DNA complex in 3S58 without DNA Deposited 2014-01-15	Different construct Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain A 23–235（213 aa） Fragment：VC1 fragment	Not recorded	No recorded non-water small molecule	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION；pH 7.4；298 K；12% PEG6000, 0.1 M Tris-HCl, pH 7.4, VAPOR DIFFUSION, HANGING DROP, temperature 298K	Resolution 3.10 Å R-free 0.240
4OFV Refinement of RAGE-DNA complex in 3S58 without DNA Deposited 2014-01-15	Different construct Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain B 23–235（213 aa） Fragment：VC1 fragment	Not recorded	No recorded non-water small molecule	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION；pH 7.4；298 K；12% PEG6000, 0.1 M Tris-HCl, pH 7.4, VAPOR DIFFUSION, HANGING DROP, temperature 298K	Resolution 3.10 Å R-free 0.240
4OI7 RAGE recognizes nucleic acids and promotes inflammatory responses to DNA Deposited 2014-01-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein–DNA Homooligomer；Protein × 2 PDB declaration: tetrameric	Chain A 23–237（215 aa） Fragment：UNP residues 23-237 Chain B 23–237（215 aa） Fragment：UNP residues 23-237	Not recorded	EDO 1,2-ETHANEDIOL × 4	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.4；298 K；12% PEG6000, 0.1 M Tris-HCl, pH 7.4, VAPOR DIFFUSION, HANGING DROP, temperature 298K	Resolution 3.10 Å R-free 0.237
4OI8 RAGE is a nucleic acid receptor that promotes inflammatory responses to DNA. Deposited 2014-01-19	Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein–DNA Homooligomer；Protein × 2 PDB declaration: tetrameric	Chain A 23–237（215 aa） Fragment：UNP residues 23-237 Chain B 23–237（215 aa） Fragment：UNP residues 23-237	Not recorded	No recorded non-water small molecule	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.4；298 K；0.1 M HEPES, pH 7.4, 5% PEG6000, 5% isopropanol, VAPOR DIFFUSION, HANGING DROP, temperature 298K	Resolution 3.10 Å R-free 0.267
4P2Y Crystal structure of the human RAGE ectodomain (fragment VC1C2) in complex with mouse S100A6 Deposited 2014-03-05	Different construct Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric	Chain A 23–323（301 aa） Fragment：V, C1 and C2 domains (VC1C2 module), full-length ectodomain, UNP residues 23-323	Not recorded	ZN ZINC ION × 6 CL CHLORIDE ION × 6 ACT ACETATE ION × 7 CA CALCIUM ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；0.2 M Zn acetate, 0.1 M Na cacodylate pH 6.5, 10% isopropanol	Resolution 2.30 Å R-free 0.207
4P2Y Crystal structure of the human RAGE ectodomain (fragment VC1C2) in complex with mouse S100A6 Deposited 2014-03-05	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric	Chain A 23–323（301 aa） Fragment：V, C1 and C2 domains (VC1C2 module), full-length ectodomain, UNP residues 23-323	Not recorded	ZN ZINC ION × 24 CL CHLORIDE ION × 24 ACT ACETATE ION × 28 CA CALCIUM ION × 8	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；0.2 M Zn acetate, 0.1 M Na cacodylate pH 6.5, 10% isopropanol	Resolution 2.30 Å R-free 0.207
4P2Y Crystal structure of the human RAGE ectodomain (fragment VC1C2) in complex with mouse S100A6 Deposited 2014-03-05	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 3 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric	Chain A 23–323（301 aa） Fragment：V, C1 and C2 domains (VC1C2 module), full-length ectodomain, UNP residues 23-323	Not recorded	ZN ZINC ION × 12 CL CHLORIDE ION × 12 ACT ACETATE ION × 14 CA CALCIUM ION × 4	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；0.2 M Zn acetate, 0.1 M Na cacodylate pH 6.5, 10% isopropanol	Resolution 2.30 Å R-free 0.207
4YBH Crystal structure of the human RAGE ectodomain (VC1C2 fragment) in complex with human S100A6 Deposited 2015-02-18	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric	Chain A 23–323（301 aa） Fragment：V, C1 and C2 domains (VC1C2 module), full-length ectodomain, UNP residues 23-323	Not recorded	ZN ZINC ION × 14 CL CHLORIDE ION × 10 ACT ACETATE ION × 6 CA CALCIUM ION × 4	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；0.2 M Zn acetate, 0.1 M Na cacodylate pH 6.5, 10% isopropanol	Resolution 2.40 Å R-free 0.233
5D7F X-ray structure of Ca(2+)-S100B with human RAGE-derived W72 peptide Deposited 2015-08-13	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric	Chain P 65–79（15 aa）	Not recorded	CA CALCIUM ION × 4 GOL GLYCEROL × 6	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.8；293 K；100mM Na cacodylate pH 6.8, 22% w/v PEG 3350, 5mM CaCl2	Resolution 1.30 Å R-free 0.183
6VXG Structure of the C-terminal Domain of RAGE and Its Inhibitor Deposited 2020-02-21	Different construct Different oligomeric state Different ligand/ion Different experimental conditions	Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain A 363–404（42 aa） Fragment：C-terminal residues 363-404	Not recorded	RQV N-(4-{7-cyano-4-[(morpholin-4-yl)methyl]quinolin-2-yl}phenyl)acetamide × 1	SOLUTION NMR NMR measurement conditions pH 7；298 K；Ionic strength (raw mmCIF value) 10；Pressure 1 NMR sample composition 300 uM [U-100% 13C; U-100% 15N] C-terminal RAGE, 90% H2O/10% D2O \| 90% H2O/10% D2O	Resolution not provided
6XQ1 Receptor for Advanced Glycation End Products VC1 domain in complex with 3-(3-((4-(4-carboxyphenoxy)benzyl)oxy)phenyl)-1H-indole-2-carboxylic acid Deposited 2020-07-09	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric	Chain A 23–231（209 aa） Fragment：VC1 domain, resdues 23-231 Chain B 23–231（209 aa） Fragment：VC1 domain, resdues 23-231	Not recorded	ACT ACETATE ION × 14 CL CHLORIDE ION × 4 V74 3-[3-({[3-(4-carboxyphenoxy)phenyl]methoxy}methyl)phenyl]-1H-indole-2-carboxylic acid × 4	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；277 K；2.5 M NaOAc (pH 7.5)	Resolution 1.51 Å R-free 0.197
6XQ3 Receptor for Advanced Glycation End Products VC1 domain in complex with 3-(3-(((3-(4-Carboxyphenoxy)benzyl)oxy)methyl)phenyl)-1H-indole-2-carboxylic acid Deposited 2020-07-09	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric	Chain A 23–231（209 aa） Fragment：VC1 domain, resdues 23-231 Chain B 23–231（209 aa） Fragment：VC1 domain, resdues 23-231	Not recorded	ACT ACETATE ION × 8 CL CHLORIDE ION × 4 V6Y 3-(3-{[3-(4-carboxyphenoxy)phenyl]methoxy}phenyl)-1H-indole-2-carboxylic acid × 8	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；277 K；2.5 M NaOAc (pH 7.5)	Resolution 1.71 Å R-free 0.220
6XQ5 Receptor for Advanced Glycation End Products VC1 domain in complex with Fragment 1 Deposited 2020-07-09	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric	Chain A 23–231（209 aa） Fragment：VC1 domain, resdues 23-231 Chain B 23–231（209 aa） Fragment：VC1 domain, resdues 23-231	Not recorded	ACT ACETATE ION × 14 CL CHLORIDE ION × 4 V6M 7-methyl-3-phenyl-1H-indole-2-carboxylic acid × 4	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；277 K；2.5 M NaOAc (pH 7.5)	Resolution 1.80 Å R-free 0.196
6XQ6 Receptor for Advanced Glycation End Products VC1 domain in complex with Fragment 11 Deposited 2020-07-09	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric	Chain A 23–231（209 aa） Fragment：VC1 domain, resdues 23-231 Chain B 23–231（209 aa） Fragment：VC1 domain, resdues 23-231	Not recorded	ACT ACETATE ION × 14 CL CHLORIDE ION × 4 V6P 3-phenoxyphenol × 6	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；277 K；2.5 M NaOAc (pH 7.5)	Resolution 1.90 Å R-free 0.221
6XQ7 Receptor for Advanced Glycation End Products VC1 domain in complex with Fragment 5 Deposited 2020-07-09	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric	Chain A 23–231（209 aa） Fragment：VC1 domain, resdues 23-231 Chain B 23–231（209 aa） Fragment：VC1 domain, resdues 23-231	Not recorded	ACT ACETATE ION × 18 V6V 5-bromo-3-methyl-1H-indole-2-carboxylic acid × 14 CL CHLORIDE ION × 4	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；277 K；2.5 M NaOAc (pH 7.5)	Resolution 1.80 Å R-free 0.222
6XQ8 Receptor for Advanced Glycation End Products VC1 domain in complex with Fragments 1 & 11 Deposited 2020-07-09	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric	Chain A 23–231（209 aa） Fragment：VC1 domain, resdues 23-231 Chain B 23–231（209 aa） Fragment：VC1 domain, resdues 23-231	Not recorded	ACT ACETATE ION × 12 V6M 7-methyl-3-phenyl-1H-indole-2-carboxylic acid × 4 V6P 3-phenoxyphenol × 6 CL CHLORIDE ION × 4	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；277 K；2.5 M NaOAc (pH 7.5)	Resolution 1.82 Å R-free 0.218
6XQ9 Receptor for Advanced Glycation End Products VC1 domain in complex with Fragments 1 & 13 Deposited 2020-07-09	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain A 23–231（209 aa） Fragment：VC1 domain, resdues 23-231	Not recorded	ACT ACETATE ION × 2 V6S 4-(3-hydroxyphenoxy)benzoic acid × 2 V6M 7-methyl-3-phenyl-1H-indole-2-carboxylic acid × 1	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；277 K；2.5 M NaOAc (pH 7.5)	Resolution 2.30 Å R-free 0.239
6XQ9 Receptor for Advanced Glycation End Products VC1 domain in complex with Fragments 1 & 13 Deposited 2020-07-09	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain B 23–231（209 aa） Fragment：VC1 domain, resdues 23-231	Not recorded	ACT ACETATE ION × 2 V6S 4-(3-hydroxyphenoxy)benzoic acid × 2 V6M 7-methyl-3-phenyl-1H-indole-2-carboxylic acid × 1	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；277 K；2.5 M NaOAc (pH 7.5)	Resolution 2.30 Å R-free 0.239
7LML Receptor for Advanced Glycation End Products VC1 domain in complex with 3-(3-(((3-(4-Carboxyphenoxy)benzyl)oxy)methyl)phenyl)-1H-indole-2-carboxylic acid Deposited 2021-02-05	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric	Chain A 23–231（209 aa） Fragment：VC1 domain, resdues 23-231 Chain B 23–231（209 aa） Fragment：VC1 domain, resdues 23-231	Not recorded	ACT ACETATE ION × 6 CL CHLORIDE ION × 2 Y6S 6-iodanyl-1~{H}-indole-2-carboxylic acid × 8	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；277 K；2.5 M NaOAc (pH 7.5)	Resolution 2.15 Å R-free 0.235
7LMW Receptor for Advanced Glycation End Products VC1 domain in complex with 3-(3-((4-(4-carboxyphenoxy)benzyl)oxy)phenyl)-1H-indole-2-carboxylic acid Deposited 2021-02-06	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric	Chain A 23–231（209 aa） Fragment：VC1 domain, resdues 23-231 Chain B 23–231（209 aa） Fragment：VC1 domain, resdues 23-231	Not recorded	Y6P 7-methyl-3-(1~{H}-pyrazol-4-yl)-1~{H}-indole-2-carboxylic acid × 6 ACT ACETATE ION × 5 CL CHLORIDE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；277 K；2.5 M NaOAc (pH 7.5)	Resolution 2.50 Å R-free 0.256
8I9M The RAGE and HMGB1 complex Deposited 2023-02-07	Different construct Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric	Chain B 23–233（211 aa）	Not recorded	No recorded non-water small molecule	ELECTRON MICROSCOPY cryo-EM buffer pH 8 cryo-EM vitrification conditions Cryogen NITROGEN	Resolution 5.19 Å
9D36 Structure of the C-terminal Domain of RAGE and Its Inhibitor Deposited 2024-08-09	Different construct Different oligomeric state Different ligand/ion Different experimental conditions	Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain A 362–404（43 aa）	Not recorded	A1A2E 4-[(morpholin-4-yl)methyl]-2-{4-[(2R)-5-oxopyrrolidin-2-yl]phenyl}quinoline-7-carbonitrile × 1	SOLUTION NMR NMR measurement conditions pH 6.5；298 K；Ionic strength (raw mmCIF value) 60；Pressure 1 NMR sample composition 40 uM [U-13C; U-15N] ctRAGE, 100 uM RAGE406R, 90% H2O/10% D2O \| 90% H2O/10% D2O NMR sample composition 40 uM [U-13C; U-15N] ctRAGE, 90% H2O/10% D2O \| 90% H2O/10% D2O	Resolution not provided
9S2X Crystal structure of the human RAGE ectodomain in complex with murine S100A6 mutant Y84C Deposited 2025-07-23	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric	Chain A 23–323（301 aa） Fragment：V, C1 and C2 domains (VC1C2 module), full-length ectodomain, UNP residues 23-323	Not recorded	ZN ZINC ION × 12 CL CHLORIDE ION × 8 ACT ACETATE ION × 8 CA CALCIUM ION × 4 NA SODIUM ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.5；277 K；0.2 M Zn acetate, 0.1 M Na cacodylate pH 6.5, 9% isopropanol	Resolution 2.35 Å R-free 0.235

31 other PDB entries and 38 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence

UniProt name	RAGE_HUMAN
Isoform	—
PDB entities	1
Chains and sequence ranges	Author chain A； PDBConstruct 3–105； UniProt 23–125

Serum albumin peptide

OrganismNot specified

UniProt P02769

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein heterocomplex Heteromer Protein × 2 PDB declaration: dimeric（2） Consistent with protein copy count	Chain B； UniProt 148–154	Fragment：Sequence database residues 148-154 Non-standard monomer：Yes (specific site not provided by mmCIF)	Advanced glycosylation end product-specific receptor × 1 （Q15109）	SOLUTION NMR NMR measurement conditions：pH 6.5；298 K；Ionic strength (raw mmCIF value) 130；Pressure ambient NMR sample composition：0.1 mM [U-100% 13C; U-100% 15N] V domain, 0.3 mM CEL-PEP, 90% H2O/10% D2O \| 90% H2O/10% D2O NMR sample composition：0.32 mM [U-100% 13C; U-100% 15N] V domain, 1 mM CEL-PEP, 90% H2O/10% D2O \| 90% H2O/10% D2O	Resolution not provided

Other States of the Same Protein in the Database

Other PDB	Difference from Current Entry 2L7U	Assembly / Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Non-polymers	Method and Experimental Conditions	Structure Quality
3V03 Crystal structure of Bovine Serum Albumin Deposited 2011-12-07	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain A 25–607（583 aa）	Not recorded	CA CALCIUM ION × 3	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；289 K；0.2 M Ca acetate, 20% PEG3350, 0.1 M Tris HCl, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 289K	Resolution 2.70 Å R-free 0.256
3V03 Crystal structure of Bovine Serum Albumin Deposited 2011-12-07	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain B 25–607（583 aa）	Not recorded	CA CALCIUM ION × 3 ACT ACETATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；289 K；0.2 M Ca acetate, 20% PEG3350, 0.1 M Tris HCl, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 289K	Resolution 2.70 Å R-free 0.256
4F5S Crystal Structure of Bovine Serum Albumin Deposited 2012-05-13	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain A 25–607（583 aa） Fragment：Mature form of BSA, UNP residues 25-607	Not recorded	PGE TRIETHYLENE GLYCOL × 1	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；20% mmePEG 5000, 0.25M ammonium chloride, 0.1M MES 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K	Resolution 2.47 Å R-free 0.259
4F5S Crystal Structure of Bovine Serum Albumin Deposited 2012-05-13	Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain B 25–607（583 aa） Fragment：Mature form of BSA, UNP residues 25-607	Not recorded	No recorded non-water small molecule	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；20% mmePEG 5000, 0.25M ammonium chloride, 0.1M MES 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K	Resolution 2.47 Å R-free 0.259
4JK4 Crystal Structure of Bovine Serum Albumin in complex with 3,5-diiodosalicylic acid Deposited 2013-03-09	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain A 25–607（583 aa） Fragment：UNP residues 25-607	Not recorded	DIU 2-HYDROXY-3,5-DIIODO-BENZOIC ACID × 4 PEG DI(HYDROXYETHYL)ETHER × 1 1PE PENTAETHYLENE GLYCOL × 2 PGE TRIETHYLENE GLYCOL × 1 CA CALCIUM ION × 4	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；22% MMEPEG 5000, 0.2M Calcium acetate, 0.1M MES 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K	Resolution 2.65 Å R-free 0.246
4JK4 Crystal Structure of Bovine Serum Albumin in complex with 3,5-diiodosalicylic acid Deposited 2013-03-09	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain B 25–607（583 aa） Fragment：UNP residues 25-607	Not recorded	DIU 2-HYDROXY-3,5-DIIODO-BENZOIC ACID × 4 PEG DI(HYDROXYETHYL)ETHER × 1 1PE PENTAETHYLENE GLYCOL × 1 PGE TRIETHYLENE GLYCOL × 1 CA CALCIUM ION × 3	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；22% MMEPEG 5000, 0.2M Calcium acetate, 0.1M MES 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K	Resolution 2.65 Å R-free 0.246
4OR0 Crystal Structure of Bovine Serum Albumin in complex with naproxen Deposited 2014-02-10	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain A 25–607（583 aa） Fragment：Mature form of BSA	Not recorded	NPS (2S)-2-(6-methoxynaphthalen-2-yl)propanoic acid × 3 PGE TRIETHYLENE GLYCOL × 1 PEG DI(HYDROXYETHYL)ETHER × 1	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；18% MMEPEG 5000, 0.2M ammonium chloride, 0.1M MES 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K	Resolution 2.58 Å R-free 0.257
4OR0 Crystal Structure of Bovine Serum Albumin in complex with naproxen Deposited 2014-02-10	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain B 25–607（583 aa） Fragment：Mature form of BSA	Not recorded	NPS (2S)-2-(6-methoxynaphthalen-2-yl)propanoic acid × 3	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；18% MMEPEG 5000, 0.2M ammonium chloride, 0.1M MES 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K	Resolution 2.58 Å R-free 0.257
6QS9 Bovine Serum Albumin in complex with Ketoprofen Deposited 2019-02-20	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric	Chain A 1–607（607 aa） Chain B 1–607（607 aa）	Not recorded	JGE (R)-Ketoprofen × 2 CA CALCIUM ION × 4	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；18% MMEPEG 5000, 0.2M ammonium chloride, 0.1M MES pH 6.5	Resolution 2.80 Å R-free 0.272
6RJV The X-ray structure of the Gold/Serum Albumin adduct obtained upon reaction of the protein with AuL12, a gold(III) dithiocarbamate complex Deposited 2019-04-29	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain A 25–607（583 aa）	Not recorded	MG MAGNESIUM ION × 1 AU GOLD ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.5；293 K；20% PEG3350 0.1 M Tris HCl pH 8.5 0.2 M MgCl2	Resolution 3.21 Å R-free 0.253
6RJV The X-ray structure of the Gold/Serum Albumin adduct obtained upon reaction of the protein with AuL12, a gold(III) dithiocarbamate complex Deposited 2019-04-29	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain B 25–607（583 aa）	Not recorded	MG MAGNESIUM ION × 1 AU GOLD ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.5；293 K；20% PEG3350 0.1 M Tris HCl pH 8.5 0.2 M MgCl2	Resolution 3.21 Å R-free 0.253
8KFO Crystal structure of BSA in complex with B3 Deposited 2023-08-16	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain A 1–607（607 aa）	Not recorded	OP6 6-[(~{E})-2-[1-[2-[2-(2-methoxyethoxy)ethoxy]ethyl]pyridin-1-ium-4-yl]ethenyl]-~{N},~{N}-dimethyl-naphthalen-2-amine × 2	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION；291.15 K；0.2M CaAC2, 22% PEG3350, 0.1M Tris pH 6.0	Resolution 3.60 Å R-free 0.316
8KFO Crystal structure of BSA in complex with B3 Deposited 2023-08-16	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain B 1–607（607 aa）	Not recorded	OP6 6-[(~{E})-2-[1-[2-[2-(2-methoxyethoxy)ethoxy]ethyl]pyridin-1-ium-4-yl]ethenyl]-~{N},~{N}-dimethyl-naphthalen-2-amine × 3	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION；291.15 K；0.2M CaAC2, 22% PEG3350, 0.1M Tris pH 6.0	Resolution 3.60 Å R-free 0.316
8WDD Crystal structure of BSA in complex with B1 Deposited 2023-09-14	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain A 25–607（583 aa）	Not recorded	VZK ~{N},~{N}-dimethyl-6-[(~{E})-2-(1-methylpyridin-1-ium-4-yl)ethenyl]naphthalen-2-amine × 3	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION；291.15 K；0.2M CaAC2, 22% PEG3350, 0.1M Tris pH6.0	Resolution 3.90 Å R-free 0.370
8WDD Crystal structure of BSA in complex with B1 Deposited 2023-09-14	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain B 25–607（583 aa）	Not recorded	VZK ~{N},~{N}-dimethyl-6-[(~{E})-2-(1-methylpyridin-1-ium-4-yl)ethenyl]naphthalen-2-amine × 6	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION；291.15 K；0.2M CaAC2, 22% PEG3350, 0.1M Tris pH6.0	Resolution 3.90 Å R-free 0.370
9QQD cryoEM structure of Bovine Serum Albumin Deposited 2025-03-31	Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain A 28–605（578 aa）	Not recorded	No recorded non-water small molecule	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.10 Å

9 other PDB entries and 16 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence

UniProt name	ALBU_BOVIN
Isoform	—
PDB entities	2
Chains and sequence ranges	Author chain B； PDBConstruct 1–7； UniProt 148–154

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

SAXS scattering curve SAXS Profile

P(r) Distance Distribution P(r) Distribution

Download Download SAXS (.dat) P(r) (.pr.out) CIF

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2. Structure Basics 2. Structure Basics

Entry ID entry_id	2l7u
Deposition date deposition_date	2010-12-23
Structure title title	Structure of CEL-PEP-RAGE V domain complex
Keywords keywords	V domain, Allergen, Cleavage on pair of basic residues, Lipid-binding, Metal-binding, Phosphoprotein, Secreted; ALLERGEN
Experimental Method method	SOLUTION NMR

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3. SAXS Parameters (CRYSOL theoretical calculation) 3. SAXS Parameters (CRYSOL)

Radius of gyration Rg (Guinier) rg_guinier	14.66 Å
Radius of gyration Rg (electron density) rg_electron	14.52 Å
Forward intensity I(0) i0	1362190000.00
Molecular weight molecular_weight	311230.0 kDa
Excluded volume excluded_volume	389120 Å³
Envelope volume envelope_volume	30401 Å³
Hydration-shell volume shell_volume	15370 Å³
Envelope diameter envelope_diameter	64.2 Å
Shell Rg shell_rg	22.88 Å
Envelope Rg envelope_rg	17.72 Å
Shape Rg shape_rg	14.49 Å
Total Rg total_rg	14.74 Å
Total atoms total_atoms	40000
Residues n_residues	2775
Spherical-harmonic order n_harmonics	20
q range q_range	— – 0.5000 Å⁻¹
Data points n_points	101
Shell type shell_type	directional
Solvent electron density solvent_density	0.3340 e/Å³
Shell contrast contrast_shell	0.0300 e/Å³
CRYSOL version crysol_version	4.1.3

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4. P(r) Distance Distribution (GNOM inversion) 4. P(r) Analysis (GNOM)

Maximum dimension Dmax dmax	54.5 Å
Rg (real space) rg_real	14.69 Å
Rg uncertainty (real space) rg_real_error	0.47 Å
I(0) (real space) i0_real	1.3620e+09
I(0) uncertainty (real space) i0_real_error	1.8100e+07
Rg (reciprocal space) rg_reciprocal	14.68 Å
I(0) (reciprocal space) i0_reciprocal	1362000000.0000
Solution quality estimate total_estimate	0.7367
Solution quality rating solution_quality	REASONABLE a REASONABLE solution
P(r) peaks n_peaks	3
Primary peak position r_peak_primary	17.9 Å
Skewness Skewness skewness	0.449
Kurtosis Kurtosis kurtosis	0.179
Angular range angular_range	— – 0.5000 Å⁻¹
Current regularization parameter α current_alpha	0.0000
Highest regularization parameter α highest_alpha	314800.0000
Real-space data points n_real_points	80
GNOM version gnom_version	4.1.3
Quality Criteria quality_criteria	AN1: 0.000; Oscil: 0.572; Stabil: 0.999; Sysdev: 1.000; Positv: 1.000; Valcen: 0.858; Smooth: 0.000

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5. Crystallography and Experiment 5. Crystallography & Experiment

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6. Entities and Polymers Entities & Polymers (2)

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7. Fold Classification (SCOP + CATH) 1 domains

CATH v4.4 (1 domains)

Domain ID domain_id	2l7uA00
Class class	2 — Mainly Beta
Architecture architecture	60 — Sandwich
Topology topology	40 — Immunoglobulin-like
Homologous superfamily homologous superfamily	10 — Immunoglobulins

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8. Citations (1)

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Description description	Advanced glycosylation end product-specific receptor
Molecular weight formula_weight	11571.3 kDa
Source method src_method	man
Copy count entity_count	1

Polymer type type	polypeptide(L)
Chain IDs strand_id	A
Atom count atom_count	40000

来源生物 organism	Homo sapiens
通用名 common_name	human
NCBI Class编号 ncbi_taxonomy_id	9606
宿主生物 host_organism	Escherichia coli

Description description	Serum albumin peptide
Molecular weight formula_weight	922.9 kDa
Source method src_method	syn
Copy count entity_count	1

fit	/app/data/saxs_computation/l7/2l7u/2l7u.fit
pddf	/app/data/pr_computation/l7/2l7u/2l7u.pr.out
profile	/app/data/saxs_computation/l7/2l7u/2l7u.dat

Structure of CEL-PEP-RAGE V domain complex

1. Protein Identity and Related Structures Protein Identity & Related Structures

Advanced glycosylation end product-specific receptor

State in the Current Structure

Other States of the Same Protein in the Database

Serum albumin peptide

State in the Current Structure

Other States of the Same Protein in the Database

SAXS scattering curve SAXS Profile

P(r) Distance Distribution P(r) Distribution

2. Structure Basics 2. Structure Basics

3. SAXS Parameters (CRYSOL theoretical calculation) 3. SAXS Parameters (CRYSOL)

4. P(r) Distance Distribution (GNOM inversion) 4. P(r) Analysis (GNOM)

5. Crystallography and Experiment 5. Crystallography & Experiment

6. Entities and Polymers Entities & Polymers (2)

Entity 1 Entity 1 polymer

Polymer Polymer

来源 Source

Entity 2 Entity 2 polymer

Polymer Polymer

7. Fold Classification (SCOP + CATH) 1 domains

CATH v4.4 (1 domains)

8. Citations (1)

9. Files and Curves (10)

Files (7)

Curves (3)