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2p7a

Crystal Structure of Estrogen Related Receptor g in complex with 3-methyl phenol

Method: X-RAY DIFFRACTION Dmax: 60.0 Å Quality: GOOD
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Estrogen-related receptor gamma

Homo sapiens

UniProt P62508

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein monomer Monomer Protein × 1 PDB declaration: monomeric（1） Consistent with protein copy count Chain A； UniProt 229–458 Not recorded 43M 4-CHLORO-3-METHYLPHENOL × 1 X-RAY DIFFRACTION X-ray crystallization conditions：VAPOR DIFFUSION, HANGING DROP；pH 8.5；277 K；22.6% polyethylene glycol 4000, 0.1M Tris pH 8.5 and 0.2M Sodium acetate, VAPOR DIFFUSION, HANGING DROP, temperature 277K Resolution 2.30 Å R-free 0.256

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 2P7A Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
1KV6 X-ray structure of the orphan nuclear receptor ERR3 ligand-binding domain in the constitutively active conformation Deposited 2002-01-25 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 229–458（230 aa） Fragment：ligand-binding domain
Chain B 229–458（230 aa） Fragment：ligand-binding domain
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8；277 K；Tris.HCl, ammonium sulfate, glycerol, pH 8.0, VAPOR DIFFUSION, HANGING DROP at 277K
Resolution 2.70 Å R-free 0.267
1TFC CRYSTAL STRUCTURE OF THE LIGAND-BINDING DOMAIN OF THE ESTROGEN-RELATED RECEPTOR GAMMA IN COMPLEX WITH A STEROID RECEPTOR COACTIVATOR-1 PEPTIDE Deposited 2004-05-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 229–458（230 aa） Fragment：LIGAND-BINDING DOMAIN
Chain B 229–458（230 aa） Fragment：LIGAND-BINDING DOMAIN
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.5；277 K；TRIS.HCL, AMMONIUM SULFATE, GLYCEROL, pH 8.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
Resolution 2.40 Å R-free 0.258
2E2R Crystal structure of human estrogen-related receptor gamma ligand binding domain complex with bisphenol A Deposited 2006-11-16 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 222–458（237 aa） Fragment：ligand binding domain, residues 232-459
Not recorded 2OH 4,4'-PROPANE-2,2-DIYLDIPHENOL × 2 GOL GLYCEROL × 6 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；293 K；0.05M HEPES, 0.75M sodium citrate, 5% glycerol, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 1.60 Å R-free 0.197
2EWP Crystal structure of Estrogen Related Receptor-3 (ERR-gamma) ligand binding domaind with tamoxifen analog GSK5182 Deposited 2005-11-04 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 233–458（226 aa）
Chain B 233–458（226 aa）
Not recorded TXF (Z)-4-(1-{4-[2-(DIMETHYLAMINO)ETHOXY]PHENYL}-5-HYDROXY-2-PHENYLPENT-1-ENYL)PHENOL × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；0.2M sodium Citrate, 20% PEG3350, VAPOR DIFFUSION, HANGING DROP
Resolution 2.30 Å R-free 0.247
2EWP Crystal structure of Estrogen Related Receptor-3 (ERR-gamma) ligand binding domaind with tamoxifen analog GSK5182 Deposited 2005-11-04 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain C 233–458（226 aa）
Chain D 233–458（226 aa）
Not recorded TXF (Z)-4-(1-{4-[2-(DIMETHYLAMINO)ETHOXY]PHENYL}-5-HYDROXY-2-PHENYLPENT-1-ENYL)PHENOL × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；0.2M sodium Citrate, 20% PEG3350, VAPOR DIFFUSION, HANGING DROP
Resolution 2.30 Å R-free 0.247
2EWP Crystal structure of Estrogen Related Receptor-3 (ERR-gamma) ligand binding domaind with tamoxifen analog GSK5182 Deposited 2005-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain E 233–458（226 aa）
Not recorded TXF (Z)-4-(1-{4-[2-(DIMETHYLAMINO)ETHOXY]PHENYL}-5-HYDROXY-2-PHENYLPENT-1-ENYL)PHENOL × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；0.2M sodium Citrate, 20% PEG3350, VAPOR DIFFUSION, HANGING DROP
Resolution 2.30 Å R-free 0.247
2GP7 Estrogen Related Receptor-gamma ligand binding domain Deposited 2006-04-17 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 229–458（230 aa） Fragment：Residues 229-458
Chain B 229–458（230 aa） Fragment：Residues 229-458
Not recorded CA CALCIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；295 K；0.1m Tris pH8.0 15mM CaCl2 30% PEG600 2% PEG35K, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 295K
Resolution 2.45 Å R-free 0.263
2GP7 Estrogen Related Receptor-gamma ligand binding domain Deposited 2006-04-17 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain C 229–458（230 aa） Fragment：Residues 229-458
Chain D 229–458（230 aa） Fragment：Residues 229-458
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；295 K；0.1m Tris pH8.0 15mM CaCl2 30% PEG600 2% PEG35K, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 295K
Resolution 2.45 Å R-free 0.263
2GPO Estrogen Related Receptor-gamma ligand binding domain complexed with a synthetic peptide from RIP140 Deposited 2006-04-18 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 229–458（230 aa） Fragment：Ligand Binding Domain (Residues 229-458)
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.2；295 K；14% PEG 3350 0.2M sodium formate, pH 7.2, VAPOR DIFFUSION, HANGING DROP, temperature 295K
Resolution 1.95 Å R-free 0.231
2GPP Estrogen Related Receptor-gamma ligand binding domain complexed with a RIP140 peptide and synthetic ligand GSK4716 Deposited 2006-04-18 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 229–458（230 aa） Fragment：Residues (229-458)
Chain B 229–458（230 aa） Fragment：Residues (229-458)
Not recorded 1BA 4-HYDROXY-N'-(4-ISOPROPYLBENZYL)BENZOHYDRAZIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；295 K；9% PEG 20K 0.1M MES buffer, pH 7.5, vapor diffusion, hanging drop, temperature 295K
Resolution 2.60 Å R-free 0.257
2GPU Estrogen Related Receptor-gamma ligand binding domain complexed with 4-hydroxy-tamoxifen Deposited 2006-04-18 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 229–458（230 aa） Fragment：Ligand Binding Domain (Residues 229-458)
Not recorded OHT 4-HYDROXYTAMOXIFEN × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8；283 K；36% Peg600, 0.1M tris, 0.1% zwittergent 3-16, pH 8.0, VAPOR DIFFUSION, HANGING DROP, temperature 283K
Resolution 1.70 Å R-free 0.195
2GPV Estrogen Related Receptor-gamma ligand binding domain complexed with 4-hydroxy-tamoxifen and a SMRT peptide Deposited 2006-04-18 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric
Chain A 229–458（230 aa） Fragment：Ligand Binding Domain (residues 229-458)
Chain B 229–458（230 aa） Fragment：Ligand Binding Domain (residues 229-458)
Chain D 229–458（230 aa） Fragment：Ligand Binding Domain (residues 229-458)
Chain E 229–458（230 aa） Fragment：Ligand Binding Domain (residues 229-458)
Not recorded OHT 4-HYDROXYTAMOXIFEN × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.8；293 K；7% PEG3350 0.2M Lithium Acetate, pH 7.8, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 2.85 Å R-free 0.279
2GPV Estrogen Related Receptor-gamma ligand binding domain complexed with 4-hydroxy-tamoxifen and a SMRT peptide Deposited 2006-04-18 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric
Chain C 229–458（230 aa） Fragment：Ligand Binding Domain (residues 229-458)
Chain F 229–458（230 aa） Fragment：Ligand Binding Domain (residues 229-458)
Not recorded OHT 4-HYDROXYTAMOXIFEN × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.8；293 K；7% PEG3350 0.2M Lithium Acetate, pH 7.8, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 2.85 Å R-free 0.279
2P7G X-ray Structure of Estrogen Related Receptor g in complex with Bisphenol A. Deposited 2007-03-20 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 229–458（230 aa）
Not recorded NA SODIUM ION × 1 2OH 4,4'-PROPANE-2,2-DIYLDIPHENOL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.5；277 K；22.6% polyethylene glycol 4000, 0.1M Tris, pH 8.5 and 0.2M Sodium Acetate, VAPOR DIFFUSION, HANGING DROP, temperature 277K
Resolution 2.10 Å R-free 0.260
2P7Z Estrogen Related Receptor Gamma in complex with 4-hydroxy-tamoxifen Deposited 2007-03-21 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 229–458（230 aa）
Not recorded OHT 4-HYDROXYTAMOXIFEN × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.5；277 K；22.6% polyethylene glycol 4000, 0.1M Tris pH 8.5 and 0.2M sodium acetate, VAPOR DIFFUSION, HANGING DROP, temperature 277K
Resolution 2.50 Å R-free 0.263
2ZAS Crystal structure of human estrogen-related receptor gamma ligand binding domain complex with 4-alpha-cumylphenol, a bisphenol A derivative Deposited 2007-10-09 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 222–458（237 aa） Fragment：ligand binding domain, UNP residues 222-459
Not recorded 1OH 4-(1-methyl-1-phenylethyl)phenol × 2 GOL GLYCEROL × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；293 K；0.05M HEPES, 0.75M sodium citrate, 5% glycerol, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 293.0K
Resolution 2.00 Å R-free 0.237
2ZBS Crystal structure of human estrogen-related receptor gamma ligand binding domain apo form Deposited 2007-10-27 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 222–458（237 aa） Fragment：ligand binding domain, residues 222-459
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293.4 K；VAPOR DIFFUSION, HANGING DROP, temperature 293.4K
Resolution 1.80 Å R-free 0.244
2ZKC Crystal structure of human estrogen-related receptor gamma ligand binding domain complex with bisphenol Z Deposited 2008-03-14 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 222–458（237 aa） Fragment：ligand binding domain, UNP residues 222-459
Not recorded BPZ 4,4'-cyclohexane-1,1-diyldiphenol × 2 GOL GLYCEROL × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；293 K；0.05M HEPES, 0.75M sodium citrate, 5% glycerol, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 1.70 Å R-free 0.234
5YSO Crystal structure of Estrogen Related Receptor-3 (ERR-gamma) ligand binding domain with DN200434 Deposited 2017-11-14 Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 222–458（237 aa）
Not recorded 90C 4-[5-oxidanyl-2-phenyl-1-[4-(4-propan-2-ylpiperazin-1-yl)phenyl]pent-1-enyl]phenol × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；291 K；0.2M Ammonium fluoride, 20%(w/v) PEG 3350, 10mM Barium chloride dihydrate
Resolution 2.50 Å R-free 0.243
5YSO Crystal structure of Estrogen Related Receptor-3 (ERR-gamma) ligand binding domain with DN200434 Deposited 2017-11-14 Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 222–458（237 aa）
Not recorded 90C 4-[5-oxidanyl-2-phenyl-1-[4-(4-propan-2-ylpiperazin-1-yl)phenyl]pent-1-enyl]phenol × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；291 K；0.2M Ammonium fluoride, 20%(w/v) PEG 3350, 10mM Barium chloride dihydrate
Resolution 2.50 Å R-free 0.243
5YSO Crystal structure of Estrogen Related Receptor-3 (ERR-gamma) ligand binding domain with DN200434 Deposited 2017-11-14 Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain C 222–458（237 aa）
Not recorded 90C 4-[5-oxidanyl-2-phenyl-1-[4-(4-propan-2-ylpiperazin-1-yl)phenyl]pent-1-enyl]phenol × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；291 K；0.2M Ammonium fluoride, 20%(w/v) PEG 3350, 10mM Barium chloride dihydrate
Resolution 2.50 Å R-free 0.243
6A6K Crystal structure of Estrogen-related Receptor-3 (ERR-gamma) ligand binding domain with DN201000 Deposited 2018-06-28 Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 222–458（237 aa） Fragment：UNP residues 222-458
Not recorded 9S6 3-[(~{E})-5-oxidanyl-2-phenyl-1-[4-(4-propan-2-ylpiperazin-1-yl)phenyl]pent-1-enyl]phenol × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；291 K；0.1M BIS-TRIS pH6.5, 16 %(w/v) PEG 10K, 3% MetOH
Resolution 2.90 Å R-free 0.263
6A6K Crystal structure of Estrogen-related Receptor-3 (ERR-gamma) ligand binding domain with DN201000 Deposited 2018-06-28 Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 222–458（237 aa） Fragment：UNP residues 222-458
Not recorded 9S6 3-[(~{E})-5-oxidanyl-2-phenyl-1-[4-(4-propan-2-ylpiperazin-1-yl)phenyl]pent-1-enyl]phenol × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；291 K；0.1M BIS-TRIS pH6.5, 16 %(w/v) PEG 10K, 3% MetOH
Resolution 2.90 Å R-free 0.263
6A6K Crystal structure of Estrogen-related Receptor-3 (ERR-gamma) ligand binding domain with DN201000 Deposited 2018-06-28 Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain C 222–458（237 aa） Fragment：UNP residues 222-458
Not recorded 9S6 3-[(~{E})-5-oxidanyl-2-phenyl-1-[4-(4-propan-2-ylpiperazin-1-yl)phenyl]pent-1-enyl]phenol × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；291 K；0.1M BIS-TRIS pH6.5, 16 %(w/v) PEG 10K, 3% MetOH
Resolution 2.90 Å R-free 0.263
6I61 Crystal structure of human ERRg LBD in complex with bisphenol-B Deposited 2018-11-15 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 222–458（237 aa）
Not recorded H3W bisphenol-B × 2 EDO 1,2-ETHANEDIOL × 2 GOL GLYCEROL × 10 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 8.5；293 K；0-100 mM Sodium Acetate 100 mM Tris 23-26% PEG 8000
Resolution 1.65 Å R-free 0.219
6I62 Crystal structure of human ERRg LBD in complex with HPTE Deposited 2018-11-15 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 222–458（237 aa）
Not recorded 27N 4,4'-(2,2,2-trichloroethane-1,1-diyl)diphenol × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.5；293 K；0-100 mM Sodium Acetate 100 mM Tris 23-26% PEG 8000
Resolution 1.65 Å R-free 0.200
6I63 Crystal structure of human ERRg LBD in complex with bisphenol-A Deposited 2018-11-15 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 222–458（237 aa）
Not recorded 2OH 4,4'-PROPANE-2,2-DIYLDIPHENOL × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 8.5；293 K；0-100 mM Sodium Acetate 100 mM Tris 23-26% PEG8000
Resolution 2.23 Å R-free 0.206
6I64 Crystal structure of human ERRg LBD in complex with bisphenol-E Deposited 2018-11-15 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 222–458（237 aa）
Not recorded H48 4-[1-(4-hydroxyphenyl)ethyl]phenol × 2 GOL GLYCEROL × 6 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 8.5；293 K；0-100 mM Sodium Acetate 100 mM Tris 23-26% PEG8000
Resolution 1.91 Å R-free 0.237
6I65 Crystal structure of human ERRg LBD in complex with 4-iso-propylphenol Deposited 2018-11-15 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 222–458（237 aa）
Not recorded H3Z 4-propan-2-ylphenol × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 8.5；293 K；0-100 mM Sodium acetat 100 mM Tris 23-26% PEG8000
Resolution 1.50 Å R-free 0.198
6I66 Crystal structure of human ERRg LBD in complex with 4-sec-butylphenol Deposited 2018-11-15 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 222–458（237 aa）
Not recorded H4Q 4-[(2~{R})-butan-2-yl]phenol × 2 GOL GLYCEROL × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 8.5；293 K；0-100 mM Sodium acetate 100 mM Tris 23-26% PEG8000
Resolution 1.60 Å R-free 0.207
6I67 Crystal structure of human ERRg LBD in complex with tetrahydro-2-naphtol Deposited 2018-11-15 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 222–458（237 aa）
Not recorded H42 5,6,7,8-tetrahydronaphthalen-2-ol × 2 GOL GLYCEROL × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 8.5；293 K；0-100 mM Sodium acetate 100 mM Tris 23-26% PEG8000
Resolution 1.75 Å R-free 0.208
6K3N Crystal structure of human estrogen-related receptor gamma ligand binding domain complex with BPA-monoF Deposited 2019-05-21 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 232–458（227 aa）
Not recorded CW6 2-fluoranyl-4-[2-(4-hydroxyphenyl)propan-2-yl]phenol × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；0.05M HEPES, 0.75M sodium citrate, 5% glycerol, pH 7.5,
Resolution 1.97 Å R-free 0.253
6KNR Crystal structure of Estrogen-related receptor gamma ligand-binding domain with DN200699 Deposited 2019-08-07 Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 222–458（237 aa） Fragment：ligand-binding domain
Not recorded DL9 (E)-4-(1-(4-(1-cyclopropylpiperidin-4-yl)phenyl)-5-hydroxy-2-phenylpent-1-en-1-yl)phenol × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；291 K；0.28M K Na Tartrate
Resolution 2.80 Å R-free 0.226
6KNR Crystal structure of Estrogen-related receptor gamma ligand-binding domain with DN200699 Deposited 2019-08-07 Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 222–458（237 aa） Fragment：ligand-binding domain
Not recorded DL9 (E)-4-(1-(4-(1-cyclopropylpiperidin-4-yl)phenyl)-5-hydroxy-2-phenylpent-1-en-1-yl)phenol × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；291 K；0.28M K Na Tartrate
Resolution 2.80 Å R-free 0.226
8B4Q Ternary structure of 14-3-3s, ERRg phosphopeptide and dual-reactive compound 5 Deposited 2022-09-20 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 174–182（9 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) MG MAGNESIUM ION × 6 CL CHLORIDE ION × 2 OYI 3-fluoranyl-4-methanoyl-~{N}-methyl-~{N}-(2-sulfanylethyl)benzamide × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；277 K；0.095 M Hepes pH 7.1, 0.19 M CaCl2, 25% PEG400, 5% glycerol
Resolution 1.40 Å R-free 0.175
8BJG Ternary structure of 14-3-3s, ERRg phosphopeptide and dual-reactive compound 8 Deposited 2022-11-04 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 174–182（9 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) MG MAGNESIUM ION × 8 CL CHLORIDE ION × 2 QL0 3-methanoyl-~{N}-methyl-~{N}-(2-sulfanylethyl)benzamide × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；277 K；0.095 M Hepes pH 7.1, 0.19 M CaCl2, 25% PEG400, 5% glycerol
Resolution 1.40 Å R-free 0.175
8BJN Ternary structure of 14-3-3s, ERRg phosphopeptide and dual-reactive compound 6 Deposited 2022-11-04 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 174–182（9 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) MG MAGNESIUM ION × 6 CL CHLORIDE ION × 2 QL9 3-bromanyl-4-methanoyl-~{N}-methyl-~{N}-(2-sulfanylethyl)benzamide × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；277 K；0.095 M Hepes pH 7.1, 0.19 M CaCl2, 25% PEG400, 5% glycerol
Resolution 1.40 Å R-free 0.175
8BM5 Ternary structure of 14-3-3s, ERRg phosphopeptide and dual-reactive compound 7 Deposited 2022-11-10 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 174–182（9 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) MG MAGNESIUM ION × 6 CL CHLORIDE ION × 2 QQ0 4-methanoyl-~{N}-methyl-~{N}-(2-sulfanylethyl)benzenesulfonamide × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；277 K；0.095 M Hepes pH 7.1, 0.19 M CaCl2, 25% PEG400, 5% glycerol
Resolution 1.40 Å R-free 0.186
8IFO Crystal structure of estrogen related receptor-gamma DNA binding domain complexed with Pla2g12b promoter Deposited 2023-02-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein–DNA Homooligomer；Protein × 2 PDB declaration: tetrameric
Chain A 123–219（97 aa）
Chain B 123–219（97 aa）
Not recorded ZN ZINC ION × 5 MLI MALONATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；293 K；0.1 M Sodium malonate pH 6.0, 12% w/v Polyethylene glycol 3,350
Resolution 2.20 Å R-free 0.260
8IFO Crystal structure of estrogen related receptor-gamma DNA binding domain complexed with Pla2g12b promoter Deposited 2023-02-19 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein–DNA Monomer；Protein × 1 PDB declaration: trimeric
Chain F 123–219（97 aa）
Not recorded ZN ZINC ION × 2 MLI MALONATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；293 K；0.1 M Sodium malonate pH 6.0, 12% w/v Polyethylene glycol 3,350
Resolution 2.20 Å R-free 0.260
9KNC Crystal structure of human ERRg LBD in complex with 6-nitroindole Deposited 2024-11-18 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 229–458（230 aa）
Not recorded A1EF8 6-nitro-1~{H}-indole × 2 PGR R-1,2-PROPANEDIOL × 12 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；30%(w/v) PEG 5000 MME 0.1M Tris 8.0 0.2M lithium sulfate
Resolution 1.90 Å R-free 0.232
9KND Crystal structure of human ERRg LBD in complex with indole Deposited 2024-11-18 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 229–458（230 aa）
Not recorded IND INDOLE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；30%(w/v) PEG 5000 MME 0.1M Tris 8.0 0.2M lithium sulfate
Resolution 1.52 Å R-free 0.212
9KNE Crystal structure of human ERRg LBD in complex with 5-nitroindole Deposited 2024-11-18 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 229–458（230 aa）
Not recorded 2HU 5-nitro-1H-indole × 2 PGR R-1,2-PROPANEDIOL × 8 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；30%(w/v) PEG 5000 MME 0.1M Tris 8.0 0.2M lithium sulfate
Resolution 1.80 Å R-free 0.224
9KNF Crystal structure of human ERRg LBD in complex with 4028691 Deposited 2024-11-18 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 229–458（230 aa）
Not recorded A1EGB 5-chloranyl-2~{H}-indazole × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；1.0 M K/Na tartrate, 0.1 M Tris pH 7.0, 0.2 M Li2SO4
Resolution 1.62 Å R-free 0.228
9KNG Crystal structure of human ERRg LBD in complex with 4034496 Deposited 2024-11-18 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 229–458（230 aa）
Not recorded A1EGD 6-methyl-1,3-benzothiazole-2,4-diamine × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；30%(w/v) PEG 5000 MME, 0.1M Tris 8.0, 0.2M lithium sulfate
Resolution 1.50 Å R-free 0.234

35 other PDB entries and 45 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name ERR3_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 22–251； UniProt 229–458

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

SAXS scattering curve SAXS Profile

SAXS profile for 2p7a

P(r) Distance Distribution P(r) Distribution

P(r) distribution for 2p7a
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2. Structure Basics 2. Structure Basics

Entry ID entry_id2p7a
Deposition date deposition_date2007-03-20
Structure title titleCrystal Structure of Estrogen Related Receptor g in complex with 3-methyl phenol
Keywords keywordsthree layered alpha helical sandwich, HORMONE RECEPTOR; HORMONE RECEPTOR
Experimental Method methodX-RAY DIFFRACTION
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3. SAXS Parameters (CRYSOL theoretical calculation) 3. SAXS Parameters (CRYSOL)

Radius of gyration Rg (Guinier) rg_guinier18.87 Å
Radius of gyration Rg (electron density) rg_electron17.55 Å
Forward intensity I(0) i010888600.00
Molecular weight molecular_weight25416.0 kDa
Excluded volume excluded_volume32257 ų
Envelope volume envelope_volume36824 ų
Hydration-shell volume shell_volume17661 ų
Envelope diameter envelope_diameter60.2 Å
Shell Rg shell_rg23.64 Å
Envelope Rg envelope_rg17.77 Å
Shape Rg shape_rg17.54 Å
Total Rg total_rg18.59 Å
Total atoms total_atoms1782
Residues n_residues223
Spherical-harmonic order n_harmonics20
q range q_range— – 0.5000 Å−1
Data points n_points101
Shell type shell_typedirectional
Solvent electron density solvent_density0.3340 e/ų
Shell contrast contrast_shell0.0300 e/ų
CRYSOL version crysol_version4.1.3
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4. P(r) Distance Distribution (GNOM inversion) 4. P(r) Analysis (GNOM)

Maximum dimension Dmax dmax60.0 Å
Rg (real space) rg_real18.78 Å
Rg uncertainty (real space) rg_real_error0.38 Å
I(0) (real space) i0_real1.0890e+07
I(0) uncertainty (real space) i0_real_error1.4730e+05
Rg (reciprocal space) rg_reciprocal18.80 Å
I(0) (reciprocal space) i0_reciprocal10890000.0000
Solution quality estimate total_estimate0.8918
Solution quality rating solution_quality GOOD a GOOD solution
P(r) peaks n_peaks2
Primary peak position r_peak_primary24.2 Å
Skewness Skewness skewness0.202
Kurtosis Kurtosis kurtosis-0.390
Angular range angular_range— – 0.4200 Å−1
Current regularization parameter α current_alpha0.0000
Highest regularization parameter α highest_alpha2679000.0000
Real-space data points n_real_points73
GNOM version gnom_version4.1.3
Quality Criteria quality_criteria AN1: 0.000; Oscil: 0.881; Stabil: 0.999; Sysdev: 1.000; Positv: 1.000; Valcen: 0.999; Smooth: 0.951
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5. Crystallography and Experiment 5. Crystallography & Experiment

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6. Entities and Polymers Entities & Polymers (3)

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7. Fold Classification (SCOP + CATH) 2 domains

SCOP 2.08 (1 domains)

Domain ID domain_idd2p7aa_
Class classa — All alpha proteins
Fold Fold folda.123 — Nuclear receptor ligand-binding domain
Superfamily Superfamily superfamilya.123.1 — Nuclear receptor ligand-binding domain
Family Family familya.123.1.1 — Nuclear receptor ligand-binding domain

CATH v4.4 (1 domains)

Domain ID domain_id2p7aA00
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology565 — Retinoid X Receptor
Homologous superfamily homologous superfamily10 — Retinoid X Receptor
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8. Citations (1)

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9. Files and Curves (10)