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2qc8

Crystal structure of human glutamine synthetase in complex with ADP and methionine sulfoximine phosphate

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Glutamine synthetase

Homo sapiens

UniProt P15104

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein homooligomer Homooligomer Protein 10 MANGANESE (II) ION × 30 CHLORIDE ION × 10 ADENOSINE-5'-DIPHOSPHATE × 10 L-METHIONINE-S-SULFOXIMINE PHOSPHATE × 10 water × 10 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers
2ojw 2qc8 7evt 8dnu 9nlr 9nlr 9nm5 9otm 9otn 9oto 9otp 9otq

12 assemblies

Heteromeric or nucleic-acid complex
9nr3

1 assemblies

View Construct and Data Evidence
UniProt name GLNA_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 24–384； UniProt 5–365 Author chain B； PDBConstruct 24–384； UniProt 5–365 Author chain C； PDBConstruct 24–384； UniProt 5–365 Author chain D； PDBConstruct 24–384； UniProt 5–365 Author chain E； PDBConstruct 24–384； UniProt 5–365 Author chain F； PDBConstruct 24–384； UniProt 5–365 Author chain G； PDBConstruct 24–384； UniProt 5–365 Author chain H； PDBConstruct 24–384； UniProt 5–365 Author chain I； PDBConstruct 24–384； UniProt 5–365 Author chain J； PDBConstruct 24–384； UniProt 5–365

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id2qc8
Deposition date deposition_date2007-06-19
Structure title titleCrystal structure of human glutamine synthetase in complex with ADP and methionine sulfoximine phosphate
Keywords keywordsAmino-acid biosynthesis, Ligase, Synthetase, Structural Genomics, Structural Genomics Consortium, SGC; LIGASE
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

2qc8__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

2qc8__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 109 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

2qc8__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）47.01 Å
Rg (electron density)46.24 Å
Total Rg46.62 Å
Atom count28606
Residues3559
Excluded volume501870 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 2qc8__assembly_1__model_1 decameric （10） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (6)

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6. Fold Classification (SCOP + CATH) 20 domains

CATH v4.4 (20 domains)

Domain ID domain_id2qc8A01
Class class3 — Alpha Beta
Architecture architecture10 — Roll
Topology topology20 — Ubiquitin-like (UB roll)
Homologous superfamily homologous superfamily70 — Glutamine synthetase, N-terminal domain
Domain ID domain_id2qc8A02
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology590 — Creatine Kinase; Chain A, domain 2
Homologous superfamily homologous superfamily10 — Glutamine synthetase/guanido kinase, catalytic domain
Domain ID domain_id2qc8B01
Class class3 — Alpha Beta
Architecture architecture10 — Roll
Topology topology20 — Ubiquitin-like (UB roll)
Homologous superfamily homologous superfamily70 — Glutamine synthetase, N-terminal domain
Domain ID domain_id2qc8B02
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology590 — Creatine Kinase; Chain A, domain 2
Homologous superfamily homologous superfamily10 — Glutamine synthetase/guanido kinase, catalytic domain
Domain ID domain_id2qc8C01
Class class3 — Alpha Beta
Architecture architecture10 — Roll
Topology topology20 — Ubiquitin-like (UB roll)
Homologous superfamily homologous superfamily70 — Glutamine synthetase, N-terminal domain
Domain ID domain_id2qc8C02
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology590 — Creatine Kinase; Chain A, domain 2
Homologous superfamily homologous superfamily10 — Glutamine synthetase/guanido kinase, catalytic domain
Domain ID domain_id2qc8D01
Class class3 — Alpha Beta
Architecture architecture10 — Roll
Topology topology20 — Ubiquitin-like (UB roll)
Homologous superfamily homologous superfamily70 — Glutamine synthetase, N-terminal domain
Domain ID domain_id2qc8D02
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology590 — Creatine Kinase; Chain A, domain 2
Homologous superfamily homologous superfamily10 — Glutamine synthetase/guanido kinase, catalytic domain
Domain ID domain_id2qc8E01
Class class3 — Alpha Beta
Architecture architecture10 — Roll
Topology topology20 — Ubiquitin-like (UB roll)
Homologous superfamily homologous superfamily70 — Glutamine synthetase, N-terminal domain
Domain ID domain_id2qc8E02
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology590 — Creatine Kinase; Chain A, domain 2
Homologous superfamily homologous superfamily10 — Glutamine synthetase/guanido kinase, catalytic domain
Domain ID domain_id2qc8F01
Class class3 — Alpha Beta
Architecture architecture10 — Roll
Topology topology20 — Ubiquitin-like (UB roll)
Homologous superfamily homologous superfamily70 — Glutamine synthetase, N-terminal domain
Domain ID domain_id2qc8F02
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology590 — Creatine Kinase; Chain A, domain 2
Homologous superfamily homologous superfamily10 — Glutamine synthetase/guanido kinase, catalytic domain
Domain ID domain_id2qc8G01
Class class3 — Alpha Beta
Architecture architecture10 — Roll
Topology topology20 — Ubiquitin-like (UB roll)
Homologous superfamily homologous superfamily70 — Glutamine synthetase, N-terminal domain
Domain ID domain_id2qc8G02
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology590 — Creatine Kinase; Chain A, domain 2
Homologous superfamily homologous superfamily10 — Glutamine synthetase/guanido kinase, catalytic domain
Domain ID domain_id2qc8H01
Class class3 — Alpha Beta
Architecture architecture10 — Roll
Topology topology20 — Ubiquitin-like (UB roll)
Homologous superfamily homologous superfamily70 — Glutamine synthetase, N-terminal domain
Domain ID domain_id2qc8H02
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology590 — Creatine Kinase; Chain A, domain 2
Homologous superfamily homologous superfamily10 — Glutamine synthetase/guanido kinase, catalytic domain
Domain ID domain_id2qc8I01
Class class3 — Alpha Beta
Architecture architecture10 — Roll
Topology topology20 — Ubiquitin-like (UB roll)
Homologous superfamily homologous superfamily70 — Glutamine synthetase, N-terminal domain
Domain ID domain_id2qc8I02
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology590 — Creatine Kinase; Chain A, domain 2
Homologous superfamily homologous superfamily10 — Glutamine synthetase/guanido kinase, catalytic domain
Domain ID domain_id2qc8J01
Class class3 — Alpha Beta
Architecture architecture10 — Roll
Topology topology20 — Ubiquitin-like (UB roll)
Homologous superfamily homologous superfamily70 — Glutamine synthetase, N-terminal domain
Domain ID domain_id2qc8J02
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology590 — Creatine Kinase; Chain A, domain 2
Homologous superfamily homologous superfamily10 — Glutamine synthetase/guanido kinase, catalytic domain
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7. Citations (1)