TRANSFORMING GROWTH FACTOR ,BETA 2
Homo sapiens
State in the Current Structure
| Assembly | Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Associated Components | Method and Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|
| 1 | Protein homooligomer Homooligomer Protein × 2 PDB declaration: dimeric（2） Consistent with protein copy count | Chain A； UniProt 303–414 | Not recorded | No other associated polymer | X-RAY DIFFRACTION mmCIF provides none of the parsed experimental conditions | Resolution 1.80 Å |
Other States of the Same Protein in the Database
Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.
| Other PDB | Difference from Current Entry 2TGI | Assembly / Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Non-polymers | Method and Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|---|
| 1TFG AN UNUSUAL FEATURE REVEALED BY THE CRYSTAL STRUCTURE AT 2.2 ANGSTROMS RESOLUTION OF HUMAN TRANSFORMING GROWTH FACTOR-BETA2 Deposited 1992-11-17 | Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
303–414（112 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 1.95 Å |
| 4KXZ crystal structure of tgfb2 in complex with GC2008. Deposited 2013-05-28 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric |
Chain A
303–414（112 aa）
Fragment：unp residues 303-414
Chain B
303–414（112 aa）
Fragment：unp residues 303-414
|
Not recorded | MES 2-(N-MORPHOLINO)-ETHANESULFONIC ACID × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；pH 6；296 K；35% PEG400, 100mM MES, VAPOR DIFFUSION, temperature 296K, pH 6.0
|
Resolution 2.83 Å R-free 0.222 |
| 4KXZ crystal structure of tgfb2 in complex with GC2008. Deposited 2013-05-28 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric |
Chain D
303–414（112 aa）
Fragment：unp residues 303-414
Chain E
303–414（112 aa）
Fragment：unp residues 303-414
|
Not recorded | MES 2-(N-MORPHOLINO)-ETHANESULFONIC ACID × 3 PE5 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；pH 6；296 K；35% PEG400, 100mM MES, VAPOR DIFFUSION, temperature 296K, pH 6.0
|
Resolution 2.83 Å R-free 0.222 |
| 5TX4 Derivative of mouse TGF-beta2, with a deletion of residues 52-71 and K25R, R26K, L51R, A74K, C77S, L89V, I92V, K94R T95K, I98V single amino acid substitutions, bound to human TGF-beta type II receptor ectodomain residues 15-130 Deposited 2016-11-15 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
303–414（112 aa）
Fragment：UNP residues 303-414
|
Mutation：deletion of residues 52-71 and K25R, R26K, L51R, A74K, C77S, L89V, I92V, K94R T95K, I98V | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；0.1 M Hepes, pH 7.5, 60 % v/v (+/-)-2-Methyl-2,4-pentanediol
|
Resolution 1.88 Å R-free 0.222 |
| 6I9J Human transforming growth factor beta2 in a tetragonal crystal form Deposited 2018-11-23 | Different construct Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
331–442（112 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 4.6；293 K；20% isopropanol, 0.2M calcium chloride, 0.1M sodium acetate pH 4.6
|
Resolution 2.00 Å R-free 0.253 |
| 6XM2 The structure of the 4A11.v7 antibody in complex with human TGFb2 Deposited 2020-06-29 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric |
Chain K
303–414（112 aa）
Fragment：mature domain
Chain L
303–414（112 aa）
Fragment：mature domain
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；292 K；20% PEG 1000, 0.1 M Tris pH8.5
|
Resolution 1.91 Å R-free 0.244 |
| 6XM2 The structure of the 4A11.v7 antibody in complex with human TGFb2 Deposited 2020-06-29 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric |
Chain I
303–414（112 aa）
Fragment：mature domain
Chain J
303–414（112 aa）
Fragment：mature domain
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；292 K；20% PEG 1000, 0.1 M Tris pH8.5
|
Resolution 1.91 Å R-free 0.244 |
| 7RCO Crystal structure of human TGF-beta-2 bound to 4A11.V2 Fab Deposited 2021-07-07 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric |
Chain A
303–414（112 aa）
Fragment：mature domain (UNP residues 303-414)
Chain B
303–414（112 aa）
Fragment：mature domain (UNP residues 303-414)
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；298 K；15% PEG4000, 0.1 M sodium cacodylate, pH 6.0
|
Resolution 2.90 Å R-free 0.286 |
| 8DC0 Rat Betaglycan Zona Pellucida Domain (ZPC) in complex with mini monomer TGFb2 (mmTGF-b2-7M2R) Deposited 2022-06-15 | Different construct Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain B
303–414（112 aa）
Fragment：mmTGF-b2-7m2r (UNP residues 303-414)
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5.6；298 K；13% PEG4000, 0.1 M trisodium citrate, 10% ethylene glycol
|
Resolution 1.93 Å R-free 0.257 |
| 8FXS Crystal structure of human pro-TGF-beta2 in complex with Nb9 Deposited 2023-01-25 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
21–414（394 aa）
Chain B
21–414（394 aa）
|
Mutation：C24S, N140R, R298_R303delinsG Mutation：C24S, N140R, R298_R303delinsG | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293.15 K；Crystals of the Nb9/proTGF-beta2 complex (1 microliter) were formed in hanging drops with 1 microliter of 100 mM HEPES pH 7.6, 10% PEG 4000.
|
Resolution 3.15 Å R-free 0.301 |
| 8FXV Crystal structure of human proTGF-beta2 in complex with Nb18 Deposited 2023-01-25 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
21–414（394 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293.15 K；Crystals of the Nb18/proTGF-beta2 complex (1 microliter) were formed in hanging drops with 1 microliter of 100 mM HEPES pH 7.4, 26.7% Jeffamine ED2001.
|
Resolution 2.20 Å R-free 0.249 |
9 other PDB entries and 11 assemblies. Open the comparison page and filter oligomeric states
View Construct and Data Evidence
| UniProt name | TGF2_HUMAN |
| Isoform | — |
| PDB entities | 1 |
| Chains and sequence ranges | Author chain A； PDBConstruct 1–112； UniProt 303–414 |
