2v4d

Re-refinement of MexA adaptor protein

Method: X-RAY DIFFRACTION

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1. 蛋白身份与相关结构 Protein Identity & Related Structures

MULTIDRUG RESISTANCE PROTEIN MEXA

PSEUDOMONAS AERUGINOSA

当前结构中的状态

Assembly	物理组成	蛋白状态	分子拷贝数	共同组分	数据核对
1	蛋白同源多聚体	同源多聚体	蛋白 13	SULFATE ION × 16	与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据

UniProt名称	MEXA_PSEAE
Isoform	—
PDB实体	1
链与序列区间	作者链 A； PDB构建体 1–360； UniProt 24–383 作者链 B； PDB构建体 1–360； UniProt 24–383 作者链 C； PDB构建体 1–360； UniProt 24–383 作者链 D； PDB构建体 1–360； UniProt 24–383 作者链 E； PDB构建体 1–360； UniProt 24–383 作者链 F； PDB构建体 1–360； UniProt 24–383 作者链 G； PDB构建体 1–360； UniProt 24–383 作者链 H； PDB构建体 1–360； UniProt 24–383 作者链 I； PDB构建体 1–360； UniProt 24–383 作者链 J； PDB构建体 1–360； UniProt 24–383 作者链 K； PDB构建体 1–360； UniProt 24–383 作者链 L； PDB构建体 1–360； UniProt 24–383 作者链 M； PDB构建体 1–360； UniProt 24–383

页面优先展示蛋白身份、当前 assembly、共同组分、聚集状态和跨 PDB 结构链接。链映射与序列区间收在“数据证据”中；数据库内部编号、导入时间和 assembly 操作表达式仅用于维护，因此不在读者页面展示。

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2. 结构基本信息 2. Structure Basics

条目编号 entry_id	2v4d
沉积日期 deposition_date	2008-09-18
结构标题 title	Re-refinement of MexA adaptor protein
关键词 keywords	;MEMBRANE PROTEIN, TRANSPORT PROTEIN, CELL INNER MEMBRANE, MEXA, MEMBRANE, PALMITATE, TRANSPORT, LIPOPROTEIN, ANTIBIOTIC RESISTANCE, ANTIBIOTIC EFFLUX PUMP, COILED COIL, CELL MEMBRANE, INNER MEMBRANE, PERIPLASMIC ADAPTOR PROTEIN ;; MEMBRANE PROTEIN
实验方法 method	X-RAY DIFFRACTION

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3. Official assembly/model 理论 SAXS Official SAXS Profiles

页面只读取最新 assembly 计算结果。每一条曲线都对应明确的 PDB、official biological assembly 和 coordinate model。

2v4d__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

下载该曲线 .dat

2v4d__assembly_1__model_1 | I(q)

100 个绘图点；横轴和纵轴均采用对数尺度。

2v4d__assembly_1__model_1 | P(r) · Pending

P(r) 将按相同 assembly/model 分别计算和展示。

Rg（Guinier）	78.74 Å
Rg（电子密度）	78.43 Å
总 Rg	77.39 Å
原子数	28603
残基数	4059
排除体积	497500 Å³
最大 q	0.500 Å⁻¹

Assembly	Model	结构单元	聚集说明	状态	CRYSOL	操作
1	1	`2v4d__assembly_1__model_1`	tridecameric （13）	成功	4.1.3-1-20251215 (887e7ef)	查看下载

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4. 晶体学与实验 4. Crystallography & Experiment

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5. 实体与聚合物信息 Entities & Polymers (2)

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6. 折叠分类 (SCOP + CATH) 50 domains

CATH v4.4 (50 domains)

结构域编号 domain_id	2v4dA01
类 Class class	2 — Mainly Beta
架构 Architecture architecture	40 — Beta Barrel
拓扑 Topology topology	30 — Elongation Factor Tu (Ef-tu); domain 3
同源超家族 H-superfamily homologous superfamily	170 — Efflux pump adaptor protein, beta barrel domain

结构域编号 domain_id	2v4dA02
类 Class class	2 — Mainly Beta
架构 Architecture architecture	40 — Beta Barrel
拓扑 Topology topology	50 — OB fold (Dihydrolipoamide Acetyltransferase, E2P)
同源超家族 H-superfamily homologous superfamily	100 — RNA polymerase II/Efflux pump adaptor protein, barrel-sandwich hybrid domain

结构域编号 domain_id	2v4dA03
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	10 — Orthogonal Bundle
拓扑 Topology topology	287 — Helix Hairpins
同源超家族 H-superfamily homologous superfamily	470 — Helix hairpin bin

结构域编号 domain_id	2v4dB01
类 Class class	2 — Mainly Beta
架构 Architecture architecture	40 — Beta Barrel
拓扑 Topology topology	420 — conserved putative lor/sdh protein from methanococcus maripaludis s2 fold
同源超家族 H-superfamily homologous superfamily	20 —

结构域编号 domain_id	2v4dB02
类 Class class	2 — Mainly Beta
架构 Architecture architecture	40 — Beta Barrel
拓扑 Topology topology	30 — Elongation Factor Tu (Ef-tu); domain 3
同源超家族 H-superfamily homologous superfamily	170 — Efflux pump adaptor protein, beta barrel domain

结构域编号 domain_id	2v4dB03
类 Class class	2 — Mainly Beta
架构 Architecture architecture	40 — Beta Barrel
拓扑 Topology topology	50 — OB fold (Dihydrolipoamide Acetyltransferase, E2P)
同源超家族 H-superfamily homologous superfamily	100 — RNA polymerase II/Efflux pump adaptor protein, barrel-sandwich hybrid domain

结构域编号 domain_id	2v4dB04
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	10 — Orthogonal Bundle
拓扑 Topology topology	287 — Helix Hairpins
同源超家族 H-superfamily homologous superfamily	470 — Helix hairpin bin

结构域编号 domain_id	2v4dC01
类 Class class	2 — Mainly Beta
架构 Architecture architecture	40 — Beta Barrel
拓扑 Topology topology	420 — conserved putative lor/sdh protein from methanococcus maripaludis s2 fold
同源超家族 H-superfamily homologous superfamily	20 —

结构域编号 domain_id	2v4dC02
类 Class class	2 — Mainly Beta
架构 Architecture architecture	40 — Beta Barrel
拓扑 Topology topology	30 — Elongation Factor Tu (Ef-tu); domain 3
同源超家族 H-superfamily homologous superfamily	170 — Efflux pump adaptor protein, beta barrel domain

结构域编号 domain_id	2v4dC03
类 Class class	2 — Mainly Beta
架构 Architecture architecture	40 — Beta Barrel
拓扑 Topology topology	50 — OB fold (Dihydrolipoamide Acetyltransferase, E2P)
同源超家族 H-superfamily homologous superfamily	100 — RNA polymerase II/Efflux pump adaptor protein, barrel-sandwich hybrid domain

结构域编号 domain_id	2v4dC04
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	10 — Orthogonal Bundle
拓扑 Topology topology	287 — Helix Hairpins
同源超家族 H-superfamily homologous superfamily	470 — Helix hairpin bin

结构域编号 domain_id	2v4dD01
类 Class class	2 — Mainly Beta
架构 Architecture architecture	40 — Beta Barrel
拓扑 Topology topology	30 — Elongation Factor Tu (Ef-tu); domain 3
同源超家族 H-superfamily homologous superfamily	170 — Efflux pump adaptor protein, beta barrel domain

结构域编号 domain_id	2v4dD02
类 Class class	2 — Mainly Beta
架构 Architecture architecture	40 — Beta Barrel
拓扑 Topology topology	50 — OB fold (Dihydrolipoamide Acetyltransferase, E2P)
同源超家族 H-superfamily homologous superfamily	100 — RNA polymerase II/Efflux pump adaptor protein, barrel-sandwich hybrid domain

结构域编号 domain_id	2v4dD03
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	10 — Orthogonal Bundle
拓扑 Topology topology	287 — Helix Hairpins
同源超家族 H-superfamily homologous superfamily	470 — Helix hairpin bin

结构域编号 domain_id	2v4dE01
类 Class class	2 — Mainly Beta
架构 Architecture architecture	40 — Beta Barrel
拓扑 Topology topology	420 — conserved putative lor/sdh protein from methanococcus maripaludis s2 fold
同源超家族 H-superfamily homologous superfamily	20 —

结构域编号 domain_id	2v4dE02
类 Class class	2 — Mainly Beta
架构 Architecture architecture	40 — Beta Barrel
拓扑 Topology topology	30 — Elongation Factor Tu (Ef-tu); domain 3
同源超家族 H-superfamily homologous superfamily	170 — Efflux pump adaptor protein, beta barrel domain

结构域编号 domain_id	2v4dE03
类 Class class	2 — Mainly Beta
架构 Architecture architecture	40 — Beta Barrel
拓扑 Topology topology	50 — OB fold (Dihydrolipoamide Acetyltransferase, E2P)
同源超家族 H-superfamily homologous superfamily	100 — RNA polymerase II/Efflux pump adaptor protein, barrel-sandwich hybrid domain

结构域编号 domain_id	2v4dE04
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	10 — Orthogonal Bundle
拓扑 Topology topology	287 — Helix Hairpins
同源超家族 H-superfamily homologous superfamily	470 — Helix hairpin bin

结构域编号 domain_id	2v4dF01
类 Class class	2 — Mainly Beta
架构 Architecture architecture	40 — Beta Barrel
拓扑 Topology topology	420 — conserved putative lor/sdh protein from methanococcus maripaludis s2 fold
同源超家族 H-superfamily homologous superfamily	20 —

结构域编号 domain_id	2v4dF02
类 Class class	2 — Mainly Beta
架构 Architecture architecture	40 — Beta Barrel
拓扑 Topology topology	30 — Elongation Factor Tu (Ef-tu); domain 3
同源超家族 H-superfamily homologous superfamily	170 — Efflux pump adaptor protein, beta barrel domain

结构域编号 domain_id	2v4dF03
类 Class class	2 — Mainly Beta
架构 Architecture architecture	40 — Beta Barrel
拓扑 Topology topology	50 — OB fold (Dihydrolipoamide Acetyltransferase, E2P)
同源超家族 H-superfamily homologous superfamily	100 — RNA polymerase II/Efflux pump adaptor protein, barrel-sandwich hybrid domain

结构域编号 domain_id	2v4dF04
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	10 — Orthogonal Bundle
拓扑 Topology topology	287 — Helix Hairpins
同源超家族 H-superfamily homologous superfamily	470 — Helix hairpin bin

结构域编号 domain_id	2v4dG01
类 Class class	2 — Mainly Beta
架构 Architecture architecture	40 — Beta Barrel
拓扑 Topology topology	420 — conserved putative lor/sdh protein from methanococcus maripaludis s2 fold
同源超家族 H-superfamily homologous superfamily	20 —

结构域编号 domain_id	2v4dG02
类 Class class	2 — Mainly Beta
架构 Architecture architecture	40 — Beta Barrel
拓扑 Topology topology	30 — Elongation Factor Tu (Ef-tu); domain 3
同源超家族 H-superfamily homologous superfamily	170 — Efflux pump adaptor protein, beta barrel domain

结构域编号 domain_id	2v4dG03
类 Class class	2 — Mainly Beta
架构 Architecture architecture	40 — Beta Barrel
拓扑 Topology topology	50 — OB fold (Dihydrolipoamide Acetyltransferase, E2P)
同源超家族 H-superfamily homologous superfamily	100 — RNA polymerase II/Efflux pump adaptor protein, barrel-sandwich hybrid domain

结构域编号 domain_id	2v4dG04
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	10 — Orthogonal Bundle
拓扑 Topology topology	287 — Helix Hairpins
同源超家族 H-superfamily homologous superfamily	470 — Helix hairpin bin

结构域编号 domain_id	2v4dH01
类 Class class	2 — Mainly Beta
架构 Architecture architecture	40 — Beta Barrel
拓扑 Topology topology	420 — conserved putative lor/sdh protein from methanococcus maripaludis s2 fold
同源超家族 H-superfamily homologous superfamily	20 —

结构域编号 domain_id	2v4dH02
类 Class class	2 — Mainly Beta
架构 Architecture architecture	40 — Beta Barrel
拓扑 Topology topology	30 — Elongation Factor Tu (Ef-tu); domain 3
同源超家族 H-superfamily homologous superfamily	170 — Efflux pump adaptor protein, beta barrel domain

结构域编号 domain_id	2v4dH03
类 Class class	2 — Mainly Beta
架构 Architecture architecture	40 — Beta Barrel
拓扑 Topology topology	50 — OB fold (Dihydrolipoamide Acetyltransferase, E2P)
同源超家族 H-superfamily homologous superfamily	100 — RNA polymerase II/Efflux pump adaptor protein, barrel-sandwich hybrid domain

结构域编号 domain_id	2v4dH04
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	10 — Orthogonal Bundle
拓扑 Topology topology	287 — Helix Hairpins
同源超家族 H-superfamily homologous superfamily	470 — Helix hairpin bin

结构域编号 domain_id	2v4dI01
类 Class class	2 — Mainly Beta
架构 Architecture architecture	40 — Beta Barrel
拓扑 Topology topology	420 — conserved putative lor/sdh protein from methanococcus maripaludis s2 fold
同源超家族 H-superfamily homologous superfamily	20 —

结构域编号 domain_id	2v4dI02
类 Class class	2 — Mainly Beta
架构 Architecture architecture	40 — Beta Barrel
拓扑 Topology topology	30 — Elongation Factor Tu (Ef-tu); domain 3
同源超家族 H-superfamily homologous superfamily	170 — Efflux pump adaptor protein, beta barrel domain

结构域编号 domain_id	2v4dI03
类 Class class	2 — Mainly Beta
架构 Architecture architecture	40 — Beta Barrel
拓扑 Topology topology	50 — OB fold (Dihydrolipoamide Acetyltransferase, E2P)
同源超家族 H-superfamily homologous superfamily	100 — RNA polymerase II/Efflux pump adaptor protein, barrel-sandwich hybrid domain

结构域编号 domain_id	2v4dI04
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	10 — Orthogonal Bundle
拓扑 Topology topology	287 — Helix Hairpins
同源超家族 H-superfamily homologous superfamily	470 — Helix hairpin bin

结构域编号 domain_id	2v4dJ01
类 Class class	2 — Mainly Beta
架构 Architecture architecture	40 — Beta Barrel
拓扑 Topology topology	420 — conserved putative lor/sdh protein from methanococcus maripaludis s2 fold
同源超家族 H-superfamily homologous superfamily	20 —

结构域编号 domain_id	2v4dJ02
类 Class class	2 — Mainly Beta
架构 Architecture architecture	40 — Beta Barrel
拓扑 Topology topology	30 — Elongation Factor Tu (Ef-tu); domain 3
同源超家族 H-superfamily homologous superfamily	170 — Efflux pump adaptor protein, beta barrel domain

结构域编号 domain_id	2v4dJ03
类 Class class	2 — Mainly Beta
架构 Architecture architecture	40 — Beta Barrel
拓扑 Topology topology	50 — OB fold (Dihydrolipoamide Acetyltransferase, E2P)
同源超家族 H-superfamily homologous superfamily	100 — RNA polymerase II/Efflux pump adaptor protein, barrel-sandwich hybrid domain

结构域编号 domain_id	2v4dJ04
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	10 — Orthogonal Bundle
拓扑 Topology topology	287 — Helix Hairpins
同源超家族 H-superfamily homologous superfamily	470 — Helix hairpin bin

结构域编号 domain_id	2v4dK01
类 Class class	2 — Mainly Beta
架构 Architecture architecture	40 — Beta Barrel
拓扑 Topology topology	420 — conserved putative lor/sdh protein from methanococcus maripaludis s2 fold
同源超家族 H-superfamily homologous superfamily	20 —

结构域编号 domain_id	2v4dK02
类 Class class	2 — Mainly Beta
架构 Architecture architecture	40 — Beta Barrel
拓扑 Topology topology	30 — Elongation Factor Tu (Ef-tu); domain 3
同源超家族 H-superfamily homologous superfamily	170 — Efflux pump adaptor protein, beta barrel domain

结构域编号 domain_id	2v4dK03
类 Class class	2 — Mainly Beta
架构 Architecture architecture	40 — Beta Barrel
拓扑 Topology topology	50 — OB fold (Dihydrolipoamide Acetyltransferase, E2P)
同源超家族 H-superfamily homologous superfamily	100 — RNA polymerase II/Efflux pump adaptor protein, barrel-sandwich hybrid domain

结构域编号 domain_id	2v4dK04
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	10 — Orthogonal Bundle
拓扑 Topology topology	287 — Helix Hairpins
同源超家族 H-superfamily homologous superfamily	470 — Helix hairpin bin

结构域编号 domain_id	2v4dL01
类 Class class	2 — Mainly Beta
架构 Architecture architecture	40 — Beta Barrel
拓扑 Topology topology	420 — conserved putative lor/sdh protein from methanococcus maripaludis s2 fold
同源超家族 H-superfamily homologous superfamily	20 —

结构域编号 domain_id	2v4dL02
类 Class class	2 — Mainly Beta
架构 Architecture architecture	40 — Beta Barrel
拓扑 Topology topology	30 — Elongation Factor Tu (Ef-tu); domain 3
同源超家族 H-superfamily homologous superfamily	170 — Efflux pump adaptor protein, beta barrel domain

结构域编号 domain_id	2v4dL03
类 Class class	2 — Mainly Beta
架构 Architecture architecture	40 — Beta Barrel
拓扑 Topology topology	50 — OB fold (Dihydrolipoamide Acetyltransferase, E2P)
同源超家族 H-superfamily homologous superfamily	100 — RNA polymerase II/Efflux pump adaptor protein, barrel-sandwich hybrid domain

结构域编号 domain_id	2v4dL04
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	10 — Orthogonal Bundle
拓扑 Topology topology	287 — Helix Hairpins
同源超家族 H-superfamily homologous superfamily	470 — Helix hairpin bin

结构域编号 domain_id	2v4dM01
类 Class class	2 — Mainly Beta
架构 Architecture architecture	40 — Beta Barrel
拓扑 Topology topology	420 — conserved putative lor/sdh protein from methanococcus maripaludis s2 fold
同源超家族 H-superfamily homologous superfamily	20 —

结构域编号 domain_id	2v4dM02
类 Class class	2 — Mainly Beta
架构 Architecture architecture	40 — Beta Barrel
拓扑 Topology topology	30 — Elongation Factor Tu (Ef-tu); domain 3
同源超家族 H-superfamily homologous superfamily	170 — Efflux pump adaptor protein, beta barrel domain

结构域编号 domain_id	2v4dM03
类 Class class	2 — Mainly Beta
架构 Architecture architecture	40 — Beta Barrel
拓扑 Topology topology	50 — OB fold (Dihydrolipoamide Acetyltransferase, E2P)
同源超家族 H-superfamily homologous superfamily	100 — RNA polymerase II/Efflux pump adaptor protein, barrel-sandwich hybrid domain

结构域编号 domain_id	2v4dM04
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	10 — Orthogonal Bundle
拓扑 Topology topology	287 — Helix Hairpins
同源超家族 H-superfamily homologous superfamily	470 — Helix hairpin bin

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晶胞边长 a length_a	130.551 Å
晶胞边长 b length_b	183.585 Å
晶胞边长 c length_c	213.314 Å
晶胞夹角 α angle_alpha	90.00 °
晶胞夹角 β angle_beta	107.38 °
晶胞夹角 γ angle_gamma	90.00 °
晶胞分子数 Z z_pdb	26

空间群 space_group	P 1 21 1
空间群编号 int_tables_number	4
晶系 crystal_system	—

分辨率 resolution	3.200 Å
最低分辨率 resolution_low	65.580 Å
R 因子 r_factor	0.2400
R_work r_work	0.2390
R_free r_free	0.2640

描述 description	MULTIDRUG RESISTANCE PROTEIN MEXA
分子量 formula_weight	38617.4 kDa
突变 mutation	YES
来源方法 src_method	man
拷贝数 entity_count	13

聚合物类型 type	polypeptide(L)
链编号 strand_id	A,B,C,D,E,F,G,H,I,J,K,L,M
原子数 atom_count	28603

Re-refinement of MexA adaptor protein

1. 蛋白身份与相关结构 Protein Identity & Related Structures

MULTIDRUG RESISTANCE PROTEIN MEXA

当前结构中的状态

数据库中的同蛋白其他状态

2. 结构基本信息 2. Structure Basics

3. Official assembly/model 理论 SAXS Official SAXS Profiles

2v4d__assembly_1__model_1

2v4d__assembly_1__model_1 | I(q)

2v4d__assembly_1__model_1 | P(r) · Pending

4. 晶体学与实验 4. Crystallography & Experiment

晶胞参数 Unit Cell

对称性 Symmetry

精修参数 Refinement

衍射实验 Diffraction

5. 实体与聚合物信息 Entities & Polymers (2)

实体 1 Entity 1 polymer

聚合物 Polymer

来源 Source

实体 2 Entity 2 non-polymer

6. 折叠分类 (SCOP + CATH) 50 domains

CATH v4.4 (50 domains)

7. 引用文献 (1)

来源生物 organism	PSEUDOMONAS AERUGINOSA
NCBI 分类编号 ncbi_taxonomy_id	287
宿主生物 host_organism	ESCHERICHIA COLI

描述 description	SULFATE ION
分子量 formula_weight	96.1 kDa
来源方法 src_method	syn
拷贝数 entity_count	16

Re-refinement of MexA adaptor protein

1. 蛋白身份与相关结构 Protein Identity & Related Structures

MULTIDRUG RESISTANCE PROTEIN MEXA

当前结构中的状态

数据库中的同蛋白其他状态

单体

同源二聚体

同源四聚体

其他同源多聚体

异源或核酸复合物

2. 结构基本信息 2. Structure Basics

3. Official assembly/model 理论 SAXS Official SAXS Profiles

2v4d__assembly_1__model_1

2v4d__assembly_1__model_1 | I(q)

2v4d__assembly_1__model_1 | P(r) · Pending

4. 晶体学与实验 4. Crystallography & Experiment

晶胞参数 Unit Cell

对称性 Symmetry

精修参数 Refinement

衍射实验 Diffraction

5. 实体与聚合物信息 Entities & Polymers (2)

实体 1 Entity 1 polymer

聚合物 Polymer

来源 Source

实体 2 Entity 2 non-polymer

6. 折叠分类 (SCOP + CATH) 50 domains

CATH v4.4 (50 domains)

7. 引用文献 (1)