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2v7a

Crystal structure of the T315I Abl mutant in complex with the inhibitor PHA-739358

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL1

HOMO SAPIENS

UniProt P00519

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein monomer Monomer Protein 1 N-[(3E)-5-[(2R)-2-METHOXY-2-PHENYLACETYL]PYRROLO[3,4-C]PYRAZOL-3(5H)-YLIDENE]-4-(4-METHYLPIPERAZIN-1-YL)BENZAMIDE × 1 MAGNESIUM ION × 1 water × 1 Consistent with protein count
2 Protein monomer Monomer Protein 1 N-[(3E)-5-[(2R)-2-METHOXY-2-PHENYLACETYL]PYRROLO[3,4-C]PYRAZOL-3(5H)-YLIDENE]-4-(4-METHYLPIPERAZIN-1-YL)BENZAMIDE × 1 MAGNESIUM ION × 1 water × 1 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1ab2 1awo 1opl 1opl 1zzp 2abl 2e2b 2e2b 2g2f 2g2h 2g2h 2gqg

100 assemblies; showing the first 12

Homodimer
1opl 3qri 3qrj 6npe 6npu 7w7x 7w7y

7 assemblies

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1bbz 1bbz 1bbz 1bbz 1ju5 2g1t 2g1t 2g1t 2g1t 2g2f 2g2i 2g2i

50 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name ABL1_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 3–286； UniProt 229–512 Author chain B； PDBConstruct 3–286； UniProt 229–512

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id2v7a
Deposition date deposition_date2007-07-27
Structure title titleCrystal structure of the T315I Abl mutant in complex with the inhibitor PHA-739358
Keywords keywords;KINASE, NUCLEUS, MYRISTATE, CYTOPLASM, MANGANESE, CELL ADHESION, METAL-BINDING, PROTO-ONCOGENE, TYROSINE-PROTEIN KINASE, CHROMOSOMAL REARRANGEMENT, TRANSFERASE, LIPOPROTEIN, POLYMORPHISM, CYTOSKELETON, MAGNESIUM, SH2 DOMAIN, SH3 DOMAIN, ATP-BINDING, NUCLEOTIDE-BINDING, ALTERNATIVE SPLICING, PHOSPHORYLATION, KINASE INHIBITOR, T315I ABL MUTANT ;; TRANSFERASE
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

2v7a__assembly_2__model_1

Assembly 2 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

2v7a__assembly_2__model_1 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

2v7a__assembly_2__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）20.23 Å
Rg (electron density)19.17 Å
Total Rg20.14 Å
Atom count2232
Residues269
Excluded volume39974 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 2v7a__assembly_1__model_1 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 2v7a__assembly_2__model_1 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (4)

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6. Fold Classification (SCOP + CATH) 6 domains

SCOP 2.08 (2 domains)

Domain ID domain_idd2v7aa_
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.144 — Protein kinase-like (PK-like)
Superfamily Superfamily superfamilyd.144.1 — Protein kinase-like (PK-like)
Family Family familyd.144.1.7 — Protein kinases, catalytic subunit
Domain ID domain_idd2v7ab_
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.144 — Protein kinase-like (PK-like)
Superfamily Superfamily superfamilyd.144.1 — Protein kinase-like (PK-like)
Family Family familyd.144.1.7 — Protein kinases, catalytic subunit

CATH v4.4 (4 domains)

Domain ID domain_id2v7aA01
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology200 — Phosphorylase Kinase; domain 1
Homologous superfamily homologous superfamily20 — Phosphorylase Kinase; domain 1
Domain ID domain_id2v7aA02
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology510 — Transferase(Phosphotransferase); domain 1
Homologous superfamily homologous superfamily10 — Transferase(Phosphotransferase) domain 1
Domain ID domain_id2v7aB01
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology200 — Phosphorylase Kinase; domain 1
Homologous superfamily homologous superfamily20 — Phosphorylase Kinase; domain 1
Domain ID domain_id2v7aB02
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology510 — Transferase(Phosphotransferase); domain 1
Homologous superfamily homologous superfamily10 — Transferase(Phosphotransferase) domain 1
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7. Citations (1)