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2v8x

Crystallographic and mass spectrometric characterisation of eIF4E with N7-cap derivatives

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

EUKARYOTIC TRANSLATION INITIATION FACTOR 4E

HOMO SAPIENS

UniProt P06730

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 2 EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-BINDING PROTEIN 1 × 1 （Q13541） 7-BENZYL GUANINE MONOPHOSPHATE × 1 water × 2 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 2 EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-BINDING PROTEIN 1 × 1 （Q13541） 7-BENZYL GUANINE MONOPHOSPHATE × 1 water × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1ipb 1ipc 2gpq 3tf2 3tf2 3tf2 3tf2 4dt6 4dum 4tpw 4tpw 4tqb

22 assemblies; showing the first 12

Homodimer
8qm4 8qm5 8qm6 8qm7 8qm8 8qm9

6 assemblies

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1wkw 2v8w 2v8w 2v8x 2v8x 2v8y 2v8y 2w97 3am7 3u7x 3u7x 3u7x

37 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name IF4E_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–217； UniProt 1–217 Author chain E； PDBConstruct 1–217； UniProt 1–217

EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-BINDING PROTEIN 1

OrganismNot specified

UniProt Q13541

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 2 EUKARYOTIC TRANSLATION INITIATION FACTOR 4E × 1 （P06730） 7-BENZYL GUANINE MONOPHOSPHATE × 1 water × 2 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 2 EUKARYOTIC TRANSLATION INITIATION FACTOR 4E × 1 （P06730） 7-BENZYL GUANINE MONOPHOSPHATE × 1 water × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1wkw 2jgb 2jgc 2v8w 2v8w 2v8x 2v8x 2v8y 2v8y 3hxg 3hxi 3m93

30 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name 4EBP1_HUMAN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain B； PDBConstruct 1–14； UniProt 50–63 Author chain F； PDBConstruct 1–14； UniProt 50–63

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id2v8x
Deposition date deposition_date2007-08-16
Structure title titleCrystallographic and mass spectrometric characterisation of eIF4E with N7-cap derivatives
Keywords keywords;TRANSLATION, PHOSPHORYLATION, INITIATION FACTOR, CAP, EIF4E, 7BNGMP, 4E-BP1, RNA-BINDING, ACETYLATION, HOST-VIRUS INTERACTION, PROTEIN SYNTHESIS INHIBITOR, PROTEIN BIOSYNTHESIS, TRANSLATION REGULATION ;; TRANSLATION
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

2v8x__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

2v8x__assembly_1__model_1 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

2v8x__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）17.72 Å
Rg (electron density)16.40 Å
Total Rg17.59 Å
Atom count1664
Residues195
Excluded volume29454 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 2v8x__assembly_1__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 2v8x__assembly_2__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (4)

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6. Fold Classification (SCOP + CATH) 4 domains

SCOP 2.08 (2 domains)

Domain ID domain_idd2v8xa1
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.86 — eIF4e-like
Superfamily Superfamily superfamilyd.86.1 — eIF4e-like
Family Family familyd.86.1.1 — Translation initiation factor eIF4e
Domain ID domain_idd2v8xe1
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.86 — eIF4e-like
Superfamily Superfamily superfamilyd.86.1 — eIF4e-like
Family Family familyd.86.1.1 — Translation initiation factor eIF4e

CATH v4.4 (2 domains)

Domain ID domain_id2v8xA00
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology760 — RNA Cap, Translation Initiation Factor Eif4e
Homologous superfamily homologous superfamily10 — RNA Cap, Translation Initiation Factor Eif4e
Domain ID domain_id2v8xE00
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology760 — RNA Cap, Translation Initiation Factor Eif4e
Homologous superfamily homologous superfamily10 — RNA Cap, Translation Initiation Factor Eif4e
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7. Citations (1)