3s2d

RNA Polymerase II Initiation Complex with a 5-nt RNA containing a 5Br-U

Method: X-RAY DIFFRACTION
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1. 蛋白身份与相关结构 Protein Identity & Related Structures

DNA-directed RNA polymerase II subunit RPB1

物种未注明

UniProt P04050

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 其他组合 异源复合物 蛋白 10 DNA 1 RNA 1 DNA-directed RNA polymerase II subunit RPB2 × 1 (P08518) DNA-directed RNA polymerase II subunit RPB3 × 1 (P16370) DNA-directed RNA polymerases I, II, and III subunit RPABC1 × 1 (P20434) DNA-directed RNA polymerases I, II, and III subunit RPABC2 × 1 (P20435) DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 (P20436) DNA-directed RNA polymerase II subunit RPB9 × 1 (P27999) DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 (P22139) DNA-directed RNA polymerase II subunit RPB11 × 1 (P38902) DNA-directed RNA polymerases I, II, and III subunit RPABC4 × 1 (P40422) ;RNA (5'-R(*AP*GP*GP*(5BU)P*G)-3') ; × 1 ;DNA (5'-D(*CP*TP*AP*CP*CP*GP*AP*TP*AP*AP*GP*CP*AP*GP*AP*CP*GP*AP*TP*CP*AP*CP*CP*TP*CP*GP*AP*TP*G)-3') ; × 1 ZINC ION × 8 MAGNESIUM ION × 1 与全部聚合物一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 RPB1_YEAST
Isoform —
PDB实体 1
链与序列区间 作者链 A; PDB构建体 1–1733; UniProt 1–1733

DNA-directed RNA polymerase II subunit RPB2

物种未注明

UniProt P08518

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 其他组合 异源复合物 蛋白 10 DNA 1 RNA 1 DNA-directed RNA polymerase II subunit RPB1 × 1 (P04050) DNA-directed RNA polymerase II subunit RPB3 × 1 (P16370) DNA-directed RNA polymerases I, II, and III subunit RPABC1 × 1 (P20434) DNA-directed RNA polymerases I, II, and III subunit RPABC2 × 1 (P20435) DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 (P20436) DNA-directed RNA polymerase II subunit RPB9 × 1 (P27999) DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 (P22139) DNA-directed RNA polymerase II subunit RPB11 × 1 (P38902) DNA-directed RNA polymerases I, II, and III subunit RPABC4 × 1 (P40422) ;RNA (5'-R(*AP*GP*GP*(5BU)P*G)-3') ; × 1 ;DNA (5'-D(*CP*TP*AP*CP*CP*GP*AP*TP*AP*AP*GP*CP*AP*GP*AP*CP*GP*AP*TP*CP*AP*CP*CP*TP*CP*GP*AP*TP*G)-3') ; × 1 ZINC ION × 8 MAGNESIUM ION × 1 与全部聚合物一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 RPB2_YEAST
Isoform —
PDB实体 2
链与序列区间 作者链 B; PDB构建体 1–1224; UniProt 1–1224

DNA-directed RNA polymerase II subunit RPB3

物种未注明

UniProt P16370

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 其他组合 异源复合物 蛋白 10 DNA 1 RNA 1 DNA-directed RNA polymerase II subunit RPB1 × 1 (P04050) DNA-directed RNA polymerase II subunit RPB2 × 1 (P08518) DNA-directed RNA polymerases I, II, and III subunit RPABC1 × 1 (P20434) DNA-directed RNA polymerases I, II, and III subunit RPABC2 × 1 (P20435) DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 (P20436) DNA-directed RNA polymerase II subunit RPB9 × 1 (P27999) DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 (P22139) DNA-directed RNA polymerase II subunit RPB11 × 1 (P38902) DNA-directed RNA polymerases I, II, and III subunit RPABC4 × 1 (P40422) ;RNA (5'-R(*AP*GP*GP*(5BU)P*G)-3') ; × 1 ;DNA (5'-D(*CP*TP*AP*CP*CP*GP*AP*TP*AP*AP*GP*CP*AP*GP*AP*CP*GP*AP*TP*CP*AP*CP*CP*TP*CP*GP*AP*TP*G)-3') ; × 1 ZINC ION × 8 MAGNESIUM ION × 1 与全部聚合物一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 RPB3_YEAST
Isoform —
PDB实体 3
链与序列区间 作者链 C; PDB构建体 1–318; UniProt 1–318

DNA-directed RNA polymerases I, II, and III subunit RPABC1

物种未注明

UniProt P20434

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 其他组合 异源复合物 蛋白 10 DNA 1 RNA 1 DNA-directed RNA polymerase II subunit RPB1 × 1 (P04050) DNA-directed RNA polymerase II subunit RPB2 × 1 (P08518) DNA-directed RNA polymerase II subunit RPB3 × 1 (P16370) DNA-directed RNA polymerases I, II, and III subunit RPABC2 × 1 (P20435) DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 (P20436) DNA-directed RNA polymerase II subunit RPB9 × 1 (P27999) DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 (P22139) DNA-directed RNA polymerase II subunit RPB11 × 1 (P38902) DNA-directed RNA polymerases I, II, and III subunit RPABC4 × 1 (P40422) ;RNA (5'-R(*AP*GP*GP*(5BU)P*G)-3') ; × 1 ;DNA (5'-D(*CP*TP*AP*CP*CP*GP*AP*TP*AP*AP*GP*CP*AP*GP*AP*CP*GP*AP*TP*CP*AP*CP*CP*TP*CP*GP*AP*TP*G)-3') ; × 1 ZINC ION × 8 MAGNESIUM ION × 1 与全部聚合物一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 RPAB1_YEAST
Isoform —
PDB实体 4
链与序列区间 作者链 E; PDB构建体 1–215; UniProt 1–215

DNA-directed RNA polymerases I, II, and III subunit RPABC2

物种未注明

UniProt P20435

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 其他组合 异源复合物 蛋白 10 DNA 1 RNA 1 DNA-directed RNA polymerase II subunit RPB1 × 1 (P04050) DNA-directed RNA polymerase II subunit RPB2 × 1 (P08518) DNA-directed RNA polymerase II subunit RPB3 × 1 (P16370) DNA-directed RNA polymerases I, II, and III subunit RPABC1 × 1 (P20434) DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 (P20436) DNA-directed RNA polymerase II subunit RPB9 × 1 (P27999) DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 (P22139) DNA-directed RNA polymerase II subunit RPB11 × 1 (P38902) DNA-directed RNA polymerases I, II, and III subunit RPABC4 × 1 (P40422) ;RNA (5'-R(*AP*GP*GP*(5BU)P*G)-3') ; × 1 ;DNA (5'-D(*CP*TP*AP*CP*CP*GP*AP*TP*AP*AP*GP*CP*AP*GP*AP*CP*GP*AP*TP*CP*AP*CP*CP*TP*CP*GP*AP*TP*G)-3') ; × 1 ZINC ION × 8 MAGNESIUM ION × 1 与全部聚合物一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 RPAB2_YEAST
Isoform —
PDB实体 5
链与序列区间 作者链 F; PDB构建体 1–155; UniProt 1–155

DNA-directed RNA polymerases I, II, and III subunit RPABC3

物种未注明

UniProt P20436

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 其他组合 异源复合物 蛋白 10 DNA 1 RNA 1 DNA-directed RNA polymerase II subunit RPB1 × 1 (P04050) DNA-directed RNA polymerase II subunit RPB2 × 1 (P08518) DNA-directed RNA polymerase II subunit RPB3 × 1 (P16370) DNA-directed RNA polymerases I, II, and III subunit RPABC1 × 1 (P20434) DNA-directed RNA polymerases I, II, and III subunit RPABC2 × 1 (P20435) DNA-directed RNA polymerase II subunit RPB9 × 1 (P27999) DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 (P22139) DNA-directed RNA polymerase II subunit RPB11 × 1 (P38902) DNA-directed RNA polymerases I, II, and III subunit RPABC4 × 1 (P40422) ;RNA (5'-R(*AP*GP*GP*(5BU)P*G)-3') ; × 1 ;DNA (5'-D(*CP*TP*AP*CP*CP*GP*AP*TP*AP*AP*GP*CP*AP*GP*AP*CP*GP*AP*TP*CP*AP*CP*CP*TP*CP*GP*AP*TP*G)-3') ; × 1 ZINC ION × 8 MAGNESIUM ION × 1 与全部聚合物一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 RPAB3_YEAST
Isoform —
PDB实体 6
链与序列区间 作者链 H; PDB构建体 1–146; UniProt 1–146

DNA-directed RNA polymerase II subunit RPB9

物种未注明

UniProt P27999

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 其他组合 异源复合物 蛋白 10 DNA 1 RNA 1 DNA-directed RNA polymerase II subunit RPB1 × 1 (P04050) DNA-directed RNA polymerase II subunit RPB2 × 1 (P08518) DNA-directed RNA polymerase II subunit RPB3 × 1 (P16370) DNA-directed RNA polymerases I, II, and III subunit RPABC1 × 1 (P20434) DNA-directed RNA polymerases I, II, and III subunit RPABC2 × 1 (P20435) DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 (P20436) DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 (P22139) DNA-directed RNA polymerase II subunit RPB11 × 1 (P38902) DNA-directed RNA polymerases I, II, and III subunit RPABC4 × 1 (P40422) ;RNA (5'-R(*AP*GP*GP*(5BU)P*G)-3') ; × 1 ;DNA (5'-D(*CP*TP*AP*CP*CP*GP*AP*TP*AP*AP*GP*CP*AP*GP*AP*CP*GP*AP*TP*CP*AP*CP*CP*TP*CP*GP*AP*TP*G)-3') ; × 1 ZINC ION × 8 MAGNESIUM ION × 1 与全部聚合物一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 RPB9_YEAST
Isoform —
PDB实体 7
链与序列区间 作者链 I; PDB构建体 1–122; UniProt 1–122

DNA-directed RNA polymerases I, II, and III subunit RPABC5

物种未注明

UniProt P22139

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 其他组合 异源复合物 蛋白 10 DNA 1 RNA 1 DNA-directed RNA polymerase II subunit RPB1 × 1 (P04050) DNA-directed RNA polymerase II subunit RPB2 × 1 (P08518) DNA-directed RNA polymerase II subunit RPB3 × 1 (P16370) DNA-directed RNA polymerases I, II, and III subunit RPABC1 × 1 (P20434) DNA-directed RNA polymerases I, II, and III subunit RPABC2 × 1 (P20435) DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 (P20436) DNA-directed RNA polymerase II subunit RPB9 × 1 (P27999) DNA-directed RNA polymerase II subunit RPB11 × 1 (P38902) DNA-directed RNA polymerases I, II, and III subunit RPABC4 × 1 (P40422) ;RNA (5'-R(*AP*GP*GP*(5BU)P*G)-3') ; × 1 ;DNA (5'-D(*CP*TP*AP*CP*CP*GP*AP*TP*AP*AP*GP*CP*AP*GP*AP*CP*GP*AP*TP*CP*AP*CP*CP*TP*CP*GP*AP*TP*G)-3') ; × 1 ZINC ION × 8 MAGNESIUM ION × 1 与全部聚合物一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 RPAB5_YEAST
Isoform —
PDB实体 8
链与序列区间 作者链 J; PDB构建体 1–70; UniProt 1–70

DNA-directed RNA polymerase II subunit RPB11

物种未注明

UniProt P38902

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 其他组合 异源复合物 蛋白 10 DNA 1 RNA 1 DNA-directed RNA polymerase II subunit RPB1 × 1 (P04050) DNA-directed RNA polymerase II subunit RPB2 × 1 (P08518) DNA-directed RNA polymerase II subunit RPB3 × 1 (P16370) DNA-directed RNA polymerases I, II, and III subunit RPABC1 × 1 (P20434) DNA-directed RNA polymerases I, II, and III subunit RPABC2 × 1 (P20435) DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 (P20436) DNA-directed RNA polymerase II subunit RPB9 × 1 (P27999) DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 (P22139) DNA-directed RNA polymerases I, II, and III subunit RPABC4 × 1 (P40422) ;RNA (5'-R(*AP*GP*GP*(5BU)P*G)-3') ; × 1 ;DNA (5'-D(*CP*TP*AP*CP*CP*GP*AP*TP*AP*AP*GP*CP*AP*GP*AP*CP*GP*AP*TP*CP*AP*CP*CP*TP*CP*GP*AP*TP*G)-3') ; × 1 ZINC ION × 8 MAGNESIUM ION × 1 与全部聚合物一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 RPB11_YEAST
Isoform —
PDB实体 9
链与序列区间 作者链 K; PDB构建体 1–120; UniProt 1–120

DNA-directed RNA polymerases I, II, and III subunit RPABC4

物种未注明

UniProt P40422

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 其他组合 异源复合物 蛋白 10 DNA 1 RNA 1 DNA-directed RNA polymerase II subunit RPB1 × 1 (P04050) DNA-directed RNA polymerase II subunit RPB2 × 1 (P08518) DNA-directed RNA polymerase II subunit RPB3 × 1 (P16370) DNA-directed RNA polymerases I, II, and III subunit RPABC1 × 1 (P20434) DNA-directed RNA polymerases I, II, and III subunit RPABC2 × 1 (P20435) DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 (P20436) DNA-directed RNA polymerase II subunit RPB9 × 1 (P27999) DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 (P22139) DNA-directed RNA polymerase II subunit RPB11 × 1 (P38902) ;RNA (5'-R(*AP*GP*GP*(5BU)P*G)-3') ; × 1 ;DNA (5'-D(*CP*TP*AP*CP*CP*GP*AP*TP*AP*AP*GP*CP*AP*GP*AP*CP*GP*AP*TP*CP*AP*CP*CP*TP*CP*GP*AP*TP*G)-3') ; × 1 ZINC ION × 8 MAGNESIUM ION × 1 与全部聚合物一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 RPAB4_YEAST
Isoform —
PDB实体 10
链与序列区间 作者链 L; PDB构建体 1–70; UniProt 1–70

页面优先展示蛋白身份、当前 assembly、共同组分、聚集状态和跨 PDB 结构链接。 链映射与序列区间收在“数据证据”中;数据库内部编号、导入时间和 assembly 操作表达式仅用于维护,因此不在读者页面展示。

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2. 结构基本信息 2. Structure Basics

条目编号 entry_id3s2d
沉积日期 deposition_date2011-05-16
结构标题 titleRNA Polymerase II Initiation Complex with a 5-nt RNA containing a 5Br-U
关键词 keywordsRNA polymerase II, initiation complex, TRANSCRIPTION-RNA-DNA complex; TRANSCRIPTION/RNA/DNA
实验方法 methodX-RAY DIFFRACTION
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3. Official assembly/model 理论 SAXS Official SAXS Profiles

页面只读取最新 assembly 计算结果。每一条曲线都对应明确的 PDB、official biological assembly 和 coordinate model。

3s2d__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

下载该曲线 .dat

3s2d__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 109 q (1/Angstrom) I(q)
100 个绘图点;横轴和纵轴均采用对数尺度。

3s2d__assembly_1__model_1 | P(r) · Pending

新版 assembly/model P(r) 尚未计算 此处仅保留位置,不展示旧数据 r (Angstrom) P(r)
P(r) 将按相同 assembly/model 分别计算和展示。
Rg(Guinier)47.74 Å
Rg(电子密度)47.18 Å
总 Rg47.49 Å
原子数28672
残基数3578
排除体积510340 ų
最大 q0.500 Å⁻¹
Assembly Model 结构单元 聚集说明 状态 CRYSOL 操作
1 1 3s2d__assembly_1__model_1 dodecameric (12) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
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4. 晶体学与实验 4. Crystallography & Experiment

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5. 实体与聚合物信息 Entities & Polymers (14)

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6. 折叠分类 (SCOP + CATH) 18 domains

CATH v4.4 (18 domains)

结构域编号 domain_id3s2dA01
类 Class class1 — Mainly Alpha
架构 Architecture architecture10 — Orthogonal Bundle
拓扑 Topology topology274 — Enzyme I; Chain A, domain 2
同源超家族 H-superfamily homologous superfamily100 — RNA polymerase Rpb1, domain 3
结构域编号 domain_id3s2dA02
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology1360 — Gyrase A; domain 2
同源超家族 H-superfamily homologous superfamily140 —
结构域编号 domain_id3s2dB04
类 Class class3 — Alpha Beta
架构 Architecture architecture90 — Alpha-Beta Complex
拓扑 Topology topology1110 — Dna-directed Rna Polymerase Ii 140kd Polypeptide; Chain: B; domain 3
同源超家族 H-superfamily homologous superfamily10 — RNA polymerase Rpb2, domain 2
结构域编号 domain_id3s2dB05
类 Class class3 — Alpha Beta
架构 Architecture architecture90 — Alpha-Beta Complex
拓扑 Topology topology1070 — Hypothetical Protein Ta0175; Chain: A, domain 2
同源超家族 H-superfamily homologous superfamily20 —
结构域编号 domain_id3s2dB06
类 Class class2 — Mainly Beta
架构 Architecture architecture40 — Beta Barrel
拓扑 Topology topology270 — Dna-directed Rna Polymerase Ii 140kd Polypeptide; Chain: B; Domain 6
同源超家族 H-superfamily homologous superfamily10 — DNA-directed RNA polymerase, subunit 2, domain 6
结构域编号 domain_id3s2dB07
类 Class class2 — Mainly Beta
架构 Architecture architecture40 — Beta Barrel
拓扑 Topology topology50 — OB fold (Dihydrolipoamide Acetyltransferase, E2P)
同源超家族 H-superfamily homologous superfamily150 — RNA polymerase II, Rpb2 subunit, wall domain
结构域编号 domain_id3s2dB08
类 Class class3 — Alpha Beta
架构 Architecture architecture90 — Alpha-Beta Complex
拓扑 Topology topology1800 — DCoH-like
同源超家族 H-superfamily homologous superfamily10 — RNA polymerase alpha subunit dimerisation domain
结构域编号 domain_id3s2dC01
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology1360 — Gyrase A; domain 2
同源超家族 H-superfamily homologous superfamily10 — RNA polymerase, RBP11-like subunit
结构域编号 domain_id3s2dC02
类 Class class2 — Mainly Beta
架构 Architecture architecture170 — Beta Complex
拓扑 Topology topology120 — RNA Polymerase Alpha Subunit; Chain A, domain 2
同源超家族 H-superfamily homologous superfamily12 — DNA-directed RNA polymerase, insert domain
结构域编号 domain_id3s2dE01
类 Class class3 — Alpha Beta
架构 Architecture architecture40 — 3-Layer(aba) Sandwich
拓扑 Topology topology1340 — Dna-directed Rna Polymerases I, Ii, And Iii 27 Kd Polypeptide; Chain: A; domain 1
同源超家族 H-superfamily homologous superfamily10 — RNA polymerase, Rpb5, N-terminal domain
结构域编号 domain_id3s2dE02
类 Class class3 — Alpha Beta
架构 Architecture architecture90 — Alpha-Beta Complex
拓扑 Topology topology940 — Eukaryotic RPB6 RNA polymerase subunit
同源超家族 H-superfamily homologous superfamily20 — RPB5-like RNA polymerase subunit
结构域编号 domain_id3s2dF00
类 Class class3 — Alpha Beta
架构 Architecture architecture90 — Alpha-Beta Complex
拓扑 Topology topology940 — Eukaryotic RPB6 RNA polymerase subunit
同源超家族 H-superfamily homologous superfamily10 — RNA polymerase subunit, RPB6/omega
结构域编号 domain_id3s2dH00
类 Class class2 — Mainly Beta
架构 Architecture architecture40 — Beta Barrel
拓扑 Topology topology50 — OB fold (Dihydrolipoamide Acetyltransferase, E2P)
同源超家族 H-superfamily homologous superfamily140 — Nucleic acid-binding proteins
结构域编号 domain_id3s2dI01
类 Class class2 — Mainly Beta
架构 Architecture architecture20 — Single Sheet
拓扑 Topology topology25 — N-terminal domain of TfIIb
同源超家族 H-superfamily homologous superfamily10 —
结构域编号 domain_id3s2dI02
类 Class class2 — Mainly Beta
架构 Architecture architecture20 — Single Sheet
拓扑 Topology topology25 — N-terminal domain of TfIIb
同源超家族 H-superfamily homologous superfamily10 —
结构域编号 domain_id3s2dJ00
类 Class class1 — Mainly Alpha
架构 Architecture architecture10 — Orthogonal Bundle
拓扑 Topology topology10 — Arc Repressor Mutant, subunit A
同源超家族 H-superfamily homologous superfamily60 — Homeodomain-like
结构域编号 domain_id3s2dK00
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology1360 — Gyrase A; domain 2
同源超家族 H-superfamily homologous superfamily10 — RNA polymerase, RBP11-like subunit
结构域编号 domain_id3s2dL00
类 Class class2 — Mainly Beta
架构 Architecture architecture20 — Single Sheet
拓扑 Topology topology28 — Rubrerythrin, domain 2
同源超家族 H-superfamily homologous superfamily30 — RNA polymerase ii, chain L
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7. 引用文献 (1)