3uro

Poliovirus receptor CD155 D1D2

Method: X-RAY DIFFRACTION D_max: 91.0 Å Quality: REASONABLE

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1. Protein Identity and Related Structures Protein Identity & Related Structures

Poliovirus receptor

Homo sapiens

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein monomer Monomer Protein × 1 PDB declaration: monomeric（1） Consistent with protein copy count	Chain R； UniProt 29–243	Fragment：poliovirus receptor CD155 D1D2 (UNP Residues 29-243) Mutation：N105D, N120S, N188Q, N218Q, N237S	No other associated polymer	X-RAY DIFFRACTION X-ray crystallization conditions：VAPOR DIFFUSION, HANGING DROP；pH 8.5；298 K；100 mM MgSO4, 6.8 M NH4NO3, 100 mM Tris buffer, pH 8.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K	Resolution 3.50 Å R-free 0.341
2	Protein homooligomer Homooligomer Protein × 2 PDB declaration: dimeric（2） Consistent with protein copy count	Chain R； UniProt 29–243	Fragment：poliovirus receptor CD155 D1D2 (UNP Residues 29-243) Mutation：N105D, N120S, N188Q, N218Q, N237S	No other associated polymer	X-RAY DIFFRACTION X-ray crystallization conditions：VAPOR DIFFUSION, HANGING DROP；pH 8.5；298 K；100 mM MgSO4, 6.8 M NH4NO3, 100 mM Tris buffer, pH 8.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K	Resolution 3.50 Å R-free 0.341

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB	Difference from Current Entry 3URO	Assembly / Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Non-polymers	Method and Experimental Conditions	Structure Quality
1DGI Cryo-EM structure of human poliovirus(serotype 1)complexed with three domain CD155 Deposited 1999-11-24	Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 300 PDB declaration: 300-MERIC	Chain R 28–329（302 aa） Fragment：THREE EXTRACELLULAR DOMAINS OF CD155	Not recorded	No recorded non-water small molecule	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions POLIOVIRUS WAS INCUBATED WITH CD155-AP FOR 1 HOURS AT 4 DEGREES CELSIUS (277 KELVIN) USING A EIGHT-FOLD EXCESS OF CD155-AP FOR EACH OF THE SIXTY POSSIBLE BINDING SITES PER VIRION. AFTER INCUBATION, SAMPLES WERE PREPARED AS THIN LAYERS OF VITREOUS ICE AND MAINTAINED AT NEAR LIQUID NITROGEN TEMPERATURE IN THE ELECTRON MICROSCOPE WITH A GATAN 626 CRYOTRANSFER HOLDER. X-ray crystallization conditions ELECTRON MICROSCOPY RECONSTRUCTION；pH 7.5；WARNING: THIS IS AN ELECTRON MICROSCOPY MODEL DEPOSITION. CRYO-EM INFORMATION HAS BEEN INCLUDED IN THE FORM OF REMARK 250 RECORDS AT THE TOP OF THE PDB COORDINATE FILE., pH 7.5, ELECTRON MICROSCOPY RECONSTRUCTION	Resolution 22.00 Å
1DGI Cryo-EM structure of human poliovirus(serotype 1)complexed with three domain CD155 Deposited 1999-11-24	Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric	Chain R 28–329（302 aa） Fragment：THREE EXTRACELLULAR DOMAINS OF CD155	Not recorded	No recorded non-water small molecule	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions POLIOVIRUS WAS INCUBATED WITH CD155-AP FOR 1 HOURS AT 4 DEGREES CELSIUS (277 KELVIN) USING A EIGHT-FOLD EXCESS OF CD155-AP FOR EACH OF THE SIXTY POSSIBLE BINDING SITES PER VIRION. AFTER INCUBATION, SAMPLES WERE PREPARED AS THIN LAYERS OF VITREOUS ICE AND MAINTAINED AT NEAR LIQUID NITROGEN TEMPERATURE IN THE ELECTRON MICROSCOPE WITH A GATAN 626 CRYOTRANSFER HOLDER. X-ray crystallization conditions ELECTRON MICROSCOPY RECONSTRUCTION；pH 7.5；WARNING: THIS IS AN ELECTRON MICROSCOPY MODEL DEPOSITION. CRYO-EM INFORMATION HAS BEEN INCLUDED IN THE FORM OF REMARK 250 RECORDS AT THE TOP OF THE PDB COORDINATE FILE., pH 7.5, ELECTRON MICROSCOPY RECONSTRUCTION	Resolution 22.00 Å
1DGI Cryo-EM structure of human poliovirus(serotype 1)complexed with three domain CD155 Deposited 1999-11-24	Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 3 Protein heterocomplex Heteromer；Protein × 25 PDB declaration: 25-meric	Chain R 28–329（302 aa） Fragment：THREE EXTRACELLULAR DOMAINS OF CD155	Not recorded	No recorded non-water small molecule	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions POLIOVIRUS WAS INCUBATED WITH CD155-AP FOR 1 HOURS AT 4 DEGREES CELSIUS (277 KELVIN) USING A EIGHT-FOLD EXCESS OF CD155-AP FOR EACH OF THE SIXTY POSSIBLE BINDING SITES PER VIRION. AFTER INCUBATION, SAMPLES WERE PREPARED AS THIN LAYERS OF VITREOUS ICE AND MAINTAINED AT NEAR LIQUID NITROGEN TEMPERATURE IN THE ELECTRON MICROSCOPE WITH A GATAN 626 CRYOTRANSFER HOLDER. X-ray crystallization conditions ELECTRON MICROSCOPY RECONSTRUCTION；pH 7.5；WARNING: THIS IS AN ELECTRON MICROSCOPY MODEL DEPOSITION. CRYO-EM INFORMATION HAS BEEN INCLUDED IN THE FORM OF REMARK 250 RECORDS AT THE TOP OF THE PDB COORDINATE FILE., pH 7.5, ELECTRON MICROSCOPY RECONSTRUCTION	Resolution 22.00 Å
1DGI Cryo-EM structure of human poliovirus(serotype 1)complexed with three domain CD155 Deposited 1999-11-24	Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 4 Protein heterocomplex Heteromer；Protein × 30 PDB declaration: 30-meric	Chain R 28–329（302 aa） Fragment：THREE EXTRACELLULAR DOMAINS OF CD155	Not recorded	No recorded non-water small molecule	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions POLIOVIRUS WAS INCUBATED WITH CD155-AP FOR 1 HOURS AT 4 DEGREES CELSIUS (277 KELVIN) USING A EIGHT-FOLD EXCESS OF CD155-AP FOR EACH OF THE SIXTY POSSIBLE BINDING SITES PER VIRION. AFTER INCUBATION, SAMPLES WERE PREPARED AS THIN LAYERS OF VITREOUS ICE AND MAINTAINED AT NEAR LIQUID NITROGEN TEMPERATURE IN THE ELECTRON MICROSCOPE WITH A GATAN 626 CRYOTRANSFER HOLDER. X-ray crystallization conditions ELECTRON MICROSCOPY RECONSTRUCTION；pH 7.5；WARNING: THIS IS AN ELECTRON MICROSCOPY MODEL DEPOSITION. CRYO-EM INFORMATION HAS BEEN INCLUDED IN THE FORM OF REMARK 250 RECORDS AT THE TOP OF THE PDB COORDINATE FILE., pH 7.5, ELECTRON MICROSCOPY RECONSTRUCTION	Resolution 22.00 Å
1DGI Cryo-EM structure of human poliovirus(serotype 1)complexed with three domain CD155 Deposited 1999-11-24	Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 5 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric	Chain R 28–329（302 aa） Fragment：THREE EXTRACELLULAR DOMAINS OF CD155	Not recorded	No recorded non-water small molecule	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions POLIOVIRUS WAS INCUBATED WITH CD155-AP FOR 1 HOURS AT 4 DEGREES CELSIUS (277 KELVIN) USING A EIGHT-FOLD EXCESS OF CD155-AP FOR EACH OF THE SIXTY POSSIBLE BINDING SITES PER VIRION. AFTER INCUBATION, SAMPLES WERE PREPARED AS THIN LAYERS OF VITREOUS ICE AND MAINTAINED AT NEAR LIQUID NITROGEN TEMPERATURE IN THE ELECTRON MICROSCOPE WITH A GATAN 626 CRYOTRANSFER HOLDER. X-ray crystallization conditions ELECTRON MICROSCOPY RECONSTRUCTION；pH 7.5；WARNING: THIS IS AN ELECTRON MICROSCOPY MODEL DEPOSITION. CRYO-EM INFORMATION HAS BEEN INCLUDED IN THE FORM OF REMARK 250 RECORDS AT THE TOP OF THE PDB COORDINATE FILE., pH 7.5, ELECTRON MICROSCOPY RECONSTRUCTION	Resolution 22.00 Å
1NN8 CryoEM structure of poliovirus receptor bound to poliovirus Deposited 2003-01-13	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 420 PDB declaration: 420-MERIC	Chain R 28–329（302 aa） Chain S 28–329（302 aa） Chain T 28–329（302 aa）	Not recorded	MYR MYRISTIC ACID × 60	ELECTRON MICROSCOPY mmCIF provides none of the parsed conditions	Resolution 15.00 Å
1NN8 CryoEM structure of poliovirus receptor bound to poliovirus Deposited 2003-01-13	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 7 PDB declaration: heptameric	Chain R 28–329（302 aa） Chain S 28–329（302 aa） Chain T 28–329（302 aa）	Not recorded	MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY mmCIF provides none of the parsed conditions	Resolution 15.00 Å
1NN8 CryoEM structure of poliovirus receptor bound to poliovirus Deposited 2003-01-13	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 3 Protein heterocomplex Heteromer；Protein × 35 PDB declaration: 35-meric	Chain R 28–329（302 aa） Chain S 28–329（302 aa） Chain T 28–329（302 aa）	Not recorded	MYR MYRISTIC ACID × 5	ELECTRON MICROSCOPY mmCIF provides none of the parsed conditions	Resolution 15.00 Å
1NN8 CryoEM structure of poliovirus receptor bound to poliovirus Deposited 2003-01-13	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 4 Protein heterocomplex Heteromer；Protein × 42 PDB declaration: 42-meric	Chain R 28–329（302 aa） Chain S 28–329（302 aa） Chain T 28–329（302 aa）	Not recorded	MYR MYRISTIC ACID × 6	ELECTRON MICROSCOPY mmCIF provides none of the parsed conditions	Resolution 15.00 Å
1NN8 CryoEM structure of poliovirus receptor bound to poliovirus Deposited 2003-01-13	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 5 Protein heterocomplex Heteromer；Protein × 7 PDB declaration: heptameric	Chain R 28–329（302 aa） Chain S 28–329（302 aa） Chain T 28–329（302 aa）	Not recorded	MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY mmCIF provides none of the parsed conditions	Resolution 15.00 Å
3EPC CryoEM structure of poliovirus receptor bound to poliovirus type 1 Deposited 2008-09-29	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 300 PDB declaration: 300-MERIC	Chain R 30–242（213 aa） Fragment：Poliovirus receptor CD155 D1D2	Mutation：N105D, N120S, N188Q, N218Q, N237S	SPH SPHINGOSINE × 60 MYR MYRISTIC ACID × 60	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5；10mM Tris-HCl, 20mM NaCl cryo-EM vitrification conditions Cryogen ETHANE	Resolution 8.00 Å
3EPC CryoEM structure of poliovirus receptor bound to poliovirus type 1 Deposited 2008-09-29	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric	Chain R 30–242（213 aa） Fragment：Poliovirus receptor CD155 D1D2	Mutation：N105D, N120S, N188Q, N218Q, N237S	SPH SPHINGOSINE × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5；10mM Tris-HCl, 20mM NaCl cryo-EM vitrification conditions Cryogen ETHANE	Resolution 8.00 Å
3EPC CryoEM structure of poliovirus receptor bound to poliovirus type 1 Deposited 2008-09-29	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 3 Protein heterocomplex Heteromer；Protein × 25 PDB declaration: 25-meric	Chain R 30–242（213 aa） Fragment：Poliovirus receptor CD155 D1D2	Mutation：N105D, N120S, N188Q, N218Q, N237S	SPH SPHINGOSINE × 5 MYR MYRISTIC ACID × 5	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5；10mM Tris-HCl, 20mM NaCl cryo-EM vitrification conditions Cryogen ETHANE	Resolution 8.00 Å
3EPC CryoEM structure of poliovirus receptor bound to poliovirus type 1 Deposited 2008-09-29	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 4 Protein heterocomplex Heteromer；Protein × 30 PDB declaration: 30-meric	Chain R 30–242（213 aa） Fragment：Poliovirus receptor CD155 D1D2	Mutation：N105D, N120S, N188Q, N218Q, N237S	SPH SPHINGOSINE × 6 MYR MYRISTIC ACID × 6	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5；10mM Tris-HCl, 20mM NaCl cryo-EM vitrification conditions Cryogen ETHANE	Resolution 8.00 Å
3EPC CryoEM structure of poliovirus receptor bound to poliovirus type 1 Deposited 2008-09-29	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 5 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric	Chain R 30–242（213 aa） Fragment：Poliovirus receptor CD155 D1D2	Mutation：N105D, N120S, N188Q, N218Q, N237S	SPH SPHINGOSINE × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5；10mM Tris-HCl, 20mM NaCl cryo-EM vitrification conditions Cryogen ETHANE	Resolution 8.00 Å
3EPD CryoEM structure of poliovirus receptor bound to poliovirus type 3 Deposited 2008-09-29	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 360 PDB declaration: 360-MERIC	Chain R 30–242（213 aa） Fragment：Poliovirus receptor CD155 D1D2	Mutation：N105D, N120S, N188Q, N218Q, N237S	SPH SPHINGOSINE × 60 MYR MYRISTIC ACID × 60	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5；10mM Tris-HCl, 20mM NaCl cryo-EM vitrification conditions Cryogen ETHANE	Resolution 9.00 Å
3EPD CryoEM structure of poliovirus receptor bound to poliovirus type 3 Deposited 2008-09-29	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric	Chain R 30–242（213 aa） Fragment：Poliovirus receptor CD155 D1D2	Mutation：N105D, N120S, N188Q, N218Q, N237S	SPH SPHINGOSINE × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5；10mM Tris-HCl, 20mM NaCl cryo-EM vitrification conditions Cryogen ETHANE	Resolution 9.00 Å
3EPD CryoEM structure of poliovirus receptor bound to poliovirus type 3 Deposited 2008-09-29	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 3 Protein heterocomplex Heteromer；Protein × 30 PDB declaration: 30-meric	Chain R 30–242（213 aa） Fragment：Poliovirus receptor CD155 D1D2	Mutation：N105D, N120S, N188Q, N218Q, N237S	SPH SPHINGOSINE × 5 MYR MYRISTIC ACID × 5	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5；10mM Tris-HCl, 20mM NaCl cryo-EM vitrification conditions Cryogen ETHANE	Resolution 9.00 Å
3EPD CryoEM structure of poliovirus receptor bound to poliovirus type 3 Deposited 2008-09-29	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 4 Protein heterocomplex Heteromer；Protein × 36 PDB declaration: 36-meric	Chain R 30–242（213 aa） Fragment：Poliovirus receptor CD155 D1D2	Mutation：N105D, N120S, N188Q, N218Q, N237S	SPH SPHINGOSINE × 6 MYR MYRISTIC ACID × 6	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5；10mM Tris-HCl, 20mM NaCl cryo-EM vitrification conditions Cryogen ETHANE	Resolution 9.00 Å
3EPD CryoEM structure of poliovirus receptor bound to poliovirus type 3 Deposited 2008-09-29	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 5 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric	Chain R 30–242（213 aa） Fragment：Poliovirus receptor CD155 D1D2	Mutation：N105D, N120S, N188Q, N218Q, N237S	SPH SPHINGOSINE × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5；10mM Tris-HCl, 20mM NaCl cryo-EM vitrification conditions Cryogen ETHANE	Resolution 9.00 Å
3EPF CryoEM structure of poliovirus receptor bound to poliovirus type 2 Deposited 2008-09-29	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 300 PDB declaration: 300-MERIC	Chain R 30–242（213 aa） Fragment：Poliovirus receptor CD155 D1D2	Mutation：N105D, N120S, N188Q, N218Q, N237S	SC4 1[2-CHLORO-4-METHOXY-PHENYL-OXYMETHYL]-4-[2,6-DICHLORO-PHENYL-OXYMETHYL]-BENZENE × 60 MYR MYRISTIC ACID × 60	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5；10mM Tris-HCl, 20mM NaCl cryo-EM vitrification conditions Cryogen ETHANE	Resolution 9.00 Å
3EPF CryoEM structure of poliovirus receptor bound to poliovirus type 2 Deposited 2008-09-29	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric	Chain R 30–242（213 aa） Fragment：Poliovirus receptor CD155 D1D2	Mutation：N105D, N120S, N188Q, N218Q, N237S	SC4 1[2-CHLORO-4-METHOXY-PHENYL-OXYMETHYL]-4-[2,6-DICHLORO-PHENYL-OXYMETHYL]-BENZENE × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5；10mM Tris-HCl, 20mM NaCl cryo-EM vitrification conditions Cryogen ETHANE	Resolution 9.00 Å
3EPF CryoEM structure of poliovirus receptor bound to poliovirus type 2 Deposited 2008-09-29	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 3 Protein heterocomplex Heteromer；Protein × 25 PDB declaration: 25-meric	Chain R 30–242（213 aa） Fragment：Poliovirus receptor CD155 D1D2	Mutation：N105D, N120S, N188Q, N218Q, N237S	SC4 1[2-CHLORO-4-METHOXY-PHENYL-OXYMETHYL]-4-[2,6-DICHLORO-PHENYL-OXYMETHYL]-BENZENE × 5 MYR MYRISTIC ACID × 5	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5；10mM Tris-HCl, 20mM NaCl cryo-EM vitrification conditions Cryogen ETHANE	Resolution 9.00 Å
3EPF CryoEM structure of poliovirus receptor bound to poliovirus type 2 Deposited 2008-09-29	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 4 Protein heterocomplex Heteromer；Protein × 30 PDB declaration: 30-meric	Chain R 30–242（213 aa） Fragment：Poliovirus receptor CD155 D1D2	Mutation：N105D, N120S, N188Q, N218Q, N237S	SC4 1[2-CHLORO-4-METHOXY-PHENYL-OXYMETHYL]-4-[2,6-DICHLORO-PHENYL-OXYMETHYL]-BENZENE × 6 MYR MYRISTIC ACID × 6	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5；10mM Tris-HCl, 20mM NaCl cryo-EM vitrification conditions Cryogen ETHANE	Resolution 9.00 Å
3EPF CryoEM structure of poliovirus receptor bound to poliovirus type 2 Deposited 2008-09-29	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 5 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric	Chain R 30–242（213 aa） Fragment：Poliovirus receptor CD155 D1D2	Mutation：N105D, N120S, N188Q, N218Q, N237S	SC4 1[2-CHLORO-4-METHOXY-PHENYL-OXYMETHYL]-4-[2,6-DICHLORO-PHENYL-OXYMETHYL]-BENZENE × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5；10mM Tris-HCl, 20mM NaCl cryo-EM vitrification conditions Cryogen ETHANE	Resolution 9.00 Å
3J8F Cryo-EM reconstruction of poliovirus-receptor complex Deposited 2014-10-20	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Other combination Heteromer；Protein × 300 PDB declaration: 300-meric	Chain 7 1–417（417 aa）	Not recorded	NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 60	ELECTRON MICROSCOPY cryo-EM buffer PBS；pH 7；PBS cryo-EM vitrification conditions Sample mixed and frozen within 2 minutes.；120 K；Cryogen ETHANE；Sample mixed and frozen within 2 minutes before plunging into liquid ethane.	Resolution 3.70 Å
3J8F Cryo-EM reconstruction of poliovirus-receptor complex Deposited 2014-10-20	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Other combination Heteromer；Protein × 5 PDB declaration: pentameric	Chain 7 1–417（417 aa）	Not recorded	NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1	ELECTRON MICROSCOPY cryo-EM buffer PBS；pH 7；PBS cryo-EM vitrification conditions Sample mixed and frozen within 2 minutes.；120 K；Cryogen ETHANE；Sample mixed and frozen within 2 minutes before plunging into liquid ethane.	Resolution 3.70 Å
3J8F Cryo-EM reconstruction of poliovirus-receptor complex Deposited 2014-10-20	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 3 Other combination Heteromer；Protein × 25 PDB declaration: 25-meric	Chain 7 1–417（417 aa）	Not recorded	NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 5	ELECTRON MICROSCOPY cryo-EM buffer PBS；pH 7；PBS cryo-EM vitrification conditions Sample mixed and frozen within 2 minutes.；120 K；Cryogen ETHANE；Sample mixed and frozen within 2 minutes before plunging into liquid ethane.	Resolution 3.70 Å
3J8F Cryo-EM reconstruction of poliovirus-receptor complex Deposited 2014-10-20	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 4 Other combination Heteromer；Protein × 30 PDB declaration: 30-meric	Chain 7 1–417（417 aa）	Not recorded	NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 6	ELECTRON MICROSCOPY cryo-EM buffer PBS；pH 7；PBS cryo-EM vitrification conditions Sample mixed and frozen within 2 minutes.；120 K；Cryogen ETHANE；Sample mixed and frozen within 2 minutes before plunging into liquid ethane.	Resolution 3.70 Å
3J8F Cryo-EM reconstruction of poliovirus-receptor complex Deposited 2014-10-20	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 5 Other combination Heteromer；Protein × 5 PDB declaration: pentameric	Chain 7 1–417（417 aa）	Not recorded	NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1	ELECTRON MICROSCOPY cryo-EM buffer PBS；pH 7；PBS cryo-EM vitrification conditions Sample mixed and frozen within 2 minutes.；120 K；Cryogen ETHANE；Sample mixed and frozen within 2 minutes before plunging into liquid ethane.	Resolution 3.70 Å
3J9F Poliovirus complexed with soluble, deglycosylated poliovirus receptor (Pvr) at 4 degrees C Deposited 2015-01-15	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Other combination Heteromer；Protein × 420 PDB declaration: 420-meric	Chain 7 28–143（116 aa） Fragment：SEE REMARK 999 Chain 8 142–243（102 aa） Fragment：SEE REMARK 999 Chain 9 242–333（92 aa） Fragment：SEE REMARK 999	Not recorded	PLM PALMITIC ACID × 60 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 60	ELECTRON MICROSCOPY cryo-EM vitrification conditions Cryogen ETHANE	Resolution 9.00 Å
3J9F Poliovirus complexed with soluble, deglycosylated poliovirus receptor (Pvr) at 4 degrees C Deposited 2015-01-15	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Other combination Heteromer；Protein × 7 PDB declaration: heptameric	Chain 7 28–143（116 aa） Fragment：SEE REMARK 999 Chain 8 142–243（102 aa） Fragment：SEE REMARK 999 Chain 9 242–333（92 aa） Fragment：SEE REMARK 999	Not recorded	PLM PALMITIC ACID × 1 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1	ELECTRON MICROSCOPY cryo-EM vitrification conditions Cryogen ETHANE	Resolution 9.00 Å
3J9F Poliovirus complexed with soluble, deglycosylated poliovirus receptor (Pvr) at 4 degrees C Deposited 2015-01-15	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 3 Other combination Heteromer；Protein × 35 PDB declaration: 35-meric	Chain 7 28–143（116 aa） Fragment：SEE REMARK 999 Chain 8 142–243（102 aa） Fragment：SEE REMARK 999 Chain 9 242–333（92 aa） Fragment：SEE REMARK 999	Not recorded	PLM PALMITIC ACID × 5 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 5	ELECTRON MICROSCOPY cryo-EM vitrification conditions Cryogen ETHANE	Resolution 9.00 Å
3J9F Poliovirus complexed with soluble, deglycosylated poliovirus receptor (Pvr) at 4 degrees C Deposited 2015-01-15	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 4 Other combination Heteromer；Protein × 42 PDB declaration: 42-meric	Chain 7 28–143（116 aa） Fragment：SEE REMARK 999 Chain 8 142–243（102 aa） Fragment：SEE REMARK 999 Chain 9 242–333（92 aa） Fragment：SEE REMARK 999	Not recorded	PLM PALMITIC ACID × 6 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 6	ELECTRON MICROSCOPY cryo-EM vitrification conditions Cryogen ETHANE	Resolution 9.00 Å
3J9F Poliovirus complexed with soluble, deglycosylated poliovirus receptor (Pvr) at 4 degrees C Deposited 2015-01-15	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 5 Other combination Heteromer；Protein × 7 PDB declaration: heptameric	Chain 7 28–143（116 aa） Fragment：SEE REMARK 999 Chain 8 142–243（102 aa） Fragment：SEE REMARK 999 Chain 9 242–333（92 aa） Fragment：SEE REMARK 999	Not recorded	PLM PALMITIC ACID × 1 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1	ELECTRON MICROSCOPY cryo-EM vitrification conditions Cryogen ETHANE	Resolution 9.00 Å
3UDW Crystal structure of the immunoreceptor TIGIT in complex with Poliovirus receptor (PVR/CD155/necl-5) D1 domain Deposited 2011-10-28	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric	Chain C 28–145（118 aa） Fragment：PVR, UNP residues 28-145 Chain D 28–145（118 aa） Fragment：PVR, UNP residues 28-145	Not recorded	NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；298 K；0.1 M Ammonium acetate 0.1 M Bis-Tris pH 5.5 17% PEG 10000, VAPOR DIFFUSION, HANGING DROP, temperature 298K	Resolution 2.90 Å R-free 0.287
4FQP Crystal structure of human Nectin-like 5 full ectodomain (D1-D3) Deposited 2012-06-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Other combination Monomer；Protein × 1 PDB declaration: monomeric	Chain A 28–334（307 aa） Fragment：ectodomain (D1-D3, UNP residues 28-334)	Not recorded	NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 9；293.15 K；55% v/v tacsimate, 0.1 M Bicine, pH 9.0, with additional 10% tacsimate as cryoprotectant, VAPOR DIFFUSION, HANGING DROP, temperature 293.15K	Resolution 3.60 Å R-free 0.272
6ARQ Crystal structure of CD96 (D1) bound to CD155/necl-5 (D1-3) Deposited 2017-08-23	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Other combination Heteromer；Protein × 2 PDB declaration: dimeric	Chain D 28–334（307 aa）	Not recorded	NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；32% (v/v) Jeffamine ED-2001 0.1M HEPES pH7.3	Resolution 2.88 Å R-free 0.252
6ISC complex structure of mCD226-ecto and hCD155-D1 Deposited 2018-11-16	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric	Chain B 28–145（118 aa）	Not recorded	NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；291 K；0.1 M Tris (pH 8.0), 0.15 M ammonium sulfate, and 15% (w/v) PEG4000	Resolution 2.20 Å R-free 0.265
6O3O Structure of human DNAM-1 (CD226) bound to nectin-like protein-5 (necl-5) Deposited 2019-02-27	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Other combination Heteromer；Protein × 4 PDB declaration: tetrameric	Chain C 28–334（307 aa） Chain D 28–334（307 aa）	Not recorded	NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 12 SO4 SULFATE ION × 3	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；20% PEG3350, 0.18M K2SO4, 10mM EDTA	Resolution 2.80 Å R-free 0.231

12 other PDB entries and 40 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence

UniProt name	PVR_HUMAN
Isoform	—
PDB entities	1
Chains and sequence ranges	Author chain R； PDBConstruct 1–215； UniProt 29–243

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

SAXS scattering curve SAXS Profile

P(r) Distance Distribution P(r) Distribution

Download Download SAXS (.dat) P(r) (.pr.out) CIF

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2. Structure Basics 2. Structure Basics

Entry ID entry_id	3uro
Deposition date deposition_date	2011-11-22
Structure title title	Poliovirus receptor CD155 D1D2
Keywords keywords	;poliovirus receptor ectodomain, Immunoglobulin Super Family, Cell adhesion, Cell membrane, Glycoprotein, Host-virus interaction, Immunoglobulin domain, Membrane, Receptor, Secreted, Transmembrane, VIRAL PROTEIN ;; VIRAL PROTEIN
Experimental Method method	X-RAY DIFFRACTION

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3. SAXS Parameters (CRYSOL theoretical calculation) 3. SAXS Parameters (CRYSOL)

Radius of gyration Rg (Guinier) rg_guinier	25.47 Å
Radius of gyration Rg (electron density) rg_electron	25.75 Å
Forward intensity I(0) i0	9605660.00
Molecular weight molecular_weight	23291.0 kDa
Excluded volume excluded_volume	29171 Å³
Envelope volume envelope_volume	36193 Å³
Hydration-shell volume shell_volume	13678 Å³
Envelope diameter envelope_diameter	93.4 Å
Shell Rg shell_rg	28.47 Å
Envelope Rg envelope_rg	25.89 Å
Shape Rg shape_rg	25.73 Å
Total Rg total_rg	26.15 Å
Total atoms total_atoms	1638
Residues n_residues	213
Spherical-harmonic order n_harmonics	20
q range q_range	— – 0.5000 Å⁻¹
Data points n_points	101
Shell type shell_type	directional
Solvent electron density solvent_density	0.3340 e/Å³
Shell contrast contrast_shell	0.0300 e/Å³
CRYSOL version crysol_version	4.1.3

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4. P(r) Distance Distribution (GNOM inversion) 4. P(r) Analysis (GNOM)

Maximum dimension Dmax dmax	91.0 Å
Rg (real space) rg_real	25.91 Å
Rg uncertainty (real space) rg_real_error	1.14 Å
I(0) (real space) i0_real	9.6060e+06
I(0) uncertainty (real space) i0_real_error	1.4970e+05
Rg (reciprocal space) rg_reciprocal	25.78 Å
I(0) (reciprocal space) i0_reciprocal	9605000.0000
Solution quality estimate total_estimate	0.7035
Solution quality rating solution_quality	REASONABLE a REASONABLE solution
P(r) peaks n_peaks	2
Primary peak position r_peak_primary	17.6 Å
Skewness Skewness skewness	0.580
Kurtosis Kurtosis kurtosis	-0.534
Angular range angular_range	— – 0.3100 Å⁻¹
Current regularization parameter α current_alpha	0.0000
Highest regularization parameter α highest_alpha	1441000.0000
Real-space data points n_real_points	63
GNOM version gnom_version	4.1.3
Quality Criteria quality_criteria	AN1: 0.000; Oscil: 0.339; Stabil: 0.999; Sysdev: 1.000; Positv: 1.000; Valcen: 0.131; Smooth: 0.994

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5. Crystallography and Experiment 5. Crystallography & Experiment

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6. Entities and Polymers Entities & Polymers (1)

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7. Fold Classification (SCOP + CATH) 2 domains

CATH v4.4 (2 domains)

Domain ID domain_id	3uroR01
Class class	2 — Mainly Beta
Architecture architecture	60 — Sandwich
Topology topology	40 — Immunoglobulin-like
Homologous superfamily homologous superfamily	10 — Immunoglobulins

Domain ID domain_id	3uroR02
Class class	2 — Mainly Beta
Architecture architecture	60 — Sandwich
Topology topology	40 — Immunoglobulin-like
Homologous superfamily homologous superfamily	10 — Immunoglobulins

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8. Citations (1)

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Unit-cell length a length_a	84.307 Å
Unit-cell length b length_b	84.307 Å
Unit-cell length c length_c	117.219 Å
Unit-cell angle α angle_alpha	90.00 °
Unit-cell angle β angle_beta	90.00 °
Unit-cell angle γ angle_gamma	90.00 °
Molecules per unit cell Z z_pdb	8

Space group space_group	P 41 21 2
Space-group number int_tables_number	92
Crystal system crystal_system	—

Resolution resolution	3.501 Å
Low-resolution limit resolution_low	35.892 Å
R factor r_factor	0.3066
R_work r_work	0.3048
R_free r_free	0.3414

Description description	Poliovirus receptor
Molecular weight formula_weight	24355.6 kDa
Mutation mutation	N105D, N120S, N188Q, N218Q, N237S
Source method src_method	man
Copy count entity_count	1

Polymer type type	polypeptide(L)
Chain IDs strand_id	R
Atom count atom_count	1638

Poliovirus receptor CD155 D1D2

1. Protein Identity and Related Structures Protein Identity & Related Structures

Poliovirus receptor

State in the Current Structure

Other States of the Same Protein in the Database

SAXS scattering curve SAXS Profile

P(r) Distance Distribution P(r) Distribution

2. Structure Basics 2. Structure Basics

3. SAXS Parameters (CRYSOL theoretical calculation) 3. SAXS Parameters (CRYSOL)

4. P(r) Distance Distribution (GNOM inversion) 4. P(r) Analysis (GNOM)

5. Crystallography and Experiment 5. Crystallography & Experiment

Unit cell Unit Cell

Symmetry Symmetry

Refinement Refinement

Diffraction experiment Diffraction

6. Entities and Polymers Entities & Polymers (1)

Entity 1 Entity 1 polymer

Polymer Polymer

来源 Source

7. Fold Classification (SCOP + CATH) 2 domains

CATH v4.4 (2 domains)

8. Citations (1)

9. Files and Curves (10)

Files (7)

Curves (3)

来源生物 organism	Homo sapiens
通用名 common_name	human
NCBI Class编号 ncbi_taxonomy_id	9606
宿主生物 host_organism	Homo sapiens

fit	/app/data/saxs_computation/ur/3uro/3uro.fit
pddf	/app/data/pr_computation/ur/3uro/3uro.pr.out
profile	/app/data/saxs_computation/ur/3uro/3uro.dat