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4asb

The structure of modified benzoquinone ansamycins bound to yeast N- terminal Hsp90

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

ATP-DEPENDENT MOLECULAR CHAPERONE HSP82

SACCHAROMYCES CEREVISIAE

UniProt P02829

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein monomer Monomer Protein 1 ;(4E,6E,8S,9R,10E,12R,13R,14S,16R)-19-{[2-(dimethylamino)ethyl]amino}-13-hydroxy-8,14-dimethoxy-4,10,12,16,21-pentamethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl carbamate ; × 1 water × 1 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1hk7 1hk7 1zw9 1zwh 2akp 2akp 2brc 2bre 2bre 2fxs 2iws 2iwu

23 assemblies; showing the first 12

Homodimer
1a4h 1ah6 1ah8 1am1 1amw 1bgq 2akp 2akp 2cgf 2wep 2weq 2wer

28 assemblies; showing the first 12

Homotetramer

None

Other homooligomers
2cge

1 assemblies

Heteromeric or nucleic-acid complex
1us7 1usu 1usv 1usv 1usv 1usv 2cg9 2lsv 3fp2 9q8o

10 assemblies

View Construct and Data Evidence
UniProt name HSP82_YEAST
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–220； UniProt 1–220

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id4asb
Deposition date deposition_date2012-04-30
Structure title titleThe structure of modified benzoquinone ansamycins bound to yeast N- terminal Hsp90
Keywords keywordsCHAPERONE, INHIBITION, ANSAMYCIN; CHAPERONE
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

4asb__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

4asb__assembly_1__model_1 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

4asb__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）18.10 Å
Rg (electron density)16.78 Å
Total Rg17.85 Å
Atom count1724
Residues213
Excluded volume31005 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 4asb__assembly_1__model_1 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (3)

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6. Fold Classification (SCOP + CATH) 2 domains

SCOP 2.08 (1 domains)

Domain ID domain_idd4asba_
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.122 — ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily Superfamily superfamilyd.122.1 — ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family Family familyd.122.1.1 — Heat shock protein 90, HSP90, N-terminal domain

CATH v4.4 (1 domains)

Domain ID domain_id4asbA00
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology565 — Heat Shock Protein 90
Homologous superfamily homologous superfamily10 — Histidine kinase-like ATPase, C-terminal domain
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7. Citations (1)