4ayb

RNAP at 3.2Ang

Method: X-RAY DIFFRACTION

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1. Protein Identity and Related Structures Protein Identity & Related Structures

DNA-DIRECTED RNA POLYMERASE

OrganismNot specified

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 13	DNA-DIRECTED RNA POLYMERASE × 1 （B8YB55） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB54） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB56） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB57） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB58） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB59） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB60） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB61） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB62） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB63） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB64） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB65） ZINC ION × 10 MAGNESIUM ION × 1 IRON/SULFUR CLUSTER × 1	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	B8YB53_SULSH
Isoform	—
PDB entities	1
Chains and sequence ranges	Author chain A； PDBConstruct 1–880； UniProt 1–880

DNA-DIRECTED RNA POLYMERASE

OrganismNot specified

UniProt B8YB55

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 13	DNA-DIRECTED RNA POLYMERASE × 1 （B8YB53） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB54） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB56） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB57） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB58） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB59） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB60） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB61） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB62） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB63） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB64） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB65） ZINC ION × 10 MAGNESIUM ION × 1 IRON/SULFUR CLUSTER × 1	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	B8YB55_SULSH
Isoform	—
PDB entities	2
Chains and sequence ranges	Author chain B； PDBConstruct 1–1131； UniProt 1–1131

DNA-DIRECTED RNA POLYMERASE

OrganismNot specified

UniProt B8YB54

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 13	DNA-DIRECTED RNA POLYMERASE × 1 （B8YB53） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB55） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB56） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB57） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB58） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB59） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB60） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB61） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB62） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB63） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB64） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB65） ZINC ION × 10 MAGNESIUM ION × 1 IRON/SULFUR CLUSTER × 1	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	B8YB54_SULSH
Isoform	—
PDB entities	3
Chains and sequence ranges	Author chain C； PDBConstruct 1–395； UniProt 1–395

DNA-DIRECTED RNA POLYMERASE

OrganismNot specified

UniProt B8YB56

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 13	DNA-DIRECTED RNA POLYMERASE × 1 （B8YB53） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB55） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB54） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB57） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB58） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB59） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB60） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB61） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB62） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB63） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB64） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB65） ZINC ION × 10 MAGNESIUM ION × 1 IRON/SULFUR CLUSTER × 1	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	B8YB56_SULSH
Isoform	—
PDB entities	4
Chains and sequence ranges	Author chain D； PDBConstruct 1–265； UniProt 1–265

DNA-DIRECTED RNA POLYMERASE

OrganismNot specified

UniProt B8YB57

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 13	DNA-DIRECTED RNA POLYMERASE × 1 （B8YB53） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB55） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB54） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB56） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB58） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB59） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB60） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB61） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB62） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB63） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB64） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB65） ZINC ION × 10 MAGNESIUM ION × 1 IRON/SULFUR CLUSTER × 1	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	B8YB57_SULSH
Isoform	—
PDB entities	5
Chains and sequence ranges	Author chain E； PDBConstruct 1–180； UniProt 1–180

DNA-DIRECTED RNA POLYMERASE

OrganismNot specified

UniProt B8YB58

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 13	DNA-DIRECTED RNA POLYMERASE × 1 （B8YB53） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB55） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB54） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB56） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB57） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB59） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB60） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB61） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB62） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB63） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB64） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB65） ZINC ION × 10 MAGNESIUM ION × 1 IRON/SULFUR CLUSTER × 1	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	B8YB58_SULSH
Isoform	—
PDB entities	6
Chains and sequence ranges	Author chain F； PDBConstruct 1–113； UniProt 1–113

DNA-DIRECTED RNA POLYMERASE

OrganismNot specified

UniProt B8YB59

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 13	DNA-DIRECTED RNA POLYMERASE × 1 （B8YB53） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB55） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB54） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB56） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB57） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB58） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB60） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB61） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB62） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB63） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB64） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB65） ZINC ION × 10 MAGNESIUM ION × 1 IRON/SULFUR CLUSTER × 1	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	B8YB59_SULSH
Isoform	—
PDB entities	7
Chains and sequence ranges	Author chain G； PDBConstruct 1–132； UniProt 1–132

DNA-DIRECTED RNA POLYMERASE

OrganismNot specified

UniProt B8YB60

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 13	DNA-DIRECTED RNA POLYMERASE × 1 （B8YB53） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB55） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB54） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB56） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB57） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB58） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB59） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB61） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB62） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB63） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB64） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB65） ZINC ION × 10 MAGNESIUM ION × 1 IRON/SULFUR CLUSTER × 1	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	B8YB60_SULSH
Isoform	—
PDB entities	8
Chains and sequence ranges	Author chain H； PDBConstruct 1–84； UniProt 1–84

DNA-DIRECTED RNA POLYMERASE

OrganismNot specified

UniProt B8YB61

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 13	DNA-DIRECTED RNA POLYMERASE × 1 （B8YB53） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB55） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB54） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB56） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB57） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB58） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB59） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB60） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB62） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB63） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB64） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB65） ZINC ION × 10 MAGNESIUM ION × 1 IRON/SULFUR CLUSTER × 1	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	B8YB61_SULSH
Isoform	—
PDB entities	9
Chains and sequence ranges	Author chain K； PDBConstruct 1–95； UniProt 1–95

DNA-DIRECTED RNA POLYMERASE

OrganismNot specified

UniProt B8YB62

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 13	DNA-DIRECTED RNA POLYMERASE × 1 （B8YB53） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB55） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB54） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB56） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB57） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB58） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB59） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB60） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB61） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB63） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB64） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB65） ZINC ION × 10 MAGNESIUM ION × 1 IRON/SULFUR CLUSTER × 1	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	B8YB62_SULSH
Isoform	—
PDB entities	10
Chains and sequence ranges	Author chain L； PDBConstruct 1–92； UniProt 1–92

DNA-DIRECTED RNA POLYMERASE

OrganismNot specified

UniProt B8YB63

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 13	DNA-DIRECTED RNA POLYMERASE × 1 （B8YB53） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB55） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB54） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB56） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB57） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB58） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB59） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB60） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB61） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB62） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB64） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB65） ZINC ION × 10 MAGNESIUM ION × 1 IRON/SULFUR CLUSTER × 1	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	B8YB63_SULSH
Isoform	—
PDB entities	11
Chains and sequence ranges	Author chain N； PDBConstruct 1–66； UniProt 1–66

DNA-DIRECTED RNA POLYMERASE

OrganismNot specified

UniProt B8YB64

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 13	DNA-DIRECTED RNA POLYMERASE × 1 （B8YB53） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB55） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB54） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB56） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB57） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB58） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB59） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB60） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB61） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB62） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB63） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB65） ZINC ION × 10 MAGNESIUM ION × 1 IRON/SULFUR CLUSTER × 1	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	B8YB64_SULSH
Isoform	—
PDB entities	12
Chains and sequence ranges	Author chain P； PDBConstruct 1–48； UniProt 1–48

DNA-DIRECTED RNA POLYMERASE

OrganismNot specified

UniProt B8YB65

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 13	DNA-DIRECTED RNA POLYMERASE × 1 （B8YB53） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB55） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB54） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB56） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB57） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB58） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB59） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB60） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB61） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB62） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB63） DNA-DIRECTED RNA POLYMERASE × 1 （B8YB64） ZINC ION × 10 MAGNESIUM ION × 1 IRON/SULFUR CLUSTER × 1	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	B8YB65_SULSH
Isoform	—
PDB entities	13
Chains and sequence ranges	Author chain Q； PDBConstruct 1–104； UniProt 1–104

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id	4ayb
Deposition date deposition_date	2012-06-19
Structure title title	RNAP at 3.2Ang
Keywords keywords	TRANSFERASE, MULTI-SUBUNIT, TRANSCRIPTION; TRANSFERASE
Experimental Method method	X-RAY DIFFRACTION

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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

4ayb__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

4ayb__assembly_1__model_1 | I(q)

100 plotted points; both axes use logarithmic scales.

4ayb__assembly_1__model_1 | P(r) · Pending

P(r) will be calculated and displayed separately for the same assembly/model.

Rg（Guinier）	49.22 Å
Rg (electron density)	48.81 Å
Total Rg	49.12 Å
Atom count	54890
Residues	3412
Excluded volume	487250 Å³
Maximum q	0.500 Å⁻¹

Assembly	Model	Structure unit	Oligomeric description	Status	CRYSOL	Actions
1	1	`4ayb__assembly_1__model_1`	tridecameric （13）	Success	4.1.3-1-20251215 (887e7ef)	View Download

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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (16)

Entity 1 Entity 1 polymer

Description description	DNA-DIRECTED RNA POLYMERASE
Molecular weight formula_weight	99766.5 kDa
EC 编号 ec_number	2.7.7.6
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	A
Atom count atom_count	54890

MSEKNIKGIKFGILSPDEIRKMSVTAIITPDVYDEDGTPIEGSVMDPRLGVIEPGQKCPTCGNTLGNCPGHFGHIELVRPVIHVGFVKHVYEFLKATCRRCGRVKISEDEIEKYSRIYNAIKKRWPSAARRLTEYVKKTAMKAQVCPHCGEKQFKIKLEKPYNFYEERKEGVAKLTPSDIRERLEKVPESDVEILGYDPTTSRPEWMILTVLPVPPITIRPSIMIESGIRAEDDLTHKLVDIVRINERLKESIDAGAPQLIIEDLWDLLQYHVATYFDNEIPGLPPSKHRSGRPLRTLAQRLKGKEGRFRGNLSGKRVDFSSRTVISPDPNISIDEVGVPEIIARTLTVPERITPWNIEKLRQFVINGPDKWPGANYVIRPDGRRIDLRYVKDRKELASTLAPGYVVERHLTDGDVVLFNRQPSLHRISMMAHRVRVLKGLTFRLNLLVCPPYNADFDGDEMNLHVPQSEEAIAEAKEIMLVHKNIITPRYGGPIIGAAQDYISGAYLLTVKTTLLTKEEAQQILGVADVKIDLGEPAILAPREYYTGKQVVSAFLPKDFNFHGQANVSSGPRLCKNEDCPHDSYVVIKNGILLEGVFDKKAIGNQQPESILHWLIKEYSDEYGKWLMDNLFRVFIRFVELQGFTMRLEDVSLGDDVKKEIYNEIDRAKVEVDNLIQKYKNGELEPIPGRTLEESLENYILDTLDKLRSTAGDIASKYLDPFNFAYVMARTGARGSVLNITQMAAMLGQQSVRGERIKRGYMTRTLPHFKPYDISPEARGFIYSSFRTGLKPTELFFHAAGGREGLVDTAVRTSQSGYMQRRLINALSDLRAEYDGTVRSLYGEVIQVAYGDDGVFPMYSAHGKTVDVNRIFERVVGWKT

Entity 2 Entity 2 polymer

Description description	DNA-DIRECTED RNA POLYMERASE
Molecular weight formula_weight	127582.0 kDa
EC 编号 ec_number	2.7.7.6
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	B

MNELSSNLSIDERWKVIEAYFKSKGLVRQHLDSYNDFVRNKLQEIIDEQGEIPTEIPGLKVRLGKIRIGKPRVRESDRGEREISPMEARLRNLTYAAPLWLTMIPVENNIEAEPEEVYIGDLPIMLKSAIDPISQYTLDKLIEIGEDPKDPGGYFIVNGSERVIVTQEDLAPNRVLVDTGKTGSNITHTAKIISSTAGYRVPVTIERLKDGTFHVSFPAVPGKIPFVILMRALGILTDRDIVYAVSLDPEIQNELFPSLEQASSIANVDDALDFIGSRVAIGQKRENRIEKAQQIIDKYFLPHLGTSADDRRKKAYYLAYAISKVIELYLGRREPDDKDHYANKRLRLAGDLFASLFRVAFKAFVKDLTYQLEKSKVRGRKLALKALVRPDIVTERIRHALATGNWVGGRTGVSQLLDRTNWLSMLSHLRRVISSLARGQPNFEARDLHGTQWGRMCPFETPEGPNSGLVKNLALMAQIAVGINEKIVEKTLYEMGVVPVEEVIRRVTEGGEDQNEYLKWSKVILNGRLVGYYRDGEELAKKIRERRRKGEISDEVNVGHIVTDFINEVHVNCDSGRVRRPLIIVSNGNPLVTREDIEKLDSGSITFDDLVRQGKIEYLDAEEEENAYVALEPSDLTPEHTHLEIWSPAILGITASIIPYPEHNQSPRNTYQSAMAKQALGLYAANYQLRTDTRAHLLHYPQRPLVQTRALDIIGYTNRPAGNNAILAVISFTGYNMEDSIIMNRSSVERGMYRSTFFRLYSTEEVKYPGGQEDKIVMPEPGVRGYKGKEYYRLLEDNGVVSPEVEVKGGDVLIGKVSPPRFLQEFKELSPEQAKRDTSIVTRHGEMGIVDLVLITETAEGNKLVKVRVRDLRIPSIGDKFASRHGQKGVIGMLIPQVDMPYTVKGVVPDVILNPHALPSRMTLGQIMEGIAGKYAALSGNIVDATPFYKTPIEQLQNEILKYGYLPDATEVTYDGRTGQKIKSRIYFGVVYYQKLHHMVADKIHARARGPVQILTRQPTEGRAREGGLRFGEMERDCLIGFGTAMLLKDRLLDNSDRTTIYVCDQCGYIGWYDKNKNKYVCPIHGDKSNLFPVTVSYAFKLLIQELMSMIISPRLILEDRVGLSGGKGNE

Entity 3 Entity 3 polymer

Description description	DNA-DIRECTED RNA POLYMERASE
Molecular weight formula_weight	43792.8 kDa
EC 编号 ec_number	2.7.7.6
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	C

MENVIDEKDKSYLEEKVKQASNILPQKIVEDLKNLISNKEVLVTRDEIDKIFDLAIKEYSEGLIAPGEAIGIVAAQSVGEPGTQMTLRTFHFAGIRELNVTLGLPRLIEIVDAKKVPSTPMMTIYLTDEYKHDKEKALEVARKLEYTKIENVVSSTSIDIASMSIILQLDNEMLKDKGVTVDDVKKAINRLKLGEFVIDESEGNTLNISFANIDSIAALFKLRDKILNTKIKGIKGIKRAIVQKKGDEYIILTDGSNLSGVLSVKGVDIAKVETNNIREIEEVFGIEAAREIIIREISKVLAEQGLDVDMRHILLVADVMTRTGVVRQIGRHGVTGEKNSVLARAAFEVTVKHLLDAAARGDVEEFKGVVENIIIGHPIKLGTGMVELTMRPILR

Entity 4 Entity 4 polymer

Description description	DNA-DIRECTED RNA POLYMERASE
Molecular weight formula_weight	30179.1 kDa
EC 编号 ec_number	2.7.7.6
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	D

MSINLLHKDDKRIDLVFEGYPLEFVNAIRRAAMLYVPVMSIDDVYFIENNSPLYDEILAHRLALIPFTSEEALDTYRWPEECIDCTENCEKCYTKIYIEAEALNEPKMLYSKDIKSEDPSIVPISGDIPIVLLGANQKISLEARLRLGYGKEHAKFIPVSLAIVRYYPKVEILGNCEKGATVCPEGVFELKDGKLSVKNELACTLCEECLRYCNGLIRISSVEDKYILELESVGSLKPERILLEAGKSIIRKIEELEKKLVEVIK

Entity 5 Entity 5 polymer

Description description	DNA-DIRECTED RNA POLYMERASE
Molecular weight formula_weight	20328.7 kDa
EC 编号 ec_number	2.7.7.6
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	E

MYKLIKARSIVRIPPNEFGKPLNEIALNELRQQYQEKILKDLGLVLAILNVKTSEEGMLVFGDGATYHEVEFDMITYVPVVQEVVEGEVLQVDNYGVFVNLGPMDGLVHISQITDDTLKYDNVRGIIFGEKSKKVIQKGDKVRARVISVASTVTGRLPRIALTMRQPYLGKLEWITQAKK

Entity 6 Entity 6 polymer

Description description	DNA-DIRECTED RNA POLYMERASE
Molecular weight formula_weight	12822.6 kDa
EC 编号 ec_number	2.7.7.6
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	F

MSSVYIVEEHYIPYSVAKKLLSDVIKSGSSSNLLQRTYDYLNSVEKCDAESAQKVVEELSSIISREDVRAVLASICPITPDEVRSILIMDSNRTYTSEDIQKIIDIIRKYIKS

Entity 7 Entity 7 polymer

Description description	DNA-DIRECTED RNA POLYMERASE
Molecular weight formula_weight	15139.5 kDa
EC 编号 ec_number	2.7.7.6
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	G

MMESKAQEIILSCEINSIERGSLKNLSIIHMSCNDFNISFDIIDSINIFSQKEKVKAFISKNRLSYTNDDFCGHGYIVTELKDSSSNNGNRYITIISLFGLLVKIISNKESFLKIHQLNVMDHIYFCVKKNT

Entity 8 Entity 8 polymer

Description description	DNA-DIRECTED RNA POLYMERASE
Molecular weight formula_weight	9688.3 kDa
EC 编号 ec_number	2.7.7.6
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	H

MRGSSNRKIDPRIHYLVPKHEVLSIDEAYKILKELGIRPEQLPWIRASDPVARSINAKPGDIIRIIRKSQLYGEVVSYRYVISG

Entity 9 Entity 9 polymer

Description description	DNA-DIRECTED RNA POLYMERASE
Molecular weight formula_weight	10729.5 kDa
EC 编号 ec_number	2.7.7.6
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	K

MGLERDGILSQDLHFNEVFVSLWQNKLTRYEIARVISARALQLAMGAPALIDINNISSTDVISIAEEEFKRGVLPITIRRRLPNGKIILLSLRKS

Entity 10 Entity 10 polymer

Description description	DNA-DIRECTED RNA POLYMERASE
Molecular weight formula_weight	10211.8 kDa
EC 编号 ec_number	2.7.7.6
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	L

MEIKILKSESNYLELEIEGEDHTLGNLIAGTLRKISGVSFASYYQPHPLTDKIIVKILTDGSIAPKDALLKAIETVRVMASHYIDEIKGLTK

Entity 11 Entity 11 polymer

Description description	DNA-DIRECTED RNA POLYMERASE
Molecular weight formula_weight	7617.1 kDa
EC 编号 ec_number	2.7.7.6
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	N

MMIPIRCFTCGSLIADKWQPFITRVNAGENPGKVLDDLGVKRYCCRRMLLSHIDIISEVIHYTRPI

Entity 12 Entity 12 polymer

Description description	DNA-DIRECTED RNA POLYMERASE
Molecular weight formula_weight	5607.0 kDa
EC 编号 ec_number	2.7.7.6
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	P

MAVYRCGKCWKTFTDEQLKVLPGVRCPYCGYKIIFMVRKPTIKIVKAI

Entity 13 Entity 13 polymer

Description description	DNA-DIRECTED RNA POLYMERASE
Molecular weight formula_weight	12170.6 kDa
EC 编号 ec_number	2.7.7.6
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	Q

MVSGMSTEEEKEGTNDEEVSEEREVEETSEEEFPKLSIQDIELLMKNTEIWDNLLNGKISVDEAKRLFEDNYKDYEKRDSRRKAKKAASKKVKKTKKKEKSVEG

Entity 14 Entity 14 non-polymer

Description description	ZINC ION
Molecular weight formula_weight	65.4 kDa
Source method src_method	syn
Copy count entity_count	10

Entity 15 Entity 15 non-polymer

Description description	MAGNESIUM ION
Molecular weight formula_weight	24.3 kDa
Source method src_method	syn
Copy count entity_count	1

Entity 16 Entity 16 non-polymer

Description description	IRON/SULFUR CLUSTER
Molecular weight formula_weight	351.6 kDa
Source method src_method	syn
Copy count entity_count	1

▼

6. Fold Classification (SCOP + CATH) 28 domains

CATH v4.4 (28 domains)

Domain ID domain_id	4aybA02
Class class	2 — Mainly Beta
Architecture architecture	40 — Beta Barrel
Topology topology	40 — Barwin-like endoglucanases
Homologous superfamily homologous superfamily	20 —

Domain ID domain_id	4aybA03
Class class	3 — Alpha Beta
Architecture architecture	30 — 2-Layer Sandwich
Topology topology	1490 — Dna Ligase; domain 1
Homologous superfamily homologous superfamily	180 — RNA polymerase ii

Domain ID domain_id	4aybA04
Class class	1 — Mainly Alpha
Architecture architecture	10 — Orthogonal Bundle
Topology topology	10 — Arc Repressor Mutant, subunit A
Homologous superfamily homologous superfamily	1950 —

Domain ID domain_id	4aybA05
Class class	4 — Few Secondary Structures
Architecture architecture	10 — Irregular
Topology topology	320 — Dihydrolipoamide Transferase
Homologous superfamily homologous superfamily	40 —

Domain ID domain_id	4aybA06
Class class	2 — Mainly Beta
Architecture architecture	60 — Sandwich
Topology topology	40 — Immunoglobulin-like
Homologous superfamily homologous superfamily	2940 —

Domain ID domain_id	4aybA07
Class class	1 — Mainly Alpha
Architecture architecture	10 — Orthogonal Bundle
Topology topology	132 — Topoisomerase I; Chain A, domain 4
Homologous superfamily homologous superfamily	30 — RNA polymerase Rpb1 funnel domain

Domain ID domain_id	4aybA08
Class class	6 — Special
Architecture architecture	10 — Helix non-globular
Topology topology	250 — Single alpha-helices involved in coiled-coils or other helix-helix interfaces
Homologous superfamily homologous superfamily	2940 —

Domain ID domain_id	4aybA09
Class class	6 — Special
Architecture architecture	20 — Other non-globular
Topology topology	50 — N-terminal domain of TfIIb
Homologous superfamily homologous superfamily	80 —

Domain ID domain_id	4aybB04
Class class	3 — Alpha Beta
Architecture architecture	90 — Alpha-Beta Complex
Topology topology	1110 — Dna-directed Rna Polymerase Ii 140kd Polypeptide; Chain: B; domain 3
Homologous superfamily homologous superfamily	10 — RNA polymerase Rpb2, domain 2

Domain ID domain_id	4aybB05
Class class	3 — Alpha Beta
Architecture architecture	90 — Alpha-Beta Complex
Topology topology	1070 — Hypothetical Protein Ta0175; Chain: A, domain 2
Homologous superfamily homologous superfamily	20 —

Domain ID domain_id	4aybB06
Class class	2 — Mainly Beta
Architecture architecture	40 — Beta Barrel
Topology topology	270 — Dna-directed Rna Polymerase Ii 140kd Polypeptide; Chain: B; Domain 6
Homologous superfamily homologous superfamily	10 — DNA-directed RNA polymerase, subunit 2, domain 6

Domain ID domain_id	4aybB07
Class class	2 — Mainly Beta
Architecture architecture	40 — Beta Barrel
Topology topology	50 — OB fold (Dihydrolipoamide Acetyltransferase, E2P)
Homologous superfamily homologous superfamily	150 — RNA polymerase II, Rpb2 subunit, wall domain

Domain ID domain_id	4aybB08
Class class	3 — Alpha Beta
Architecture architecture	90 — Alpha-Beta Complex
Topology topology	1800 — DCoH-like
Homologous superfamily homologous superfamily	10 — RNA polymerase alpha subunit dimerisation domain

Domain ID domain_id	4aybC02
Class class	1 — Mainly Alpha
Architecture architecture	10 — Orthogonal Bundle
Topology topology	150 — DNA polymerase; domain 1
Homologous superfamily homologous superfamily	390 —

Domain ID domain_id	4aybD01
Class class	3 — Alpha Beta
Architecture architecture	30 — 2-Layer Sandwich
Topology topology	1360 — Gyrase A; domain 2
Homologous superfamily homologous superfamily	10 — RNA polymerase, RBP11-like subunit

Domain ID domain_id	4aybD02
Class class	2 — Mainly Beta
Architecture architecture	170 — Beta Complex
Topology topology	120 — RNA Polymerase Alpha Subunit; Chain A, domain 2
Homologous superfamily homologous superfamily	12 — DNA-directed RNA polymerase, insert domain

Domain ID domain_id	4aybD03
Class class	3 — Alpha Beta
Architecture architecture	30 — 2-Layer Sandwich
Topology topology	70 — Alpha-Beta Plaits
Homologous superfamily homologous superfamily	20 —

Domain ID domain_id	4aybE01
Class class	3 — Alpha Beta
Architecture architecture	30 — 2-Layer Sandwich
Topology topology	1490 — Dna Ligase; domain 1
Homologous superfamily homologous superfamily	120 — RNA polymerase Rpb7-like, N-terminal domain

Domain ID domain_id	4aybE02
Class class	2 — Mainly Beta
Architecture architecture	40 — Beta Barrel
Topology topology	50 — OB fold (Dihydrolipoamide Acetyltransferase, E2P)
Homologous superfamily homologous superfamily	140 — Nucleic acid-binding proteins

Domain ID domain_id	4aybF01
Class class	6 — Special
Architecture architecture	10 — Helix non-globular
Topology topology	140 — Helix Hairpins
Homologous superfamily homologous superfamily	930 —

Domain ID domain_id	4aybF02
Class class	1 — Mainly Alpha
Architecture architecture	10 — Orthogonal Bundle
Topology topology	150 — DNA polymerase; domain 1
Homologous superfamily homologous superfamily	80 — HRDC domain

Domain ID domain_id	4aybG00
Class class	2 — Mainly Beta
Architecture architecture	40 — Beta Barrel
Topology topology	50 — OB fold (Dihydrolipoamide Acetyltransferase, E2P)
Homologous superfamily homologous superfamily	140 — Nucleic acid-binding proteins

Domain ID domain_id	4aybH00
Class class	3 — Alpha Beta
Architecture architecture	90 — Alpha-Beta Complex
Topology topology	940 — Eukaryotic RPB6 RNA polymerase subunit
Homologous superfamily homologous superfamily	20 — RPB5-like RNA polymerase subunit

Domain ID domain_id	4aybK00
Class class	3 — Alpha Beta
Architecture architecture	90 — Alpha-Beta Complex
Topology topology	940 — Eukaryotic RPB6 RNA polymerase subunit
Homologous superfamily homologous superfamily	10 — RNA polymerase subunit, RPB6/omega

Domain ID domain_id	4aybL00
Class class	3 — Alpha Beta
Architecture architecture	30 — 2-Layer Sandwich
Topology topology	1360 — Gyrase A; domain 2
Homologous superfamily homologous superfamily	10 — RNA polymerase, RBP11-like subunit

Domain ID domain_id	4aybN00
Class class	1 — Mainly Alpha
Architecture architecture	10 — Orthogonal Bundle
Topology topology	10 — Arc Repressor Mutant, subunit A
Homologous superfamily homologous superfamily	60 — Homeodomain-like

Domain ID domain_id	4aybP00
Class class	2 — Mainly Beta
Architecture architecture	20 — Single Sheet
Topology topology	28 — Rubrerythrin, domain 2
Homologous superfamily homologous superfamily	30 — RNA polymerase ii, chain L

Domain ID domain_id	4aybQ00
Class class	6 — Special
Architecture architecture	20 — Other non-globular
Topology topology	450 — DNA Excision Repair, Uvrb; Chain A
Homologous superfamily homologous superfamily	10 —

▶

Unit-cell length a length_a	195.725 Å
Unit-cell length b length_b	212.415 Å
Unit-cell length c length_c	128.757 Å
Unit-cell angle α angle_alpha	90.00 °
Unit-cell angle β angle_beta	90.00 °
Unit-cell angle γ angle_gamma	90.00 °
Molecules per unit cell Z z_pdb	4

Space group space_group	P 21 21 2
Space-group number int_tables_number	18
Crystal system crystal_system	—

Resolution resolution	3.202 Å
Low-resolution limit resolution_low	40.097 Å
R factor r_factor	0.2454
R_work r_work	0.2425
R_free r_free	0.3005

RNAP at 3.2Ang

1. Protein Identity and Related Structures Protein Identity & Related Structures

DNA-DIRECTED RNA POLYMERASE

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

DNA-DIRECTED RNA POLYMERASE

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

DNA-DIRECTED RNA POLYMERASE

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

DNA-DIRECTED RNA POLYMERASE

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

DNA-DIRECTED RNA POLYMERASE

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

DNA-DIRECTED RNA POLYMERASE

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

DNA-DIRECTED RNA POLYMERASE

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

DNA-DIRECTED RNA POLYMERASE

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

DNA-DIRECTED RNA POLYMERASE

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

DNA-DIRECTED RNA POLYMERASE

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer