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4hkj

Structure of Cowpox CPXV203 in complex with MHCI (H-2Kb)

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

H-2 class I histocompatibility antigen, K-B alpha chain

Mus musculus

UniProt P01901

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 4 Beta-2-microglobulin × 1 （P61769） Ovalbumin × 1 （P01012） CPXV203 protein × 1 （Q8QMP2） water × 4 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 4 Beta-2-microglobulin × 1 （P61769） Ovalbumin × 1 （P01012） CPXV203 protein × 1 （Q8QMP2） water × 3 Consistent with protein count
3 Protein heterocomplex Heteromer Protein 4 Beta-2-microglobulin × 1 （P61769） Ovalbumin × 1 （P01012） CPXV203 protein × 1 （Q8QMP2） water × 4 Consistent with protein count
4 Protein heterocomplex Heteromer Protein 4 Beta-2-microglobulin × 1 （P61769） Ovalbumin × 1 （P01012） CPXV203 protein × 1 （Q8QMP2） water × 3 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1bqh 1bqh 1fo0 1fzj 1fzj 1fzk 1fzk 1fzm 1fzo 1g6r 1g6r 1g7p

141 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name HA1B_MOUSE
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–280； UniProt 22–301 Author chain E； PDBConstruct 1–280； UniProt 22–301 Author chain I； PDBConstruct 1–280； UniProt 22–301 Author chain M； PDBConstruct 1–280； UniProt 22–301

Beta-2-microglobulin

Homo sapiens

UniProt P61769

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 4 H-2 class I histocompatibility antigen, K-B alpha chain × 1 （P01901） Ovalbumin × 1 （P01012） CPXV203 protein × 1 （Q8QMP2） water × 4 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 4 H-2 class I histocompatibility antigen, K-B alpha chain × 1 （P01901） Ovalbumin × 1 （P01012） CPXV203 protein × 1 （Q8QMP2） water × 3 Consistent with protein count
3 Protein heterocomplex Heteromer Protein 4 H-2 class I histocompatibility antigen, K-B alpha chain × 1 （P01901） Ovalbumin × 1 （P01012） CPXV203 protein × 1 （Q8QMP2） water × 4 Consistent with protein count
4 Protein heterocomplex Heteromer Protein 4 H-2 class I histocompatibility antigen, K-B alpha chain × 1 （P01901） Ovalbumin × 1 （P01012） CPXV203 protein × 1 （Q8QMP2） water × 3 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1jnj 1lds 1py4 1py4 1py4 1py4 2d4d 2d4f 2vb5 2xks 2xku 2yxf

61 assemblies; showing the first 12

Homodimer
2x89 2x89 2z9t 3low 4r9h 4r9h 4ra3 4ra3 4rah 6m1b

10 assemblies

Homotetramer
2e8d 2f8o 3tlr 3tm6 3tm6 7afv

6 assemblies

Other homooligomers
3ciq 3ciq 3loz 6gk3 8a7o 8a7p 8a7q 8a7t

8 assemblies

Heteromeric or nucleic-acid complex
1a1m 1a1n 1a1o 1a6z 1a6z 1a9b 1a9b 1a9e 1agb 1agc 1agd 1age

1914 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name B2MG_HUMAN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain B； PDBConstruct 2–100； UniProt 21–119 Author chain F； PDBConstruct 2–100； UniProt 21–119 Author chain J； PDBConstruct 2–100； UniProt 21–119 Author chain N； PDBConstruct 2–100； UniProt 21–119

Ovalbumin

OrganismNot specified

UniProt P01012

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 4 H-2 class I histocompatibility antigen, K-B alpha chain × 1 （P01901） Beta-2-microglobulin × 1 （P61769） CPXV203 protein × 1 （Q8QMP2） water × 4 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 4 H-2 class I histocompatibility antigen, K-B alpha chain × 1 （P01901） Beta-2-microglobulin × 1 （P61769） CPXV203 protein × 1 （Q8QMP2） water × 3 Consistent with protein count
3 Protein heterocomplex Heteromer Protein 4 H-2 class I histocompatibility antigen, K-B alpha chain × 1 （P01901） Beta-2-microglobulin × 1 （P61769） CPXV203 protein × 1 （Q8QMP2） water × 4 Consistent with protein count
4 Protein heterocomplex Heteromer Protein 4 H-2 class I histocompatibility antigen, K-B alpha chain × 1 （P01901） Beta-2-microglobulin × 1 （P61769） CPXV203 protein × 1 （Q8QMP2） water × 3 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1jti 1jti 1uhg

3 assemblies

Homodimer
1ova 1ova

2 assemblies

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1p1z 1p4l 1uhg 1uhg 1uhg 1vac 3cvh 3cvh 3p9l 3p9l 3p9m 3p9m

18 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name OVAL_CHICK
Isoform —
PDB entities 3
Chains and sequence ranges Author chain C； PDBConstruct 1–8； UniProt 258–265 Author chain G； PDBConstruct 1–8； UniProt 258–265 Author chain K； PDBConstruct 1–8； UniProt 258–265 Author chain O； PDBConstruct 1–8； UniProt 258–265

CPXV203 protein

Cowpox virus

UniProt Q8QMP2

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 4 H-2 class I histocompatibility antigen, K-B alpha chain × 1 （P01901） Beta-2-microglobulin × 1 （P61769） Ovalbumin × 1 （P01012） water × 4 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 4 H-2 class I histocompatibility antigen, K-B alpha chain × 1 （P01901） Beta-2-microglobulin × 1 （P61769） Ovalbumin × 1 （P01012） water × 3 Consistent with protein count
3 Protein heterocomplex Heteromer Protein 4 H-2 class I histocompatibility antigen, K-B alpha chain × 1 （P01901） Beta-2-microglobulin × 1 （P61769） Ovalbumin × 1 （P01012） water × 4 Consistent with protein count
4 Protein heterocomplex Heteromer Protein 4 H-2 class I histocompatibility antigen, K-B alpha chain × 1 （P01901） Beta-2-microglobulin × 1 （P61769） Ovalbumin × 1 （P01012） water × 3 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
4hkj 4hkj 4hkj 4hkj

4 assemblies

View Construct and Data Evidence
UniProt name Q8QMP2_COWPX
Isoform —
PDB entities 4
Chains and sequence ranges Author chain D； PDBConstruct 2–206； UniProt 17–221 Author chain H； PDBConstruct 2–206； UniProt 17–221 Author chain L； PDBConstruct 2–206； UniProt 17–221 Author chain P； PDBConstruct 2–206； UniProt 17–221

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id4hkj
Deposition date deposition_date2012-10-15
Structure title titleStructure of Cowpox CPXV203 in complex with MHCI (H-2Kb)
Keywords keywords;viral immune evasion proteins, antigen presentation, structural genomics, NIAID, National Institute of Allergy and Infectious Diseases, Center for Structural Genomics of Infectious Diseases, CSGID, inhibitor, intracellular, IMMUNE SYSTEM-VIRAL PROTEIN complex ;; IMMUNE SYSTEM/VIRAL PROTEIN
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

4hkj__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

4hkj__assembly_1__model_1 | I(q)

10-2 10-1 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

4hkj__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）26.01 Å
Rg (electron density)24.80 Å
Total Rg25.72 Å
Atom count4647
Residues568
Excluded volume81848 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 4hkj__assembly_1__model_1 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 4hkj__assembly_2__model_1 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
3 1 4hkj__assembly_3__model_1 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
4 1 4hkj__assembly_4__model_1 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (5)

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6. Fold Classification (SCOP + CATH) 16 domains

CATH v4.4 (16 domains)

Domain ID domain_id4hkjA01
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology500 — Murine Class I Major Histocompatibility Complex, H2-DB; Chain A, domain 1
Homologous superfamily homologous superfamily10 — MHC class I-like antigen recognition-like
Domain ID domain_id4hkjA02
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology40 — Immunoglobulin-like
Homologous superfamily homologous superfamily10 — Immunoglobulins
Domain ID domain_id4hkjB00
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology40 — Immunoglobulin-like
Homologous superfamily homologous superfamily10 — Immunoglobulins
Domain ID domain_id4hkjD00
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology240 — Viral Chemokine Inhibitor; Chain A
Homologous superfamily homologous superfamily30 —
Domain ID domain_id4hkjE01
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology500 — Murine Class I Major Histocompatibility Complex, H2-DB; Chain A, domain 1
Homologous superfamily homologous superfamily10 — MHC class I-like antigen recognition-like
Domain ID domain_id4hkjE02
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology40 — Immunoglobulin-like
Homologous superfamily homologous superfamily10 — Immunoglobulins
Domain ID domain_id4hkjF00
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology40 — Immunoglobulin-like
Homologous superfamily homologous superfamily10 — Immunoglobulins
Domain ID domain_id4hkjH00
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology240 — Viral Chemokine Inhibitor; Chain A
Homologous superfamily homologous superfamily30 —
Domain ID domain_id4hkjI01
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology500 — Murine Class I Major Histocompatibility Complex, H2-DB; Chain A, domain 1
Homologous superfamily homologous superfamily10 — MHC class I-like antigen recognition-like
Domain ID domain_id4hkjI02
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology40 — Immunoglobulin-like
Homologous superfamily homologous superfamily10 — Immunoglobulins
Domain ID domain_id4hkjJ00
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology40 — Immunoglobulin-like
Homologous superfamily homologous superfamily10 — Immunoglobulins
Domain ID domain_id4hkjL00
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology240 — Viral Chemokine Inhibitor; Chain A
Homologous superfamily homologous superfamily30 —
Domain ID domain_id4hkjM01
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology500 — Murine Class I Major Histocompatibility Complex, H2-DB; Chain A, domain 1
Homologous superfamily homologous superfamily10 — MHC class I-like antigen recognition-like
Domain ID domain_id4hkjM02
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology40 — Immunoglobulin-like
Homologous superfamily homologous superfamily10 — Immunoglobulins
Domain ID domain_id4hkjN00
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology40 — Immunoglobulin-like
Homologous superfamily homologous superfamily10 — Immunoglobulins
Domain ID domain_id4hkjP00
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology240 — Viral Chemokine Inhibitor; Chain A
Homologous superfamily homologous superfamily30 —
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7. Citations (1)