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4l75

Ca2+-bound D184N mutant MthK RCK domain at 2.4 Angstrom

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Calcium-gated potassium channel MthK

Methanothermobacter thermautotrophicus

UniProt O27564

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein homooligomer Homooligomer Protein 2 CALCIUM ION × 2 water × 2 Consistent with protein count
2 Protein homooligomer Homooligomer Protein 2 CALCIUM ION × 2 water × 2 Consistent with protein count
3 Protein homooligomer Homooligomer Protein 2 CALCIUM ION × 2 water × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
4ei2 4ei2 4ei2 4ei2 4ei2 4ei2 4ei2 4ei2 4ei2 4ei2 4ei2 4ei2

16 assemblies; showing the first 12

Homodimer
2aef 2aej 2aem 2ogu 3kxd 3rbx 3rbx 3rbx 4l73 4l74 4l75 4l75

16 assemblies; showing the first 12

Homotetramer
3ldc 3ldd 3lde 3ous 3r65 4hyo 4hyo 4hz3 4hz3 4qe7 4qe9 6u9p

15 assemblies; showing the first 12

Other homooligomers
1lnq 2fy8 2fy8 2ogu 3rbz 4ro0 4ro0 4ro0 4ro0 4ro0 5bki 5bkj

30 assemblies; showing the first 12

Heteromeric or nucleic-acid complex

None

View Construct and Data Evidence
UniProt name MTHK_METTH
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–230； UniProt 107–336 Author chain B； PDBConstruct 1–230； UniProt 107–336 Author chain C； PDBConstruct 1–230； UniProt 107–336 Author chain D； PDBConstruct 1–230； UniProt 107–336 Author chain E； PDBConstruct 1–230； UniProt 107–336 Author chain F； PDBConstruct 1–230； UniProt 107–336

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id4l75
Deposition date deposition_date2013-06-13
Structure title titleCa2+-bound D184N mutant MthK RCK domain at 2.4 Angstrom
Keywords keywordsRossmann Fold, regulatory domain, calcium binding, membrane-associated, METAL TRANSPORT; METAL TRANSPORT
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

4l75__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

4l75__assembly_1__model_1 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

4l75__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）24.26 Å
Rg (electron density)23.22 Å
Total Rg23.99 Å
Atom count3497
Residues453
Excluded volume62188 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 4l75__assembly_1__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 4l75__assembly_2__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
3 1 4l75__assembly_3__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (3)

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6. Fold Classification (SCOP + CATH) 34 domains

SCOP 2.08 (16 domains)

Domain ID domain_idd4l75a1
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.2 — NAD(P)-binding Rossmann-fold domains
Superfamily Superfamily superfamilyc.2.1 — NAD(P)-binding Rossmann-fold domains
Family Family familyc.2.1.9 — Potassium channel NAD-binding domain
Domain ID domain_idd4l75a2
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.286 — TrkA C-terminal domain-like
Superfamily Superfamily superfamilyd.286.1 — TrkA C-terminal domain-like
Family Family familyd.286.1.0 — automated matches
Domain ID domain_idd4l75a3
Class classl — Artifacts
Fold Fold foldl.1 — Tags
Superfamily Superfamily superfamilyl.1.1 — Tags
Family Family familyl.1.1.1 — Tags
Domain ID domain_idd4l75b1
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.2 — NAD(P)-binding Rossmann-fold domains
Superfamily Superfamily superfamilyc.2.1 — NAD(P)-binding Rossmann-fold domains
Family Family familyc.2.1.9 — Potassium channel NAD-binding domain
Domain ID domain_idd4l75b2
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.286 — TrkA C-terminal domain-like
Superfamily Superfamily superfamilyd.286.1 — TrkA C-terminal domain-like
Family Family familyd.286.1.0 — automated matches
Domain ID domain_idd4l75b3
Class classl — Artifacts
Fold Fold foldl.1 — Tags
Superfamily Superfamily superfamilyl.1.1 — Tags
Family Family familyl.1.1.1 — Tags
Domain ID domain_idd4l75c1
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.2 — NAD(P)-binding Rossmann-fold domains
Superfamily Superfamily superfamilyc.2.1 — NAD(P)-binding Rossmann-fold domains
Family Family familyc.2.1.9 — Potassium channel NAD-binding domain
Domain ID domain_idd4l75c2
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.286 — TrkA C-terminal domain-like
Superfamily Superfamily superfamilyd.286.1 — TrkA C-terminal domain-like
Family Family familyd.286.1.0 — automated matches
Domain ID domain_idd4l75d1
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.2 — NAD(P)-binding Rossmann-fold domains
Superfamily Superfamily superfamilyc.2.1 — NAD(P)-binding Rossmann-fold domains
Family Family familyc.2.1.9 — Potassium channel NAD-binding domain
Domain ID domain_idd4l75d2
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.286 — TrkA C-terminal domain-like
Superfamily Superfamily superfamilyd.286.1 — TrkA C-terminal domain-like
Family Family familyd.286.1.0 — automated matches
Domain ID domain_idd4l75d3
Class classl — Artifacts
Fold Fold foldl.1 — Tags
Superfamily Superfamily superfamilyl.1.1 — Tags
Family Family familyl.1.1.1 — Tags
Domain ID domain_idd4l75e1
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.2 — NAD(P)-binding Rossmann-fold domains
Superfamily Superfamily superfamilyc.2.1 — NAD(P)-binding Rossmann-fold domains
Family Family familyc.2.1.9 — Potassium channel NAD-binding domain
Domain ID domain_idd4l75e2
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.286 — TrkA C-terminal domain-like
Superfamily Superfamily superfamilyd.286.1 — TrkA C-terminal domain-like
Family Family familyd.286.1.0 — automated matches
Domain ID domain_idd4l75f1
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.2 — NAD(P)-binding Rossmann-fold domains
Superfamily Superfamily superfamilyc.2.1 — NAD(P)-binding Rossmann-fold domains
Family Family familyc.2.1.9 — Potassium channel NAD-binding domain
Domain ID domain_idd4l75f2
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.286 — TrkA C-terminal domain-like
Superfamily Superfamily superfamilyd.286.1 — TrkA C-terminal domain-like
Family Family familyd.286.1.0 — automated matches
Domain ID domain_idd4l75f3
Class classl — Artifacts
Fold Fold foldl.1 — Tags
Superfamily Superfamily superfamilyl.1.1 — Tags
Family Family familyl.1.1.1 — Tags

CATH v4.4 (18 domains)

Domain ID domain_id4l75A01
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily720 — NAD(P)-binding Rossmann-like Domain
Domain ID domain_id4l75A02
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology5 — Single alpha-helices involved in coiled-coils or other helix-helix interfaces
Homologous superfamily homologous superfamily870 — Voltage-gated potassium channel
Domain ID domain_id4l75A03
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology70 — Alpha-Beta Plaits
Homologous superfamily homologous superfamily1450 — Regulator of K+ conductance, C-terminal domain
Domain ID domain_id4l75B01
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily720 — NAD(P)-binding Rossmann-like Domain
Domain ID domain_id4l75B02
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology5 — Single alpha-helices involved in coiled-coils or other helix-helix interfaces
Homologous superfamily homologous superfamily870 — Voltage-gated potassium channel
Domain ID domain_id4l75B03
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology70 — Alpha-Beta Plaits
Homologous superfamily homologous superfamily1450 — Regulator of K+ conductance, C-terminal domain
Domain ID domain_id4l75C01
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily720 — NAD(P)-binding Rossmann-like Domain
Domain ID domain_id4l75C02
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology5 — Single alpha-helices involved in coiled-coils or other helix-helix interfaces
Homologous superfamily homologous superfamily870 — Voltage-gated potassium channel
Domain ID domain_id4l75C03
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology70 — Alpha-Beta Plaits
Homologous superfamily homologous superfamily1450 — Regulator of K+ conductance, C-terminal domain
Domain ID domain_id4l75D01
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily720 — NAD(P)-binding Rossmann-like Domain
Domain ID domain_id4l75D02
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology5 — Single alpha-helices involved in coiled-coils or other helix-helix interfaces
Homologous superfamily homologous superfamily870 — Voltage-gated potassium channel
Domain ID domain_id4l75D03
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology70 — Alpha-Beta Plaits
Homologous superfamily homologous superfamily1450 — Regulator of K+ conductance, C-terminal domain
Domain ID domain_id4l75E01
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily720 — NAD(P)-binding Rossmann-like Domain
Domain ID domain_id4l75E02
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology5 — Single alpha-helices involved in coiled-coils or other helix-helix interfaces
Homologous superfamily homologous superfamily870 — Voltage-gated potassium channel
Domain ID domain_id4l75E03
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology70 — Alpha-Beta Plaits
Homologous superfamily homologous superfamily1450 — Regulator of K+ conductance, C-terminal domain
Domain ID domain_id4l75F01
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily720 — NAD(P)-binding Rossmann-like Domain
Domain ID domain_id4l75F02
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology5 — Single alpha-helices involved in coiled-coils or other helix-helix interfaces
Homologous superfamily homologous superfamily870 — Voltage-gated potassium channel
Domain ID domain_id4l75F03
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology70 — Alpha-Beta Plaits
Homologous superfamily homologous superfamily1450 — Regulator of K+ conductance, C-terminal domain
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7. Citations (1)