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4pkh

Complex of ADP-actin With the N-terminal Actin-Binding Domain of Tropomodulin

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Actin, alpha skeletal muscle

OrganismNot specified

UniProt P68135

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Insufficient information Heteromer Protein 2 Gelsolin,Tropomodulin-1 chimera × 1 （P06396,P28289） ADENOSINE-5'-DIPHOSPHATE × 1 CALCIUM ION × 3 water × 2 Consistent with protein count
2 Insufficient information Heteromer Protein 2 Gelsolin,Tropomodulin-1 chimera × 1 （P06396,P28289） ADENOSINE-5'-DIPHOSPHATE × 1 CALCIUM ION × 3 water × 2 Consistent with protein count
3 Insufficient information Heteromer Protein 2 Gelsolin,Tropomodulin-1 chimera × 1 （P06396,P28289） ADENOSINE-5'-DIPHOSPHATE × 1 CALCIUM ION × 3 water × 2 Consistent with protein count
4 Insufficient information Heteromer Protein 2 Gelsolin,Tropomodulin-1 chimera × 1 （P06396,P28289） ADENOSINE-5'-DIPHOSPHATE × 1 CALCIUM ION × 3 water × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1ijj 1ijj 1j6z 1nwk 1qz5 1s22 1wua 2asm 2aso 2asp 2fxu 2gwj

40 assemblies; showing the first 12

Homodimer
1lcu 1rdw 1rfq 1yxq 2a5x 2gwk 2hmp 2q1n 2q1n 2q31 2q31 2q36

14 assemblies; showing the first 12

Homotetramer
8dmx 8ru0 9fjo

3 assemblies

Other homooligomers
2y83 3b5u 3g37 3j8i 3j8j 3j8k 3mfp 4a7n 5mva 5mvy 5onv 5ooc

42 assemblies; showing the first 12

Heteromeric or nucleic-acid complex
1eqy 1esv 1kxp 1lot 1m8q 1ma9 1mvw 1o18 1o19 1o1a 1o1b 1o1c

255 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name ACTS_RABIT
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–377； UniProt 1–377 Author chain D； PDBConstruct 1–377； UniProt 1–377 Author chain F； PDBConstruct 1–377； UniProt 1–377 Author chain I； PDBConstruct 1–377； UniProt 1–377

Gelsolin,Tropomodulin-1 chimera

Homo sapiens

UniProt P06396

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Insufficient information Heteromer Protein 2 Actin, alpha skeletal muscle × 1 （P68135） ADENOSINE-5'-DIPHOSPHATE × 1 CALCIUM ION × 3 water × 2 Consistent with protein count
2 Insufficient information Heteromer Protein 2 Actin, alpha skeletal muscle × 1 （P68135） ADENOSINE-5'-DIPHOSPHATE × 1 CALCIUM ION × 3 water × 2 Consistent with protein count
3 Insufficient information Heteromer Protein 2 Actin, alpha skeletal muscle × 1 （P68135） ADENOSINE-5'-DIPHOSPHATE × 1 CALCIUM ION × 3 water × 2 Consistent with protein count
4 Insufficient information Heteromer Protein 2 Actin, alpha skeletal muscle × 1 （P68135） ADENOSINE-5'-DIPHOSPHATE × 1 CALCIUM ION × 3 water × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1kcq 1p8x 1p8x 1p8x 1sol 2fh1 2fh1 2fh1 2fh2 2fh2 2fh2 2fh3

38 assemblies; showing the first 12

Homodimer
1kcq 5o2z 6jco 6jeg 6jeh

5 assemblies

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1c0f 1c0g 1d4x 1d4x 1dej 1eqy 1esv 1h1v 1mdu 1mdu 1nlv 1nlv

52 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name GELS_HUMAN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain B； PDBConstruct 1–125； UniProt 12–136 Author chain E； PDBConstruct 1–125； UniProt 12–136 Author chain G； PDBConstruct 1–125； UniProt 12–136 Author chain J； PDBConstruct 1–125； UniProt 12–136

Gelsolin,Tropomodulin-1 chimera

Homo sapiens

UniProt P28289

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Insufficient information Heteromer Protein 2 Actin, alpha skeletal muscle × 1 （P68135） ADENOSINE-5'-DIPHOSPHATE × 1 CALCIUM ION × 3 water × 2 Consistent with protein count
2 Insufficient information Heteromer Protein 2 Actin, alpha skeletal muscle × 1 （P68135） ADENOSINE-5'-DIPHOSPHATE × 1 CALCIUM ION × 3 water × 2 Consistent with protein count
3 Insufficient information Heteromer Protein 2 Actin, alpha skeletal muscle × 1 （P68135） ADENOSINE-5'-DIPHOSPHATE × 1 CALCIUM ION × 3 water × 2 Consistent with protein count
4 Insufficient information Heteromer Protein 2 Actin, alpha skeletal muscle × 1 （P68135） ADENOSINE-5'-DIPHOSPHATE × 1 CALCIUM ION × 3 water × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
4pkg 4pkh 4pkh 4pkh 4pkh 4pki 4z8g 4z94 8f8t

9 assemblies

View Construct and Data Evidence
UniProt name TMOD1_HUMAN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain B； PDBConstruct 135–186； UniProt 50–101 Author chain E； PDBConstruct 135–186； UniProt 50–101 Author chain G； PDBConstruct 135–186； UniProt 50–101 Author chain J； PDBConstruct 135–186； UniProt 50–101

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id4pkh
Deposition date deposition_date2014-05-14
Structure title titleComplex of ADP-actin With the N-terminal Actin-Binding Domain of Tropomodulin
Keywords keywords;Tmod, Actin Filament, Pointed-End Capping Protein, Tropomyosin, Contractile Protein, Actin-binding Protein, Contractile Protein-Actin-Binding Protein complex ;; Contractile Protein/Actin-Binding Protein
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

4pkh__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

4pkh__assembly_1__model_1 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

4pkh__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）25.89 Å
Rg (electron density)25.13 Å
Total Rg25.87 Å
Atom count8240
Residues524
Excluded volume74277 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 4pkh__assembly_1__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 4pkh__assembly_2__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
3 1 4pkh__assembly_3__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
4 1 4pkh__assembly_4__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (5)

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6. Fold Classification (SCOP + CATH) 29 domains

SCOP 2.08 (10 domains)

Domain ID domain_idd4pkha1
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.55 — Ribonuclease H-like motif
Superfamily Superfamily superfamilyc.55.1 — Actin-like ATPase domain
Family Family familyc.55.1.1 — Actin/HSP70
Domain ID domain_idd4pkha2
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.55 — Ribonuclease H-like motif
Superfamily Superfamily superfamilyc.55.1 — Actin-like ATPase domain
Family Family familyc.55.1.1 — Actin/HSP70
Domain ID domain_idd4pkhd1
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.55 — Ribonuclease H-like motif
Superfamily Superfamily superfamilyc.55.1 — Actin-like ATPase domain
Family Family familyc.55.1.1 — Actin/HSP70
Domain ID domain_idd4pkhd2
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.55 — Ribonuclease H-like motif
Superfamily Superfamily superfamilyc.55.1 — Actin-like ATPase domain
Family Family familyc.55.1.1 — Actin/HSP70
Domain ID domain_idd4pkhe_
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.109 — Gelsolin-like
Superfamily Superfamily superfamilyd.109.1 — Actin depolymerizing proteins
Family Family familyd.109.1.1 — Gelsolin-like
Domain ID domain_idd4pkhf1
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.55 — Ribonuclease H-like motif
Superfamily Superfamily superfamilyc.55.1 — Actin-like ATPase domain
Family Family familyc.55.1.1 — Actin/HSP70
Domain ID domain_idd4pkhf2
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.55 — Ribonuclease H-like motif
Superfamily Superfamily superfamilyc.55.1 — Actin-like ATPase domain
Family Family familyc.55.1.1 — Actin/HSP70
Domain ID domain_idd4pkhi1
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.55 — Ribonuclease H-like motif
Superfamily Superfamily superfamilyc.55.1 — Actin-like ATPase domain
Family Family familyc.55.1.1 — Actin/HSP70
Domain ID domain_idd4pkhi2
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.55 — Ribonuclease H-like motif
Superfamily Superfamily superfamilyc.55.1 — Actin-like ATPase domain
Family Family familyc.55.1.1 — Actin/HSP70
Domain ID domain_idd4pkhj_
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.109 — Gelsolin-like
Superfamily Superfamily superfamilyd.109.1 — Actin depolymerizing proteins
Family Family familyd.109.1.1 — Gelsolin-like

CATH v4.4 (19 domains)

Domain ID domain_id4pkhA01
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology420 — Nucleotidyltransferase; domain 5
Homologous superfamily homologous superfamily40 — ATPase, nucleotide binding domain
Domain ID domain_id4pkhA02
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology420 — Nucleotidyltransferase; domain 5
Homologous superfamily homologous superfamily40 — ATPase, nucleotide binding domain
Domain ID domain_id4pkhA03
Class class3 — Alpha Beta
Architecture architecture90 — Alpha-Beta Complex
Topology topology640 — Actin; Chain A, domain 4
Homologous superfamily homologous superfamily10 — ATPase, substrate binding domain, subdomain 4
Domain ID domain_id4pkhB00
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology20 — Severin
Homologous superfamily homologous superfamily10 — Severin
Domain ID domain_id4pkhD01
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology420 — Nucleotidyltransferase; domain 5
Homologous superfamily homologous superfamily40 — ATPase, nucleotide binding domain
Domain ID domain_id4pkhD02
Class class2 — Mainly Beta
Architecture architecture30 — Roll
Topology topology36 — Actin; Chain A, domain 2
Homologous superfamily homologous superfamily70 — Actin; Chain A, domain 2
Domain ID domain_id4pkhD03
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology420 — Nucleotidyltransferase; domain 5
Homologous superfamily homologous superfamily40 — ATPase, nucleotide binding domain
Domain ID domain_id4pkhD04
Class class3 — Alpha Beta
Architecture architecture90 — Alpha-Beta Complex
Topology topology640 — Actin; Chain A, domain 4
Homologous superfamily homologous superfamily10 — ATPase, substrate binding domain, subdomain 4
Domain ID domain_id4pkhE00
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology20 — Severin
Homologous superfamily homologous superfamily10 — Severin
Domain ID domain_id4pkhF01
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology420 — Nucleotidyltransferase; domain 5
Homologous superfamily homologous superfamily40 — ATPase, nucleotide binding domain
Domain ID domain_id4pkhF02
Class class2 — Mainly Beta
Architecture architecture30 — Roll
Topology topology36 — Actin; Chain A, domain 2
Homologous superfamily homologous superfamily70 — Actin; Chain A, domain 2
Domain ID domain_id4pkhF03
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology420 — Nucleotidyltransferase; domain 5
Homologous superfamily homologous superfamily40 — ATPase, nucleotide binding domain
Domain ID domain_id4pkhF04
Class class3 — Alpha Beta
Architecture architecture90 — Alpha-Beta Complex
Topology topology640 — Actin; Chain A, domain 4
Homologous superfamily homologous superfamily10 — ATPase, substrate binding domain, subdomain 4
Domain ID domain_id4pkhG00
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology20 — Severin
Homologous superfamily homologous superfamily10 — Severin
Domain ID domain_id4pkhI01
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology420 — Nucleotidyltransferase; domain 5
Homologous superfamily homologous superfamily40 — ATPase, nucleotide binding domain
Domain ID domain_id4pkhI02
Class class2 — Mainly Beta
Architecture architecture30 — Roll
Topology topology36 — Actin; Chain A, domain 2
Homologous superfamily homologous superfamily70 — Actin; Chain A, domain 2
Domain ID domain_id4pkhI03
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology420 — Nucleotidyltransferase; domain 5
Homologous superfamily homologous superfamily40 — ATPase, nucleotide binding domain
Domain ID domain_id4pkhI04
Class class3 — Alpha Beta
Architecture architecture90 — Alpha-Beta Complex
Topology topology640 — Actin; Chain A, domain 4
Homologous superfamily homologous superfamily10 — ATPase, substrate binding domain, subdomain 4
Domain ID domain_id4pkhJ00
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology20 — Severin
Homologous superfamily homologous superfamily10 — Severin
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7. Citations (1)