← Back to search
4reb

Structural Insights into 5' Flap DNA Unwinding and Incision by the Human FAN1 Dimer

Method: X-RAY DIFFRACTION
▼

1. Protein Identity and Related Structures Protein Identity & Related Structures

Fanconi-associated nuclease 1

Homo sapiens

UniProt Q9Y2M0

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–DNA Homooligomer Protein 2 DNA 3 ;DNA (5'-D(P*GP*TP*GP*GP*CP*GP*AP*GP*C)-3') ; × 1 ;DNA (5'-D(P*CP*GP*TP*GP*GP*CP*GP*AP*GP*CP*GP*CP*TP*CP*GP*CP*CP*AP*CP*G)-3') ; × 1 ;DNA (5'-D(P*GP*CP*TP*CP*GP*CP*CP*AP*CP*G)-3') ; × 1 SAMARIUM (III) ION × 2 Consistent with all polymers

Other States of the Same Protein in the Database

Monomer
4rid 4rid 4ry3

3 assemblies

Homodimer

None

Homotetramer
4rid

1 assemblies

Other homooligomers
4ry3

1 assemblies

Heteromeric or nucleic-acid complex
4rea 4reb 4rec 4ri8 4ri8 4ri9 4ri9 4ria 4ria 4rib 4rib 4ric

21 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name FAN1_HUMAN
Isoform —
PDB entities 4
Chains and sequence ranges Author chain A； PDBConstruct 3–647； UniProt 373–1017 Author chain H； PDBConstruct 3–647； UniProt 373–1017

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

▼

2. Structure Basics 2. Structure Basics

Entry ID entry_id4reb
Deposition date deposition_date2014-09-22
Structure title titleStructural Insights into 5' Flap DNA Unwinding and Incision by the Human FAN1 Dimer
Keywords keywordsHJC, TPR, SAP, structure specific nuclease, FANCID2, nucleus, Hydrolase-DNA complex; Hydrolase/DNA
Experimental Method methodX-RAY DIFFRACTION
▼

3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

4reb__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

4reb__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

4reb__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）43.53 Å
Rg (electron density)43.85 Å
Total Rg43.84 Å
Atom count10098
Residues1189
Excluded volume177790 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 4reb__assembly_1__model_1 pentameric （5） Success 4.1.3-1-20251215 (887e7ef) View Download
▶

4. Crystallography and Experiment 4. Crystallography & Experiment

▶

5. Entities and Polymers Entities & Polymers (5)

▶

7. Citations (1)