← Back to search
4uj3

Crystal structure of human Rab11-Rabin8-FIP3

Method: X-RAY DIFFRACTION Dmax: 197.4 Å Quality: GOOD
▼

1. Protein Identity and Related Structures Protein Identity & Related Structures

RAS-RELATED PROTEIN RAB-11A

HOMO SAPIENS

UniProt P62491

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 3 PDB declaration: trimeric（3） Consistent with protein copy count Chain A； UniProt 4–186 Fragment：GTPASE DOMAIN Mutation：YES RAB-3A-INTERACTING PROTEIN × 1 （Q96QF0） RAB11 FAMILY-INTERACTING PROTEIN 3 × 1 （O75154） GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION X-ray crystallization conditions：pH 5.6；50MM MES PH 5.6, 0.2M AMMONIUM SULFATE AND 12% PEG 8000 Resolution 3.00 Å R-free 0.250
2 Protein heterocomplex Heteromer Protein × 3 PDB declaration: trimeric（3） Consistent with protein copy count Chain D； UniProt 4–186 Fragment：GTPASE DOMAIN Mutation：YES RAB-3A-INTERACTING PROTEIN × 1 （Q96QF0） RAB11 FAMILY-INTERACTING PROTEIN 3 × 1 （O75154） GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION X-ray crystallization conditions：pH 5.6；50MM MES PH 5.6, 0.2M AMMONIUM SULFATE AND 12% PEG 8000 Resolution 3.00 Å R-free 0.250
3 Protein heterocomplex Heteromer Protein × 3 PDB declaration: trimeric（3） Consistent with protein copy count Chain G； UniProt 4–186 Fragment：GTPASE DOMAIN Mutation：YES RAB-3A-INTERACTING PROTEIN × 1 （Q96QF0） RAB11 FAMILY-INTERACTING PROTEIN 3 × 1 （O75154） GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION X-ray crystallization conditions：pH 5.6；50MM MES PH 5.6, 0.2M AMMONIUM SULFATE AND 12% PEG 8000 Resolution 3.00 Å R-free 0.250
4 Protein heterocomplex Heteromer Protein × 3 PDB declaration: trimeric（3） Consistent with protein copy count Chain J； UniProt 4–186 Fragment：GTPASE DOMAIN Mutation：YES RAB-3A-INTERACTING PROTEIN × 1 （Q96QF0） RAB11 FAMILY-INTERACTING PROTEIN 3 × 1 （O75154） GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION X-ray crystallization conditions：pH 5.6；50MM MES PH 5.6, 0.2M AMMONIUM SULFATE AND 12% PEG 8000 Resolution 3.00 Å R-free 0.250
5 Protein heterocomplex Heteromer Protein × 3 PDB declaration: trimeric（3） Consistent with protein copy count Chain M； UniProt 4–186 Fragment：GTPASE DOMAIN Mutation：YES RAB-3A-INTERACTING PROTEIN × 1 （Q96QF0） RAB11 FAMILY-INTERACTING PROTEIN 3 × 1 （O75154） GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 MG MAGNESIUM ION × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION X-ray crystallization conditions：pH 5.6；50MM MES PH 5.6, 0.2M AMMONIUM SULFATE AND 12% PEG 8000 Resolution 3.00 Å R-free 0.250
6 Protein heterocomplex Heteromer Protein × 3 PDB declaration: trimeric（3） Consistent with protein copy count Chain P； UniProt 4–186 Fragment：GTPASE DOMAIN Mutation：YES RAB-3A-INTERACTING PROTEIN × 1 （Q96QF0） RAB11 FAMILY-INTERACTING PROTEIN 3 × 1 （O75154） GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION X-ray crystallization conditions：pH 5.6；50MM MES PH 5.6, 0.2M AMMONIUM SULFATE AND 12% PEG 8000 Resolution 3.00 Å R-free 0.250
7 Protein heterocomplex Heteromer Protein × 3 PDB declaration: trimeric（3） Consistent with protein copy count Chain S； UniProt 4–186 Fragment：GTPASE DOMAIN Mutation：YES RAB-3A-INTERACTING PROTEIN × 1 （Q96QF0） RAB11 FAMILY-INTERACTING PROTEIN 3 × 1 （O75154） GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION X-ray crystallization conditions：pH 5.6；50MM MES PH 5.6, 0.2M AMMONIUM SULFATE AND 12% PEG 8000 Resolution 3.00 Å R-free 0.250
8 Protein heterocomplex Heteromer Protein × 3 PDB declaration: trimeric（3） Consistent with protein copy count Chain V； UniProt 4–186 Fragment：GTPASE DOMAIN Mutation：YES RAB-3A-INTERACTING PROTEIN × 1 （Q96QF0） RAB11 FAMILY-INTERACTING PROTEIN 3 × 1 （O75154） GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 MG MAGNESIUM ION × 1 PG4 TETRAETHYLENE GLYCOL × 1 X-RAY DIFFRACTION X-ray crystallization conditions：pH 5.6；50MM MES PH 5.6, 0.2M AMMONIUM SULFATE AND 12% PEG 8000 Resolution 3.00 Å R-free 0.250

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 4UJ3 Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
1YZK GppNHp bound Rab11 GTPase Deposited 2005-02-28 Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 8–175（168 aa）
Not recorded MG MAGNESIUM ION × 1 GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6；277 K；NaCl, Glycerol, MES, pH 6.0, VAPOR DIFFUSION, HANGING DROP, temperature 4K
Resolution 2.00 Å R-free 0.228
2D7C Crystal structure of human Rab11 in complex with FIP3 Rab-binding domain Deposited 2005-11-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 6–172（167 aa） Fragment：residues 7-173
Mutation：Q70L Non-standard monomer：Yes (specific site not provided by mmCIF) MG MAGNESIUM ION × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MES 2-(N-MORPHOLINO)-ETHANESULFONIC ACID × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6；289 K；20% iso-propanol, 3% (w/v) PEG 4000, 0.05M MES-NaOH, pH 6.0, VAPOR DIFFUSION, HANGING DROP, temperature 289K
Resolution 1.75 Å R-free 0.224
2D7C Crystal structure of human Rab11 in complex with FIP3 Rab-binding domain Deposited 2005-11-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain B 6–172（167 aa） Fragment：residues 7-173
Mutation：Q70L Non-standard monomer：Yes (specific site not provided by mmCIF) MG MAGNESIUM ION × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6；289 K；20% iso-propanol, 3% (w/v) PEG 4000, 0.05M MES-NaOH, pH 6.0, VAPOR DIFFUSION, HANGING DROP, temperature 289K
Resolution 1.75 Å R-free 0.224
2GZD Crystal Structure of Rab11 in Complex with Rab11-FIP2 Deposited 2006-05-11 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–172（172 aa） Fragment：G protein domain
Chain B 1–172（172 aa） Fragment：G protein domain
Mutation：Q70L Non-standard monomer：Yes (specific site not provided by mmCIF) Mutation：Q70L Non-standard monomer：Yes (specific site not provided by mmCIF) MG MAGNESIUM ION × 2 GTP GUANOSINE-5'-TRIPHOSPHATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 5；298 K；Ammonium phosphate buffer, between 0.1 and 0.5 M concentration, VAPOR DIFFUSION, temperature 298K
Resolution 2.44 Å R-free 0.279
2GZH Crystal Structure of Rab11 in Complex with Rab11-Family Interacting Protein 2 Deposited 2006-05-11 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 1–172（172 aa） Fragment：G protein domain
Mutation：Q70L Non-standard monomer：Yes (specific site not provided by mmCIF) PO4 PHOSPHATE ION × 2 MG MAGNESIUM ION × 4 GTP GUANOSINE-5'-TRIPHOSPHATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 5；298 K；Ammonium phosphate buffer, approximately 0.3M concentration, pH 5, VAPOR DIFFUSION, temperature 298K
Resolution 2.47 Å R-free 0.254
2HV8 Crystal structure of GTP-bound Rab11 in complex with FIP3 Deposited 2006-07-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 5–174（170 aa） Fragment：GTPase domain
Mutation：Q70L MG MAGNESIUM ION × 2 SO4 SULFATE ION × 2 GTP GUANOSINE-5'-TRIPHOSPHATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；20% PEG4000, 0.4M Ammonium Sulfate, 100mM MES, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
Resolution 1.86 Å R-free 0.237
2HV8 Crystal structure of GTP-bound Rab11 in complex with FIP3 Deposited 2006-07-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 5–174（170 aa） Fragment：GTPase domain
Chain C 5–174（170 aa） Fragment：GTPase domain
Mutation：Q70L Mutation：Q70L MG MAGNESIUM ION × 2 SO4 SULFATE ION × 4 GTP GUANOSINE-5'-TRIPHOSPHATE × 2 2ME METHOXYETHANE × 1 MES 2-(N-MORPHOLINO)-ETHANESULFONIC ACID × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；20% PEG4000, 0.4M Ammonium Sulfate, 100mM MES, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
Resolution 1.86 Å R-free 0.237
4C4P Crystal Structure of Wild-Type Rab11 Complexed to FIP2 Deposited 2013-09-07 Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 1–173（173 aa） Fragment：RESIDUES 1-173
Not recorded GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.00 Å R-free 0.223
4D0L Phosphatidylinositol 4-kinase III beta-PIK93 in a complex with Rab11a- GTP gammaS Deposited 2014-04-29 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain B 1–216（216 aa）
Mutation：YES 093 N-(5-(4-CHLORO-3-(2-HYDROXY-ETHYLSULFAMOYL)- PHENYLTHIAZOLE-2-YL)-ACETAMIDE × 1 GSP 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 5.6；15% (W/V) PEG 4000, 0.1 M NA CITRATE PH 5.6, AND 0.2 M AMMONIUM ACETATE
Resolution 2.94 Å R-free 0.259
4D0L Phosphatidylinositol 4-kinase III beta-PIK93 in a complex with Rab11a- GTP gammaS Deposited 2014-04-29 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain D 1–216（216 aa）
Mutation：YES 093 N-(5-(4-CHLORO-3-(2-HYDROXY-ETHYLSULFAMOYL)- PHENYLTHIAZOLE-2-YL)-ACETAMIDE × 1 GSP 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 5.6；15% (W/V) PEG 4000, 0.1 M NA CITRATE PH 5.6, AND 0.2 M AMMONIUM ACETATE
Resolution 2.94 Å R-free 0.259
4D0L Phosphatidylinositol 4-kinase III beta-PIK93 in a complex with Rab11a- GTP gammaS Deposited 2014-04-29 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain F 1–216（216 aa）
Mutation：YES 093 N-(5-(4-CHLORO-3-(2-HYDROXY-ETHYLSULFAMOYL)- PHENYLTHIAZOLE-2-YL)-ACETAMIDE × 1 GSP 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 5.6；15% (W/V) PEG 4000, 0.1 M NA CITRATE PH 5.6, AND 0.2 M AMMONIUM ACETATE
Resolution 2.94 Å R-free 0.259
4D0M Phosphatidylinositol 4-kinase III beta in a complex with Rab11a-GTP- gamma-S and the Rab-binding domain of FIP3 Deposited 2014-04-29 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 12 PDB declaration: dodecameric
Chain B 1–216（216 aa）
Chain D 1–216（216 aa）
Chain P 1–216（216 aa）
Chain T 1–216（216 aa）
Mutation：YES Mutation：YES Mutation：YES Mutation：YES 093 N-(5-(4-CHLORO-3-(2-HYDROXY-ETHYLSULFAMOYL)- PHENYLTHIAZOLE-2-YL)-ACETAMIDE × 4 GSP 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE × 4 MG MAGNESIUM ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions 16% PEG 6K, 0.01 M NA CITRATE
Resolution 6.00 Å R-free 0.359
4D0M Phosphatidylinositol 4-kinase III beta in a complex with Rab11a-GTP- gamma-S and the Rab-binding domain of FIP3 Deposited 2014-04-29 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 12 PDB declaration: dodecameric
Chain H 1–216（216 aa）
Chain J 1–216（216 aa）
Chain N 1–216（216 aa）
Chain R 1–216（216 aa）
Mutation：YES Mutation：YES Mutation：YES Mutation：YES 093 N-(5-(4-CHLORO-3-(2-HYDROXY-ETHYLSULFAMOYL)- PHENYLTHIAZOLE-2-YL)-ACETAMIDE × 4 GSP 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE × 4 MG MAGNESIUM ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions 16% PEG 6K, 0.01 M NA CITRATE
Resolution 6.00 Å R-free 0.359
4D0M Phosphatidylinositol 4-kinase III beta in a complex with Rab11a-GTP- gamma-S and the Rab-binding domain of FIP3 Deposited 2014-04-29 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 12 PDB declaration: dodecameric
Chain X 1–216（216 aa）
Chain Z 1–216（216 aa）
Chain d 1–216（216 aa）
Chain h 1–216（216 aa）
Mutation：YES Mutation：YES Mutation：YES Mutation：YES 093 N-(5-(4-CHLORO-3-(2-HYDROXY-ETHYLSULFAMOYL)- PHENYLTHIAZOLE-2-YL)-ACETAMIDE × 4 GSP 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE × 4 MG MAGNESIUM ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions 16% PEG 6K, 0.01 M NA CITRATE
Resolution 6.00 Å R-free 0.359
4LWZ Crystal structure of Myo5b globular tail domain in complex with inactive Rab11a Deposited 2013-07-29 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 1–177（177 aa） Fragment：Dilute domain residues 1456-1848
Not recorded GDP GUANOSINE-5'-DIPHOSPHATE × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8；298 K；17% peg, 100 mM NaCl, pH 8, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 2.55 Å R-free 0.295
4LWZ Crystal structure of Myo5b globular tail domain in complex with inactive Rab11a Deposited 2013-07-29 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain C 1–177（177 aa） Fragment：Dilute domain residues 1456-1848
Not recorded GDP GUANOSINE-5'-DIPHOSPHATE × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8；298 K；17% peg, 100 mM NaCl, pH 8, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 2.55 Å R-free 0.295
4LX0 Crystal structure of Myo5b globular tail domain in complex with active Rab11a Deposited 2013-07-29 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 1–177（177 aa） Fragment：Dilute domain residues 1456-1848
Not recorded MG MAGNESIUM ION × 1 BEF BERYLLIUM TRIFLUORIDE ION × 1 GDP GUANOSINE-5'-DIPHOSPHATE × 1 GOL GLYCEROL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8；298 K；10 % peg, 90 mM NaF, pH 8, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 2.19 Å R-free 0.218
4LX0 Crystal structure of Myo5b globular tail domain in complex with active Rab11a Deposited 2013-07-29 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain C 1–177（177 aa） Fragment：Dilute domain residues 1456-1848
Not recorded MG MAGNESIUM ION × 1 BEF BERYLLIUM TRIFLUORIDE ION × 1 GDP GUANOSINE-5'-DIPHOSPHATE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8；298 K；10 % peg, 90 mM NaF, pH 8, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 2.19 Å R-free 0.218
4UJ4 Crystal structure of human Rab11-Rabin8-FIP3 Deposited 2015-04-08 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric
Chain D 4–186（183 aa） Fragment：GTPASE DOMAIN, RESIDUES 4-186
Chain G 4–186（183 aa） Fragment：GTPASE DOMAIN, RESIDUES 4-186
Mutation：YES Mutation：YES GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 2 MG MAGNESIUM ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 5.8；50MM MES PH 5.8, 0.2M AMMONIUM SULFATE AND 14% PEG 8000
Resolution 4.20 Å R-free 0.266
4UJ4 Crystal structure of human Rab11-Rabin8-FIP3 Deposited 2015-04-08 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric
Chain A 4–186（183 aa） Fragment：GTPASE DOMAIN, RESIDUES 4-186
Chain J 4–186（183 aa） Fragment：GTPASE DOMAIN, RESIDUES 4-186
Mutation：YES Mutation：YES GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 2 MG MAGNESIUM ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 5.8；50MM MES PH 5.8, 0.2M AMMONIUM SULFATE AND 14% PEG 8000
Resolution 4.20 Å R-free 0.266
4UJ4 Crystal structure of human Rab11-Rabin8-FIP3 Deposited 2015-04-08 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric
Chain A 4–186（183 aa） Fragment：GTPASE DOMAIN, RESIDUES 4-186
Chain J 4–186（183 aa） Fragment：GTPASE DOMAIN, RESIDUES 4-186
Mutation：YES Mutation：YES GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 2 MG MAGNESIUM ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 5.8；50MM MES PH 5.8, 0.2M AMMONIUM SULFATE AND 14% PEG 8000
Resolution 4.20 Å R-free 0.266
4UJ5 Crystal structure of human Rab11-Rabin8-FIP3 Deposited 2015-04-08 Different construct Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 6–186（181 aa） Fragment：GTPASE DOMAIN, RESIDUES 6-186
Mutation：YES GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 MG MAGNESIUM ION × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7；0.1M HEPES PH 7.0, 0.2M LITHIUM SULFATE AND 24% PEG 3350
Resolution 2.60 Å R-free 0.272
4UJ5 Crystal structure of human Rab11-Rabin8-FIP3 Deposited 2015-04-08 Different construct Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain B 6–186（181 aa） Fragment：GTPASE DOMAIN, RESIDUES 6-186
Mutation：YES GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7；0.1M HEPES PH 7.0, 0.2M LITHIUM SULFATE AND 24% PEG 3350
Resolution 2.60 Å R-free 0.272
5C46 Crystal structure of an engineered construct of phosphatidylinositol 4 kinase III beta in complex with GTP gamma S loaded Rab11 Deposited 2015-06-17 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain F 1–216（216 aa）
Mutation：Q70L SO4 SULFATE ION × 2 GSP 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.6；290 K；PEG-4000, sodium citrate, ammonium sulfate, glycerol
Resolution 2.65 Å R-free 0.246
5C4G Crystal structure of an engineered construct of phosphatidylinositol 4 kinase III beta with the inhibitor BQR695 in complex with GDP loaded Rab11 Deposited 2015-06-18 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain B 1–216（216 aa）
Mutation：Q70L MG MAGNESIUM ION × 1 GDP GUANOSINE-5'-DIPHOSPHATE × 1 SO4 SULFATE ION × 2 BQR N~2~-[7-(3,4-dimethoxyphenyl)quinoxalin-2-yl]-N-methylglycinamide × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.6；290 K；PEG-4000, sodium citrate, ammonium sulfate, glycerol
Resolution 3.20 Å R-free 0.287
5EUQ Crystal structure of an engineered construct of phosphatidylinositol 4 kinase III beta with a potent and selective inhibitor in complex with GDP loaded Rab11 Deposited 2015-11-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric
Chain B 1–216（216 aa）
Not recorded GDP GUANOSINE-5'-DIPHOSPHATE × 1 SO4 SULFATE ION × 2 5S8 ~{N}-[5-[3-[[(4-hydroxyphenyl)amino]-bis(oxidanyl)-$l^{4}-sulfanyl]-4-methoxy-phenyl]-4-methyl-1,3-thiazol-2-yl]cyclopentanecarboxamide × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 5.6；290 K；PEG-4000, sodium citrate, ammonium sulfate, glycerol
Resolution 3.20 Å R-free 0.266
5EZ5 Crystal structure of active Rab11A (S20V) in complex with GTP Deposited 2015-11-26 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 8–175（168 aa） Fragment：UNP residues 8-175
Chain B 8–175（168 aa） Fragment：UNP residues 8-175
Mutation：S20V Mutation：S20V MG MAGNESIUM ION × 2 GTP GUANOSINE-5'-TRIPHOSPHATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；Sodium chloride, Tris, Magnessium chloride
Resolution 2.40 Å R-free 0.304
5EZ5 Crystal structure of active Rab11A (S20V) in complex with GTP Deposited 2015-11-26 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 8–175（168 aa） Fragment：UNP residues 8-175
Chain B 8–175（168 aa） Fragment：UNP residues 8-175
Mutation：S20V Mutation：S20V MG MAGNESIUM ION × 2 GTP GUANOSINE-5'-TRIPHOSPHATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；Sodium chloride, Tris, Magnessium chloride
Resolution 2.40 Å R-free 0.304
5FBL PI4KB in complex with Rab11 and the MI356 Inhibitor Deposited 2015-12-14 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain B 1–216（216 aa）
Not recorded 5W9 ~{N}-[2-[[6-chloranyl-3-(4-methoxy-3-morpholin-4-ylsulfonyl-phenyl)-2-methyl-imidazo[1,2-b]pyridazin-8-yl]amino]ethyl]ethanamide × 1 GSP 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；291 K；1M Lithium chloride, 0.1M Citric acid pH=5, 10% (w/v) PEG 6000
Resolution 3.37 Å R-free 0.269
5FBQ PI4KB in complex with Rab11 and the MI358 Inhibitor Deposited 2015-12-14 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain B 1–216（216 aa）
Not recorded 5W6 ~{N}-[2-[[6-chloranyl-3-[3-[4-(hydroxymethyl)piperidin-1-yl]sulfonyl-4-methoxy-phenyl]-2-methyl-imidazo[1,2-b]pyridazin-8-yl]amino]ethyl]ethanamide × 1 GDP GUANOSINE-5'-DIPHOSPHATE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；291 K；0.2M magnesium chloride, 0.1M Tris PH=7, 10% (w/v) PEG 8000
Resolution 3.79 Å R-free 0.302
5FBR PI4KB in complex with Rab11 and the MI359 Inhibitor Deposited 2015-12-14 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain B 1–216（216 aa）
Not recorded 5W7 ~{N}-[2-[[3-[3-[(4-azanylcyclohexyl)sulfamoyl]-4-methoxy-phenyl]-6-chloranyl-2-methyl-imidazo[1,2-b]pyridazin-8-yl]amino]ethyl]ethanamide × 1 GSP 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；291 K；0.15M amonium sulfate, 0.1M MES pH=6, 15% PEG 4000
Resolution 3.28 Å R-free 0.264
5FBV PI4KB in complex with Rab11 and the MI364 Inhibitor Deposited 2015-12-14 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain B 1–216（216 aa）
Not recorded 5W3 ~{N}-[2-[[6-chloranyl-3-[3-(2-hydroxyethylsulfamoyl)-4-methoxy-phenyl]-2-methyl-imidazo[1,2-b]pyridazin-8-yl]amino]ethy l]ethanamide × 1 GSP 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；291 K；0.15M amonium sulfate, 0.1M MEW pH=6, 15% PEG 4000
Resolution 3.29 Å R-free 0.281
5FBW PI4KB in complex with Rab11 and the MI369 Inhibitor Deposited 2015-12-14 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain B 1–216（216 aa）
Not recorded 5W8 ~{N}-[2-[[6-chloranyl-3-[4-methoxy-3-[[(2~{R})-1-oxidanylbutan-2-yl]sulfamoyl]phenyl]-2-methyl-imidazo[1,2-b]pyridazin-8-yl]amino]ethyl]ethanamide × 1 GSP 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；291 K；0.2M ammonium sulfate, 0.1M MES pH=6.5, 20% (w/v) PEG 8000
Resolution 3.49 Å R-free 0.283
5JCZ Rab11 bound to MyoVa-GTD Deposited 2016-04-15 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 1–177（177 aa）
Not recorded MG MAGNESIUM ION × 1 GDP GUANOSINE-5'-DIPHOSPHATE × 1 BEF BERYLLIUM TRIFLUORIDE ION × 1 EDO 1,2-ETHANEDIOL × 5 ACT ACETATE ION × 1 GOL GLYCEROL × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；290 K；7% (w/v) PEG-8000, 50 mM Bicine, 50 mM Tris, 30mM sodium fluoride, 20% (v/v) ethylene glycol
Resolution 2.06 Å R-free 0.208
5JCZ Rab11 bound to MyoVa-GTD Deposited 2016-04-15 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain D 1–177（177 aa）
Not recorded MG MAGNESIUM ION × 2 GDP GUANOSINE-5'-DIPHOSPHATE × 1 BEF BERYLLIUM TRIFLUORIDE ION × 1 EDO 1,2-ETHANEDIOL × 6 ACT ACETATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；290 K；7% (w/v) PEG-8000, 50 mM Bicine, 50 mM Tris, 30mM sodium fluoride, 20% (v/v) ethylene glycol
Resolution 2.06 Å R-free 0.208
5JCZ Rab11 bound to MyoVa-GTD Deposited 2016-04-15 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain I 1–177（177 aa）
Not recorded MG MAGNESIUM ION × 1 GDP GUANOSINE-5'-DIPHOSPHATE × 1 BEF BERYLLIUM TRIFLUORIDE ION × 1 EDO 1,2-ETHANEDIOL × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；290 K；7% (w/v) PEG-8000, 50 mM Bicine, 50 mM Tris, 30mM sodium fluoride, 20% (v/v) ethylene glycol
Resolution 2.06 Å R-free 0.208
6DJL Crystal structure of the Rab11 GEF SH3BP5 bound to nucleotide free Rab11A Deposited 2018-05-25 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 1–216（216 aa）
Mutation：Q70L No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；289 K；23% PEG-3350, 200 mM NaCl, 100 mM Bis Tris pH-6.5
Resolution 3.10 Å R-free 0.278
6DJL Crystal structure of the Rab11 GEF SH3BP5 bound to nucleotide free Rab11A Deposited 2018-05-25 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain H 1–216（216 aa）
Mutation：Q70L No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；289 K；23% PEG-3350, 200 mM NaCl, 100 mM Bis Tris pH-6.5
Resolution 3.10 Å R-free 0.278
6DJL Crystal structure of the Rab11 GEF SH3BP5 bound to nucleotide free Rab11A Deposited 2018-05-25 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain G 1–216（216 aa）
Mutation：Q70L No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；289 K；23% PEG-3350, 200 mM NaCl, 100 mM Bis Tris pH-6.5
Resolution 3.10 Å R-free 0.278
6DJL Crystal structure of the Rab11 GEF SH3BP5 bound to nucleotide free Rab11A Deposited 2018-05-25 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 4 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain F 1–216（216 aa）
Mutation：Q70L No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；289 K；23% PEG-3350, 200 mM NaCl, 100 mM Bis Tris pH-6.5
Resolution 3.10 Å R-free 0.278
6IXV Crystal structure of SH3BP5-Rab11a Deposited 2018-12-12 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain E 1–173（173 aa）
Not recorded PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；0.6M NaCl, 0.1M NaH2PO4 pH 6.8, 16% PEG 2000
Resolution 3.80 Å R-free 0.259
6IXV Crystal structure of SH3BP5-Rab11a Deposited 2018-12-12 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain F 1–173（173 aa）
Not recorded PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；0.6M NaCl, 0.1M NaH2PO4 pH 6.8, 16% PEG 2000
Resolution 3.80 Å R-free 0.259
6IXV Crystal structure of SH3BP5-Rab11a Deposited 2018-12-12 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain G 1–173（173 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；0.6M NaCl, 0.1M NaH2PO4 pH 6.8, 16% PEG 2000
Resolution 3.80 Å R-free 0.259
6IXV Crystal structure of SH3BP5-Rab11a Deposited 2018-12-12 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 4 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain H 1–173（173 aa）
Not recorded PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；0.6M NaCl, 0.1M NaH2PO4 pH 6.8, 16% PEG 2000
Resolution 3.80 Å R-free 0.259
6IY1 Structure of human Ras-related protein Rab11 Deposited 2018-12-12 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 9–173（165 aa）
Not recorded GDP GUANOSINE-5'-DIPHOSPHATE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；0.15M Li2SO4, 0.1M Glycine, 0.8M NaH2PO4 1.2M Na2HPO4
Resolution 2.11 Å R-free 0.261
6IY1 Structure of human Ras-related protein Rab11 Deposited 2018-12-12 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 9–173（165 aa）
Not recorded GDP GUANOSINE-5'-DIPHOSPHATE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；0.15M Li2SO4, 0.1M Glycine, 0.8M NaH2PO4 1.2M Na2HPO4
Resolution 2.11 Å R-free 0.261
6IY1 Structure of human Ras-related protein Rab11 Deposited 2018-12-12 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain C 9–173（165 aa）
Not recorded GDP GUANOSINE-5'-DIPHOSPHATE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；0.15M Li2SO4, 0.1M Glycine, 0.8M NaH2PO4 1.2M Na2HPO4
Resolution 2.11 Å R-free 0.261
6IY1 Structure of human Ras-related protein Rab11 Deposited 2018-12-12 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain D 7–173（167 aa）
Not recorded GDP GUANOSINE-5'-DIPHOSPHATE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；0.15M Li2SO4, 0.1M Glycine, 0.8M NaH2PO4 1.2M Na2HPO4
Resolution 2.11 Å R-free 0.261
6IY1 Structure of human Ras-related protein Rab11 Deposited 2018-12-12 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 5 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain E 9–173（165 aa）
Not recorded GDP GUANOSINE-5'-DIPHOSPHATE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；0.15M Li2SO4, 0.1M Glycine, 0.8M NaH2PO4 1.2M Na2HPO4
Resolution 2.11 Å R-free 0.261
6IY1 Structure of human Ras-related protein Rab11 Deposited 2018-12-12 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 6 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain F 6–173（168 aa）
Not recorded GDP GUANOSINE-5'-DIPHOSPHATE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；0.15M Li2SO4, 0.1M Glycine, 0.8M NaH2PO4 1.2M Na2HPO4
Resolution 2.11 Å R-free 0.261
8VOF GI targeted CpPI4K inhibitor Deposited 2024-01-15 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain B 1–216（216 aa）
Mutation：Q70L A1ADE methyl 2-chloro-5-(methyl{(8R)-3-[4-(methylcarbamoyl)phenyl]pyrazolo[1,5-a]pyridine-5-carbonyl}amino)benzoate × 1 SO4 SULFATE ION × 1 GDP GUANOSINE-5'-DIPHOSPHATE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8；294 K；0.5M ammonium sulfate, 0.088M sodium citrate, 0.875M lithium sulfate, 2.4% glycerol, 2.5% ethylene glycol, 50mM HEPES pH 6.8
Resolution 3.00 Å R-free 0.270

26 other PDB entries and 51 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name RB11A_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 5–187； UniProt 4–186 Author chain D； PDBConstruct 5–187； UniProt 4–186 Author chain G； PDBConstruct 5–187； UniProt 4–186 Author chain J； PDBConstruct 5–187； UniProt 4–186 Author chain M； PDBConstruct 5–187； UniProt 4–186 Author chain P； PDBConstruct 5–187； UniProt 4–186 Author chain S； PDBConstruct 5–187； UniProt 4–186 Author chain V； PDBConstruct 5–187； UniProt 4–186

RAB-3A-INTERACTING PROTEIN

HOMO SAPIENS

UniProt Q96QF0

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 3 PDB declaration: trimeric（3） Consistent with protein copy count Chain B； UniProt 286–476 Fragment：C-TERMINAL DOMAIN RAS-RELATED PROTEIN RAB-11A × 1 （P62491） RAB11 FAMILY-INTERACTING PROTEIN 3 × 1 （O75154） GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION X-ray crystallization conditions：pH 5.6；50MM MES PH 5.6, 0.2M AMMONIUM SULFATE AND 12% PEG 8000 Resolution 3.00 Å R-free 0.250
2 Protein heterocomplex Heteromer Protein × 3 PDB declaration: trimeric（3） Consistent with protein copy count Chain E； UniProt 286–476 Fragment：C-TERMINAL DOMAIN RAS-RELATED PROTEIN RAB-11A × 1 （P62491） RAB11 FAMILY-INTERACTING PROTEIN 3 × 1 （O75154） GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION X-ray crystallization conditions：pH 5.6；50MM MES PH 5.6, 0.2M AMMONIUM SULFATE AND 12% PEG 8000 Resolution 3.00 Å R-free 0.250
3 Protein heterocomplex Heteromer Protein × 3 PDB declaration: trimeric（3） Consistent with protein copy count Chain H； UniProt 286–476 Fragment：C-TERMINAL DOMAIN RAS-RELATED PROTEIN RAB-11A × 1 （P62491） RAB11 FAMILY-INTERACTING PROTEIN 3 × 1 （O75154） GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION X-ray crystallization conditions：pH 5.6；50MM MES PH 5.6, 0.2M AMMONIUM SULFATE AND 12% PEG 8000 Resolution 3.00 Å R-free 0.250
4 Protein heterocomplex Heteromer Protein × 3 PDB declaration: trimeric（3） Consistent with protein copy count Chain K； UniProt 286–476 Fragment：C-TERMINAL DOMAIN RAS-RELATED PROTEIN RAB-11A × 1 （P62491） RAB11 FAMILY-INTERACTING PROTEIN 3 × 1 （O75154） GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION X-ray crystallization conditions：pH 5.6；50MM MES PH 5.6, 0.2M AMMONIUM SULFATE AND 12% PEG 8000 Resolution 3.00 Å R-free 0.250
5 Protein heterocomplex Heteromer Protein × 3 PDB declaration: trimeric（3） Consistent with protein copy count Chain N； UniProt 286–476 Fragment：C-TERMINAL DOMAIN RAS-RELATED PROTEIN RAB-11A × 1 （P62491） RAB11 FAMILY-INTERACTING PROTEIN 3 × 1 （O75154） GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 MG MAGNESIUM ION × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION X-ray crystallization conditions：pH 5.6；50MM MES PH 5.6, 0.2M AMMONIUM SULFATE AND 12% PEG 8000 Resolution 3.00 Å R-free 0.250
6 Protein heterocomplex Heteromer Protein × 3 PDB declaration: trimeric（3） Consistent with protein copy count Chain Q； UniProt 286–476 Fragment：C-TERMINAL DOMAIN RAS-RELATED PROTEIN RAB-11A × 1 （P62491） RAB11 FAMILY-INTERACTING PROTEIN 3 × 1 （O75154） GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION X-ray crystallization conditions：pH 5.6；50MM MES PH 5.6, 0.2M AMMONIUM SULFATE AND 12% PEG 8000 Resolution 3.00 Å R-free 0.250
7 Protein heterocomplex Heteromer Protein × 3 PDB declaration: trimeric（3） Consistent with protein copy count Chain T； UniProt 286–476 Fragment：C-TERMINAL DOMAIN RAS-RELATED PROTEIN RAB-11A × 1 （P62491） RAB11 FAMILY-INTERACTING PROTEIN 3 × 1 （O75154） GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION X-ray crystallization conditions：pH 5.6；50MM MES PH 5.6, 0.2M AMMONIUM SULFATE AND 12% PEG 8000 Resolution 3.00 Å R-free 0.250
8 Protein heterocomplex Heteromer Protein × 3 PDB declaration: trimeric（3） Consistent with protein copy count Chain W； UniProt 286–476 Fragment：C-TERMINAL DOMAIN RAS-RELATED PROTEIN RAB-11A × 1 （P62491） RAB11 FAMILY-INTERACTING PROTEIN 3 × 1 （O75154） GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 MG MAGNESIUM ION × 1 PG4 TETRAETHYLENE GLYCOL × 1 X-RAY DIFFRACTION X-ray crystallization conditions：pH 5.6；50MM MES PH 5.6, 0.2M AMMONIUM SULFATE AND 12% PEG 8000 Resolution 3.00 Å R-free 0.250

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 4UJ3 Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
4LHX Crystal structure of nucleotide-free Rab8:Rabin8 Deposited 2013-07-01 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain E 173–248（76 aa） Fragment：unp residues 157-232
Chain F 173–248（76 aa） Fragment：unp residues 157-232
Not recorded SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.6；293 K；18% (w/v) PEG3350, 0.1 M Li2SO4, 0.1 M MES. cryo solution (30% (w/v) PEG3350, 0.1 M Li2SO4, 0.1 M MES), pH 6.6, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 3.05 Å R-free 0.300
4LHX Crystal structure of nucleotide-free Rab8:Rabin8 Deposited 2013-07-01 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain C 173–248（76 aa） Fragment：unp residues 157-232
Chain D 173–248（76 aa） Fragment：unp residues 157-232
Not recorded SO4 SULFATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.6；293 K；18% (w/v) PEG3350, 0.1 M Li2SO4, 0.1 M MES. cryo solution (30% (w/v) PEG3350, 0.1 M Li2SO4, 0.1 M MES), pH 6.6, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 3.05 Å R-free 0.300
4LHY Crystal structure of GDP-bound Rab8:Rabin8 Deposited 2013-07-01 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain E 173–248（76 aa） Fragment：unp residues 173-248
Chain F 173–248（76 aa） Fragment：unp residues 173-248
Not recorded GDP GUANOSINE-5'-DIPHOSPHATE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.6；293 K；Nucleotide-free Rab8a1 184:Rabin8157-232 was crystallized in 18% (w/v) PEG3350, 0.1 M Li2SO4, 0.1 M MES pH 6.6. Before data collection, the complex crystal was protected with cryo solution (30% (w/v) PEG3350, 0.1 M Li2SO4, 0.1 M MES pH 6.6). In order to produce nucleotide-bound forms of Rab8:Rabin8 complexes, the nucleotide-free Rab8:Rabin8 crystals were soaked with cryo solution containing 30 % (w/v) PEG3350, 0.1 M Li2SO4, 0.1 M MES pH 6.6 and 1 mM respective nucleotide GDP/GTP for one hour at 4 C, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 3.10 Å R-free 0.310
4LHY Crystal structure of GDP-bound Rab8:Rabin8 Deposited 2013-07-01 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain C 173–248（76 aa） Fragment：unp residues 173-248
Chain D 173–248（76 aa） Fragment：unp residues 173-248
Not recorded GDP GUANOSINE-5'-DIPHOSPHATE × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.6；293 K；Nucleotide-free Rab8a1 184:Rabin8157-232 was crystallized in 18% (w/v) PEG3350, 0.1 M Li2SO4, 0.1 M MES pH 6.6. Before data collection, the complex crystal was protected with cryo solution (30% (w/v) PEG3350, 0.1 M Li2SO4, 0.1 M MES pH 6.6). In order to produce nucleotide-bound forms of Rab8:Rabin8 complexes, the nucleotide-free Rab8:Rabin8 crystals were soaked with cryo solution containing 30 % (w/v) PEG3350, 0.1 M Li2SO4, 0.1 M MES pH 6.6 and 1 mM respective nucleotide GDP/GTP for one hour at 4 C, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 3.10 Å R-free 0.310
4LHZ Crystal structure of GTP-bound Rab8:Rabin8 Deposited 2013-07-01 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain E 173–248（76 aa） Fragment：unp residues 173-248
Chain F 173–248（76 aa） Fragment：unp residues 173-248
Not recorded GTP GUANOSINE-5'-TRIPHOSPHATE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.6；293 K；Nucleotide-free Rab8a1 184:Rabin8157-232 was crystallized in 18% (w/v) PEG3350, 0.1 M Li2SO4, 0.1 M MES pH 6.6. Before data collection, the complex crystal was protected with cryo solution (30% (w/v) PEG3350, 0.1 M Li2SO4, 0.1 M MES pH 6.6). In order to produce nucleotide-bound forms of Rab8:Rabin8 complexes, the nucleotide-free Rab8:Rabin8 crystals were soaked with cryo solution containing 30 % (w/v) PEG3350, 0.1 M Li2SO4, 0.1 M MES pH 6.6 and 1 mM respective nucleotide GDP/GTP for one hours at 278 K, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 3.20 Å R-free 0.309
4LHZ Crystal structure of GTP-bound Rab8:Rabin8 Deposited 2013-07-01 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain C 173–248（76 aa） Fragment：unp residues 173-248
Chain D 173–248（76 aa） Fragment：unp residues 173-248
Not recorded GTP GUANOSINE-5'-TRIPHOSPHATE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.6；293 K；Nucleotide-free Rab8a1 184:Rabin8157-232 was crystallized in 18% (w/v) PEG3350, 0.1 M Li2SO4, 0.1 M MES pH 6.6. Before data collection, the complex crystal was protected with cryo solution (30% (w/v) PEG3350, 0.1 M Li2SO4, 0.1 M MES pH 6.6). In order to produce nucleotide-bound forms of Rab8:Rabin8 complexes, the nucleotide-free Rab8:Rabin8 crystals were soaked with cryo solution containing 30 % (w/v) PEG3350, 0.1 M Li2SO4, 0.1 M MES pH 6.6 and 1 mM respective nucleotide GDP/GTP for one hours at 278 K, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 3.20 Å R-free 0.309
4UJ4 Crystal structure of human Rab11-Rabin8-FIP3 Deposited 2015-04-08 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric
Chain E 286–476（191 aa） Fragment：C-TERMINAL DOMAIN, UNP RESIDUES 286-476
Chain H 286–476（191 aa） Fragment：C-TERMINAL DOMAIN, UNP RESIDUES 286-476
Not recorded GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 2 MG MAGNESIUM ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 5.8；50MM MES PH 5.8, 0.2M AMMONIUM SULFATE AND 14% PEG 8000
Resolution 4.20 Å R-free 0.266
4UJ4 Crystal structure of human Rab11-Rabin8-FIP3 Deposited 2015-04-08 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric
Chain B 286–476（191 aa） Fragment：C-TERMINAL DOMAIN, UNP RESIDUES 286-476
Chain K 286–476（191 aa） Fragment：C-TERMINAL DOMAIN, UNP RESIDUES 286-476
Not recorded GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 2 MG MAGNESIUM ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 5.8；50MM MES PH 5.8, 0.2M AMMONIUM SULFATE AND 14% PEG 8000
Resolution 4.20 Å R-free 0.266
4UJ4 Crystal structure of human Rab11-Rabin8-FIP3 Deposited 2015-04-08 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric
Chain B 286–476（191 aa） Fragment：C-TERMINAL DOMAIN, UNP RESIDUES 286-476
Chain K 286–476（191 aa） Fragment：C-TERMINAL DOMAIN, UNP RESIDUES 286-476
Not recorded GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 2 MG MAGNESIUM ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 5.8；50MM MES PH 5.8, 0.2M AMMONIUM SULFATE AND 14% PEG 8000
Resolution 4.20 Å R-free 0.266
4UJ5 Crystal structure of human Rab11-Rabin8-FIP3 Deposited 2015-04-08 Different construct Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain C 286–476（191 aa） Fragment：C-TERMINAL DOMAIN, RESIDUES 286-476
Not recorded GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 MG MAGNESIUM ION × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7；0.1M HEPES PH 7.0, 0.2M LITHIUM SULFATE AND 24% PEG 3350
Resolution 2.60 Å R-free 0.272
4UJ5 Crystal structure of human Rab11-Rabin8-FIP3 Deposited 2015-04-08 Different construct Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain D 286–476（191 aa） Fragment：C-TERMINAL DOMAIN, RESIDUES 286-476
Not recorded GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7；0.1M HEPES PH 7.0, 0.2M LITHIUM SULFATE AND 24% PEG 3350
Resolution 2.60 Å R-free 0.272
6F6P Crystal structure of tetrameric human Rabin8 GEF domain Deposited 2017-12-06 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric
Chain A 159–261（103 aa）
Chain B 159–261（103 aa）
Chain C 159–261（103 aa）
Chain D 159–261（103 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.3；291 K；50 mM Tris pH 7.3 and 40% MPD
Resolution 2.45 Å R-free 0.305

6 other PDB entries and 12 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name RAB3I_HUMAN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain B； PDBConstruct 5–195； UniProt 286–476 Author chain E； PDBConstruct 5–195； UniProt 286–476 Author chain H； PDBConstruct 5–195； UniProt 286–476 Author chain K； PDBConstruct 5–195； UniProt 286–476 Author chain N； PDBConstruct 5–195； UniProt 286–476 Author chain Q； PDBConstruct 5–195； UniProt 286–476 Author chain T； PDBConstruct 5–195； UniProt 286–476 Author chain W； PDBConstruct 5–195； UniProt 286–476

RAB11 FAMILY-INTERACTING PROTEIN 3

HOMO SAPIENS

UniProt O75154

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 3 PDB declaration: trimeric（3） Consistent with protein copy count Chain C； UniProt 695–756 Fragment：C-TERMINAL DOMAIN RAS-RELATED PROTEIN RAB-11A × 1 （P62491） RAB-3A-INTERACTING PROTEIN × 1 （Q96QF0） GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION X-ray crystallization conditions：pH 5.6；50MM MES PH 5.6, 0.2M AMMONIUM SULFATE AND 12% PEG 8000 Resolution 3.00 Å R-free 0.250
2 Protein heterocomplex Heteromer Protein × 3 PDB declaration: trimeric（3） Consistent with protein copy count Chain F； UniProt 695–756 Fragment：C-TERMINAL DOMAIN RAS-RELATED PROTEIN RAB-11A × 1 （P62491） RAB-3A-INTERACTING PROTEIN × 1 （Q96QF0） GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION X-ray crystallization conditions：pH 5.6；50MM MES PH 5.6, 0.2M AMMONIUM SULFATE AND 12% PEG 8000 Resolution 3.00 Å R-free 0.250
3 Protein heterocomplex Heteromer Protein × 3 PDB declaration: trimeric（3） Consistent with protein copy count Chain I； UniProt 695–756 Fragment：C-TERMINAL DOMAIN RAS-RELATED PROTEIN RAB-11A × 1 （P62491） RAB-3A-INTERACTING PROTEIN × 1 （Q96QF0） GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION X-ray crystallization conditions：pH 5.6；50MM MES PH 5.6, 0.2M AMMONIUM SULFATE AND 12% PEG 8000 Resolution 3.00 Å R-free 0.250
4 Protein heterocomplex Heteromer Protein × 3 PDB declaration: trimeric（3） Consistent with protein copy count Chain L； UniProt 695–756 Fragment：C-TERMINAL DOMAIN RAS-RELATED PROTEIN RAB-11A × 1 （P62491） RAB-3A-INTERACTING PROTEIN × 1 （Q96QF0） GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION X-ray crystallization conditions：pH 5.6；50MM MES PH 5.6, 0.2M AMMONIUM SULFATE AND 12% PEG 8000 Resolution 3.00 Å R-free 0.250
5 Protein heterocomplex Heteromer Protein × 3 PDB declaration: trimeric（3） Consistent with protein copy count Chain O； UniProt 695–756 Fragment：C-TERMINAL DOMAIN RAS-RELATED PROTEIN RAB-11A × 1 （P62491） RAB-3A-INTERACTING PROTEIN × 1 （Q96QF0） GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 MG MAGNESIUM ION × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION X-ray crystallization conditions：pH 5.6；50MM MES PH 5.6, 0.2M AMMONIUM SULFATE AND 12% PEG 8000 Resolution 3.00 Å R-free 0.250
6 Protein heterocomplex Heteromer Protein × 3 PDB declaration: trimeric（3） Consistent with protein copy count Chain R； UniProt 695–756 Fragment：C-TERMINAL DOMAIN RAS-RELATED PROTEIN RAB-11A × 1 （P62491） RAB-3A-INTERACTING PROTEIN × 1 （Q96QF0） GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION X-ray crystallization conditions：pH 5.6；50MM MES PH 5.6, 0.2M AMMONIUM SULFATE AND 12% PEG 8000 Resolution 3.00 Å R-free 0.250
7 Protein heterocomplex Heteromer Protein × 3 PDB declaration: trimeric（3） Consistent with protein copy count Chain U； UniProt 695–756 Fragment：C-TERMINAL DOMAIN RAS-RELATED PROTEIN RAB-11A × 1 （P62491） RAB-3A-INTERACTING PROTEIN × 1 （Q96QF0） GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION X-ray crystallization conditions：pH 5.6；50MM MES PH 5.6, 0.2M AMMONIUM SULFATE AND 12% PEG 8000 Resolution 3.00 Å R-free 0.250
8 Protein heterocomplex Heteromer Protein × 3 PDB declaration: trimeric（3） Consistent with protein copy count Chain X； UniProt 695–756 Fragment：C-TERMINAL DOMAIN RAS-RELATED PROTEIN RAB-11A × 1 （P62491） RAB-3A-INTERACTING PROTEIN × 1 （Q96QF0） GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 MG MAGNESIUM ION × 1 PG4 TETRAETHYLENE GLYCOL × 1 X-RAY DIFFRACTION X-ray crystallization conditions：pH 5.6；50MM MES PH 5.6, 0.2M AMMONIUM SULFATE AND 12% PEG 8000 Resolution 3.00 Å R-free 0.250

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 4UJ3 Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
2D7C Crystal structure of human Rab11 in complex with FIP3 Rab-binding domain Deposited 2005-11-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain C 715–756（42 aa） Fragment：Rab-binding domain
Non-standard monomer：Yes (specific site not provided by mmCIF) MG MAGNESIUM ION × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MES 2-(N-MORPHOLINO)-ETHANESULFONIC ACID × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6；289 K；20% iso-propanol, 3% (w/v) PEG 4000, 0.05M MES-NaOH, pH 6.0, VAPOR DIFFUSION, HANGING DROP, temperature 289K
Resolution 1.75 Å R-free 0.224
2D7C Crystal structure of human Rab11 in complex with FIP3 Rab-binding domain Deposited 2005-11-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain D 715–756（42 aa） Fragment：Rab-binding domain
Non-standard monomer：Yes (specific site not provided by mmCIF) MG MAGNESIUM ION × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6；289 K；20% iso-propanol, 3% (w/v) PEG 4000, 0.05M MES-NaOH, pH 6.0, VAPOR DIFFUSION, HANGING DROP, temperature 289K
Resolution 1.75 Å R-free 0.224
2HV8 Crystal structure of GTP-bound Rab11 in complex with FIP3 Deposited 2006-07-27 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain D 695–756（62 aa） Fragment：C-terminal region
Not recorded MG MAGNESIUM ION × 2 SO4 SULFATE ION × 2 GTP GUANOSINE-5'-TRIPHOSPHATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；20% PEG4000, 0.4M Ammonium Sulfate, 100mM MES, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
Resolution 1.86 Å R-free 0.237
2HV8 Crystal structure of GTP-bound Rab11 in complex with FIP3 Deposited 2006-07-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain E 695–756（62 aa） Fragment：C-terminal region
Chain F 695–756（62 aa） Fragment：C-terminal region
Not recorded MG MAGNESIUM ION × 2 SO4 SULFATE ION × 4 GTP GUANOSINE-5'-TRIPHOSPHATE × 2 2ME METHOXYETHANE × 1 MES 2-(N-MORPHOLINO)-ETHANESULFONIC ACID × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；20% PEG4000, 0.4M Ammonium Sulfate, 100mM MES, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
Resolution 1.86 Å R-free 0.237
4D0M Phosphatidylinositol 4-kinase III beta in a complex with Rab11a-GTP- gamma-S and the Rab-binding domain of FIP3 Deposited 2014-04-29 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 12 PDB declaration: dodecameric
Chain E 713–756（44 aa） Fragment：RAB-BINDING DOMAIN
Chain F 713–756（44 aa） Fragment：RAB-BINDING DOMAIN
Chain U 713–756（44 aa） Fragment：RAB-BINDING DOMAIN
Chain V 713–756（44 aa） Fragment：RAB-BINDING DOMAIN
Mutation：YES Mutation：YES Mutation：YES Mutation：YES 093 N-(5-(4-CHLORO-3-(2-HYDROXY-ETHYLSULFAMOYL)- PHENYLTHIAZOLE-2-YL)-ACETAMIDE × 4 GSP 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE × 4 MG MAGNESIUM ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions 16% PEG 6K, 0.01 M NA CITRATE
Resolution 6.00 Å R-free 0.359
4D0M Phosphatidylinositol 4-kinase III beta in a complex with Rab11a-GTP- gamma-S and the Rab-binding domain of FIP3 Deposited 2014-04-29 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 12 PDB declaration: dodecameric
Chain K 713–756（44 aa） Fragment：RAB-BINDING DOMAIN
Chain L 713–756（44 aa） Fragment：RAB-BINDING DOMAIN
Chain e 713–756（44 aa） Fragment：RAB-BINDING DOMAIN
Chain f 713–756（44 aa） Fragment：RAB-BINDING DOMAIN
Mutation：YES Mutation：YES Mutation：YES Mutation：YES 093 N-(5-(4-CHLORO-3-(2-HYDROXY-ETHYLSULFAMOYL)- PHENYLTHIAZOLE-2-YL)-ACETAMIDE × 4 GSP 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE × 4 MG MAGNESIUM ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions 16% PEG 6K, 0.01 M NA CITRATE
Resolution 6.00 Å R-free 0.359
4D0M Phosphatidylinositol 4-kinase III beta in a complex with Rab11a-GTP- gamma-S and the Rab-binding domain of FIP3 Deposited 2014-04-29 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 12 PDB declaration: dodecameric
Chain a 713–756（44 aa） Fragment：RAB-BINDING DOMAIN
Chain b 713–756（44 aa） Fragment：RAB-BINDING DOMAIN
Chain i 713–756（44 aa） Fragment：RAB-BINDING DOMAIN
Chain j 713–756（44 aa） Fragment：RAB-BINDING DOMAIN
Mutation：YES Mutation：YES Mutation：YES Mutation：YES 093 N-(5-(4-CHLORO-3-(2-HYDROXY-ETHYLSULFAMOYL)- PHENYLTHIAZOLE-2-YL)-ACETAMIDE × 4 GSP 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE × 4 MG MAGNESIUM ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions 16% PEG 6K, 0.01 M NA CITRATE
Resolution 6.00 Å R-free 0.359
4UJ4 Crystal structure of human Rab11-Rabin8-FIP3 Deposited 2015-04-08 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric
Chain F 695–756（62 aa） Fragment：C-TERMINAL DOMAIN, RESIDUES 695-756
Chain I 695–756（62 aa） Fragment：C-TERMINAL DOMAIN, RESIDUES 695-756
Not recorded GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 2 MG MAGNESIUM ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 5.8；50MM MES PH 5.8, 0.2M AMMONIUM SULFATE AND 14% PEG 8000
Resolution 4.20 Å R-free 0.266
4UJ4 Crystal structure of human Rab11-Rabin8-FIP3 Deposited 2015-04-08 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric
Chain C 695–756（62 aa） Fragment：C-TERMINAL DOMAIN, RESIDUES 695-756
Chain L 695–756（62 aa） Fragment：C-TERMINAL DOMAIN, RESIDUES 695-756
Not recorded GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 2 MG MAGNESIUM ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 5.8；50MM MES PH 5.8, 0.2M AMMONIUM SULFATE AND 14% PEG 8000
Resolution 4.20 Å R-free 0.266
4UJ4 Crystal structure of human Rab11-Rabin8-FIP3 Deposited 2015-04-08 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric
Chain C 695–756（62 aa） Fragment：C-TERMINAL DOMAIN, RESIDUES 695-756
Chain L 695–756（62 aa） Fragment：C-TERMINAL DOMAIN, RESIDUES 695-756
Not recorded GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 2 MG MAGNESIUM ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 5.8；50MM MES PH 5.8, 0.2M AMMONIUM SULFATE AND 14% PEG 8000
Resolution 4.20 Å R-free 0.266

4 other PDB entries and 10 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name RFIP3_HUMAN
Isoform —
PDB entities 3
Chains and sequence ranges Author chain C； PDBConstruct 5–66； UniProt 695–756 Author chain F； PDBConstruct 5–66； UniProt 695–756 Author chain I； PDBConstruct 5–66； UniProt 695–756 Author chain L； PDBConstruct 5–66； UniProt 695–756 Author chain O； PDBConstruct 5–66； UniProt 695–756 Author chain R； PDBConstruct 5–66； UniProt 695–756 Author chain U； PDBConstruct 5–66； UniProt 695–756 Author chain X； PDBConstruct 5–66； UniProt 695–756

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

SAXS scattering curve SAXS Profile

SAXS profile for 4uj3

P(r) Distance Distribution P(r) Distribution

P(r) distribution for 4uj3
Download Download
▼

2. Structure Basics 2. Structure Basics

Entry ID entry_id4uj3
Deposition date deposition_date2015-04-08
Structure title titleCrystal structure of human Rab11-Rabin8-FIP3
Keywords keywordsTRANSPORT PROTEIN, CILIARY TARGETING COMPLEX, CILIUM, VESICULAR TRANSPORT, MEMBRANE TRAFFICKING; TRANSPORT PROTEIN
Experimental Method methodX-RAY DIFFRACTION
▼

3. SAXS Parameters (CRYSOL theoretical calculation) 3. SAXS Parameters (CRYSOL)

Radius of gyration Rg (Guinier) rg_guinier58.92 Å
Radius of gyration Rg (electron density) rg_electron58.77 Å
Forward intensity I(0) i01578490000.00
Molecular weight molecular_weight330160.0 kDa
Excluded volume excluded_volume411900 ų
Envelope volume envelope_volume714070 ų
Hydration-shell volume shell_volume103310 ų
Envelope diameter envelope_diameter194.0 Å
Shell Rg shell_rg59.73 Å
Envelope Rg envelope_rg56.01 Å
Shape Rg shape_rg58.76 Å
Total Rg total_rg58.82 Å
Total atoms total_atoms23224
Residues n_residues2965
Spherical-harmonic order n_harmonics20
q range q_range— – 0.5000 Å−1
Data points n_points101
Shell type shell_typedirectional
Solvent electron density solvent_density0.3340 e/ų
Shell contrast contrast_shell0.0300 e/ų
CRYSOL version crysol_version4.1.3
▼

4. P(r) Distance Distribution (GNOM inversion) 4. P(r) Analysis (GNOM)

Maximum dimension Dmax dmax197.4 Å
Rg (real space) rg_real58.78 Å
Rg uncertainty (real space) rg_real_error2.25 Å
I(0) (real space) i0_real1.5780e+09
I(0) uncertainty (real space) i0_real_error3.5290e+07
Rg (reciprocal space) rg_reciprocal59.01 Å
I(0) (reciprocal space) i0_reciprocal1579000000.0000
Solution quality estimate total_estimate0.8828
Solution quality rating solution_quality GOOD a GOOD solution
P(r) peaks n_peaks1
Primary peak position r_peak_primary73.1 Å
Skewness Skewness skewness0.197
Kurtosis Kurtosis kurtosis-0.446
Angular range angular_range— – 0.1350 Å−1
Current regularization parameter α current_alpha0.0000
Highest regularization parameter α highest_alpha60530000.0000
Real-space data points n_real_points28
GNOM version gnom_version4.1.3
Quality Criteria quality_criteria AN1: 0.000; Oscil: 0.888; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.997; Smooth: 0.813
▶

5. Crystallography and Experiment 5. Crystallography & Experiment

▶

6. Entities and Polymers Entities & Polymers (8)

▼

7. Fold Classification (SCOP + CATH) 23 domains

SCOP 2.08 (14 domains)

Domain ID domain_idd4uj3a_
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.37 — P-loop containing nucleoside triphosphate hydrolases
Superfamily Superfamily superfamilyc.37.1 — P-loop containing nucleoside triphosphate hydrolases
Family Family familyc.37.1.0 — automated matches
Domain ID domain_idd4uj3d_
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.37 — P-loop containing nucleoside triphosphate hydrolases
Superfamily Superfamily superfamilyc.37.1 — P-loop containing nucleoside triphosphate hydrolases
Family Family familyc.37.1.0 — automated matches
Domain ID domain_idd4uj3f_
Class classh — Coiled coil proteins
Fold Fold foldh.1 — Parallel coiled-coil
Superfamily Superfamily superfamilyh.1.31 — Eferin C-derminal domain-like
Family Family familyh.1.31.1 — Eferin C-derminal domain-like
Domain ID domain_idd4uj3g_
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.37 — P-loop containing nucleoside triphosphate hydrolases
Superfamily Superfamily superfamilyc.37.1 — P-loop containing nucleoside triphosphate hydrolases
Family Family familyc.37.1.0 — automated matches
Domain ID domain_idd4uj3i_
Class classh — Coiled coil proteins
Fold Fold foldh.1 — Parallel coiled-coil
Superfamily Superfamily superfamilyh.1.31 — Eferin C-derminal domain-like
Family Family familyh.1.31.1 — Eferin C-derminal domain-like
Domain ID domain_idd4uj3j_
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.37 — P-loop containing nucleoside triphosphate hydrolases
Superfamily Superfamily superfamilyc.37.1 — P-loop containing nucleoside triphosphate hydrolases
Family Family familyc.37.1.0 — automated matches
Domain ID domain_idd4uj3l_
Class classh — Coiled coil proteins
Fold Fold foldh.1 — Parallel coiled-coil
Superfamily Superfamily superfamilyh.1.31 — Eferin C-derminal domain-like
Family Family familyh.1.31.1 — Eferin C-derminal domain-like
Domain ID domain_idd4uj3m_
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.37 — P-loop containing nucleoside triphosphate hydrolases
Superfamily Superfamily superfamilyc.37.1 — P-loop containing nucleoside triphosphate hydrolases
Family Family familyc.37.1.0 — automated matches
Domain ID domain_idd4uj3o_
Class classh — Coiled coil proteins
Fold Fold foldh.1 — Parallel coiled-coil
Superfamily Superfamily superfamilyh.1.31 — Eferin C-derminal domain-like
Family Family familyh.1.31.1 — Eferin C-derminal domain-like
Domain ID domain_idd4uj3p_
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.37 — P-loop containing nucleoside triphosphate hydrolases
Superfamily Superfamily superfamilyc.37.1 — P-loop containing nucleoside triphosphate hydrolases
Family Family familyc.37.1.0 — automated matches
Domain ID domain_idd4uj3r_
Class classh — Coiled coil proteins
Fold Fold foldh.1 — Parallel coiled-coil
Superfamily Superfamily superfamilyh.1.31 — Eferin C-derminal domain-like
Family Family familyh.1.31.1 — Eferin C-derminal domain-like
Domain ID domain_idd4uj3s_
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.37 — P-loop containing nucleoside triphosphate hydrolases
Superfamily Superfamily superfamilyc.37.1 — P-loop containing nucleoside triphosphate hydrolases
Family Family familyc.37.1.0 — automated matches
Domain ID domain_idd4uj3u_
Class classh — Coiled coil proteins
Fold Fold foldh.1 — Parallel coiled-coil
Superfamily Superfamily superfamilyh.1.31 — Eferin C-derminal domain-like
Family Family familyh.1.31.1 — Eferin C-derminal domain-like
Domain ID domain_idd4uj3v_
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.37 — P-loop containing nucleoside triphosphate hydrolases
Superfamily Superfamily superfamilyc.37.1 — P-loop containing nucleoside triphosphate hydrolases
Family Family familyc.37.1.0 — automated matches

CATH v4.4 (9 domains)

Domain ID domain_id4uj3A00
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily300 — P-loop containing nucleotide triphosphate hydrolases
Domain ID domain_id4uj3D00
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily300 — P-loop containing nucleotide triphosphate hydrolases
Domain ID domain_id4uj3G00
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily300 — P-loop containing nucleotide triphosphate hydrolases
Domain ID domain_id4uj3I00
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology5 — Single alpha-helices involved in coiled-coils or other helix-helix interfaces
Homologous superfamily homologous superfamily2440 —
Domain ID domain_id4uj3J00
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily300 — P-loop containing nucleotide triphosphate hydrolases
Domain ID domain_id4uj3M00
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily300 — P-loop containing nucleotide triphosphate hydrolases
Domain ID domain_id4uj3P00
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily300 — P-loop containing nucleotide triphosphate hydrolases
Domain ID domain_id4uj3S00
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily300 — P-loop containing nucleotide triphosphate hydrolases
Domain ID domain_id4uj3V00
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily300 — P-loop containing nucleotide triphosphate hydrolases
▶

8. Citations (1)

▶

9. Files and Curves (10)