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5ftt

Octameric complex of Latrophilin 3 (Lec, Olf) , Unc5D (Ig, Ig2, TSP1) and FLRT2 (LRR)

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

NETRIN RECEPTOR UNC5D

RATTUS NORVEGICUS

UniProt F1LW30

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 8 LEUCINE-RICH REPEAT TRANSMEMBRANE PROTEIN FLRT2 × 2 （Q8BLU0） ADHESION G PROTEIN-COUPLED RECEPTOR L3 × 4 （Q80TS3） 2-acetamido-2-deoxy-beta-D-glucopyranose × 8 SODIUM ION × 4 CALCIUM ION × 4 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
4v2b 4v2b

2 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
4v2c 4v2c 5ftt 5ftu 5ftu 5ftu 7za1 7za2 7za3

9 assemblies

View Construct and Data Evidence
UniProt name UNC5D_RAT
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–276； UniProt 32–307 Author chain E； PDBConstruct 1–276； UniProt 32–307

LEUCINE-RICH REPEAT TRANSMEMBRANE PROTEIN FLRT2

MUS MUSCULUS

UniProt Q8BLU0

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 8 NETRIN RECEPTOR UNC5D × 2 （F1LW30） ADHESION G PROTEIN-COUPLED RECEPTOR L3 × 4 （Q80TS3） 2-acetamido-2-deoxy-beta-D-glucopyranose × 8 SODIUM ION × 4 CALCIUM ION × 4 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
4v2d

1 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
4v2c 4v2c 5ftt 5ftu 5ftu 5ftu

6 assemblies

View Construct and Data Evidence
UniProt name FLRT2_MOUSE
Isoform —
PDB entities 2
Chains and sequence ranges Author chain B； PDBConstruct 3–330； UniProt 35–362 Author chain F； PDBConstruct 3–330； UniProt 35–362

ADHESION G PROTEIN-COUPLED RECEPTOR L3

MUS MUSCULUS

UniProt Q80TS3

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 8 NETRIN RECEPTOR UNC5D × 2 （F1LW30） LEUCINE-RICH REPEAT TRANSMEMBRANE PROTEIN FLRT2 × 2 （Q8BLU0） 2-acetamido-2-deoxy-beta-D-glucopyranose × 8 SODIUM ION × 4 CALCIUM ION × 4 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
4rmk 4rml

2 assemblies

Homodimer

None

Homotetramer
5afb

1 assemblies

Other homooligomers

None

Heteromeric or nucleic-acid complex
4yeb 5ftt 5ftu 5ftu 5ftu 6jbu 7wy5 7wy8 7wyb 7x10

10 assemblies

View Construct and Data Evidence
UniProt name AGRL3_MOUSE
Isoform —
PDB entities 3
Chains and sequence ranges Author chain C； PDBConstruct 3–374； UniProt 92–463 Author chain D； PDBConstruct 3–374； UniProt 92–463 Author chain G； PDBConstruct 3–374； UniProt 92–463 Author chain H； PDBConstruct 3–374； UniProt 92–463

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id5ftt
Deposition date deposition_date2016-01-15
Structure title titleOctameric complex of Latrophilin 3 (Lec, Olf) , Unc5D (Ig, Ig2, TSP1) and FLRT2 (LRR)
Keywords keywords;SIGNALING PROTEIN, SIGNALLING PROTEIN, LEUCINE-RICH REPEAT, LRR, UNC5, UNC5D, FLRT2, LPHN3, LPHN, ADGRL, ADGRL3, ADGR, GPCR, UNCOORDINATED-5, NETRIN RECEPTOR, FLRT, LATROPHILIN, ADHESION, REPULSION, GUIDANCE, BETA PROPELLER, IMMUNOGLOBULIN, THROMBOSPONDIN, OLFACTOMEDIN, LECTIN, OCTAMER ;; SIGNALING PROTEIN
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

5ftt__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

5ftt__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 109 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

5ftt__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）50.90 Å
Rg (electron density)51.01 Å
Total Rg51.19 Å
Atom count19610
Residues2436
Excluded volume346670 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 5ftt__assembly_1__model_1 octameric （8） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (6)

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6. Fold Classification (SCOP + CATH) 4 domains

CATH v4.4 (4 domains)

Domain ID domain_id5fttB00
Class class3 — Alpha Beta
Architecture architecture80 — Alpha-Beta Horseshoe
Topology topology10 — Leucine-rich repeat, LRR (right-handed beta-alpha superhelix)
Homologous superfamily homologous superfamily10 — Ribonuclease Inhibitor
Domain ID domain_id5fttC01
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology120 — Jelly Rolls
Homologous superfamily homologous superfamily740 — Rhamnose-binding lectin domain (RBL)
Domain ID domain_id5fttF00
Class class3 — Alpha Beta
Architecture architecture80 — Alpha-Beta Horseshoe
Topology topology10 — Leucine-rich repeat, LRR (right-handed beta-alpha superhelix)
Homologous superfamily homologous superfamily10 — Ribonuclease Inhibitor
Domain ID domain_id5fttG01
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology120 — Jelly Rolls
Homologous superfamily homologous superfamily740 — Rhamnose-binding lectin domain (RBL)
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7. Citations (1)