← Back to search
5iro

Crystal structure of a complex between the Human adenovirus type 4 E3-19K protein and MHC class molecule HLA-A2/TAX

Method: X-RAY DIFFRACTION
▼

1. Protein Identity and Related Structures Protein Identity & Related Structures

HLA class I histocompatibility antigen, A-2 alpha chain

Homo sapiens

UniProt P01892

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 4 TAX protein × 1 （Q80817） Beta-2-microglobulin × 1 （P61769） E3 19 kDa protein × 1 （Q8BEL5） water × 2 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 4 TAX protein × 1 （Q80817） Beta-2-microglobulin × 1 （P61769） E3 19 kDa protein × 1 （Q8BEL5） water × 2 Consistent with protein count
3 Protein heterocomplex Heteromer Protein 4 TAX protein × 1 （Q80817） Beta-2-microglobulin × 1 （P61769） E3 19 kDa protein × 1 （Q8BEL5） water × 4 Consistent with protein count
4 Protein heterocomplex Heteromer Protein 4 TAX protein × 1 （Q80817） Beta-2-microglobulin × 1 （P61769） E3 19 kDa protein × 1 （Q8BEL5） water × 3 Consistent with protein count
5 Protein heterocomplex Heteromer Protein 4 TAX protein × 1 （Q80817） Beta-2-microglobulin × 1 （P61769） E3 19 kDa protein × 1 （Q8BEL5） water × 3 Consistent with protein count
6 Protein heterocomplex Heteromer Protein 4 TAX protein × 1 （Q80817） Beta-2-microglobulin × 1 （P61769） E3 19 kDa protein × 1 （Q8BEL5） water × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1akj 1ao7 1ao7 1aqd 1aqd 1aqd 1aqd 1b0g 1b0g 1b0r 1bd2 1duy

466 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name 1A02_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–275； UniProt 25–299 Author chain E； PDBConstruct 1–275； UniProt 25–299 Author chain I； PDBConstruct 1–275； UniProt 25–299 Author chain M； PDBConstruct 1–275； UniProt 25–299 Author chain Q； PDBConstruct 1–275； UniProt 25–299 Author chain U； PDBConstruct 1–275； UniProt 25–299

TAX protein

OrganismNot specified

UniProt Q80817

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 4 HLA class I histocompatibility antigen, A-2 alpha chain × 1 （P01892） Beta-2-microglobulin × 1 （P61769） E3 19 kDa protein × 1 （Q8BEL5） water × 2 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 4 HLA class I histocompatibility antigen, A-2 alpha chain × 1 （P01892） Beta-2-microglobulin × 1 （P61769） E3 19 kDa protein × 1 （Q8BEL5） water × 2 Consistent with protein count
3 Protein heterocomplex Heteromer Protein 4 HLA class I histocompatibility antigen, A-2 alpha chain × 1 （P01892） Beta-2-microglobulin × 1 （P61769） E3 19 kDa protein × 1 （Q8BEL5） water × 4 Consistent with protein count
4 Protein heterocomplex Heteromer Protein 4 HLA class I histocompatibility antigen, A-2 alpha chain × 1 （P01892） Beta-2-microglobulin × 1 （P61769） E3 19 kDa protein × 1 （Q8BEL5） water × 3 Consistent with protein count
5 Protein heterocomplex Heteromer Protein 4 HLA class I histocompatibility antigen, A-2 alpha chain × 1 （P01892） Beta-2-microglobulin × 1 （P61769） E3 19 kDa protein × 1 （Q8BEL5） water × 3 Consistent with protein count
6 Protein heterocomplex Heteromer Protein 4 HLA class I histocompatibility antigen, A-2 alpha chain × 1 （P01892） Beta-2-microglobulin × 1 （P61769） E3 19 kDa protein × 1 （Q8BEL5） water × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
5iro 5iro 5iro 5iro 5iro 5iro 9nds 9nds

8 assemblies

View Construct and Data Evidence
UniProt name Q80817_9DELA
Isoform —
PDB entities 2
Chains and sequence ranges Author chain B； PDBConstruct 1–9； UniProt 11–19 Author chain F； PDBConstruct 1–9； UniProt 11–19 Author chain J； PDBConstruct 1–9； UniProt 11–19 Author chain N； PDBConstruct 1–9； UniProt 11–19 Author chain R； PDBConstruct 1–9； UniProt 11–19 Author chain V； PDBConstruct 1–9； UniProt 11–19

Beta-2-microglobulin

Homo sapiens

UniProt P61769

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 4 HLA class I histocompatibility antigen, A-2 alpha chain × 1 （P01892） TAX protein × 1 （Q80817） E3 19 kDa protein × 1 （Q8BEL5） water × 2 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 4 HLA class I histocompatibility antigen, A-2 alpha chain × 1 （P01892） TAX protein × 1 （Q80817） E3 19 kDa protein × 1 （Q8BEL5） water × 2 Consistent with protein count
3 Protein heterocomplex Heteromer Protein 4 HLA class I histocompatibility antigen, A-2 alpha chain × 1 （P01892） TAX protein × 1 （Q80817） E3 19 kDa protein × 1 （Q8BEL5） water × 4 Consistent with protein count
4 Protein heterocomplex Heteromer Protein 4 HLA class I histocompatibility antigen, A-2 alpha chain × 1 （P01892） TAX protein × 1 （Q80817） E3 19 kDa protein × 1 （Q8BEL5） water × 3 Consistent with protein count
5 Protein heterocomplex Heteromer Protein 4 HLA class I histocompatibility antigen, A-2 alpha chain × 1 （P01892） TAX protein × 1 （Q80817） E3 19 kDa protein × 1 （Q8BEL5） water × 3 Consistent with protein count
6 Protein heterocomplex Heteromer Protein 4 HLA class I histocompatibility antigen, A-2 alpha chain × 1 （P01892） TAX protein × 1 （Q80817） E3 19 kDa protein × 1 （Q8BEL5） water × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1jnj 1lds 1py4 1py4 1py4 1py4 2d4d 2d4f 2vb5 2xks 2xku 2yxf

61 assemblies; showing the first 12

Homodimer
2x89 2x89 2z9t 3low 4r9h 4r9h 4ra3 4ra3 4rah 6m1b

10 assemblies

Homotetramer
2e8d 2f8o 3tlr 3tm6 3tm6 7afv

6 assemblies

Other homooligomers
3ciq 3ciq 3loz 6gk3 8a7o 8a7p 8a7q 8a7t

8 assemblies

Heteromeric or nucleic-acid complex
1a1m 1a1n 1a1o 1a6z 1a6z 1a9b 1a9b 1a9e 1agb 1agc 1agd 1age

1914 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name B2MG_HUMAN
Isoform —
PDB entities 3
Chains and sequence ranges Author chain C； PDBConstruct 2–100； UniProt 21–119 Author chain G； PDBConstruct 2–100； UniProt 21–119 Author chain K； PDBConstruct 2–100； UniProt 21–119 Author chain O； PDBConstruct 2–100； UniProt 21–119 Author chain S； PDBConstruct 2–100； UniProt 21–119 Author chain W； PDBConstruct 2–100； UniProt 21–119

E3 19 kDa protein

Human adenovirus E serotype 4

UniProt Q8BEL5

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 4 HLA class I histocompatibility antigen, A-2 alpha chain × 1 （P01892） TAX protein × 1 （Q80817） Beta-2-microglobulin × 1 （P61769） water × 2 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 4 HLA class I histocompatibility antigen, A-2 alpha chain × 1 （P01892） TAX protein × 1 （Q80817） Beta-2-microglobulin × 1 （P61769） water × 2 Consistent with protein count
3 Protein heterocomplex Heteromer Protein 4 HLA class I histocompatibility antigen, A-2 alpha chain × 1 （P01892） TAX protein × 1 （Q80817） Beta-2-microglobulin × 1 （P61769） water × 4 Consistent with protein count
4 Protein heterocomplex Heteromer Protein 4 HLA class I histocompatibility antigen, A-2 alpha chain × 1 （P01892） TAX protein × 1 （Q80817） Beta-2-microglobulin × 1 （P61769） water × 3 Consistent with protein count
5 Protein heterocomplex Heteromer Protein 4 HLA class I histocompatibility antigen, A-2 alpha chain × 1 （P01892） TAX protein × 1 （Q80817） Beta-2-microglobulin × 1 （P61769） water × 3 Consistent with protein count
6 Protein heterocomplex Heteromer Protein 4 HLA class I histocompatibility antigen, A-2 alpha chain × 1 （P01892） TAX protein × 1 （Q80817） Beta-2-microglobulin × 1 （P61769） water × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
5iro 5iro 5iro 5iro 5iro 5iro

6 assemblies

View Construct and Data Evidence
UniProt name Q8BEL5_ADE04
Isoform —
PDB entities 4
Chains and sequence ranges Author chain D； PDBConstruct 1–108； UniProt 24–131 Author chain H； PDBConstruct 1–108； UniProt 24–131 Author chain L； PDBConstruct 1–108； UniProt 24–131 Author chain P； PDBConstruct 1–108； UniProt 24–131 Author chain T； PDBConstruct 1–108； UniProt 24–131 Author chain X； PDBConstruct 1–108； UniProt 24–131

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

▼

2. Structure Basics 2. Structure Basics

Entry ID entry_id5iro
Deposition date deposition_date2016-03-14
Structure title titleCrystal structure of a complex between the Human adenovirus type 4 E3-19K protein and MHC class molecule HLA-A2/TAX
Keywords keywordsAd4 E3-19K-HLA-A2 COMPLEX, IMMUNE EVASION FUNCTION, MHC CLASS I MOLECULE, Immune system-transcription complex; Immune system/transcription
Experimental Method methodX-RAY DIFFRACTION
▼

3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

5iro__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

5iro__assembly_1__model_1 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

5iro__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）25.88 Å
Rg (electron density)24.79 Å
Total Rg25.66 Å
Atom count3845
Residues471
Excluded volume67358 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 5iro__assembly_1__model_1 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 5iro__assembly_2__model_1 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
3 1 5iro__assembly_3__model_1 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
4 1 5iro__assembly_4__model_1 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
5 1 5iro__assembly_5__model_1 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
6 1 5iro__assembly_6__model_1 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
▶

4. Crystallography and Experiment 4. Crystallography & Experiment

▶

5. Entities and Polymers Entities & Polymers (5)

▼

6. Fold Classification (SCOP + CATH) 24 domains

CATH v4.4 (24 domains)

Domain ID domain_id5iroA01
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology500 — Murine Class I Major Histocompatibility Complex, H2-DB; Chain A, domain 1
Homologous superfamily homologous superfamily10 — MHC class I-like antigen recognition-like
Domain ID domain_id5iroA02
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology40 — Immunoglobulin-like
Homologous superfamily homologous superfamily10 — Immunoglobulins
Domain ID domain_id5iroC00
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology40 — Immunoglobulin-like
Homologous superfamily homologous superfamily10 — Immunoglobulins
Domain ID domain_id5iroD00
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology40 — Immunoglobulin-like
Homologous superfamily homologous superfamily3530 —
Domain ID domain_id5iroE01
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology500 — Murine Class I Major Histocompatibility Complex, H2-DB; Chain A, domain 1
Homologous superfamily homologous superfamily10 — MHC class I-like antigen recognition-like
Domain ID domain_id5iroE02
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology40 — Immunoglobulin-like
Homologous superfamily homologous superfamily10 — Immunoglobulins
Domain ID domain_id5iroG00
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology40 — Immunoglobulin-like
Homologous superfamily homologous superfamily10 — Immunoglobulins
Domain ID domain_id5iroH00
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology40 — Immunoglobulin-like
Homologous superfamily homologous superfamily3530 —
Domain ID domain_id5iroI01
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology500 — Murine Class I Major Histocompatibility Complex, H2-DB; Chain A, domain 1
Homologous superfamily homologous superfamily10 — MHC class I-like antigen recognition-like
Domain ID domain_id5iroI02
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology40 — Immunoglobulin-like
Homologous superfamily homologous superfamily10 — Immunoglobulins
Domain ID domain_id5iroK00
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology40 — Immunoglobulin-like
Homologous superfamily homologous superfamily10 — Immunoglobulins
Domain ID domain_id5iroL00
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology40 — Immunoglobulin-like
Homologous superfamily homologous superfamily3530 —
Domain ID domain_id5iroM01
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology500 — Murine Class I Major Histocompatibility Complex, H2-DB; Chain A, domain 1
Homologous superfamily homologous superfamily10 — MHC class I-like antigen recognition-like
Domain ID domain_id5iroM02
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology40 — Immunoglobulin-like
Homologous superfamily homologous superfamily10 — Immunoglobulins
Domain ID domain_id5iroO00
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology40 — Immunoglobulin-like
Homologous superfamily homologous superfamily10 — Immunoglobulins
Domain ID domain_id5iroP00
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology40 — Immunoglobulin-like
Homologous superfamily homologous superfamily3530 —
Domain ID domain_id5iroQ01
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology500 — Murine Class I Major Histocompatibility Complex, H2-DB; Chain A, domain 1
Homologous superfamily homologous superfamily10 — MHC class I-like antigen recognition-like
Domain ID domain_id5iroQ02
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology40 — Immunoglobulin-like
Homologous superfamily homologous superfamily10 — Immunoglobulins
Domain ID domain_id5iroS00
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology40 — Immunoglobulin-like
Homologous superfamily homologous superfamily10 — Immunoglobulins
Domain ID domain_id5iroT00
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology40 — Immunoglobulin-like
Homologous superfamily homologous superfamily3530 —
Domain ID domain_id5iroU01
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology500 — Murine Class I Major Histocompatibility Complex, H2-DB; Chain A, domain 1
Homologous superfamily homologous superfamily10 — MHC class I-like antigen recognition-like
Domain ID domain_id5iroU02
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology40 — Immunoglobulin-like
Homologous superfamily homologous superfamily10 — Immunoglobulins
Domain ID domain_id5iroW00
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology40 — Immunoglobulin-like
Homologous superfamily homologous superfamily10 — Immunoglobulins
Domain ID domain_id5iroX00
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology40 — Immunoglobulin-like
Homologous superfamily homologous superfamily3530 —
▶

7. Citations (1)