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5k97

Flap endonuclease 1 (FEN1) D233N with cleaved product fragment and Sm3+

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Flap endonuclease 1

Homo sapiens

UniProt P39748

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–DNA Monomer Protein 1 DNA 4 ;DNA (5'-D(*AP*CP*TP*CP*TP*GP*CP*CP*TP*CP*AP*AP*GP*AP*CP*GP*GP*T)-3') ; × 1 ;DNA (5'-D(P*TP*GP*AP*GP*GP*CP*AP*GP*AP*GP*T)-3') ; × 1 ;DNA (5'-D(*AP*CP*CP*GP*TP*CP*C)-3') ; × 1 ;DNA (5'-D(P*TP*T)-3') ; × 1 SAMARIUM (III) ION × 8 POTASSIUM ION × 1 1,2-ETHANEDIOL × 1 water × 5 Consistent with all polymers

Other States of the Same Protein in the Database

Monomer
5fv7 5fv7 5zod 9rci 9rci 9rdi 9rdi

7 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1u7b 1ul1 3q8k 3q8l 3q8m 3q8m 3uvu 5k97 5kse 5um9 5zoe 5zof

24 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name FEN1_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–335； UniProt 2–336

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id5k97
Deposition date deposition_date2016-05-31
Structure title titleFlap endonuclease 1 (FEN1) D233N with cleaved product fragment and Sm3+
Keywords keywords;METALLOPROTEIN, REPLICATION, DNA DAMAGE, DNA REPAIR, BASE EXCISION REPAIR, PROTEIN-DNA, 5' NUCLEASE, FEN, PRODUCT, HYDROLASE-DNA complex ;; HYDROLASE/DNA
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

5k97__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

5k97__assembly_1__model_1 | I(q)

10-2 10-1 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

5k97__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）24.06 Å
Rg (electron density)23.13 Å
Total Rg23.77 Å
Atom count6652
Residues379
Excluded volume60082 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 5k97__assembly_1__model_1 pentameric （5） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (9)

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6. Fold Classification (SCOP + CATH) 2 domains

CATH v4.4 (2 domains)

Domain ID domain_id5k97A01
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily1010 — 5'-nuclease
Domain ID domain_id5k97A02
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology150 — DNA polymerase; domain 1
Homologous superfamily homologous superfamily20 — 5' to 3' exonuclease, C-terminal subdomain
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7. Citations (1)