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1ul1

Crystal structure of the human FEN1-PCNA complex

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Flap endonuclease-1

Homo sapiens

UniProt P39748

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 6 Proliferating cell nuclear antigen × 3 （P12004） MAGNESIUM ION × 4 water × 1 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
5fv7 5fv7 5zod 9rci 9rci 9rdi 9rdi

7 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1u7b 1ul1 3q8k 3q8l 3q8m 3q8m 3uvu 5k97 5kse 5um9 5zoe 5zof

24 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name FEN1_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain X； PDBConstruct 1–379； UniProt 2–380 Author chain Y； PDBConstruct 1–379； UniProt 2–380 Author chain Z； PDBConstruct 1–379； UniProt 2–380

Proliferating cell nuclear antigen

Homo sapiens

UniProt P12004

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 6 Flap endonuclease-1 × 3 （P39748） MAGNESIUM ION × 4 water × 1 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
8e84 8e84 8e84

3 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers
1vym 1w60 1w60 3ja9 3vkx 3wgw 3wgw 5e0t 5e0t 5mlo 5mlw 5mom

21 assemblies; showing the first 12

Heteromeric or nucleic-acid complex
1axc 1u76 1u7b 1ul1 1vyj 1vyj 2zvk 2zvl 2zvl 2zvm 3p87 3p87

103 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name PCNA_HUMAN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain A； PDBConstruct 1–261； UniProt 1–261 Author chain B； PDBConstruct 1–261； UniProt 1–261 Author chain C； PDBConstruct 1–261； UniProt 1–261

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id1ul1
Deposition date deposition_date2003-09-05
Structure title titleCrystal structure of the human FEN1-PCNA complex
Keywords keywords;protein complex, DNA-binding protein, Flap DNA, Flap endonuclease, sliding clamp, DNA clamp, replication, DNA repair, HYDROLASE-DNA BINDING PROTEIN COMPLEX ;; HYDROLASE/DNA BINDING PROTEIN
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

1ul1__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

1ul1__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

1ul1__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）48.39 Å
Rg (electron density)47.82 Å
Total Rg47.83 Å
Atom count13161
Residues1743
Excluded volume234140 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 1ul1__assembly_1__model_1 hexameric （6） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (4)

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6. Fold Classification (SCOP + CATH) 15 domains

SCOP 2.08 (12 domains)

Domain ID domain_idd1ul1a1
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.131 — DNA clamp
Superfamily Superfamily superfamilyd.131.1 — DNA clamp
Family Family familyd.131.1.2 — DNA polymerase processivity factor
Domain ID domain_idd1ul1a2
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.131 — DNA clamp
Superfamily Superfamily superfamilyd.131.1 — DNA clamp
Family Family familyd.131.1.2 — DNA polymerase processivity factor
Domain ID domain_idd1ul1b1
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.131 — DNA clamp
Superfamily Superfamily superfamilyd.131.1 — DNA clamp
Family Family familyd.131.1.2 — DNA polymerase processivity factor
Domain ID domain_idd1ul1b2
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.131 — DNA clamp
Superfamily Superfamily superfamilyd.131.1 — DNA clamp
Family Family familyd.131.1.2 — DNA polymerase processivity factor
Domain ID domain_idd1ul1c1
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.131 — DNA clamp
Superfamily Superfamily superfamilyd.131.1 — DNA clamp
Family Family familyd.131.1.2 — DNA polymerase processivity factor
Domain ID domain_idd1ul1c2
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.131 — DNA clamp
Superfamily Superfamily superfamilyd.131.1 — DNA clamp
Family Family familyd.131.1.2 — DNA polymerase processivity factor
Domain ID domain_idd1ul1x1
Class classa — All alpha proteins
Fold Fold folda.60 — SAM domain-like
Superfamily Superfamily superfamilya.60.7 — 5' to 3' exonuclease, C-terminal subdomain
Family Family familya.60.7.1 — 5' to 3' exonuclease, C-terminal subdomain
Domain ID domain_idd1ul1x2
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.120 — PIN domain-like
Superfamily Superfamily superfamilyc.120.1 — PIN domain-like
Family Family familyc.120.1.2 — 5' to 3' exonuclease catalytic domain
Domain ID domain_idd1ul1y1
Class classa — All alpha proteins
Fold Fold folda.60 — SAM domain-like
Superfamily Superfamily superfamilya.60.7 — 5' to 3' exonuclease, C-terminal subdomain
Family Family familya.60.7.1 — 5' to 3' exonuclease, C-terminal subdomain
Domain ID domain_idd1ul1y2
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.120 — PIN domain-like
Superfamily Superfamily superfamilyc.120.1 — PIN domain-like
Family Family familyc.120.1.2 — 5' to 3' exonuclease catalytic domain
Domain ID domain_idd1ul1z1
Class classa — All alpha proteins
Fold Fold folda.60 — SAM domain-like
Superfamily Superfamily superfamilya.60.7 — 5' to 3' exonuclease, C-terminal subdomain
Family Family familya.60.7.1 — 5' to 3' exonuclease, C-terminal subdomain
Domain ID domain_idd1ul1z2
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.120 — PIN domain-like
Superfamily Superfamily superfamilyc.120.1 — PIN domain-like
Family Family familyc.120.1.2 — 5' to 3' exonuclease catalytic domain

CATH v4.4 (3 domains)

Domain ID domain_id1ul1A00
Class class3 — Alpha Beta
Architecture architecture70 — Box
Topology topology10 — Proliferating Cell Nuclear Antigen
Homologous superfamily homologous superfamily10 —
Domain ID domain_id1ul1B00
Class class3 — Alpha Beta
Architecture architecture70 — Box
Topology topology10 — Proliferating Cell Nuclear Antigen
Homologous superfamily homologous superfamily10 —
Domain ID domain_id1ul1C00
Class class3 — Alpha Beta
Architecture architecture70 — Box
Topology topology10 — Proliferating Cell Nuclear Antigen
Homologous superfamily homologous superfamily10 —
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7. Citations (1)