Structure of mammalian respiratory Complex I, class2

NADH-ubiquinone oxidoreductase chain 3

物种未注明

UniProt P03898

当前结构中的状态

Assembly	聚集状态	构建体	突变与修饰	配体、离子与共同组分	实验方法与环境	结构质量
1	蛋白异源复合物 异源复合物 蛋白 × 45 PDB 声明：45-meric（45） 与蛋白拷贝数一致	链 A； UniProt 2–112	未记录	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial × 1 （P42026） NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial × 1 （P23709） NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial × 1 （P17694） NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial × 1 （P04394） NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial × 1 （P25708） ;NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, NDUFS1 ; × 1 （P15690） NADH-ubiquinone oxidoreductase chain 1 × 1 （P03887） NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial × 1 （P42028） NADH-ubiquinone oxidoreductase chain 6 × 1 （P03924） NADH-ubiquinone oxidoreductase chain 4L × 1 （P03902） NADH-ubiquinone oxidoreductase chain 5 × 1 （P03920） NADH-ubiquinone oxidoreductase chain 4 × 1 （P03910） NADH-ubiquinone oxidoreductase chain 2 × 1 （P03892） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, NDUFA10,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial ; × 1 （P34942） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial × 1 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial × 1 ;NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial ; × 1 （P23934） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 × 1 （Q02370） Acyl carrier protein, mitochondrial × 1 （P52505） Acyl carrier protein, mitochondrial × 1 （P52505） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 × 1 （P23935） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 × 1 （Q02366） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 ; × 1 （P42029） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 × 1 （Q8HXG6） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 ; × 1 （Q95KV7） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 × 1 （Q02377） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 ; × 1 （Q02371） NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial × 1 （Q02376） ;NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2 ; × 1 （Q02827） NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 × 1 （Q02379） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 × 1 （Q02378） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial × 1 （Q8HXG5） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial ; × 1 （Q02380） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 ; × 1 （Q02367） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, NDUFB2 × 1 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3, NDUFB3 × 1 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, NDUFB8 × 1 ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 ; × 1 （P48305） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 ; × 1 （Q02369） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 × 1 （Q02368） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10, NDUFB10,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10, NDUFB10 ; × 1 （Q02373） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 × 1 （O97725） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7, NDUFA7 × 1 NADH dehydrogenase [ubiquinone] flavoprotein 3, NDUFV3 × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液：pH 8 cryo-EM玻璃化条件：冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 4.35 Å

数据库中的同蛋白其他状态

以下每一行都是同一 UniProt 蛋白在另一个 PDB 条目中的 biological assembly， “相对当前条目”直接指出证据层面的不同；没有差异标签表示当前已读取字段一致。

其他 PDB	相对当前条目 5LC5	Assembly / 聚集状态	构建体	突变与修饰	配体、离子与非聚合物	实验方法与环境	结构质量
5LDW Structure of mammalian respiratory Complex I, class1 提交 2016-06-28	构建体不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 A 1–115（115 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8；20 mM TRIS-HCL, 150 mM NaCl, 0.03% CYMAL-7 cryo-EM玻璃化条件 冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus present in a cold room, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 4.27 Å
5LDX Structure of mammalian respiratory Complex I, class3. 提交 2016-06-28	构建体不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 A 1–115（115 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 20 mM TRIS-HCL, 150 mM NaCl, 0.03% CYMAL-7；pH 8 cryo-EM玻璃化条件 冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 5.60 Å
5O31 Mitochondrial complex I in the deactive state 提交 2017-05-23	构建体不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 A 1–115（115 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.55 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.13 Å
7DGQ Activity optimized supercomplex state1 提交 2020-11-12	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 3 1–115（115 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 CU COPPER (II) ION × 3 HEA HEME-A × 2 MG MAGNESIUM ION × 1 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 UQ2 UBIQUINONE-2 × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 5.00 Å
7DGR Activity optimized supercomplex state2 提交 2020-11-12	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 3 1–115（115 aa）	未记录	FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 3 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.60 Å
7DGS Activity optimized supercomplex state3 提交 2020-11-12	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 3 1–115（115 aa）	未记录	FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 7.80 Å
7DGZ Activity optimized complex I (closed form) 提交 2020-11-12	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 3 1–115（115 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 2 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 3.80 Å
7DH0 Activity optimized complex I (open form) 提交 2020-11-12	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 3 1–115（115 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.20 Å
7DKF Activity optimized supercomplex state4 提交 2020-11-24	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 32 1–115（115 aa）	未记录	HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 8.30 Å

共 9 个其他 PDB 条目、9 个 assembly。 打开独立比较页并筛选聚集状态

查看构建体与数据证据

UniProt名称	NU3M_BOVIN
Isoform	—
PDB实体	1
链与序列区间	作者链 A； PDB构建体 1–111； UniProt 2–112

NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

物种未注明

UniProt P42026

当前结构中的状态

Assembly	聚集状态	构建体	突变与修饰	配体、离子与共同组分	实验方法与环境	结构质量
1	蛋白异源复合物 异源复合物 蛋白 × 45 PDB 声明：45-meric（45） 与蛋白拷贝数一致	链 B； UniProt 64–210	未记录	NADH-ubiquinone oxidoreductase chain 3 × 1 （P03898） NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial × 1 （P23709） NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial × 1 （P17694） NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial × 1 （P04394） NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial × 1 （P25708） ;NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, NDUFS1 ; × 1 （P15690） NADH-ubiquinone oxidoreductase chain 1 × 1 （P03887） NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial × 1 （P42028） NADH-ubiquinone oxidoreductase chain 6 × 1 （P03924） NADH-ubiquinone oxidoreductase chain 4L × 1 （P03902） NADH-ubiquinone oxidoreductase chain 5 × 1 （P03920） NADH-ubiquinone oxidoreductase chain 4 × 1 （P03910） NADH-ubiquinone oxidoreductase chain 2 × 1 （P03892） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, NDUFA10,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial ; × 1 （P34942） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial × 1 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial × 1 ;NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial ; × 1 （P23934） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 × 1 （Q02370） Acyl carrier protein, mitochondrial × 1 （P52505） Acyl carrier protein, mitochondrial × 1 （P52505） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 × 1 （P23935） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 × 1 （Q02366） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 ; × 1 （P42029） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 × 1 （Q8HXG6） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 ; × 1 （Q95KV7） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 × 1 （Q02377） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 ; × 1 （Q02371） NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial × 1 （Q02376） ;NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2 ; × 1 （Q02827） NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 × 1 （Q02379） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 × 1 （Q02378） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial × 1 （Q8HXG5） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial ; × 1 （Q02380） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 ; × 1 （Q02367） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, NDUFB2 × 1 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3, NDUFB3 × 1 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, NDUFB8 × 1 ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 ; × 1 （P48305） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 ; × 1 （Q02369） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 × 1 （Q02368） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10, NDUFB10,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10, NDUFB10 ; × 1 （Q02373） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 × 1 （O97725） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7, NDUFA7 × 1 NADH dehydrogenase [ubiquinone] flavoprotein 3, NDUFV3 × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液：pH 8 cryo-EM玻璃化条件：冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 4.35 Å

数据库中的同蛋白其他状态

以下每一行都是同一 UniProt 蛋白在另一个 PDB 条目中的 biological assembly， “相对当前条目”直接指出证据层面的不同；没有差异标签表示当前已读取字段一致。

其他 PDB	相对当前条目 5LC5	Assembly / 聚集状态	构建体	突变与修饰	配体、离子与非聚合物	实验方法与环境	结构质量
5LDW Structure of mammalian respiratory Complex I, class1 提交 2016-06-28	构建体不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 B 38–216（179 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8；20 mM TRIS-HCL, 150 mM NaCl, 0.03% CYMAL-7 cryo-EM玻璃化条件 冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus present in a cold room, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 4.27 Å
5LDX Structure of mammalian respiratory Complex I, class3. 提交 2016-06-28	构建体不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 B 38–216（179 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 20 mM TRIS-HCL, 150 mM NaCl, 0.03% CYMAL-7；pH 8 cryo-EM玻璃化条件 冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 5.60 Å
5O31 Mitochondrial complex I in the deactive state 提交 2017-05-23	构建体不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 B 38–216（179 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.55 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.13 Å
7DGQ Activity optimized supercomplex state1 提交 2020-11-12	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 D 38–216（179 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 CU COPPER (II) ION × 3 HEA HEME-A × 2 MG MAGNESIUM ION × 1 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 UQ2 UBIQUINONE-2 × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 5.00 Å
7DGR Activity optimized supercomplex state2 提交 2020-11-12	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 D 38–216（179 aa）	未记录	FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 3 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.60 Å
7DGS Activity optimized supercomplex state3 提交 2020-11-12	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 D 38–216（179 aa）	未记录	FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 7.80 Å
7DGZ Activity optimized complex I (closed form) 提交 2020-11-12	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 D 38–216（179 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 2 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 3.80 Å
7DH0 Activity optimized complex I (open form) 提交 2020-11-12	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 D 38–216（179 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.20 Å
7DKF Activity optimized supercomplex state4 提交 2020-11-24	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 D2 38–216（179 aa）	未记录	HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 8.30 Å
7QSD Bovine complex I in the active state at 3.1 A 提交 2022-01-13	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 B 1–216（216 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 13 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 CDL CARDIOLIPIN × 4 LMT DODECYL-BETA-D-MALTOSIDE × 3 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 3.10 Å
7QSK Bovine complex I in lipid nanodisc, Active-Q10 提交 2022-01-13	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 B 1–216（216 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 19 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.84 Å
7QSL Bovine complex I in lipid nanodisc, Active-apo 提交 2022-01-13	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 B 1–216（216 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 20 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 8 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.76 Å
7QSM Bovine complex I in lipid nanodisc, Deactive-ligand (composite) 提交 2022-01-13	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 B 1–216（216 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 GOL GLYCEROL × 1 LMT DODECYL-BETA-D-MALTOSIDE × 1 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.30 Å
7QSN Bovine complex I in lipid nanodisc, Deactive-apo 提交 2022-01-13	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 B 1–216（216 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 6 CHD CHOLIC ACID × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.81 Å
7QSO Bovine complex I in lipid nanodisc, State 3 (Slack) 提交 2022-01-13	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 B 1–216（216 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 6 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CHD CHOLIC ACID × 2 CDL CARDIOLIPIN × 6 U10 UBIQUINONE-10 × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 3.02 Å
7R41 Bovine complex I in the presence of IM1761092, active class i (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 B 1–216（216 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 16 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R42 Bovine complex I in the presence of IM1761092, active class ii (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 B 1–216（216 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 17 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R43 Bovine complex I in the presence of IM1761092, active class iii (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 B 1–216（216 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 CDL CARDIOLIPIN × 5 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R44 Bovine complex I in the presence of IM1761092, active class iv (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 B 1–216（216 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 11 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R45 Bovine complex I in the presence of IM1761092, deactive class i (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 B 1–216（216 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R46 Bovine complex I in the presence of IM1761092, deactive class ii (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 B 1–216（216 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 11 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R47 Bovine complex I in the presence of IM1761092, deactive class iii (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 B 1–216（216 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R48 Bovine complex I in the presence of IM1761092, deactive class iv (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 B 1–216（216 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 15 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 13 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4C Bovine complex I in the presence of IM1761092, deactive class v (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 B 1–216（216 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 12 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4D Bovine complex I in the presence of IM1761092, deactive class vi (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 B 1–216（216 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4F Bovine complex I in the presence of IM1761092, slack class i (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 B 1–216（216 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 7 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 3 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 CDL CARDIOLIPIN × 6 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R4G Bovine complex I in the presence of IM1761092, slack class ii (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 B 1–216（216 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 LMT DODECYL-BETA-D-MALTOSIDE × 10 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.50 Å
8Q0A Inward-facing, closed proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 B 1–216（216 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 16 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 8 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 MG MAGNESIUM ION × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0F Inward-facing, open2 proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 B 1–216（216 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 21 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0J Inward-facing, slack proteoliposome complex I at 3.8 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 B 1–216（216 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 4 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.80 Å
8Q0M Outward-facing, closed proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 B 1–216（216 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0O Outward-facing, open2 proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 B 1–216（216 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0Q Outward-facing, slack proteoliposome complex I at 3.6 A. Initially purified in DDM 提交 2023-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 B 1–216（216 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 4 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.60 Å
8Q1P Inward-facing, open2 proteoliposome complex I at 2.9 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 B 1–216（216 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.90 Å
8Q1U Inward-facing, open1 proteoliposome complex I at 3.3 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 B 1–216（216 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 15 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 5 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.30 Å
8Q1Y Outward-facing, open2 proteoliposome complex I at 2.6 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 B 1–216（216 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 ZN ZINC ION × 2 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q25 Outward-facing, open1 proteoliposome complex I at 2.8 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 B 1–216（216 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 ZN ZINC ION × 2 MG MAGNESIUM ION × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.80 Å
8Q45 Inward-facing, closed proteoliposome complex I at 2.7 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 B 1–216（216 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 16 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.70 Å
8Q46 Inward-facing, open2 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 B 1–216（216 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q47 Inward-facing, open1 proteoliposome complex I at 2.9 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 B 1–216（216 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 15 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 26 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 5 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.90 Å
8Q48 Outward-facing, closed proteoliposome complex I at 2.5 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 B 1–216（216 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 35 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.50 Å
8Q49 Outward-facing, open2 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 B 1–216（216 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CHD CHOLIC ACID × 1 ZN ZINC ION × 2 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 FVH [[(2~{R},3~{S},4~{R},5~{R})-5-[(3~{R})-3-aminocarbonylpiperidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{R},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3-oxidanyl-4-phosphonooxy-oxolan-2-yl]methyl hydrogen phosphate × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q4A Outward-facing, open1 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 B 1–216（216 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
9SMF Reduced bovine complex I in lipid nanodisc, NADH-active-Q10 提交 2025-09-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 B 1–216（216 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 20 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 8 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.51 Å
9SMG Reduced bovine complex I in lipid nanodisc, NADH-active-altQ10 提交 2025-09-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 B 1–216（216 aa）	非标准单体：是（mmCIF未提供具体位点）	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 18 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.42 Å
9SMH Reduced bovine complex I in lipid nanodisc, NADH-active-DDM 提交 2025-09-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 B 1–216（216 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 17 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 LMT DODECYL-BETA-D-MALTOSIDE × 1 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.61 Å
9SMI Reduced bovine complex I in lipid nanodisc, NADH-deactive 提交 2025-09-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 B 1–216（216 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 27 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 LMT DODECYL-BETA-D-MALTOSIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 5 CHD CHOLIC ACID × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.01 Å
9W2U Cryo-EM structure of complex I on the bovine heart submitochondrial particles, open 提交 2025-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 B 62–216（155 aa）	未记录	FME N-FORMYLMETHIONINE × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 18 CDL CARDIOLIPIN × 6 CHD CHOLIC ACID × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.60 Å
9W2V Cryo-EM structure of complex I on the bovine heart submitochondrial particles, closed 提交 2025-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 B 62–216（155 aa）	未记录	FME N-FORMYLMETHIONINE × 4 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 19 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 12 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 6 MG MAGNESIUM ION × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.80 Å

共 49 个其他 PDB 条目、49 个 assembly。 打开独立比较页并筛选聚集状态

查看构建体与数据证据

UniProt名称	NDUS7_BOVIN
Isoform	—
PDB实体	2
链与序列区间	作者链 B； PDB构建体 1–147； UniProt 64–210

NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial

物种未注明

UniProt P23709

当前结构中的状态

Assembly	聚集状态	构建体	突变与修饰	配体、离子与共同组分	实验方法与环境	结构质量
1	蛋白异源复合物 异源复合物 蛋白 × 45 PDB 声明：45-meric（45） 与蛋白拷贝数一致	链 C； UniProt 46–251	未记录	NADH-ubiquinone oxidoreductase chain 3 × 1 （P03898） NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial × 1 （P42026） NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial × 1 （P17694） NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial × 1 （P04394） NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial × 1 （P25708） ;NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, NDUFS1 ; × 1 （P15690） NADH-ubiquinone oxidoreductase chain 1 × 1 （P03887） NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial × 1 （P42028） NADH-ubiquinone oxidoreductase chain 6 × 1 （P03924） NADH-ubiquinone oxidoreductase chain 4L × 1 （P03902） NADH-ubiquinone oxidoreductase chain 5 × 1 （P03920） NADH-ubiquinone oxidoreductase chain 4 × 1 （P03910） NADH-ubiquinone oxidoreductase chain 2 × 1 （P03892） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, NDUFA10,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial ; × 1 （P34942） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial × 1 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial × 1 ;NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial ; × 1 （P23934） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 × 1 （Q02370） Acyl carrier protein, mitochondrial × 1 （P52505） Acyl carrier protein, mitochondrial × 1 （P52505） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 × 1 （P23935） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 × 1 （Q02366） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 ; × 1 （P42029） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 × 1 （Q8HXG6） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 ; × 1 （Q95KV7） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 × 1 （Q02377） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 ; × 1 （Q02371） NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial × 1 （Q02376） ;NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2 ; × 1 （Q02827） NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 × 1 （Q02379） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 × 1 （Q02378） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial × 1 （Q8HXG5） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial ; × 1 （Q02380） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 ; × 1 （Q02367） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, NDUFB2 × 1 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3, NDUFB3 × 1 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, NDUFB8 × 1 ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 ; × 1 （P48305） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 ; × 1 （Q02369） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 × 1 （Q02368） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10, NDUFB10,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10, NDUFB10 ; × 1 （Q02373） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 × 1 （O97725） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7, NDUFA7 × 1 NADH dehydrogenase [ubiquinone] flavoprotein 3, NDUFV3 × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液：pH 8 cryo-EM玻璃化条件：冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 4.35 Å

数据库中的同蛋白其他状态

以下每一行都是同一 UniProt 蛋白在另一个 PDB 条目中的 biological assembly， “相对当前条目”直接指出证据层面的不同；没有差异标签表示当前已读取字段一致。

其他 PDB	相对当前条目 5LC5	Assembly / 聚集状态	构建体	突变与修饰	配体、离子与非聚合物	实验方法与环境	结构质量
5LDW Structure of mammalian respiratory Complex I, class1 提交 2016-06-28	构建体不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 C 39–266（228 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8；20 mM TRIS-HCL, 150 mM NaCl, 0.03% CYMAL-7 cryo-EM玻璃化条件 冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus present in a cold room, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 4.27 Å
5LDX Structure of mammalian respiratory Complex I, class3. 提交 2016-06-28	构建体不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 C 39–266（228 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 20 mM TRIS-HCL, 150 mM NaCl, 0.03% CYMAL-7；pH 8 cryo-EM玻璃化条件 冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 5.60 Å
5O31 Mitochondrial complex I in the deactive state 提交 2017-05-23	构建体不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 C 39–266（228 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.55 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.13 Å
7DGQ Activity optimized supercomplex state1 提交 2020-11-12	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 C 39–266（228 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 CU COPPER (II) ION × 3 HEA HEME-A × 2 MG MAGNESIUM ION × 1 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 UQ2 UBIQUINONE-2 × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 5.00 Å
7DGR Activity optimized supercomplex state2 提交 2020-11-12	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 C 39–266（228 aa）	未记录	FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 3 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.60 Å
7DGS Activity optimized supercomplex state3 提交 2020-11-12	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 C 39–266（228 aa）	未记录	FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 7.80 Å
7DGZ Activity optimized complex I (closed form) 提交 2020-11-12	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 C 39–266（228 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 2 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 3.80 Å
7DH0 Activity optimized complex I (open form) 提交 2020-11-12	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 C 39–266（228 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.20 Å
7DKF Activity optimized supercomplex state4 提交 2020-11-24	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 C2 39–266（228 aa）	未记录	HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 8.30 Å
7QSD Bovine complex I in the active state at 3.1 A 提交 2022-01-13	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 C 1–266（266 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 13 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 CDL CARDIOLIPIN × 4 LMT DODECYL-BETA-D-MALTOSIDE × 3 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 3.10 Å
7QSK Bovine complex I in lipid nanodisc, Active-Q10 提交 2022-01-13	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 C 1–266（266 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 19 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.84 Å
7QSL Bovine complex I in lipid nanodisc, Active-apo 提交 2022-01-13	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 C 1–266（266 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 20 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 8 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.76 Å
7QSM Bovine complex I in lipid nanodisc, Deactive-ligand (composite) 提交 2022-01-13	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 C 1–266（266 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 GOL GLYCEROL × 1 LMT DODECYL-BETA-D-MALTOSIDE × 1 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.30 Å
7QSN Bovine complex I in lipid nanodisc, Deactive-apo 提交 2022-01-13	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 C 1–266（266 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 6 CHD CHOLIC ACID × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.81 Å
7QSO Bovine complex I in lipid nanodisc, State 3 (Slack) 提交 2022-01-13	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 C 1–266（266 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 6 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CHD CHOLIC ACID × 2 CDL CARDIOLIPIN × 6 U10 UBIQUINONE-10 × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 3.02 Å
7R41 Bovine complex I in the presence of IM1761092, active class i (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 C 1–266（266 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 16 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R42 Bovine complex I in the presence of IM1761092, active class ii (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 C 1–266（266 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 17 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R43 Bovine complex I in the presence of IM1761092, active class iii (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 C 1–266（266 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 CDL CARDIOLIPIN × 5 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R44 Bovine complex I in the presence of IM1761092, active class iv (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 C 1–266（266 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 11 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R45 Bovine complex I in the presence of IM1761092, deactive class i (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 C 1–266（266 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R46 Bovine complex I in the presence of IM1761092, deactive class ii (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 C 1–266（266 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 11 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R47 Bovine complex I in the presence of IM1761092, deactive class iii (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 C 1–266（266 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R48 Bovine complex I in the presence of IM1761092, deactive class iv (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 C 1–266（266 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 15 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 13 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4C Bovine complex I in the presence of IM1761092, deactive class v (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 C 1–266（266 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 12 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4D Bovine complex I in the presence of IM1761092, deactive class vi (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 C 1–266（266 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4F Bovine complex I in the presence of IM1761092, slack class i (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 C 1–266（266 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 7 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 3 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 CDL CARDIOLIPIN × 6 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R4G Bovine complex I in the presence of IM1761092, slack class ii (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 C 1–266（266 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 LMT DODECYL-BETA-D-MALTOSIDE × 10 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.50 Å
8Q0A Inward-facing, closed proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 C 1–266（266 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 16 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 8 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 MG MAGNESIUM ION × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0F Inward-facing, open2 proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 C 1–266（266 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 21 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0J Inward-facing, slack proteoliposome complex I at 3.8 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 C 1–266（266 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 4 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.80 Å
8Q0M Outward-facing, closed proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 C 1–266（266 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0O Outward-facing, open2 proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 C 1–266（266 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0Q Outward-facing, slack proteoliposome complex I at 3.6 A. Initially purified in DDM 提交 2023-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 C 1–266（266 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 4 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.60 Å
8Q1P Inward-facing, open2 proteoliposome complex I at 2.9 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 C 1–266（266 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.90 Å
8Q1U Inward-facing, open1 proteoliposome complex I at 3.3 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 C 1–266（266 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 15 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 5 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.30 Å
8Q1Y Outward-facing, open2 proteoliposome complex I at 2.6 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 C 1–266（266 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 ZN ZINC ION × 2 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q25 Outward-facing, open1 proteoliposome complex I at 2.8 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 C 1–266（266 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 ZN ZINC ION × 2 MG MAGNESIUM ION × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.80 Å
8Q45 Inward-facing, closed proteoliposome complex I at 2.7 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 C 1–266（266 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 16 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.70 Å
8Q46 Inward-facing, open2 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 C 1–266（266 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q47 Inward-facing, open1 proteoliposome complex I at 2.9 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 C 1–266（266 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 15 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 26 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 5 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.90 Å
8Q48 Outward-facing, closed proteoliposome complex I at 2.5 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 C 1–266（266 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 35 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.50 Å
8Q49 Outward-facing, open2 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 C 1–266（266 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CHD CHOLIC ACID × 1 ZN ZINC ION × 2 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 FVH [[(2~{R},3~{S},4~{R},5~{R})-5-[(3~{R})-3-aminocarbonylpiperidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{R},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3-oxidanyl-4-phosphonooxy-oxolan-2-yl]methyl hydrogen phosphate × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q4A Outward-facing, open1 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 C 1–266（266 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
9SMF Reduced bovine complex I in lipid nanodisc, NADH-active-Q10 提交 2025-09-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 C 1–266（266 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 20 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 8 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.51 Å
9SMG Reduced bovine complex I in lipid nanodisc, NADH-active-altQ10 提交 2025-09-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 C 1–266（266 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 18 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.42 Å
9SMH Reduced bovine complex I in lipid nanodisc, NADH-active-DDM 提交 2025-09-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 C 1–266（266 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 17 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 LMT DODECYL-BETA-D-MALTOSIDE × 1 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.61 Å
9SMI Reduced bovine complex I in lipid nanodisc, NADH-deactive 提交 2025-09-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 C 1–266（266 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 27 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 LMT DODECYL-BETA-D-MALTOSIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 5 CHD CHOLIC ACID × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.01 Å
9W2U Cryo-EM structure of complex I on the bovine heart submitochondrial particles, open 提交 2025-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 C 44–252（209 aa）	未记录	FME N-FORMYLMETHIONINE × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 18 CDL CARDIOLIPIN × 6 CHD CHOLIC ACID × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.60 Å
9W2V Cryo-EM structure of complex I on the bovine heart submitochondrial particles, closed 提交 2025-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 C 44–252（209 aa）	未记录	FME N-FORMYLMETHIONINE × 4 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 19 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 12 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 6 MG MAGNESIUM ION × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.80 Å

共 49 个其他 PDB 条目、49 个 assembly。 打开独立比较页并筛选聚集状态

查看构建体与数据证据

UniProt名称	NDUS3_BOVIN
Isoform	—
PDB实体	3
链与序列区间	作者链 C； PDB构建体 1–206； UniProt 46–251

NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial

物种未注明

UniProt P17694

当前结构中的状态

Assembly	聚集状态	构建体	突变与修饰	配体、离子与共同组分	实验方法与环境	结构质量
1	蛋白异源复合物 异源复合物 蛋白 × 45 PDB 声明：45-meric（45） 与蛋白拷贝数一致	链 D； UniProt 38–463	未记录	NADH-ubiquinone oxidoreductase chain 3 × 1 （P03898） NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial × 1 （P42026） NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial × 1 （P23709） NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial × 1 （P04394） NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial × 1 （P25708） ;NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, NDUFS1 ; × 1 （P15690） NADH-ubiquinone oxidoreductase chain 1 × 1 （P03887） NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial × 1 （P42028） NADH-ubiquinone oxidoreductase chain 6 × 1 （P03924） NADH-ubiquinone oxidoreductase chain 4L × 1 （P03902） NADH-ubiquinone oxidoreductase chain 5 × 1 （P03920） NADH-ubiquinone oxidoreductase chain 4 × 1 （P03910） NADH-ubiquinone oxidoreductase chain 2 × 1 （P03892） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, NDUFA10,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial ; × 1 （P34942） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial × 1 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial × 1 ;NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial ; × 1 （P23934） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 × 1 （Q02370） Acyl carrier protein, mitochondrial × 1 （P52505） Acyl carrier protein, mitochondrial × 1 （P52505） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 × 1 （P23935） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 × 1 （Q02366） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 ; × 1 （P42029） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 × 1 （Q8HXG6） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 ; × 1 （Q95KV7） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 × 1 （Q02377） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 ; × 1 （Q02371） NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial × 1 （Q02376） ;NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2 ; × 1 （Q02827） NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 × 1 （Q02379） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 × 1 （Q02378） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial × 1 （Q8HXG5） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial ; × 1 （Q02380） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 ; × 1 （Q02367） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, NDUFB2 × 1 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3, NDUFB3 × 1 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, NDUFB8 × 1 ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 ; × 1 （P48305） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 ; × 1 （Q02369） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 × 1 （Q02368） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10, NDUFB10,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10, NDUFB10 ; × 1 （Q02373） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 × 1 （O97725） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7, NDUFA7 × 1 NADH dehydrogenase [ubiquinone] flavoprotein 3, NDUFV3 × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液：pH 8 cryo-EM玻璃化条件：冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 4.35 Å

数据库中的同蛋白其他状态

以下每一行都是同一 UniProt 蛋白在另一个 PDB 条目中的 biological assembly， “相对当前条目”直接指出证据层面的不同；没有差异标签表示当前已读取字段一致。

其他 PDB	相对当前条目 5LC5	Assembly / 聚集状态	构建体	突变与修饰	配体、离子与非聚合物	实验方法与环境	结构质量
5LDW Structure of mammalian respiratory Complex I, class1 提交 2016-06-28	构建体不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 D 35–463（429 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8；20 mM TRIS-HCL, 150 mM NaCl, 0.03% CYMAL-7 cryo-EM玻璃化条件 冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus present in a cold room, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 4.27 Å
5LDX Structure of mammalian respiratory Complex I, class3. 提交 2016-06-28	构建体不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 D 35–463（429 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 20 mM TRIS-HCL, 150 mM NaCl, 0.03% CYMAL-7；pH 8 cryo-EM玻璃化条件 冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 5.60 Å
5O31 Mitochondrial complex I in the deactive state 提交 2017-05-23	构建体不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 D 34–463（430 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.55 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.13 Å
7DGQ Activity optimized supercomplex state1 提交 2020-11-12	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 B 34–463（430 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 CU COPPER (II) ION × 3 HEA HEME-A × 2 MG MAGNESIUM ION × 1 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 UQ2 UBIQUINONE-2 × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 5.00 Å
7DGR Activity optimized supercomplex state2 提交 2020-11-12	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 B 34–463（430 aa）	未记录	FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 3 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.60 Å
7DGS Activity optimized supercomplex state3 提交 2020-11-12	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 B 34–463（430 aa）	未记录	FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 7.80 Å
7DGZ Activity optimized complex I (closed form) 提交 2020-11-12	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 B 34–463（430 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 2 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 3.80 Å
7DH0 Activity optimized complex I (open form) 提交 2020-11-12	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 B 34–463（430 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.20 Å
7DKF Activity optimized supercomplex state4 提交 2020-11-24	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 B2 34–463（430 aa）	未记录	HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 8.30 Å
7QSD Bovine complex I in the active state at 3.1 A 提交 2022-01-13	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 D 1–463（463 aa）	突变：Q129R (Q162R) 非标准单体：是（mmCIF未提供具体位点）	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 13 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 CDL CARDIOLIPIN × 4 LMT DODECYL-BETA-D-MALTOSIDE × 3 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 3.10 Å
7QSK Bovine complex I in lipid nanodisc, Active-Q10 提交 2022-01-13	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 D 1–463（463 aa）	突变：Q129R (Q162R) 非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 19 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.84 Å
7QSL Bovine complex I in lipid nanodisc, Active-apo 提交 2022-01-13	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 D 1–463（463 aa）	突变：Q129R (Q162R) 非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 20 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 8 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.76 Å
7QSM Bovine complex I in lipid nanodisc, Deactive-ligand (composite) 提交 2022-01-13	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 D 1–463（463 aa）	突变：Q129R (Q162R) 非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 GOL GLYCEROL × 1 LMT DODECYL-BETA-D-MALTOSIDE × 1 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.30 Å
7QSN Bovine complex I in lipid nanodisc, Deactive-apo 提交 2022-01-13	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 D 1–463（463 aa）	突变：Q129R (Q162R) 非标准单体：是（mmCIF未提供具体位点）	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 6 CHD CHOLIC ACID × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.81 Å
7QSO Bovine complex I in lipid nanodisc, State 3 (Slack) 提交 2022-01-13	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 D 1–463（463 aa）	突变：Q129R (Q162R) 非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 6 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CHD CHOLIC ACID × 2 CDL CARDIOLIPIN × 6 U10 UBIQUINONE-10 × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 3.02 Å
7R41 Bovine complex I in the presence of IM1761092, active class i (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 D 1–463（463 aa）	突变：Q166R 非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 16 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R42 Bovine complex I in the presence of IM1761092, active class ii (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 D 1–463（463 aa）	突变：Q166R 非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 17 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R43 Bovine complex I in the presence of IM1761092, active class iii (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 D 1–463（463 aa）	突变：Q166R 非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 CDL CARDIOLIPIN × 5 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R44 Bovine complex I in the presence of IM1761092, active class iv (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 D 1–463（463 aa）	突变：Q166R 非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 11 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R45 Bovine complex I in the presence of IM1761092, deactive class i (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 D 1–463（463 aa）	突变：Q166R 非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R46 Bovine complex I in the presence of IM1761092, deactive class ii (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 D 1–463（463 aa）	突变：Q166R 非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 11 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R47 Bovine complex I in the presence of IM1761092, deactive class iii (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 D 1–463（463 aa）	突变：Q166R 非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R48 Bovine complex I in the presence of IM1761092, deactive class iv (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 D 1–463（463 aa）	突变：Q166R 非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 15 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 13 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4C Bovine complex I in the presence of IM1761092, deactive class v (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 D 1–463（463 aa）	突变：Q166R 非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 12 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4D Bovine complex I in the presence of IM1761092, deactive class vi (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 D 1–463（463 aa）	突变：Q166R 非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4F Bovine complex I in the presence of IM1761092, slack class i (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 D 1–463（463 aa）	非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 7 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 3 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 CDL CARDIOLIPIN × 6 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R4G Bovine complex I in the presence of IM1761092, slack class ii (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 D 1–463（463 aa）	突变：Q166R 非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 LMT DODECYL-BETA-D-MALTOSIDE × 10 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.50 Å
8Q0A Inward-facing, closed proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 D 1–463（463 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 16 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 8 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 MG MAGNESIUM ION × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0F Inward-facing, open2 proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 D 1–463（463 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 21 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0J Inward-facing, slack proteoliposome complex I at 3.8 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 D 1–463（463 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 4 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.80 Å
8Q0M Outward-facing, closed proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 D 1–463（463 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0O Outward-facing, open2 proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 D 1–463（463 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0Q Outward-facing, slack proteoliposome complex I at 3.6 A. Initially purified in DDM 提交 2023-07-28	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 D 1–463（463 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 4 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.60 Å
8Q1P Inward-facing, open2 proteoliposome complex I at 2.9 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 D 1–463（463 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.90 Å
8Q1U Inward-facing, open1 proteoliposome complex I at 3.3 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 D 1–463（463 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 15 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 5 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.30 Å
8Q1Y Outward-facing, open2 proteoliposome complex I at 2.6 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 D 1–463（463 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 ZN ZINC ION × 2 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q25 Outward-facing, open1 proteoliposome complex I at 2.8 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 D 1–463（463 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 ZN ZINC ION × 2 MG MAGNESIUM ION × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.80 Å
8Q45 Inward-facing, closed proteoliposome complex I at 2.7 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 D 1–463（463 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 16 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.70 Å
8Q46 Inward-facing, open2 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 D 1–463（463 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q47 Inward-facing, open1 proteoliposome complex I at 2.9 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 D 1–463（463 aa）	非标准单体：是（mmCIF未提供具体位点）	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 15 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 26 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 5 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.90 Å
8Q48 Outward-facing, closed proteoliposome complex I at 2.5 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 D 1–463（463 aa）	非标准单体：是（mmCIF未提供具体位点）	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 35 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.50 Å
8Q49 Outward-facing, open2 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 D 1–463（463 aa）	非标准单体：是（mmCIF未提供具体位点）	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CHD CHOLIC ACID × 1 ZN ZINC ION × 2 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 FVH [[(2~{R},3~{S},4~{R},5~{R})-5-[(3~{R})-3-aminocarbonylpiperidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{R},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3-oxidanyl-4-phosphonooxy-oxolan-2-yl]methyl hydrogen phosphate × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q4A Outward-facing, open1 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 D 1–463（463 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
9SMF Reduced bovine complex I in lipid nanodisc, NADH-active-Q10 提交 2025-09-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 D 1–463（463 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 20 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 8 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.51 Å
9SMG Reduced bovine complex I in lipid nanodisc, NADH-active-altQ10 提交 2025-09-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 D 1–463（463 aa）	非标准单体：是（mmCIF未提供具体位点）	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 18 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.42 Å
9SMH Reduced bovine complex I in lipid nanodisc, NADH-active-DDM 提交 2025-09-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 D 1–463（463 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 17 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 LMT DODECYL-BETA-D-MALTOSIDE × 1 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.61 Å
9SMI Reduced bovine complex I in lipid nanodisc, NADH-deactive 提交 2025-09-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 D 1–463（463 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 27 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 LMT DODECYL-BETA-D-MALTOSIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 5 CHD CHOLIC ACID × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.01 Å
9W2U Cryo-EM structure of complex I on the bovine heart submitochondrial particles, open 提交 2025-07-28	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 D 34–463（430 aa）	非标准单体：是（mmCIF未提供具体位点）	FME N-FORMYLMETHIONINE × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 18 CDL CARDIOLIPIN × 6 CHD CHOLIC ACID × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.60 Å
9W2V Cryo-EM structure of complex I on the bovine heart submitochondrial particles, closed 提交 2025-07-28	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 D 34–463（430 aa）	非标准单体：是（mmCIF未提供具体位点）	FME N-FORMYLMETHIONINE × 4 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 19 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 12 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 6 MG MAGNESIUM ION × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.80 Å

共 49 个其他 PDB 条目、49 个 assembly。 打开独立比较页并筛选聚集状态

查看构建体与数据证据

UniProt名称	NDUS2_BOVIN
Isoform	—
PDB实体	4
链与序列区间	作者链 D； PDB构建体 1–426； UniProt 38–463

NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial

物种未注明

UniProt P04394

当前结构中的状态

Assembly	聚集状态	构建体	突变与修饰	配体、离子与共同组分	实验方法与环境	结构质量
1	蛋白异源复合物 异源复合物 蛋白 × 45 PDB 声明：45-meric（45） 与蛋白拷贝数一致	链 E； UniProt 1–249	未记录	NADH-ubiquinone oxidoreductase chain 3 × 1 （P03898） NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial × 1 （P42026） NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial × 1 （P23709） NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial × 1 （P17694） NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial × 1 （P25708） ;NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, NDUFS1 ; × 1 （P15690） NADH-ubiquinone oxidoreductase chain 1 × 1 （P03887） NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial × 1 （P42028） NADH-ubiquinone oxidoreductase chain 6 × 1 （P03924） NADH-ubiquinone oxidoreductase chain 4L × 1 （P03902） NADH-ubiquinone oxidoreductase chain 5 × 1 （P03920） NADH-ubiquinone oxidoreductase chain 4 × 1 （P03910） NADH-ubiquinone oxidoreductase chain 2 × 1 （P03892） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, NDUFA10,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial ; × 1 （P34942） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial × 1 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial × 1 ;NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial ; × 1 （P23934） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 × 1 （Q02370） Acyl carrier protein, mitochondrial × 1 （P52505） Acyl carrier protein, mitochondrial × 1 （P52505） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 × 1 （P23935） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 × 1 （Q02366） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 ; × 1 （P42029） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 × 1 （Q8HXG6） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 ; × 1 （Q95KV7） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 × 1 （Q02377） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 ; × 1 （Q02371） NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial × 1 （Q02376） ;NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2 ; × 1 （Q02827） NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 × 1 （Q02379） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 × 1 （Q02378） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial × 1 （Q8HXG5） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial ; × 1 （Q02380） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 ; × 1 （Q02367） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, NDUFB2 × 1 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3, NDUFB3 × 1 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, NDUFB8 × 1 ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 ; × 1 （P48305） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 ; × 1 （Q02369） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 × 1 （Q02368） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10, NDUFB10,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10, NDUFB10 ; × 1 （Q02373） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 × 1 （O97725） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7, NDUFA7 × 1 NADH dehydrogenase [ubiquinone] flavoprotein 3, NDUFV3 × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液：pH 8 cryo-EM玻璃化条件：冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 4.35 Å

数据库中的同蛋白其他状态

以下每一行都是同一 UniProt 蛋白在另一个 PDB 条目中的 biological assembly， “相对当前条目”直接指出证据层面的不同；没有差异标签表示当前已读取字段一致。

其他 PDB	相对当前条目 5LC5	Assembly / 聚集状态	构建体	突变与修饰	配体、离子与非聚合物	实验方法与环境	结构质量
5LDW Structure of mammalian respiratory Complex I, class1 提交 2016-06-28	构建体不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 E 33–249（217 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8；20 mM TRIS-HCL, 150 mM NaCl, 0.03% CYMAL-7 cryo-EM玻璃化条件 冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus present in a cold room, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 4.27 Å
5LDX Structure of mammalian respiratory Complex I, class3. 提交 2016-06-28	构建体不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 E 33–249（217 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 20 mM TRIS-HCL, 150 mM NaCl, 0.03% CYMAL-7；pH 8 cryo-EM玻璃化条件 冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 5.60 Å
5O31 Mitochondrial complex I in the deactive state 提交 2017-05-23	构建体不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 E 33–249（217 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.55 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.13 Å
7DGQ Activity optimized supercomplex state1 提交 2020-11-12	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 9 33–249（217 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 CU COPPER (II) ION × 3 HEA HEME-A × 2 MG MAGNESIUM ION × 1 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 UQ2 UBIQUINONE-2 × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 5.00 Å
7DGR Activity optimized supercomplex state2 提交 2020-11-12	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 9 33–249（217 aa）	未记录	FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 3 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.60 Å
7DGS Activity optimized supercomplex state3 提交 2020-11-12	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 9 33–249（217 aa）	未记录	FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 7.80 Å
7DGZ Activity optimized complex I (closed form) 提交 2020-11-12	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 9 33–249（217 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 2 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 3.80 Å
7DH0 Activity optimized complex I (open form) 提交 2020-11-12	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 9 33–249（217 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.20 Å
7DKF Activity optimized supercomplex state4 提交 2020-11-24	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 92 33–249（217 aa）	未记录	HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 8.30 Å
7QSD Bovine complex I in the active state at 3.1 A 提交 2022-01-13	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 E 1–249（249 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 13 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 CDL CARDIOLIPIN × 4 LMT DODECYL-BETA-D-MALTOSIDE × 3 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 3.10 Å
7QSK Bovine complex I in lipid nanodisc, Active-Q10 提交 2022-01-13	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 E 1–249（249 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 19 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.84 Å
7QSL Bovine complex I in lipid nanodisc, Active-apo 提交 2022-01-13	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 E 1–249（249 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 20 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 8 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.76 Å
7QSM Bovine complex I in lipid nanodisc, Deactive-ligand (composite) 提交 2022-01-13	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 E 1–249（249 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 GOL GLYCEROL × 1 LMT DODECYL-BETA-D-MALTOSIDE × 1 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.30 Å
7QSN Bovine complex I in lipid nanodisc, Deactive-apo 提交 2022-01-13	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 E 1–249（249 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 6 CHD CHOLIC ACID × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.81 Å
7QSO Bovine complex I in lipid nanodisc, State 3 (Slack) 提交 2022-01-13	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 E 1–249（249 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 6 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CHD CHOLIC ACID × 2 CDL CARDIOLIPIN × 6 U10 UBIQUINONE-10 × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 3.02 Å
7R41 Bovine complex I in the presence of IM1761092, active class i (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 E 1–249（249 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 16 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R42 Bovine complex I in the presence of IM1761092, active class ii (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 E 1–249（249 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 17 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R43 Bovine complex I in the presence of IM1761092, active class iii (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 E 1–249（249 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 CDL CARDIOLIPIN × 5 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R44 Bovine complex I in the presence of IM1761092, active class iv (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 E 1–249（249 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 11 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R45 Bovine complex I in the presence of IM1761092, deactive class i (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 E 1–249（249 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R46 Bovine complex I in the presence of IM1761092, deactive class ii (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 E 1–249（249 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 11 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R47 Bovine complex I in the presence of IM1761092, deactive class iii (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 E 1–249（249 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R48 Bovine complex I in the presence of IM1761092, deactive class iv (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 E 1–249（249 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 15 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 13 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4C Bovine complex I in the presence of IM1761092, deactive class v (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 E 1–249（249 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 12 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4D Bovine complex I in the presence of IM1761092, deactive class vi (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 E 1–249（249 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4F Bovine complex I in the presence of IM1761092, slack class i (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 E 1–249（249 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 7 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 3 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 CDL CARDIOLIPIN × 6 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R4G Bovine complex I in the presence of IM1761092, slack class ii (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 E 1–249（249 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 LMT DODECYL-BETA-D-MALTOSIDE × 10 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.50 Å
8Q0A Inward-facing, closed proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 E 1–249（249 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 16 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 8 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 MG MAGNESIUM ION × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0F Inward-facing, open2 proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 E 1–249（249 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 21 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0J Inward-facing, slack proteoliposome complex I at 3.8 A. Initially purified in DDM. 提交 2023-07-28	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 E 1–249（249 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 4 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.80 Å
8Q0M Outward-facing, closed proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 E 1–249（249 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0O Outward-facing, open2 proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 E 1–249（249 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0Q Outward-facing, slack proteoliposome complex I at 3.6 A. Initially purified in DDM 提交 2023-07-28	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 E 1–249（249 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 4 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.60 Å
8Q1P Inward-facing, open2 proteoliposome complex I at 2.9 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 E 1–249（249 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.90 Å
8Q1U Inward-facing, open1 proteoliposome complex I at 3.3 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 E 1–249（249 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 15 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 5 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.30 Å
8Q1Y Outward-facing, open2 proteoliposome complex I at 2.6 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 E 1–249（249 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 ZN ZINC ION × 2 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q25 Outward-facing, open1 proteoliposome complex I at 2.8 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 E 1–249（249 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 ZN ZINC ION × 2 MG MAGNESIUM ION × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.80 Å
8Q45 Inward-facing, closed proteoliposome complex I at 2.7 A. Initially purified in LMNG. 提交 2023-08-05	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 E 1–249（249 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 16 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.70 Å
8Q46 Inward-facing, open2 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 E 1–249（249 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q47 Inward-facing, open1 proteoliposome complex I at 2.9 A. Initially purified in LMNG. 提交 2023-08-05	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 E 1–249（249 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 15 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 26 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 5 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.90 Å
8Q48 Outward-facing, closed proteoliposome complex I at 2.5 A. Initially purified in LMNG. 提交 2023-08-05	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 E 1–249（249 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 35 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.50 Å
8Q49 Outward-facing, open2 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 E 1–249（249 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CHD CHOLIC ACID × 1 ZN ZINC ION × 2 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 FVH [[(2~{R},3~{S},4~{R},5~{R})-5-[(3~{R})-3-aminocarbonylpiperidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{R},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3-oxidanyl-4-phosphonooxy-oxolan-2-yl]methyl hydrogen phosphate × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q4A Outward-facing, open1 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 E 1–249（249 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
9SMF Reduced bovine complex I in lipid nanodisc, NADH-active-Q10 提交 2025-09-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 E 1–249（249 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 20 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 8 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.51 Å
9SMG Reduced bovine complex I in lipid nanodisc, NADH-active-altQ10 提交 2025-09-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 E 1–249（249 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 18 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.42 Å
9SMH Reduced bovine complex I in lipid nanodisc, NADH-active-DDM 提交 2025-09-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 E 1–249（249 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 17 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 LMT DODECYL-BETA-D-MALTOSIDE × 1 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.61 Å
9SMI Reduced bovine complex I in lipid nanodisc, NADH-deactive 提交 2025-09-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 E 1–249（249 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 27 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 LMT DODECYL-BETA-D-MALTOSIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 5 CHD CHOLIC ACID × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.01 Å
9W2U Cryo-EM structure of complex I on the bovine heart submitochondrial particles, open 提交 2025-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 E 36–249（214 aa）	未记录	FME N-FORMYLMETHIONINE × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 18 CDL CARDIOLIPIN × 6 CHD CHOLIC ACID × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.60 Å
9W2V Cryo-EM structure of complex I on the bovine heart submitochondrial particles, closed 提交 2025-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 E 36–249（214 aa）	未记录	FME N-FORMYLMETHIONINE × 4 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 19 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 12 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 6 MG MAGNESIUM ION × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.80 Å

共 49 个其他 PDB 条目、49 个 assembly。 打开独立比较页并筛选聚集状态

查看构建体与数据证据

UniProt名称	NDUV2_BOVIN
Isoform	—
PDB实体	5
链与序列区间	作者链 E； PDB构建体 1–249； UniProt 1–249

NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial

物种未注明

UniProt P25708

当前结构中的状态

Assembly	聚集状态	构建体	突变与修饰	配体、离子与共同组分	实验方法与环境	结构质量
1	蛋白异源复合物 异源复合物 蛋白 × 45 PDB 声明：45-meric（45） 与蛋白拷贝数一致	链 F； UniProt 1–464	未记录	NADH-ubiquinone oxidoreductase chain 3 × 1 （P03898） NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial × 1 （P42026） NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial × 1 （P23709） NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial × 1 （P17694） NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial × 1 （P04394） ;NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, NDUFS1 ; × 1 （P15690） NADH-ubiquinone oxidoreductase chain 1 × 1 （P03887） NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial × 1 （P42028） NADH-ubiquinone oxidoreductase chain 6 × 1 （P03924） NADH-ubiquinone oxidoreductase chain 4L × 1 （P03902） NADH-ubiquinone oxidoreductase chain 5 × 1 （P03920） NADH-ubiquinone oxidoreductase chain 4 × 1 （P03910） NADH-ubiquinone oxidoreductase chain 2 × 1 （P03892） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, NDUFA10,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial ; × 1 （P34942） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial × 1 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial × 1 ;NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial ; × 1 （P23934） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 × 1 （Q02370） Acyl carrier protein, mitochondrial × 1 （P52505） Acyl carrier protein, mitochondrial × 1 （P52505） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 × 1 （P23935） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 × 1 （Q02366） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 ; × 1 （P42029） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 × 1 （Q8HXG6） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 ; × 1 （Q95KV7） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 × 1 （Q02377） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 ; × 1 （Q02371） NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial × 1 （Q02376） ;NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2 ; × 1 （Q02827） NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 × 1 （Q02379） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 × 1 （Q02378） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial × 1 （Q8HXG5） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial ; × 1 （Q02380） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 ; × 1 （Q02367） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, NDUFB2 × 1 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3, NDUFB3 × 1 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, NDUFB8 × 1 ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 ; × 1 （P48305） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 ; × 1 （Q02369） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 × 1 （Q02368） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10, NDUFB10,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10, NDUFB10 ; × 1 （Q02373） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 × 1 （O97725） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7, NDUFA7 × 1 NADH dehydrogenase [ubiquinone] flavoprotein 3, NDUFV3 × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液：pH 8 cryo-EM玻璃化条件：冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 4.35 Å

数据库中的同蛋白其他状态

以下每一行都是同一 UniProt 蛋白在另一个 PDB 条目中的 biological assembly， “相对当前条目”直接指出证据层面的不同；没有差异标签表示当前已读取字段一致。

其他 PDB	相对当前条目 5LC5	Assembly / 聚集状态	构建体	突变与修饰	配体、离子与非聚合物	实验方法与环境	结构质量
5LDW Structure of mammalian respiratory Complex I, class1 提交 2016-06-28	构建体不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 F 21–464（444 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8；20 mM TRIS-HCL, 150 mM NaCl, 0.03% CYMAL-7 cryo-EM玻璃化条件 冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus present in a cold room, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 4.27 Å
5LDX Structure of mammalian respiratory Complex I, class3. 提交 2016-06-28	构建体不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 F 21–464（444 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 20 mM TRIS-HCL, 150 mM NaCl, 0.03% CYMAL-7；pH 8 cryo-EM玻璃化条件 冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 5.60 Å
5O31 Mitochondrial complex I in the deactive state 提交 2017-05-23	实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 F 1–464（464 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.55 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.13 Å
7DGQ Activity optimized supercomplex state1 提交 2020-11-12	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 8 21–464（444 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 CU COPPER (II) ION × 3 HEA HEME-A × 2 MG MAGNESIUM ION × 1 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 UQ2 UBIQUINONE-2 × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 5.00 Å
7DGR Activity optimized supercomplex state2 提交 2020-11-12	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 8 21–464（444 aa）	未记录	FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 3 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.60 Å
7DGS Activity optimized supercomplex state3 提交 2020-11-12	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 8 21–464（444 aa）	未记录	FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 7.80 Å
7DGZ Activity optimized complex I (closed form) 提交 2020-11-12	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 8 21–464（444 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 2 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 3.80 Å
7DH0 Activity optimized complex I (open form) 提交 2020-11-12	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 8 21–464（444 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.20 Å
7DKF Activity optimized supercomplex state4 提交 2020-11-24	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 82 21–464（444 aa）	未记录	HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 8.30 Å
7QSD Bovine complex I in the active state at 3.1 A 提交 2022-01-13	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 F 1–464（464 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 13 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 CDL CARDIOLIPIN × 4 LMT DODECYL-BETA-D-MALTOSIDE × 3 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 3.10 Å
7QSK Bovine complex I in lipid nanodisc, Active-Q10 提交 2022-01-13	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 F 1–464（464 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 19 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.84 Å
7QSL Bovine complex I in lipid nanodisc, Active-apo 提交 2022-01-13	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 F 1–464（464 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 20 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 8 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.76 Å
7QSM Bovine complex I in lipid nanodisc, Deactive-ligand (composite) 提交 2022-01-13	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 F 1–464（464 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 GOL GLYCEROL × 1 LMT DODECYL-BETA-D-MALTOSIDE × 1 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.30 Å
7QSN Bovine complex I in lipid nanodisc, Deactive-apo 提交 2022-01-13	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 F 1–464（464 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 6 CHD CHOLIC ACID × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.81 Å
7QSO Bovine complex I in lipid nanodisc, State 3 (Slack) 提交 2022-01-13	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 F 1–464（464 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 6 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CHD CHOLIC ACID × 2 CDL CARDIOLIPIN × 6 U10 UBIQUINONE-10 × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 3.02 Å
7R41 Bovine complex I in the presence of IM1761092, active class i (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 F 1–464（464 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 16 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R42 Bovine complex I in the presence of IM1761092, active class ii (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 F 1–464（464 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 17 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R43 Bovine complex I in the presence of IM1761092, active class iii (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 F 1–464（464 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 CDL CARDIOLIPIN × 5 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R44 Bovine complex I in the presence of IM1761092, active class iv (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 F 1–464（464 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 11 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R45 Bovine complex I in the presence of IM1761092, deactive class i (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 F 1–464（464 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R46 Bovine complex I in the presence of IM1761092, deactive class ii (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 F 1–464（464 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 11 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R47 Bovine complex I in the presence of IM1761092, deactive class iii (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 F 1–464（464 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R48 Bovine complex I in the presence of IM1761092, deactive class iv (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 F 1–464（464 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 15 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 13 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4C Bovine complex I in the presence of IM1761092, deactive class v (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 F 1–464（464 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 12 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4D Bovine complex I in the presence of IM1761092, deactive class vi (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 F 1–464（464 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4F Bovine complex I in the presence of IM1761092, slack class i (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 F 1–464（464 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 7 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 3 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 CDL CARDIOLIPIN × 6 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R4G Bovine complex I in the presence of IM1761092, slack class ii (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 F 1–464（464 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 LMT DODECYL-BETA-D-MALTOSIDE × 10 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.50 Å
8Q0A Inward-facing, closed proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 F 1–464（464 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 16 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 8 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 MG MAGNESIUM ION × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0F Inward-facing, open2 proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 F 1–464（464 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 21 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0J Inward-facing, slack proteoliposome complex I at 3.8 A. Initially purified in DDM. 提交 2023-07-28	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 F 1–464（464 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 4 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.80 Å
8Q0M Outward-facing, closed proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 F 1–464（464 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0O Outward-facing, open2 proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 F 1–464（464 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0Q Outward-facing, slack proteoliposome complex I at 3.6 A. Initially purified in DDM 提交 2023-07-28	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 F 1–464（464 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 4 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.60 Å
8Q1P Inward-facing, open2 proteoliposome complex I at 2.9 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 F 1–464（464 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.90 Å
8Q1U Inward-facing, open1 proteoliposome complex I at 3.3 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 F 1–464（464 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 15 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 5 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.30 Å
8Q1Y Outward-facing, open2 proteoliposome complex I at 2.6 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 F 1–464（464 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 ZN ZINC ION × 2 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q25 Outward-facing, open1 proteoliposome complex I at 2.8 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 F 1–464（464 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 ZN ZINC ION × 2 MG MAGNESIUM ION × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.80 Å
8Q45 Inward-facing, closed proteoliposome complex I at 2.7 A. Initially purified in LMNG. 提交 2023-08-05	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 F 1–464（464 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 16 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.70 Å
8Q46 Inward-facing, open2 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 F 1–464（464 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q47 Inward-facing, open1 proteoliposome complex I at 2.9 A. Initially purified in LMNG. 提交 2023-08-05	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 F 1–464（464 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 15 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 26 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 5 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.90 Å
8Q48 Outward-facing, closed proteoliposome complex I at 2.5 A. Initially purified in LMNG. 提交 2023-08-05	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 F 1–464（464 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 35 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.50 Å
8Q49 Outward-facing, open2 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 F 1–464（464 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CHD CHOLIC ACID × 1 ZN ZINC ION × 2 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 FVH [[(2~{R},3~{S},4~{R},5~{R})-5-[(3~{R})-3-aminocarbonylpiperidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{R},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3-oxidanyl-4-phosphonooxy-oxolan-2-yl]methyl hydrogen phosphate × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q4A Outward-facing, open1 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 F 1–464（464 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
9SMF Reduced bovine complex I in lipid nanodisc, NADH-active-Q10 提交 2025-09-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 F 1–464（464 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 20 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 8 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.51 Å
9SMG Reduced bovine complex I in lipid nanodisc, NADH-active-altQ10 提交 2025-09-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 F 1–464（464 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 18 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.42 Å
9SMH Reduced bovine complex I in lipid nanodisc, NADH-active-DDM 提交 2025-09-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 F 1–464（464 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 17 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 LMT DODECYL-BETA-D-MALTOSIDE × 1 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.61 Å
9SMI Reduced bovine complex I in lipid nanodisc, NADH-deactive 提交 2025-09-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 F 1–464（464 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 27 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 LMT DODECYL-BETA-D-MALTOSIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 5 CHD CHOLIC ACID × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.01 Å
9W2U Cryo-EM structure of complex I on the bovine heart submitochondrial particles, open 提交 2025-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 F 27–458（432 aa）	未记录	FME N-FORMYLMETHIONINE × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 18 CDL CARDIOLIPIN × 6 CHD CHOLIC ACID × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.60 Å
9W2V Cryo-EM structure of complex I on the bovine heart submitochondrial particles, closed 提交 2025-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 F 27–458（432 aa）	未记录	FME N-FORMYLMETHIONINE × 4 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 19 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 12 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 6 MG MAGNESIUM ION × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.80 Å

共 49 个其他 PDB 条目、49 个 assembly。 打开独立比较页并筛选聚集状态

查看构建体与数据证据

UniProt名称	NDUV1_BOVIN
Isoform	—
PDB实体	6
链与序列区间	作者链 F； PDB构建体 1–464； UniProt 1–464

;NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, NDUFS1 ;

物种未注明

UniProt P15690

当前结构中的状态

Assembly	聚集状态	构建体	突变与修饰	配体、离子与共同组分	实验方法与环境	结构质量
1	蛋白异源复合物 异源复合物 蛋白 × 45 PDB 声明：45-meric（45） 与蛋白拷贝数一致	链 G； UniProt 1–232	未记录	NADH-ubiquinone oxidoreductase chain 3 × 1 （P03898） NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial × 1 （P42026） NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial × 1 （P23709） NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial × 1 （P17694） NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial × 1 （P04394） NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial × 1 （P25708） NADH-ubiquinone oxidoreductase chain 1 × 1 （P03887） NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial × 1 （P42028） NADH-ubiquinone oxidoreductase chain 6 × 1 （P03924） NADH-ubiquinone oxidoreductase chain 4L × 1 （P03902） NADH-ubiquinone oxidoreductase chain 5 × 1 （P03920） NADH-ubiquinone oxidoreductase chain 4 × 1 （P03910） NADH-ubiquinone oxidoreductase chain 2 × 1 （P03892） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, NDUFA10,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial ; × 1 （P34942） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial × 1 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial × 1 ;NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial ; × 1 （P23934） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 × 1 （Q02370） Acyl carrier protein, mitochondrial × 1 （P52505） Acyl carrier protein, mitochondrial × 1 （P52505） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 × 1 （P23935） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 × 1 （Q02366） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 ; × 1 （P42029） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 × 1 （Q8HXG6） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 ; × 1 （Q95KV7） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 × 1 （Q02377） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 ; × 1 （Q02371） NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial × 1 （Q02376） ;NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2 ; × 1 （Q02827） NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 × 1 （Q02379） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 × 1 （Q02378） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial × 1 （Q8HXG5） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial ; × 1 （Q02380） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 ; × 1 （Q02367） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, NDUFB2 × 1 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3, NDUFB3 × 1 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, NDUFB8 × 1 ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 ; × 1 （P48305） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 ; × 1 （Q02369） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 × 1 （Q02368） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10, NDUFB10,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10, NDUFB10 ; × 1 （Q02373） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 × 1 （O97725） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7, NDUFA7 × 1 NADH dehydrogenase [ubiquinone] flavoprotein 3, NDUFV3 × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液：pH 8 cryo-EM玻璃化条件：冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 4.35 Å

数据库中的同蛋白其他状态

以下每一行都是同一 UniProt 蛋白在另一个 PDB 条目中的 biological assembly， “相对当前条目”直接指出证据层面的不同；没有差异标签表示当前已读取字段一致。

其他 PDB	相对当前条目 5LC5	Assembly / 聚集状态	构建体	突变与修饰	配体、离子与非聚合物	实验方法与环境	结构质量
5LDW Structure of mammalian respiratory Complex I, class1 提交 2016-06-28	构建体不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 G 31–232（202 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8；20 mM TRIS-HCL, 150 mM NaCl, 0.03% CYMAL-7 cryo-EM玻璃化条件 冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus present in a cold room, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 4.27 Å
5LDX Structure of mammalian respiratory Complex I, class3. 提交 2016-06-28	构建体不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 G 31–232（202 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 20 mM TRIS-HCL, 150 mM NaCl, 0.03% CYMAL-7；pH 8 cryo-EM玻璃化条件 冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 5.60 Å
5O31 Mitochondrial complex I in the deactive state 提交 2017-05-23	构建体不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 G 24–727（704 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.55 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.13 Å
7DGQ Activity optimized supercomplex state1 提交 2020-11-12	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 A 24–727（704 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 CU COPPER (II) ION × 3 HEA HEME-A × 2 MG MAGNESIUM ION × 1 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 UQ2 UBIQUINONE-2 × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 5.00 Å
7DGR Activity optimized supercomplex state2 提交 2020-11-12	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 A 24–727（704 aa）	未记录	FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 3 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.60 Å
7DGS Activity optimized supercomplex state3 提交 2020-11-12	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 A 24–727（704 aa）	未记录	FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 7.80 Å
7DGZ Activity optimized complex I (closed form) 提交 2020-11-12	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 A 24–727（704 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 2 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 3.80 Å
7DH0 Activity optimized complex I (open form) 提交 2020-11-12	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 A 24–727（704 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.20 Å
7DKF Activity optimized supercomplex state4 提交 2020-11-24	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 A2 24–727（704 aa）	未记录	HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 8.30 Å
7QSD Bovine complex I in the active state at 3.1 A 提交 2022-01-13	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 G 1–727（727 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 13 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 CDL CARDIOLIPIN × 4 LMT DODECYL-BETA-D-MALTOSIDE × 3 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 3.10 Å
7QSK Bovine complex I in lipid nanodisc, Active-Q10 提交 2022-01-13	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 G 1–727（727 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 19 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.84 Å
7QSL Bovine complex I in lipid nanodisc, Active-apo 提交 2022-01-13	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 G 1–727（727 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 20 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 8 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.76 Å
7QSM Bovine complex I in lipid nanodisc, Deactive-ligand (composite) 提交 2022-01-13	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 G 1–727（727 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 GOL GLYCEROL × 1 LMT DODECYL-BETA-D-MALTOSIDE × 1 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.30 Å
7QSN Bovine complex I in lipid nanodisc, Deactive-apo 提交 2022-01-13	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 G 1–727（727 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 6 CHD CHOLIC ACID × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.81 Å
7QSO Bovine complex I in lipid nanodisc, State 3 (Slack) 提交 2022-01-13	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 G 1–727（727 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 6 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CHD CHOLIC ACID × 2 CDL CARDIOLIPIN × 6 U10 UBIQUINONE-10 × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 3.02 Å
7R41 Bovine complex I in the presence of IM1761092, active class i (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 G 1–727（727 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 16 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R42 Bovine complex I in the presence of IM1761092, active class ii (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 G 1–727（727 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 17 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R43 Bovine complex I in the presence of IM1761092, active class iii (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 G 1–727（727 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 CDL CARDIOLIPIN × 5 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R44 Bovine complex I in the presence of IM1761092, active class iv (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 G 1–727（727 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 11 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R45 Bovine complex I in the presence of IM1761092, deactive class i (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 G 1–727（727 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R46 Bovine complex I in the presence of IM1761092, deactive class ii (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 G 1–727（727 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 11 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R47 Bovine complex I in the presence of IM1761092, deactive class iii (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 G 1–727（727 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R48 Bovine complex I in the presence of IM1761092, deactive class iv (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 G 1–727（727 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 15 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 13 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4C Bovine complex I in the presence of IM1761092, deactive class v (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 G 1–727（727 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 12 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4D Bovine complex I in the presence of IM1761092, deactive class vi (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 G 1–727（727 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4F Bovine complex I in the presence of IM1761092, slack class i (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 G 1–727（727 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 7 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 3 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 CDL CARDIOLIPIN × 6 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R4G Bovine complex I in the presence of IM1761092, slack class ii (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 G 1–727（727 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 LMT DODECYL-BETA-D-MALTOSIDE × 10 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.50 Å
8Q0A Inward-facing, closed proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 G 1–727（727 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 16 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 8 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 MG MAGNESIUM ION × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0F Inward-facing, open2 proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 G 1–727（727 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 21 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0J Inward-facing, slack proteoliposome complex I at 3.8 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 G 1–727（727 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 4 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.80 Å
8Q0M Outward-facing, closed proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 G 1–727（727 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0O Outward-facing, open2 proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 G 1–727（727 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0Q Outward-facing, slack proteoliposome complex I at 3.6 A. Initially purified in DDM 提交 2023-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 G 1–727（727 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 4 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.60 Å
8Q1P Inward-facing, open2 proteoliposome complex I at 2.9 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 G 1–727（727 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.90 Å
8Q1U Inward-facing, open1 proteoliposome complex I at 3.3 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 G 1–727（727 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 15 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 5 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.30 Å
8Q1Y Outward-facing, open2 proteoliposome complex I at 2.6 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 G 1–727（727 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 ZN ZINC ION × 2 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q25 Outward-facing, open1 proteoliposome complex I at 2.8 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 G 1–727（727 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 ZN ZINC ION × 2 MG MAGNESIUM ION × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.80 Å
8Q45 Inward-facing, closed proteoliposome complex I at 2.7 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 G 1–727（727 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 16 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.70 Å
8Q46 Inward-facing, open2 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 G 1–727（727 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q47 Inward-facing, open1 proteoliposome complex I at 2.9 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 G 1–727（727 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 15 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 26 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 5 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.90 Å
8Q48 Outward-facing, closed proteoliposome complex I at 2.5 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 G 1–727（727 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 35 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.50 Å
8Q49 Outward-facing, open2 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 G 1–727（727 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CHD CHOLIC ACID × 1 ZN ZINC ION × 2 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 FVH [[(2~{R},3~{S},4~{R},5~{R})-5-[(3~{R})-3-aminocarbonylpiperidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{R},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3-oxidanyl-4-phosphonooxy-oxolan-2-yl]methyl hydrogen phosphate × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q4A Outward-facing, open1 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 G 1–727（727 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
9SMF Reduced bovine complex I in lipid nanodisc, NADH-active-Q10 提交 2025-09-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 G 1–727（727 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 20 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 8 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.51 Å
9SMG Reduced bovine complex I in lipid nanodisc, NADH-active-altQ10 提交 2025-09-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 G 1–727（727 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 18 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.42 Å
9SMH Reduced bovine complex I in lipid nanodisc, NADH-active-DDM 提交 2025-09-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 G 1–727（727 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 17 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 LMT DODECYL-BETA-D-MALTOSIDE × 1 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.61 Å
9SMI Reduced bovine complex I in lipid nanodisc, NADH-deactive 提交 2025-09-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 G 1–727（727 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 27 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 LMT DODECYL-BETA-D-MALTOSIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 5 CHD CHOLIC ACID × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.01 Å
9W2U Cryo-EM structure of complex I on the bovine heart submitochondrial particles, open 提交 2025-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 G 29–727（699 aa）	未记录	FME N-FORMYLMETHIONINE × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 18 CDL CARDIOLIPIN × 6 CHD CHOLIC ACID × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.60 Å
9W2V Cryo-EM structure of complex I on the bovine heart submitochondrial particles, closed 提交 2025-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 G 29–727（699 aa）	未记录	FME N-FORMYLMETHIONINE × 4 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 19 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 12 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 6 MG MAGNESIUM ION × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.80 Å

共 49 个其他 PDB 条目、49 个 assembly。 打开独立比较页并筛选聚集状态

查看构建体与数据证据

UniProt名称	NDUS1_BOVIN
Isoform	—
PDB实体	7
链与序列区间	作者链 G； PDB构建体 1–232； UniProt 1–232

NADH-ubiquinone oxidoreductase chain 1

物种未注明

UniProt P03887

当前结构中的状态

Assembly	聚集状态	构建体	突变与修饰	配体、离子与共同组分	实验方法与环境	结构质量
1	蛋白异源复合物 异源复合物 蛋白 × 45 PDB 声明：45-meric（45） 与蛋白拷贝数一致	链 H； UniProt 3–315	未记录	NADH-ubiquinone oxidoreductase chain 3 × 1 （P03898） NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial × 1 （P42026） NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial × 1 （P23709） NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial × 1 （P17694） NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial × 1 （P04394） NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial × 1 （P25708） ;NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, NDUFS1 ; × 1 （P15690） NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial × 1 （P42028） NADH-ubiquinone oxidoreductase chain 6 × 1 （P03924） NADH-ubiquinone oxidoreductase chain 4L × 1 （P03902） NADH-ubiquinone oxidoreductase chain 5 × 1 （P03920） NADH-ubiquinone oxidoreductase chain 4 × 1 （P03910） NADH-ubiquinone oxidoreductase chain 2 × 1 （P03892） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, NDUFA10,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial ; × 1 （P34942） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial × 1 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial × 1 ;NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial ; × 1 （P23934） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 × 1 （Q02370） Acyl carrier protein, mitochondrial × 1 （P52505） Acyl carrier protein, mitochondrial × 1 （P52505） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 × 1 （P23935） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 × 1 （Q02366） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 ; × 1 （P42029） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 × 1 （Q8HXG6） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 ; × 1 （Q95KV7） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 × 1 （Q02377） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 ; × 1 （Q02371） NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial × 1 （Q02376） ;NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2 ; × 1 （Q02827） NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 × 1 （Q02379） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 × 1 （Q02378） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial × 1 （Q8HXG5） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial ; × 1 （Q02380） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 ; × 1 （Q02367） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, NDUFB2 × 1 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3, NDUFB3 × 1 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, NDUFB8 × 1 ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 ; × 1 （P48305） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 ; × 1 （Q02369） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 × 1 （Q02368） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10, NDUFB10,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10, NDUFB10 ; × 1 （Q02373） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 × 1 （O97725） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7, NDUFA7 × 1 NADH dehydrogenase [ubiquinone] flavoprotein 3, NDUFV3 × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液：pH 8 cryo-EM玻璃化条件：冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 4.35 Å

数据库中的同蛋白其他状态

以下每一行都是同一 UniProt 蛋白在另一个 PDB 条目中的 biological assembly， “相对当前条目”直接指出证据层面的不同；没有差异标签表示当前已读取字段一致。

其他 PDB	相对当前条目 5LC5	Assembly / 聚集状态	构建体	突变与修饰	配体、离子与非聚合物	实验方法与环境	结构质量
5LDW Structure of mammalian respiratory Complex I, class1 提交 2016-06-28	构建体不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 H 1–318（318 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8；20 mM TRIS-HCL, 150 mM NaCl, 0.03% CYMAL-7 cryo-EM玻璃化条件 冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus present in a cold room, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 4.27 Å
5LDX Structure of mammalian respiratory Complex I, class3. 提交 2016-06-28	构建体不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 H 1–318（318 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 20 mM TRIS-HCL, 150 mM NaCl, 0.03% CYMAL-7；pH 8 cryo-EM玻璃化条件 冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 5.60 Å
5O31 Mitochondrial complex I in the deactive state 提交 2017-05-23	构建体不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 H 1–318（318 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.55 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.13 Å
7DGQ Activity optimized supercomplex state1 提交 2020-11-12	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 1 1–318（318 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 CU COPPER (II) ION × 3 HEA HEME-A × 2 MG MAGNESIUM ION × 1 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 UQ2 UBIQUINONE-2 × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 5.00 Å
7DGR Activity optimized supercomplex state2 提交 2020-11-12	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 1 1–318（318 aa）	未记录	FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 3 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.60 Å
7DGS Activity optimized supercomplex state3 提交 2020-11-12	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 1 1–318（318 aa）	未记录	FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 7.80 Å
7DGZ Activity optimized complex I (closed form) 提交 2020-11-12	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 1 1–318（318 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 2 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 3.80 Å
7DH0 Activity optimized complex I (open form) 提交 2020-11-12	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 1 1–318（318 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.20 Å
7DKF Activity optimized supercomplex state4 提交 2020-11-24	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 12 1–318（318 aa）	未记录	HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 8.30 Å
7QSD Bovine complex I in the active state at 3.1 A 提交 2022-01-13	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 H 1–318（318 aa）	非标准单体：是（mmCIF未提供具体位点）	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 13 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 CDL CARDIOLIPIN × 4 LMT DODECYL-BETA-D-MALTOSIDE × 3 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 3.10 Å
7QSK Bovine complex I in lipid nanodisc, Active-Q10 提交 2022-01-13	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 H 1–318（318 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 19 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.84 Å
7QSL Bovine complex I in lipid nanodisc, Active-apo 提交 2022-01-13	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 H 1–318（318 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 20 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 8 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.76 Å
7QSM Bovine complex I in lipid nanodisc, Deactive-ligand (composite) 提交 2022-01-13	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 H 1–318（318 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 GOL GLYCEROL × 1 LMT DODECYL-BETA-D-MALTOSIDE × 1 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.30 Å
7QSN Bovine complex I in lipid nanodisc, Deactive-apo 提交 2022-01-13	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 H 1–318（318 aa）	非标准单体：是（mmCIF未提供具体位点）	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 6 CHD CHOLIC ACID × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.81 Å
7QSO Bovine complex I in lipid nanodisc, State 3 (Slack) 提交 2022-01-13	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 H 1–318（318 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 6 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CHD CHOLIC ACID × 2 CDL CARDIOLIPIN × 6 U10 UBIQUINONE-10 × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 3.02 Å
7R41 Bovine complex I in the presence of IM1761092, active class i (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 H 1–318（318 aa）	非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 16 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R42 Bovine complex I in the presence of IM1761092, active class ii (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 H 1–318（318 aa）	非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 17 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R43 Bovine complex I in the presence of IM1761092, active class iii (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 H 1–318（318 aa）	非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 CDL CARDIOLIPIN × 5 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R44 Bovine complex I in the presence of IM1761092, active class iv (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 H 1–318（318 aa）	非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 11 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R45 Bovine complex I in the presence of IM1761092, deactive class i (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 H 1–318（318 aa）	非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R46 Bovine complex I in the presence of IM1761092, deactive class ii (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 H 1–318（318 aa）	非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 11 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R47 Bovine complex I in the presence of IM1761092, deactive class iii (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 H 1–318（318 aa）	非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R48 Bovine complex I in the presence of IM1761092, deactive class iv (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 H 1–318（318 aa）	非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 15 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 13 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4C Bovine complex I in the presence of IM1761092, deactive class v (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 H 1–318（318 aa）	非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 12 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4D Bovine complex I in the presence of IM1761092, deactive class vi (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 H 1–318（318 aa）	非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4F Bovine complex I in the presence of IM1761092, slack class i (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 H 1–318（318 aa）	非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 7 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 3 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 CDL CARDIOLIPIN × 6 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R4G Bovine complex I in the presence of IM1761092, slack class ii (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 H 1–318（318 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 LMT DODECYL-BETA-D-MALTOSIDE × 10 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.50 Å
8Q0A Inward-facing, closed proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 H 1–318（318 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 16 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 8 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 MG MAGNESIUM ION × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0F Inward-facing, open2 proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 H 1–318（318 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 21 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0J Inward-facing, slack proteoliposome complex I at 3.8 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 H 1–318（318 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 4 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.80 Å
8Q0M Outward-facing, closed proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 H 1–318（318 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0O Outward-facing, open2 proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 H 1–318（318 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0Q Outward-facing, slack proteoliposome complex I at 3.6 A. Initially purified in DDM 提交 2023-07-28	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 H 1–318（318 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 4 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.60 Å
8Q1P Inward-facing, open2 proteoliposome complex I at 2.9 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 H 1–318（318 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.90 Å
8Q1U Inward-facing, open1 proteoliposome complex I at 3.3 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 H 1–318（318 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 15 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 5 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.30 Å
8Q1Y Outward-facing, open2 proteoliposome complex I at 2.6 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 H 1–318（318 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 ZN ZINC ION × 2 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q25 Outward-facing, open1 proteoliposome complex I at 2.8 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 H 1–318（318 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 ZN ZINC ION × 2 MG MAGNESIUM ION × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.80 Å
8Q45 Inward-facing, closed proteoliposome complex I at 2.7 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 H 1–318（318 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 16 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.70 Å
8Q46 Inward-facing, open2 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 H 1–318（318 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q47 Inward-facing, open1 proteoliposome complex I at 2.9 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 H 1–318（318 aa）	非标准单体：是（mmCIF未提供具体位点）	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 15 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 26 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 5 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.90 Å
8Q48 Outward-facing, closed proteoliposome complex I at 2.5 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 H 1–318（318 aa）	非标准单体：是（mmCIF未提供具体位点）	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 35 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.50 Å
8Q49 Outward-facing, open2 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 H 1–318（318 aa）	非标准单体：是（mmCIF未提供具体位点）	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CHD CHOLIC ACID × 1 ZN ZINC ION × 2 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 FVH [[(2~{R},3~{S},4~{R},5~{R})-5-[(3~{R})-3-aminocarbonylpiperidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{R},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3-oxidanyl-4-phosphonooxy-oxolan-2-yl]methyl hydrogen phosphate × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q4A Outward-facing, open1 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 H 1–318（318 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
9SMF Reduced bovine complex I in lipid nanodisc, NADH-active-Q10 提交 2025-09-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 H 1–318（318 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 20 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 8 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.51 Å
9SMG Reduced bovine complex I in lipid nanodisc, NADH-active-altQ10 提交 2025-09-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 H 1–318（318 aa）	非标准单体：是（mmCIF未提供具体位点）	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 18 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.42 Å
9SMH Reduced bovine complex I in lipid nanodisc, NADH-active-DDM 提交 2025-09-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 H 1–318（318 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 17 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 LMT DODECYL-BETA-D-MALTOSIDE × 1 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.61 Å
9SMI Reduced bovine complex I in lipid nanodisc, NADH-deactive 提交 2025-09-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 H 1–318（318 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 27 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 LMT DODECYL-BETA-D-MALTOSIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 5 CHD CHOLIC ACID × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.01 Å
9W2U Cryo-EM structure of complex I on the bovine heart submitochondrial particles, open 提交 2025-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 H 2–318（317 aa）	未记录	FME N-FORMYLMETHIONINE × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 18 CDL CARDIOLIPIN × 6 CHD CHOLIC ACID × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.60 Å

共 48 个其他 PDB 条目、48 个 assembly。 打开独立比较页并筛选聚集状态

查看构建体与数据证据

UniProt名称	NU1M_BOVIN
Isoform	—
PDB实体	8
链与序列区间	作者链 H； PDB构建体 1–313； UniProt 3–315

NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial

物种未注明

UniProt P42028

当前结构中的状态

Assembly	聚集状态	构建体	突变与修饰	配体、离子与共同组分	实验方法与环境	结构质量
1	蛋白异源复合物 异源复合物 蛋白 × 45 PDB 声明：45-meric（45） 与蛋白拷贝数一致	链 I； UniProt 37–212	未记录	NADH-ubiquinone oxidoreductase chain 3 × 1 （P03898） NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial × 1 （P42026） NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial × 1 （P23709） NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial × 1 （P17694） NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial × 1 （P04394） NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial × 1 （P25708） ;NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, NDUFS1 ; × 1 （P15690） NADH-ubiquinone oxidoreductase chain 1 × 1 （P03887） NADH-ubiquinone oxidoreductase chain 6 × 1 （P03924） NADH-ubiquinone oxidoreductase chain 4L × 1 （P03902） NADH-ubiquinone oxidoreductase chain 5 × 1 （P03920） NADH-ubiquinone oxidoreductase chain 4 × 1 （P03910） NADH-ubiquinone oxidoreductase chain 2 × 1 （P03892） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, NDUFA10,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial ; × 1 （P34942） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial × 1 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial × 1 ;NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial ; × 1 （P23934） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 × 1 （Q02370） Acyl carrier protein, mitochondrial × 1 （P52505） Acyl carrier protein, mitochondrial × 1 （P52505） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 × 1 （P23935） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 × 1 （Q02366） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 ; × 1 （P42029） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 × 1 （Q8HXG6） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 ; × 1 （Q95KV7） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 × 1 （Q02377） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 ; × 1 （Q02371） NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial × 1 （Q02376） ;NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2 ; × 1 （Q02827） NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 × 1 （Q02379） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 × 1 （Q02378） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial × 1 （Q8HXG5） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial ; × 1 （Q02380） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 ; × 1 （Q02367） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, NDUFB2 × 1 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3, NDUFB3 × 1 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, NDUFB8 × 1 ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 ; × 1 （P48305） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 ; × 1 （Q02369） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 × 1 （Q02368） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10, NDUFB10,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10, NDUFB10 ; × 1 （Q02373） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 × 1 （O97725） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7, NDUFA7 × 1 NADH dehydrogenase [ubiquinone] flavoprotein 3, NDUFV3 × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液：pH 8 cryo-EM玻璃化条件：冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 4.35 Å

数据库中的同蛋白其他状态

以下每一行都是同一 UniProt 蛋白在另一个 PDB 条目中的 biological assembly， “相对当前条目”直接指出证据层面的不同；没有差异标签表示当前已读取字段一致。

其他 PDB	相对当前条目 5LC5	Assembly / 聚集状态	构建体	突变与修饰	配体、离子与非聚合物	实验方法与环境	结构质量
5LDW Structure of mammalian respiratory Complex I, class1 提交 2016-06-28	实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 I 37–212（176 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8；20 mM TRIS-HCL, 150 mM NaCl, 0.03% CYMAL-7 cryo-EM玻璃化条件 冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus present in a cold room, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 4.27 Å
5LDX Structure of mammalian respiratory Complex I, class3. 提交 2016-06-28	结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 I 37–212（176 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 20 mM TRIS-HCL, 150 mM NaCl, 0.03% CYMAL-7；pH 8 cryo-EM玻璃化条件 冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 5.60 Å
5O31 Mitochondrial complex I in the deactive state 提交 2017-05-23	实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 I 37–212（176 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.55 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.13 Å
7DGQ Activity optimized supercomplex state1 提交 2020-11-12	聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 E 37–212（176 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 CU COPPER (II) ION × 3 HEA HEME-A × 2 MG MAGNESIUM ION × 1 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 UQ2 UBIQUINONE-2 × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 5.00 Å
7DGR Activity optimized supercomplex state2 提交 2020-11-12	聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 E 37–212（176 aa）	未记录	FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 3 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.60 Å
7DGS Activity optimized supercomplex state3 提交 2020-11-12	聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 E 37–212（176 aa）	未记录	FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 7.80 Å
7DGZ Activity optimized complex I (closed form) 提交 2020-11-12	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 E 37–212（176 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 2 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 3.80 Å
7DH0 Activity optimized complex I (open form) 提交 2020-11-12	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 E 37–212（176 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.20 Å
7DKF Activity optimized supercomplex state4 提交 2020-11-24	聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 E2 37–212（176 aa）	未记录	HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 8.30 Å
7QSD Bovine complex I in the active state at 3.1 A 提交 2022-01-13	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 I 1–212（212 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 13 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 CDL CARDIOLIPIN × 4 LMT DODECYL-BETA-D-MALTOSIDE × 3 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 3.10 Å
7QSK Bovine complex I in lipid nanodisc, Active-Q10 提交 2022-01-13	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 I 1–212（212 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 19 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.84 Å
7QSL Bovine complex I in lipid nanodisc, Active-apo 提交 2022-01-13	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 I 1–212（212 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 20 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 8 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.76 Å
7QSM Bovine complex I in lipid nanodisc, Deactive-ligand (composite) 提交 2022-01-13	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 I 1–212（212 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 GOL GLYCEROL × 1 LMT DODECYL-BETA-D-MALTOSIDE × 1 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.30 Å
7QSN Bovine complex I in lipid nanodisc, Deactive-apo 提交 2022-01-13	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 I 1–212（212 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 6 CHD CHOLIC ACID × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.81 Å
7QSO Bovine complex I in lipid nanodisc, State 3 (Slack) 提交 2022-01-13	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 I 1–212（212 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 6 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CHD CHOLIC ACID × 2 CDL CARDIOLIPIN × 6 U10 UBIQUINONE-10 × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 3.02 Å
7R41 Bovine complex I in the presence of IM1761092, active class i (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 I 1–212（212 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 16 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R42 Bovine complex I in the presence of IM1761092, active class ii (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 I 1–212（212 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 17 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R43 Bovine complex I in the presence of IM1761092, active class iii (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 I 1–212（212 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 CDL CARDIOLIPIN × 5 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R44 Bovine complex I in the presence of IM1761092, active class iv (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 I 1–212（212 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 11 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R45 Bovine complex I in the presence of IM1761092, deactive class i (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 I 1–212（212 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R46 Bovine complex I in the presence of IM1761092, deactive class ii (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 I 1–212（212 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 11 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R47 Bovine complex I in the presence of IM1761092, deactive class iii (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 I 1–212（212 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R48 Bovine complex I in the presence of IM1761092, deactive class iv (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 I 1–212（212 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 15 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 13 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4C Bovine complex I in the presence of IM1761092, deactive class v (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 I 1–212（212 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 12 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4D Bovine complex I in the presence of IM1761092, deactive class vi (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 I 1–212（212 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4F Bovine complex I in the presence of IM1761092, slack class i (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 I 1–212（212 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 7 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 3 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 CDL CARDIOLIPIN × 6 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R4G Bovine complex I in the presence of IM1761092, slack class ii (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 I 1–212（212 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 LMT DODECYL-BETA-D-MALTOSIDE × 10 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.50 Å
8Q0A Inward-facing, closed proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 I 1–212（212 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 16 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 8 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 MG MAGNESIUM ION × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0F Inward-facing, open2 proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 I 1–212（212 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 21 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0J Inward-facing, slack proteoliposome complex I at 3.8 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 I 1–212（212 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 4 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.80 Å
8Q0M Outward-facing, closed proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 I 1–212（212 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0O Outward-facing, open2 proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 I 1–212（212 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0Q Outward-facing, slack proteoliposome complex I at 3.6 A. Initially purified in DDM 提交 2023-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 I 1–212（212 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 4 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.60 Å
8Q1P Inward-facing, open2 proteoliposome complex I at 2.9 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 I 1–212（212 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.90 Å
8Q1U Inward-facing, open1 proteoliposome complex I at 3.3 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 I 1–212（212 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 15 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 5 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.30 Å
8Q1Y Outward-facing, open2 proteoliposome complex I at 2.6 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 I 1–212（212 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 ZN ZINC ION × 2 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q25 Outward-facing, open1 proteoliposome complex I at 2.8 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 I 1–212（212 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 ZN ZINC ION × 2 MG MAGNESIUM ION × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.80 Å
8Q45 Inward-facing, closed proteoliposome complex I at 2.7 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 I 1–212（212 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 16 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.70 Å
8Q46 Inward-facing, open2 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 I 1–212（212 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q47 Inward-facing, open1 proteoliposome complex I at 2.9 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 I 1–212（212 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 15 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 26 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 5 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.90 Å
8Q48 Outward-facing, closed proteoliposome complex I at 2.5 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 I 1–212（212 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 35 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.50 Å
8Q49 Outward-facing, open2 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 I 1–212（212 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CHD CHOLIC ACID × 1 ZN ZINC ION × 2 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 FVH [[(2~{R},3~{S},4~{R},5~{R})-5-[(3~{R})-3-aminocarbonylpiperidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{R},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3-oxidanyl-4-phosphonooxy-oxolan-2-yl]methyl hydrogen phosphate × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q4A Outward-facing, open1 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 I 1–212（212 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
9SMF Reduced bovine complex I in lipid nanodisc, NADH-active-Q10 提交 2025-09-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 I 1–212（212 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 20 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 8 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.51 Å
9SMG Reduced bovine complex I in lipid nanodisc, NADH-active-altQ10 提交 2025-09-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 I 1–212（212 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 18 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.42 Å
9SMH Reduced bovine complex I in lipid nanodisc, NADH-active-DDM 提交 2025-09-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 I 1–212（212 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 17 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 LMT DODECYL-BETA-D-MALTOSIDE × 1 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.61 Å
9SMI Reduced bovine complex I in lipid nanodisc, NADH-deactive 提交 2025-09-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 I 1–212（212 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 27 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 LMT DODECYL-BETA-D-MALTOSIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 5 CHD CHOLIC ACID × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.01 Å
9W2U Cryo-EM structure of complex I on the bovine heart submitochondrial particles, open 提交 2025-07-28	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 I 37–212（176 aa）	未记录	FME N-FORMYLMETHIONINE × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 18 CDL CARDIOLIPIN × 6 CHD CHOLIC ACID × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.60 Å
9W2V Cryo-EM structure of complex I on the bovine heart submitochondrial particles, closed 提交 2025-07-28	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 I 37–212（176 aa）	未记录	FME N-FORMYLMETHIONINE × 4 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 19 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 12 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 6 MG MAGNESIUM ION × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.80 Å

共 49 个其他 PDB 条目、49 个 assembly。 打开独立比较页并筛选聚集状态

查看构建体与数据证据

UniProt名称	NDUS8_BOVIN
Isoform	—
PDB实体	9
链与序列区间	作者链 I； PDB构建体 1–176； UniProt 37–212

NADH-ubiquinone oxidoreductase chain 6

物种未注明

UniProt P03924

当前结构中的状态

Assembly	聚集状态	构建体	突变与修饰	配体、离子与共同组分	实验方法与环境	结构质量
1	蛋白异源复合物 异源复合物 蛋白 × 45 PDB 声明：45-meric（45） 与蛋白拷贝数一致	链 J； UniProt 2–172	未记录	NADH-ubiquinone oxidoreductase chain 3 × 1 （P03898） NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial × 1 （P42026） NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial × 1 （P23709） NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial × 1 （P17694） NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial × 1 （P04394） NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial × 1 （P25708） ;NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, NDUFS1 ; × 1 （P15690） NADH-ubiquinone oxidoreductase chain 1 × 1 （P03887） NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial × 1 （P42028） NADH-ubiquinone oxidoreductase chain 4L × 1 （P03902） NADH-ubiquinone oxidoreductase chain 5 × 1 （P03920） NADH-ubiquinone oxidoreductase chain 4 × 1 （P03910） NADH-ubiquinone oxidoreductase chain 2 × 1 （P03892） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, NDUFA10,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial ; × 1 （P34942） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial × 1 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial × 1 ;NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial ; × 1 （P23934） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 × 1 （Q02370） Acyl carrier protein, mitochondrial × 1 （P52505） Acyl carrier protein, mitochondrial × 1 （P52505） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 × 1 （P23935） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 × 1 （Q02366） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 ; × 1 （P42029） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 × 1 （Q8HXG6） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 ; × 1 （Q95KV7） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 × 1 （Q02377） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 ; × 1 （Q02371） NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial × 1 （Q02376） ;NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2 ; × 1 （Q02827） NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 × 1 （Q02379） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 × 1 （Q02378） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial × 1 （Q8HXG5） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial ; × 1 （Q02380） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 ; × 1 （Q02367） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, NDUFB2 × 1 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3, NDUFB3 × 1 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, NDUFB8 × 1 ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 ; × 1 （P48305） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 ; × 1 （Q02369） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 × 1 （Q02368） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10, NDUFB10,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10, NDUFB10 ; × 1 （Q02373） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 × 1 （O97725） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7, NDUFA7 × 1 NADH dehydrogenase [ubiquinone] flavoprotein 3, NDUFV3 × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液：pH 8 cryo-EM玻璃化条件：冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 4.35 Å

数据库中的同蛋白其他状态

以下每一行都是同一 UniProt 蛋白在另一个 PDB 条目中的 biological assembly， “相对当前条目”直接指出证据层面的不同；没有差异标签表示当前已读取字段一致。

其他 PDB	相对当前条目 5LC5	Assembly / 聚集状态	构建体	突变与修饰	配体、离子与非聚合物	实验方法与环境	结构质量
5LDW Structure of mammalian respiratory Complex I, class1 提交 2016-06-28	构建体不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 J 1–175（175 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8；20 mM TRIS-HCL, 150 mM NaCl, 0.03% CYMAL-7 cryo-EM玻璃化条件 冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus present in a cold room, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 4.27 Å
5LDX Structure of mammalian respiratory Complex I, class3. 提交 2016-06-28	构建体不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 J 1–175（175 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 20 mM TRIS-HCL, 150 mM NaCl, 0.03% CYMAL-7；pH 8 cryo-EM玻璃化条件 冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 5.60 Å
5O31 Mitochondrial complex I in the deactive state 提交 2017-05-23	构建体不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 J 1–175（175 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.55 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.13 Å
7DGQ Activity optimized supercomplex state1 提交 2020-11-12	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 7 1–175（175 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 CU COPPER (II) ION × 3 HEA HEME-A × 2 MG MAGNESIUM ION × 1 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 UQ2 UBIQUINONE-2 × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 5.00 Å
7DGR Activity optimized supercomplex state2 提交 2020-11-12	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 7 1–175（175 aa）	未记录	FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 3 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.60 Å
7DGS Activity optimized supercomplex state3 提交 2020-11-12	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 7 1–175（175 aa）	未记录	FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 7.80 Å
7DGZ Activity optimized complex I (closed form) 提交 2020-11-12	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 7 1–175（175 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 2 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 3.80 Å
7DH0 Activity optimized complex I (open form) 提交 2020-11-12	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 7 1–175（175 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.20 Å
7DKF Activity optimized supercomplex state4 提交 2020-11-24	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 72 1–175（175 aa）	未记录	HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 8.30 Å
7QSD Bovine complex I in the active state at 3.1 A 提交 2022-01-13	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 J 1–175（175 aa）	非标准单体：是（mmCIF未提供具体位点）	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 13 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 CDL CARDIOLIPIN × 4 LMT DODECYL-BETA-D-MALTOSIDE × 3 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 3.10 Å
7QSK Bovine complex I in lipid nanodisc, Active-Q10 提交 2022-01-13	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 J 1–175（175 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 19 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.84 Å
7QSL Bovine complex I in lipid nanodisc, Active-apo 提交 2022-01-13	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 J 1–175（175 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 20 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 8 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.76 Å
7QSM Bovine complex I in lipid nanodisc, Deactive-ligand (composite) 提交 2022-01-13	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 J 1–175（175 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 GOL GLYCEROL × 1 LMT DODECYL-BETA-D-MALTOSIDE × 1 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.30 Å
7QSN Bovine complex I in lipid nanodisc, Deactive-apo 提交 2022-01-13	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 J 1–175（175 aa）	非标准单体：是（mmCIF未提供具体位点）	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 6 CHD CHOLIC ACID × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.81 Å
7QSO Bovine complex I in lipid nanodisc, State 3 (Slack) 提交 2022-01-13	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 J 1–175（175 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 6 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CHD CHOLIC ACID × 2 CDL CARDIOLIPIN × 6 U10 UBIQUINONE-10 × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 3.02 Å
7R41 Bovine complex I in the presence of IM1761092, active class i (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 J 1–175（175 aa）	非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 16 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R42 Bovine complex I in the presence of IM1761092, active class ii (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 J 1–175（175 aa）	非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 17 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R43 Bovine complex I in the presence of IM1761092, active class iii (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 J 1–175（175 aa）	非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 CDL CARDIOLIPIN × 5 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R44 Bovine complex I in the presence of IM1761092, active class iv (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 J 1–175（175 aa）	非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 11 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R45 Bovine complex I in the presence of IM1761092, deactive class i (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 J 1–175（175 aa）	非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R46 Bovine complex I in the presence of IM1761092, deactive class ii (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 J 1–175（175 aa）	非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 11 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R47 Bovine complex I in the presence of IM1761092, deactive class iii (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 J 1–175（175 aa）	非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R48 Bovine complex I in the presence of IM1761092, deactive class iv (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 J 1–175（175 aa）	非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 15 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 13 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4C Bovine complex I in the presence of IM1761092, deactive class v (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 J 1–175（175 aa）	非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 12 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4D Bovine complex I in the presence of IM1761092, deactive class vi (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 J 1–175（175 aa）	非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4F Bovine complex I in the presence of IM1761092, slack class i (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 J 1–175（175 aa）	非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 7 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 3 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 CDL CARDIOLIPIN × 6 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R4G Bovine complex I in the presence of IM1761092, slack class ii (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 J 1–175（175 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 LMT DODECYL-BETA-D-MALTOSIDE × 10 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.50 Å
8Q0A Inward-facing, closed proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 J 1–175（175 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 16 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 8 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 MG MAGNESIUM ION × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0F Inward-facing, open2 proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 J 1–175（175 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 21 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0J Inward-facing, slack proteoliposome complex I at 3.8 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 J 1–175（175 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 4 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.80 Å
8Q0M Outward-facing, closed proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 J 1–175（175 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0O Outward-facing, open2 proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 J 1–175（175 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0Q Outward-facing, slack proteoliposome complex I at 3.6 A. Initially purified in DDM 提交 2023-07-28	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 J 1–175（175 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 4 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.60 Å
8Q1P Inward-facing, open2 proteoliposome complex I at 2.9 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 J 1–175（175 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.90 Å
8Q1U Inward-facing, open1 proteoliposome complex I at 3.3 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 J 1–175（175 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 15 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 5 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.30 Å
8Q1Y Outward-facing, open2 proteoliposome complex I at 2.6 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 J 1–175（175 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 ZN ZINC ION × 2 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q25 Outward-facing, open1 proteoliposome complex I at 2.8 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 J 1–175（175 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 ZN ZINC ION × 2 MG MAGNESIUM ION × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.80 Å
8Q45 Inward-facing, closed proteoliposome complex I at 2.7 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 J 1–175（175 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 16 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.70 Å
8Q46 Inward-facing, open2 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 J 1–175（175 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q47 Inward-facing, open1 proteoliposome complex I at 2.9 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 J 1–175（175 aa）	非标准单体：是（mmCIF未提供具体位点）	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 15 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 26 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 5 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.90 Å
8Q48 Outward-facing, closed proteoliposome complex I at 2.5 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 J 1–175（175 aa）	非标准单体：是（mmCIF未提供具体位点）	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 35 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.50 Å
8Q49 Outward-facing, open2 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 J 1–175（175 aa）	非标准单体：是（mmCIF未提供具体位点）	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CHD CHOLIC ACID × 1 ZN ZINC ION × 2 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 FVH [[(2~{R},3~{S},4~{R},5~{R})-5-[(3~{R})-3-aminocarbonylpiperidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{R},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3-oxidanyl-4-phosphonooxy-oxolan-2-yl]methyl hydrogen phosphate × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q4A Outward-facing, open1 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 J 1–175（175 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
9SMF Reduced bovine complex I in lipid nanodisc, NADH-active-Q10 提交 2025-09-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 J 1–175（175 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 20 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 8 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.51 Å
9SMG Reduced bovine complex I in lipid nanodisc, NADH-active-altQ10 提交 2025-09-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 J 1–175（175 aa）	非标准单体：是（mmCIF未提供具体位点）	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 18 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.42 Å
9SMH Reduced bovine complex I in lipid nanodisc, NADH-active-DDM 提交 2025-09-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 J 1–175（175 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 17 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 LMT DODECYL-BETA-D-MALTOSIDE × 1 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.61 Å
9SMI Reduced bovine complex I in lipid nanodisc, NADH-deactive 提交 2025-09-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 J 1–175（175 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 27 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 LMT DODECYL-BETA-D-MALTOSIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 5 CHD CHOLIC ACID × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.01 Å
9W2U Cryo-EM structure of complex I on the bovine heart submitochondrial particles, open 提交 2025-07-28	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 J 1–175（175 aa）	非标准单体：是（mmCIF未提供具体位点）	FME N-FORMYLMETHIONINE × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 18 CDL CARDIOLIPIN × 6 CHD CHOLIC ACID × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.60 Å
9W2V Cryo-EM structure of complex I on the bovine heart submitochondrial particles, closed 提交 2025-07-28	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 J 1–175（175 aa）	非标准单体：是（mmCIF未提供具体位点）	FME N-FORMYLMETHIONINE × 4 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 19 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 12 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 6 MG MAGNESIUM ION × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.80 Å

共 49 个其他 PDB 条目、49 个 assembly。 打开独立比较页并筛选聚集状态

查看构建体与数据证据

UniProt名称	NU6M_BOVIN
Isoform	—
PDB实体	10
链与序列区间	作者链 J； PDB构建体 1–171； UniProt 2–172

NADH-ubiquinone oxidoreductase chain 4L

物种未注明

UniProt P03902

当前结构中的状态

Assembly	聚集状态	构建体	突变与修饰	配体、离子与共同组分	实验方法与环境	结构质量
1	蛋白异源复合物 异源复合物 蛋白 × 45 PDB 声明：45-meric（45） 与蛋白拷贝数一致	链 K； UniProt 2–96	未记录	NADH-ubiquinone oxidoreductase chain 3 × 1 （P03898） NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial × 1 （P42026） NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial × 1 （P23709） NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial × 1 （P17694） NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial × 1 （P04394） NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial × 1 （P25708） ;NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, NDUFS1 ; × 1 （P15690） NADH-ubiquinone oxidoreductase chain 1 × 1 （P03887） NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial × 1 （P42028） NADH-ubiquinone oxidoreductase chain 6 × 1 （P03924） NADH-ubiquinone oxidoreductase chain 5 × 1 （P03920） NADH-ubiquinone oxidoreductase chain 4 × 1 （P03910） NADH-ubiquinone oxidoreductase chain 2 × 1 （P03892） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, NDUFA10,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial ; × 1 （P34942） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial × 1 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial × 1 ;NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial ; × 1 （P23934） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 × 1 （Q02370） Acyl carrier protein, mitochondrial × 1 （P52505） Acyl carrier protein, mitochondrial × 1 （P52505） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 × 1 （P23935） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 × 1 （Q02366） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 ; × 1 （P42029） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 × 1 （Q8HXG6） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 ; × 1 （Q95KV7） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 × 1 （Q02377） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 ; × 1 （Q02371） NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial × 1 （Q02376） ;NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2 ; × 1 （Q02827） NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 × 1 （Q02379） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 × 1 （Q02378） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial × 1 （Q8HXG5） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial ; × 1 （Q02380） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 ; × 1 （Q02367） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, NDUFB2 × 1 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3, NDUFB3 × 1 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, NDUFB8 × 1 ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 ; × 1 （P48305） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 ; × 1 （Q02369） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 × 1 （Q02368） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10, NDUFB10,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10, NDUFB10 ; × 1 （Q02373） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 × 1 （O97725） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7, NDUFA7 × 1 NADH dehydrogenase [ubiquinone] flavoprotein 3, NDUFV3 × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液：pH 8 cryo-EM玻璃化条件：冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 4.35 Å

数据库中的同蛋白其他状态

以下每一行都是同一 UniProt 蛋白在另一个 PDB 条目中的 biological assembly， “相对当前条目”直接指出证据层面的不同；没有差异标签表示当前已读取字段一致。

其他 PDB	相对当前条目 5LC5	Assembly / 聚集状态	构建体	突变与修饰	配体、离子与非聚合物	实验方法与环境	结构质量
5LDW Structure of mammalian respiratory Complex I, class1 提交 2016-06-28	构建体不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 K 1–98（98 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8；20 mM TRIS-HCL, 150 mM NaCl, 0.03% CYMAL-7 cryo-EM玻璃化条件 冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus present in a cold room, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 4.27 Å
5LDX Structure of mammalian respiratory Complex I, class3. 提交 2016-06-28	构建体不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 K 1–98（98 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 20 mM TRIS-HCL, 150 mM NaCl, 0.03% CYMAL-7；pH 8 cryo-EM玻璃化条件 冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 5.60 Å
5O31 Mitochondrial complex I in the deactive state 提交 2017-05-23	构建体不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 K 1–98（98 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.55 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.13 Å
7DGQ Activity optimized supercomplex state1 提交 2020-11-12	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 5 1–98（98 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 CU COPPER (II) ION × 3 HEA HEME-A × 2 MG MAGNESIUM ION × 1 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 UQ2 UBIQUINONE-2 × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 5.00 Å
7DGR Activity optimized supercomplex state2 提交 2020-11-12	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 5 1–98（98 aa）	未记录	FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 3 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.60 Å
7DGS Activity optimized supercomplex state3 提交 2020-11-12	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 5 1–98（98 aa）	未记录	FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 7.80 Å
7DGZ Activity optimized complex I (closed form) 提交 2020-11-12	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 5 1–98（98 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 2 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 3.80 Å
7DH0 Activity optimized complex I (open form) 提交 2020-11-12	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 5 1–98（98 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.20 Å
7DKF Activity optimized supercomplex state4 提交 2020-11-24	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 52 1–98（98 aa）	未记录	HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 8.30 Å
7QSD Bovine complex I in the active state at 3.1 A 提交 2022-01-13	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 K 1–98（98 aa）	非标准单体：是（mmCIF未提供具体位点）	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 13 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 CDL CARDIOLIPIN × 4 LMT DODECYL-BETA-D-MALTOSIDE × 3 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 3.10 Å
7QSK Bovine complex I in lipid nanodisc, Active-Q10 提交 2022-01-13	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 K 1–98（98 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 19 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.84 Å
7QSL Bovine complex I in lipid nanodisc, Active-apo 提交 2022-01-13	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 K 1–98（98 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 20 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 8 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.76 Å
7QSM Bovine complex I in lipid nanodisc, Deactive-ligand (composite) 提交 2022-01-13	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 K 1–98（98 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 GOL GLYCEROL × 1 LMT DODECYL-BETA-D-MALTOSIDE × 1 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.30 Å
7QSN Bovine complex I in lipid nanodisc, Deactive-apo 提交 2022-01-13	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 K 1–98（98 aa）	非标准单体：是（mmCIF未提供具体位点）	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 6 CHD CHOLIC ACID × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.81 Å
7QSO Bovine complex I in lipid nanodisc, State 3 (Slack) 提交 2022-01-13	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 K 1–98（98 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 6 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CHD CHOLIC ACID × 2 CDL CARDIOLIPIN × 6 U10 UBIQUINONE-10 × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 3.02 Å
7R41 Bovine complex I in the presence of IM1761092, active class i (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 K 1–98（98 aa）	非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 16 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R42 Bovine complex I in the presence of IM1761092, active class ii (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 K 1–98（98 aa）	非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 17 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R43 Bovine complex I in the presence of IM1761092, active class iii (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 K 1–98（98 aa）	非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 CDL CARDIOLIPIN × 5 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R44 Bovine complex I in the presence of IM1761092, active class iv (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 K 1–98（98 aa）	非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 11 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R45 Bovine complex I in the presence of IM1761092, deactive class i (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 K 1–98（98 aa）	非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R46 Bovine complex I in the presence of IM1761092, deactive class ii (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 K 1–98（98 aa）	非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 11 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R47 Bovine complex I in the presence of IM1761092, deactive class iii (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 K 1–98（98 aa）	非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R48 Bovine complex I in the presence of IM1761092, deactive class iv (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 K 1–98（98 aa）	非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 15 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 13 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4C Bovine complex I in the presence of IM1761092, deactive class v (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 K 1–98（98 aa）	非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 12 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4D Bovine complex I in the presence of IM1761092, deactive class vi (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 K 1–98（98 aa）	非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4F Bovine complex I in the presence of IM1761092, slack class i (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 K 1–98（98 aa）	非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 7 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 3 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 CDL CARDIOLIPIN × 6 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R4G Bovine complex I in the presence of IM1761092, slack class ii (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 K 1–98（98 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 LMT DODECYL-BETA-D-MALTOSIDE × 10 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.50 Å
8Q0A Inward-facing, closed proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 K 1–98（98 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 16 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 8 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 MG MAGNESIUM ION × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0F Inward-facing, open2 proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 K 1–98（98 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 21 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0J Inward-facing, slack proteoliposome complex I at 3.8 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 K 1–98（98 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 4 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.80 Å
8Q0M Outward-facing, closed proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 K 1–98（98 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0O Outward-facing, open2 proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 K 1–98（98 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0Q Outward-facing, slack proteoliposome complex I at 3.6 A. Initially purified in DDM 提交 2023-07-28	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 K 1–98（98 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 4 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.60 Å
8Q1P Inward-facing, open2 proteoliposome complex I at 2.9 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 K 1–98（98 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.90 Å
8Q1U Inward-facing, open1 proteoliposome complex I at 3.3 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 K 1–98（98 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 15 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 5 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.30 Å
8Q1Y Outward-facing, open2 proteoliposome complex I at 2.6 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 K 1–98（98 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 ZN ZINC ION × 2 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q25 Outward-facing, open1 proteoliposome complex I at 2.8 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 K 1–98（98 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 ZN ZINC ION × 2 MG MAGNESIUM ION × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.80 Å
8Q45 Inward-facing, closed proteoliposome complex I at 2.7 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 K 1–98（98 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 16 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.70 Å
8Q46 Inward-facing, open2 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 K 1–98（98 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q47 Inward-facing, open1 proteoliposome complex I at 2.9 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 K 1–98（98 aa）	非标准单体：是（mmCIF未提供具体位点）	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 15 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 26 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 5 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.90 Å
8Q48 Outward-facing, closed proteoliposome complex I at 2.5 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 K 1–98（98 aa）	非标准单体：是（mmCIF未提供具体位点）	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 35 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.50 Å
8Q49 Outward-facing, open2 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 K 1–98（98 aa）	非标准单体：是（mmCIF未提供具体位点）	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CHD CHOLIC ACID × 1 ZN ZINC ION × 2 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 FVH [[(2~{R},3~{S},4~{R},5~{R})-5-[(3~{R})-3-aminocarbonylpiperidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{R},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3-oxidanyl-4-phosphonooxy-oxolan-2-yl]methyl hydrogen phosphate × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q4A Outward-facing, open1 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 K 1–98（98 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
9SMF Reduced bovine complex I in lipid nanodisc, NADH-active-Q10 提交 2025-09-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 K 1–98（98 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 20 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 8 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.51 Å
9SMG Reduced bovine complex I in lipid nanodisc, NADH-active-altQ10 提交 2025-09-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 K 1–98（98 aa）	非标准单体：是（mmCIF未提供具体位点）	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 18 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.42 Å
9SMH Reduced bovine complex I in lipid nanodisc, NADH-active-DDM 提交 2025-09-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 K 1–98（98 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 17 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 LMT DODECYL-BETA-D-MALTOSIDE × 1 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.61 Å
9SMI Reduced bovine complex I in lipid nanodisc, NADH-deactive 提交 2025-09-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 K 1–98（98 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 27 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 LMT DODECYL-BETA-D-MALTOSIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 5 CHD CHOLIC ACID × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.01 Å

共 47 个其他 PDB 条目、47 个 assembly。 打开独立比较页并筛选聚集状态

查看构建体与数据证据

UniProt名称	NU4LM_BOVIN
Isoform	—
PDB实体	11
链与序列区间	作者链 K； PDB构建体 1–95； UniProt 2–96

NADH-ubiquinone oxidoreductase chain 5

物种未注明

UniProt P03920

当前结构中的状态

Assembly	聚集状态	构建体	突变与修饰	配体、离子与共同组分	实验方法与环境	结构质量
1	蛋白异源复合物 异源复合物 蛋白 × 45 PDB 声明：45-meric（45） 与蛋白拷贝数一致	链 L； UniProt 2–605	未记录	NADH-ubiquinone oxidoreductase chain 3 × 1 （P03898） NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial × 1 （P42026） NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial × 1 （P23709） NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial × 1 （P17694） NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial × 1 （P04394） NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial × 1 （P25708） ;NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, NDUFS1 ; × 1 （P15690） NADH-ubiquinone oxidoreductase chain 1 × 1 （P03887） NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial × 1 （P42028） NADH-ubiquinone oxidoreductase chain 6 × 1 （P03924） NADH-ubiquinone oxidoreductase chain 4L × 1 （P03902） NADH-ubiquinone oxidoreductase chain 4 × 1 （P03910） NADH-ubiquinone oxidoreductase chain 2 × 1 （P03892） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, NDUFA10,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial ; × 1 （P34942） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial × 1 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial × 1 ;NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial ; × 1 （P23934） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 × 1 （Q02370） Acyl carrier protein, mitochondrial × 1 （P52505） Acyl carrier protein, mitochondrial × 1 （P52505） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 × 1 （P23935） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 × 1 （Q02366） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 ; × 1 （P42029） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 × 1 （Q8HXG6） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 ; × 1 （Q95KV7） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 × 1 （Q02377） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 ; × 1 （Q02371） NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial × 1 （Q02376） ;NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2 ; × 1 （Q02827） NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 × 1 （Q02379） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 × 1 （Q02378） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial × 1 （Q8HXG5） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial ; × 1 （Q02380） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 ; × 1 （Q02367） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, NDUFB2 × 1 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3, NDUFB3 × 1 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, NDUFB8 × 1 ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 ; × 1 （P48305） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 ; × 1 （Q02369） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 × 1 （Q02368） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10, NDUFB10,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10, NDUFB10 ; × 1 （Q02373） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 × 1 （O97725） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7, NDUFA7 × 1 NADH dehydrogenase [ubiquinone] flavoprotein 3, NDUFV3 × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液：pH 8 cryo-EM玻璃化条件：冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 4.35 Å

数据库中的同蛋白其他状态

以下每一行都是同一 UniProt 蛋白在另一个 PDB 条目中的 biological assembly， “相对当前条目”直接指出证据层面的不同；没有差异标签表示当前已读取字段一致。

其他 PDB	相对当前条目 5LC5	Assembly / 聚集状态	构建体	突变与修饰	配体、离子与非聚合物	实验方法与环境	结构质量
5LDW Structure of mammalian respiratory Complex I, class1 提交 2016-06-28	构建体不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 L 1–606（606 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8；20 mM TRIS-HCL, 150 mM NaCl, 0.03% CYMAL-7 cryo-EM玻璃化条件 冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus present in a cold room, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 4.27 Å
5LDX Structure of mammalian respiratory Complex I, class3. 提交 2016-06-28	构建体不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 L 1–606（606 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 20 mM TRIS-HCL, 150 mM NaCl, 0.03% CYMAL-7；pH 8 cryo-EM玻璃化条件 冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 5.60 Å
5O31 Mitochondrial complex I in the deactive state 提交 2017-05-23	构建体不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 L 1–606（606 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.55 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.13 Å
7DGQ Activity optimized supercomplex state1 提交 2020-11-12	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 6 1–606（606 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 CU COPPER (II) ION × 3 HEA HEME-A × 2 MG MAGNESIUM ION × 1 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 UQ2 UBIQUINONE-2 × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 5.00 Å
7DGR Activity optimized supercomplex state2 提交 2020-11-12	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 6 1–606（606 aa）	未记录	FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 3 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.60 Å
7DGS Activity optimized supercomplex state3 提交 2020-11-12	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 6 1–606（606 aa）	未记录	FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 7.80 Å
7DGZ Activity optimized complex I (closed form) 提交 2020-11-12	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 6 1–606（606 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 2 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 3.80 Å
7DH0 Activity optimized complex I (open form) 提交 2020-11-12	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 6 1–606（606 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.20 Å
7DKF Activity optimized supercomplex state4 提交 2020-11-24	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 62 1–606（606 aa）	未记录	HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 8.30 Å
7QSD Bovine complex I in the active state at 3.1 A 提交 2022-01-13	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 L 1–606（606 aa）	非标准单体：是（mmCIF未提供具体位点）	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 13 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 CDL CARDIOLIPIN × 4 LMT DODECYL-BETA-D-MALTOSIDE × 3 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 3.10 Å
7QSK Bovine complex I in lipid nanodisc, Active-Q10 提交 2022-01-13	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 L 1–606（606 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 19 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.84 Å
7QSL Bovine complex I in lipid nanodisc, Active-apo 提交 2022-01-13	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 L 1–606（606 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 20 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 8 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.76 Å
7QSM Bovine complex I in lipid nanodisc, Deactive-ligand (composite) 提交 2022-01-13	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 L 1–606（606 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 GOL GLYCEROL × 1 LMT DODECYL-BETA-D-MALTOSIDE × 1 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.30 Å
7QSN Bovine complex I in lipid nanodisc, Deactive-apo 提交 2022-01-13	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 L 1–606（606 aa）	非标准单体：是（mmCIF未提供具体位点）	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 6 CHD CHOLIC ACID × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.81 Å
7QSO Bovine complex I in lipid nanodisc, State 3 (Slack) 提交 2022-01-13	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 L 1–606（606 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 6 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CHD CHOLIC ACID × 2 CDL CARDIOLIPIN × 6 U10 UBIQUINONE-10 × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 3.02 Å
7R41 Bovine complex I in the presence of IM1761092, active class i (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 L 1–606（606 aa）	非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 16 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R42 Bovine complex I in the presence of IM1761092, active class ii (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 L 1–606（606 aa）	非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 17 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R43 Bovine complex I in the presence of IM1761092, active class iii (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 L 1–606（606 aa）	非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 CDL CARDIOLIPIN × 5 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R44 Bovine complex I in the presence of IM1761092, active class iv (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 L 1–606（606 aa）	非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 11 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R45 Bovine complex I in the presence of IM1761092, deactive class i (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 L 1–606（606 aa）	非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R46 Bovine complex I in the presence of IM1761092, deactive class ii (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 L 1–606（606 aa）	非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 11 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R47 Bovine complex I in the presence of IM1761092, deactive class iii (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 L 1–606（606 aa）	非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R48 Bovine complex I in the presence of IM1761092, deactive class iv (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 L 1–606（606 aa）	非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 15 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 13 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4C Bovine complex I in the presence of IM1761092, deactive class v (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 L 1–606（606 aa）	非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 12 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4D Bovine complex I in the presence of IM1761092, deactive class vi (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 L 1–606（606 aa）	非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4F Bovine complex I in the presence of IM1761092, slack class i (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 L 1–606（606 aa）	非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 7 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 3 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 CDL CARDIOLIPIN × 6 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R4G Bovine complex I in the presence of IM1761092, slack class ii (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 L 1–606（606 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 LMT DODECYL-BETA-D-MALTOSIDE × 10 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.50 Å
8Q0A Inward-facing, closed proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 L 1–606（606 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 16 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 8 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 MG MAGNESIUM ION × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0F Inward-facing, open2 proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 L 1–606（606 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 21 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0J Inward-facing, slack proteoliposome complex I at 3.8 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 L 1–606（606 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 4 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.80 Å
8Q0M Outward-facing, closed proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 L 1–606（606 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0O Outward-facing, open2 proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 L 1–606（606 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0Q Outward-facing, slack proteoliposome complex I at 3.6 A. Initially purified in DDM 提交 2023-07-28	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 L 1–606（606 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 4 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.60 Å
8Q1P Inward-facing, open2 proteoliposome complex I at 2.9 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 L 1–606（606 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.90 Å
8Q1U Inward-facing, open1 proteoliposome complex I at 3.3 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 L 1–606（606 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 15 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 5 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.30 Å
8Q1Y Outward-facing, open2 proteoliposome complex I at 2.6 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 L 1–606（606 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 ZN ZINC ION × 2 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q25 Outward-facing, open1 proteoliposome complex I at 2.8 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 L 1–606（606 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 ZN ZINC ION × 2 MG MAGNESIUM ION × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.80 Å
8Q45 Inward-facing, closed proteoliposome complex I at 2.7 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 L 1–606（606 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 16 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.70 Å
8Q46 Inward-facing, open2 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 L 1–606（606 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q47 Inward-facing, open1 proteoliposome complex I at 2.9 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 L 1–606（606 aa）	非标准单体：是（mmCIF未提供具体位点）	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 15 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 26 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 5 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.90 Å
8Q48 Outward-facing, closed proteoliposome complex I at 2.5 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 L 1–606（606 aa）	非标准单体：是（mmCIF未提供具体位点）	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 35 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.50 Å
8Q49 Outward-facing, open2 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 L 1–606（606 aa）	非标准单体：是（mmCIF未提供具体位点）	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CHD CHOLIC ACID × 1 ZN ZINC ION × 2 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 FVH [[(2~{R},3~{S},4~{R},5~{R})-5-[(3~{R})-3-aminocarbonylpiperidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{R},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3-oxidanyl-4-phosphonooxy-oxolan-2-yl]methyl hydrogen phosphate × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q4A Outward-facing, open1 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 L 1–606（606 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
9SMF Reduced bovine complex I in lipid nanodisc, NADH-active-Q10 提交 2025-09-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 L 1–606（606 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 20 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 8 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.51 Å
9SMG Reduced bovine complex I in lipid nanodisc, NADH-active-altQ10 提交 2025-09-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 L 1–606（606 aa）	非标准单体：是（mmCIF未提供具体位点）	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 18 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.42 Å
9SMH Reduced bovine complex I in lipid nanodisc, NADH-active-DDM 提交 2025-09-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 L 1–606（606 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 17 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 LMT DODECYL-BETA-D-MALTOSIDE × 1 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.61 Å
9SMI Reduced bovine complex I in lipid nanodisc, NADH-deactive 提交 2025-09-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 L 1–606（606 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 27 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 LMT DODECYL-BETA-D-MALTOSIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 5 CHD CHOLIC ACID × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.01 Å
9W2U Cryo-EM structure of complex I on the bovine heart submitochondrial particles, open 提交 2025-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 L 2–606（605 aa）	未记录	FME N-FORMYLMETHIONINE × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 18 CDL CARDIOLIPIN × 6 CHD CHOLIC ACID × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.60 Å
9W2V Cryo-EM structure of complex I on the bovine heart submitochondrial particles, closed 提交 2025-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 L 2–606（605 aa）	未记录	FME N-FORMYLMETHIONINE × 4 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 19 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 12 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 6 MG MAGNESIUM ION × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.80 Å

共 49 个其他 PDB 条目、49 个 assembly。 打开独立比较页并筛选聚集状态

查看构建体与数据证据

UniProt名称	NU5M_BOVIN
Isoform	—
PDB实体	12
链与序列区间	作者链 L； PDB构建体 1–604； UniProt 2–605

NADH-ubiquinone oxidoreductase chain 4

物种未注明

UniProt P03910

当前结构中的状态

Assembly	聚集状态	构建体	突变与修饰	配体、离子与共同组分	实验方法与环境	结构质量
1	蛋白异源复合物 异源复合物 蛋白 × 45 PDB 声明：45-meric（45） 与蛋白拷贝数一致	链 M； UniProt 3–459	未记录	NADH-ubiquinone oxidoreductase chain 3 × 1 （P03898） NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial × 1 （P42026） NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial × 1 （P23709） NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial × 1 （P17694） NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial × 1 （P04394） NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial × 1 （P25708） ;NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, NDUFS1 ; × 1 （P15690） NADH-ubiquinone oxidoreductase chain 1 × 1 （P03887） NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial × 1 （P42028） NADH-ubiquinone oxidoreductase chain 6 × 1 （P03924） NADH-ubiquinone oxidoreductase chain 4L × 1 （P03902） NADH-ubiquinone oxidoreductase chain 5 × 1 （P03920） NADH-ubiquinone oxidoreductase chain 2 × 1 （P03892） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, NDUFA10,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial ; × 1 （P34942） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial × 1 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial × 1 ;NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial ; × 1 （P23934） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 × 1 （Q02370） Acyl carrier protein, mitochondrial × 1 （P52505） Acyl carrier protein, mitochondrial × 1 （P52505） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 × 1 （P23935） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 × 1 （Q02366） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 ; × 1 （P42029） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 × 1 （Q8HXG6） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 ; × 1 （Q95KV7） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 × 1 （Q02377） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 ; × 1 （Q02371） NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial × 1 （Q02376） ;NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2 ; × 1 （Q02827） NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 × 1 （Q02379） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 × 1 （Q02378） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial × 1 （Q8HXG5） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial ; × 1 （Q02380） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 ; × 1 （Q02367） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, NDUFB2 × 1 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3, NDUFB3 × 1 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, NDUFB8 × 1 ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 ; × 1 （P48305） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 ; × 1 （Q02369） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 × 1 （Q02368） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10, NDUFB10,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10, NDUFB10 ; × 1 （Q02373） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 × 1 （O97725） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7, NDUFA7 × 1 NADH dehydrogenase [ubiquinone] flavoprotein 3, NDUFV3 × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液：pH 8 cryo-EM玻璃化条件：冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 4.35 Å

数据库中的同蛋白其他状态

以下每一行都是同一 UniProt 蛋白在另一个 PDB 条目中的 biological assembly， “相对当前条目”直接指出证据层面的不同；没有差异标签表示当前已读取字段一致。

其他 PDB	相对当前条目 5LC5	Assembly / 聚集状态	构建体	突变与修饰	配体、离子与非聚合物	实验方法与环境	结构质量
5LDW Structure of mammalian respiratory Complex I, class1 提交 2016-06-28	构建体不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 M 1–459（459 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8；20 mM TRIS-HCL, 150 mM NaCl, 0.03% CYMAL-7 cryo-EM玻璃化条件 冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus present in a cold room, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 4.27 Å
5LDX Structure of mammalian respiratory Complex I, class3. 提交 2016-06-28	构建体不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 M 1–459（459 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 20 mM TRIS-HCL, 150 mM NaCl, 0.03% CYMAL-7；pH 8 cryo-EM玻璃化条件 冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 5.60 Å
5O31 Mitochondrial complex I in the deactive state 提交 2017-05-23	构建体不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 M 1–459（459 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.55 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.13 Å
7DGQ Activity optimized supercomplex state1 提交 2020-11-12	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 4 1–459（459 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 CU COPPER (II) ION × 3 HEA HEME-A × 2 MG MAGNESIUM ION × 1 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 UQ2 UBIQUINONE-2 × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 5.00 Å
7DGR Activity optimized supercomplex state2 提交 2020-11-12	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 4 1–459（459 aa）	未记录	FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 3 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.60 Å
7DGS Activity optimized supercomplex state3 提交 2020-11-12	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 4 1–459（459 aa）	未记录	FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 7.80 Å
7DGZ Activity optimized complex I (closed form) 提交 2020-11-12	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 4 1–459（459 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 2 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 3.80 Å
7DH0 Activity optimized complex I (open form) 提交 2020-11-12	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 4 1–459（459 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.20 Å
7DKF Activity optimized supercomplex state4 提交 2020-11-24	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 42 1–459（459 aa）	未记录	HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 8.30 Å
7QSD Bovine complex I in the active state at 3.1 A 提交 2022-01-13	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 M 1–459（459 aa）	非标准单体：是（mmCIF未提供具体位点）	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 13 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 CDL CARDIOLIPIN × 4 LMT DODECYL-BETA-D-MALTOSIDE × 3 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 3.10 Å
7QSK Bovine complex I in lipid nanodisc, Active-Q10 提交 2022-01-13	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 M 1–459（459 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 19 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.84 Å
7QSL Bovine complex I in lipid nanodisc, Active-apo 提交 2022-01-13	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 M 1–459（459 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 20 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 8 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.76 Å
7QSM Bovine complex I in lipid nanodisc, Deactive-ligand (composite) 提交 2022-01-13	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 M 1–459（459 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 GOL GLYCEROL × 1 LMT DODECYL-BETA-D-MALTOSIDE × 1 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.30 Å
7QSN Bovine complex I in lipid nanodisc, Deactive-apo 提交 2022-01-13	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 M 1–459（459 aa）	非标准单体：是（mmCIF未提供具体位点）	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 6 CHD CHOLIC ACID × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.81 Å
7QSO Bovine complex I in lipid nanodisc, State 3 (Slack) 提交 2022-01-13	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 M 1–459（459 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 6 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CHD CHOLIC ACID × 2 CDL CARDIOLIPIN × 6 U10 UBIQUINONE-10 × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 3.02 Å
7R41 Bovine complex I in the presence of IM1761092, active class i (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 M 1–459（459 aa）	非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 16 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R42 Bovine complex I in the presence of IM1761092, active class ii (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 M 1–459（459 aa）	非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 17 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R43 Bovine complex I in the presence of IM1761092, active class iii (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 M 1–459（459 aa）	非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 CDL CARDIOLIPIN × 5 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R44 Bovine complex I in the presence of IM1761092, active class iv (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 M 1–459（459 aa）	非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 11 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R45 Bovine complex I in the presence of IM1761092, deactive class i (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 M 1–459（459 aa）	非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R46 Bovine complex I in the presence of IM1761092, deactive class ii (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 M 1–459（459 aa）	非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 11 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R47 Bovine complex I in the presence of IM1761092, deactive class iii (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 M 1–459（459 aa）	非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R48 Bovine complex I in the presence of IM1761092, deactive class iv (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 M 1–459（459 aa）	非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 15 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 13 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4C Bovine complex I in the presence of IM1761092, deactive class v (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 M 1–459（459 aa）	非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 12 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4D Bovine complex I in the presence of IM1761092, deactive class vi (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 M 1–459（459 aa）	非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4F Bovine complex I in the presence of IM1761092, slack class i (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 M 1–459（459 aa）	非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 7 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 3 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 CDL CARDIOLIPIN × 6 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R4G Bovine complex I in the presence of IM1761092, slack class ii (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 M 1–459（459 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 LMT DODECYL-BETA-D-MALTOSIDE × 10 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.50 Å
8Q0A Inward-facing, closed proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 M 1–459（459 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 16 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 8 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 MG MAGNESIUM ION × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0F Inward-facing, open2 proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 M 1–459（459 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 21 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0J Inward-facing, slack proteoliposome complex I at 3.8 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 M 1–459（459 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 4 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.80 Å
8Q0M Outward-facing, closed proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 M 1–459（459 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0O Outward-facing, open2 proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 M 1–459（459 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0Q Outward-facing, slack proteoliposome complex I at 3.6 A. Initially purified in DDM 提交 2023-07-28	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 M 1–459（459 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 4 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.60 Å
8Q1P Inward-facing, open2 proteoliposome complex I at 2.9 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 M 1–459（459 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.90 Å
8Q1U Inward-facing, open1 proteoliposome complex I at 3.3 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 M 1–459（459 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 15 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 5 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.30 Å
8Q1Y Outward-facing, open2 proteoliposome complex I at 2.6 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 M 1–459（459 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 ZN ZINC ION × 2 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q25 Outward-facing, open1 proteoliposome complex I at 2.8 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 M 1–459（459 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 ZN ZINC ION × 2 MG MAGNESIUM ION × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.80 Å
8Q45 Inward-facing, closed proteoliposome complex I at 2.7 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 M 1–459（459 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 16 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.70 Å
8Q46 Inward-facing, open2 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 M 1–459（459 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q47 Inward-facing, open1 proteoliposome complex I at 2.9 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 M 1–459（459 aa）	非标准单体：是（mmCIF未提供具体位点）	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 15 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 26 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 5 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.90 Å
8Q48 Outward-facing, closed proteoliposome complex I at 2.5 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 M 1–459（459 aa）	非标准单体：是（mmCIF未提供具体位点）	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 35 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.50 Å
8Q49 Outward-facing, open2 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 M 1–459（459 aa）	非标准单体：是（mmCIF未提供具体位点）	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CHD CHOLIC ACID × 1 ZN ZINC ION × 2 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 FVH [[(2~{R},3~{S},4~{R},5~{R})-5-[(3~{R})-3-aminocarbonylpiperidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{R},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3-oxidanyl-4-phosphonooxy-oxolan-2-yl]methyl hydrogen phosphate × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q4A Outward-facing, open1 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 M 1–459（459 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
9SMF Reduced bovine complex I in lipid nanodisc, NADH-active-Q10 提交 2025-09-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 M 1–459（459 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 20 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 8 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.51 Å
9SMG Reduced bovine complex I in lipid nanodisc, NADH-active-altQ10 提交 2025-09-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 M 1–459（459 aa）	非标准单体：是（mmCIF未提供具体位点）	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 18 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.42 Å
9SMH Reduced bovine complex I in lipid nanodisc, NADH-active-DDM 提交 2025-09-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 M 1–459（459 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 17 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 LMT DODECYL-BETA-D-MALTOSIDE × 1 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.61 Å
9SMI Reduced bovine complex I in lipid nanodisc, NADH-deactive 提交 2025-09-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 M 1–459（459 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 27 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 LMT DODECYL-BETA-D-MALTOSIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 5 CHD CHOLIC ACID × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.01 Å
9W2U Cryo-EM structure of complex I on the bovine heart submitochondrial particles, open 提交 2025-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 M 2–459（458 aa）	未记录	FME N-FORMYLMETHIONINE × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 18 CDL CARDIOLIPIN × 6 CHD CHOLIC ACID × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.60 Å
9W2V Cryo-EM structure of complex I on the bovine heart submitochondrial particles, closed 提交 2025-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 M 2–459（458 aa）	未记录	FME N-FORMYLMETHIONINE × 4 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 19 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 12 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 6 MG MAGNESIUM ION × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.80 Å

共 49 个其他 PDB 条目、49 个 assembly。 打开独立比较页并筛选聚集状态

查看构建体与数据证据

UniProt名称	NU4M_BOVIN
Isoform	—
PDB实体	13
链与序列区间	作者链 M； PDB构建体 1–457； UniProt 3–459

NADH-ubiquinone oxidoreductase chain 2

物种未注明

UniProt P03892

当前结构中的状态

Assembly	聚集状态	构建体	突变与修饰	配体、离子与共同组分	实验方法与环境	结构质量
1	蛋白异源复合物 异源复合物 蛋白 × 45 PDB 声明：45-meric（45） 与蛋白拷贝数一致	链 N； UniProt 2–345	未记录	NADH-ubiquinone oxidoreductase chain 3 × 1 （P03898） NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial × 1 （P42026） NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial × 1 （P23709） NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial × 1 （P17694） NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial × 1 （P04394） NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial × 1 （P25708） ;NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, NDUFS1 ; × 1 （P15690） NADH-ubiquinone oxidoreductase chain 1 × 1 （P03887） NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial × 1 （P42028） NADH-ubiquinone oxidoreductase chain 6 × 1 （P03924） NADH-ubiquinone oxidoreductase chain 4L × 1 （P03902） NADH-ubiquinone oxidoreductase chain 5 × 1 （P03920） NADH-ubiquinone oxidoreductase chain 4 × 1 （P03910） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, NDUFA10,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial ; × 1 （P34942） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial × 1 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial × 1 ;NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial ; × 1 （P23934） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 × 1 （Q02370） Acyl carrier protein, mitochondrial × 1 （P52505） Acyl carrier protein, mitochondrial × 1 （P52505） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 × 1 （P23935） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 × 1 （Q02366） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 ; × 1 （P42029） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 × 1 （Q8HXG6） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 ; × 1 （Q95KV7） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 × 1 （Q02377） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 ; × 1 （Q02371） NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial × 1 （Q02376） ;NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2 ; × 1 （Q02827） NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 × 1 （Q02379） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 × 1 （Q02378） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial × 1 （Q8HXG5） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial ; × 1 （Q02380） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 ; × 1 （Q02367） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, NDUFB2 × 1 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3, NDUFB3 × 1 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, NDUFB8 × 1 ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 ; × 1 （P48305） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 ; × 1 （Q02369） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 × 1 （Q02368） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10, NDUFB10,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10, NDUFB10 ; × 1 （Q02373） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 × 1 （O97725） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7, NDUFA7 × 1 NADH dehydrogenase [ubiquinone] flavoprotein 3, NDUFV3 × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液：pH 8 cryo-EM玻璃化条件：冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 4.35 Å

数据库中的同蛋白其他状态

以下每一行都是同一 UniProt 蛋白在另一个 PDB 条目中的 biological assembly， “相对当前条目”直接指出证据层面的不同；没有差异标签表示当前已读取字段一致。

其他 PDB	相对当前条目 5LC5	Assembly / 聚集状态	构建体	突变与修饰	配体、离子与非聚合物	实验方法与环境	结构质量
5LDW Structure of mammalian respiratory Complex I, class1 提交 2016-06-28	构建体不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 N 1–347（347 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8；20 mM TRIS-HCL, 150 mM NaCl, 0.03% CYMAL-7 cryo-EM玻璃化条件 冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus present in a cold room, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 4.27 Å
5LDX Structure of mammalian respiratory Complex I, class3. 提交 2016-06-28	构建体不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 N 1–347（347 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 20 mM TRIS-HCL, 150 mM NaCl, 0.03% CYMAL-7；pH 8 cryo-EM玻璃化条件 冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 5.60 Å
5O31 Mitochondrial complex I in the deactive state 提交 2017-05-23	构建体不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 N 1–347（347 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.55 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.13 Å
7DGQ Activity optimized supercomplex state1 提交 2020-11-12	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 2 1–347（347 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 CU COPPER (II) ION × 3 HEA HEME-A × 2 MG MAGNESIUM ION × 1 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 UQ2 UBIQUINONE-2 × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 5.00 Å
7DGR Activity optimized supercomplex state2 提交 2020-11-12	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 2 1–347（347 aa）	未记录	FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 3 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.60 Å
7DGS Activity optimized supercomplex state3 提交 2020-11-12	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 2 1–347（347 aa）	未记录	FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 7.80 Å
7DGZ Activity optimized complex I (closed form) 提交 2020-11-12	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 2 1–347（347 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 2 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 3.80 Å
7DH0 Activity optimized complex I (open form) 提交 2020-11-12	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 2 1–347（347 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.20 Å
7DKF Activity optimized supercomplex state4 提交 2020-11-24	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 22 1–347（347 aa）	未记录	HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 8.30 Å
7QSD Bovine complex I in the active state at 3.1 A 提交 2022-01-13	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 N 1–347（347 aa）	非标准单体：是（mmCIF未提供具体位点）	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 13 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 CDL CARDIOLIPIN × 4 LMT DODECYL-BETA-D-MALTOSIDE × 3 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 3.10 Å
7QSK Bovine complex I in lipid nanodisc, Active-Q10 提交 2022-01-13	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 N 1–347（347 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 19 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.84 Å
7QSL Bovine complex I in lipid nanodisc, Active-apo 提交 2022-01-13	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 N 1–347（347 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 20 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 8 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.76 Å
7QSM Bovine complex I in lipid nanodisc, Deactive-ligand (composite) 提交 2022-01-13	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 N 1–347（347 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 GOL GLYCEROL × 1 LMT DODECYL-BETA-D-MALTOSIDE × 1 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.30 Å
7QSN Bovine complex I in lipid nanodisc, Deactive-apo 提交 2022-01-13	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 N 1–347（347 aa）	非标准单体：是（mmCIF未提供具体位点）	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 6 CHD CHOLIC ACID × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.81 Å
7QSO Bovine complex I in lipid nanodisc, State 3 (Slack) 提交 2022-01-13	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 N 1–347（347 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 6 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CHD CHOLIC ACID × 2 CDL CARDIOLIPIN × 6 U10 UBIQUINONE-10 × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 3.02 Å
7R41 Bovine complex I in the presence of IM1761092, active class i (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 N 1–347（347 aa）	非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 16 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R42 Bovine complex I in the presence of IM1761092, active class ii (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 N 1–347（347 aa）	非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 17 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R43 Bovine complex I in the presence of IM1761092, active class iii (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 N 1–347（347 aa）	突变：N278K 非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 CDL CARDIOLIPIN × 5 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R44 Bovine complex I in the presence of IM1761092, active class iv (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 N 1–347（347 aa）	非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 11 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R45 Bovine complex I in the presence of IM1761092, deactive class i (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 N 1–347（347 aa）	非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R46 Bovine complex I in the presence of IM1761092, deactive class ii (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 N 1–347（347 aa）	非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 11 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R47 Bovine complex I in the presence of IM1761092, deactive class iii (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 N 1–347（347 aa）	非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R48 Bovine complex I in the presence of IM1761092, deactive class iv (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 N 1–347（347 aa）	非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 15 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 13 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4C Bovine complex I in the presence of IM1761092, deactive class v (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 N 1–347（347 aa）	非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 12 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4D Bovine complex I in the presence of IM1761092, deactive class vi (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 N 1–347（347 aa）	非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4F Bovine complex I in the presence of IM1761092, slack class i (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 N 1–347（347 aa）	非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 7 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 3 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 CDL CARDIOLIPIN × 6 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R4G Bovine complex I in the presence of IM1761092, slack class ii (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 N 1–347（347 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 LMT DODECYL-BETA-D-MALTOSIDE × 10 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.50 Å
8Q0A Inward-facing, closed proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 N 1–347（347 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 16 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 8 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 MG MAGNESIUM ION × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0F Inward-facing, open2 proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 N 1–347（347 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 21 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0J Inward-facing, slack proteoliposome complex I at 3.8 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 N 1–347（347 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 4 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.80 Å
8Q0M Outward-facing, closed proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 N 1–347（347 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0O Outward-facing, open2 proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 N 1–347（347 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0Q Outward-facing, slack proteoliposome complex I at 3.6 A. Initially purified in DDM 提交 2023-07-28	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 N 1–347（347 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 4 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.60 Å
8Q1P Inward-facing, open2 proteoliposome complex I at 2.9 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 N 1–347（347 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.90 Å
8Q1U Inward-facing, open1 proteoliposome complex I at 3.3 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 N 1–347（347 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 15 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 5 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.30 Å
8Q1Y Outward-facing, open2 proteoliposome complex I at 2.6 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 N 1–347（347 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 ZN ZINC ION × 2 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q25 Outward-facing, open1 proteoliposome complex I at 2.8 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 N 1–347（347 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 ZN ZINC ION × 2 MG MAGNESIUM ION × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.80 Å
8Q45 Inward-facing, closed proteoliposome complex I at 2.7 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 N 1–347（347 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 16 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.70 Å
8Q46 Inward-facing, open2 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 N 1–347（347 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q47 Inward-facing, open1 proteoliposome complex I at 2.9 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 N 1–347（347 aa）	非标准单体：是（mmCIF未提供具体位点）	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 15 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 26 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 5 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.90 Å
8Q48 Outward-facing, closed proteoliposome complex I at 2.5 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 N 1–347（347 aa）	非标准单体：是（mmCIF未提供具体位点）	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 35 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.50 Å
8Q49 Outward-facing, open2 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 N 1–347（347 aa）	非标准单体：是（mmCIF未提供具体位点）	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CHD CHOLIC ACID × 1 ZN ZINC ION × 2 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 FVH [[(2~{R},3~{S},4~{R},5~{R})-5-[(3~{R})-3-aminocarbonylpiperidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{R},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3-oxidanyl-4-phosphonooxy-oxolan-2-yl]methyl hydrogen phosphate × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q4A Outward-facing, open1 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 N 1–347（347 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
9SMF Reduced bovine complex I in lipid nanodisc, NADH-active-Q10 提交 2025-09-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 N 1–347（347 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 20 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 8 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.51 Å
9SMG Reduced bovine complex I in lipid nanodisc, NADH-active-altQ10 提交 2025-09-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 N 1–347（347 aa）	非标准单体：是（mmCIF未提供具体位点）	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 18 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.42 Å
9SMH Reduced bovine complex I in lipid nanodisc, NADH-active-DDM 提交 2025-09-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 N 1–347（347 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 17 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 LMT DODECYL-BETA-D-MALTOSIDE × 1 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.61 Å
9SMI Reduced bovine complex I in lipid nanodisc, NADH-deactive 提交 2025-09-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 N 1–347（347 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 27 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 LMT DODECYL-BETA-D-MALTOSIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 5 CHD CHOLIC ACID × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.01 Å
9W2U Cryo-EM structure of complex I on the bovine heart submitochondrial particles, open 提交 2025-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 N 2–347（346 aa）	未记录	FME N-FORMYLMETHIONINE × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 18 CDL CARDIOLIPIN × 6 CHD CHOLIC ACID × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.60 Å
9W2V Cryo-EM structure of complex I on the bovine heart submitochondrial particles, closed 提交 2025-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 N 2–347（346 aa）	未记录	FME N-FORMYLMETHIONINE × 4 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 19 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 12 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 6 MG MAGNESIUM ION × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.80 Å

共 49 个其他 PDB 条目、49 个 assembly。 打开独立比较页并筛选聚集状态

查看构建体与数据证据

UniProt名称	NU2M_BOVIN
Isoform	—
PDB实体	14
链与序列区间	作者链 N； PDB构建体 1–344； UniProt 2–345

;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, NDUFA10,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial ;

物种未注明

UniProt P34942

当前结构中的状态

Assembly	聚集状态	构建体	突变与修饰	配体、离子与共同组分	实验方法与环境	结构质量
1	蛋白异源复合物 异源复合物 蛋白 × 45 PDB 声明：45-meric（45） 与蛋白拷贝数一致	链 O； UniProt 114–341	未记录	NADH-ubiquinone oxidoreductase chain 3 × 1 （P03898） NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial × 1 （P42026） NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial × 1 （P23709） NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial × 1 （P17694） NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial × 1 （P04394） NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial × 1 （P25708） ;NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, NDUFS1 ; × 1 （P15690） NADH-ubiquinone oxidoreductase chain 1 × 1 （P03887） NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial × 1 （P42028） NADH-ubiquinone oxidoreductase chain 6 × 1 （P03924） NADH-ubiquinone oxidoreductase chain 4L × 1 （P03902） NADH-ubiquinone oxidoreductase chain 5 × 1 （P03920） NADH-ubiquinone oxidoreductase chain 4 × 1 （P03910） NADH-ubiquinone oxidoreductase chain 2 × 1 （P03892） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial × 1 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial × 1 ;NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial ; × 1 （P23934） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 × 1 （Q02370） Acyl carrier protein, mitochondrial × 1 （P52505） Acyl carrier protein, mitochondrial × 1 （P52505） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 × 1 （P23935） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 × 1 （Q02366） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 ; × 1 （P42029） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 × 1 （Q8HXG6） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 ; × 1 （Q95KV7） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 × 1 （Q02377） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 ; × 1 （Q02371） NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial × 1 （Q02376） ;NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2 ; × 1 （Q02827） NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 × 1 （Q02379） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 × 1 （Q02378） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial × 1 （Q8HXG5） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial ; × 1 （Q02380） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 ; × 1 （Q02367） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, NDUFB2 × 1 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3, NDUFB3 × 1 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, NDUFB8 × 1 ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 ; × 1 （P48305） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 ; × 1 （Q02369） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 × 1 （Q02368） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10, NDUFB10,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10, NDUFB10 ; × 1 （Q02373） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 × 1 （O97725） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7, NDUFA7 × 1 NADH dehydrogenase [ubiquinone] flavoprotein 3, NDUFV3 × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液：pH 8 cryo-EM玻璃化条件：冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 4.35 Å

数据库中的同蛋白其他状态

以下每一行都是同一 UniProt 蛋白在另一个 PDB 条目中的 biological assembly， “相对当前条目”直接指出证据层面的不同；没有差异标签表示当前已读取字段一致。

其他 PDB	相对当前条目 5LC5	Assembly / 聚集状态	构建体	突变与修饰	配体、离子与非聚合物	实验方法与环境	结构质量
5LDW Structure of mammalian respiratory Complex I, class1 提交 2016-06-28	构建体不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 O 114–343（230 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8；20 mM TRIS-HCL, 150 mM NaCl, 0.03% CYMAL-7 cryo-EM玻璃化条件 冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus present in a cold room, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 4.27 Å
5LDX Structure of mammalian respiratory Complex I, class3. 提交 2016-06-28	结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 O 114–341（228 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 20 mM TRIS-HCL, 150 mM NaCl, 0.03% CYMAL-7；pH 8 cryo-EM玻璃化条件 冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 5.60 Å
5O31 Mitochondrial complex I in the deactive state 提交 2017-05-23	构建体不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 O 24–343（320 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.55 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.13 Å
7DGQ Activity optimized supercomplex state1 提交 2020-11-12	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 S 24–343（320 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 CU COPPER (II) ION × 3 HEA HEME-A × 2 MG MAGNESIUM ION × 1 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 UQ2 UBIQUINONE-2 × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 5.00 Å
7DGR Activity optimized supercomplex state2 提交 2020-11-12	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 S 24–343（320 aa）	未记录	FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 3 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.60 Å
7DGS Activity optimized supercomplex state3 提交 2020-11-12	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 S 24–343（320 aa）	未记录	FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 7.80 Å
7DGZ Activity optimized complex I (closed form) 提交 2020-11-12	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 S 24–343（320 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 2 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 3.80 Å
7DH0 Activity optimized complex I (open form) 提交 2020-11-12	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 S 24–343（320 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.20 Å
7DKF Activity optimized supercomplex state4 提交 2020-11-24	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 S2 24–343（320 aa）	未记录	HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 8.30 Å
7QSD Bovine complex I in the active state at 3.1 A 提交 2022-01-13	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 O 1–343（343 aa）	突变：N255K (N278K)	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 13 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 CDL CARDIOLIPIN × 4 LMT DODECYL-BETA-D-MALTOSIDE × 3 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 3.10 Å
7QSK Bovine complex I in lipid nanodisc, Active-Q10 提交 2022-01-13	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 O 1–343（343 aa）	突变：N255K (N278K)	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 19 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.84 Å
7QSL Bovine complex I in lipid nanodisc, Active-apo 提交 2022-01-13	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 O 1–343（343 aa）	突变：N255K (N278K)	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 20 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 8 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.76 Å
7QSM Bovine complex I in lipid nanodisc, Deactive-ligand (composite) 提交 2022-01-13	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 O 1–343（343 aa）	突变：N255K (N278K)	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 GOL GLYCEROL × 1 LMT DODECYL-BETA-D-MALTOSIDE × 1 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.30 Å
7QSN Bovine complex I in lipid nanodisc, Deactive-apo 提交 2022-01-13	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 O 1–343（343 aa）	突变：N255K (N278K)	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 6 CHD CHOLIC ACID × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.81 Å
7QSO Bovine complex I in lipid nanodisc, State 3 (Slack) 提交 2022-01-13	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 O 1–343（343 aa）	突变：N255K (N278K)	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 6 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CHD CHOLIC ACID × 2 CDL CARDIOLIPIN × 6 U10 UBIQUINONE-10 × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 3.02 Å
7R41 Bovine complex I in the presence of IM1761092, active class i (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 O 1–343（343 aa）	突变：N278K	LMT DODECYL-BETA-D-MALTOSIDE × 16 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R42 Bovine complex I in the presence of IM1761092, active class ii (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 O 1–343（343 aa）	突变：N278K	LMT DODECYL-BETA-D-MALTOSIDE × 17 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R43 Bovine complex I in the presence of IM1761092, active class iii (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 O 1–343（343 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 CDL CARDIOLIPIN × 5 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R44 Bovine complex I in the presence of IM1761092, active class iv (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 O 1–343（343 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 11 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R45 Bovine complex I in the presence of IM1761092, deactive class i (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 O 1–343（343 aa）	突变：N278K	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R46 Bovine complex I in the presence of IM1761092, deactive class ii (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 O 1–343（343 aa）	突变：N278K	LMT DODECYL-BETA-D-MALTOSIDE × 11 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R47 Bovine complex I in the presence of IM1761092, deactive class iii (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 O 1–343（343 aa）	突变：N278K	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R48 Bovine complex I in the presence of IM1761092, deactive class iv (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 O 1–343（343 aa）	突变：N278K	LMT DODECYL-BETA-D-MALTOSIDE × 15 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 13 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4C Bovine complex I in the presence of IM1761092, deactive class v (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 O 1–343（343 aa）	突变：N278K	LMT DODECYL-BETA-D-MALTOSIDE × 12 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4D Bovine complex I in the presence of IM1761092, deactive class vi (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 O 1–343（343 aa）	突变：N278K	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4F Bovine complex I in the presence of IM1761092, slack class i (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 O 1–343（343 aa）	突变：N278K	LMT DODECYL-BETA-D-MALTOSIDE × 7 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 3 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 CDL CARDIOLIPIN × 6 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R4G Bovine complex I in the presence of IM1761092, slack class ii (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 O 1–343（343 aa）	突变：N278K	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 LMT DODECYL-BETA-D-MALTOSIDE × 10 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.50 Å
8Q0A Inward-facing, closed proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 O 1–343（343 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 16 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 8 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 MG MAGNESIUM ION × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0F Inward-facing, open2 proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 O 1–343（343 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 21 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0J Inward-facing, slack proteoliposome complex I at 3.8 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 O 1–343（343 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 4 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.80 Å
8Q0M Outward-facing, closed proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 O 1–343（343 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0O Outward-facing, open2 proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 O 1–343（343 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0Q Outward-facing, slack proteoliposome complex I at 3.6 A. Initially purified in DDM 提交 2023-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 O 1–343（343 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 4 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.60 Å
8Q1P Inward-facing, open2 proteoliposome complex I at 2.9 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 O 1–343（343 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.90 Å
8Q1U Inward-facing, open1 proteoliposome complex I at 3.3 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 O 1–343（343 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 15 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 5 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.30 Å
8Q1Y Outward-facing, open2 proteoliposome complex I at 2.6 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 O 1–343（343 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 ZN ZINC ION × 2 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q25 Outward-facing, open1 proteoliposome complex I at 2.8 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 O 1–343（343 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 ZN ZINC ION × 2 MG MAGNESIUM ION × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.80 Å
8Q45 Inward-facing, closed proteoliposome complex I at 2.7 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 O 1–343（343 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 16 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.70 Å
8Q46 Inward-facing, open2 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 O 1–343（343 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q47 Inward-facing, open1 proteoliposome complex I at 2.9 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 O 1–343（343 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 15 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 26 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 5 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.90 Å
8Q48 Outward-facing, closed proteoliposome complex I at 2.5 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 O 1–343（343 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 35 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.50 Å
8Q49 Outward-facing, open2 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 O 1–343（343 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CHD CHOLIC ACID × 1 ZN ZINC ION × 2 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 FVH [[(2~{R},3~{S},4~{R},5~{R})-5-[(3~{R})-3-aminocarbonylpiperidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{R},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3-oxidanyl-4-phosphonooxy-oxolan-2-yl]methyl hydrogen phosphate × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q4A Outward-facing, open1 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 O 1–343（343 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
9SMF Reduced bovine complex I in lipid nanodisc, NADH-active-Q10 提交 2025-09-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 O 1–343（343 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 20 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 8 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.51 Å
9SMG Reduced bovine complex I in lipid nanodisc, NADH-active-altQ10 提交 2025-09-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 O 1–343（343 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 18 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.42 Å
9SMH Reduced bovine complex I in lipid nanodisc, NADH-active-DDM 提交 2025-09-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 O 1–343（343 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 17 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 LMT DODECYL-BETA-D-MALTOSIDE × 1 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.61 Å
9SMI Reduced bovine complex I in lipid nanodisc, NADH-deactive 提交 2025-09-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 O 1–343（343 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 27 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 LMT DODECYL-BETA-D-MALTOSIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 5 CHD CHOLIC ACID × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.01 Å
9W2U Cryo-EM structure of complex I on the bovine heart submitochondrial particles, open 提交 2025-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 O 24–343（320 aa）	未记录	FME N-FORMYLMETHIONINE × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 18 CDL CARDIOLIPIN × 6 CHD CHOLIC ACID × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.60 Å
9W2V Cryo-EM structure of complex I on the bovine heart submitochondrial particles, closed 提交 2025-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 O 24–343（320 aa）	未记录	FME N-FORMYLMETHIONINE × 4 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 19 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 12 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 6 MG MAGNESIUM ION × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.80 Å

共 49 个其他 PDB 条目、49 个 assembly。 打开独立比较页并筛选聚集状态

查看构建体与数据证据

UniProt名称	NDUAA_BOVIN
Isoform	—
PDB实体	15
链与序列区间	作者链 O； PDB构建体 87–314； UniProt 114–341

;NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial ;

物种未注明

UniProt P23934

当前结构中的状态

Assembly	聚集状态	构建体	突变与修饰	配体、离子与共同组分	实验方法与环境	结构质量
1	蛋白异源复合物 异源复合物 蛋白 × 45 PDB 声明：45-meric（45） 与蛋白拷贝数一致	链 R； UniProt 87–121	未记录	NADH-ubiquinone oxidoreductase chain 3 × 1 （P03898） NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial × 1 （P42026） NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial × 1 （P23709） NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial × 1 （P17694） NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial × 1 （P04394） NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial × 1 （P25708） ;NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, NDUFS1 ; × 1 （P15690） NADH-ubiquinone oxidoreductase chain 1 × 1 （P03887） NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial × 1 （P42028） NADH-ubiquinone oxidoreductase chain 6 × 1 （P03924） NADH-ubiquinone oxidoreductase chain 4L × 1 （P03902） NADH-ubiquinone oxidoreductase chain 5 × 1 （P03920） NADH-ubiquinone oxidoreductase chain 4 × 1 （P03910） NADH-ubiquinone oxidoreductase chain 2 × 1 （P03892） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, NDUFA10,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial ; × 1 （P34942） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial × 1 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial × 1 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 × 1 （Q02370） Acyl carrier protein, mitochondrial × 1 （P52505） Acyl carrier protein, mitochondrial × 1 （P52505） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 × 1 （P23935） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 × 1 （Q02366） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 ; × 1 （P42029） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 × 1 （Q8HXG6） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 ; × 1 （Q95KV7） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 × 1 （Q02377） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 ; × 1 （Q02371） NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial × 1 （Q02376） ;NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2 ; × 1 （Q02827） NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 × 1 （Q02379） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 × 1 （Q02378） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial × 1 （Q8HXG5） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial ; × 1 （Q02380） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 ; × 1 （Q02367） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, NDUFB2 × 1 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3, NDUFB3 × 1 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, NDUFB8 × 1 ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 ; × 1 （P48305） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 ; × 1 （Q02369） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 × 1 （Q02368） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10, NDUFB10,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10, NDUFB10 ; × 1 （Q02373） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 × 1 （O97725） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7, NDUFA7 × 1 NADH dehydrogenase [ubiquinone] flavoprotein 3, NDUFV3 × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液：pH 8 cryo-EM玻璃化条件：冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 4.35 Å

数据库中的同蛋白其他状态

以下每一行都是同一 UniProt 蛋白在另一个 PDB 条目中的 biological assembly， “相对当前条目”直接指出证据层面的不同；没有差异标签表示当前已读取字段一致。

其他 PDB	相对当前条目 5LC5	Assembly / 聚集状态	构建体	突变与修饰	配体、离子与非聚合物	实验方法与环境	结构质量
5LDW Structure of mammalian respiratory Complex I, class1 提交 2016-06-28	实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 R 87–121（35 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8；20 mM TRIS-HCL, 150 mM NaCl, 0.03% CYMAL-7 cryo-EM玻璃化条件 冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus present in a cold room, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 4.27 Å
5LDX Structure of mammalian respiratory Complex I, class3. 提交 2016-06-28	结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 R 87–121（35 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 20 mM TRIS-HCL, 150 mM NaCl, 0.03% CYMAL-7；pH 8 cryo-EM玻璃化条件 冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 5.60 Å
5O31 Mitochondrial complex I in the deactive state 提交 2017-05-23	构建体不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 R 29–124（96 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.55 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.13 Å
7DGQ Activity optimized supercomplex state1 提交 2020-11-12	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 I 29–124（96 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 CU COPPER (II) ION × 3 HEA HEME-A × 2 MG MAGNESIUM ION × 1 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 UQ2 UBIQUINONE-2 × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 5.00 Å
7DGR Activity optimized supercomplex state2 提交 2020-11-12	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 I 29–124（96 aa）	未记录	FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 3 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.60 Å
7DGS Activity optimized supercomplex state3 提交 2020-11-12	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 I 29–124（96 aa）	未记录	FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 7.80 Å
7DGZ Activity optimized complex I (closed form) 提交 2020-11-12	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 I 29–124（96 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 2 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 3.80 Å
7DH0 Activity optimized complex I (open form) 提交 2020-11-12	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 I 29–124（96 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.20 Å
7DKF Activity optimized supercomplex state4 提交 2020-11-24	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 I2 29–124（96 aa）	未记录	HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 8.30 Å
7QSD Bovine complex I in the active state at 3.1 A 提交 2022-01-13	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 R 1–124（124 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 13 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 CDL CARDIOLIPIN × 4 LMT DODECYL-BETA-D-MALTOSIDE × 3 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 3.10 Å
7QSK Bovine complex I in lipid nanodisc, Active-Q10 提交 2022-01-13	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 R 1–124（124 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 19 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.84 Å
7QSL Bovine complex I in lipid nanodisc, Active-apo 提交 2022-01-13	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 R 1–124（124 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 20 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 8 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.76 Å
7QSM Bovine complex I in lipid nanodisc, Deactive-ligand (composite) 提交 2022-01-13	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 R 1–124（124 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 GOL GLYCEROL × 1 LMT DODECYL-BETA-D-MALTOSIDE × 1 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.30 Å
7QSN Bovine complex I in lipid nanodisc, Deactive-apo 提交 2022-01-13	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 R 1–124（124 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 6 CHD CHOLIC ACID × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.81 Å
7QSO Bovine complex I in lipid nanodisc, State 3 (Slack) 提交 2022-01-13	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 R 1–124（124 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 6 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CHD CHOLIC ACID × 2 CDL CARDIOLIPIN × 6 U10 UBIQUINONE-10 × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 3.02 Å
7R41 Bovine complex I in the presence of IM1761092, active class i (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 R 1–124（124 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 16 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R42 Bovine complex I in the presence of IM1761092, active class ii (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 R 1–124（124 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 17 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R43 Bovine complex I in the presence of IM1761092, active class iii (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 R 1–124（124 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 CDL CARDIOLIPIN × 5 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R44 Bovine complex I in the presence of IM1761092, active class iv (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 R 1–124（124 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 11 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R45 Bovine complex I in the presence of IM1761092, deactive class i (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 R 1–124（124 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R46 Bovine complex I in the presence of IM1761092, deactive class ii (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 R 1–124（124 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 11 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R47 Bovine complex I in the presence of IM1761092, deactive class iii (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 R 1–124（124 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R48 Bovine complex I in the presence of IM1761092, deactive class iv (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 R 1–124（124 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 15 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 13 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4C Bovine complex I in the presence of IM1761092, deactive class v (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 R 1–124（124 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 12 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4D Bovine complex I in the presence of IM1761092, deactive class vi (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 R 1–124（124 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4F Bovine complex I in the presence of IM1761092, slack class i (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 R 1–124（124 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 7 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 3 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 CDL CARDIOLIPIN × 6 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R4G Bovine complex I in the presence of IM1761092, slack class ii (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 R 1–124（124 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 LMT DODECYL-BETA-D-MALTOSIDE × 10 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.50 Å
8Q0A Inward-facing, closed proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 R 1–124（124 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 16 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 8 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 MG MAGNESIUM ION × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0F Inward-facing, open2 proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 R 1–124（124 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 21 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0J Inward-facing, slack proteoliposome complex I at 3.8 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 R 1–124（124 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 4 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.80 Å
8Q0M Outward-facing, closed proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 R 1–124（124 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0O Outward-facing, open2 proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 R 1–124（124 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0Q Outward-facing, slack proteoliposome complex I at 3.6 A. Initially purified in DDM 提交 2023-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 R 1–124（124 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 4 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.60 Å
8Q1P Inward-facing, open2 proteoliposome complex I at 2.9 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 R 1–124（124 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.90 Å
8Q1U Inward-facing, open1 proteoliposome complex I at 3.3 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 R 1–124（124 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 15 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 5 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.30 Å
8Q1Y Outward-facing, open2 proteoliposome complex I at 2.6 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 R 1–124（124 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 ZN ZINC ION × 2 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q25 Outward-facing, open1 proteoliposome complex I at 2.8 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 R 1–124（124 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 ZN ZINC ION × 2 MG MAGNESIUM ION × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.80 Å
8Q45 Inward-facing, closed proteoliposome complex I at 2.7 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 R 1–124（124 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 16 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.70 Å
8Q46 Inward-facing, open2 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 R 1–124（124 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q47 Inward-facing, open1 proteoliposome complex I at 2.9 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 R 1–124（124 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 15 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 26 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 5 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.90 Å
8Q48 Outward-facing, closed proteoliposome complex I at 2.5 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 R 1–124（124 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 35 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.50 Å
8Q49 Outward-facing, open2 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 R 1–124（124 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CHD CHOLIC ACID × 1 ZN ZINC ION × 2 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 FVH [[(2~{R},3~{S},4~{R},5~{R})-5-[(3~{R})-3-aminocarbonylpiperidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{R},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3-oxidanyl-4-phosphonooxy-oxolan-2-yl]methyl hydrogen phosphate × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q4A Outward-facing, open1 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 R 1–124（124 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
9SMF Reduced bovine complex I in lipid nanodisc, NADH-active-Q10 提交 2025-09-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 R 1–124（124 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 20 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 8 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.51 Å
9SMG Reduced bovine complex I in lipid nanodisc, NADH-active-altQ10 提交 2025-09-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 R 1–124（124 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 18 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.42 Å
9SMH Reduced bovine complex I in lipid nanodisc, NADH-active-DDM 提交 2025-09-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 R 1–124（124 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 17 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 LMT DODECYL-BETA-D-MALTOSIDE × 1 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.61 Å
9SMI Reduced bovine complex I in lipid nanodisc, NADH-deactive 提交 2025-09-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 R 1–124（124 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 27 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 LMT DODECYL-BETA-D-MALTOSIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 5 CHD CHOLIC ACID × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.01 Å
9W2U Cryo-EM structure of complex I on the bovine heart submitochondrial particles, open 提交 2025-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 R 29–124（96 aa）	未记录	FME N-FORMYLMETHIONINE × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 18 CDL CARDIOLIPIN × 6 CHD CHOLIC ACID × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.60 Å
9W2V Cryo-EM structure of complex I on the bovine heart submitochondrial particles, closed 提交 2025-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 R 29–124（96 aa）	未记录	FME N-FORMYLMETHIONINE × 4 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 19 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 12 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 6 MG MAGNESIUM ION × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.80 Å

共 49 个其他 PDB 条目、49 个 assembly。 打开独立比较页并筛选聚集状态

查看构建体与数据证据

UniProt名称	NDUS6_BOVIN
Isoform	—
PDB实体	18
链与序列区间	作者链 R； PDB构建体 55–89； UniProt 87–121

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2

物种未注明

UniProt Q02370

当前结构中的状态

Assembly	聚集状态	构建体	突变与修饰	配体、离子与共同组分	实验方法与环境	结构质量
1	蛋白异源复合物 异源复合物 蛋白 × 45 PDB 声明：45-meric（45） 与蛋白拷贝数一致	链 S； UniProt 17–96	未记录	NADH-ubiquinone oxidoreductase chain 3 × 1 （P03898） NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial × 1 （P42026） NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial × 1 （P23709） NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial × 1 （P17694） NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial × 1 （P04394） NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial × 1 （P25708） ;NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, NDUFS1 ; × 1 （P15690） NADH-ubiquinone oxidoreductase chain 1 × 1 （P03887） NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial × 1 （P42028） NADH-ubiquinone oxidoreductase chain 6 × 1 （P03924） NADH-ubiquinone oxidoreductase chain 4L × 1 （P03902） NADH-ubiquinone oxidoreductase chain 5 × 1 （P03920） NADH-ubiquinone oxidoreductase chain 4 × 1 （P03910） NADH-ubiquinone oxidoreductase chain 2 × 1 （P03892） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, NDUFA10,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial ; × 1 （P34942） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial × 1 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial × 1 ;NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial ; × 1 （P23934） Acyl carrier protein, mitochondrial × 1 （P52505） Acyl carrier protein, mitochondrial × 1 （P52505） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 × 1 （P23935） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 × 1 （Q02366） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 ; × 1 （P42029） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 × 1 （Q8HXG6） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 ; × 1 （Q95KV7） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 × 1 （Q02377） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 ; × 1 （Q02371） NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial × 1 （Q02376） ;NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2 ; × 1 （Q02827） NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 × 1 （Q02379） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 × 1 （Q02378） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial × 1 （Q8HXG5） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial ; × 1 （Q02380） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 ; × 1 （Q02367） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, NDUFB2 × 1 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3, NDUFB3 × 1 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, NDUFB8 × 1 ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 ; × 1 （P48305） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 ; × 1 （Q02369） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 × 1 （Q02368） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10, NDUFB10,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10, NDUFB10 ; × 1 （Q02373） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 × 1 （O97725） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7, NDUFA7 × 1 NADH dehydrogenase [ubiquinone] flavoprotein 3, NDUFV3 × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液：pH 8 cryo-EM玻璃化条件：冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 4.35 Å

数据库中的同蛋白其他状态

以下每一行都是同一 UniProt 蛋白在另一个 PDB 条目中的 biological assembly， “相对当前条目”直接指出证据层面的不同；没有差异标签表示当前已读取字段一致。

其他 PDB	相对当前条目 5LC5	Assembly / 聚集状态	构建体	突变与修饰	配体、离子与非聚合物	实验方法与环境	结构质量
5LDW Structure of mammalian respiratory Complex I, class1 提交 2016-06-28	构建体不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 S 1–99（99 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8；20 mM TRIS-HCL, 150 mM NaCl, 0.03% CYMAL-7 cryo-EM玻璃化条件 冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus present in a cold room, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 4.27 Å
5LDX Structure of mammalian respiratory Complex I, class3. 提交 2016-06-28	构建体不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 S 1–99（99 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 20 mM TRIS-HCL, 150 mM NaCl, 0.03% CYMAL-7；pH 8 cryo-EM玻璃化条件 冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 5.60 Å
5O31 Mitochondrial complex I in the deactive state 提交 2017-05-23	构建体不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 S 2–99（98 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.55 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.13 Å
7DGQ Activity optimized supercomplex state1 提交 2020-11-12	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 K 2–99（98 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 CU COPPER (II) ION × 3 HEA HEME-A × 2 MG MAGNESIUM ION × 1 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 UQ2 UBIQUINONE-2 × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 5.00 Å
7DGR Activity optimized supercomplex state2 提交 2020-11-12	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 K 2–99（98 aa）	未记录	FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 3 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.60 Å
7DGS Activity optimized supercomplex state3 提交 2020-11-12	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 K 2–99（98 aa）	未记录	FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 7.80 Å
7DGZ Activity optimized complex I (closed form) 提交 2020-11-12	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 K 2–99（98 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 2 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 3.80 Å
7DH0 Activity optimized complex I (open form) 提交 2020-11-12	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 K 2–99（98 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.20 Å
7DKF Activity optimized supercomplex state4 提交 2020-11-24	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 K2 2–99（98 aa）	未记录	HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 8.30 Å
7QSD Bovine complex I in the active state at 3.1 A 提交 2022-01-13	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 S 1–99（99 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 13 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 CDL CARDIOLIPIN × 4 LMT DODECYL-BETA-D-MALTOSIDE × 3 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 3.10 Å
7QSK Bovine complex I in lipid nanodisc, Active-Q10 提交 2022-01-13	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 S 1–99（99 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 19 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.84 Å
7QSL Bovine complex I in lipid nanodisc, Active-apo 提交 2022-01-13	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 S 1–99（99 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 20 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 8 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.76 Å
7QSM Bovine complex I in lipid nanodisc, Deactive-ligand (composite) 提交 2022-01-13	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 S 1–99（99 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 GOL GLYCEROL × 1 LMT DODECYL-BETA-D-MALTOSIDE × 1 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.30 Å
7QSN Bovine complex I in lipid nanodisc, Deactive-apo 提交 2022-01-13	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 S 1–99（99 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 6 CHD CHOLIC ACID × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.81 Å
7QSO Bovine complex I in lipid nanodisc, State 3 (Slack) 提交 2022-01-13	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 S 1–99（99 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 6 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CHD CHOLIC ACID × 2 CDL CARDIOLIPIN × 6 U10 UBIQUINONE-10 × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 3.02 Å
7R41 Bovine complex I in the presence of IM1761092, active class i (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 S 1–99（99 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 16 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R42 Bovine complex I in the presence of IM1761092, active class ii (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 S 1–99（99 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 17 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R43 Bovine complex I in the presence of IM1761092, active class iii (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 S 1–99（99 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 CDL CARDIOLIPIN × 5 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R44 Bovine complex I in the presence of IM1761092, active class iv (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 S 1–99（99 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 11 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R45 Bovine complex I in the presence of IM1761092, deactive class i (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 S 1–99（99 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R46 Bovine complex I in the presence of IM1761092, deactive class ii (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 S 1–99（99 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 11 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R47 Bovine complex I in the presence of IM1761092, deactive class iii (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 S 1–99（99 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R48 Bovine complex I in the presence of IM1761092, deactive class iv (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 S 1–99（99 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 15 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 13 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4C Bovine complex I in the presence of IM1761092, deactive class v (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 S 1–99（99 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 12 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4D Bovine complex I in the presence of IM1761092, deactive class vi (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 S 1–99（99 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4F Bovine complex I in the presence of IM1761092, slack class i (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 S 1–99（99 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 7 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 3 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 CDL CARDIOLIPIN × 6 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R4G Bovine complex I in the presence of IM1761092, slack class ii (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 S 1–99（99 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 LMT DODECYL-BETA-D-MALTOSIDE × 10 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.50 Å
8Q0A Inward-facing, closed proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 S 1–99（99 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 16 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 8 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 MG MAGNESIUM ION × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0F Inward-facing, open2 proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 S 1–99（99 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 21 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0J Inward-facing, slack proteoliposome complex I at 3.8 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 S 1–99（99 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 4 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.80 Å
8Q0M Outward-facing, closed proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 S 1–99（99 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0O Outward-facing, open2 proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 S 1–99（99 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0Q Outward-facing, slack proteoliposome complex I at 3.6 A. Initially purified in DDM 提交 2023-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 S 1–99（99 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 4 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.60 Å
8Q1P Inward-facing, open2 proteoliposome complex I at 2.9 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 S 1–99（99 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.90 Å
8Q1U Inward-facing, open1 proteoliposome complex I at 3.3 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 S 1–99（99 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 15 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 5 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.30 Å
8Q1Y Outward-facing, open2 proteoliposome complex I at 2.6 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 S 1–99（99 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 ZN ZINC ION × 2 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q25 Outward-facing, open1 proteoliposome complex I at 2.8 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 S 1–99（99 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 ZN ZINC ION × 2 MG MAGNESIUM ION × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.80 Å
8Q45 Inward-facing, closed proteoliposome complex I at 2.7 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 S 1–99（99 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 16 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.70 Å
8Q46 Inward-facing, open2 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 S 1–99（99 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q47 Inward-facing, open1 proteoliposome complex I at 2.9 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 S 1–99（99 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 15 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 26 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 5 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.90 Å
8Q48 Outward-facing, closed proteoliposome complex I at 2.5 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 S 1–99（99 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 35 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.50 Å
8Q49 Outward-facing, open2 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 S 1–99（99 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CHD CHOLIC ACID × 1 ZN ZINC ION × 2 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 FVH [[(2~{R},3~{S},4~{R},5~{R})-5-[(3~{R})-3-aminocarbonylpiperidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{R},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3-oxidanyl-4-phosphonooxy-oxolan-2-yl]methyl hydrogen phosphate × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q4A Outward-facing, open1 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 S 1–99（99 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
9SMF Reduced bovine complex I in lipid nanodisc, NADH-active-Q10 提交 2025-09-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 S 1–99（99 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 20 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 8 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.51 Å
9SMG Reduced bovine complex I in lipid nanodisc, NADH-active-altQ10 提交 2025-09-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 S 1–99（99 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 18 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.42 Å
9SMH Reduced bovine complex I in lipid nanodisc, NADH-active-DDM 提交 2025-09-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 S 1–99（99 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 17 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 LMT DODECYL-BETA-D-MALTOSIDE × 1 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.61 Å
9SMI Reduced bovine complex I in lipid nanodisc, NADH-deactive 提交 2025-09-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 S 1–99（99 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 27 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 LMT DODECYL-BETA-D-MALTOSIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 5 CHD CHOLIC ACID × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.01 Å
9W2U Cryo-EM structure of complex I on the bovine heart submitochondrial particles, open 提交 2025-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 S 13–99（87 aa）	未记录	FME N-FORMYLMETHIONINE × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 18 CDL CARDIOLIPIN × 6 CHD CHOLIC ACID × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.60 Å
9W2V Cryo-EM structure of complex I on the bovine heart submitochondrial particles, closed 提交 2025-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 S 13–99（87 aa）	未记录	FME N-FORMYLMETHIONINE × 4 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 19 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 12 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 6 MG MAGNESIUM ION × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.80 Å

共 49 个其他 PDB 条目、49 个 assembly。 打开独立比较页并筛选聚集状态

查看构建体与数据证据

UniProt名称	NDUA2_BOVIN
Isoform	—
PDB实体	19
链与序列区间	作者链 S； PDB构建体 1–80； UniProt 17–96

Acyl carrier protein, mitochondrial

物种未注明

UniProt P52505

当前结构中的状态

Assembly	聚集状态	构建体	突变与修饰	配体、离子与共同组分	实验方法与环境	结构质量
1	蛋白异源复合物 异源复合物 蛋白 × 45 PDB 声明：45-meric（45） 与蛋白拷贝数一致	链 T； UniProt 76–150 链 U； UniProt 72–156	未记录	NADH-ubiquinone oxidoreductase chain 3 × 1 （P03898） NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial × 1 （P42026） NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial × 1 （P23709） NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial × 1 （P17694） NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial × 1 （P04394） NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial × 1 （P25708） ;NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, NDUFS1 ; × 1 （P15690） NADH-ubiquinone oxidoreductase chain 1 × 1 （P03887） NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial × 1 （P42028） NADH-ubiquinone oxidoreductase chain 6 × 1 （P03924） NADH-ubiquinone oxidoreductase chain 4L × 1 （P03902） NADH-ubiquinone oxidoreductase chain 5 × 1 （P03920） NADH-ubiquinone oxidoreductase chain 4 × 1 （P03910） NADH-ubiquinone oxidoreductase chain 2 × 1 （P03892） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, NDUFA10,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial ; × 1 （P34942） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial × 1 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial × 1 ;NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial ; × 1 （P23934） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 × 1 （Q02370） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 × 1 （P23935） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 × 1 （Q02366） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 ; × 1 （P42029） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 × 1 （Q8HXG6） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 ; × 1 （Q95KV7） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 × 1 （Q02377） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 ; × 1 （Q02371） NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial × 1 （Q02376） ;NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2 ; × 1 （Q02827） NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 × 1 （Q02379） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 × 1 （Q02378） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial × 1 （Q8HXG5） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial ; × 1 （Q02380） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 ; × 1 （Q02367） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, NDUFB2 × 1 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3, NDUFB3 × 1 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, NDUFB8 × 1 ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 ; × 1 （P48305） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 ; × 1 （Q02369） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 × 1 （Q02368） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10, NDUFB10,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10, NDUFB10 ; × 1 （Q02373） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 × 1 （O97725） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7, NDUFA7 × 1 NADH dehydrogenase [ubiquinone] flavoprotein 3, NDUFV3 × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液：pH 8 cryo-EM玻璃化条件：冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 4.35 Å

数据库中的同蛋白其他状态

以下每一行都是同一 UniProt 蛋白在另一个 PDB 条目中的 biological assembly， “相对当前条目”直接指出证据层面的不同；没有差异标签表示当前已读取字段一致。

其他 PDB	相对当前条目 5LC5	Assembly / 聚集状态	构建体	突变与修饰	配体、离子与非聚合物	实验方法与环境	结构质量
5LDW Structure of mammalian respiratory Complex I, class1 提交 2016-06-28	构建体不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 T 69–156（88 aa） 链 U 69–156（88 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8；20 mM TRIS-HCL, 150 mM NaCl, 0.03% CYMAL-7 cryo-EM玻璃化条件 冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus present in a cold room, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 4.27 Å
5LDX Structure of mammalian respiratory Complex I, class3. 提交 2016-06-28	构建体不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 T 69–156（88 aa） 链 U 69–156（88 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 20 mM TRIS-HCL, 150 mM NaCl, 0.03% CYMAL-7；pH 8 cryo-EM玻璃化条件 冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 5.60 Å
5O31 Mitochondrial complex I in the deactive state 提交 2017-05-23	构建体不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 T 69–156（88 aa） 链 U 69–156（88 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.55 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.13 Å
7DGQ Activity optimized supercomplex state1 提交 2020-11-12	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 M 71–156（86 aa） 链 W 71–156（86 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 CU COPPER (II) ION × 3 HEA HEME-A × 2 MG MAGNESIUM ION × 1 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 UQ2 UBIQUINONE-2 × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 5.00 Å
7DGR Activity optimized supercomplex state2 提交 2020-11-12	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 M 69–156（88 aa） 链 W 69–156（88 aa）	未记录	FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 3 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.60 Å
7DGS Activity optimized supercomplex state3 提交 2020-11-12	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 M 69–156（88 aa） 链 W 69–156（88 aa）	未记录	FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 7.80 Å
7DGZ Activity optimized complex I (closed form) 提交 2020-11-12	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 M 69–156（88 aa） 链 W 69–156（88 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 2 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 3.80 Å
7DH0 Activity optimized complex I (open form) 提交 2020-11-12	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 M 69–156（88 aa） 链 W 69–156（88 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.20 Å
7DKF Activity optimized supercomplex state4 提交 2020-11-24	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 M2 69–156（88 aa） 链 W2 69–156（88 aa）	未记录	HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 8.30 Å
7QSD Bovine complex I in the active state at 3.1 A 提交 2022-01-13	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 T 1–156（156 aa） 链 U 1–156（156 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 13 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 CDL CARDIOLIPIN × 4 LMT DODECYL-BETA-D-MALTOSIDE × 3 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 3.10 Å
7QSK Bovine complex I in lipid nanodisc, Active-Q10 提交 2022-01-13	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 T 1–156（156 aa） 链 U 1–156（156 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 19 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.84 Å
7QSL Bovine complex I in lipid nanodisc, Active-apo 提交 2022-01-13	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 T 1–156（156 aa） 链 U 1–156（156 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 20 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 8 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.76 Å
7QSM Bovine complex I in lipid nanodisc, Deactive-ligand (composite) 提交 2022-01-13	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 T 1–156（156 aa） 链 U 1–156（156 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 GOL GLYCEROL × 1 LMT DODECYL-BETA-D-MALTOSIDE × 1 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.30 Å
7QSN Bovine complex I in lipid nanodisc, Deactive-apo 提交 2022-01-13	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 T 1–156（156 aa） 链 U 1–156（156 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 6 CHD CHOLIC ACID × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.81 Å
7QSO Bovine complex I in lipid nanodisc, State 3 (Slack) 提交 2022-01-13	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 T 1–156（156 aa） 链 U 1–156（156 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 6 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CHD CHOLIC ACID × 2 CDL CARDIOLIPIN × 6 U10 UBIQUINONE-10 × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 3.02 Å
7R41 Bovine complex I in the presence of IM1761092, active class i (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 T 1–156（156 aa） 链 U 1–156（156 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 16 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R42 Bovine complex I in the presence of IM1761092, active class ii (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 T 1–156（156 aa） 链 U 1–156（156 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 17 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R43 Bovine complex I in the presence of IM1761092, active class iii (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 T 1–156（156 aa） 链 U 1–156（156 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 CDL CARDIOLIPIN × 5 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R44 Bovine complex I in the presence of IM1761092, active class iv (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 T 1–156（156 aa） 链 U 1–156（156 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 11 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R45 Bovine complex I in the presence of IM1761092, deactive class i (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 T 1–156（156 aa） 链 U 1–156（156 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R46 Bovine complex I in the presence of IM1761092, deactive class ii (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 T 1–156（156 aa） 链 U 1–156（156 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 11 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R47 Bovine complex I in the presence of IM1761092, deactive class iii (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 T 1–156（156 aa） 链 U 1–156（156 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R48 Bovine complex I in the presence of IM1761092, deactive class iv (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 T 1–156（156 aa） 链 U 1–156（156 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 15 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 13 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4C Bovine complex I in the presence of IM1761092, deactive class v (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 T 1–156（156 aa） 链 U 1–156（156 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 12 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4D Bovine complex I in the presence of IM1761092, deactive class vi (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 T 1–156（156 aa） 链 U 1–156（156 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4F Bovine complex I in the presence of IM1761092, slack class i (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 T 1–156（156 aa） 链 U 1–156（156 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 7 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 3 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 CDL CARDIOLIPIN × 6 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R4G Bovine complex I in the presence of IM1761092, slack class ii (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 T 1–156（156 aa） 链 U 1–156（156 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 LMT DODECYL-BETA-D-MALTOSIDE × 10 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.50 Å
8Q0A Inward-facing, closed proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 T 1–156（156 aa） 链 U 1–156（156 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 16 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 8 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 MG MAGNESIUM ION × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0F Inward-facing, open2 proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 T 1–156（156 aa） 链 U 1–156（156 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 21 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0J Inward-facing, slack proteoliposome complex I at 3.8 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 T 1–156（156 aa） 链 U 1–156（156 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 4 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.80 Å
8Q0M Outward-facing, closed proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 T 1–156（156 aa） 链 U 1–156（156 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0O Outward-facing, open2 proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 T 1–156（156 aa） 链 U 1–156（156 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0Q Outward-facing, slack proteoliposome complex I at 3.6 A. Initially purified in DDM 提交 2023-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 T 1–156（156 aa） 链 U 1–156（156 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 4 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.60 Å
8Q1P Inward-facing, open2 proteoliposome complex I at 2.9 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 T 1–156（156 aa） 链 U 1–156（156 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.90 Å
8Q1U Inward-facing, open1 proteoliposome complex I at 3.3 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 T 1–156（156 aa） 链 U 1–156（156 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 15 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 5 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.30 Å
8Q1Y Outward-facing, open2 proteoliposome complex I at 2.6 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 T 1–156（156 aa） 链 U 1–156（156 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 ZN ZINC ION × 2 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q25 Outward-facing, open1 proteoliposome complex I at 2.8 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 T 1–156（156 aa） 链 U 1–156（156 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 ZN ZINC ION × 2 MG MAGNESIUM ION × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.80 Å
8Q45 Inward-facing, closed proteoliposome complex I at 2.7 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 T 1–156（156 aa） 链 U 1–156（156 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 16 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.70 Å
8Q46 Inward-facing, open2 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 T 1–156（156 aa） 链 U 1–156（156 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q47 Inward-facing, open1 proteoliposome complex I at 2.9 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 T 1–156（156 aa） 链 U 1–156（156 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 15 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 26 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 5 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.90 Å
8Q48 Outward-facing, closed proteoliposome complex I at 2.5 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 T 1–156（156 aa） 链 U 1–156（156 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 35 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.50 Å
8Q49 Outward-facing, open2 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 T 1–156（156 aa） 链 U 1–156（156 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CHD CHOLIC ACID × 1 ZN ZINC ION × 2 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 FVH [[(2~{R},3~{S},4~{R},5~{R})-5-[(3~{R})-3-aminocarbonylpiperidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{R},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3-oxidanyl-4-phosphonooxy-oxolan-2-yl]methyl hydrogen phosphate × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q4A Outward-facing, open1 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 T 1–156（156 aa） 链 U 1–156（156 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
9SMF Reduced bovine complex I in lipid nanodisc, NADH-active-Q10 提交 2025-09-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 T 1–156（156 aa） 链 U 1–156（156 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 20 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 8 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.51 Å
9SMG Reduced bovine complex I in lipid nanodisc, NADH-active-altQ10 提交 2025-09-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 T 1–156（156 aa） 链 U 1–156（156 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 18 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.42 Å
9SMH Reduced bovine complex I in lipid nanodisc, NADH-active-DDM 提交 2025-09-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 T 1–156（156 aa） 链 U 1–156（156 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 17 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 LMT DODECYL-BETA-D-MALTOSIDE × 1 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.61 Å
9SMI Reduced bovine complex I in lipid nanodisc, NADH-deactive 提交 2025-09-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 T 1–156（156 aa） 链 U 1–156（156 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 27 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 LMT DODECYL-BETA-D-MALTOSIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 5 CHD CHOLIC ACID × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.01 Å
9W2U Cryo-EM structure of complex I on the bovine heart submitochondrial particles, open 提交 2025-07-28	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 U 71–156（86 aa）	未记录	FME N-FORMYLMETHIONINE × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 18 CDL CARDIOLIPIN × 6 CHD CHOLIC ACID × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.60 Å
9W2V Cryo-EM structure of complex I on the bovine heart submitochondrial particles, closed 提交 2025-07-28	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 U 71–156（86 aa）	未记录	FME N-FORMYLMETHIONINE × 4 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 19 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 12 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 6 MG MAGNESIUM ION × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.80 Å

共 49 个其他 PDB 条目、49 个 assembly。 打开独立比较页并筛选聚集状态

查看构建体与数据证据

UniProt名称	ACPM_BOVIN
Isoform	—
PDB实体	20, 21
链与序列区间	作者链 T； PDB构建体 1–75； UniProt 76–150 作者链 U； PDB构建体 1–85； UniProt 72–156

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5

物种未注明

UniProt P23935

当前结构中的状态

Assembly	聚集状态	构建体	突变与修饰	配体、离子与共同组分	实验方法与环境	结构质量
1	蛋白异源复合物 异源复合物 蛋白 × 45 PDB 声明：45-meric（45） 与蛋白拷贝数一致	链 V； UniProt 1–116	未记录	NADH-ubiquinone oxidoreductase chain 3 × 1 （P03898） NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial × 1 （P42026） NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial × 1 （P23709） NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial × 1 （P17694） NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial × 1 （P04394） NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial × 1 （P25708） ;NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, NDUFS1 ; × 1 （P15690） NADH-ubiquinone oxidoreductase chain 1 × 1 （P03887） NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial × 1 （P42028） NADH-ubiquinone oxidoreductase chain 6 × 1 （P03924） NADH-ubiquinone oxidoreductase chain 4L × 1 （P03902） NADH-ubiquinone oxidoreductase chain 5 × 1 （P03920） NADH-ubiquinone oxidoreductase chain 4 × 1 （P03910） NADH-ubiquinone oxidoreductase chain 2 × 1 （P03892） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, NDUFA10,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial ; × 1 （P34942） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial × 1 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial × 1 ;NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial ; × 1 （P23934） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 × 1 （Q02370） Acyl carrier protein, mitochondrial × 1 （P52505） Acyl carrier protein, mitochondrial × 1 （P52505） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 × 1 （Q02366） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 ; × 1 （P42029） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 × 1 （Q8HXG6） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 ; × 1 （Q95KV7） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 × 1 （Q02377） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 ; × 1 （Q02371） NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial × 1 （Q02376） ;NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2 ; × 1 （Q02827） NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 × 1 （Q02379） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 × 1 （Q02378） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial × 1 （Q8HXG5） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial ; × 1 （Q02380） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 ; × 1 （Q02367） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, NDUFB2 × 1 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3, NDUFB3 × 1 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, NDUFB8 × 1 ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 ; × 1 （P48305） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 ; × 1 （Q02369） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 × 1 （Q02368） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10, NDUFB10,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10, NDUFB10 ; × 1 （Q02373） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 × 1 （O97725） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7, NDUFA7 × 1 NADH dehydrogenase [ubiquinone] flavoprotein 3, NDUFV3 × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液：pH 8 cryo-EM玻璃化条件：冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 4.35 Å

数据库中的同蛋白其他状态

以下每一行都是同一 UniProt 蛋白在另一个 PDB 条目中的 biological assembly， “相对当前条目”直接指出证据层面的不同；没有差异标签表示当前已读取字段一致。

其他 PDB	相对当前条目 5LC5	Assembly / 聚集状态	构建体	突变与修饰	配体、离子与非聚合物	实验方法与环境	结构质量
5LDW Structure of mammalian respiratory Complex I, class1 提交 2016-06-28	构建体不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 V 2–116（115 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8；20 mM TRIS-HCL, 150 mM NaCl, 0.03% CYMAL-7 cryo-EM玻璃化条件 冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus present in a cold room, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 4.27 Å
5LDX Structure of mammalian respiratory Complex I, class3. 提交 2016-06-28	构建体不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 V 2–116（115 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 20 mM TRIS-HCL, 150 mM NaCl, 0.03% CYMAL-7；pH 8 cryo-EM玻璃化条件 冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 5.60 Å
5O31 Mitochondrial complex I in the deactive state 提交 2017-05-23	构建体不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 V 2–116（115 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.55 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.13 Å
7DGQ Activity optimized supercomplex state1 提交 2020-11-12	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 N 2–116（115 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 CU COPPER (II) ION × 3 HEA HEME-A × 2 MG MAGNESIUM ION × 1 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 UQ2 UBIQUINONE-2 × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 5.00 Å
7DGR Activity optimized supercomplex state2 提交 2020-11-12	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 N 2–116（115 aa）	未记录	FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 3 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.60 Å
7DGS Activity optimized supercomplex state3 提交 2020-11-12	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 N 2–116（115 aa）	未记录	FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 7.80 Å
7DGZ Activity optimized complex I (closed form) 提交 2020-11-12	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 N 2–116（115 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 2 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 3.80 Å
7DH0 Activity optimized complex I (open form) 提交 2020-11-12	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 N 2–116（115 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.20 Å
7DKF Activity optimized supercomplex state4 提交 2020-11-24	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 N2 2–116（115 aa）	未记录	HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 8.30 Å
7QSD Bovine complex I in the active state at 3.1 A 提交 2022-01-13	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 V 1–116（116 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 13 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 CDL CARDIOLIPIN × 4 LMT DODECYL-BETA-D-MALTOSIDE × 3 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 3.10 Å
7QSK Bovine complex I in lipid nanodisc, Active-Q10 提交 2022-01-13	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 V 1–116（116 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 19 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.84 Å
7QSL Bovine complex I in lipid nanodisc, Active-apo 提交 2022-01-13	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 V 1–116（116 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 20 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 8 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.76 Å
7QSM Bovine complex I in lipid nanodisc, Deactive-ligand (composite) 提交 2022-01-13	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 V 1–116（116 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 GOL GLYCEROL × 1 LMT DODECYL-BETA-D-MALTOSIDE × 1 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.30 Å
7QSN Bovine complex I in lipid nanodisc, Deactive-apo 提交 2022-01-13	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 V 1–116（116 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 6 CHD CHOLIC ACID × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.81 Å
7QSO Bovine complex I in lipid nanodisc, State 3 (Slack) 提交 2022-01-13	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 V 1–116（116 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 6 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CHD CHOLIC ACID × 2 CDL CARDIOLIPIN × 6 U10 UBIQUINONE-10 × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 3.02 Å
7R41 Bovine complex I in the presence of IM1761092, active class i (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 V 1–116（116 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 16 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R42 Bovine complex I in the presence of IM1761092, active class ii (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 V 1–116（116 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 17 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R43 Bovine complex I in the presence of IM1761092, active class iii (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 V 1–116（116 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 CDL CARDIOLIPIN × 5 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R44 Bovine complex I in the presence of IM1761092, active class iv (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 V 1–116（116 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 11 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R45 Bovine complex I in the presence of IM1761092, deactive class i (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 V 1–116（116 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R46 Bovine complex I in the presence of IM1761092, deactive class ii (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 V 1–116（116 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 11 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R47 Bovine complex I in the presence of IM1761092, deactive class iii (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 V 1–116（116 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R48 Bovine complex I in the presence of IM1761092, deactive class iv (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 V 1–116（116 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 15 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 13 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4C Bovine complex I in the presence of IM1761092, deactive class v (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 V 1–116（116 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 12 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4D Bovine complex I in the presence of IM1761092, deactive class vi (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 V 1–116（116 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4F Bovine complex I in the presence of IM1761092, slack class i (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 V 1–116（116 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 7 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 3 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 CDL CARDIOLIPIN × 6 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R4G Bovine complex I in the presence of IM1761092, slack class ii (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 V 1–116（116 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 LMT DODECYL-BETA-D-MALTOSIDE × 10 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.50 Å
8Q0A Inward-facing, closed proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 V 1–116（116 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 16 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 8 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 MG MAGNESIUM ION × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0F Inward-facing, open2 proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 V 1–116（116 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 21 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0J Inward-facing, slack proteoliposome complex I at 3.8 A. Initially purified in DDM. 提交 2023-07-28	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 V 1–116（116 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 4 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.80 Å
8Q0M Outward-facing, closed proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 V 1–116（116 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0O Outward-facing, open2 proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 V 1–116（116 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0Q Outward-facing, slack proteoliposome complex I at 3.6 A. Initially purified in DDM 提交 2023-07-28	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 V 1–116（116 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 4 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.60 Å
8Q1P Inward-facing, open2 proteoliposome complex I at 2.9 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 V 1–116（116 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.90 Å
8Q1U Inward-facing, open1 proteoliposome complex I at 3.3 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 V 1–116（116 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 15 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 5 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.30 Å
8Q1Y Outward-facing, open2 proteoliposome complex I at 2.6 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 V 1–116（116 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 ZN ZINC ION × 2 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q25 Outward-facing, open1 proteoliposome complex I at 2.8 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 V 1–116（116 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 ZN ZINC ION × 2 MG MAGNESIUM ION × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.80 Å
8Q45 Inward-facing, closed proteoliposome complex I at 2.7 A. Initially purified in LMNG. 提交 2023-08-05	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 V 1–116（116 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 16 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.70 Å
8Q46 Inward-facing, open2 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 V 1–116（116 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q47 Inward-facing, open1 proteoliposome complex I at 2.9 A. Initially purified in LMNG. 提交 2023-08-05	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 V 1–116（116 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 15 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 26 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 5 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.90 Å
8Q48 Outward-facing, closed proteoliposome complex I at 2.5 A. Initially purified in LMNG. 提交 2023-08-05	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 V 1–116（116 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 35 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.50 Å
8Q49 Outward-facing, open2 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 V 1–116（116 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CHD CHOLIC ACID × 1 ZN ZINC ION × 2 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 FVH [[(2~{R},3~{S},4~{R},5~{R})-5-[(3~{R})-3-aminocarbonylpiperidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{R},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3-oxidanyl-4-phosphonooxy-oxolan-2-yl]methyl hydrogen phosphate × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q4A Outward-facing, open1 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 V 1–116（116 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
9SMF Reduced bovine complex I in lipid nanodisc, NADH-active-Q10 提交 2025-09-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 V 1–116（116 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 20 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 8 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.51 Å
9SMG Reduced bovine complex I in lipid nanodisc, NADH-active-altQ10 提交 2025-09-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 V 1–116（116 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 18 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.42 Å
9SMH Reduced bovine complex I in lipid nanodisc, NADH-active-DDM 提交 2025-09-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 V 1–116（116 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 17 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 LMT DODECYL-BETA-D-MALTOSIDE × 1 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.61 Å
9SMI Reduced bovine complex I in lipid nanodisc, NADH-deactive 提交 2025-09-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 V 1–116（116 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 27 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 LMT DODECYL-BETA-D-MALTOSIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 5 CHD CHOLIC ACID × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.01 Å
9W2U Cryo-EM structure of complex I on the bovine heart submitochondrial particles, open 提交 2025-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 V 2–116（115 aa）	未记录	FME N-FORMYLMETHIONINE × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 18 CDL CARDIOLIPIN × 6 CHD CHOLIC ACID × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.60 Å
9W2V Cryo-EM structure of complex I on the bovine heart submitochondrial particles, closed 提交 2025-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 V 2–116（115 aa）	未记录	FME N-FORMYLMETHIONINE × 4 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 19 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 12 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 6 MG MAGNESIUM ION × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.80 Å

共 49 个其他 PDB 条目、49 个 assembly。 打开独立比较页并筛选聚集状态

查看构建体与数据证据

UniProt名称	NDUA5_BOVIN
Isoform	—
PDB实体	22
链与序列区间	作者链 V； PDB构建体 1–116； UniProt 1–116

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6

物种未注明

UniProt Q02366

当前结构中的状态

Assembly	聚集状态	构建体	突变与修饰	配体、离子与共同组分	实验方法与环境	结构质量
1	蛋白异源复合物 异源复合物 蛋白 × 45 PDB 声明：45-meric（45） 与蛋白拷贝数一致	链 W； UniProt 1–128	未记录	NADH-ubiquinone oxidoreductase chain 3 × 1 （P03898） NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial × 1 （P42026） NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial × 1 （P23709） NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial × 1 （P17694） NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial × 1 （P04394） NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial × 1 （P25708） ;NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, NDUFS1 ; × 1 （P15690） NADH-ubiquinone oxidoreductase chain 1 × 1 （P03887） NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial × 1 （P42028） NADH-ubiquinone oxidoreductase chain 6 × 1 （P03924） NADH-ubiquinone oxidoreductase chain 4L × 1 （P03902） NADH-ubiquinone oxidoreductase chain 5 × 1 （P03920） NADH-ubiquinone oxidoreductase chain 4 × 1 （P03910） NADH-ubiquinone oxidoreductase chain 2 × 1 （P03892） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, NDUFA10,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial ; × 1 （P34942） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial × 1 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial × 1 ;NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial ; × 1 （P23934） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 × 1 （Q02370） Acyl carrier protein, mitochondrial × 1 （P52505） Acyl carrier protein, mitochondrial × 1 （P52505） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 × 1 （P23935） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 ; × 1 （P42029） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 × 1 （Q8HXG6） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 ; × 1 （Q95KV7） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 × 1 （Q02377） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 ; × 1 （Q02371） NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial × 1 （Q02376） ;NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2 ; × 1 （Q02827） NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 × 1 （Q02379） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 × 1 （Q02378） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial × 1 （Q8HXG5） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial ; × 1 （Q02380） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 ; × 1 （Q02367） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, NDUFB2 × 1 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3, NDUFB3 × 1 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, NDUFB8 × 1 ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 ; × 1 （P48305） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 ; × 1 （Q02369） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 × 1 （Q02368） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10, NDUFB10,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10, NDUFB10 ; × 1 （Q02373） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 × 1 （O97725） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7, NDUFA7 × 1 NADH dehydrogenase [ubiquinone] flavoprotein 3, NDUFV3 × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液：pH 8 cryo-EM玻璃化条件：冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 4.35 Å

数据库中的同蛋白其他状态

以下每一行都是同一 UniProt 蛋白在另一个 PDB 条目中的 biological assembly， “相对当前条目”直接指出证据层面的不同；没有差异标签表示当前已读取字段一致。

其他 PDB	相对当前条目 5LC5	Assembly / 聚集状态	构建体	突变与修饰	配体、离子与非聚合物	实验方法与环境	结构质量
5LDW Structure of mammalian respiratory Complex I, class1 提交 2016-06-28	实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 W 1–128（128 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8；20 mM TRIS-HCL, 150 mM NaCl, 0.03% CYMAL-7 cryo-EM玻璃化条件 冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus present in a cold room, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 4.27 Å
5LDX Structure of mammalian respiratory Complex I, class3. 提交 2016-06-28	构建体不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 W 2–128（127 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 20 mM TRIS-HCL, 150 mM NaCl, 0.03% CYMAL-7；pH 8 cryo-EM玻璃化条件 冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 5.60 Å
5O31 Mitochondrial complex I in the deactive state 提交 2017-05-23	实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 W 1–128（128 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.55 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.13 Å
7DGQ Activity optimized supercomplex state1 提交 2020-11-12	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 O 2–128（127 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 CU COPPER (II) ION × 3 HEA HEME-A × 2 MG MAGNESIUM ION × 1 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 UQ2 UBIQUINONE-2 × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 5.00 Å
7DGR Activity optimized supercomplex state2 提交 2020-11-12	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 O 2–128（127 aa）	未记录	FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 3 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.60 Å
7DGS Activity optimized supercomplex state3 提交 2020-11-12	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 O 2–128（127 aa）	未记录	FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 7.80 Å
7DGZ Activity optimized complex I (closed form) 提交 2020-11-12	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 O 2–128（127 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 2 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 3.80 Å
7DH0 Activity optimized complex I (open form) 提交 2020-11-12	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 O 2–128（127 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.20 Å
7DKF Activity optimized supercomplex state4 提交 2020-11-24	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 O2 2–128（127 aa）	未记录	HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 8.30 Å
7QSD Bovine complex I in the active state at 3.1 A 提交 2022-01-13	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 W 1–128（128 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 13 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 CDL CARDIOLIPIN × 4 LMT DODECYL-BETA-D-MALTOSIDE × 3 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 3.10 Å
7QSK Bovine complex I in lipid nanodisc, Active-Q10 提交 2022-01-13	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 W 1–128（128 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 19 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.84 Å
7QSL Bovine complex I in lipid nanodisc, Active-apo 提交 2022-01-13	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 W 1–128（128 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 20 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 8 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.76 Å
7QSM Bovine complex I in lipid nanodisc, Deactive-ligand (composite) 提交 2022-01-13	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 W 1–128（128 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 GOL GLYCEROL × 1 LMT DODECYL-BETA-D-MALTOSIDE × 1 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.30 Å
7QSN Bovine complex I in lipid nanodisc, Deactive-apo 提交 2022-01-13	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 W 1–128（128 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 6 CHD CHOLIC ACID × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.81 Å
7QSO Bovine complex I in lipid nanodisc, State 3 (Slack) 提交 2022-01-13	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 W 1–128（128 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 6 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CHD CHOLIC ACID × 2 CDL CARDIOLIPIN × 6 U10 UBIQUINONE-10 × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 3.02 Å
7R41 Bovine complex I in the presence of IM1761092, active class i (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 W 1–128（128 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 16 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R42 Bovine complex I in the presence of IM1761092, active class ii (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 W 1–128（128 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 17 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R43 Bovine complex I in the presence of IM1761092, active class iii (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 W 1–128（128 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 CDL CARDIOLIPIN × 5 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R44 Bovine complex I in the presence of IM1761092, active class iv (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 W 1–128（128 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 11 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R45 Bovine complex I in the presence of IM1761092, deactive class i (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 W 1–128（128 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R46 Bovine complex I in the presence of IM1761092, deactive class ii (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 W 1–128（128 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 11 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R47 Bovine complex I in the presence of IM1761092, deactive class iii (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 W 1–128（128 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R48 Bovine complex I in the presence of IM1761092, deactive class iv (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 W 1–128（128 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 15 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 13 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4C Bovine complex I in the presence of IM1761092, deactive class v (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 W 1–128（128 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 12 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4D Bovine complex I in the presence of IM1761092, deactive class vi (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 W 1–128（128 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4F Bovine complex I in the presence of IM1761092, slack class i (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 W 1–128（128 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 7 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 3 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 CDL CARDIOLIPIN × 6 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R4G Bovine complex I in the presence of IM1761092, slack class ii (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 W 1–128（128 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 LMT DODECYL-BETA-D-MALTOSIDE × 10 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.50 Å
8Q0A Inward-facing, closed proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 W 1–128（128 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 16 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 8 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 MG MAGNESIUM ION × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0F Inward-facing, open2 proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 W 1–128（128 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 21 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0J Inward-facing, slack proteoliposome complex I at 3.8 A. Initially purified in DDM. 提交 2023-07-28	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 W 1–128（128 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 4 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.80 Å
8Q0M Outward-facing, closed proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 W 1–128（128 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0O Outward-facing, open2 proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 W 1–128（128 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0Q Outward-facing, slack proteoliposome complex I at 3.6 A. Initially purified in DDM 提交 2023-07-28	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 W 1–128（128 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 4 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.60 Å
8Q1P Inward-facing, open2 proteoliposome complex I at 2.9 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 W 1–128（128 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.90 Å
8Q1U Inward-facing, open1 proteoliposome complex I at 3.3 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 W 1–128（128 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 15 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 5 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.30 Å
8Q1Y Outward-facing, open2 proteoliposome complex I at 2.6 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 W 1–128（128 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 ZN ZINC ION × 2 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q25 Outward-facing, open1 proteoliposome complex I at 2.8 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 W 1–128（128 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 ZN ZINC ION × 2 MG MAGNESIUM ION × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.80 Å
8Q45 Inward-facing, closed proteoliposome complex I at 2.7 A. Initially purified in LMNG. 提交 2023-08-05	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 W 1–128（128 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 16 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.70 Å
8Q46 Inward-facing, open2 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 W 1–128（128 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q47 Inward-facing, open1 proteoliposome complex I at 2.9 A. Initially purified in LMNG. 提交 2023-08-05	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 W 1–128（128 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 15 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 26 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 5 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.90 Å
8Q48 Outward-facing, closed proteoliposome complex I at 2.5 A. Initially purified in LMNG. 提交 2023-08-05	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 W 1–128（128 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 35 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.50 Å
8Q49 Outward-facing, open2 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 W 1–128（128 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CHD CHOLIC ACID × 1 ZN ZINC ION × 2 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 FVH [[(2~{R},3~{S},4~{R},5~{R})-5-[(3~{R})-3-aminocarbonylpiperidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{R},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3-oxidanyl-4-phosphonooxy-oxolan-2-yl]methyl hydrogen phosphate × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q4A Outward-facing, open1 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 W 1–128（128 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
9SMF Reduced bovine complex I in lipid nanodisc, NADH-active-Q10 提交 2025-09-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 W 1–128（128 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 20 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 8 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.51 Å
9SMG Reduced bovine complex I in lipid nanodisc, NADH-active-altQ10 提交 2025-09-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 W 1–128（128 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 18 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.42 Å
9SMH Reduced bovine complex I in lipid nanodisc, NADH-active-DDM 提交 2025-09-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 W 1–128（128 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 17 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 LMT DODECYL-BETA-D-MALTOSIDE × 1 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.61 Å
9SMI Reduced bovine complex I in lipid nanodisc, NADH-deactive 提交 2025-09-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 W 1–128（128 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 27 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 LMT DODECYL-BETA-D-MALTOSIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 5 CHD CHOLIC ACID × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.01 Å
9W2U Cryo-EM structure of complex I on the bovine heart submitochondrial particles, open 提交 2025-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 W 14–128（115 aa）	未记录	FME N-FORMYLMETHIONINE × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 18 CDL CARDIOLIPIN × 6 CHD CHOLIC ACID × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.60 Å
9W2V Cryo-EM structure of complex I on the bovine heart submitochondrial particles, closed 提交 2025-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 W 14–128（115 aa）	未记录	FME N-FORMYLMETHIONINE × 4 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 19 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 12 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 6 MG MAGNESIUM ION × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.80 Å

共 49 个其他 PDB 条目、49 个 assembly。 打开独立比较页并筛选聚集状态

查看构建体与数据证据

UniProt名称	NDUA6_BOVIN
Isoform	—
PDB实体	23
链与序列区间	作者链 W； PDB构建体 1–128； UniProt 1–128

;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 ;

物种未注明

UniProt P42029

当前结构中的状态

Assembly	聚集状态	构建体	突变与修饰	配体、离子与共同组分	实验方法与环境	结构质量
1	蛋白异源复合物 异源复合物 蛋白 × 45 PDB 声明：45-meric（45） 与蛋白拷贝数一致	链 X； UniProt 1–114	未记录	NADH-ubiquinone oxidoreductase chain 3 × 1 （P03898） NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial × 1 （P42026） NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial × 1 （P23709） NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial × 1 （P17694） NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial × 1 （P04394） NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial × 1 （P25708） ;NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, NDUFS1 ; × 1 （P15690） NADH-ubiquinone oxidoreductase chain 1 × 1 （P03887） NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial × 1 （P42028） NADH-ubiquinone oxidoreductase chain 6 × 1 （P03924） NADH-ubiquinone oxidoreductase chain 4L × 1 （P03902） NADH-ubiquinone oxidoreductase chain 5 × 1 （P03920） NADH-ubiquinone oxidoreductase chain 4 × 1 （P03910） NADH-ubiquinone oxidoreductase chain 2 × 1 （P03892） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, NDUFA10,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial ; × 1 （P34942） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial × 1 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial × 1 ;NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial ; × 1 （P23934） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 × 1 （Q02370） Acyl carrier protein, mitochondrial × 1 （P52505） Acyl carrier protein, mitochondrial × 1 （P52505） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 × 1 （P23935） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 × 1 （Q02366） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 × 1 （Q8HXG6） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 ; × 1 （Q95KV7） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 × 1 （Q02377） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 ; × 1 （Q02371） NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial × 1 （Q02376） ;NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2 ; × 1 （Q02827） NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 × 1 （Q02379） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 × 1 （Q02378） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial × 1 （Q8HXG5） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial ; × 1 （Q02380） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 ; × 1 （Q02367） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, NDUFB2 × 1 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3, NDUFB3 × 1 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, NDUFB8 × 1 ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 ; × 1 （P48305） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 ; × 1 （Q02369） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 × 1 （Q02368） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10, NDUFB10,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10, NDUFB10 ; × 1 （Q02373） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 × 1 （O97725） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7, NDUFA7 × 1 NADH dehydrogenase [ubiquinone] flavoprotein 3, NDUFV3 × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液：pH 8 cryo-EM玻璃化条件：冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 4.35 Å

数据库中的同蛋白其他状态

以下每一行都是同一 UniProt 蛋白在另一个 PDB 条目中的 biological assembly， “相对当前条目”直接指出证据层面的不同；没有差异标签表示当前已读取字段一致。

其他 PDB	相对当前条目 5LC5	Assembly / 聚集状态	构建体	突变与修饰	配体、离子与非聚合物	实验方法与环境	结构质量
5LDW Structure of mammalian respiratory Complex I, class1 提交 2016-06-28	实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 X 1–114（114 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8；20 mM TRIS-HCL, 150 mM NaCl, 0.03% CYMAL-7 cryo-EM玻璃化条件 冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus present in a cold room, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 4.27 Å
5LDX Structure of mammalian respiratory Complex I, class3. 提交 2016-06-28	构建体不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 X 6–114（109 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 20 mM TRIS-HCL, 150 mM NaCl, 0.03% CYMAL-7；pH 8 cryo-EM玻璃化条件 冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 5.60 Å
5O31 Mitochondrial complex I in the deactive state 提交 2017-05-23	构建体不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 X 2–172（171 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.55 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.13 Å
7DGQ Activity optimized supercomplex state1 提交 2020-11-12	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 Q 2–172（171 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 CU COPPER (II) ION × 3 HEA HEME-A × 2 MG MAGNESIUM ION × 1 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 UQ2 UBIQUINONE-2 × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 5.00 Å
7DGR Activity optimized supercomplex state2 提交 2020-11-12	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 Q 2–172（171 aa）	未记录	FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 3 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.60 Å
7DGS Activity optimized supercomplex state3 提交 2020-11-12	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 Q 2–172（171 aa）	未记录	FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 7.80 Å
7DGZ Activity optimized complex I (closed form) 提交 2020-11-12	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 Q 2–172（171 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 2 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 3.80 Å
7DH0 Activity optimized complex I (open form) 提交 2020-11-12	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 Q 2–172（171 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.20 Å
7DKF Activity optimized supercomplex state4 提交 2020-11-24	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 Q2 2–172（171 aa）	未记录	HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 8.30 Å
7QSD Bovine complex I in the active state at 3.1 A 提交 2022-01-13	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 X 1–172（172 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 13 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 CDL CARDIOLIPIN × 4 LMT DODECYL-BETA-D-MALTOSIDE × 3 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 3.10 Å
7QSK Bovine complex I in lipid nanodisc, Active-Q10 提交 2022-01-13	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 X 1–172（172 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 19 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.84 Å
7QSL Bovine complex I in lipid nanodisc, Active-apo 提交 2022-01-13	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 X 1–172（172 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 20 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 8 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.76 Å
7QSM Bovine complex I in lipid nanodisc, Deactive-ligand (composite) 提交 2022-01-13	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 X 1–172（172 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 GOL GLYCEROL × 1 LMT DODECYL-BETA-D-MALTOSIDE × 1 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.30 Å
7QSN Bovine complex I in lipid nanodisc, Deactive-apo 提交 2022-01-13	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 X 1–172（172 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 6 CHD CHOLIC ACID × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.81 Å
7QSO Bovine complex I in lipid nanodisc, State 3 (Slack) 提交 2022-01-13	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 X 1–172（172 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 6 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CHD CHOLIC ACID × 2 CDL CARDIOLIPIN × 6 U10 UBIQUINONE-10 × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 3.02 Å
7R41 Bovine complex I in the presence of IM1761092, active class i (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 X 1–172（172 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 16 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R42 Bovine complex I in the presence of IM1761092, active class ii (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 X 1–172（172 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 17 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R43 Bovine complex I in the presence of IM1761092, active class iii (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 X 1–172（172 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 CDL CARDIOLIPIN × 5 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R44 Bovine complex I in the presence of IM1761092, active class iv (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 X 1–172（172 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 11 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R45 Bovine complex I in the presence of IM1761092, deactive class i (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 X 1–172（172 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R46 Bovine complex I in the presence of IM1761092, deactive class ii (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 X 1–172（172 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 11 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R47 Bovine complex I in the presence of IM1761092, deactive class iii (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 X 1–172（172 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R48 Bovine complex I in the presence of IM1761092, deactive class iv (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 X 1–172（172 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 15 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 13 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4C Bovine complex I in the presence of IM1761092, deactive class v (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 X 1–172（172 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 12 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4D Bovine complex I in the presence of IM1761092, deactive class vi (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 X 1–172（172 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4F Bovine complex I in the presence of IM1761092, slack class i (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 X 1–172（172 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 7 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 3 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 CDL CARDIOLIPIN × 6 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R4G Bovine complex I in the presence of IM1761092, slack class ii (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 X 1–172（172 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 LMT DODECYL-BETA-D-MALTOSIDE × 10 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.50 Å
8Q0A Inward-facing, closed proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 X 1–172（172 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 16 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 8 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 MG MAGNESIUM ION × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0F Inward-facing, open2 proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 X 1–172（172 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 21 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0J Inward-facing, slack proteoliposome complex I at 3.8 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 X 1–172（172 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 4 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.80 Å
8Q0M Outward-facing, closed proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 X 1–172（172 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0O Outward-facing, open2 proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 X 1–172（172 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0Q Outward-facing, slack proteoliposome complex I at 3.6 A. Initially purified in DDM 提交 2023-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 X 1–172（172 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 4 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.60 Å
8Q1P Inward-facing, open2 proteoliposome complex I at 2.9 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 X 1–172（172 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.90 Å
8Q1U Inward-facing, open1 proteoliposome complex I at 3.3 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 X 1–172（172 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 15 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 5 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.30 Å
8Q1Y Outward-facing, open2 proteoliposome complex I at 2.6 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 X 1–172（172 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 ZN ZINC ION × 2 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q25 Outward-facing, open1 proteoliposome complex I at 2.8 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 X 1–172（172 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 ZN ZINC ION × 2 MG MAGNESIUM ION × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.80 Å
8Q45 Inward-facing, closed proteoliposome complex I at 2.7 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 X 1–172（172 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 16 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.70 Å
8Q46 Inward-facing, open2 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 X 1–172（172 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q47 Inward-facing, open1 proteoliposome complex I at 2.9 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 X 1–172（172 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 15 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 26 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 5 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.90 Å
8Q48 Outward-facing, closed proteoliposome complex I at 2.5 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 X 1–172（172 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 35 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.50 Å
8Q49 Outward-facing, open2 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 X 1–172（172 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CHD CHOLIC ACID × 1 ZN ZINC ION × 2 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 FVH [[(2~{R},3~{S},4~{R},5~{R})-5-[(3~{R})-3-aminocarbonylpiperidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{R},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3-oxidanyl-4-phosphonooxy-oxolan-2-yl]methyl hydrogen phosphate × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q4A Outward-facing, open1 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 X 1–172（172 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
9SMF Reduced bovine complex I in lipid nanodisc, NADH-active-Q10 提交 2025-09-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 X 1–172（172 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 20 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 8 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.51 Å
9SMG Reduced bovine complex I in lipid nanodisc, NADH-active-altQ10 提交 2025-09-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 X 1–172（172 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 18 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.42 Å
9SMH Reduced bovine complex I in lipid nanodisc, NADH-active-DDM 提交 2025-09-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 X 1–172（172 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 17 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 LMT DODECYL-BETA-D-MALTOSIDE × 1 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.61 Å
9SMI Reduced bovine complex I in lipid nanodisc, NADH-deactive 提交 2025-09-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 X 1–172（172 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 27 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 LMT DODECYL-BETA-D-MALTOSIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 5 CHD CHOLIC ACID × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.01 Å
9W2U Cryo-EM structure of complex I on the bovine heart submitochondrial particles, open 提交 2025-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 X 2–172（171 aa）	未记录	FME N-FORMYLMETHIONINE × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 18 CDL CARDIOLIPIN × 6 CHD CHOLIC ACID × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.60 Å
9W2V Cryo-EM structure of complex I on the bovine heart submitochondrial particles, closed 提交 2025-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 X 2–172（171 aa）	未记录	FME N-FORMYLMETHIONINE × 4 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 19 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 12 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 6 MG MAGNESIUM ION × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.80 Å

共 49 个其他 PDB 条目、49 个 assembly。 打开独立比较页并筛选聚集状态

查看构建体与数据证据

UniProt名称	NDUA8_BOVIN
Isoform	—
PDB实体	24
链与序列区间	作者链 X； PDB构建体 1–114； UniProt 1–114

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11

物种未注明

UniProt Q8HXG6

当前结构中的状态

Assembly	聚集状态	构建体	突变与修饰	配体、离子与共同组分	实验方法与环境	结构质量
1	蛋白异源复合物 异源复合物 蛋白 × 45 PDB 声明：45-meric（45） 与蛋白拷贝数一致	链 Y； UniProt 2–139	未记录	NADH-ubiquinone oxidoreductase chain 3 × 1 （P03898） NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial × 1 （P42026） NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial × 1 （P23709） NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial × 1 （P17694） NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial × 1 （P04394） NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial × 1 （P25708） ;NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, NDUFS1 ; × 1 （P15690） NADH-ubiquinone oxidoreductase chain 1 × 1 （P03887） NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial × 1 （P42028） NADH-ubiquinone oxidoreductase chain 6 × 1 （P03924） NADH-ubiquinone oxidoreductase chain 4L × 1 （P03902） NADH-ubiquinone oxidoreductase chain 5 × 1 （P03920） NADH-ubiquinone oxidoreductase chain 4 × 1 （P03910） NADH-ubiquinone oxidoreductase chain 2 × 1 （P03892） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, NDUFA10,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial ; × 1 （P34942） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial × 1 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial × 1 ;NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial ; × 1 （P23934） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 × 1 （Q02370） Acyl carrier protein, mitochondrial × 1 （P52505） Acyl carrier protein, mitochondrial × 1 （P52505） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 × 1 （P23935） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 × 1 （Q02366） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 ; × 1 （P42029） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 ; × 1 （Q95KV7） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 × 1 （Q02377） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 ; × 1 （Q02371） NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial × 1 （Q02376） ;NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2 ; × 1 （Q02827） NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 × 1 （Q02379） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 × 1 （Q02378） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial × 1 （Q8HXG5） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial ; × 1 （Q02380） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 ; × 1 （Q02367） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, NDUFB2 × 1 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3, NDUFB3 × 1 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, NDUFB8 × 1 ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 ; × 1 （P48305） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 ; × 1 （Q02369） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 × 1 （Q02368） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10, NDUFB10,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10, NDUFB10 ; × 1 （Q02373） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 × 1 （O97725） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7, NDUFA7 × 1 NADH dehydrogenase [ubiquinone] flavoprotein 3, NDUFV3 × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液：pH 8 cryo-EM玻璃化条件：冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 4.35 Å

数据库中的同蛋白其他状态

以下每一行都是同一 UniProt 蛋白在另一个 PDB 条目中的 biological assembly， “相对当前条目”直接指出证据层面的不同；没有差异标签表示当前已读取字段一致。

其他 PDB	相对当前条目 5LC5	Assembly / 聚集状态	构建体	突变与修饰	配体、离子与非聚合物	实验方法与环境	结构质量
5LDW Structure of mammalian respiratory Complex I, class1 提交 2016-06-28	构建体不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 Y 1–141（141 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8；20 mM TRIS-HCL, 150 mM NaCl, 0.03% CYMAL-7 cryo-EM玻璃化条件 冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus present in a cold room, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 4.27 Å
5LDX Structure of mammalian respiratory Complex I, class3. 提交 2016-06-28	构建体不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 Y 2–141（140 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 20 mM TRIS-HCL, 150 mM NaCl, 0.03% CYMAL-7；pH 8 cryo-EM玻璃化条件 冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 5.60 Å
5O31 Mitochondrial complex I in the deactive state 提交 2017-05-23	构建体不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 Y 1–141（141 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.55 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.13 Å
7DGQ Activity optimized supercomplex state1 提交 2020-11-12	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 T 2–141（140 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 CU COPPER (II) ION × 3 HEA HEME-A × 2 MG MAGNESIUM ION × 1 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 UQ2 UBIQUINONE-2 × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 5.00 Å
7DGR Activity optimized supercomplex state2 提交 2020-11-12	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 T 2–141（140 aa）	未记录	FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 3 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.60 Å
7DGS Activity optimized supercomplex state3 提交 2020-11-12	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 T 2–141（140 aa）	未记录	FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 7.80 Å
7DGZ Activity optimized complex I (closed form) 提交 2020-11-12	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 T 2–141（140 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 2 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 3.80 Å
7DH0 Activity optimized complex I (open form) 提交 2020-11-12	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 T 2–141（140 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.20 Å
7DKF Activity optimized supercomplex state4 提交 2020-11-24	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 T2 2–141（140 aa）	未记录	HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 8.30 Å
7QSD Bovine complex I in the active state at 3.1 A 提交 2022-01-13	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 Y 1–141（141 aa）	非标准单体：是（mmCIF未提供具体位点）	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 13 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 CDL CARDIOLIPIN × 4 LMT DODECYL-BETA-D-MALTOSIDE × 3 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 3.10 Å
7QSK Bovine complex I in lipid nanodisc, Active-Q10 提交 2022-01-13	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 Y 1–141（141 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 19 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.84 Å
7QSL Bovine complex I in lipid nanodisc, Active-apo 提交 2022-01-13	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 Y 1–141（141 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 20 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 8 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.76 Å
7QSM Bovine complex I in lipid nanodisc, Deactive-ligand (composite) 提交 2022-01-13	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 Y 1–141（141 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 GOL GLYCEROL × 1 LMT DODECYL-BETA-D-MALTOSIDE × 1 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.30 Å
7QSN Bovine complex I in lipid nanodisc, Deactive-apo 提交 2022-01-13	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 Y 1–141（141 aa）	非标准单体：是（mmCIF未提供具体位点）	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 6 CHD CHOLIC ACID × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.81 Å
7QSO Bovine complex I in lipid nanodisc, State 3 (Slack) 提交 2022-01-13	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 Y 1–141（141 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 6 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CHD CHOLIC ACID × 2 CDL CARDIOLIPIN × 6 U10 UBIQUINONE-10 × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 3.02 Å
7R41 Bovine complex I in the presence of IM1761092, active class i (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 Y 1–141（141 aa）	非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 16 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R42 Bovine complex I in the presence of IM1761092, active class ii (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 Y 1–141（141 aa）	非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 17 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R43 Bovine complex I in the presence of IM1761092, active class iii (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 Y 1–141（141 aa）	非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 CDL CARDIOLIPIN × 5 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R44 Bovine complex I in the presence of IM1761092, active class iv (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 Y 1–141（141 aa）	非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 11 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R45 Bovine complex I in the presence of IM1761092, deactive class i (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 Y 1–141（141 aa）	非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R46 Bovine complex I in the presence of IM1761092, deactive class ii (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 Y 1–141（141 aa）	非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 11 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R47 Bovine complex I in the presence of IM1761092, deactive class iii (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 Y 1–141（141 aa）	非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R48 Bovine complex I in the presence of IM1761092, deactive class iv (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 Y 1–141（141 aa）	非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 15 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 13 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4C Bovine complex I in the presence of IM1761092, deactive class v (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 Y 1–141（141 aa）	非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 12 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4D Bovine complex I in the presence of IM1761092, deactive class vi (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 Y 1–141（141 aa）	非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4F Bovine complex I in the presence of IM1761092, slack class i (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 Y 1–141（141 aa）	非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 7 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 3 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 CDL CARDIOLIPIN × 6 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R4G Bovine complex I in the presence of IM1761092, slack class ii (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 Y 1–141（141 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 LMT DODECYL-BETA-D-MALTOSIDE × 10 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.50 Å
8Q0A Inward-facing, closed proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 Y 1–141（141 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 16 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 8 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 MG MAGNESIUM ION × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0F Inward-facing, open2 proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 Y 1–141（141 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 21 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0J Inward-facing, slack proteoliposome complex I at 3.8 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 Y 1–141（141 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 4 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.80 Å
8Q0M Outward-facing, closed proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 Y 1–141（141 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0O Outward-facing, open2 proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 Y 1–141（141 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0Q Outward-facing, slack proteoliposome complex I at 3.6 A. Initially purified in DDM 提交 2023-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 Y 1–141（141 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 4 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.60 Å
8Q1P Inward-facing, open2 proteoliposome complex I at 2.9 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 Y 1–141（141 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.90 Å
8Q1U Inward-facing, open1 proteoliposome complex I at 3.3 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 Y 1–141（141 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 15 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 5 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.30 Å
8Q1Y Outward-facing, open2 proteoliposome complex I at 2.6 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 Y 1–141（141 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 ZN ZINC ION × 2 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q25 Outward-facing, open1 proteoliposome complex I at 2.8 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 Y 1–141（141 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 ZN ZINC ION × 2 MG MAGNESIUM ION × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.80 Å
8Q45 Inward-facing, closed proteoliposome complex I at 2.7 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 Y 1–141（141 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 16 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.70 Å
8Q46 Inward-facing, open2 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 Y 1–141（141 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q47 Inward-facing, open1 proteoliposome complex I at 2.9 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 Y 1–141（141 aa）	非标准单体：是（mmCIF未提供具体位点）	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 15 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 26 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 5 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.90 Å
8Q48 Outward-facing, closed proteoliposome complex I at 2.5 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 Y 1–141（141 aa）	非标准单体：是（mmCIF未提供具体位点）	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 35 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.50 Å
8Q49 Outward-facing, open2 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 Y 1–141（141 aa）	非标准单体：是（mmCIF未提供具体位点）	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CHD CHOLIC ACID × 1 ZN ZINC ION × 2 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 FVH [[(2~{R},3~{S},4~{R},5~{R})-5-[(3~{R})-3-aminocarbonylpiperidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{R},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3-oxidanyl-4-phosphonooxy-oxolan-2-yl]methyl hydrogen phosphate × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q4A Outward-facing, open1 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 Y 1–141（141 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
9SMF Reduced bovine complex I in lipid nanodisc, NADH-active-Q10 提交 2025-09-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 Y 2–141（140 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 20 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 8 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.51 Å
9SMG Reduced bovine complex I in lipid nanodisc, NADH-active-altQ10 提交 2025-09-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 Y 2–141（140 aa）	非标准单体：是（mmCIF未提供具体位点）	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 18 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.42 Å
9SMH Reduced bovine complex I in lipid nanodisc, NADH-active-DDM 提交 2025-09-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 Y 2–141（140 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 17 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 LMT DODECYL-BETA-D-MALTOSIDE × 1 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.61 Å
9SMI Reduced bovine complex I in lipid nanodisc, NADH-deactive 提交 2025-09-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 Y 2–141（140 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 27 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 LMT DODECYL-BETA-D-MALTOSIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 5 CHD CHOLIC ACID × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.01 Å
9W2U Cryo-EM structure of complex I on the bovine heart submitochondrial particles, open 提交 2025-07-28	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 t 2–141（140 aa）	非标准单体：是（mmCIF未提供具体位点）	FME N-FORMYLMETHIONINE × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 18 CDL CARDIOLIPIN × 6 CHD CHOLIC ACID × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.60 Å
9W2V Cryo-EM structure of complex I on the bovine heart submitochondrial particles, closed 提交 2025-07-28	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 Y 2–141（140 aa）	非标准单体：是（mmCIF未提供具体位点）	FME N-FORMYLMETHIONINE × 4 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 19 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 12 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 6 MG MAGNESIUM ION × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.80 Å

共 49 个其他 PDB 条目、49 个 assembly。 打开独立比较页并筛选聚集状态

查看构建体与数据证据

UniProt名称	NDUAB_BOVIN
Isoform	—
PDB实体	25
链与序列区间	作者链 Y； PDB构建体 1–138； UniProt 2–139

;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 ;

物种未注明

UniProt Q95KV7

当前结构中的状态

Assembly	聚集状态	构建体	突变与修饰	配体、离子与共同组分	实验方法与环境	结构质量
1	蛋白异源复合物 异源复合物 蛋白 × 45 PDB 声明：45-meric（45） 与蛋白拷贝数一致	链 Z； UniProt 32–100	未记录	NADH-ubiquinone oxidoreductase chain 3 × 1 （P03898） NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial × 1 （P42026） NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial × 1 （P23709） NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial × 1 （P17694） NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial × 1 （P04394） NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial × 1 （P25708） ;NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, NDUFS1 ; × 1 （P15690） NADH-ubiquinone oxidoreductase chain 1 × 1 （P03887） NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial × 1 （P42028） NADH-ubiquinone oxidoreductase chain 6 × 1 （P03924） NADH-ubiquinone oxidoreductase chain 4L × 1 （P03902） NADH-ubiquinone oxidoreductase chain 5 × 1 （P03920） NADH-ubiquinone oxidoreductase chain 4 × 1 （P03910） NADH-ubiquinone oxidoreductase chain 2 × 1 （P03892） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, NDUFA10,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial ; × 1 （P34942） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial × 1 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial × 1 ;NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial ; × 1 （P23934） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 × 1 （Q02370） Acyl carrier protein, mitochondrial × 1 （P52505） Acyl carrier protein, mitochondrial × 1 （P52505） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 × 1 （P23935） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 × 1 （Q02366） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 ; × 1 （P42029） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 × 1 （Q8HXG6） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 × 1 （Q02377） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 ; × 1 （Q02371） NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial × 1 （Q02376） ;NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2 ; × 1 （Q02827） NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 × 1 （Q02379） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 × 1 （Q02378） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial × 1 （Q8HXG5） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial ; × 1 （Q02380） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 ; × 1 （Q02367） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, NDUFB2 × 1 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3, NDUFB3 × 1 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, NDUFB8 × 1 ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 ; × 1 （P48305） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 ; × 1 （Q02369） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 × 1 （Q02368） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10, NDUFB10,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10, NDUFB10 ; × 1 （Q02373） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 × 1 （O97725） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7, NDUFA7 × 1 NADH dehydrogenase [ubiquinone] flavoprotein 3, NDUFV3 × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液：pH 8 cryo-EM玻璃化条件：冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 4.35 Å

数据库中的同蛋白其他状态

以下每一行都是同一 UniProt 蛋白在另一个 PDB 条目中的 biological assembly， “相对当前条目”直接指出证据层面的不同；没有差异标签表示当前已读取字段一致。

其他 PDB	相对当前条目 5LC5	Assembly / 聚集状态	构建体	突变与修饰	配体、离子与非聚合物	实验方法与环境	结构质量
5LDW Structure of mammalian respiratory Complex I, class1 提交 2016-06-28	实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 Z 32–100（69 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8；20 mM TRIS-HCL, 150 mM NaCl, 0.03% CYMAL-7 cryo-EM玻璃化条件 冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus present in a cold room, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 4.27 Å
5LDX Structure of mammalian respiratory Complex I, class3. 提交 2016-06-28	结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 Z 32–100（69 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 20 mM TRIS-HCL, 150 mM NaCl, 0.03% CYMAL-7；pH 8 cryo-EM玻璃化条件 冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 5.60 Å
5O31 Mitochondrial complex I in the deactive state 提交 2017-05-23	构建体不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 Z 1–99（99 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.55 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.13 Å
7DGQ Activity optimized supercomplex state1 提交 2020-11-12	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 V 2–144（143 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 CU COPPER (II) ION × 3 HEA HEME-A × 2 MG MAGNESIUM ION × 1 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 UQ2 UBIQUINONE-2 × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 5.00 Å
7DGR Activity optimized supercomplex state2 提交 2020-11-12	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 V 2–144（143 aa）	未记录	FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 3 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.60 Å
7DGS Activity optimized supercomplex state3 提交 2020-11-12	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 V 2–144（143 aa）	未记录	FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 7.80 Å
7DGZ Activity optimized complex I (closed form) 提交 2020-11-12	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 V 2–144（143 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 2 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 3.80 Å
7DH0 Activity optimized complex I (open form) 提交 2020-11-12	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 V 2–144（143 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.20 Å
7DKF Activity optimized supercomplex state4 提交 2020-11-24	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 V2 2–144（143 aa）	未记录	HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 8.30 Å
7QSD Bovine complex I in the active state at 3.1 A 提交 2022-01-13	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 Z 1–144（144 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 13 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 CDL CARDIOLIPIN × 4 LMT DODECYL-BETA-D-MALTOSIDE × 3 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 3.10 Å
7QSK Bovine complex I in lipid nanodisc, Active-Q10 提交 2022-01-13	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 Z 1–144（144 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 19 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.84 Å
7QSL Bovine complex I in lipid nanodisc, Active-apo 提交 2022-01-13	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 Z 1–144（144 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 20 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 8 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.76 Å
7QSM Bovine complex I in lipid nanodisc, Deactive-ligand (composite) 提交 2022-01-13	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 Z 1–144（144 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 GOL GLYCEROL × 1 LMT DODECYL-BETA-D-MALTOSIDE × 1 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.30 Å
7QSN Bovine complex I in lipid nanodisc, Deactive-apo 提交 2022-01-13	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 Z 1–144（144 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 6 CHD CHOLIC ACID × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.81 Å
7QSO Bovine complex I in lipid nanodisc, State 3 (Slack) 提交 2022-01-13	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 Z 1–144（144 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 6 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CHD CHOLIC ACID × 2 CDL CARDIOLIPIN × 6 U10 UBIQUINONE-10 × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 3.02 Å
7R41 Bovine complex I in the presence of IM1761092, active class i (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 Z 1–144（144 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 16 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R42 Bovine complex I in the presence of IM1761092, active class ii (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 Z 1–144（144 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 17 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R43 Bovine complex I in the presence of IM1761092, active class iii (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 Z 1–144（144 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 CDL CARDIOLIPIN × 5 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R44 Bovine complex I in the presence of IM1761092, active class iv (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 Z 1–144（144 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 11 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R45 Bovine complex I in the presence of IM1761092, deactive class i (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 Z 1–144（144 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R46 Bovine complex I in the presence of IM1761092, deactive class ii (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 Z 1–144（144 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 11 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R47 Bovine complex I in the presence of IM1761092, deactive class iii (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 Z 1–144（144 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R48 Bovine complex I in the presence of IM1761092, deactive class iv (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 Z 1–144（144 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 15 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 13 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4C Bovine complex I in the presence of IM1761092, deactive class v (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 Z 1–144（144 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 12 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4D Bovine complex I in the presence of IM1761092, deactive class vi (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 Z 1–144（144 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4F Bovine complex I in the presence of IM1761092, slack class i (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 Z 1–144（144 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 7 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 3 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 CDL CARDIOLIPIN × 6 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R4G Bovine complex I in the presence of IM1761092, slack class ii (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 Z 1–144（144 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 LMT DODECYL-BETA-D-MALTOSIDE × 10 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.50 Å
8Q0A Inward-facing, closed proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 Z 1–144（144 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 16 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 8 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 MG MAGNESIUM ION × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0F Inward-facing, open2 proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 Z 1–144（144 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 21 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0J Inward-facing, slack proteoliposome complex I at 3.8 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 Z 1–144（144 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 4 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.80 Å
8Q0M Outward-facing, closed proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 Z 1–144（144 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0O Outward-facing, open2 proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 Z 1–144（144 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0Q Outward-facing, slack proteoliposome complex I at 3.6 A. Initially purified in DDM 提交 2023-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 Z 1–144（144 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 4 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.60 Å
8Q1P Inward-facing, open2 proteoliposome complex I at 2.9 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 Z 1–144（144 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.90 Å
8Q1U Inward-facing, open1 proteoliposome complex I at 3.3 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 Z 1–144（144 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 15 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 5 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.30 Å
8Q1Y Outward-facing, open2 proteoliposome complex I at 2.6 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 Z 1–144（144 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 ZN ZINC ION × 2 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q25 Outward-facing, open1 proteoliposome complex I at 2.8 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 Z 1–144（144 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 ZN ZINC ION × 2 MG MAGNESIUM ION × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.80 Å
8Q45 Inward-facing, closed proteoliposome complex I at 2.7 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 Z 1–144（144 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 16 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.70 Å
8Q46 Inward-facing, open2 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 Z 1–144（144 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q47 Inward-facing, open1 proteoliposome complex I at 2.9 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 Z 1–144（144 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 15 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 26 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 5 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.90 Å
8Q48 Outward-facing, closed proteoliposome complex I at 2.5 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 Z 1–144（144 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 35 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.50 Å
8Q49 Outward-facing, open2 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 Z 1–144（144 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CHD CHOLIC ACID × 1 ZN ZINC ION × 2 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 FVH [[(2~{R},3~{S},4~{R},5~{R})-5-[(3~{R})-3-aminocarbonylpiperidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{R},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3-oxidanyl-4-phosphonooxy-oxolan-2-yl]methyl hydrogen phosphate × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q4A Outward-facing, open1 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 Z 1–144（144 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
9SMF Reduced bovine complex I in lipid nanodisc, NADH-active-Q10 提交 2025-09-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 Z 1–144（144 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 20 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 8 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.51 Å
9SMG Reduced bovine complex I in lipid nanodisc, NADH-active-altQ10 提交 2025-09-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 Z 1–144（144 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 18 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.42 Å
9SMH Reduced bovine complex I in lipid nanodisc, NADH-active-DDM 提交 2025-09-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 Z 1–144（144 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 17 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 LMT DODECYL-BETA-D-MALTOSIDE × 1 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.61 Å
9SMI Reduced bovine complex I in lipid nanodisc, NADH-deactive 提交 2025-09-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 Z 1–144（144 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 27 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 LMT DODECYL-BETA-D-MALTOSIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 5 CHD CHOLIC ACID × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.01 Å
9W2U Cryo-EM structure of complex I on the bovine heart submitochondrial particles, open 提交 2025-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 Z 4–144（141 aa）	未记录	FME N-FORMYLMETHIONINE × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 18 CDL CARDIOLIPIN × 6 CHD CHOLIC ACID × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.60 Å
9W2V Cryo-EM structure of complex I on the bovine heart submitochondrial particles, closed 提交 2025-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 Z 4–144（141 aa）	未记录	FME N-FORMYLMETHIONINE × 4 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 19 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 12 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 6 MG MAGNESIUM ION × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.80 Å

共 49 个其他 PDB 条目、49 个 assembly。 打开独立比较页并筛选聚集状态

查看构建体与数据证据

UniProt名称	NDUAD_BOVIN
Isoform	—
PDB实体	26
链与序列区间	作者链 Z； PDB构建体 27–95； UniProt 32–100

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1

物种未注明

UniProt Q02377

当前结构中的状态

Assembly	聚集状态	构建体	突变与修饰	配体、离子与共同组分	实验方法与环境	结构质量
1	蛋白异源复合物 异源复合物 蛋白 × 45 PDB 声明：45-meric（45） 与蛋白拷贝数一致	链 a； UniProt 1–70	未记录	NADH-ubiquinone oxidoreductase chain 3 × 1 （P03898） NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial × 1 （P42026） NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial × 1 （P23709） NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial × 1 （P17694） NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial × 1 （P04394） NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial × 1 （P25708） ;NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, NDUFS1 ; × 1 （P15690） NADH-ubiquinone oxidoreductase chain 1 × 1 （P03887） NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial × 1 （P42028） NADH-ubiquinone oxidoreductase chain 6 × 1 （P03924） NADH-ubiquinone oxidoreductase chain 4L × 1 （P03902） NADH-ubiquinone oxidoreductase chain 5 × 1 （P03920） NADH-ubiquinone oxidoreductase chain 4 × 1 （P03910） NADH-ubiquinone oxidoreductase chain 2 × 1 （P03892） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, NDUFA10,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial ; × 1 （P34942） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial × 1 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial × 1 ;NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial ; × 1 （P23934） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 × 1 （Q02370） Acyl carrier protein, mitochondrial × 1 （P52505） Acyl carrier protein, mitochondrial × 1 （P52505） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 × 1 （P23935） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 × 1 （Q02366） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 ; × 1 （P42029） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 × 1 （Q8HXG6） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 ; × 1 （Q95KV7） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 ; × 1 （Q02371） NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial × 1 （Q02376） ;NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2 ; × 1 （Q02827） NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 × 1 （Q02379） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 × 1 （Q02378） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial × 1 （Q8HXG5） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial ; × 1 （Q02380） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 ; × 1 （Q02367） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, NDUFB2 × 1 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3, NDUFB3 × 1 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, NDUFB8 × 1 ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 ; × 1 （P48305） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 ; × 1 （Q02369） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 × 1 （Q02368） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10, NDUFB10,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10, NDUFB10 ; × 1 （Q02373） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 × 1 （O97725） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7, NDUFA7 × 1 NADH dehydrogenase [ubiquinone] flavoprotein 3, NDUFV3 × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液：pH 8 cryo-EM玻璃化条件：冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 4.35 Å

数据库中的同蛋白其他状态

以下每一行都是同一 UniProt 蛋白在另一个 PDB 条目中的 biological assembly， “相对当前条目”直接指出证据层面的不同；没有差异标签表示当前已读取字段一致。

其他 PDB	相对当前条目 5LC5	Assembly / 聚集状态	构建体	突变与修饰	配体、离子与非聚合物	实验方法与环境	结构质量
5LDW Structure of mammalian respiratory Complex I, class1 提交 2016-06-28	实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 a 1–70（70 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8；20 mM TRIS-HCL, 150 mM NaCl, 0.03% CYMAL-7 cryo-EM玻璃化条件 冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus present in a cold room, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 4.27 Å
5LDX Structure of mammalian respiratory Complex I, class3. 提交 2016-06-28	结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 a 1–70（70 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 20 mM TRIS-HCL, 150 mM NaCl, 0.03% CYMAL-7；pH 8 cryo-EM玻璃化条件 冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 5.60 Å
5O31 Mitochondrial complex I in the deactive state 提交 2017-05-23	实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 a 1–70（70 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.55 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.13 Å
7DGQ Activity optimized supercomplex state1 提交 2020-11-12	聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 J 1–70（70 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 CU COPPER (II) ION × 3 HEA HEME-A × 2 MG MAGNESIUM ION × 1 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 UQ2 UBIQUINONE-2 × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 5.00 Å
7DGR Activity optimized supercomplex state2 提交 2020-11-12	聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 J 1–70（70 aa）	未记录	FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 3 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.60 Å
7DGS Activity optimized supercomplex state3 提交 2020-11-12	聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 J 1–70（70 aa）	未记录	FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 7.80 Å
7DGZ Activity optimized complex I (closed form) 提交 2020-11-12	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 J 1–70（70 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 2 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 3.80 Å
7DH0 Activity optimized complex I (open form) 提交 2020-11-12	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 J 1–70（70 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.20 Å
7DKF Activity optimized supercomplex state4 提交 2020-11-24	聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 J2 1–70（70 aa）	未记录	HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 8.30 Å
7QSD Bovine complex I in the active state at 3.1 A 提交 2022-01-13	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 a 1–70（70 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 13 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 CDL CARDIOLIPIN × 4 LMT DODECYL-BETA-D-MALTOSIDE × 3 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 3.10 Å
7QSK Bovine complex I in lipid nanodisc, Active-Q10 提交 2022-01-13	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 a 1–70（70 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 19 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.84 Å
7QSL Bovine complex I in lipid nanodisc, Active-apo 提交 2022-01-13	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 a 1–70（70 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 20 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 8 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.76 Å
7QSM Bovine complex I in lipid nanodisc, Deactive-ligand (composite) 提交 2022-01-13	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 a 1–70（70 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 GOL GLYCEROL × 1 LMT DODECYL-BETA-D-MALTOSIDE × 1 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.30 Å
7QSN Bovine complex I in lipid nanodisc, Deactive-apo 提交 2022-01-13	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 a 1–70（70 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 6 CHD CHOLIC ACID × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.81 Å
7QSO Bovine complex I in lipid nanodisc, State 3 (Slack) 提交 2022-01-13	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 a 1–70（70 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 6 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CHD CHOLIC ACID × 2 CDL CARDIOLIPIN × 6 U10 UBIQUINONE-10 × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 3.02 Å
7R41 Bovine complex I in the presence of IM1761092, active class i (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 a 1–70（70 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 16 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R42 Bovine complex I in the presence of IM1761092, active class ii (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 a 1–70（70 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 17 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R43 Bovine complex I in the presence of IM1761092, active class iii (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 a 1–70（70 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 CDL CARDIOLIPIN × 5 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R44 Bovine complex I in the presence of IM1761092, active class iv (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 a 1–70（70 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 11 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R45 Bovine complex I in the presence of IM1761092, deactive class i (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 a 1–70（70 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R46 Bovine complex I in the presence of IM1761092, deactive class ii (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 a 1–70（70 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 11 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R47 Bovine complex I in the presence of IM1761092, deactive class iii (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 a 1–70（70 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R48 Bovine complex I in the presence of IM1761092, deactive class iv (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 a 1–70（70 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 15 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 13 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4C Bovine complex I in the presence of IM1761092, deactive class v (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 a 1–70（70 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 12 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4D Bovine complex I in the presence of IM1761092, deactive class vi (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 a 1–70（70 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4F Bovine complex I in the presence of IM1761092, slack class i (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 a 1–70（70 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 7 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 3 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 CDL CARDIOLIPIN × 6 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R4G Bovine complex I in the presence of IM1761092, slack class ii (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 a 1–70（70 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 LMT DODECYL-BETA-D-MALTOSIDE × 10 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.50 Å
8Q0A Inward-facing, closed proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 a 1–70（70 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 16 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 8 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 MG MAGNESIUM ION × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0F Inward-facing, open2 proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 a 1–70（70 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 21 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0J Inward-facing, slack proteoliposome complex I at 3.8 A. Initially purified in DDM. 提交 2023-07-28	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 a 1–70（70 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 4 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.80 Å
8Q0M Outward-facing, closed proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 a 1–70（70 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0O Outward-facing, open2 proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 a 1–70（70 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0Q Outward-facing, slack proteoliposome complex I at 3.6 A. Initially purified in DDM 提交 2023-07-28	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 a 1–70（70 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 4 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.60 Å
8Q1P Inward-facing, open2 proteoliposome complex I at 2.9 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 a 1–70（70 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.90 Å
8Q1U Inward-facing, open1 proteoliposome complex I at 3.3 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 a 1–70（70 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 15 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 5 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.30 Å
8Q1Y Outward-facing, open2 proteoliposome complex I at 2.6 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 a 1–70（70 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 ZN ZINC ION × 2 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q25 Outward-facing, open1 proteoliposome complex I at 2.8 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 a 1–70（70 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 ZN ZINC ION × 2 MG MAGNESIUM ION × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.80 Å
8Q45 Inward-facing, closed proteoliposome complex I at 2.7 A. Initially purified in LMNG. 提交 2023-08-05	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 a 1–70（70 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 16 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.70 Å
8Q46 Inward-facing, open2 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 a 1–70（70 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q47 Inward-facing, open1 proteoliposome complex I at 2.9 A. Initially purified in LMNG. 提交 2023-08-05	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 a 1–70（70 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 15 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 26 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 5 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.90 Å
8Q48 Outward-facing, closed proteoliposome complex I at 2.5 A. Initially purified in LMNG. 提交 2023-08-05	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 a 1–70（70 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 35 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.50 Å
8Q49 Outward-facing, open2 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 a 1–70（70 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CHD CHOLIC ACID × 1 ZN ZINC ION × 2 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 FVH [[(2~{R},3~{S},4~{R},5~{R})-5-[(3~{R})-3-aminocarbonylpiperidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{R},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3-oxidanyl-4-phosphonooxy-oxolan-2-yl]methyl hydrogen phosphate × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q4A Outward-facing, open1 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 a 1–70（70 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
9SMF Reduced bovine complex I in lipid nanodisc, NADH-active-Q10 提交 2025-09-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 a 1–70（70 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 20 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 8 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.51 Å
9SMG Reduced bovine complex I in lipid nanodisc, NADH-active-altQ10 提交 2025-09-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 a 1–70（70 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 18 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.42 Å
9SMH Reduced bovine complex I in lipid nanodisc, NADH-active-DDM 提交 2025-09-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 a 1–70（70 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 17 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 LMT DODECYL-BETA-D-MALTOSIDE × 1 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.61 Å
9SMI Reduced bovine complex I in lipid nanodisc, NADH-deactive 提交 2025-09-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 a 1–70（70 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 27 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 LMT DODECYL-BETA-D-MALTOSIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 5 CHD CHOLIC ACID × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.01 Å
9W2U Cryo-EM structure of complex I on the bovine heart submitochondrial particles, open 提交 2025-07-28	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 a 1–70（70 aa）	未记录	FME N-FORMYLMETHIONINE × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 18 CDL CARDIOLIPIN × 6 CHD CHOLIC ACID × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.60 Å
9W2V Cryo-EM structure of complex I on the bovine heart submitochondrial particles, closed 提交 2025-07-28	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 a 1–70（70 aa）	未记录	FME N-FORMYLMETHIONINE × 4 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 19 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 12 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 6 MG MAGNESIUM ION × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.80 Å

共 49 个其他 PDB 条目、49 个 assembly。 打开独立比较页并筛选聚集状态

查看构建体与数据证据

UniProt名称	NDUA1_BOVIN
Isoform	—
PDB实体	27
链与序列区间	作者链 a； PDB构建体 1–70； UniProt 1–70

;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 ;

物种未注明

UniProt Q02371

当前结构中的状态

Assembly	聚集状态	构建体	突变与修饰	配体、离子与共同组分	实验方法与环境	结构质量
1	蛋白异源复合物 异源复合物 蛋白 × 45 PDB 声明：45-meric（45） 与蛋白拷贝数一致	链 b； UniProt 2–46	未记录	NADH-ubiquinone oxidoreductase chain 3 × 1 （P03898） NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial × 1 （P42026） NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial × 1 （P23709） NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial × 1 （P17694） NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial × 1 （P04394） NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial × 1 （P25708） ;NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, NDUFS1 ; × 1 （P15690） NADH-ubiquinone oxidoreductase chain 1 × 1 （P03887） NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial × 1 （P42028） NADH-ubiquinone oxidoreductase chain 6 × 1 （P03924） NADH-ubiquinone oxidoreductase chain 4L × 1 （P03902） NADH-ubiquinone oxidoreductase chain 5 × 1 （P03920） NADH-ubiquinone oxidoreductase chain 4 × 1 （P03910） NADH-ubiquinone oxidoreductase chain 2 × 1 （P03892） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, NDUFA10,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial ; × 1 （P34942） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial × 1 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial × 1 ;NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial ; × 1 （P23934） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 × 1 （Q02370） Acyl carrier protein, mitochondrial × 1 （P52505） Acyl carrier protein, mitochondrial × 1 （P52505） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 × 1 （P23935） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 × 1 （Q02366） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 ; × 1 （P42029） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 × 1 （Q8HXG6） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 ; × 1 （Q95KV7） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 × 1 （Q02377） NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial × 1 （Q02376） ;NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2 ; × 1 （Q02827） NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 × 1 （Q02379） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 × 1 （Q02378） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial × 1 （Q8HXG5） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial ; × 1 （Q02380） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 ; × 1 （Q02367） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, NDUFB2 × 1 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3, NDUFB3 × 1 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, NDUFB8 × 1 ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 ; × 1 （P48305） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 ; × 1 （Q02369） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 × 1 （Q02368） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10, NDUFB10,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10, NDUFB10 ; × 1 （Q02373） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 × 1 （O97725） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7, NDUFA7 × 1 NADH dehydrogenase [ubiquinone] flavoprotein 3, NDUFV3 × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液：pH 8 cryo-EM玻璃化条件：冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 4.35 Å

数据库中的同蛋白其他状态

以下每一行都是同一 UniProt 蛋白在另一个 PDB 条目中的 biological assembly， “相对当前条目”直接指出证据层面的不同；没有差异标签表示当前已读取字段一致。

其他 PDB	相对当前条目 5LC5	Assembly / 聚集状态	构建体	突变与修饰	配体、离子与非聚合物	实验方法与环境	结构质量
5LDW Structure of mammalian respiratory Complex I, class1 提交 2016-06-28	实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 b 2–46（45 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8；20 mM TRIS-HCL, 150 mM NaCl, 0.03% CYMAL-7 cryo-EM玻璃化条件 冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus present in a cold room, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 4.27 Å
5LDX Structure of mammalian respiratory Complex I, class3. 提交 2016-06-28	结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 b 2–46（45 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 20 mM TRIS-HCL, 150 mM NaCl, 0.03% CYMAL-7；pH 8 cryo-EM玻璃化条件 冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 5.60 Å
5O31 Mitochondrial complex I in the deactive state 提交 2017-05-23	实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 b 2–46（45 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.55 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.13 Å
7DGQ Activity optimized supercomplex state1 提交 2020-11-12	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 L 2–84（83 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 CU COPPER (II) ION × 3 HEA HEME-A × 2 MG MAGNESIUM ION × 1 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 UQ2 UBIQUINONE-2 × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 5.00 Å
7DGR Activity optimized supercomplex state2 提交 2020-11-12	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 L 2–84（83 aa）	未记录	FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 3 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.60 Å
7DGS Activity optimized supercomplex state3 提交 2020-11-12	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 L 2–84（83 aa）	未记录	FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 7.80 Å
7DGZ Activity optimized complex I (closed form) 提交 2020-11-12	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 L 2–84（83 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 2 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 3.80 Å
7DH0 Activity optimized complex I (open form) 提交 2020-11-12	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 L 2–84（83 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.20 Å
7DKF Activity optimized supercomplex state4 提交 2020-11-24	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 L2 2–84（83 aa）	未记录	HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 8.30 Å
7QSD Bovine complex I in the active state at 3.1 A 提交 2022-01-13	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 b 1–84（84 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 13 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 CDL CARDIOLIPIN × 4 LMT DODECYL-BETA-D-MALTOSIDE × 3 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 3.10 Å
7QSK Bovine complex I in lipid nanodisc, Active-Q10 提交 2022-01-13	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 b 1–84（84 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 19 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.84 Å
7QSL Bovine complex I in lipid nanodisc, Active-apo 提交 2022-01-13	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 b 1–84（84 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 20 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 8 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.76 Å
7QSM Bovine complex I in lipid nanodisc, Deactive-ligand (composite) 提交 2022-01-13	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 b 1–84（84 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 GOL GLYCEROL × 1 LMT DODECYL-BETA-D-MALTOSIDE × 1 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.30 Å
7QSN Bovine complex I in lipid nanodisc, Deactive-apo 提交 2022-01-13	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 b 1–84（84 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 6 CHD CHOLIC ACID × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.81 Å
7QSO Bovine complex I in lipid nanodisc, State 3 (Slack) 提交 2022-01-13	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 b 1–84（84 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 6 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CHD CHOLIC ACID × 2 CDL CARDIOLIPIN × 6 U10 UBIQUINONE-10 × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 3.02 Å
7R41 Bovine complex I in the presence of IM1761092, active class i (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 b 1–84（84 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 16 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R42 Bovine complex I in the presence of IM1761092, active class ii (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 b 1–84（84 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 17 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R43 Bovine complex I in the presence of IM1761092, active class iii (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 b 1–84（84 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 CDL CARDIOLIPIN × 5 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R44 Bovine complex I in the presence of IM1761092, active class iv (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 b 1–84（84 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 11 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R45 Bovine complex I in the presence of IM1761092, deactive class i (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 b 1–84（84 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R46 Bovine complex I in the presence of IM1761092, deactive class ii (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 b 1–84（84 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 11 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R47 Bovine complex I in the presence of IM1761092, deactive class iii (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 b 1–84（84 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R48 Bovine complex I in the presence of IM1761092, deactive class iv (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 b 1–84（84 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 15 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 13 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4C Bovine complex I in the presence of IM1761092, deactive class v (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 b 1–84（84 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 12 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4D Bovine complex I in the presence of IM1761092, deactive class vi (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 b 1–84（84 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4F Bovine complex I in the presence of IM1761092, slack class i (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 b 1–84（84 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 7 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 3 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 CDL CARDIOLIPIN × 6 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R4G Bovine complex I in the presence of IM1761092, slack class ii (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 b 1–84（84 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 LMT DODECYL-BETA-D-MALTOSIDE × 10 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.50 Å
8Q0A Inward-facing, closed proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 b 1–84（84 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 16 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 8 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 MG MAGNESIUM ION × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0F Inward-facing, open2 proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 b 1–84（84 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 21 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0J Inward-facing, slack proteoliposome complex I at 3.8 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 b 1–84（84 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 4 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.80 Å
8Q0M Outward-facing, closed proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 b 1–84（84 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0O Outward-facing, open2 proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 b 1–84（84 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0Q Outward-facing, slack proteoliposome complex I at 3.6 A. Initially purified in DDM 提交 2023-07-28	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 b 1–84（84 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 4 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.60 Å
8Q1P Inward-facing, open2 proteoliposome complex I at 2.9 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 b 1–84（84 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.90 Å
8Q1U Inward-facing, open1 proteoliposome complex I at 3.3 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 b 1–84（84 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 15 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 5 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.30 Å
8Q1Y Outward-facing, open2 proteoliposome complex I at 2.6 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 b 1–84（84 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 ZN ZINC ION × 2 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q25 Outward-facing, open1 proteoliposome complex I at 2.8 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 b 1–84（84 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 ZN ZINC ION × 2 MG MAGNESIUM ION × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.80 Å
8Q45 Inward-facing, closed proteoliposome complex I at 2.7 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 b 1–84（84 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 16 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.70 Å
8Q46 Inward-facing, open2 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 b 1–84（84 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q47 Inward-facing, open1 proteoliposome complex I at 2.9 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 b 1–84（84 aa）	非标准单体：是（mmCIF未提供具体位点）	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 15 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 26 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 5 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.90 Å
8Q48 Outward-facing, closed proteoliposome complex I at 2.5 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 b 1–84（84 aa）	非标准单体：是（mmCIF未提供具体位点）	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 35 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.50 Å
8Q49 Outward-facing, open2 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 b 1–84（84 aa）	非标准单体：是（mmCIF未提供具体位点）	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CHD CHOLIC ACID × 1 ZN ZINC ION × 2 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 FVH [[(2~{R},3~{S},4~{R},5~{R})-5-[(3~{R})-3-aminocarbonylpiperidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{R},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3-oxidanyl-4-phosphonooxy-oxolan-2-yl]methyl hydrogen phosphate × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q4A Outward-facing, open1 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 b 1–84（84 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
9SMF Reduced bovine complex I in lipid nanodisc, NADH-active-Q10 提交 2025-09-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 b 1–84（84 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 20 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 8 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.51 Å
9SMG Reduced bovine complex I in lipid nanodisc, NADH-active-altQ10 提交 2025-09-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 b 1–84（84 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 18 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.42 Å
9SMH Reduced bovine complex I in lipid nanodisc, NADH-active-DDM 提交 2025-09-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 b 1–84（84 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 17 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 LMT DODECYL-BETA-D-MALTOSIDE × 1 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.61 Å
9SMI Reduced bovine complex I in lipid nanodisc, NADH-deactive 提交 2025-09-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 b 1–84（84 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 27 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 LMT DODECYL-BETA-D-MALTOSIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 5 CHD CHOLIC ACID × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.01 Å
9W2U Cryo-EM structure of complex I on the bovine heart submitochondrial particles, open 提交 2025-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 b 2–84（83 aa）	未记录	FME N-FORMYLMETHIONINE × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 18 CDL CARDIOLIPIN × 6 CHD CHOLIC ACID × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.60 Å
9W2V Cryo-EM structure of complex I on the bovine heart submitochondrial particles, closed 提交 2025-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 b 2–84（83 aa）	未记录	FME N-FORMYLMETHIONINE × 4 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 19 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 12 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 6 MG MAGNESIUM ION × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.80 Å

共 49 个其他 PDB 条目、49 个 assembly。 打开独立比较页并筛选聚集状态

查看构建体与数据证据

UniProt名称	NDUA3_BOVIN
Isoform	—
PDB实体	28
链与序列区间	作者链 b； PDB构建体 1–45； UniProt 2–46

NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial

物种未注明

UniProt Q02376

当前结构中的状态

Assembly	聚集状态	构建体	突变与修饰	配体、离子与共同组分	实验方法与环境	结构质量
1	蛋白异源复合物 异源复合物 蛋白 × 45 PDB 声明：45-meric（45） 与蛋白拷贝数一致	链 c； UniProt 1–76	未记录	NADH-ubiquinone oxidoreductase chain 3 × 1 （P03898） NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial × 1 （P42026） NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial × 1 （P23709） NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial × 1 （P17694） NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial × 1 （P04394） NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial × 1 （P25708） ;NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, NDUFS1 ; × 1 （P15690） NADH-ubiquinone oxidoreductase chain 1 × 1 （P03887） NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial × 1 （P42028） NADH-ubiquinone oxidoreductase chain 6 × 1 （P03924） NADH-ubiquinone oxidoreductase chain 4L × 1 （P03902） NADH-ubiquinone oxidoreductase chain 5 × 1 （P03920） NADH-ubiquinone oxidoreductase chain 4 × 1 （P03910） NADH-ubiquinone oxidoreductase chain 2 × 1 （P03892） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, NDUFA10,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial ; × 1 （P34942） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial × 1 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial × 1 ;NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial ; × 1 （P23934） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 × 1 （Q02370） Acyl carrier protein, mitochondrial × 1 （P52505） Acyl carrier protein, mitochondrial × 1 （P52505） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 × 1 （P23935） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 × 1 （Q02366） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 ; × 1 （P42029） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 × 1 （Q8HXG6） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 ; × 1 （Q95KV7） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 × 1 （Q02377） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 ; × 1 （Q02371） ;NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2 ; × 1 （Q02827） NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 × 1 （Q02379） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 × 1 （Q02378） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial × 1 （Q8HXG5） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial ; × 1 （Q02380） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 ; × 1 （Q02367） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, NDUFB2 × 1 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3, NDUFB3 × 1 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, NDUFB8 × 1 ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 ; × 1 （P48305） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 ; × 1 （Q02369） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 × 1 （Q02368） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10, NDUFB10,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10, NDUFB10 ; × 1 （Q02373） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 × 1 （O97725） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7, NDUFA7 × 1 NADH dehydrogenase [ubiquinone] flavoprotein 3, NDUFV3 × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液：pH 8 cryo-EM玻璃化条件：冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 4.35 Å

数据库中的同蛋白其他状态

以下每一行都是同一 UniProt 蛋白在另一个 PDB 条目中的 biological assembly， “相对当前条目”直接指出证据层面的不同；没有差异标签表示当前已读取字段一致。

其他 PDB	相对当前条目 5LC5	Assembly / 聚集状态	构建体	突变与修饰	配体、离子与非聚合物	实验方法与环境	结构质量
5LDW Structure of mammalian respiratory Complex I, class1 提交 2016-06-28	构建体不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 c 28–76（49 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8；20 mM TRIS-HCL, 150 mM NaCl, 0.03% CYMAL-7 cryo-EM玻璃化条件 冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus present in a cold room, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 4.27 Å
5LDX Structure of mammalian respiratory Complex I, class3. 提交 2016-06-28	构建体不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 c 28–76（49 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 20 mM TRIS-HCL, 150 mM NaCl, 0.03% CYMAL-7；pH 8 cryo-EM玻璃化条件 冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 5.60 Å
5O31 Mitochondrial complex I in the deactive state 提交 2017-05-23	构建体不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 c 28–76（49 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.55 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.13 Å
7DGQ Activity optimized supercomplex state1 提交 2020-11-12	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 i 28–76（49 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 CU COPPER (II) ION × 3 HEA HEME-A × 2 MG MAGNESIUM ION × 1 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 UQ2 UBIQUINONE-2 × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 5.00 Å
7DGR Activity optimized supercomplex state2 提交 2020-11-12	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 i 28–76（49 aa）	未记录	FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 3 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.60 Å
7DGS Activity optimized supercomplex state3 提交 2020-11-12	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 i 28–76（49 aa）	未记录	FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 7.80 Å
7DGZ Activity optimized complex I (closed form) 提交 2020-11-12	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 i 28–76（49 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 2 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 3.80 Å
7DH0 Activity optimized complex I (open form) 提交 2020-11-12	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 i 28–76（49 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.20 Å
7DKF Activity optimized supercomplex state4 提交 2020-11-24	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 i2 28–76（49 aa）	未记录	HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 8.30 Å
7QSD Bovine complex I in the active state at 3.1 A 提交 2022-01-13	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 c 1–76（76 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 13 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 CDL CARDIOLIPIN × 4 LMT DODECYL-BETA-D-MALTOSIDE × 3 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 3.10 Å
7QSK Bovine complex I in lipid nanodisc, Active-Q10 提交 2022-01-13	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 c 1–76（76 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 19 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.84 Å
7QSL Bovine complex I in lipid nanodisc, Active-apo 提交 2022-01-13	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 c 1–76（76 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 20 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 8 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.76 Å
7QSM Bovine complex I in lipid nanodisc, Deactive-ligand (composite) 提交 2022-01-13	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 c 1–76（76 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 GOL GLYCEROL × 1 LMT DODECYL-BETA-D-MALTOSIDE × 1 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.30 Å
7QSN Bovine complex I in lipid nanodisc, Deactive-apo 提交 2022-01-13	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 c 1–76（76 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 6 CHD CHOLIC ACID × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.81 Å
7QSO Bovine complex I in lipid nanodisc, State 3 (Slack) 提交 2022-01-13	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 c 1–76（76 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 6 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CHD CHOLIC ACID × 2 CDL CARDIOLIPIN × 6 U10 UBIQUINONE-10 × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 3.02 Å
7R41 Bovine complex I in the presence of IM1761092, active class i (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 c 1–76（76 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 16 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R42 Bovine complex I in the presence of IM1761092, active class ii (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 c 1–76（76 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 17 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R43 Bovine complex I in the presence of IM1761092, active class iii (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 c 1–76（76 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 CDL CARDIOLIPIN × 5 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R44 Bovine complex I in the presence of IM1761092, active class iv (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 c 1–76（76 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 11 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R45 Bovine complex I in the presence of IM1761092, deactive class i (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 c 1–76（76 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R46 Bovine complex I in the presence of IM1761092, deactive class ii (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 c 1–76（76 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 11 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R47 Bovine complex I in the presence of IM1761092, deactive class iii (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 c 1–76（76 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R48 Bovine complex I in the presence of IM1761092, deactive class iv (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 c 1–76（76 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 15 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 13 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4C Bovine complex I in the presence of IM1761092, deactive class v (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 c 1–76（76 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 12 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4D Bovine complex I in the presence of IM1761092, deactive class vi (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 c 1–76（76 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4F Bovine complex I in the presence of IM1761092, slack class i (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 c 1–76（76 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 7 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 3 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 CDL CARDIOLIPIN × 6 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R4G Bovine complex I in the presence of IM1761092, slack class ii (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 c 1–76（76 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 LMT DODECYL-BETA-D-MALTOSIDE × 10 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.50 Å
8Q0A Inward-facing, closed proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 c 1–76（76 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 16 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 8 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 MG MAGNESIUM ION × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0F Inward-facing, open2 proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 c 1–76（76 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 21 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0J Inward-facing, slack proteoliposome complex I at 3.8 A. Initially purified in DDM. 提交 2023-07-28	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 c 1–76（76 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 4 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.80 Å
8Q0M Outward-facing, closed proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 c 1–76（76 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0O Outward-facing, open2 proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 c 1–76（76 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0Q Outward-facing, slack proteoliposome complex I at 3.6 A. Initially purified in DDM 提交 2023-07-28	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 c 1–76（76 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 4 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.60 Å
8Q1P Inward-facing, open2 proteoliposome complex I at 2.9 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 c 1–76（76 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.90 Å
8Q1U Inward-facing, open1 proteoliposome complex I at 3.3 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 c 1–76（76 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 15 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 5 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.30 Å
8Q1Y Outward-facing, open2 proteoliposome complex I at 2.6 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 c 1–76（76 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 ZN ZINC ION × 2 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q25 Outward-facing, open1 proteoliposome complex I at 2.8 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 c 1–76（76 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 ZN ZINC ION × 2 MG MAGNESIUM ION × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.80 Å
8Q45 Inward-facing, closed proteoliposome complex I at 2.7 A. Initially purified in LMNG. 提交 2023-08-05	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 c 1–76（76 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 16 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.70 Å
8Q46 Inward-facing, open2 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 c 1–76（76 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q47 Inward-facing, open1 proteoliposome complex I at 2.9 A. Initially purified in LMNG. 提交 2023-08-05	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 c 1–76（76 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 15 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 26 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 5 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.90 Å
8Q48 Outward-facing, closed proteoliposome complex I at 2.5 A. Initially purified in LMNG. 提交 2023-08-05	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 c 1–76（76 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 35 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.50 Å
8Q49 Outward-facing, open2 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 c 1–76（76 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CHD CHOLIC ACID × 1 ZN ZINC ION × 2 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 FVH [[(2~{R},3~{S},4~{R},5~{R})-5-[(3~{R})-3-aminocarbonylpiperidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{R},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3-oxidanyl-4-phosphonooxy-oxolan-2-yl]methyl hydrogen phosphate × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q4A Outward-facing, open1 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 c 1–76（76 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
9SMF Reduced bovine complex I in lipid nanodisc, NADH-active-Q10 提交 2025-09-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 c 1–76（76 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 20 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 8 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.51 Å
9SMG Reduced bovine complex I in lipid nanodisc, NADH-active-altQ10 提交 2025-09-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 c 1–76（76 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 18 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.42 Å
9SMH Reduced bovine complex I in lipid nanodisc, NADH-active-DDM 提交 2025-09-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 c 1–76（76 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 17 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 LMT DODECYL-BETA-D-MALTOSIDE × 1 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.61 Å
9SMI Reduced bovine complex I in lipid nanodisc, NADH-deactive 提交 2025-09-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 c 1–76（76 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 27 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 LMT DODECYL-BETA-D-MALTOSIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 5 CHD CHOLIC ACID × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.01 Å
9W2U Cryo-EM structure of complex I on the bovine heart submitochondrial particles, open 提交 2025-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 c 28–76（49 aa）	未记录	FME N-FORMYLMETHIONINE × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 18 CDL CARDIOLIPIN × 6 CHD CHOLIC ACID × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.60 Å
9W2V Cryo-EM structure of complex I on the bovine heart submitochondrial particles, closed 提交 2025-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 c 28–76（49 aa）	未记录	FME N-FORMYLMETHIONINE × 4 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 19 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 12 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 6 MG MAGNESIUM ION × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.80 Å

共 49 个其他 PDB 条目、49 个 assembly。 打开独立比较页并筛选聚集状态

查看构建体与数据证据

UniProt名称	NDUC1_BOVIN
Isoform	—
PDB实体	29
链与序列区间	作者链 c； PDB构建体 1–76； UniProt 1–76

;NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2 ;

物种未注明

UniProt Q02827

当前结构中的状态

Assembly	聚集状态	构建体	突变与修饰	配体、离子与共同组分	实验方法与环境	结构质量
1	蛋白异源复合物 异源复合物 蛋白 × 45 PDB 声明：45-meric（45） 与蛋白拷贝数一致	链 d； UniProt 29–97	未记录	NADH-ubiquinone oxidoreductase chain 3 × 1 （P03898） NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial × 1 （P42026） NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial × 1 （P23709） NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial × 1 （P17694） NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial × 1 （P04394） NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial × 1 （P25708） ;NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, NDUFS1 ; × 1 （P15690） NADH-ubiquinone oxidoreductase chain 1 × 1 （P03887） NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial × 1 （P42028） NADH-ubiquinone oxidoreductase chain 6 × 1 （P03924） NADH-ubiquinone oxidoreductase chain 4L × 1 （P03902） NADH-ubiquinone oxidoreductase chain 5 × 1 （P03920） NADH-ubiquinone oxidoreductase chain 4 × 1 （P03910） NADH-ubiquinone oxidoreductase chain 2 × 1 （P03892） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, NDUFA10,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial ; × 1 （P34942） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial × 1 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial × 1 ;NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial ; × 1 （P23934） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 × 1 （Q02370） Acyl carrier protein, mitochondrial × 1 （P52505） Acyl carrier protein, mitochondrial × 1 （P52505） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 × 1 （P23935） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 × 1 （Q02366） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 ; × 1 （P42029） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 × 1 （Q8HXG6） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 ; × 1 （Q95KV7） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 × 1 （Q02377） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 ; × 1 （Q02371） NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial × 1 （Q02376） NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 × 1 （Q02379） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 × 1 （Q02378） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial × 1 （Q8HXG5） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial ; × 1 （Q02380） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 ; × 1 （Q02367） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, NDUFB2 × 1 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3, NDUFB3 × 1 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, NDUFB8 × 1 ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 ; × 1 （P48305） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 ; × 1 （Q02369） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 × 1 （Q02368） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10, NDUFB10,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10, NDUFB10 ; × 1 （Q02373） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 × 1 （O97725） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7, NDUFA7 × 1 NADH dehydrogenase [ubiquinone] flavoprotein 3, NDUFV3 × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液：pH 8 cryo-EM玻璃化条件：冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 4.35 Å

数据库中的同蛋白其他状态

以下每一行都是同一 UniProt 蛋白在另一个 PDB 条目中的 biological assembly， “相对当前条目”直接指出证据层面的不同；没有差异标签表示当前已读取字段一致。

其他 PDB	相对当前条目 5LC5	Assembly / 聚集状态	构建体	突变与修饰	配体、离子与非聚合物	实验方法与环境	结构质量
5LDW Structure of mammalian respiratory Complex I, class1 提交 2016-06-28	构建体不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 d 29–96（68 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8；20 mM TRIS-HCL, 150 mM NaCl, 0.03% CYMAL-7 cryo-EM玻璃化条件 冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus present in a cold room, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 4.27 Å
5LDX Structure of mammalian respiratory Complex I, class3. 提交 2016-06-28	结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 d 29–97（69 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 20 mM TRIS-HCL, 150 mM NaCl, 0.03% CYMAL-7；pH 8 cryo-EM玻璃化条件 冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 5.60 Å
5O31 Mitochondrial complex I in the deactive state 提交 2017-05-23	构建体不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 d 1–97（97 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.55 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.13 Å
7DGQ Activity optimized supercomplex state1 提交 2020-11-12	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 j 1–120（120 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 CU COPPER (II) ION × 3 HEA HEME-A × 2 MG MAGNESIUM ION × 1 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 UQ2 UBIQUINONE-2 × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 5.00 Å
7DGR Activity optimized supercomplex state2 提交 2020-11-12	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 j 1–120（120 aa）	未记录	FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 3 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.60 Å
7DGS Activity optimized supercomplex state3 提交 2020-11-12	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 j 1–120（120 aa）	未记录	FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 7.80 Å
7DGZ Activity optimized complex I (closed form) 提交 2020-11-12	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 j 1–120（120 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 2 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 3.80 Å
7DH0 Activity optimized complex I (open form) 提交 2020-11-12	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 j 1–120（120 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.20 Å
7DKF Activity optimized supercomplex state4 提交 2020-11-24	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 j2 1–120（120 aa）	未记录	HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 8.30 Å
7QSD Bovine complex I in the active state at 3.1 A 提交 2022-01-13	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 d 1–120（120 aa）	非标准单体：是（mmCIF未提供具体位点）	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 13 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 CDL CARDIOLIPIN × 4 LMT DODECYL-BETA-D-MALTOSIDE × 3 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 3.10 Å
7QSK Bovine complex I in lipid nanodisc, Active-Q10 提交 2022-01-13	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 d 1–120（120 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 19 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.84 Å
7QSL Bovine complex I in lipid nanodisc, Active-apo 提交 2022-01-13	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 d 1–120（120 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 20 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 8 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.76 Å
7QSM Bovine complex I in lipid nanodisc, Deactive-ligand (composite) 提交 2022-01-13	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 d 1–120（120 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 GOL GLYCEROL × 1 LMT DODECYL-BETA-D-MALTOSIDE × 1 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.30 Å
7QSN Bovine complex I in lipid nanodisc, Deactive-apo 提交 2022-01-13	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 d 1–120（120 aa）	非标准单体：是（mmCIF未提供具体位点）	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 6 CHD CHOLIC ACID × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.81 Å
7QSO Bovine complex I in lipid nanodisc, State 3 (Slack) 提交 2022-01-13	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 d 1–120（120 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 6 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CHD CHOLIC ACID × 2 CDL CARDIOLIPIN × 6 U10 UBIQUINONE-10 × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 3.02 Å
7R41 Bovine complex I in the presence of IM1761092, active class i (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 d 1–120（120 aa）	非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 16 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R42 Bovine complex I in the presence of IM1761092, active class ii (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 d 1–120（120 aa）	非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 17 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R43 Bovine complex I in the presence of IM1761092, active class iii (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 d 1–120（120 aa）	非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 CDL CARDIOLIPIN × 5 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R44 Bovine complex I in the presence of IM1761092, active class iv (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 d 1–120（120 aa）	非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 11 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R45 Bovine complex I in the presence of IM1761092, deactive class i (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 d 1–120（120 aa）	非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R46 Bovine complex I in the presence of IM1761092, deactive class ii (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 d 1–120（120 aa）	非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 11 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R47 Bovine complex I in the presence of IM1761092, deactive class iii (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 d 1–120（120 aa）	非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R48 Bovine complex I in the presence of IM1761092, deactive class iv (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 d 1–120（120 aa）	非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 15 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 13 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4C Bovine complex I in the presence of IM1761092, deactive class v (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 d 1–120（120 aa）	非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 12 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4D Bovine complex I in the presence of IM1761092, deactive class vi (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 d 1–120（120 aa）	非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4F Bovine complex I in the presence of IM1761092, slack class i (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 d 1–120（120 aa）	非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 7 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 3 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 CDL CARDIOLIPIN × 6 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R4G Bovine complex I in the presence of IM1761092, slack class ii (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 d 1–120（120 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 LMT DODECYL-BETA-D-MALTOSIDE × 10 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.50 Å
8Q0A Inward-facing, closed proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 d 1–120（120 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 16 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 8 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 MG MAGNESIUM ION × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0F Inward-facing, open2 proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 d 1–120（120 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 21 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0J Inward-facing, slack proteoliposome complex I at 3.8 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 d 1–120（120 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 4 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.80 Å
8Q0M Outward-facing, closed proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 d 1–120（120 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0O Outward-facing, open2 proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 d 1–120（120 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0Q Outward-facing, slack proteoliposome complex I at 3.6 A. Initially purified in DDM 提交 2023-07-28	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 d 1–120（120 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 4 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.60 Å
8Q1P Inward-facing, open2 proteoliposome complex I at 2.9 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 d 1–120（120 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.90 Å
8Q1U Inward-facing, open1 proteoliposome complex I at 3.3 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 d 1–120（120 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 15 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 5 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.30 Å
8Q1Y Outward-facing, open2 proteoliposome complex I at 2.6 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 d 1–120（120 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 ZN ZINC ION × 2 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q25 Outward-facing, open1 proteoliposome complex I at 2.8 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 d 1–120（120 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 ZN ZINC ION × 2 MG MAGNESIUM ION × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.80 Å
8Q45 Inward-facing, closed proteoliposome complex I at 2.7 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 d 1–120（120 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 16 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.70 Å
8Q46 Inward-facing, open2 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 d 1–120（120 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q47 Inward-facing, open1 proteoliposome complex I at 2.9 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 d 1–120（120 aa）	非标准单体：是（mmCIF未提供具体位点）	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 15 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 26 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 5 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.90 Å
8Q48 Outward-facing, closed proteoliposome complex I at 2.5 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 d 1–120（120 aa）	非标准单体：是（mmCIF未提供具体位点）	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 35 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.50 Å
8Q49 Outward-facing, open2 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 d 1–120（120 aa）	非标准单体：是（mmCIF未提供具体位点）	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CHD CHOLIC ACID × 1 ZN ZINC ION × 2 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 FVH [[(2~{R},3~{S},4~{R},5~{R})-5-[(3~{R})-3-aminocarbonylpiperidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{R},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3-oxidanyl-4-phosphonooxy-oxolan-2-yl]methyl hydrogen phosphate × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q4A Outward-facing, open1 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 d 1–120（120 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
9SMF Reduced bovine complex I in lipid nanodisc, NADH-active-Q10 提交 2025-09-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 d 1–120（120 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 20 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 8 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.51 Å
9SMG Reduced bovine complex I in lipid nanodisc, NADH-active-altQ10 提交 2025-09-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 d 1–120（120 aa）	非标准单体：是（mmCIF未提供具体位点）	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 18 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.42 Å
9SMH Reduced bovine complex I in lipid nanodisc, NADH-active-DDM 提交 2025-09-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 d 1–120（120 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 17 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 LMT DODECYL-BETA-D-MALTOSIDE × 1 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.61 Å
9SMI Reduced bovine complex I in lipid nanodisc, NADH-deactive 提交 2025-09-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 d 1–120（120 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 27 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 LMT DODECYL-BETA-D-MALTOSIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 5 CHD CHOLIC ACID × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.01 Å
9W2U Cryo-EM structure of complex I on the bovine heart submitochondrial particles, open 提交 2025-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 d 2–120（119 aa）	未记录	FME N-FORMYLMETHIONINE × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 18 CDL CARDIOLIPIN × 6 CHD CHOLIC ACID × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.60 Å
9W2V Cryo-EM structure of complex I on the bovine heart submitochondrial particles, closed 提交 2025-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 d 2–120（119 aa）	未记录	FME N-FORMYLMETHIONINE × 4 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 19 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 12 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 6 MG MAGNESIUM ION × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.80 Å

共 49 个其他 PDB 条目、49 个 assembly。 打开独立比较页并筛选聚集状态

查看构建体与数据证据

UniProt名称	NDUC2_BOVIN
Isoform	—
PDB实体	30
链与序列区间	作者链 d； PDB构建体 27–95； UniProt 29–97

NADH dehydrogenase [ubiquinone] iron-sulfur protein 5

物种未注明

UniProt Q02379

当前结构中的状态

Assembly	聚集状态	构建体	突变与修饰	配体、离子与共同组分	实验方法与环境	结构质量
1	蛋白异源复合物 异源复合物 蛋白 × 45 PDB 声明：45-meric（45） 与蛋白拷贝数一致	链 e； UniProt 1–106	未记录	NADH-ubiquinone oxidoreductase chain 3 × 1 （P03898） NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial × 1 （P42026） NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial × 1 （P23709） NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial × 1 （P17694） NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial × 1 （P04394） NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial × 1 （P25708） ;NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, NDUFS1 ; × 1 （P15690） NADH-ubiquinone oxidoreductase chain 1 × 1 （P03887） NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial × 1 （P42028） NADH-ubiquinone oxidoreductase chain 6 × 1 （P03924） NADH-ubiquinone oxidoreductase chain 4L × 1 （P03902） NADH-ubiquinone oxidoreductase chain 5 × 1 （P03920） NADH-ubiquinone oxidoreductase chain 4 × 1 （P03910） NADH-ubiquinone oxidoreductase chain 2 × 1 （P03892） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, NDUFA10,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial ; × 1 （P34942） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial × 1 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial × 1 ;NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial ; × 1 （P23934） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 × 1 （Q02370） Acyl carrier protein, mitochondrial × 1 （P52505） Acyl carrier protein, mitochondrial × 1 （P52505） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 × 1 （P23935） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 × 1 （Q02366） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 ; × 1 （P42029） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 × 1 （Q8HXG6） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 ; × 1 （Q95KV7） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 × 1 （Q02377） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 ; × 1 （Q02371） NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial × 1 （Q02376） ;NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2 ; × 1 （Q02827） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 × 1 （Q02378） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial × 1 （Q8HXG5） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial ; × 1 （Q02380） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 ; × 1 （Q02367） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, NDUFB2 × 1 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3, NDUFB3 × 1 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, NDUFB8 × 1 ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 ; × 1 （P48305） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 ; × 1 （Q02369） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 × 1 （Q02368） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10, NDUFB10,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10, NDUFB10 ; × 1 （Q02373） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 × 1 （O97725） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7, NDUFA7 × 1 NADH dehydrogenase [ubiquinone] flavoprotein 3, NDUFV3 × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液：pH 8 cryo-EM玻璃化条件：冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 4.35 Å

数据库中的同蛋白其他状态

以下每一行都是同一 UniProt 蛋白在另一个 PDB 条目中的 biological assembly， “相对当前条目”直接指出证据层面的不同；没有差异标签表示当前已读取字段一致。

其他 PDB	相对当前条目 5LC5	Assembly / 聚集状态	构建体	突变与修饰	配体、离子与非聚合物	实验方法与环境	结构质量
5LDW Structure of mammalian respiratory Complex I, class1 提交 2016-06-28	构建体不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 e 2–106（105 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8；20 mM TRIS-HCL, 150 mM NaCl, 0.03% CYMAL-7 cryo-EM玻璃化条件 冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus present in a cold room, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 4.27 Å
5LDX Structure of mammalian respiratory Complex I, class3. 提交 2016-06-28	结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 e 1–106（106 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 20 mM TRIS-HCL, 150 mM NaCl, 0.03% CYMAL-7；pH 8 cryo-EM玻璃化条件 冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 5.60 Å
5O31 Mitochondrial complex I in the deactive state 提交 2017-05-23	构建体不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 e 2–106（105 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.55 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.13 Å
7DGQ Activity optimized supercomplex state1 提交 2020-11-12	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 H 2–106（105 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 CU COPPER (II) ION × 3 HEA HEME-A × 2 MG MAGNESIUM ION × 1 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 UQ2 UBIQUINONE-2 × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 5.00 Å
7DGR Activity optimized supercomplex state2 提交 2020-11-12	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 H 2–106（105 aa）	未记录	FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 3 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.60 Å
7DGS Activity optimized supercomplex state3 提交 2020-11-12	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 H 2–106（105 aa）	未记录	FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 7.80 Å
7DGZ Activity optimized complex I (closed form) 提交 2020-11-12	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 H 2–106（105 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 2 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 3.80 Å
7DH0 Activity optimized complex I (open form) 提交 2020-11-12	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 H 2–106（105 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.20 Å
7DKF Activity optimized supercomplex state4 提交 2020-11-24	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 H2 2–106（105 aa）	未记录	HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 8.30 Å
7QSD Bovine complex I in the active state at 3.1 A 提交 2022-01-13	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 e 1–106（106 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 13 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 CDL CARDIOLIPIN × 4 LMT DODECYL-BETA-D-MALTOSIDE × 3 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 3.10 Å
7QSK Bovine complex I in lipid nanodisc, Active-Q10 提交 2022-01-13	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 e 1–106（106 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 19 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.84 Å
7QSL Bovine complex I in lipid nanodisc, Active-apo 提交 2022-01-13	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 e 1–106（106 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 20 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 8 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.76 Å
7QSM Bovine complex I in lipid nanodisc, Deactive-ligand (composite) 提交 2022-01-13	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 e 1–106（106 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 GOL GLYCEROL × 1 LMT DODECYL-BETA-D-MALTOSIDE × 1 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.30 Å
7QSN Bovine complex I in lipid nanodisc, Deactive-apo 提交 2022-01-13	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 e 1–106（106 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 6 CHD CHOLIC ACID × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.81 Å
7QSO Bovine complex I in lipid nanodisc, State 3 (Slack) 提交 2022-01-13	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 e 1–106（106 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 6 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CHD CHOLIC ACID × 2 CDL CARDIOLIPIN × 6 U10 UBIQUINONE-10 × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 3.02 Å
7R41 Bovine complex I in the presence of IM1761092, active class i (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 e 1–106（106 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 16 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R42 Bovine complex I in the presence of IM1761092, active class ii (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 e 1–106（106 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 17 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R43 Bovine complex I in the presence of IM1761092, active class iii (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 e 1–106（106 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 CDL CARDIOLIPIN × 5 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R44 Bovine complex I in the presence of IM1761092, active class iv (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 e 1–106（106 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 11 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R45 Bovine complex I in the presence of IM1761092, deactive class i (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 e 1–106（106 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R46 Bovine complex I in the presence of IM1761092, deactive class ii (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 e 1–106（106 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 11 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R47 Bovine complex I in the presence of IM1761092, deactive class iii (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 e 1–106（106 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R48 Bovine complex I in the presence of IM1761092, deactive class iv (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 e 1–106（106 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 15 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 13 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4C Bovine complex I in the presence of IM1761092, deactive class v (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 e 1–106（106 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 12 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4D Bovine complex I in the presence of IM1761092, deactive class vi (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 e 1–106（106 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4F Bovine complex I in the presence of IM1761092, slack class i (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 e 1–106（106 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 7 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 3 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 CDL CARDIOLIPIN × 6 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R4G Bovine complex I in the presence of IM1761092, slack class ii (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 e 1–106（106 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 LMT DODECYL-BETA-D-MALTOSIDE × 10 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.50 Å
8Q0A Inward-facing, closed proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 e 1–106（106 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 16 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 8 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 MG MAGNESIUM ION × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0F Inward-facing, open2 proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 e 1–106（106 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 21 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0J Inward-facing, slack proteoliposome complex I at 3.8 A. Initially purified in DDM. 提交 2023-07-28	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 e 1–106（106 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 4 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.80 Å
8Q0M Outward-facing, closed proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 e 1–106（106 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0O Outward-facing, open2 proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 e 1–106（106 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0Q Outward-facing, slack proteoliposome complex I at 3.6 A. Initially purified in DDM 提交 2023-07-28	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 e 1–106（106 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 4 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.60 Å
8Q1P Inward-facing, open2 proteoliposome complex I at 2.9 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 e 1–106（106 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.90 Å
8Q1U Inward-facing, open1 proteoliposome complex I at 3.3 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 e 1–106（106 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 15 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 5 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.30 Å
8Q1Y Outward-facing, open2 proteoliposome complex I at 2.6 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 e 1–106（106 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 ZN ZINC ION × 2 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q25 Outward-facing, open1 proteoliposome complex I at 2.8 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 e 1–106（106 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 ZN ZINC ION × 2 MG MAGNESIUM ION × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.80 Å
8Q45 Inward-facing, closed proteoliposome complex I at 2.7 A. Initially purified in LMNG. 提交 2023-08-05	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 e 1–106（106 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 16 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.70 Å
8Q46 Inward-facing, open2 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 e 1–106（106 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q47 Inward-facing, open1 proteoliposome complex I at 2.9 A. Initially purified in LMNG. 提交 2023-08-05	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 e 1–106（106 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 15 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 26 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 5 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.90 Å
8Q48 Outward-facing, closed proteoliposome complex I at 2.5 A. Initially purified in LMNG. 提交 2023-08-05	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 e 1–106（106 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 35 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.50 Å
8Q49 Outward-facing, open2 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 e 1–106（106 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CHD CHOLIC ACID × 1 ZN ZINC ION × 2 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 FVH [[(2~{R},3~{S},4~{R},5~{R})-5-[(3~{R})-3-aminocarbonylpiperidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{R},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3-oxidanyl-4-phosphonooxy-oxolan-2-yl]methyl hydrogen phosphate × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q4A Outward-facing, open1 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 e 1–106（106 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
9SMF Reduced bovine complex I in lipid nanodisc, NADH-active-Q10 提交 2025-09-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 e 1–106（106 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 20 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 8 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.51 Å
9SMG Reduced bovine complex I in lipid nanodisc, NADH-active-altQ10 提交 2025-09-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 e 1–106（106 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 18 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.42 Å
9SMH Reduced bovine complex I in lipid nanodisc, NADH-active-DDM 提交 2025-09-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 e 1–106（106 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 17 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 LMT DODECYL-BETA-D-MALTOSIDE × 1 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.61 Å
9SMI Reduced bovine complex I in lipid nanodisc, NADH-deactive 提交 2025-09-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 e 1–106（106 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 27 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 LMT DODECYL-BETA-D-MALTOSIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 5 CHD CHOLIC ACID × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.01 Å
9W2U Cryo-EM structure of complex I on the bovine heart submitochondrial particles, open 提交 2025-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 e 2–100（99 aa）	未记录	FME N-FORMYLMETHIONINE × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 18 CDL CARDIOLIPIN × 6 CHD CHOLIC ACID × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.60 Å
9W2V Cryo-EM structure of complex I on the bovine heart submitochondrial particles, closed 提交 2025-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 e 2–100（99 aa）	未记录	FME N-FORMYLMETHIONINE × 4 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 19 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 12 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 6 MG MAGNESIUM ION × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.80 Å

共 49 个其他 PDB 条目、49 个 assembly。 打开独立比较页并筛选聚集状态

查看构建体与数据证据

UniProt名称	NDUS5_BOVIN
Isoform	—
PDB实体	31
链与序列区间	作者链 e； PDB构建体 1–106； UniProt 1–106

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1

物种未注明

UniProt Q02378

当前结构中的状态

Assembly	聚集状态	构建体	突变与修饰	配体、离子与共同组分	实验方法与环境	结构质量
1	蛋白异源复合物 异源复合物 蛋白 × 45 PDB 声明：45-meric（45） 与蛋白拷贝数一致	链 f； UniProt 1–57	未记录	NADH-ubiquinone oxidoreductase chain 3 × 1 （P03898） NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial × 1 （P42026） NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial × 1 （P23709） NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial × 1 （P17694） NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial × 1 （P04394） NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial × 1 （P25708） ;NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, NDUFS1 ; × 1 （P15690） NADH-ubiquinone oxidoreductase chain 1 × 1 （P03887） NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial × 1 （P42028） NADH-ubiquinone oxidoreductase chain 6 × 1 （P03924） NADH-ubiquinone oxidoreductase chain 4L × 1 （P03902） NADH-ubiquinone oxidoreductase chain 5 × 1 （P03920） NADH-ubiquinone oxidoreductase chain 4 × 1 （P03910） NADH-ubiquinone oxidoreductase chain 2 × 1 （P03892） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, NDUFA10,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial ; × 1 （P34942） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial × 1 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial × 1 ;NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial ; × 1 （P23934） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 × 1 （Q02370） Acyl carrier protein, mitochondrial × 1 （P52505） Acyl carrier protein, mitochondrial × 1 （P52505） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 × 1 （P23935） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 × 1 （Q02366） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 ; × 1 （P42029） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 × 1 （Q8HXG6） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 ; × 1 （Q95KV7） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 × 1 （Q02377） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 ; × 1 （Q02371） NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial × 1 （Q02376） ;NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2 ; × 1 （Q02827） NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 × 1 （Q02379） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial × 1 （Q8HXG5） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial ; × 1 （Q02380） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 ; × 1 （Q02367） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, NDUFB2 × 1 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3, NDUFB3 × 1 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, NDUFB8 × 1 ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 ; × 1 （P48305） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 ; × 1 （Q02369） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 × 1 （Q02368） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10, NDUFB10,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10, NDUFB10 ; × 1 （Q02373） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 × 1 （O97725） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7, NDUFA7 × 1 NADH dehydrogenase [ubiquinone] flavoprotein 3, NDUFV3 × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液：pH 8 cryo-EM玻璃化条件：冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 4.35 Å

数据库中的同蛋白其他状态

以下每一行都是同一 UniProt 蛋白在另一个 PDB 条目中的 biological assembly， “相对当前条目”直接指出证据层面的不同；没有差异标签表示当前已读取字段一致。

其他 PDB	相对当前条目 5LC5	Assembly / 聚集状态	构建体	突变与修饰	配体、离子与非聚合物	实验方法与环境	结构质量
5LDW Structure of mammalian respiratory Complex I, class1 提交 2016-06-28	实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 f 1–57（57 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8；20 mM TRIS-HCL, 150 mM NaCl, 0.03% CYMAL-7 cryo-EM玻璃化条件 冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus present in a cold room, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 4.27 Å
5LDX Structure of mammalian respiratory Complex I, class3. 提交 2016-06-28	结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 f 1–57（57 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 20 mM TRIS-HCL, 150 mM NaCl, 0.03% CYMAL-7；pH 8 cryo-EM玻璃化条件 冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 5.60 Å
5O31 Mitochondrial complex I in the deactive state 提交 2017-05-23	实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 f 1–57（57 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.55 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.13 Å
7DGQ Activity optimized supercomplex state1 提交 2020-11-12	聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 X 1–57（57 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 CU COPPER (II) ION × 3 HEA HEME-A × 2 MG MAGNESIUM ION × 1 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 UQ2 UBIQUINONE-2 × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 5.00 Å
7DGR Activity optimized supercomplex state2 提交 2020-11-12	聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 X 1–57（57 aa）	未记录	FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 3 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.60 Å
7DGS Activity optimized supercomplex state3 提交 2020-11-12	聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 X 1–57（57 aa）	未记录	FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 7.80 Å
7DGZ Activity optimized complex I (closed form) 提交 2020-11-12	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 X 1–57（57 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 2 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 3.80 Å
7DH0 Activity optimized complex I (open form) 提交 2020-11-12	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 X 1–57（57 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.20 Å
7DKF Activity optimized supercomplex state4 提交 2020-11-24	聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 X2 1–57（57 aa）	未记录	HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 8.30 Å
7QSD Bovine complex I in the active state at 3.1 A 提交 2022-01-13	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 f 1–57（57 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 13 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 CDL CARDIOLIPIN × 4 LMT DODECYL-BETA-D-MALTOSIDE × 3 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 3.10 Å
7QSK Bovine complex I in lipid nanodisc, Active-Q10 提交 2022-01-13	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 f 1–57（57 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 19 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.84 Å
7QSL Bovine complex I in lipid nanodisc, Active-apo 提交 2022-01-13	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 f 1–57（57 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 20 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 8 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.76 Å
7QSM Bovine complex I in lipid nanodisc, Deactive-ligand (composite) 提交 2022-01-13	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 f 1–57（57 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 GOL GLYCEROL × 1 LMT DODECYL-BETA-D-MALTOSIDE × 1 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.30 Å
7QSN Bovine complex I in lipid nanodisc, Deactive-apo 提交 2022-01-13	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 f 1–57（57 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 6 CHD CHOLIC ACID × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.81 Å
7QSO Bovine complex I in lipid nanodisc, State 3 (Slack) 提交 2022-01-13	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 f 1–57（57 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 6 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CHD CHOLIC ACID × 2 CDL CARDIOLIPIN × 6 U10 UBIQUINONE-10 × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 3.02 Å
7R41 Bovine complex I in the presence of IM1761092, active class i (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 f 1–57（57 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 16 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R42 Bovine complex I in the presence of IM1761092, active class ii (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 f 1–57（57 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 17 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R43 Bovine complex I in the presence of IM1761092, active class iii (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 f 1–57（57 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 CDL CARDIOLIPIN × 5 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R44 Bovine complex I in the presence of IM1761092, active class iv (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 f 1–57（57 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 11 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R45 Bovine complex I in the presence of IM1761092, deactive class i (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 f 1–57（57 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R46 Bovine complex I in the presence of IM1761092, deactive class ii (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 f 1–57（57 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 11 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R47 Bovine complex I in the presence of IM1761092, deactive class iii (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 f 1–57（57 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R48 Bovine complex I in the presence of IM1761092, deactive class iv (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 f 1–57（57 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 15 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 13 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4C Bovine complex I in the presence of IM1761092, deactive class v (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 f 1–57（57 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 12 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4D Bovine complex I in the presence of IM1761092, deactive class vi (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 f 1–57（57 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4F Bovine complex I in the presence of IM1761092, slack class i (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 f 1–57（57 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 7 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 3 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 CDL CARDIOLIPIN × 6 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R4G Bovine complex I in the presence of IM1761092, slack class ii (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 f 1–57（57 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 LMT DODECYL-BETA-D-MALTOSIDE × 10 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.50 Å
8Q0A Inward-facing, closed proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 f 1–57（57 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 16 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 8 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 MG MAGNESIUM ION × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0F Inward-facing, open2 proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 f 1–57（57 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 21 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0J Inward-facing, slack proteoliposome complex I at 3.8 A. Initially purified in DDM. 提交 2023-07-28	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 f 1–57（57 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 4 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.80 Å
8Q0M Outward-facing, closed proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 f 1–57（57 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0O Outward-facing, open2 proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 f 1–57（57 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0Q Outward-facing, slack proteoliposome complex I at 3.6 A. Initially purified in DDM 提交 2023-07-28	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 f 1–57（57 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 4 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.60 Å
8Q1P Inward-facing, open2 proteoliposome complex I at 2.9 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 f 1–57（57 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.90 Å
8Q1U Inward-facing, open1 proteoliposome complex I at 3.3 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 f 1–57（57 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 15 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 5 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.30 Å
8Q1Y Outward-facing, open2 proteoliposome complex I at 2.6 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 f 1–57（57 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 ZN ZINC ION × 2 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q25 Outward-facing, open1 proteoliposome complex I at 2.8 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 f 1–57（57 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 ZN ZINC ION × 2 MG MAGNESIUM ION × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.80 Å
8Q45 Inward-facing, closed proteoliposome complex I at 2.7 A. Initially purified in LMNG. 提交 2023-08-05	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 f 1–57（57 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 16 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.70 Å
8Q46 Inward-facing, open2 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 f 1–57（57 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q47 Inward-facing, open1 proteoliposome complex I at 2.9 A. Initially purified in LMNG. 提交 2023-08-05	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 f 1–57（57 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 15 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 26 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 5 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.90 Å
8Q48 Outward-facing, closed proteoliposome complex I at 2.5 A. Initially purified in LMNG. 提交 2023-08-05	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 f 1–57（57 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 35 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.50 Å
8Q49 Outward-facing, open2 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 f 1–57（57 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CHD CHOLIC ACID × 1 ZN ZINC ION × 2 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 FVH [[(2~{R},3~{S},4~{R},5~{R})-5-[(3~{R})-3-aminocarbonylpiperidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{R},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3-oxidanyl-4-phosphonooxy-oxolan-2-yl]methyl hydrogen phosphate × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q4A Outward-facing, open1 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 f 1–57（57 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
9SMF Reduced bovine complex I in lipid nanodisc, NADH-active-Q10 提交 2025-09-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 f 1–57（57 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 20 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 8 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.51 Å
9SMG Reduced bovine complex I in lipid nanodisc, NADH-active-altQ10 提交 2025-09-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 f 1–57（57 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 18 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.42 Å
9SMH Reduced bovine complex I in lipid nanodisc, NADH-active-DDM 提交 2025-09-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 f 1–57（57 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 17 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 LMT DODECYL-BETA-D-MALTOSIDE × 1 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.61 Å
9SMI Reduced bovine complex I in lipid nanodisc, NADH-deactive 提交 2025-09-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 f 1–57（57 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 27 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 LMT DODECYL-BETA-D-MALTOSIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 5 CHD CHOLIC ACID × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.01 Å
9W2U Cryo-EM structure of complex I on the bovine heart submitochondrial particles, open 提交 2025-07-28	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 f 1–57（57 aa）	未记录	FME N-FORMYLMETHIONINE × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 18 CDL CARDIOLIPIN × 6 CHD CHOLIC ACID × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.60 Å
9W2V Cryo-EM structure of complex I on the bovine heart submitochondrial particles, closed 提交 2025-07-28	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 f 1–57（57 aa）	未记录	FME N-FORMYLMETHIONINE × 4 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 19 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 12 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 6 MG MAGNESIUM ION × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.80 Å

共 49 个其他 PDB 条目、49 个 assembly。 打开独立比较页并筛选聚集状态

查看构建体与数据证据

UniProt名称	NDUB1_BOVIN
Isoform	—
PDB实体	32
链与序列区间	作者链 f； PDB构建体 1–57； UniProt 1–57

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial

物种未注明

UniProt Q8HXG5

当前结构中的状态

Assembly	聚集状态	构建体	突变与修饰	配体、离子与共同组分	实验方法与环境	结构质量
1	蛋白异源复合物 异源复合物 蛋白 × 45 PDB 声明：45-meric（45） 与蛋白拷贝数一致	链 g； UniProt 1–154	未记录	NADH-ubiquinone oxidoreductase chain 3 × 1 （P03898） NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial × 1 （P42026） NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial × 1 （P23709） NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial × 1 （P17694） NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial × 1 （P04394） NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial × 1 （P25708） ;NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, NDUFS1 ; × 1 （P15690） NADH-ubiquinone oxidoreductase chain 1 × 1 （P03887） NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial × 1 （P42028） NADH-ubiquinone oxidoreductase chain 6 × 1 （P03924） NADH-ubiquinone oxidoreductase chain 4L × 1 （P03902） NADH-ubiquinone oxidoreductase chain 5 × 1 （P03920） NADH-ubiquinone oxidoreductase chain 4 × 1 （P03910） NADH-ubiquinone oxidoreductase chain 2 × 1 （P03892） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, NDUFA10,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial ; × 1 （P34942） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial × 1 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial × 1 ;NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial ; × 1 （P23934） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 × 1 （Q02370） Acyl carrier protein, mitochondrial × 1 （P52505） Acyl carrier protein, mitochondrial × 1 （P52505） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 × 1 （P23935） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 × 1 （Q02366） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 ; × 1 （P42029） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 × 1 （Q8HXG6） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 ; × 1 （Q95KV7） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 × 1 （Q02377） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 ; × 1 （Q02371） NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial × 1 （Q02376） ;NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2 ; × 1 （Q02827） NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 × 1 （Q02379） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 × 1 （Q02378） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial ; × 1 （Q02380） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 ; × 1 （Q02367） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, NDUFB2 × 1 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3, NDUFB3 × 1 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, NDUFB8 × 1 ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 ; × 1 （P48305） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 ; × 1 （Q02369） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 × 1 （Q02368） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10, NDUFB10,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10, NDUFB10 ; × 1 （Q02373） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 × 1 （O97725） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7, NDUFA7 × 1 NADH dehydrogenase [ubiquinone] flavoprotein 3, NDUFV3 × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液：pH 8 cryo-EM玻璃化条件：冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 4.35 Å

数据库中的同蛋白其他状态

以下每一行都是同一 UniProt 蛋白在另一个 PDB 条目中的 biological assembly， “相对当前条目”直接指出证据层面的不同；没有差异标签表示当前已读取字段一致。

其他 PDB	相对当前条目 5LC5	Assembly / 聚集状态	构建体	突变与修饰	配体、离子与非聚合物	实验方法与环境	结构质量
5LDW Structure of mammalian respiratory Complex I, class1 提交 2016-06-28	构建体不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 g 30–154（125 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8；20 mM TRIS-HCL, 150 mM NaCl, 0.03% CYMAL-7 cryo-EM玻璃化条件 冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus present in a cold room, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 4.27 Å
5LDX Structure of mammalian respiratory Complex I, class3. 提交 2016-06-28	构建体不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 g 30–154（125 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 20 mM TRIS-HCL, 150 mM NaCl, 0.03% CYMAL-7；pH 8 cryo-EM玻璃化条件 冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 5.60 Å
5O31 Mitochondrial complex I in the deactive state 提交 2017-05-23	构建体不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 g 30–154（125 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.55 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.13 Å
7DGQ Activity optimized supercomplex state1 提交 2020-11-12	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 h 30–154（125 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 CU COPPER (II) ION × 3 HEA HEME-A × 2 MG MAGNESIUM ION × 1 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 UQ2 UBIQUINONE-2 × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 5.00 Å
7DGR Activity optimized supercomplex state2 提交 2020-11-12	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 h 30–154（125 aa）	未记录	FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 3 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.60 Å
7DGS Activity optimized supercomplex state3 提交 2020-11-12	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 h 30–154（125 aa）	未记录	FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 7.80 Å
7DGZ Activity optimized complex I (closed form) 提交 2020-11-12	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 h 30–154（125 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 2 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 3.80 Å
7DH0 Activity optimized complex I (open form) 提交 2020-11-12	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 h 30–154（125 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.20 Å
7DKF Activity optimized supercomplex state4 提交 2020-11-24	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 h2 30–154（125 aa）	未记录	HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 8.30 Å
7QSD Bovine complex I in the active state at 3.1 A 提交 2022-01-13	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 g 1–154（154 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 13 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 CDL CARDIOLIPIN × 4 LMT DODECYL-BETA-D-MALTOSIDE × 3 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 3.10 Å
7QSK Bovine complex I in lipid nanodisc, Active-Q10 提交 2022-01-13	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 g 1–154（154 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 19 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.84 Å
7QSL Bovine complex I in lipid nanodisc, Active-apo 提交 2022-01-13	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 g 1–154（154 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 20 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 8 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.76 Å
7QSM Bovine complex I in lipid nanodisc, Deactive-ligand (composite) 提交 2022-01-13	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 g 1–154（154 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 GOL GLYCEROL × 1 LMT DODECYL-BETA-D-MALTOSIDE × 1 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.30 Å
7QSN Bovine complex I in lipid nanodisc, Deactive-apo 提交 2022-01-13	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 g 1–154（154 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 6 CHD CHOLIC ACID × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.81 Å
7QSO Bovine complex I in lipid nanodisc, State 3 (Slack) 提交 2022-01-13	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 g 1–154（154 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 6 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CHD CHOLIC ACID × 2 CDL CARDIOLIPIN × 6 U10 UBIQUINONE-10 × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 3.02 Å
7R41 Bovine complex I in the presence of IM1761092, active class i (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 g 1–154（154 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 16 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R42 Bovine complex I in the presence of IM1761092, active class ii (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 g 1–154（154 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 17 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R43 Bovine complex I in the presence of IM1761092, active class iii (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 g 1–154（154 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 CDL CARDIOLIPIN × 5 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R44 Bovine complex I in the presence of IM1761092, active class iv (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 g 1–154（154 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 11 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R45 Bovine complex I in the presence of IM1761092, deactive class i (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 g 1–154（154 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R46 Bovine complex I in the presence of IM1761092, deactive class ii (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 g 1–154（154 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 11 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R47 Bovine complex I in the presence of IM1761092, deactive class iii (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 g 1–154（154 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R48 Bovine complex I in the presence of IM1761092, deactive class iv (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 g 1–154（154 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 15 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 13 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4C Bovine complex I in the presence of IM1761092, deactive class v (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 g 1–154（154 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 12 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4D Bovine complex I in the presence of IM1761092, deactive class vi (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 g 1–154（154 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4F Bovine complex I in the presence of IM1761092, slack class i (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 g 1–154（154 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 7 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 3 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 CDL CARDIOLIPIN × 6 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R4G Bovine complex I in the presence of IM1761092, slack class ii (Composite map) 提交 2022-02-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 g 1–154（154 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 LMT DODECYL-BETA-D-MALTOSIDE × 10 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.50 Å
8Q0A Inward-facing, closed proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 g 1–154（154 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 16 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 8 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 MG MAGNESIUM ION × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0F Inward-facing, open2 proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 g 1–154（154 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 21 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0J Inward-facing, slack proteoliposome complex I at 3.8 A. Initially purified in DDM. 提交 2023-07-28	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 g 1–154（154 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 4 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.80 Å
8Q0M Outward-facing, closed proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 g 1–154（154 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0O Outward-facing, open2 proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 g 1–154（154 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0Q Outward-facing, slack proteoliposome complex I at 3.6 A. Initially purified in DDM 提交 2023-07-28	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 g 1–154（154 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 4 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.60 Å
8Q1P Inward-facing, open2 proteoliposome complex I at 2.9 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 g 1–154（154 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.90 Å
8Q1U Inward-facing, open1 proteoliposome complex I at 3.3 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 g 1–154（154 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 15 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 5 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.30 Å
8Q1Y Outward-facing, open2 proteoliposome complex I at 2.6 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 g 1–154（154 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 ZN ZINC ION × 2 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q25 Outward-facing, open1 proteoliposome complex I at 2.8 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 g 1–154（154 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 ZN ZINC ION × 2 MG MAGNESIUM ION × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.80 Å
8Q45 Inward-facing, closed proteoliposome complex I at 2.7 A. Initially purified in LMNG. 提交 2023-08-05	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 g 1–154（154 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 16 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.70 Å
8Q46 Inward-facing, open2 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 g 1–154（154 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q47 Inward-facing, open1 proteoliposome complex I at 2.9 A. Initially purified in LMNG. 提交 2023-08-05	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 g 1–154（154 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 15 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 26 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 5 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.90 Å
8Q48 Outward-facing, closed proteoliposome complex I at 2.5 A. Initially purified in LMNG. 提交 2023-08-05	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 g 1–154（154 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 35 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.50 Å
8Q49 Outward-facing, open2 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 g 1–154（154 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CHD CHOLIC ACID × 1 ZN ZINC ION × 2 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 FVH [[(2~{R},3~{S},4~{R},5~{R})-5-[(3~{R})-3-aminocarbonylpiperidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{R},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3-oxidanyl-4-phosphonooxy-oxolan-2-yl]methyl hydrogen phosphate × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q4A Outward-facing, open1 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 g 1–154（154 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
9SMF Reduced bovine complex I in lipid nanodisc, NADH-active-Q10 提交 2025-09-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 g 1–154（154 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 20 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 8 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.51 Å
9SMG Reduced bovine complex I in lipid nanodisc, NADH-active-altQ10 提交 2025-09-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 g 1–154（154 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 18 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.42 Å
9SMH Reduced bovine complex I in lipid nanodisc, NADH-active-DDM 提交 2025-09-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 g 1–154（154 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 17 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 LMT DODECYL-BETA-D-MALTOSIDE × 1 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.61 Å
9SMI Reduced bovine complex I in lipid nanodisc, NADH-deactive 提交 2025-09-08	配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 g 1–154（154 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 27 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 LMT DODECYL-BETA-D-MALTOSIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 5 CHD CHOLIC ACID × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.01 Å
9W2U Cryo-EM structure of complex I on the bovine heart submitochondrial particles, open 提交 2025-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 g 52–151（100 aa）	未记录	FME N-FORMYLMETHIONINE × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 18 CDL CARDIOLIPIN × 6 CHD CHOLIC ACID × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.60 Å
9W2V Cryo-EM structure of complex I on the bovine heart submitochondrial particles, closed 提交 2025-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 g 52–151（100 aa）	未记录	FME N-FORMYLMETHIONINE × 4 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 19 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 12 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 6 MG MAGNESIUM ION × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.80 Å

共 49 个其他 PDB 条目、49 个 assembly。 打开独立比较页并筛选聚集状态

查看构建体与数据证据

UniProt名称	NDUBB_BOVIN
Isoform	—
PDB实体	33
链与序列区间	作者链 g； PDB构建体 1–154； UniProt 1–154

;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial ;

物种未注明

UniProt Q02380

当前结构中的状态

Assembly	聚集状态	构建体	突变与修饰	配体、离子与共同组分	实验方法与环境	结构质量
1	蛋白异源复合物 异源复合物 蛋白 × 45 PDB 声明：45-meric（45） 与蛋白拷贝数一致	链 h； UniProt 1–91	未记录	NADH-ubiquinone oxidoreductase chain 3 × 1 （P03898） NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial × 1 （P42026） NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial × 1 （P23709） NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial × 1 （P17694） NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial × 1 （P04394） NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial × 1 （P25708） ;NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, NDUFS1 ; × 1 （P15690） NADH-ubiquinone oxidoreductase chain 1 × 1 （P03887） NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial × 1 （P42028） NADH-ubiquinone oxidoreductase chain 6 × 1 （P03924） NADH-ubiquinone oxidoreductase chain 4L × 1 （P03902） NADH-ubiquinone oxidoreductase chain 5 × 1 （P03920） NADH-ubiquinone oxidoreductase chain 4 × 1 （P03910） NADH-ubiquinone oxidoreductase chain 2 × 1 （P03892） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, NDUFA10,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial ; × 1 （P34942） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial × 1 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial × 1 ;NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial ; × 1 （P23934） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 × 1 （Q02370） Acyl carrier protein, mitochondrial × 1 （P52505） Acyl carrier protein, mitochondrial × 1 （P52505） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 × 1 （P23935） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 × 1 （Q02366） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 ; × 1 （P42029） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 × 1 （Q8HXG6） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 ; × 1 （Q95KV7） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 × 1 （Q02377） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 ; × 1 （Q02371） NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial × 1 （Q02376） ;NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2 ; × 1 （Q02827） NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 × 1 （Q02379） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 × 1 （Q02378） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial × 1 （Q8HXG5） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 ; × 1 （Q02367） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, NDUFB2 × 1 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3, NDUFB3 × 1 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, NDUFB8 × 1 ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 ; × 1 （P48305） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 ; × 1 （Q02369） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 × 1 （Q02368） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10, NDUFB10,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10, NDUFB10 ; × 1 （Q02373） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 × 1 （O97725） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7, NDUFA7 × 1 NADH dehydrogenase [ubiquinone] flavoprotein 3, NDUFV3 × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液：pH 8 cryo-EM玻璃化条件：冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 4.35 Å

数据库中的同蛋白其他状态

以下每一行都是同一 UniProt 蛋白在另一个 PDB 条目中的 biological assembly， “相对当前条目”直接指出证据层面的不同；没有差异标签表示当前已读取字段一致。

其他 PDB	相对当前条目 5LC5	Assembly / 聚集状态	构建体	突变与修饰	配体、离子与非聚合物	实验方法与环境	结构质量
5LDW Structure of mammalian respiratory Complex I, class1 提交 2016-06-28	构建体不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 h 53–91（39 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8；20 mM TRIS-HCL, 150 mM NaCl, 0.03% CYMAL-7 cryo-EM玻璃化条件 冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus present in a cold room, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 4.27 Å
5LDX Structure of mammalian respiratory Complex I, class3. 提交 2016-06-28	构建体不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 h 53–91（39 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 20 mM TRIS-HCL, 150 mM NaCl, 0.03% CYMAL-7；pH 8 cryo-EM玻璃化条件 冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 5.60 Å
5O31 Mitochondrial complex I in the deactive state 提交 2017-05-23	构建体不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 h 47–189（143 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.55 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.13 Å
7DGQ Activity optimized supercomplex state1 提交 2020-11-12	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 b 47–189（143 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 CU COPPER (II) ION × 3 HEA HEME-A × 2 MG MAGNESIUM ION × 1 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 UQ2 UBIQUINONE-2 × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 5.00 Å
7DGR Activity optimized supercomplex state2 提交 2020-11-12	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 b 47–189（143 aa）	未记录	FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 3 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.60 Å
7DGS Activity optimized supercomplex state3 提交 2020-11-12	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 b 47–189（143 aa）	未记录	FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 7.80 Å
7DGZ Activity optimized complex I (closed form) 提交 2020-11-12	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 b 47–189（143 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 2 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 3.80 Å
7DH0 Activity optimized complex I (open form) 提交 2020-11-12	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 b 47–189（143 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.20 Å
7DKF Activity optimized supercomplex state4 提交 2020-11-24	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 b2 47–189（143 aa）	未记录	HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 8.30 Å
7QSD Bovine complex I in the active state at 3.1 A 提交 2022-01-13	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 h 1–189（189 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 13 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 CDL CARDIOLIPIN × 4 LMT DODECYL-BETA-D-MALTOSIDE × 3 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 3.10 Å
7QSK Bovine complex I in lipid nanodisc, Active-Q10 提交 2022-01-13	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 h 1–189（189 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 19 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.84 Å
7QSL Bovine complex I in lipid nanodisc, Active-apo 提交 2022-01-13	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 h 1–189（189 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 20 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 8 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.76 Å
7QSM Bovine complex I in lipid nanodisc, Deactive-ligand (composite) 提交 2022-01-13	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 h 1–189（189 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 GOL GLYCEROL × 1 LMT DODECYL-BETA-D-MALTOSIDE × 1 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.30 Å
7QSN Bovine complex I in lipid nanodisc, Deactive-apo 提交 2022-01-13	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 h 1–189（189 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 6 CHD CHOLIC ACID × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.81 Å
7QSO Bovine complex I in lipid nanodisc, State 3 (Slack) 提交 2022-01-13	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 h 1–189（189 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 6 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CHD CHOLIC ACID × 2 CDL CARDIOLIPIN × 6 U10 UBIQUINONE-10 × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 3.02 Å
7R41 Bovine complex I in the presence of IM1761092, active class i (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 h 1–189（189 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 16 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R42 Bovine complex I in the presence of IM1761092, active class ii (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 h 1–189（189 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 17 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R43 Bovine complex I in the presence of IM1761092, active class iii (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 h 1–189（189 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 CDL CARDIOLIPIN × 5 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R44 Bovine complex I in the presence of IM1761092, active class iv (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 h 1–189（189 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 11 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R45 Bovine complex I in the presence of IM1761092, deactive class i (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 h 1–189（189 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R46 Bovine complex I in the presence of IM1761092, deactive class ii (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 h 1–189（189 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 11 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R47 Bovine complex I in the presence of IM1761092, deactive class iii (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 h 1–189（189 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R48 Bovine complex I in the presence of IM1761092, deactive class iv (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 h 1–189（189 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 15 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 13 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4C Bovine complex I in the presence of IM1761092, deactive class v (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 h 1–189（189 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 12 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4D Bovine complex I in the presence of IM1761092, deactive class vi (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 h 1–189（189 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4F Bovine complex I in the presence of IM1761092, slack class i (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 h 1–189（189 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 7 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 3 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 CDL CARDIOLIPIN × 6 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R4G Bovine complex I in the presence of IM1761092, slack class ii (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 h 1–189（189 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 LMT DODECYL-BETA-D-MALTOSIDE × 10 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.50 Å
8Q0A Inward-facing, closed proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 h 1–189（189 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 16 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 8 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 MG MAGNESIUM ION × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0F Inward-facing, open2 proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 h 1–189（189 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 21 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0J Inward-facing, slack proteoliposome complex I at 3.8 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 h 1–189（189 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 4 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.80 Å
8Q0M Outward-facing, closed proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 h 1–189（189 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0O Outward-facing, open2 proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 h 1–189（189 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0Q Outward-facing, slack proteoliposome complex I at 3.6 A. Initially purified in DDM 提交 2023-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 h 1–189（189 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 4 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.60 Å
8Q1P Inward-facing, open2 proteoliposome complex I at 2.9 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 h 1–189（189 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.90 Å
8Q1U Inward-facing, open1 proteoliposome complex I at 3.3 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 h 1–189（189 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 15 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 5 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.30 Å
8Q1Y Outward-facing, open2 proteoliposome complex I at 2.6 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 h 1–189（189 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 ZN ZINC ION × 2 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q25 Outward-facing, open1 proteoliposome complex I at 2.8 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 h 1–189（189 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 ZN ZINC ION × 2 MG MAGNESIUM ION × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.80 Å
8Q45 Inward-facing, closed proteoliposome complex I at 2.7 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 h 1–189（189 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 16 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.70 Å
8Q46 Inward-facing, open2 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 h 1–189（189 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q47 Inward-facing, open1 proteoliposome complex I at 2.9 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 h 1–189（189 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 15 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 26 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 5 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.90 Å
8Q48 Outward-facing, closed proteoliposome complex I at 2.5 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 h 1–189（189 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 35 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.50 Å
8Q49 Outward-facing, open2 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 h 1–189（189 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CHD CHOLIC ACID × 1 ZN ZINC ION × 2 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 FVH [[(2~{R},3~{S},4~{R},5~{R})-5-[(3~{R})-3-aminocarbonylpiperidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{R},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3-oxidanyl-4-phosphonooxy-oxolan-2-yl]methyl hydrogen phosphate × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q4A Outward-facing, open1 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 h 1–189（189 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
9SMF Reduced bovine complex I in lipid nanodisc, NADH-active-Q10 提交 2025-09-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 h 1–189（189 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 20 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 8 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.51 Å
9SMG Reduced bovine complex I in lipid nanodisc, NADH-active-altQ10 提交 2025-09-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 h 1–189（189 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 18 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.42 Å
9SMH Reduced bovine complex I in lipid nanodisc, NADH-active-DDM 提交 2025-09-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 h 1–189（189 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 17 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 LMT DODECYL-BETA-D-MALTOSIDE × 1 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.61 Å
9SMI Reduced bovine complex I in lipid nanodisc, NADH-deactive 提交 2025-09-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 h 1–189（189 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 27 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 LMT DODECYL-BETA-D-MALTOSIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 5 CHD CHOLIC ACID × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.01 Å
9W2U Cryo-EM structure of complex I on the bovine heart submitochondrial particles, open 提交 2025-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 h 52–189（138 aa）	未记录	FME N-FORMYLMETHIONINE × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 18 CDL CARDIOLIPIN × 6 CHD CHOLIC ACID × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.60 Å
9W2V Cryo-EM structure of complex I on the bovine heart submitochondrial particles, closed 提交 2025-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 h 52–189（138 aa）	未记录	FME N-FORMYLMETHIONINE × 4 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 19 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 12 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 6 MG MAGNESIUM ION × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.80 Å

共 49 个其他 PDB 条目、49 个 assembly。 打开独立比较页并筛选聚集状态

查看构建体与数据证据

UniProt名称	NDUB5_BOVIN
Isoform	—
PDB实体	34
链与序列区间	作者链 h； PDB构建体 1–91； UniProt 1–91

;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 ;

物种未注明

UniProt Q02367

当前结构中的状态

Assembly	聚集状态	构建体	突变与修饰	配体、离子与共同组分	实验方法与环境	结构质量
1	蛋白异源复合物 异源复合物 蛋白 × 45 PDB 声明：45-meric（45） 与蛋白拷贝数一致	链 i； UniProt 1–33	未记录	NADH-ubiquinone oxidoreductase chain 3 × 1 （P03898） NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial × 1 （P42026） NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial × 1 （P23709） NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial × 1 （P17694） NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial × 1 （P04394） NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial × 1 （P25708） ;NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, NDUFS1 ; × 1 （P15690） NADH-ubiquinone oxidoreductase chain 1 × 1 （P03887） NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial × 1 （P42028） NADH-ubiquinone oxidoreductase chain 6 × 1 （P03924） NADH-ubiquinone oxidoreductase chain 4L × 1 （P03902） NADH-ubiquinone oxidoreductase chain 5 × 1 （P03920） NADH-ubiquinone oxidoreductase chain 4 × 1 （P03910） NADH-ubiquinone oxidoreductase chain 2 × 1 （P03892） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, NDUFA10,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial ; × 1 （P34942） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial × 1 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial × 1 ;NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial ; × 1 （P23934） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 × 1 （Q02370） Acyl carrier protein, mitochondrial × 1 （P52505） Acyl carrier protein, mitochondrial × 1 （P52505） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 × 1 （P23935） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 × 1 （Q02366） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 ; × 1 （P42029） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 × 1 （Q8HXG6） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 ; × 1 （Q95KV7） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 × 1 （Q02377） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 ; × 1 （Q02371） NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial × 1 （Q02376） ;NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2 ; × 1 （Q02827） NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 × 1 （Q02379） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 × 1 （Q02378） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial × 1 （Q8HXG5） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial ; × 1 （Q02380） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, NDUFB2 × 1 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3, NDUFB3 × 1 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, NDUFB8 × 1 ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 ; × 1 （P48305） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 ; × 1 （Q02369） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 × 1 （Q02368） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10, NDUFB10,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10, NDUFB10 ; × 1 （Q02373） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 × 1 （O97725） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7, NDUFA7 × 1 NADH dehydrogenase [ubiquinone] flavoprotein 3, NDUFV3 × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液：pH 8 cryo-EM玻璃化条件：冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 4.35 Å

数据库中的同蛋白其他状态

以下每一行都是同一 UniProt 蛋白在另一个 PDB 条目中的 biological assembly， “相对当前条目”直接指出证据层面的不同；没有差异标签表示当前已读取字段一致。

其他 PDB	相对当前条目 5LC5	Assembly / 聚集状态	构建体	突变与修饰	配体、离子与非聚合物	实验方法与环境	结构质量
5LDW Structure of mammalian respiratory Complex I, class1 提交 2016-06-28	构建体不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 i 7–33（27 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8；20 mM TRIS-HCL, 150 mM NaCl, 0.03% CYMAL-7 cryo-EM玻璃化条件 冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus present in a cold room, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 4.27 Å
5LDX Structure of mammalian respiratory Complex I, class3. 提交 2016-06-28	构建体不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 i 7–33（27 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 20 mM TRIS-HCL, 150 mM NaCl, 0.03% CYMAL-7；pH 8 cryo-EM玻璃化条件 冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 5.60 Å
5O31 Mitochondrial complex I in the deactive state 提交 2017-05-23	构建体不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 i 2–33（32 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.55 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.13 Å
7DGQ Activity optimized supercomplex state1 提交 2020-11-12	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 c 1–128（128 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 CU COPPER (II) ION × 3 HEA HEME-A × 2 MG MAGNESIUM ION × 1 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 UQ2 UBIQUINONE-2 × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 5.00 Å
7DGR Activity optimized supercomplex state2 提交 2020-11-12	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 c 1–128（128 aa）	未记录	FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 3 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.60 Å
7DGS Activity optimized supercomplex state3 提交 2020-11-12	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 c 2–128（127 aa）	未记录	FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 7.80 Å
7DGZ Activity optimized complex I (closed form) 提交 2020-11-12	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 c 2–128（127 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 2 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 3.80 Å
7DH0 Activity optimized complex I (open form) 提交 2020-11-12	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 c 2–128（127 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.20 Å
7DKF Activity optimized supercomplex state4 提交 2020-11-24	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 c2 2–128（127 aa）	未记录	HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 8.30 Å
7QSD Bovine complex I in the active state at 3.1 A 提交 2022-01-13	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 i 2–128（127 aa）	非标准单体：是（mmCIF未提供具体位点）	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 13 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 CDL CARDIOLIPIN × 4 LMT DODECYL-BETA-D-MALTOSIDE × 3 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 3.10 Å
7QSK Bovine complex I in lipid nanodisc, Active-Q10 提交 2022-01-13	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 i 2–128（127 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 19 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.84 Å
7QSL Bovine complex I in lipid nanodisc, Active-apo 提交 2022-01-13	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 i 2–128（127 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 20 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 8 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.76 Å
7QSM Bovine complex I in lipid nanodisc, Deactive-ligand (composite) 提交 2022-01-13	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 i 2–128（127 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 GOL GLYCEROL × 1 LMT DODECYL-BETA-D-MALTOSIDE × 1 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.30 Å
7QSN Bovine complex I in lipid nanodisc, Deactive-apo 提交 2022-01-13	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 i 2–128（127 aa）	非标准单体：是（mmCIF未提供具体位点）	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 6 CHD CHOLIC ACID × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.81 Å
7QSO Bovine complex I in lipid nanodisc, State 3 (Slack) 提交 2022-01-13	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 i 2–128（127 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 6 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CHD CHOLIC ACID × 2 CDL CARDIOLIPIN × 6 U10 UBIQUINONE-10 × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 3.02 Å
7R41 Bovine complex I in the presence of IM1761092, active class i (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 i 2–128（127 aa）	非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 16 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R42 Bovine complex I in the presence of IM1761092, active class ii (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 i 2–128（127 aa）	非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 17 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R43 Bovine complex I in the presence of IM1761092, active class iii (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 i 2–128（127 aa）	非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 CDL CARDIOLIPIN × 5 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R44 Bovine complex I in the presence of IM1761092, active class iv (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 i 2–128（127 aa）	非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 11 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R45 Bovine complex I in the presence of IM1761092, deactive class i (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 i 2–128（127 aa）	非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R46 Bovine complex I in the presence of IM1761092, deactive class ii (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 i 2–128（127 aa）	非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 11 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R47 Bovine complex I in the presence of IM1761092, deactive class iii (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 i 2–128（127 aa）	非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R48 Bovine complex I in the presence of IM1761092, deactive class iv (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 i 2–128（127 aa）	非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 15 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 13 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4C Bovine complex I in the presence of IM1761092, deactive class v (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 i 2–128（127 aa）	非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 12 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4D Bovine complex I in the presence of IM1761092, deactive class vi (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 i 2–128（127 aa）	非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4F Bovine complex I in the presence of IM1761092, slack class i (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 i 2–128（127 aa）	非标准单体：是（mmCIF未提供具体位点）	LMT DODECYL-BETA-D-MALTOSIDE × 7 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 3 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 CDL CARDIOLIPIN × 6 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R4G Bovine complex I in the presence of IM1761092, slack class ii (Composite map) 提交 2022-02-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 i 2–128（127 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 LMT DODECYL-BETA-D-MALTOSIDE × 10 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.50 Å
8Q0A Inward-facing, closed proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 i 1–128（128 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 16 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 8 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 MG MAGNESIUM ION × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0F Inward-facing, open2 proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 i 1–128（128 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 21 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0J Inward-facing, slack proteoliposome complex I at 3.8 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 i 1–128（128 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 4 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.80 Å
8Q0M Outward-facing, closed proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 i 1–128（128 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0O Outward-facing, open2 proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 i 1–128（128 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0Q Outward-facing, slack proteoliposome complex I at 3.6 A. Initially purified in DDM 提交 2023-07-28	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 i 1–128（128 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 4 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.60 Å
8Q1P Inward-facing, open2 proteoliposome complex I at 2.9 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 i 1–128（128 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.90 Å
8Q1U Inward-facing, open1 proteoliposome complex I at 3.3 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 i 1–128（128 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 15 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 5 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.30 Å
8Q1Y Outward-facing, open2 proteoliposome complex I at 2.6 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 i 1–128（128 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 ZN ZINC ION × 2 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q25 Outward-facing, open1 proteoliposome complex I at 2.8 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 i 1–128（128 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 ZN ZINC ION × 2 MG MAGNESIUM ION × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.80 Å
8Q45 Inward-facing, closed proteoliposome complex I at 2.7 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 i 1–128（128 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 16 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.70 Å
8Q46 Inward-facing, open2 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 i 1–128（128 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q47 Inward-facing, open1 proteoliposome complex I at 2.9 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 i 1–128（128 aa）	非标准单体：是（mmCIF未提供具体位点）	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 15 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 26 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 5 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.90 Å
8Q48 Outward-facing, closed proteoliposome complex I at 2.5 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 i 1–128（128 aa）	非标准单体：是（mmCIF未提供具体位点）	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 35 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.50 Å
8Q49 Outward-facing, open2 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 i 1–128（128 aa）	非标准单体：是（mmCIF未提供具体位点）	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CHD CHOLIC ACID × 1 ZN ZINC ION × 2 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 FVH [[(2~{R},3~{S},4~{R},5~{R})-5-[(3~{R})-3-aminocarbonylpiperidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{R},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3-oxidanyl-4-phosphonooxy-oxolan-2-yl]methyl hydrogen phosphate × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q4A Outward-facing, open1 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 i 1–128（128 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
9SMF Reduced bovine complex I in lipid nanodisc, NADH-active-Q10 提交 2025-09-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 i 2–128（127 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 20 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 8 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.51 Å
9SMG Reduced bovine complex I in lipid nanodisc, NADH-active-altQ10 提交 2025-09-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 i 2–128（127 aa）	非标准单体：是（mmCIF未提供具体位点）	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 18 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.42 Å
9SMH Reduced bovine complex I in lipid nanodisc, NADH-active-DDM 提交 2025-09-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 i 2–128（127 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 17 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 LMT DODECYL-BETA-D-MALTOSIDE × 1 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.61 Å
9SMI Reduced bovine complex I in lipid nanodisc, NADH-deactive 提交 2025-09-08	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 i 2–128（127 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 27 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 LMT DODECYL-BETA-D-MALTOSIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 5 CHD CHOLIC ACID × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.01 Å
9W2U Cryo-EM structure of complex I on the bovine heart submitochondrial particles, open 提交 2025-07-28	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 u 2–128（127 aa）	非标准单体：是（mmCIF未提供具体位点）	FME N-FORMYLMETHIONINE × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 18 CDL CARDIOLIPIN × 6 CHD CHOLIC ACID × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.60 Å
9W2V Cryo-EM structure of complex I on the bovine heart submitochondrial particles, closed 提交 2025-07-28	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 u 2–128（127 aa）	非标准单体：是（mmCIF未提供具体位点）	FME N-FORMYLMETHIONINE × 4 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 19 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 12 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 6 MG MAGNESIUM ION × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.80 Å

共 49 个其他 PDB 条目、49 个 assembly。 打开独立比较页并筛选聚集状态

查看构建体与数据证据

UniProt名称	NDUB6_BOVIN
Isoform	—
PDB实体	35
链与序列区间	作者链 i； PDB构建体 1–33； UniProt 1–33

;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 ;

物种未注明

UniProt P48305

当前结构中的状态

Assembly	聚集状态	构建体	突变与修饰	配体、离子与共同组分	实验方法与环境	结构质量
1	蛋白异源复合物 异源复合物 蛋白 × 45 PDB 声明：45-meric（45） 与蛋白拷贝数一致	链 m； UniProt 33–129	未记录	NADH-ubiquinone oxidoreductase chain 3 × 1 （P03898） NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial × 1 （P42026） NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial × 1 （P23709） NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial × 1 （P17694） NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial × 1 （P04394） NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial × 1 （P25708） ;NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, NDUFS1 ; × 1 （P15690） NADH-ubiquinone oxidoreductase chain 1 × 1 （P03887） NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial × 1 （P42028） NADH-ubiquinone oxidoreductase chain 6 × 1 （P03924） NADH-ubiquinone oxidoreductase chain 4L × 1 （P03902） NADH-ubiquinone oxidoreductase chain 5 × 1 （P03920） NADH-ubiquinone oxidoreductase chain 4 × 1 （P03910） NADH-ubiquinone oxidoreductase chain 2 × 1 （P03892） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, NDUFA10,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial ; × 1 （P34942） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial × 1 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial × 1 ;NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial ; × 1 （P23934） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 × 1 （Q02370） Acyl carrier protein, mitochondrial × 1 （P52505） Acyl carrier protein, mitochondrial × 1 （P52505） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 × 1 （P23935） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 × 1 （Q02366） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 ; × 1 （P42029） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 × 1 （Q8HXG6） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 ; × 1 （Q95KV7） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 × 1 （Q02377） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 ; × 1 （Q02371） NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial × 1 （Q02376） ;NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2 ; × 1 （Q02827） NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 × 1 （Q02379） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 × 1 （Q02378） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial × 1 （Q8HXG5） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial ; × 1 （Q02380） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 ; × 1 （Q02367） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, NDUFB2 × 1 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3, NDUFB3 × 1 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, NDUFB8 × 1 ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 ; × 1 （Q02369） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 × 1 （Q02368） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10, NDUFB10,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10, NDUFB10 ; × 1 （Q02373） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 × 1 （O97725） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7, NDUFA7 × 1 NADH dehydrogenase [ubiquinone] flavoprotein 3, NDUFV3 × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液：pH 8 cryo-EM玻璃化条件：冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 4.35 Å

数据库中的同蛋白其他状态

以下每一行都是同一 UniProt 蛋白在另一个 PDB 条目中的 biological assembly， “相对当前条目”直接指出证据层面的不同；没有差异标签表示当前已读取字段一致。

其他 PDB	相对当前条目 5LC5	Assembly / 聚集状态	构建体	突变与修饰	配体、离子与非聚合物	实验方法与环境	结构质量
5LDW Structure of mammalian respiratory Complex I, class1 提交 2016-06-28	实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 m 33–129（97 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8；20 mM TRIS-HCL, 150 mM NaCl, 0.03% CYMAL-7 cryo-EM玻璃化条件 冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus present in a cold room, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 4.27 Å
5LDX Structure of mammalian respiratory Complex I, class3. 提交 2016-06-28	结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 m 33–129（97 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 20 mM TRIS-HCL, 150 mM NaCl, 0.03% CYMAL-7；pH 8 cryo-EM玻璃化条件 冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 5.60 Å
5O31 Mitochondrial complex I in the deactive state 提交 2017-05-23	构建体不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 m 2–129（128 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.55 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.13 Å
7DGQ Activity optimized supercomplex state1 提交 2020-11-12	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 a 2–129（128 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 CU COPPER (II) ION × 3 HEA HEME-A × 2 MG MAGNESIUM ION × 1 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 UQ2 UBIQUINONE-2 × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 5.00 Å
7DGR Activity optimized supercomplex state2 提交 2020-11-12	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 a 2–129（128 aa）	未记录	FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 3 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.60 Å
7DGS Activity optimized supercomplex state3 提交 2020-11-12	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 a 2–129（128 aa）	未记录	FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 7.80 Å
7DGZ Activity optimized complex I (closed form) 提交 2020-11-12	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 a 2–129（128 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 2 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 3.80 Å
7DH0 Activity optimized complex I (open form) 提交 2020-11-12	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 a 2–129（128 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.20 Å
7DKF Activity optimized supercomplex state4 提交 2020-11-24	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 a2 2–129（128 aa）	未记录	HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 8.30 Å
7QSD Bovine complex I in the active state at 3.1 A 提交 2022-01-13	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 m 1–129（129 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 13 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 CDL CARDIOLIPIN × 4 LMT DODECYL-BETA-D-MALTOSIDE × 3 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 3.10 Å
7QSK Bovine complex I in lipid nanodisc, Active-Q10 提交 2022-01-13	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 m 1–129（129 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 19 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.84 Å
7QSL Bovine complex I in lipid nanodisc, Active-apo 提交 2022-01-13	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 m 1–129（129 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 20 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 8 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.76 Å
7QSM Bovine complex I in lipid nanodisc, Deactive-ligand (composite) 提交 2022-01-13	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 m 1–129（129 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 GOL GLYCEROL × 1 LMT DODECYL-BETA-D-MALTOSIDE × 1 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.30 Å
7QSN Bovine complex I in lipid nanodisc, Deactive-apo 提交 2022-01-13	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 m 1–129（129 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 6 CHD CHOLIC ACID × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.81 Å
7QSO Bovine complex I in lipid nanodisc, State 3 (Slack) 提交 2022-01-13	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 m 1–129（129 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 6 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CHD CHOLIC ACID × 2 CDL CARDIOLIPIN × 6 U10 UBIQUINONE-10 × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 3.02 Å
7R41 Bovine complex I in the presence of IM1761092, active class i (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 m 1–129（129 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 16 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R42 Bovine complex I in the presence of IM1761092, active class ii (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 m 1–129（129 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 17 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R43 Bovine complex I in the presence of IM1761092, active class iii (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 m 1–129（129 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 CDL CARDIOLIPIN × 5 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R44 Bovine complex I in the presence of IM1761092, active class iv (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 m 1–129（129 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 11 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R45 Bovine complex I in the presence of IM1761092, deactive class i (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 m 1–129（129 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R46 Bovine complex I in the presence of IM1761092, deactive class ii (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 m 1–129（129 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 11 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R47 Bovine complex I in the presence of IM1761092, deactive class iii (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 m 1–129（129 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R48 Bovine complex I in the presence of IM1761092, deactive class iv (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 m 1–129（129 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 15 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 13 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4C Bovine complex I in the presence of IM1761092, deactive class v (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 m 1–129（129 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 12 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4D Bovine complex I in the presence of IM1761092, deactive class vi (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 m 1–129（129 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4F Bovine complex I in the presence of IM1761092, slack class i (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 m 1–129（129 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 7 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 3 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 CDL CARDIOLIPIN × 6 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R4G Bovine complex I in the presence of IM1761092, slack class ii (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 m 1–129（129 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 LMT DODECYL-BETA-D-MALTOSIDE × 10 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.50 Å
8Q0A Inward-facing, closed proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 m 1–129（129 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 16 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 8 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 MG MAGNESIUM ION × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0F Inward-facing, open2 proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 m 1–129（129 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 21 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0J Inward-facing, slack proteoliposome complex I at 3.8 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 m 1–129（129 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 4 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.80 Å
8Q0M Outward-facing, closed proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 m 1–129（129 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0O Outward-facing, open2 proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 m 1–129（129 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0Q Outward-facing, slack proteoliposome complex I at 3.6 A. Initially purified in DDM 提交 2023-07-28	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 m 1–129（129 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 4 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.60 Å
8Q1P Inward-facing, open2 proteoliposome complex I at 2.9 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 m 1–129（129 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.90 Å
8Q1U Inward-facing, open1 proteoliposome complex I at 3.3 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 m 1–129（129 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 15 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 5 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.30 Å
8Q1Y Outward-facing, open2 proteoliposome complex I at 2.6 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 m 1–129（129 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 ZN ZINC ION × 2 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q25 Outward-facing, open1 proteoliposome complex I at 2.8 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 m 1–129（129 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 ZN ZINC ION × 2 MG MAGNESIUM ION × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.80 Å
8Q45 Inward-facing, closed proteoliposome complex I at 2.7 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 m 1–129（129 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 16 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.70 Å
8Q46 Inward-facing, open2 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 m 1–129（129 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q47 Inward-facing, open1 proteoliposome complex I at 2.9 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 m 1–129（129 aa）	非标准单体：是（mmCIF未提供具体位点）	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 15 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 26 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 5 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.90 Å
8Q48 Outward-facing, closed proteoliposome complex I at 2.5 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 m 1–129（129 aa）	非标准单体：是（mmCIF未提供具体位点）	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 35 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.50 Å
8Q49 Outward-facing, open2 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 m 1–129（129 aa）	非标准单体：是（mmCIF未提供具体位点）	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CHD CHOLIC ACID × 1 ZN ZINC ION × 2 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 FVH [[(2~{R},3~{S},4~{R},5~{R})-5-[(3~{R})-3-aminocarbonylpiperidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{R},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3-oxidanyl-4-phosphonooxy-oxolan-2-yl]methyl hydrogen phosphate × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q4A Outward-facing, open1 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 m 1–129（129 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
9SMF Reduced bovine complex I in lipid nanodisc, NADH-active-Q10 提交 2025-09-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 m 1–129（129 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 20 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 8 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.51 Å
9SMG Reduced bovine complex I in lipid nanodisc, NADH-active-altQ10 提交 2025-09-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 m 1–129（129 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 18 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.42 Å
9SMH Reduced bovine complex I in lipid nanodisc, NADH-active-DDM 提交 2025-09-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 m 1–129（129 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 17 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 LMT DODECYL-BETA-D-MALTOSIDE × 1 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.61 Å
9SMI Reduced bovine complex I in lipid nanodisc, NADH-deactive 提交 2025-09-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 m 1–129（129 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 27 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 LMT DODECYL-BETA-D-MALTOSIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 5 CHD CHOLIC ACID × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.01 Å
9W2U Cryo-EM structure of complex I on the bovine heart submitochondrial particles, open 提交 2025-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 m 2–129（128 aa）	未记录	FME N-FORMYLMETHIONINE × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 18 CDL CARDIOLIPIN × 6 CHD CHOLIC ACID × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.60 Å
9W2V Cryo-EM structure of complex I on the bovine heart submitochondrial particles, closed 提交 2025-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 m 2–129（128 aa）	未记录	FME N-FORMYLMETHIONINE × 4 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 19 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 12 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 6 MG MAGNESIUM ION × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.80 Å

共 49 个其他 PDB 条目、49 个 assembly。 打开独立比较页并筛选聚集状态

查看构建体与数据证据

UniProt名称	NDUB4_BOVIN
Isoform	—
PDB实体	39
链与序列区间	作者链 m； PDB构建体 22–118； UniProt 33–129

;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 ;

物种未注明

UniProt Q02369

当前结构中的状态

Assembly	聚集状态	构建体	突变与修饰	配体、离子与共同组分	实验方法与环境	结构质量
1	蛋白异源复合物 异源复合物 蛋白 × 45 PDB 声明：45-meric（45） 与蛋白拷贝数一致	链 n； UniProt 11–137	未记录	NADH-ubiquinone oxidoreductase chain 3 × 1 （P03898） NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial × 1 （P42026） NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial × 1 （P23709） NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial × 1 （P17694） NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial × 1 （P04394） NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial × 1 （P25708） ;NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, NDUFS1 ; × 1 （P15690） NADH-ubiquinone oxidoreductase chain 1 × 1 （P03887） NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial × 1 （P42028） NADH-ubiquinone oxidoreductase chain 6 × 1 （P03924） NADH-ubiquinone oxidoreductase chain 4L × 1 （P03902） NADH-ubiquinone oxidoreductase chain 5 × 1 （P03920） NADH-ubiquinone oxidoreductase chain 4 × 1 （P03910） NADH-ubiquinone oxidoreductase chain 2 × 1 （P03892） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, NDUFA10,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial ; × 1 （P34942） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial × 1 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial × 1 ;NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial ; × 1 （P23934） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 × 1 （Q02370） Acyl carrier protein, mitochondrial × 1 （P52505） Acyl carrier protein, mitochondrial × 1 （P52505） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 × 1 （P23935） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 × 1 （Q02366） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 ; × 1 （P42029） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 × 1 （Q8HXG6） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 ; × 1 （Q95KV7） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 × 1 （Q02377） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 ; × 1 （Q02371） NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial × 1 （Q02376） ;NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2 ; × 1 （Q02827） NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 × 1 （Q02379） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 × 1 （Q02378） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial × 1 （Q8HXG5） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial ; × 1 （Q02380） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 ; × 1 （Q02367） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, NDUFB2 × 1 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3, NDUFB3 × 1 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, NDUFB8 × 1 ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 ; × 1 （P48305） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 × 1 （Q02368） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10, NDUFB10,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10, NDUFB10 ; × 1 （Q02373） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 × 1 （O97725） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7, NDUFA7 × 1 NADH dehydrogenase [ubiquinone] flavoprotein 3, NDUFV3 × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液：pH 8 cryo-EM玻璃化条件：冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 4.35 Å

数据库中的同蛋白其他状态

以下每一行都是同一 UniProt 蛋白在另一个 PDB 条目中的 biological assembly， “相对当前条目”直接指出证据层面的不同；没有差异标签表示当前已读取字段一致。

其他 PDB	相对当前条目 5LC5	Assembly / 聚集状态	构建体	突变与修饰	配体、离子与非聚合物	实验方法与环境	结构质量
5LDW Structure of mammalian respiratory Complex I, class1 提交 2016-06-28	实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 n 11–137（127 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8；20 mM TRIS-HCL, 150 mM NaCl, 0.03% CYMAL-7 cryo-EM玻璃化条件 冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus present in a cold room, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 4.27 Å
5LDX Structure of mammalian respiratory Complex I, class3. 提交 2016-06-28	结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 n 11–137（127 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 20 mM TRIS-HCL, 150 mM NaCl, 0.03% CYMAL-7；pH 8 cryo-EM玻璃化条件 冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 5.60 Å
5O31 Mitochondrial complex I in the deactive state 提交 2017-05-23	构建体不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 n 2–179（178 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.55 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.13 Å
7DGQ Activity optimized supercomplex state1 提交 2020-11-12	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 f 2–179（178 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 CU COPPER (II) ION × 3 HEA HEME-A × 2 MG MAGNESIUM ION × 1 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 UQ2 UBIQUINONE-2 × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 5.00 Å
7DGR Activity optimized supercomplex state2 提交 2020-11-12	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 f 2–179（178 aa）	未记录	FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 3 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.60 Å
7DGS Activity optimized supercomplex state3 提交 2020-11-12	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 f 2–179（178 aa）	未记录	FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 7.80 Å
7DGZ Activity optimized complex I (closed form) 提交 2020-11-12	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 f 2–179（178 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 2 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 3.80 Å
7DH0 Activity optimized complex I (open form) 提交 2020-11-12	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 f 2–179（178 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.20 Å
7DKF Activity optimized supercomplex state4 提交 2020-11-24	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 f2 2–179（178 aa）	未记录	HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 8.30 Å
7QSD Bovine complex I in the active state at 3.1 A 提交 2022-01-13	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 n 1–179（179 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 13 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 CDL CARDIOLIPIN × 4 LMT DODECYL-BETA-D-MALTOSIDE × 3 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 3.10 Å
7QSK Bovine complex I in lipid nanodisc, Active-Q10 提交 2022-01-13	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 n 1–179（179 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 19 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.84 Å
7QSL Bovine complex I in lipid nanodisc, Active-apo 提交 2022-01-13	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 n 1–179（179 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 20 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 8 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.76 Å
7QSM Bovine complex I in lipid nanodisc, Deactive-ligand (composite) 提交 2022-01-13	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 n 1–179（179 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 GOL GLYCEROL × 1 LMT DODECYL-BETA-D-MALTOSIDE × 1 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.30 Å
7QSN Bovine complex I in lipid nanodisc, Deactive-apo 提交 2022-01-13	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 n 1–179（179 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 6 CHD CHOLIC ACID × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.81 Å
7QSO Bovine complex I in lipid nanodisc, State 3 (Slack) 提交 2022-01-13	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 n 1–179（179 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 6 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CHD CHOLIC ACID × 2 CDL CARDIOLIPIN × 6 U10 UBIQUINONE-10 × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 3.02 Å
7R41 Bovine complex I in the presence of IM1761092, active class i (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 n 1–179（179 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 16 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R42 Bovine complex I in the presence of IM1761092, active class ii (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 n 1–179（179 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 17 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R43 Bovine complex I in the presence of IM1761092, active class iii (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 n 1–179（179 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 CDL CARDIOLIPIN × 5 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R44 Bovine complex I in the presence of IM1761092, active class iv (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 n 1–179（179 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 11 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R45 Bovine complex I in the presence of IM1761092, deactive class i (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 n 1–179（179 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R46 Bovine complex I in the presence of IM1761092, deactive class ii (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 n 1–179（179 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 11 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R47 Bovine complex I in the presence of IM1761092, deactive class iii (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 n 1–179（179 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R48 Bovine complex I in the presence of IM1761092, deactive class iv (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 n 1–179（179 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 15 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 13 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4C Bovine complex I in the presence of IM1761092, deactive class v (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 n 1–179（179 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 12 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4D Bovine complex I in the presence of IM1761092, deactive class vi (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 n 1–179（179 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4F Bovine complex I in the presence of IM1761092, slack class i (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 n 1–179（179 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 7 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 3 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 CDL CARDIOLIPIN × 6 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R4G Bovine complex I in the presence of IM1761092, slack class ii (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 n 1–179（179 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 LMT DODECYL-BETA-D-MALTOSIDE × 10 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.50 Å
8Q0A Inward-facing, closed proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 n 1–179（179 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 16 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 8 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 MG MAGNESIUM ION × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0F Inward-facing, open2 proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 n 1–179（179 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 21 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0J Inward-facing, slack proteoliposome complex I at 3.8 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 n 1–179（179 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 4 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.80 Å
8Q0M Outward-facing, closed proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 n 1–179（179 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0O Outward-facing, open2 proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 n 1–179（179 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0Q Outward-facing, slack proteoliposome complex I at 3.6 A. Initially purified in DDM 提交 2023-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 n 1–179（179 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 4 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.60 Å
8Q1P Inward-facing, open2 proteoliposome complex I at 2.9 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 n 1–179（179 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.90 Å
8Q1U Inward-facing, open1 proteoliposome complex I at 3.3 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 n 1–179（179 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 15 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 5 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.30 Å
8Q1Y Outward-facing, open2 proteoliposome complex I at 2.6 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 n 1–179（179 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 ZN ZINC ION × 2 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q25 Outward-facing, open1 proteoliposome complex I at 2.8 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 n 1–179（179 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 ZN ZINC ION × 2 MG MAGNESIUM ION × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.80 Å
8Q45 Inward-facing, closed proteoliposome complex I at 2.7 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 n 1–179（179 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 16 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.70 Å
8Q46 Inward-facing, open2 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 n 1–179（179 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q47 Inward-facing, open1 proteoliposome complex I at 2.9 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 n 1–179（179 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 15 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 26 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 5 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.90 Å
8Q48 Outward-facing, closed proteoliposome complex I at 2.5 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 n 1–179（179 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 35 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.50 Å
8Q49 Outward-facing, open2 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 n 1–179（179 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CHD CHOLIC ACID × 1 ZN ZINC ION × 2 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 FVH [[(2~{R},3~{S},4~{R},5~{R})-5-[(3~{R})-3-aminocarbonylpiperidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{R},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3-oxidanyl-4-phosphonooxy-oxolan-2-yl]methyl hydrogen phosphate × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q4A Outward-facing, open1 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 n 1–179（179 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
9SMF Reduced bovine complex I in lipid nanodisc, NADH-active-Q10 提交 2025-09-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 n 1–179（179 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 20 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 8 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.51 Å
9SMG Reduced bovine complex I in lipid nanodisc, NADH-active-altQ10 提交 2025-09-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 n 1–179（179 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 18 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.42 Å
9SMH Reduced bovine complex I in lipid nanodisc, NADH-active-DDM 提交 2025-09-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 n 1–179（179 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 17 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 LMT DODECYL-BETA-D-MALTOSIDE × 1 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.61 Å
9SMI Reduced bovine complex I in lipid nanodisc, NADH-deactive 提交 2025-09-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 n 1–179（179 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 27 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 LMT DODECYL-BETA-D-MALTOSIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 5 CHD CHOLIC ACID × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.01 Å
9W2U Cryo-EM structure of complex I on the bovine heart submitochondrial particles, open 提交 2025-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 n 8–179（172 aa）	未记录	FME N-FORMYLMETHIONINE × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 18 CDL CARDIOLIPIN × 6 CHD CHOLIC ACID × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.60 Å
9W2V Cryo-EM structure of complex I on the bovine heart submitochondrial particles, closed 提交 2025-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 n 8–179（172 aa）	未记录	FME N-FORMYLMETHIONINE × 4 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 19 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 12 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 6 MG MAGNESIUM ION × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.80 Å

共 49 个其他 PDB 条目、49 个 assembly。 打开独立比较页并筛选聚集状态

查看构建体与数据证据

UniProt名称	NDUB9_BOVIN
Isoform	—
PDB实体	40
链与序列区间	作者链 n； PDB构建体 1–127； UniProt 11–137

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7

物种未注明

UniProt Q02368

当前结构中的状态

Assembly	聚集状态	构建体	突变与修饰	配体、离子与共同组分	实验方法与环境	结构质量
1	蛋白异源复合物 异源复合物 蛋白 × 45 PDB 声明：45-meric（45） 与蛋白拷贝数一致	链 o； UniProt 58–115	未记录	NADH-ubiquinone oxidoreductase chain 3 × 1 （P03898） NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial × 1 （P42026） NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial × 1 （P23709） NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial × 1 （P17694） NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial × 1 （P04394） NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial × 1 （P25708） ;NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, NDUFS1 ; × 1 （P15690） NADH-ubiquinone oxidoreductase chain 1 × 1 （P03887） NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial × 1 （P42028） NADH-ubiquinone oxidoreductase chain 6 × 1 （P03924） NADH-ubiquinone oxidoreductase chain 4L × 1 （P03902） NADH-ubiquinone oxidoreductase chain 5 × 1 （P03920） NADH-ubiquinone oxidoreductase chain 4 × 1 （P03910） NADH-ubiquinone oxidoreductase chain 2 × 1 （P03892） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, NDUFA10,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial ; × 1 （P34942） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial × 1 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial × 1 ;NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial ; × 1 （P23934） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 × 1 （Q02370） Acyl carrier protein, mitochondrial × 1 （P52505） Acyl carrier protein, mitochondrial × 1 （P52505） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 × 1 （P23935） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 × 1 （Q02366） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 ; × 1 （P42029） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 × 1 （Q8HXG6） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 ; × 1 （Q95KV7） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 × 1 （Q02377） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 ; × 1 （Q02371） NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial × 1 （Q02376） ;NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2 ; × 1 （Q02827） NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 × 1 （Q02379） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 × 1 （Q02378） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial × 1 （Q8HXG5） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial ; × 1 （Q02380） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 ; × 1 （Q02367） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, NDUFB2 × 1 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3, NDUFB3 × 1 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, NDUFB8 × 1 ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 ; × 1 （P48305） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 ; × 1 （Q02369） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10, NDUFB10,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10, NDUFB10 ; × 1 （Q02373） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 × 1 （O97725） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7, NDUFA7 × 1 NADH dehydrogenase [ubiquinone] flavoprotein 3, NDUFV3 × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液：pH 8 cryo-EM玻璃化条件：冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 4.35 Å

数据库中的同蛋白其他状态

以下每一行都是同一 UniProt 蛋白在另一个 PDB 条目中的 biological assembly， “相对当前条目”直接指出证据层面的不同；没有差异标签表示当前已读取字段一致。

其他 PDB	相对当前条目 5LC5	Assembly / 聚集状态	构建体	突变与修饰	配体、离子与非聚合物	实验方法与环境	结构质量
5LDW Structure of mammalian respiratory Complex I, class1 提交 2016-06-28	构建体不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 o 2–137（136 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8；20 mM TRIS-HCL, 150 mM NaCl, 0.03% CYMAL-7 cryo-EM玻璃化条件 冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus present in a cold room, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 4.27 Å
5LDX Structure of mammalian respiratory Complex I, class3. 提交 2016-06-28	结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 o 58–115（58 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 20 mM TRIS-HCL, 150 mM NaCl, 0.03% CYMAL-7；pH 8 cryo-EM玻璃化条件 冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 5.60 Å
5O31 Mitochondrial complex I in the deactive state 提交 2017-05-23	构建体不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 o 2–137（136 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.55 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.13 Å
7DGQ Activity optimized supercomplex state1 提交 2020-11-12	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 d 2–118（117 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 CU COPPER (II) ION × 3 HEA HEME-A × 2 MG MAGNESIUM ION × 1 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 UQ2 UBIQUINONE-2 × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 5.00 Å
7DGR Activity optimized supercomplex state2 提交 2020-11-12	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 d 2–118（117 aa）	未记录	FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 3 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.60 Å
7DGS Activity optimized supercomplex state3 提交 2020-11-12	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 d 2–118（117 aa）	未记录	FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 7.80 Å
7DGZ Activity optimized complex I (closed form) 提交 2020-11-12	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 d 2–137（136 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 2 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 3.80 Å
7DH0 Activity optimized complex I (open form) 提交 2020-11-12	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 d 2–137（136 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.20 Å
7DKF Activity optimized supercomplex state4 提交 2020-11-24	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 d2 2–137（136 aa）	未记录	HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 8.30 Å
7QSD Bovine complex I in the active state at 3.1 A 提交 2022-01-13	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 o 1–137（137 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 13 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 CDL CARDIOLIPIN × 4 LMT DODECYL-BETA-D-MALTOSIDE × 3 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 3.10 Å
7QSK Bovine complex I in lipid nanodisc, Active-Q10 提交 2022-01-13	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 o 1–137（137 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 19 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.84 Å
7QSL Bovine complex I in lipid nanodisc, Active-apo 提交 2022-01-13	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 o 1–137（137 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 20 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 8 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.76 Å
7QSM Bovine complex I in lipid nanodisc, Deactive-ligand (composite) 提交 2022-01-13	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 o 1–137（137 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 GOL GLYCEROL × 1 LMT DODECYL-BETA-D-MALTOSIDE × 1 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.30 Å
7QSN Bovine complex I in lipid nanodisc, Deactive-apo 提交 2022-01-13	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 o 1–137（137 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 6 CHD CHOLIC ACID × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.81 Å
7QSO Bovine complex I in lipid nanodisc, State 3 (Slack) 提交 2022-01-13	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 o 1–137（137 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 6 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CHD CHOLIC ACID × 2 CDL CARDIOLIPIN × 6 U10 UBIQUINONE-10 × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 3.02 Å
7R41 Bovine complex I in the presence of IM1761092, active class i (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 o 1–137（137 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 16 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R42 Bovine complex I in the presence of IM1761092, active class ii (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 o 1–137（137 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 17 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R43 Bovine complex I in the presence of IM1761092, active class iii (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 o 1–137（137 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 CDL CARDIOLIPIN × 5 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R44 Bovine complex I in the presence of IM1761092, active class iv (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 o 1–137（137 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 11 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R45 Bovine complex I in the presence of IM1761092, deactive class i (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 o 1–137（137 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R46 Bovine complex I in the presence of IM1761092, deactive class ii (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 o 1–137（137 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 11 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R47 Bovine complex I in the presence of IM1761092, deactive class iii (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 o 1–137（137 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R48 Bovine complex I in the presence of IM1761092, deactive class iv (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 o 2–137（136 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 15 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 13 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4C Bovine complex I in the presence of IM1761092, deactive class v (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 o 1–137（137 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 12 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4D Bovine complex I in the presence of IM1761092, deactive class vi (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 o 1–137（137 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4F Bovine complex I in the presence of IM1761092, slack class i (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 o 1–137（137 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 7 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 3 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 CDL CARDIOLIPIN × 6 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R4G Bovine complex I in the presence of IM1761092, slack class ii (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 o 1–137（137 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 LMT DODECYL-BETA-D-MALTOSIDE × 10 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.50 Å
8Q0A Inward-facing, closed proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 o 1–137（137 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 16 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 8 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 MG MAGNESIUM ION × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0F Inward-facing, open2 proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 o 1–137（137 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 21 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0J Inward-facing, slack proteoliposome complex I at 3.8 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 o 1–137（137 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 4 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.80 Å
8Q0M Outward-facing, closed proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 o 1–137（137 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0O Outward-facing, open2 proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 o 1–137（137 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0Q Outward-facing, slack proteoliposome complex I at 3.6 A. Initially purified in DDM 提交 2023-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 o 1–137（137 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 4 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.60 Å
8Q1P Inward-facing, open2 proteoliposome complex I at 2.9 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 o 1–137（137 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.90 Å
8Q1U Inward-facing, open1 proteoliposome complex I at 3.3 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 o 1–137（137 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 15 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 5 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.30 Å
8Q1Y Outward-facing, open2 proteoliposome complex I at 2.6 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 o 1–137（137 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 ZN ZINC ION × 2 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q25 Outward-facing, open1 proteoliposome complex I at 2.8 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 o 1–137（137 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 ZN ZINC ION × 2 MG MAGNESIUM ION × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.80 Å
8Q45 Inward-facing, closed proteoliposome complex I at 2.7 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 o 1–137（137 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 16 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.70 Å
8Q46 Inward-facing, open2 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 o 1–137（137 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q47 Inward-facing, open1 proteoliposome complex I at 2.9 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 o 1–137（137 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 15 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 26 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 5 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.90 Å
8Q48 Outward-facing, closed proteoliposome complex I at 2.5 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 o 1–137（137 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 35 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.50 Å
8Q49 Outward-facing, open2 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 o 1–137（137 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CHD CHOLIC ACID × 1 ZN ZINC ION × 2 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 FVH [[(2~{R},3~{S},4~{R},5~{R})-5-[(3~{R})-3-aminocarbonylpiperidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{R},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3-oxidanyl-4-phosphonooxy-oxolan-2-yl]methyl hydrogen phosphate × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q4A Outward-facing, open1 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 o 1–137（137 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
9SMF Reduced bovine complex I in lipid nanodisc, NADH-active-Q10 提交 2025-09-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 o 1–137（137 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 20 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 8 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.51 Å
9SMG Reduced bovine complex I in lipid nanodisc, NADH-active-altQ10 提交 2025-09-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 o 1–137（137 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 18 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.42 Å
9SMH Reduced bovine complex I in lipid nanodisc, NADH-active-DDM 提交 2025-09-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 o 1–137（137 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 17 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 LMT DODECYL-BETA-D-MALTOSIDE × 1 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.61 Å
9SMI Reduced bovine complex I in lipid nanodisc, NADH-deactive 提交 2025-09-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 o 1–137（137 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 27 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 LMT DODECYL-BETA-D-MALTOSIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 5 CHD CHOLIC ACID × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.01 Å
9W2U Cryo-EM structure of complex I on the bovine heart submitochondrial particles, open 提交 2025-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 o 2–123（122 aa）	未记录	FME N-FORMYLMETHIONINE × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 18 CDL CARDIOLIPIN × 6 CHD CHOLIC ACID × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.60 Å
9W2V Cryo-EM structure of complex I on the bovine heart submitochondrial particles, closed 提交 2025-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 o 2–123（122 aa）	未记录	FME N-FORMYLMETHIONINE × 4 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 19 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 12 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 6 MG MAGNESIUM ION × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.80 Å

共 49 个其他 PDB 条目、49 个 assembly。 打开独立比较页并筛选聚集状态

查看构建体与数据证据

UniProt名称	NDUB7_BOVIN
Isoform	—
PDB实体	41
链与序列区间	作者链 o； PDB构建体 1–58； UniProt 58–115

;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10, NDUFB10,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10, NDUFB10 ;

物种未注明

UniProt Q02373

当前结构中的状态

Assembly	聚集状态	构建体	突变与修饰	配体、离子与共同组分	实验方法与环境	结构质量
1	蛋白异源复合物 异源复合物 蛋白 × 45 PDB 声明：45-meric（45） 与蛋白拷贝数一致	链 p； UniProt 77–143	未记录	NADH-ubiquinone oxidoreductase chain 3 × 1 （P03898） NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial × 1 （P42026） NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial × 1 （P23709） NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial × 1 （P17694） NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial × 1 （P04394） NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial × 1 （P25708） ;NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, NDUFS1 ; × 1 （P15690） NADH-ubiquinone oxidoreductase chain 1 × 1 （P03887） NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial × 1 （P42028） NADH-ubiquinone oxidoreductase chain 6 × 1 （P03924） NADH-ubiquinone oxidoreductase chain 4L × 1 （P03902） NADH-ubiquinone oxidoreductase chain 5 × 1 （P03920） NADH-ubiquinone oxidoreductase chain 4 × 1 （P03910） NADH-ubiquinone oxidoreductase chain 2 × 1 （P03892） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, NDUFA10,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial ; × 1 （P34942） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial × 1 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial × 1 ;NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial ; × 1 （P23934） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 × 1 （Q02370） Acyl carrier protein, mitochondrial × 1 （P52505） Acyl carrier protein, mitochondrial × 1 （P52505） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 × 1 （P23935） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 × 1 （Q02366） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 ; × 1 （P42029） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 × 1 （Q8HXG6） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 ; × 1 （Q95KV7） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 × 1 （Q02377） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 ; × 1 （Q02371） NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial × 1 （Q02376） ;NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2 ; × 1 （Q02827） NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 × 1 （Q02379） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 × 1 （Q02378） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial × 1 （Q8HXG5） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial ; × 1 （Q02380） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 ; × 1 （Q02367） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, NDUFB2 × 1 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3, NDUFB3 × 1 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, NDUFB8 × 1 ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 ; × 1 （P48305） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 ; × 1 （Q02369） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 × 1 （Q02368） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 × 1 （O97725） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7, NDUFA7 × 1 NADH dehydrogenase [ubiquinone] flavoprotein 3, NDUFV3 × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液：pH 8 cryo-EM玻璃化条件：冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 4.35 Å

数据库中的同蛋白其他状态

以下每一行都是同一 UniProt 蛋白在另一个 PDB 条目中的 biological assembly， “相对当前条目”直接指出证据层面的不同；没有差异标签表示当前已读取字段一致。

其他 PDB	相对当前条目 5LC5	Assembly / 聚集状态	构建体	突变与修饰	配体、离子与非聚合物	实验方法与环境	结构质量
5LDW Structure of mammalian respiratory Complex I, class1 提交 2016-06-28	实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 p 77–143（67 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8；20 mM TRIS-HCL, 150 mM NaCl, 0.03% CYMAL-7 cryo-EM玻璃化条件 冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus present in a cold room, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 4.27 Å
5LDX Structure of mammalian respiratory Complex I, class3. 提交 2016-06-28	结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 p 77–143（67 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 20 mM TRIS-HCL, 150 mM NaCl, 0.03% CYMAL-7；pH 8 cryo-EM玻璃化条件 冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 5.60 Å
5O31 Mitochondrial complex I in the deactive state 提交 2017-05-23	实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 p 77–143（67 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.55 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.13 Å
7DGQ Activity optimized supercomplex state1 提交 2020-11-12	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 g 1–176（176 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 CU COPPER (II) ION × 3 HEA HEME-A × 2 MG MAGNESIUM ION × 1 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 UQ2 UBIQUINONE-2 × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 5.00 Å
7DGR Activity optimized supercomplex state2 提交 2020-11-12	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 g 1–176（176 aa）	未记录	FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 3 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.60 Å
7DGS Activity optimized supercomplex state3 提交 2020-11-12	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 g 1–176（176 aa）	未记录	FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 7.80 Å
7DGZ Activity optimized complex I (closed form) 提交 2020-11-12	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 g 1–176（176 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 2 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 3.80 Å
7DH0 Activity optimized complex I (open form) 提交 2020-11-12	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 g 1–176（176 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.20 Å
7DKF Activity optimized supercomplex state4 提交 2020-11-24	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 g2 1–176（176 aa）	未记录	HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 8.30 Å
7QSD Bovine complex I in the active state at 3.1 A 提交 2022-01-13	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 p 1–176（176 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 13 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 CDL CARDIOLIPIN × 4 LMT DODECYL-BETA-D-MALTOSIDE × 3 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 3.10 Å
7QSK Bovine complex I in lipid nanodisc, Active-Q10 提交 2022-01-13	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 p 1–176（176 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 19 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.84 Å
7QSL Bovine complex I in lipid nanodisc, Active-apo 提交 2022-01-13	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 p 1–176（176 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 20 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 8 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.76 Å
7QSM Bovine complex I in lipid nanodisc, Deactive-ligand (composite) 提交 2022-01-13	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 p 1–176（176 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 GOL GLYCEROL × 1 LMT DODECYL-BETA-D-MALTOSIDE × 1 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.30 Å
7QSN Bovine complex I in lipid nanodisc, Deactive-apo 提交 2022-01-13	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 p 1–176（176 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 6 CHD CHOLIC ACID × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.81 Å
7QSO Bovine complex I in lipid nanodisc, State 3 (Slack) 提交 2022-01-13	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 p 1–176（176 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 6 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CHD CHOLIC ACID × 2 CDL CARDIOLIPIN × 6 U10 UBIQUINONE-10 × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 3.02 Å
7R41 Bovine complex I in the presence of IM1761092, active class i (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 p 1–176（176 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 16 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R42 Bovine complex I in the presence of IM1761092, active class ii (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 p 1–176（176 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 17 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R43 Bovine complex I in the presence of IM1761092, active class iii (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 p 1–176（176 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 CDL CARDIOLIPIN × 5 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R44 Bovine complex I in the presence of IM1761092, active class iv (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 p 1–176（176 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 11 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R45 Bovine complex I in the presence of IM1761092, deactive class i (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 p 1–176（176 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R46 Bovine complex I in the presence of IM1761092, deactive class ii (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 p 1–176（176 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 11 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R47 Bovine complex I in the presence of IM1761092, deactive class iii (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 p 1–176（176 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R48 Bovine complex I in the presence of IM1761092, deactive class iv (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 p 1–176（176 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 15 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 13 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4C Bovine complex I in the presence of IM1761092, deactive class v (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 p 1–176（176 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 12 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4D Bovine complex I in the presence of IM1761092, deactive class vi (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 p 1–176（176 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4F Bovine complex I in the presence of IM1761092, slack class i (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 p 1–176（176 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 7 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 3 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 CDL CARDIOLIPIN × 6 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R4G Bovine complex I in the presence of IM1761092, slack class ii (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 p 1–176（176 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 LMT DODECYL-BETA-D-MALTOSIDE × 10 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.50 Å
8Q0A Inward-facing, closed proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 p 1–176（176 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 16 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 8 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 MG MAGNESIUM ION × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0F Inward-facing, open2 proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 p 1–176（176 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 21 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0J Inward-facing, slack proteoliposome complex I at 3.8 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 p 1–176（176 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 4 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.80 Å
8Q0M Outward-facing, closed proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 p 1–176（176 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0O Outward-facing, open2 proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 p 1–176（176 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0Q Outward-facing, slack proteoliposome complex I at 3.6 A. Initially purified in DDM 提交 2023-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 p 1–176（176 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 4 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.60 Å
8Q1P Inward-facing, open2 proteoliposome complex I at 2.9 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 p 1–176（176 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.90 Å
8Q1U Inward-facing, open1 proteoliposome complex I at 3.3 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 p 1–176（176 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 15 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 5 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.30 Å
8Q1Y Outward-facing, open2 proteoliposome complex I at 2.6 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 p 1–176（176 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 ZN ZINC ION × 2 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q25 Outward-facing, open1 proteoliposome complex I at 2.8 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 p 1–176（176 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 ZN ZINC ION × 2 MG MAGNESIUM ION × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.80 Å
8Q45 Inward-facing, closed proteoliposome complex I at 2.7 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 p 1–176（176 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 16 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.70 Å
8Q46 Inward-facing, open2 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 p 1–176（176 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q47 Inward-facing, open1 proteoliposome complex I at 2.9 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 p 1–176（176 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 15 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 26 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 5 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.90 Å
8Q48 Outward-facing, closed proteoliposome complex I at 2.5 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 p 1–176（176 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 35 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.50 Å
8Q49 Outward-facing, open2 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 p 1–176（176 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CHD CHOLIC ACID × 1 ZN ZINC ION × 2 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 FVH [[(2~{R},3~{S},4~{R},5~{R})-5-[(3~{R})-3-aminocarbonylpiperidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{R},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3-oxidanyl-4-phosphonooxy-oxolan-2-yl]methyl hydrogen phosphate × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q4A Outward-facing, open1 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 p 1–176（176 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
9SMF Reduced bovine complex I in lipid nanodisc, NADH-active-Q10 提交 2025-09-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 p 1–176（176 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 20 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 8 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.51 Å
9SMG Reduced bovine complex I in lipid nanodisc, NADH-active-altQ10 提交 2025-09-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 p 1–176（176 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 18 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.42 Å
9SMH Reduced bovine complex I in lipid nanodisc, NADH-active-DDM 提交 2025-09-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 p 1–176（176 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 17 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 LMT DODECYL-BETA-D-MALTOSIDE × 1 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.61 Å
9SMI Reduced bovine complex I in lipid nanodisc, NADH-deactive 提交 2025-09-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 p 1–176（176 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 27 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 LMT DODECYL-BETA-D-MALTOSIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 5 CHD CHOLIC ACID × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.01 Å
9W2U Cryo-EM structure of complex I on the bovine heart submitochondrial particles, open 提交 2025-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 p 3–175（173 aa）	未记录	FME N-FORMYLMETHIONINE × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 18 CDL CARDIOLIPIN × 6 CHD CHOLIC ACID × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.60 Å
9W2V Cryo-EM structure of complex I on the bovine heart submitochondrial particles, closed 提交 2025-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 p 3–175（173 aa）	未记录	FME N-FORMYLMETHIONINE × 4 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 19 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 12 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 6 MG MAGNESIUM ION × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.80 Å

共 49 个其他 PDB 条目、49 个 assembly。 打开独立比较页并筛选聚集状态

查看构建体与数据证据

UniProt名称	NDUBA_BOVIN
Isoform	—
PDB实体	42
链与序列区间	作者链 p； PDB构建体 73–139； UniProt 77–143

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12

物种未注明

UniProt O97725

当前结构中的状态

Assembly	聚集状态	构建体	突变与修饰	配体、离子与共同组分	实验方法与环境	结构质量
1	蛋白异源复合物 异源复合物 蛋白 × 45 PDB 声明：45-meric（45） 与蛋白拷贝数一致	链 q； UniProt 2–139	未记录	NADH-ubiquinone oxidoreductase chain 3 × 1 （P03898） NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial × 1 （P42026） NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial × 1 （P23709） NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial × 1 （P17694） NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial × 1 （P04394） NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial × 1 （P25708） ;NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, NDUFS1 ; × 1 （P15690） NADH-ubiquinone oxidoreductase chain 1 × 1 （P03887） NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial × 1 （P42028） NADH-ubiquinone oxidoreductase chain 6 × 1 （P03924） NADH-ubiquinone oxidoreductase chain 4L × 1 （P03902） NADH-ubiquinone oxidoreductase chain 5 × 1 （P03920） NADH-ubiquinone oxidoreductase chain 4 × 1 （P03910） NADH-ubiquinone oxidoreductase chain 2 × 1 （P03892） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, NDUFA10,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial ; × 1 （P34942） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial × 1 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial × 1 ;NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial ; × 1 （P23934） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 × 1 （Q02370） Acyl carrier protein, mitochondrial × 1 （P52505） Acyl carrier protein, mitochondrial × 1 （P52505） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 × 1 （P23935） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 × 1 （Q02366） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 ; × 1 （P42029） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 × 1 （Q8HXG6） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 ; × 1 （Q95KV7） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 × 1 （Q02377） ;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 ; × 1 （Q02371） NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial × 1 （Q02376） ;NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2 ; × 1 （Q02827） NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 × 1 （Q02379） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 × 1 （Q02378） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial × 1 （Q8HXG5） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial ; × 1 （Q02380） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 ; × 1 （Q02367） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, NDUFB2 × 1 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3, NDUFB3 × 1 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, NDUFB8 × 1 ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 ; × 1 （P48305） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 ; × 1 （Q02369） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 × 1 （Q02368） ;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10, NDUFB10,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10, NDUFB10 ; × 1 （Q02373） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7, NDUFA7 × 1 NADH dehydrogenase [ubiquinone] flavoprotein 3, NDUFV3 × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液：pH 8 cryo-EM玻璃化条件：冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 4.35 Å

数据库中的同蛋白其他状态

以下每一行都是同一 UniProt 蛋白在另一个 PDB 条目中的 biological assembly， “相对当前条目”直接指出证据层面的不同；没有差异标签表示当前已读取字段一致。

其他 PDB	相对当前条目 5LC5	Assembly / 聚集状态	构建体	突变与修饰	配体、离子与非聚合物	实验方法与环境	结构质量
5LDW Structure of mammalian respiratory Complex I, class1 提交 2016-06-28	构建体不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 q 1–145（145 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8；20 mM TRIS-HCL, 150 mM NaCl, 0.03% CYMAL-7 cryo-EM玻璃化条件 冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus present in a cold room, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 4.27 Å
5LDX Structure of mammalian respiratory Complex I, class3. 提交 2016-06-28	结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 q 2–139（138 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 20 mM TRIS-HCL, 150 mM NaCl, 0.03% CYMAL-7；pH 8 cryo-EM玻璃化条件 冷冻剂 ETHANE；The specimen was vitrified in an environmental plunge-freeze apparatus, blot for 12-15 seconds after the diameter of the blotted meniscus ceases to spread and plunged.	分辨率 5.60 Å
5O31 Mitochondrial complex I in the deactive state 提交 2017-05-23	构建体不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 q 1–145（145 aa）	未记录	SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.55 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.13 Å
7DGQ Activity optimized supercomplex state1 提交 2020-11-12	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 U 1–145（145 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 CU COPPER (II) ION × 3 HEA HEME-A × 2 MG MAGNESIUM ION × 1 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 UQ2 UBIQUINONE-2 × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 5.00 Å
7DGR Activity optimized supercomplex state2 提交 2020-11-12	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 U 1–145（145 aa）	未记录	FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 3 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.60 Å
7DGS Activity optimized supercomplex state3 提交 2020-11-12	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 U 1–145（145 aa）	未记录	FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 7.80 Å
7DGZ Activity optimized complex I (closed form) 提交 2020-11-12	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 U 1–145（145 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 2 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 3.80 Å
7DH0 Activity optimized complex I (open form) 提交 2020-11-12	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 U 1–145（145 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 4.20 Å
7DKF Activity optimized supercomplex state4 提交 2020-11-24	构建体不同 聚集状态不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 80 PDB 声明：80-meric	链 U2 1–145（145 aa）	未记录	HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 8.30 Å
7QSD Bovine complex I in the active state at 3.1 A 提交 2022-01-13	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 q 1–145（145 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 13 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 CDL CARDIOLIPIN × 4 LMT DODECYL-BETA-D-MALTOSIDE × 3 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 3.10 Å
7QSK Bovine complex I in lipid nanodisc, Active-Q10 提交 2022-01-13	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 q 1–145（145 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 19 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.84 Å
7QSL Bovine complex I in lipid nanodisc, Active-apo 提交 2022-01-13	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 q 1–145（145 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 20 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 8 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.76 Å
7QSM Bovine complex I in lipid nanodisc, Deactive-ligand (composite) 提交 2022-01-13	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 q 1–145（145 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 GOL GLYCEROL × 1 LMT DODECYL-BETA-D-MALTOSIDE × 1 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.30 Å
7QSN Bovine complex I in lipid nanodisc, Deactive-apo 提交 2022-01-13	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 q 1–145（145 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 6 CHD CHOLIC ACID × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 2.81 Å
7QSO Bovine complex I in lipid nanodisc, State 3 (Slack) 提交 2022-01-13	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 q 1–145（145 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 6 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CHD CHOLIC ACID × 2 CDL CARDIOLIPIN × 6 U10 UBIQUINONE-10 × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；blot for 10 seconds before plunging	分辨率 3.02 Å
7R41 Bovine complex I in the presence of IM1761092, active class i (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 q 1–145（145 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 16 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R42 Bovine complex I in the presence of IM1761092, active class ii (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 q 1–145（145 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 17 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R43 Bovine complex I in the presence of IM1761092, active class iii (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 q 1–145（145 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 CDL CARDIOLIPIN × 5 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R44 Bovine complex I in the presence of IM1761092, active class iv (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 q 1–145（145 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 11 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R45 Bovine complex I in the presence of IM1761092, deactive class i (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 q 1–145（145 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R46 Bovine complex I in the presence of IM1761092, deactive class ii (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 q 1–145（145 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 11 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 14 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R47 Bovine complex I in the presence of IM1761092, deactive class iii (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 q 1–145（145 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R48 Bovine complex I in the presence of IM1761092, deactive class iv (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 q 1–145（145 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 15 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 13 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4C Bovine complex I in the presence of IM1761092, deactive class v (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 q 1–145（145 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 12 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 12 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4D Bovine complex I in the presence of IM1761092, deactive class vi (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 q 1–145（145 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 13 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 11 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 5 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.30 Å
7R4F Bovine complex I in the presence of IM1761092, slack class i (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 q 1–145（145 aa）	未记录	LMT DODECYL-BETA-D-MALTOSIDE × 7 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 3 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 CDL CARDIOLIPIN × 6 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.40 Å
7R4G Bovine complex I in the presence of IM1761092, slack class ii (Composite map) 提交 2022-02-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 q 1–145（145 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 SF4 IRON/SULFUR CLUSTER × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 LMT DODECYL-BETA-D-MALTOSIDE × 10 I49 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine × 2 CDL CARDIOLIPIN × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.14 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.50 Å
8Q0A Inward-facing, closed proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 q 1–145（145 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 16 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 8 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 MG MAGNESIUM ION × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0F Inward-facing, open2 proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 q 1–145（145 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 21 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0J Inward-facing, slack proteoliposome complex I at 3.8 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 q 1–145（145 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 4 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.80 Å
8Q0M Outward-facing, closed proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 q 1–145（145 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0O Outward-facing, open2 proteoliposome complex I at 3.1 A. Initially purified in DDM. 提交 2023-07-28	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 q 1–145（145 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 28 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.10 Å
8Q0Q Outward-facing, slack proteoliposome complex I at 3.6 A. Initially purified in DDM 提交 2023-07-28	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 q 1–145（145 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 10 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 4 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.60 Å
8Q1P Inward-facing, open2 proteoliposome complex I at 2.9 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 q 1–145（145 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.90 Å
8Q1U Inward-facing, open1 proteoliposome complex I at 3.3 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 q 1–145（145 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 15 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 5 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 3.30 Å
8Q1Y Outward-facing, open2 proteoliposome complex I at 2.6 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 q 1–145（145 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 ZN ZINC ION × 2 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q25 Outward-facing, open1 proteoliposome complex I at 2.8 A, after deactivation treatment. Initially purified in LMNG. 提交 2023-08-01	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 q 1–145（145 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 ZN ZINC ION × 2 MG MAGNESIUM ION × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.80 Å
8Q45 Inward-facing, closed proteoliposome complex I at 2.7 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 q 1–145（145 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 16 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.70 Å
8Q46 Inward-facing, open2 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 q 1–145（145 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 24 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 7 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q47 Inward-facing, open1 proteoliposome complex I at 2.9 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 q 1–145（145 aa）	非标准单体：是（mmCIF未提供具体位点）	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 15 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 26 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 5 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.90 Å
8Q48 Outward-facing, closed proteoliposome complex I at 2.5 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 q 1–145（145 aa）	非标准单体：是（mmCIF未提供具体位点）	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 35 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 9 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.50 Å
8Q49 Outward-facing, open2 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 q 1–145（145 aa）	非标准单体：是（mmCIF未提供具体位点）	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 32 SF4 IRON/SULFUR CLUSTER × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CHD CHOLIC ACID × 1 ZN ZINC ION × 2 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 FVH [[(2~{R},3~{S},4~{R},5~{R})-5-[(3~{R})-3-aminocarbonylpiperidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{R},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3-oxidanyl-4-phosphonooxy-oxolan-2-yl]methyl hydrogen phosphate × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
8Q4A Outward-facing, open1 proteoliposome complex I at 2.6 A. Initially purified in LMNG. 提交 2023-08-05	构建体不同 突变/修饰不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 q 1–145（145 aa）	非标准单体：是（mmCIF未提供具体位点）	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 29 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 17 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 9 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 CDL CARDIOLIPIN × 8 ZN ZINC ION × 2 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Sample was incubated on grid for 30 s before plunge freezing	分辨率 2.60 Å
9SMF Reduced bovine complex I in lipid nanodisc, NADH-active-Q10 提交 2025-09-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 q 1–145（145 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 20 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 U10 UBIQUINONE-10 × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 8 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.51 Å
9SMG Reduced bovine complex I in lipid nanodisc, NADH-active-altQ10 提交 2025-09-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 q 1–145（145 aa）	未记录	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 U10 UBIQUINONE-10 × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 18 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.42 Å
9SMH Reduced bovine complex I in lipid nanodisc, NADH-active-DDM 提交 2025-09-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 q 1–145（145 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 17 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 LMT DODECYL-BETA-D-MALTOSIDE × 1 CDL CARDIOLIPIN × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 CHD CHOLIC ACID × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.61 Å
9SMI Reduced bovine complex I in lipid nanodisc, NADH-deactive 提交 2025-09-08	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 q 1–145（145 aa）	未记录	3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 27 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 7 SF4 IRON/SULFUR CLUSTER × 6 LMT DODECYL-BETA-D-MALTOSIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 5 CHD CHOLIC ACID × 1 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 EHZ ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate × 2 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE；Mix with NADH, then blot for 10 seconds before plunging	分辨率 2.01 Å
9W2U Cryo-EM structure of complex I on the bovine heart submitochondrial particles, open 提交 2025-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 q 1–145（145 aa）	未记录	FME N-FORMYLMETHIONINE × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 18 CDL CARDIOLIPIN × 6 CHD CHOLIC ACID × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.60 Å
9W2V Cryo-EM structure of complex I on the bovine heart submitochondrial particles, closed 提交 2025-07-28	构建体不同 配体/离子不同 实验环境不同 结构质量不同	Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 45 PDB 声明：45-meric	链 q 1–145（145 aa）	未记录	FME N-FORMYLMETHIONINE × 4 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 19 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 12 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 6 MG MAGNESIUM ION × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 冷冻剂 ETHANE	分辨率 2.80 Å

共 49 个其他 PDB 条目、49 个 assembly。 打开独立比较页并筛选聚集状态

查看构建体与数据证据

UniProt名称	NDUAC_BOVIN
Isoform	—
PDB实体	43
链与序列区间	作者链 q； PDB构建体 1–138； UniProt 2–139

页面优先展示蛋白身份、当前 assembly、共同组分、聚集状态和跨 PDB 结构链接。 链映射与序列区间收在“数据证据”中；数据库内部编号、导入时间和 assembly 操作表达式仅用于维护，因此不在读者页面展示。