Angiotensinogen
Homo sapiens
State in the Current Structure
| Assembly | Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Associated Components | Method and Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|
| 1 | Other combination Monomer Protein × 1 其他Polymer 1 PDB declaration: monomeric（1） Consistent with protein copy count | Chain A； UniProt 34–485 | Mutation：N137Q, N271Q, N295Q, C232S, C308S | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 1 | X-RAY DIFFRACTION X-ray crystallization conditions：VAPOR DIFFUSION, SITTING DROP；293.15 K；2.0M Ammonium Sulfate, 0.1M Bicine, pH9.0 | Resolution 2.30 Å R-free 0.189 |
Other States of the Same Protein in the Database
Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.
| Other PDB | Difference from Current Entry 5M3Y | Assembly / Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Non-polymers | Method and Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|---|
| 1N9U Differences and Similarities in Solution Structures of Angiotensin I & II: Implication for Structure-Function Relationship Deposited 2002-11-26 | Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
34–43（10 aa）
|
Not recorded | No recorded non-water small molecule |
SOLUTION NMR
NMR measurement conditions
298 K；Pressure ambient
NMR sample composition
2.5 mM; DMSO-d6 | DMSO-d6
|
Resolution not provided |
| 1N9V Differences and Similarities in Solution Structures of Angiotensin I & II: Implication for Structure-Function Relationship. Deposited 2002-11-26 | Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
34–41（8 aa）
|
Not recorded | No recorded non-water small molecule |
SOLUTION NMR
NMR measurement conditions
298 K；Pressure ambient
NMR sample composition
2.5 mM; DMSO-d6 | DMSO-d6
|
Resolution not provided |
| 2JP8 Angiotensin 1-7 Deposited 2007-04-27 | Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain P
34–40（7 aa）
|
Not recorded | No recorded non-water small molecule |
SOLUTION NMR
NMR measurement conditions
pH 2.9；278 K；Ionic strength (raw mmCIF value) 12；Pressure ambient
NMR sample composition
12.0 mM angiotensin, 95% H2O/5% D2O | 95% H2O/5% D2O
|
Resolution not provided |
| 2WXW Crystal structure of human angiotensinogen Deposited 2009-11-11 | Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
34–485（452 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 8；2-2.5N NACL, 0.2M CACL2, 0.1M TRIS-HCL, PH8
|
Resolution 3.30 Å R-free 0.318 |
| 2X0B Crystal structure of human angiotensinogen complexed with renin Deposited 2009-12-08 | Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain F
34–485（452 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6；1.6-2.2M AS, 0.1M MES, PH6
|
Resolution 4.33 Å R-free 0.334 |
| 2X0B Crystal structure of human angiotensinogen complexed with renin Deposited 2009-12-08 | Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain D
34–485（452 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6；1.6-2.2M AS, 0.1M MES, PH6
|
Resolution 4.33 Å R-free 0.334 |
| 2X0B Crystal structure of human angiotensinogen complexed with renin Deposited 2009-12-08 | Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 3 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain B
34–485（452 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6；1.6-2.2M AS, 0.1M MES, PH6
|
Resolution 4.33 Å R-free 0.334 |
| 2X0B Crystal structure of human angiotensinogen complexed with renin Deposited 2009-12-08 | Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 4 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain H
34–485（452 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6；1.6-2.2M AS, 0.1M MES, PH6
|
Resolution 4.33 Å R-free 0.334 |
| 4AA1 Crystal structure of ANCE in complex with Angiotensin-II Deposited 2011-11-30 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Heteromer；Protein × 2 PDB declaration: dimeric |
Chain P
34–41（8 aa）
|
Not recorded | ZN ZINC ION × 1 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 7.5；0.1 M HEPES 7.5, 1.3 M SODIUM CITRATE
|
Resolution 1.99 Å R-free 0.211 |
| 4APH Human angiotensin-converting enzyme in complex with angiotensin-II Deposited 2012-04-03 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Heteromer；Protein × 2 PDB declaration: dimeric |
Chain P
34–41（8 aa）
|
Not recorded | CL CHLORIDE ION × 2 ZN ZINC ION × 1 PE4 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL × 1 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 ACT ACETATE ION × 5 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 4.7；50MM SODIUM ACETATE PH 4.7, 16% PEG4000, 10UM ZNSO4
|
Resolution 1.99 Å R-free 0.240 |
| 4FYS Human aminopeptidase N (CD13) in complex with angiotensin IV Deposited 2012-07-05 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Heteromer；Protein × 2 PDB declaration: dimeric |
Chain C
36–41（6 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 5 SO4 SULFATE ION × 11 |
X-RAY DIFFRACTION
X-ray crystallization conditions
hanging drop vapor diffusion；pH 5；295 K；2M ammonium sulfate, 0.1M sodium acetate, 10% glycerol, pH 5.0, hanging drop vapor diffusion, temperature 295K
|
Resolution 2.01 Å R-free 0.198 |
| 5E2Q Structure of human DPP3 in complex with angiotensin-II Deposited 2015-10-01 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain B
34–41（8 aa）
Fragment：UNP residues 34-41
|
Not recorded | MG MAGNESIUM ION × 1 K POTASSIUM ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.2；293 K；0.056 M sodium phosphate monobasic monohydrate, 1.344 M potassium phosphate dibasic monohydrate
|
Resolution 2.40 Å R-free 0.247 |
| 5M3X Crystal structure of human angiotensin I-deleted angiotensinogen Deposited 2016-10-17 | Different construct Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
44–485（442 aa）
|
Mutation：N137Q, N271Q, N295Q, C232S, C308S | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293.15 K；1.7M Ammonium Sulfate,
0.1M Citric Acid, pH3.6
|
Resolution 2.63 Å R-free 0.282 |
| 5M3X Crystal structure of human angiotensin I-deleted angiotensinogen Deposited 2016-10-17 | Different construct Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
44–485（442 aa）
|
Mutation：N137Q, N271Q, N295Q, C232S, C308S | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293.15 K；1.7M Ammonium Sulfate,
0.1M Citric Acid, pH3.6
|
Resolution 2.63 Å R-free 0.282 |
| 6I3F Crystal structure of the complex of human angiotensinogen and renin at 2.55 Angstrom Deposited 2018-11-06 | Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
34–485（452 aa）
|
Mutation：N137Q, N271Q, N295Q,C232S,C308S | SO4 SULFATE ION × 10 GOL GLYCEROL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.6；293 K；1.76M Ammonium sulfate
0.1M Tris, pH7.6
|
Resolution 2.55 Å R-free 0.234 |
| 6I3I Crystal structure of reactive center loop (RCL) cleaved angiotensinogen Deposited 2018-11-06 | Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
34–485（452 aa）
|
Mutation：N137Q,N271Q,N295Q,C232S,C308S | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；1.5M ammonium sulfate,
0.1M Tris pH8.5
12% glycerol
|
Resolution 2.97 Å R-free 0.237 |
| 6OS0 Structure of synthetic nanobody-stabilized angiotensin II type 1 receptor bound to angiotensin II Deposited 2019-05-01 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Heteromer；Protein × 3 PDB declaration: trimeric |
Chain B
34–41（8 aa）
Fragment：residues 34-41
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 CL CHLORIDE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
LIPIDIC CUBIC PHASE；pH 7.6；293 K；Protein complex was reconstituted with a 10:1 (w/w) mixture of monoolein and cholesterol. Crystals were grown in 100 mM Tris pH 7.6, 10 mM MgCl2, 25-26% PEG 300
|
Resolution 2.90 Å R-free 0.318 |
13 other PDB entries and 17 assemblies. Open the comparison page and filter oligomeric states
View Construct and Data Evidence
| UniProt name | ANGT_HUMAN |
| Isoform | — |
| PDB entities | 1 |
| Chains and sequence ranges | Author chain A； PDBConstruct 1–452； UniProt 34–485 |
