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6c14

CryoEM structure of mouse PCDH15-1EC-LHFPL5 complex

Method: ELECTRON MICROSCOPY
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Protocadherin-15

Mus musculus

UniProt Q99PJ1

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 4 LHFPL tetraspan subfamily member 5 protein × 2 （Q4KL25） Consistent with protein count

Other States of the Same Protein in the Database

Monomer
5kj4 5kj4 5kj4 5kj4 5tpk 5w1d 6bwn 6bxu 6bxu 6c10 6n22 8ton

14 assemblies; showing the first 12

Homodimer
11iy 6cv7

2 assemblies

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
4apx 4aq8 4aq8 4aqa 4aqe 4xxw 4xxw 6c13 6c14 6eet

10 assemblies

View Construct and Data Evidence
UniProt name PCD15_MOUSE
Isoform Q99PJ1-18
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 5–326； UniProt 1144–1465 Author chain C； PDBConstruct 5–326； UniProt 1144–1465

LHFPL tetraspan subfamily member 5 protein

Mus musculus

UniProt Q4KL25

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 4 Protocadherin-15 × 2 （Q99PJ1） Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
6c14

1 assemblies

View Construct and Data Evidence
UniProt name LHPL5_MOUSE
Isoform —
PDB entities 2
Chains and sequence ranges Author chain B； PDBConstruct 8–226； UniProt 1–219 Author chain D； PDBConstruct 8–226； UniProt 1–219

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id6c14
Deposition date deposition_date2018-01-03
Structure title titleCryoEM structure of mouse PCDH15-1EC-LHFPL5 complex
Keywords keywordsPCDH15, LHFPL5, protocadherin, tip link, hair cell, TMHS, hearing, membrane protein, metal transport; membrane protein, metal transport
Experimental Method methodELECTRON MICROSCOPY
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

6c14__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

6c14__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

6c14__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）36.46 Å
Rg (electron density)36.78 Å
Total Rg36.99 Å
Atom count6740
Residues860
Excluded volume122460 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 6c14__assembly_1__model_1 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (2)

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7. Citations (1)