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6dc5

RSV prefusion F in complex with AM22 Fab

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

RSV fusion glycoprotein

Human respiratory syncytial virus A (strain A2)

UniProt M1E1E4

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Insufficient information Heteromer Protein 3 Fab AM22 heavy chain × 1 （Q6GMX6） Fab AM22 light chain × 1 （Q8TCD0） 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 CADMIUM ION × 1 DI(HYDROXYETHYL)ETHER × 2 Consistent with protein count
2 Insufficient information Heteromer Protein 3 Fab AM22 heavy chain × 1 （Q6GMX6） Fab AM22 light chain × 1 （Q8TCD0） 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 CADMIUM ION × 1 DI(HYDROXYETHYL)ETHER × 2 Consistent with protein count
3 Insufficient information Heteromer Protein 3 Fab AM22 heavy chain × 1 （Q6GMX6） Fab AM22 light chain × 1 （Q8TCD0） 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 CADMIUM ION × 1 DI(HYDROXYETHYL)ETHER × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers
2m7w

1 assemblies

Heteromeric or nucleic-acid complex
5kww 5u68 6a0z 6apd 6cnv 6cxc 6dc3 6dc5 6dc5 6dc5 6g9i 6ona

27 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name M1E1E4_9HIV1
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 518–545； UniProt 1–28 Author chain D； PDBConstruct 518–545； UniProt 1–28 Author chain G； PDBConstruct 518–545； UniProt 1–28

RSV fusion glycoprotein

Human respiratory syncytial virus A (strain A2)

UniProt P03420

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Insufficient information Heteromer Protein 3 Fab AM22 heavy chain × 1 （Q6GMX6） Fab AM22 light chain × 1 （Q8TCD0） 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 CADMIUM ION × 1 DI(HYDROXYETHYL)ETHER × 2 Consistent with protein count
2 Insufficient information Heteromer Protein 3 Fab AM22 heavy chain × 1 （Q6GMX6） Fab AM22 light chain × 1 （Q8TCD0） 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 CADMIUM ION × 1 DI(HYDROXYETHYL)ETHER × 2 Consistent with protein count
3 Insufficient information Heteromer Protein 3 Fab AM22 heavy chain × 1 （Q6GMX6） Fab AM22 light chain × 1 （Q8TCD0） 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 CADMIUM ION × 1 DI(HYDROXYETHYL)ETHER × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers
3kpe 5ea3 5ea4 5ea5 5ea6 5ea7 5ea8 5k6b 5k6c 5k6f 5k6g 5k6h

13 assemblies; showing the first 12

Heteromeric or nucleic-acid complex
29qj 3ixt 3ixt 3o41 3o41 3o45 3o45 3rki 4jhw 4mmq 4mmr 4mms

47 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name FUS_HRSVA
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–513； UniProt 1–513 Author chain D； PDBConstruct 1–513； UniProt 1–513 Author chain G； PDBConstruct 1–513； UniProt 1–513

Fab AM22 heavy chain

Homo sapiens

UniProt Q6GMX6

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Insufficient information Heteromer Protein 3 RSV fusion glycoprotein × 1 （M1E1E4,P03420） Fab AM22 light chain × 1 （Q8TCD0） 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 CADMIUM ION × 1 DI(HYDROXYETHYL)ETHER × 2 Consistent with protein count
2 Insufficient information Heteromer Protein 3 RSV fusion glycoprotein × 1 （M1E1E4,P03420） Fab AM22 light chain × 1 （Q8TCD0） 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 CADMIUM ION × 1 DI(HYDROXYETHYL)ETHER × 2 Consistent with protein count
3 Insufficient information Heteromer Protein 3 RSV fusion glycoprotein × 1 （M1E1E4,P03420） Fab AM22 light chain × 1 （Q8TCD0） 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 CADMIUM ION × 1 DI(HYDROXYETHYL)ETHER × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1za6 1za6 1za6 1za6 4d9l 4d9l 4d9l 4d9l 5o1r 5o1r 5utz 5utz

35 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name Q6GMX6_HUMAN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain B； PDBConstruct 112–228； UniProt 123–239 Author chain E； PDBConstruct 112–228； UniProt 123–239 Author chain H； PDBConstruct 112–228； UniProt 123–239

Fab AM22 light chain

Homo sapiens

UniProt Q8TCD0

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Insufficient information Heteromer Protein 3 RSV fusion glycoprotein × 1 （M1E1E4,P03420） Fab AM22 heavy chain × 1 （Q6GMX6） 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 CADMIUM ION × 1 DI(HYDROXYETHYL)ETHER × 2 Consistent with protein count
2 Insufficient information Heteromer Protein 3 RSV fusion glycoprotein × 1 （M1E1E4,P03420） Fab AM22 heavy chain × 1 （Q6GMX6） 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 CADMIUM ION × 1 DI(HYDROXYETHYL)ETHER × 2 Consistent with protein count
3 Insufficient information Heteromer Protein 3 RSV fusion glycoprotein × 1 （M1E1E4,P03420） Fab AM22 heavy chain × 1 （Q6GMX6） 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 CADMIUM ION × 1 DI(HYDROXYETHYL)ETHER × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1hzh 1n0x 3cfj 3cfj 3cfj 3cfj 3cfk 3cfk 3cfk 3cfk 3cfk 3cfk

67 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name Q8TCD0_HUMAN
Isoform —
PDB entities 3
Chains and sequence ranges Author chain C； PDBConstruct 108–215； UniProt 132–239 Author chain F； PDBConstruct 108–215； UniProt 132–239 Author chain I； PDBConstruct 108–215； UniProt 132–239

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id6dc5
Deposition date deposition_date2018-05-04
Structure title titleRSV prefusion F in complex with AM22 Fab
Keywords keywordsViral fusion glycoprotein, human antibody, IMMUNE SYSTEM; IMMUNE SYSTEM
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

6dc5__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

6dc5__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

6dc5__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）48.56 Å
Rg (electron density)49.98 Å
Total Rg49.56 Å
Atom count6746
Residues879
Excluded volume120720 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 6dc5__assembly_1__model_1 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 6dc5__assembly_2__model_1 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
3 1 6dc5__assembly_3__model_1 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (6)

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6. Fold Classification (SCOP + CATH) 9 domains

CATH v4.4 (9 domains)

Domain ID domain_id6dc5B02
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology40 — Immunoglobulin-like
Homologous superfamily homologous superfamily10 — Immunoglobulins
Domain ID domain_id6dc5C01
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology40 — Immunoglobulin-like
Homologous superfamily homologous superfamily10 — Immunoglobulins
Domain ID domain_id6dc5C02
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology40 — Immunoglobulin-like
Homologous superfamily homologous superfamily10 — Immunoglobulins
Domain ID domain_id6dc5E02
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology40 — Immunoglobulin-like
Homologous superfamily homologous superfamily10 — Immunoglobulins
Domain ID domain_id6dc5F01
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology40 — Immunoglobulin-like
Homologous superfamily homologous superfamily10 — Immunoglobulins
Domain ID domain_id6dc5F02
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology40 — Immunoglobulin-like
Homologous superfamily homologous superfamily10 — Immunoglobulins
Domain ID domain_id6dc5H02
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology40 — Immunoglobulin-like
Homologous superfamily homologous superfamily10 — Immunoglobulins
Domain ID domain_id6dc5I01
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology40 — Immunoglobulin-like
Homologous superfamily homologous superfamily10 — Immunoglobulins
Domain ID domain_id6dc5I02
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology40 — Immunoglobulin-like
Homologous superfamily homologous superfamily10 — Immunoglobulins
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7. Citations (1)