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6euy

Structure of the midlink and cap-binding domains of influenza A polymerase PB2 subunit with a bound azaindazole cap-binding inhibitor

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Polymerase basic protein 2

Influenza A virus (A/Victoria/3/1975(H3N2))

UniProt P31345

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein monomer Monomer Protein 1 ;(2~{S},3~{S})-3-[[5-fluoranyl-2-(5-fluoranyl-1~{H}-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid ; × 1 SULFATE ION × 4 Consistent with protein count
2 Protein monomer Monomer Protein 1 ;(2~{S},3~{S})-3-[[5-fluoranyl-2-(5-fluoranyl-1~{H}-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid ; × 1 Consistent with protein count
3 Protein monomer Monomer Protein 1 ;(2~{S},3~{S})-3-[[5-fluoranyl-2-(5-fluoranyl-1~{H}-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid ; × 1 SULFATE ION × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
2gmo 2vy6 2vy7 2vy8 4nce 4ncm 4p1u 6euv 6euv 6euv 6euv 6euy

18 assemblies; showing the first 12

Homodimer

None

Homotetramer

None

Other homooligomers
2vqz

1 assemblies

Heteromeric or nucleic-acid complex
2jdq 2jdq 4uad 4uae 4uaf 9v44 9v46

7 assemblies

View Construct and Data Evidence
UniProt name PB2_I75A3
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–290； UniProt 247–536 Author chain B； PDBConstruct 1–290； UniProt 247–536 Author chain C； PDBConstruct 1–290； UniProt 247–536

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id6euy
Deposition date deposition_date2017-10-31
Structure title titleStructure of the midlink and cap-binding domains of influenza A polymerase PB2 subunit with a bound azaindazole cap-binding inhibitor
Keywords keywordsInfluenza A polymerase PB2 subunit cap-binding domain cap-binding inhibitor, RNA BINDING PROTEIN; RNA BINDING PROTEIN
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

6euy__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

6euy__assembly_1__model_1 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

6euy__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）20.81 Å
Rg (electron density)19.79 Å
Total Rg20.72 Å
Atom count2216
Residues277
Excluded volume39148 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 6euy__assembly_1__model_1 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 6euy__assembly_2__model_1 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
3 1 6euy__assembly_3__model_1 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (3)

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7. Citations (1)