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6lae

Crystal structure of the DNA-binding domain of human XPA in complex with DNA

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

DNA repair protein complementing XP-A cells

Homo sapiens

UniProt P23025

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–DNA Homooligomer Protein 2 DNA 2 ;DNA (5'-D(P*GP*CP*AP*TP*CP*TP*CP*GP*CP*CP*T)-3') ; × 1 ;DNA (5'-D(P*TP*GP*GP*CP*GP*AP*GP*AP*TP*GP*C)-3') ; × 1 ZINC ION × 2 water × 2 Consistent with all polymers

Other States of the Same Protein in the Database

Monomer
1d4u 1xpa 6j44

3 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
28ke 2jnw 6lae 6ro4 7ad8 8ebt 8ebu 8ebx 8eby 9pcp 9pd3 9pd4

15 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name XPA_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 4–145； UniProt 98–239 Author chain B； PDBConstruct 4–145； UniProt 98–239

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id6lae
Deposition date deposition_date2019-11-12
Structure title titleCrystal structure of the DNA-binding domain of human XPA in complex with DNA
Keywords keywordsProtein-DNA complex, nucleotide excision repair, DNA repair, DNA BINDING PROTEIN, DNA BINDING PROTEIN-DNA complex; DNA BINDING PROTEIN/DNA
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

6lae__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

6lae__assembly_1__model_1 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

6lae__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）23.39 Å
Rg (electron density)22.72 Å
Total Rg23.60 Å
Atom count2392
Residues254
Excluded volume41116 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 6lae__assembly_1__model_1 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (5)

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6. Fold Classification (SCOP + CATH) 2 domains

CATH v4.4 (2 domains)

Domain ID domain_id6laeA01
Class class3 — Alpha Beta
Architecture architecture90 — Alpha-Beta Complex
Topology topology530 — Nucleotide Excision Repair Protein XPA (XPA-MBD); B Chain A
Homologous superfamily homologous superfamily10 — XPA C-terminal domain
Domain ID domain_id6laeB01
Class class3 — Alpha Beta
Architecture architecture90 — Alpha-Beta Complex
Topology topology530 — Nucleotide Excision Repair Protein XPA (XPA-MBD); B Chain A
Homologous superfamily homologous superfamily10 — XPA C-terminal domain
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7. Citations (1)