6mse

Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome

Method: ELECTRON MICROSCOPY

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1. Protein Identity and Related Structures Protein Identity & Related Structures

26S proteasome non-ATPase regulatory subunit 1

Homo sapiens

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 48	26S proteasome non-ATPase regulatory subunit 3 × 1 （O43242） 26S proteasome non-ATPase regulatory subunit 12 × 1 （O00232） 26S proteasome non-ATPase regulatory subunit 11 × 1 （O00231） 26S proteasome non-ATPase regulatory subunit 6 × 1 （Q15008） 26S proteasome non-ATPase regulatory subunit 7 × 1 （P51665） 26S proteasome non-ATPase regulatory subunit 13 × 1 （Q9UNM6） 26S proteasome non-ATPase regulatory subunit 4 × 1 （P55036） 26S proteasome non-ATPase regulatory subunit 14 × 1 （O00487） 26S proteasome non-ATPase regulatory subunit 8 × 1 （P48556） 26S proteasome complex subunit SEM1 × 1 （P60896） 26S proteasome non-ATPase regulatory subunit 2 × 1 （Q13200） 26S proteasome regulatory subunit 7 × 1 （P35998） 26S proteasome regulatory subunit 4 × 1 （P62191） 26S proteasome regulatory subunit 8 × 1 （P62195） 26S proteasome regulatory subunit 6B × 1 （P43686） 26S proteasome regulatory subunit 10B × 1 （A0A087X2I1） 26S proteasome regulatory subunit 6A × 1 （P17980） Ubiquitin × 1 （P0CG47） substrate × 1 Proteasome subunit alpha type-6 × 2 （P60900） Proteasome subunit alpha type-2 × 2 （P25787） Proteasome subunit alpha type-4 × 2 （P25789） Proteasome subunit alpha type-7 × 2 （O14818） Proteasome subunit alpha type-5 × 2 （P28066） Proteasome subunit alpha type-1 × 2 （P25786） Proteasome subunit alpha type-3 × 2 （P25788） Proteasome subunit beta type-6 × 2 （P28072） Proteasome subunit beta type-7 × 2 （Q99436） Proteasome subunit beta type-3 × 2 （P49720） Proteasome subunit beta type-2 × 2 （P49721） Proteasome subunit beta type-5 × 2 （P28074） Proteasome subunit beta type-1 × 2 （P20618） Proteasome subunit beta type-4 × 2 （P28070） ZINC ION × 1 ADENOSINE-5'-TRIPHOSPHATE × 3 MAGNESIUM ION × 3 ADENOSINE-5'-DIPHOSPHATE × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PSMD1_HUMAN
Isoform	—
PDB entities	1
Chains and sequence ranges	Author chain U； PDBConstruct 1–953； UniProt 1–953

26S proteasome non-ATPase regulatory subunit 3

Homo sapiens

UniProt O43242

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 48	26S proteasome non-ATPase regulatory subunit 1 × 1 （Q99460） 26S proteasome non-ATPase regulatory subunit 12 × 1 （O00232） 26S proteasome non-ATPase regulatory subunit 11 × 1 （O00231） 26S proteasome non-ATPase regulatory subunit 6 × 1 （Q15008） 26S proteasome non-ATPase regulatory subunit 7 × 1 （P51665） 26S proteasome non-ATPase regulatory subunit 13 × 1 （Q9UNM6） 26S proteasome non-ATPase regulatory subunit 4 × 1 （P55036） 26S proteasome non-ATPase regulatory subunit 14 × 1 （O00487） 26S proteasome non-ATPase regulatory subunit 8 × 1 （P48556） 26S proteasome complex subunit SEM1 × 1 （P60896） 26S proteasome non-ATPase regulatory subunit 2 × 1 （Q13200） 26S proteasome regulatory subunit 7 × 1 （P35998） 26S proteasome regulatory subunit 4 × 1 （P62191） 26S proteasome regulatory subunit 8 × 1 （P62195） 26S proteasome regulatory subunit 6B × 1 （P43686） 26S proteasome regulatory subunit 10B × 1 （A0A087X2I1） 26S proteasome regulatory subunit 6A × 1 （P17980） Ubiquitin × 1 （P0CG47） substrate × 1 Proteasome subunit alpha type-6 × 2 （P60900） Proteasome subunit alpha type-2 × 2 （P25787） Proteasome subunit alpha type-4 × 2 （P25789） Proteasome subunit alpha type-7 × 2 （O14818） Proteasome subunit alpha type-5 × 2 （P28066） Proteasome subunit alpha type-1 × 2 （P25786） Proteasome subunit alpha type-3 × 2 （P25788） Proteasome subunit beta type-6 × 2 （P28072） Proteasome subunit beta type-7 × 2 （Q99436） Proteasome subunit beta type-3 × 2 （P49720） Proteasome subunit beta type-2 × 2 （P49721） Proteasome subunit beta type-5 × 2 （P28074） Proteasome subunit beta type-1 × 2 （P20618） Proteasome subunit beta type-4 × 2 （P28070） ZINC ION × 1 ADENOSINE-5'-TRIPHOSPHATE × 3 MAGNESIUM ION × 3 ADENOSINE-5'-DIPHOSPHATE × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PSMD3_HUMAN
Isoform	—
PDB entities	2
Chains and sequence ranges	Author chain V； PDBConstruct 1–533； UniProt 2–534

26S proteasome non-ATPase regulatory subunit 12

Homo sapiens

UniProt O00232

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 48	26S proteasome non-ATPase regulatory subunit 1 × 1 （Q99460） 26S proteasome non-ATPase regulatory subunit 3 × 1 （O43242） 26S proteasome non-ATPase regulatory subunit 11 × 1 （O00231） 26S proteasome non-ATPase regulatory subunit 6 × 1 （Q15008） 26S proteasome non-ATPase regulatory subunit 7 × 1 （P51665） 26S proteasome non-ATPase regulatory subunit 13 × 1 （Q9UNM6） 26S proteasome non-ATPase regulatory subunit 4 × 1 （P55036） 26S proteasome non-ATPase regulatory subunit 14 × 1 （O00487） 26S proteasome non-ATPase regulatory subunit 8 × 1 （P48556） 26S proteasome complex subunit SEM1 × 1 （P60896） 26S proteasome non-ATPase regulatory subunit 2 × 1 （Q13200） 26S proteasome regulatory subunit 7 × 1 （P35998） 26S proteasome regulatory subunit 4 × 1 （P62191） 26S proteasome regulatory subunit 8 × 1 （P62195） 26S proteasome regulatory subunit 6B × 1 （P43686） 26S proteasome regulatory subunit 10B × 1 （A0A087X2I1） 26S proteasome regulatory subunit 6A × 1 （P17980） Ubiquitin × 1 （P0CG47） substrate × 1 Proteasome subunit alpha type-6 × 2 （P60900） Proteasome subunit alpha type-2 × 2 （P25787） Proteasome subunit alpha type-4 × 2 （P25789） Proteasome subunit alpha type-7 × 2 （O14818） Proteasome subunit alpha type-5 × 2 （P28066） Proteasome subunit alpha type-1 × 2 （P25786） Proteasome subunit alpha type-3 × 2 （P25788） Proteasome subunit beta type-6 × 2 （P28072） Proteasome subunit beta type-7 × 2 （Q99436） Proteasome subunit beta type-3 × 2 （P49720） Proteasome subunit beta type-2 × 2 （P49721） Proteasome subunit beta type-5 × 2 （P28074） Proteasome subunit beta type-1 × 2 （P20618） Proteasome subunit beta type-4 × 2 （P28070） ZINC ION × 1 ADENOSINE-5'-TRIPHOSPHATE × 3 MAGNESIUM ION × 3 ADENOSINE-5'-DIPHOSPHATE × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PSD12_HUMAN
Isoform	—
PDB entities	3
Chains and sequence ranges	Author chain W； PDBConstruct 1–456； UniProt 1–456

26S proteasome non-ATPase regulatory subunit 11

Homo sapiens

UniProt O00231

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 48	26S proteasome non-ATPase regulatory subunit 1 × 1 （Q99460） 26S proteasome non-ATPase regulatory subunit 3 × 1 （O43242） 26S proteasome non-ATPase regulatory subunit 12 × 1 （O00232） 26S proteasome non-ATPase regulatory subunit 6 × 1 （Q15008） 26S proteasome non-ATPase regulatory subunit 7 × 1 （P51665） 26S proteasome non-ATPase regulatory subunit 13 × 1 （Q9UNM6） 26S proteasome non-ATPase regulatory subunit 4 × 1 （P55036） 26S proteasome non-ATPase regulatory subunit 14 × 1 （O00487） 26S proteasome non-ATPase regulatory subunit 8 × 1 （P48556） 26S proteasome complex subunit SEM1 × 1 （P60896） 26S proteasome non-ATPase regulatory subunit 2 × 1 （Q13200） 26S proteasome regulatory subunit 7 × 1 （P35998） 26S proteasome regulatory subunit 4 × 1 （P62191） 26S proteasome regulatory subunit 8 × 1 （P62195） 26S proteasome regulatory subunit 6B × 1 （P43686） 26S proteasome regulatory subunit 10B × 1 （A0A087X2I1） 26S proteasome regulatory subunit 6A × 1 （P17980） Ubiquitin × 1 （P0CG47） substrate × 1 Proteasome subunit alpha type-6 × 2 （P60900） Proteasome subunit alpha type-2 × 2 （P25787） Proteasome subunit alpha type-4 × 2 （P25789） Proteasome subunit alpha type-7 × 2 （O14818） Proteasome subunit alpha type-5 × 2 （P28066） Proteasome subunit alpha type-1 × 2 （P25786） Proteasome subunit alpha type-3 × 2 （P25788） Proteasome subunit beta type-6 × 2 （P28072） Proteasome subunit beta type-7 × 2 （Q99436） Proteasome subunit beta type-3 × 2 （P49720） Proteasome subunit beta type-2 × 2 （P49721） Proteasome subunit beta type-5 × 2 （P28074） Proteasome subunit beta type-1 × 2 （P20618） Proteasome subunit beta type-4 × 2 （P28070） ZINC ION × 1 ADENOSINE-5'-TRIPHOSPHATE × 3 MAGNESIUM ION × 3 ADENOSINE-5'-DIPHOSPHATE × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PSD11_HUMAN
Isoform	—
PDB entities	4
Chains and sequence ranges	Author chain X； PDBConstruct 1–422； UniProt 1–422

26S proteasome non-ATPase regulatory subunit 6

Homo sapiens

UniProt Q15008

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 48	26S proteasome non-ATPase regulatory subunit 1 × 1 （Q99460） 26S proteasome non-ATPase regulatory subunit 3 × 1 （O43242） 26S proteasome non-ATPase regulatory subunit 12 × 1 （O00232） 26S proteasome non-ATPase regulatory subunit 11 × 1 （O00231） 26S proteasome non-ATPase regulatory subunit 7 × 1 （P51665） 26S proteasome non-ATPase regulatory subunit 13 × 1 （Q9UNM6） 26S proteasome non-ATPase regulatory subunit 4 × 1 （P55036） 26S proteasome non-ATPase regulatory subunit 14 × 1 （O00487） 26S proteasome non-ATPase regulatory subunit 8 × 1 （P48556） 26S proteasome complex subunit SEM1 × 1 （P60896） 26S proteasome non-ATPase regulatory subunit 2 × 1 （Q13200） 26S proteasome regulatory subunit 7 × 1 （P35998） 26S proteasome regulatory subunit 4 × 1 （P62191） 26S proteasome regulatory subunit 8 × 1 （P62195） 26S proteasome regulatory subunit 6B × 1 （P43686） 26S proteasome regulatory subunit 10B × 1 （A0A087X2I1） 26S proteasome regulatory subunit 6A × 1 （P17980） Ubiquitin × 1 （P0CG47） substrate × 1 Proteasome subunit alpha type-6 × 2 （P60900） Proteasome subunit alpha type-2 × 2 （P25787） Proteasome subunit alpha type-4 × 2 （P25789） Proteasome subunit alpha type-7 × 2 （O14818） Proteasome subunit alpha type-5 × 2 （P28066） Proteasome subunit alpha type-1 × 2 （P25786） Proteasome subunit alpha type-3 × 2 （P25788） Proteasome subunit beta type-6 × 2 （P28072） Proteasome subunit beta type-7 × 2 （Q99436） Proteasome subunit beta type-3 × 2 （P49720） Proteasome subunit beta type-2 × 2 （P49721） Proteasome subunit beta type-5 × 2 （P28074） Proteasome subunit beta type-1 × 2 （P20618） Proteasome subunit beta type-4 × 2 （P28070） ZINC ION × 1 ADENOSINE-5'-TRIPHOSPHATE × 3 MAGNESIUM ION × 3 ADENOSINE-5'-DIPHOSPHATE × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PSMD6_HUMAN
Isoform	—
PDB entities	5
Chains and sequence ranges	Author chain Y； PDBConstruct 1–389； UniProt 1–389

26S proteasome non-ATPase regulatory subunit 7

Homo sapiens

UniProt P51665

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 48	26S proteasome non-ATPase regulatory subunit 1 × 1 （Q99460） 26S proteasome non-ATPase regulatory subunit 3 × 1 （O43242） 26S proteasome non-ATPase regulatory subunit 12 × 1 （O00232） 26S proteasome non-ATPase regulatory subunit 11 × 1 （O00231） 26S proteasome non-ATPase regulatory subunit 6 × 1 （Q15008） 26S proteasome non-ATPase regulatory subunit 13 × 1 （Q9UNM6） 26S proteasome non-ATPase regulatory subunit 4 × 1 （P55036） 26S proteasome non-ATPase regulatory subunit 14 × 1 （O00487） 26S proteasome non-ATPase regulatory subunit 8 × 1 （P48556） 26S proteasome complex subunit SEM1 × 1 （P60896） 26S proteasome non-ATPase regulatory subunit 2 × 1 （Q13200） 26S proteasome regulatory subunit 7 × 1 （P35998） 26S proteasome regulatory subunit 4 × 1 （P62191） 26S proteasome regulatory subunit 8 × 1 （P62195） 26S proteasome regulatory subunit 6B × 1 （P43686） 26S proteasome regulatory subunit 10B × 1 （A0A087X2I1） 26S proteasome regulatory subunit 6A × 1 （P17980） Ubiquitin × 1 （P0CG47） substrate × 1 Proteasome subunit alpha type-6 × 2 （P60900） Proteasome subunit alpha type-2 × 2 （P25787） Proteasome subunit alpha type-4 × 2 （P25789） Proteasome subunit alpha type-7 × 2 （O14818） Proteasome subunit alpha type-5 × 2 （P28066） Proteasome subunit alpha type-1 × 2 （P25786） Proteasome subunit alpha type-3 × 2 （P25788） Proteasome subunit beta type-6 × 2 （P28072） Proteasome subunit beta type-7 × 2 （Q99436） Proteasome subunit beta type-3 × 2 （P49720） Proteasome subunit beta type-2 × 2 （P49721） Proteasome subunit beta type-5 × 2 （P28074） Proteasome subunit beta type-1 × 2 （P20618） Proteasome subunit beta type-4 × 2 （P28070） ZINC ION × 1 ADENOSINE-5'-TRIPHOSPHATE × 3 MAGNESIUM ION × 3 ADENOSINE-5'-DIPHOSPHATE × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PSMD7_HUMAN
Isoform	—
PDB entities	6
Chains and sequence ranges	Author chain Z； PDBConstruct 1–324； UniProt 1–324

26S proteasome non-ATPase regulatory subunit 13

Homo sapiens

UniProt Q9UNM6

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 48	26S proteasome non-ATPase regulatory subunit 1 × 1 （Q99460） 26S proteasome non-ATPase regulatory subunit 3 × 1 （O43242） 26S proteasome non-ATPase regulatory subunit 12 × 1 （O00232） 26S proteasome non-ATPase regulatory subunit 11 × 1 （O00231） 26S proteasome non-ATPase regulatory subunit 6 × 1 （Q15008） 26S proteasome non-ATPase regulatory subunit 7 × 1 （P51665） 26S proteasome non-ATPase regulatory subunit 4 × 1 （P55036） 26S proteasome non-ATPase regulatory subunit 14 × 1 （O00487） 26S proteasome non-ATPase regulatory subunit 8 × 1 （P48556） 26S proteasome complex subunit SEM1 × 1 （P60896） 26S proteasome non-ATPase regulatory subunit 2 × 1 （Q13200） 26S proteasome regulatory subunit 7 × 1 （P35998） 26S proteasome regulatory subunit 4 × 1 （P62191） 26S proteasome regulatory subunit 8 × 1 （P62195） 26S proteasome regulatory subunit 6B × 1 （P43686） 26S proteasome regulatory subunit 10B × 1 （A0A087X2I1） 26S proteasome regulatory subunit 6A × 1 （P17980） Ubiquitin × 1 （P0CG47） substrate × 1 Proteasome subunit alpha type-6 × 2 （P60900） Proteasome subunit alpha type-2 × 2 （P25787） Proteasome subunit alpha type-4 × 2 （P25789） Proteasome subunit alpha type-7 × 2 （O14818） Proteasome subunit alpha type-5 × 2 （P28066） Proteasome subunit alpha type-1 × 2 （P25786） Proteasome subunit alpha type-3 × 2 （P25788） Proteasome subunit beta type-6 × 2 （P28072） Proteasome subunit beta type-7 × 2 （Q99436） Proteasome subunit beta type-3 × 2 （P49720） Proteasome subunit beta type-2 × 2 （P49721） Proteasome subunit beta type-5 × 2 （P28074） Proteasome subunit beta type-1 × 2 （P20618） Proteasome subunit beta type-4 × 2 （P28070） ZINC ION × 1 ADENOSINE-5'-TRIPHOSPHATE × 3 MAGNESIUM ION × 3 ADENOSINE-5'-DIPHOSPHATE × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PSD13_HUMAN
Isoform	—
PDB entities	7
Chains and sequence ranges	Author chain a； PDBConstruct 1–376； UniProt 1–376

26S proteasome non-ATPase regulatory subunit 4

Homo sapiens

UniProt P55036

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 48	26S proteasome non-ATPase regulatory subunit 1 × 1 （Q99460） 26S proteasome non-ATPase regulatory subunit 3 × 1 （O43242） 26S proteasome non-ATPase regulatory subunit 12 × 1 （O00232） 26S proteasome non-ATPase regulatory subunit 11 × 1 （O00231） 26S proteasome non-ATPase regulatory subunit 6 × 1 （Q15008） 26S proteasome non-ATPase regulatory subunit 7 × 1 （P51665） 26S proteasome non-ATPase regulatory subunit 13 × 1 （Q9UNM6） 26S proteasome non-ATPase regulatory subunit 14 × 1 （O00487） 26S proteasome non-ATPase regulatory subunit 8 × 1 （P48556） 26S proteasome complex subunit SEM1 × 1 （P60896） 26S proteasome non-ATPase regulatory subunit 2 × 1 （Q13200） 26S proteasome regulatory subunit 7 × 1 （P35998） 26S proteasome regulatory subunit 4 × 1 （P62191） 26S proteasome regulatory subunit 8 × 1 （P62195） 26S proteasome regulatory subunit 6B × 1 （P43686） 26S proteasome regulatory subunit 10B × 1 （A0A087X2I1） 26S proteasome regulatory subunit 6A × 1 （P17980） Ubiquitin × 1 （P0CG47） substrate × 1 Proteasome subunit alpha type-6 × 2 （P60900） Proteasome subunit alpha type-2 × 2 （P25787） Proteasome subunit alpha type-4 × 2 （P25789） Proteasome subunit alpha type-7 × 2 （O14818） Proteasome subunit alpha type-5 × 2 （P28066） Proteasome subunit alpha type-1 × 2 （P25786） Proteasome subunit alpha type-3 × 2 （P25788） Proteasome subunit beta type-6 × 2 （P28072） Proteasome subunit beta type-7 × 2 （Q99436） Proteasome subunit beta type-3 × 2 （P49720） Proteasome subunit beta type-2 × 2 （P49721） Proteasome subunit beta type-5 × 2 （P28074） Proteasome subunit beta type-1 × 2 （P20618） Proteasome subunit beta type-4 × 2 （P28070） ZINC ION × 1 ADENOSINE-5'-TRIPHOSPHATE × 3 MAGNESIUM ION × 3 ADENOSINE-5'-DIPHOSPHATE × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PSMD4_HUMAN
Isoform	—
PDB entities	8
Chains and sequence ranges	Author chain b； PDBConstruct 1–377； UniProt 1–377

26S proteasome non-ATPase regulatory subunit 14

Homo sapiens

UniProt O00487

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 48	26S proteasome non-ATPase regulatory subunit 1 × 1 （Q99460） 26S proteasome non-ATPase regulatory subunit 3 × 1 （O43242） 26S proteasome non-ATPase regulatory subunit 12 × 1 （O00232） 26S proteasome non-ATPase regulatory subunit 11 × 1 （O00231） 26S proteasome non-ATPase regulatory subunit 6 × 1 （Q15008） 26S proteasome non-ATPase regulatory subunit 7 × 1 （P51665） 26S proteasome non-ATPase regulatory subunit 13 × 1 （Q9UNM6） 26S proteasome non-ATPase regulatory subunit 4 × 1 （P55036） 26S proteasome non-ATPase regulatory subunit 8 × 1 （P48556） 26S proteasome complex subunit SEM1 × 1 （P60896） 26S proteasome non-ATPase regulatory subunit 2 × 1 （Q13200） 26S proteasome regulatory subunit 7 × 1 （P35998） 26S proteasome regulatory subunit 4 × 1 （P62191） 26S proteasome regulatory subunit 8 × 1 （P62195） 26S proteasome regulatory subunit 6B × 1 （P43686） 26S proteasome regulatory subunit 10B × 1 （A0A087X2I1） 26S proteasome regulatory subunit 6A × 1 （P17980） Ubiquitin × 1 （P0CG47） substrate × 1 Proteasome subunit alpha type-6 × 2 （P60900） Proteasome subunit alpha type-2 × 2 （P25787） Proteasome subunit alpha type-4 × 2 （P25789） Proteasome subunit alpha type-7 × 2 （O14818） Proteasome subunit alpha type-5 × 2 （P28066） Proteasome subunit alpha type-1 × 2 （P25786） Proteasome subunit alpha type-3 × 2 （P25788） Proteasome subunit beta type-6 × 2 （P28072） Proteasome subunit beta type-7 × 2 （Q99436） Proteasome subunit beta type-3 × 2 （P49720） Proteasome subunit beta type-2 × 2 （P49721） Proteasome subunit beta type-5 × 2 （P28074） Proteasome subunit beta type-1 × 2 （P20618） Proteasome subunit beta type-4 × 2 （P28070） ZINC ION × 1 ADENOSINE-5'-TRIPHOSPHATE × 3 MAGNESIUM ION × 3 ADENOSINE-5'-DIPHOSPHATE × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PSDE_HUMAN
Isoform	—
PDB entities	9
Chains and sequence ranges	Author chain c； PDBConstruct 1–309； UniProt 2–310

26S proteasome non-ATPase regulatory subunit 8

Homo sapiens

UniProt P48556

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 48	26S proteasome non-ATPase regulatory subunit 1 × 1 （Q99460） 26S proteasome non-ATPase regulatory subunit 3 × 1 （O43242） 26S proteasome non-ATPase regulatory subunit 12 × 1 （O00232） 26S proteasome non-ATPase regulatory subunit 11 × 1 （O00231） 26S proteasome non-ATPase regulatory subunit 6 × 1 （Q15008） 26S proteasome non-ATPase regulatory subunit 7 × 1 （P51665） 26S proteasome non-ATPase regulatory subunit 13 × 1 （Q9UNM6） 26S proteasome non-ATPase regulatory subunit 4 × 1 （P55036） 26S proteasome non-ATPase regulatory subunit 14 × 1 （O00487） 26S proteasome complex subunit SEM1 × 1 （P60896） 26S proteasome non-ATPase regulatory subunit 2 × 1 （Q13200） 26S proteasome regulatory subunit 7 × 1 （P35998） 26S proteasome regulatory subunit 4 × 1 （P62191） 26S proteasome regulatory subunit 8 × 1 （P62195） 26S proteasome regulatory subunit 6B × 1 （P43686） 26S proteasome regulatory subunit 10B × 1 （A0A087X2I1） 26S proteasome regulatory subunit 6A × 1 （P17980） Ubiquitin × 1 （P0CG47） substrate × 1 Proteasome subunit alpha type-6 × 2 （P60900） Proteasome subunit alpha type-2 × 2 （P25787） Proteasome subunit alpha type-4 × 2 （P25789） Proteasome subunit alpha type-7 × 2 （O14818） Proteasome subunit alpha type-5 × 2 （P28066） Proteasome subunit alpha type-1 × 2 （P25786） Proteasome subunit alpha type-3 × 2 （P25788） Proteasome subunit beta type-6 × 2 （P28072） Proteasome subunit beta type-7 × 2 （Q99436） Proteasome subunit beta type-3 × 2 （P49720） Proteasome subunit beta type-2 × 2 （P49721） Proteasome subunit beta type-5 × 2 （P28074） Proteasome subunit beta type-1 × 2 （P20618） Proteasome subunit beta type-4 × 2 （P28070） ZINC ION × 1 ADENOSINE-5'-TRIPHOSPHATE × 3 MAGNESIUM ION × 3 ADENOSINE-5'-DIPHOSPHATE × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PSMD8_HUMAN
Isoform	—
PDB entities	10
Chains and sequence ranges	Author chain d； PDBConstruct 1–349； UniProt 2–350

26S proteasome complex subunit SEM1

Homo sapiens

UniProt P60896

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 48	26S proteasome non-ATPase regulatory subunit 1 × 1 （Q99460） 26S proteasome non-ATPase regulatory subunit 3 × 1 （O43242） 26S proteasome non-ATPase regulatory subunit 12 × 1 （O00232） 26S proteasome non-ATPase regulatory subunit 11 × 1 （O00231） 26S proteasome non-ATPase regulatory subunit 6 × 1 （Q15008） 26S proteasome non-ATPase regulatory subunit 7 × 1 （P51665） 26S proteasome non-ATPase regulatory subunit 13 × 1 （Q9UNM6） 26S proteasome non-ATPase regulatory subunit 4 × 1 （P55036） 26S proteasome non-ATPase regulatory subunit 14 × 1 （O00487） 26S proteasome non-ATPase regulatory subunit 8 × 1 （P48556） 26S proteasome non-ATPase regulatory subunit 2 × 1 （Q13200） 26S proteasome regulatory subunit 7 × 1 （P35998） 26S proteasome regulatory subunit 4 × 1 （P62191） 26S proteasome regulatory subunit 8 × 1 （P62195） 26S proteasome regulatory subunit 6B × 1 （P43686） 26S proteasome regulatory subunit 10B × 1 （A0A087X2I1） 26S proteasome regulatory subunit 6A × 1 （P17980） Ubiquitin × 1 （P0CG47） substrate × 1 Proteasome subunit alpha type-6 × 2 （P60900） Proteasome subunit alpha type-2 × 2 （P25787） Proteasome subunit alpha type-4 × 2 （P25789） Proteasome subunit alpha type-7 × 2 （O14818） Proteasome subunit alpha type-5 × 2 （P28066） Proteasome subunit alpha type-1 × 2 （P25786） Proteasome subunit alpha type-3 × 2 （P25788） Proteasome subunit beta type-6 × 2 （P28072） Proteasome subunit beta type-7 × 2 （Q99436） Proteasome subunit beta type-3 × 2 （P49720） Proteasome subunit beta type-2 × 2 （P49721） Proteasome subunit beta type-5 × 2 （P28074） Proteasome subunit beta type-1 × 2 （P20618） Proteasome subunit beta type-4 × 2 （P28070） ZINC ION × 1 ADENOSINE-5'-TRIPHOSPHATE × 3 MAGNESIUM ION × 3 ADENOSINE-5'-DIPHOSPHATE × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	SEM1_HUMAN
Isoform	—
PDB entities	11
Chains and sequence ranges	Author chain e； PDBConstruct 1–70； UniProt 1–70

26S proteasome non-ATPase regulatory subunit 2

Homo sapiens

UniProt Q13200

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 48	26S proteasome non-ATPase regulatory subunit 1 × 1 （Q99460） 26S proteasome non-ATPase regulatory subunit 3 × 1 （O43242） 26S proteasome non-ATPase regulatory subunit 12 × 1 （O00232） 26S proteasome non-ATPase regulatory subunit 11 × 1 （O00231） 26S proteasome non-ATPase regulatory subunit 6 × 1 （Q15008） 26S proteasome non-ATPase regulatory subunit 7 × 1 （P51665） 26S proteasome non-ATPase regulatory subunit 13 × 1 （Q9UNM6） 26S proteasome non-ATPase regulatory subunit 4 × 1 （P55036） 26S proteasome non-ATPase regulatory subunit 14 × 1 （O00487） 26S proteasome non-ATPase regulatory subunit 8 × 1 （P48556） 26S proteasome complex subunit SEM1 × 1 （P60896） 26S proteasome regulatory subunit 7 × 1 （P35998） 26S proteasome regulatory subunit 4 × 1 （P62191） 26S proteasome regulatory subunit 8 × 1 （P62195） 26S proteasome regulatory subunit 6B × 1 （P43686） 26S proteasome regulatory subunit 10B × 1 （A0A087X2I1） 26S proteasome regulatory subunit 6A × 1 （P17980） Ubiquitin × 1 （P0CG47） substrate × 1 Proteasome subunit alpha type-6 × 2 （P60900） Proteasome subunit alpha type-2 × 2 （P25787） Proteasome subunit alpha type-4 × 2 （P25789） Proteasome subunit alpha type-7 × 2 （O14818） Proteasome subunit alpha type-5 × 2 （P28066） Proteasome subunit alpha type-1 × 2 （P25786） Proteasome subunit alpha type-3 × 2 （P25788） Proteasome subunit beta type-6 × 2 （P28072） Proteasome subunit beta type-7 × 2 （Q99436） Proteasome subunit beta type-3 × 2 （P49720） Proteasome subunit beta type-2 × 2 （P49721） Proteasome subunit beta type-5 × 2 （P28074） Proteasome subunit beta type-1 × 2 （P20618） Proteasome subunit beta type-4 × 2 （P28070） ZINC ION × 1 ADENOSINE-5'-TRIPHOSPHATE × 3 MAGNESIUM ION × 3 ADENOSINE-5'-DIPHOSPHATE × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PSMD2_HUMAN
Isoform	—
PDB entities	12
Chains and sequence ranges	Author chain f； PDBConstruct 1–892； UniProt 1–892

26S proteasome regulatory subunit 7

Homo sapiens

UniProt P35998

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 48	26S proteasome non-ATPase regulatory subunit 1 × 1 （Q99460） 26S proteasome non-ATPase regulatory subunit 3 × 1 （O43242） 26S proteasome non-ATPase regulatory subunit 12 × 1 （O00232） 26S proteasome non-ATPase regulatory subunit 11 × 1 （O00231） 26S proteasome non-ATPase regulatory subunit 6 × 1 （Q15008） 26S proteasome non-ATPase regulatory subunit 7 × 1 （P51665） 26S proteasome non-ATPase regulatory subunit 13 × 1 （Q9UNM6） 26S proteasome non-ATPase regulatory subunit 4 × 1 （P55036） 26S proteasome non-ATPase regulatory subunit 14 × 1 （O00487） 26S proteasome non-ATPase regulatory subunit 8 × 1 （P48556） 26S proteasome complex subunit SEM1 × 1 （P60896） 26S proteasome non-ATPase regulatory subunit 2 × 1 （Q13200） 26S proteasome regulatory subunit 4 × 1 （P62191） 26S proteasome regulatory subunit 8 × 1 （P62195） 26S proteasome regulatory subunit 6B × 1 （P43686） 26S proteasome regulatory subunit 10B × 1 （A0A087X2I1） 26S proteasome regulatory subunit 6A × 1 （P17980） Ubiquitin × 1 （P0CG47） substrate × 1 Proteasome subunit alpha type-6 × 2 （P60900） Proteasome subunit alpha type-2 × 2 （P25787） Proteasome subunit alpha type-4 × 2 （P25789） Proteasome subunit alpha type-7 × 2 （O14818） Proteasome subunit alpha type-5 × 2 （P28066） Proteasome subunit alpha type-1 × 2 （P25786） Proteasome subunit alpha type-3 × 2 （P25788） Proteasome subunit beta type-6 × 2 （P28072） Proteasome subunit beta type-7 × 2 （Q99436） Proteasome subunit beta type-3 × 2 （P49720） Proteasome subunit beta type-2 × 2 （P49721） Proteasome subunit beta type-5 × 2 （P28074） Proteasome subunit beta type-1 × 2 （P20618） Proteasome subunit beta type-4 × 2 （P28070） ZINC ION × 1 ADENOSINE-5'-TRIPHOSPHATE × 3 MAGNESIUM ION × 3 ADENOSINE-5'-DIPHOSPHATE × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PRS7_HUMAN
Isoform	—
PDB entities	13
Chains and sequence ranges	Author chain A； PDBConstruct 1–433； UniProt 1–433

26S proteasome regulatory subunit 4

Homo sapiens

UniProt P62191

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 48	26S proteasome non-ATPase regulatory subunit 1 × 1 （Q99460） 26S proteasome non-ATPase regulatory subunit 3 × 1 （O43242） 26S proteasome non-ATPase regulatory subunit 12 × 1 （O00232） 26S proteasome non-ATPase regulatory subunit 11 × 1 （O00231） 26S proteasome non-ATPase regulatory subunit 6 × 1 （Q15008） 26S proteasome non-ATPase regulatory subunit 7 × 1 （P51665） 26S proteasome non-ATPase regulatory subunit 13 × 1 （Q9UNM6） 26S proteasome non-ATPase regulatory subunit 4 × 1 （P55036） 26S proteasome non-ATPase regulatory subunit 14 × 1 （O00487） 26S proteasome non-ATPase regulatory subunit 8 × 1 （P48556） 26S proteasome complex subunit SEM1 × 1 （P60896） 26S proteasome non-ATPase regulatory subunit 2 × 1 （Q13200） 26S proteasome regulatory subunit 7 × 1 （P35998） 26S proteasome regulatory subunit 8 × 1 （P62195） 26S proteasome regulatory subunit 6B × 1 （P43686） 26S proteasome regulatory subunit 10B × 1 （A0A087X2I1） 26S proteasome regulatory subunit 6A × 1 （P17980） Ubiquitin × 1 （P0CG47） substrate × 1 Proteasome subunit alpha type-6 × 2 （P60900） Proteasome subunit alpha type-2 × 2 （P25787） Proteasome subunit alpha type-4 × 2 （P25789） Proteasome subunit alpha type-7 × 2 （O14818） Proteasome subunit alpha type-5 × 2 （P28066） Proteasome subunit alpha type-1 × 2 （P25786） Proteasome subunit alpha type-3 × 2 （P25788） Proteasome subunit beta type-6 × 2 （P28072） Proteasome subunit beta type-7 × 2 （Q99436） Proteasome subunit beta type-3 × 2 （P49720） Proteasome subunit beta type-2 × 2 （P49721） Proteasome subunit beta type-5 × 2 （P28074） Proteasome subunit beta type-1 × 2 （P20618） Proteasome subunit beta type-4 × 2 （P28070） ZINC ION × 1 ADENOSINE-5'-TRIPHOSPHATE × 3 MAGNESIUM ION × 3 ADENOSINE-5'-DIPHOSPHATE × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PRS4_HUMAN
Isoform	—
PDB entities	14
Chains and sequence ranges	Author chain B； PDBConstruct 1–440； UniProt 1–440

26S proteasome regulatory subunit 8

Homo sapiens

UniProt P62195

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 48	26S proteasome non-ATPase regulatory subunit 1 × 1 （Q99460） 26S proteasome non-ATPase regulatory subunit 3 × 1 （O43242） 26S proteasome non-ATPase regulatory subunit 12 × 1 （O00232） 26S proteasome non-ATPase regulatory subunit 11 × 1 （O00231） 26S proteasome non-ATPase regulatory subunit 6 × 1 （Q15008） 26S proteasome non-ATPase regulatory subunit 7 × 1 （P51665） 26S proteasome non-ATPase regulatory subunit 13 × 1 （Q9UNM6） 26S proteasome non-ATPase regulatory subunit 4 × 1 （P55036） 26S proteasome non-ATPase regulatory subunit 14 × 1 （O00487） 26S proteasome non-ATPase regulatory subunit 8 × 1 （P48556） 26S proteasome complex subunit SEM1 × 1 （P60896） 26S proteasome non-ATPase regulatory subunit 2 × 1 （Q13200） 26S proteasome regulatory subunit 7 × 1 （P35998） 26S proteasome regulatory subunit 4 × 1 （P62191） 26S proteasome regulatory subunit 6B × 1 （P43686） 26S proteasome regulatory subunit 10B × 1 （A0A087X2I1） 26S proteasome regulatory subunit 6A × 1 （P17980） Ubiquitin × 1 （P0CG47） substrate × 1 Proteasome subunit alpha type-6 × 2 （P60900） Proteasome subunit alpha type-2 × 2 （P25787） Proteasome subunit alpha type-4 × 2 （P25789） Proteasome subunit alpha type-7 × 2 （O14818） Proteasome subunit alpha type-5 × 2 （P28066） Proteasome subunit alpha type-1 × 2 （P25786） Proteasome subunit alpha type-3 × 2 （P25788） Proteasome subunit beta type-6 × 2 （P28072） Proteasome subunit beta type-7 × 2 （Q99436） Proteasome subunit beta type-3 × 2 （P49720） Proteasome subunit beta type-2 × 2 （P49721） Proteasome subunit beta type-5 × 2 （P28074） Proteasome subunit beta type-1 × 2 （P20618） Proteasome subunit beta type-4 × 2 （P28070） ZINC ION × 1 ADENOSINE-5'-TRIPHOSPHATE × 3 MAGNESIUM ION × 3 ADENOSINE-5'-DIPHOSPHATE × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PRS8_HUMAN
Isoform	—
PDB entities	15
Chains and sequence ranges	Author chain C； PDBConstruct 1–398； UniProt 9–406

26S proteasome regulatory subunit 6B

Homo sapiens

UniProt P43686

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 48	26S proteasome non-ATPase regulatory subunit 1 × 1 （Q99460） 26S proteasome non-ATPase regulatory subunit 3 × 1 （O43242） 26S proteasome non-ATPase regulatory subunit 12 × 1 （O00232） 26S proteasome non-ATPase regulatory subunit 11 × 1 （O00231） 26S proteasome non-ATPase regulatory subunit 6 × 1 （Q15008） 26S proteasome non-ATPase regulatory subunit 7 × 1 （P51665） 26S proteasome non-ATPase regulatory subunit 13 × 1 （Q9UNM6） 26S proteasome non-ATPase regulatory subunit 4 × 1 （P55036） 26S proteasome non-ATPase regulatory subunit 14 × 1 （O00487） 26S proteasome non-ATPase regulatory subunit 8 × 1 （P48556） 26S proteasome complex subunit SEM1 × 1 （P60896） 26S proteasome non-ATPase regulatory subunit 2 × 1 （Q13200） 26S proteasome regulatory subunit 7 × 1 （P35998） 26S proteasome regulatory subunit 4 × 1 （P62191） 26S proteasome regulatory subunit 8 × 1 （P62195） 26S proteasome regulatory subunit 10B × 1 （A0A087X2I1） 26S proteasome regulatory subunit 6A × 1 （P17980） Ubiquitin × 1 （P0CG47） substrate × 1 Proteasome subunit alpha type-6 × 2 （P60900） Proteasome subunit alpha type-2 × 2 （P25787） Proteasome subunit alpha type-4 × 2 （P25789） Proteasome subunit alpha type-7 × 2 （O14818） Proteasome subunit alpha type-5 × 2 （P28066） Proteasome subunit alpha type-1 × 2 （P25786） Proteasome subunit alpha type-3 × 2 （P25788） Proteasome subunit beta type-6 × 2 （P28072） Proteasome subunit beta type-7 × 2 （Q99436） Proteasome subunit beta type-3 × 2 （P49720） Proteasome subunit beta type-2 × 2 （P49721） Proteasome subunit beta type-5 × 2 （P28074） Proteasome subunit beta type-1 × 2 （P20618） Proteasome subunit beta type-4 × 2 （P28070） ZINC ION × 1 ADENOSINE-5'-TRIPHOSPHATE × 3 MAGNESIUM ION × 3 ADENOSINE-5'-DIPHOSPHATE × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PRS6B_HUMAN
Isoform	—
PDB entities	16
Chains and sequence ranges	Author chain D； PDBConstruct 1–418； UniProt 1–418

26S proteasome regulatory subunit 10B

Homo sapiens

UniProt A0A087X2I1

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 48	26S proteasome non-ATPase regulatory subunit 1 × 1 （Q99460） 26S proteasome non-ATPase regulatory subunit 3 × 1 （O43242） 26S proteasome non-ATPase regulatory subunit 12 × 1 （O00232） 26S proteasome non-ATPase regulatory subunit 11 × 1 （O00231） 26S proteasome non-ATPase regulatory subunit 6 × 1 （Q15008） 26S proteasome non-ATPase regulatory subunit 7 × 1 （P51665） 26S proteasome non-ATPase regulatory subunit 13 × 1 （Q9UNM6） 26S proteasome non-ATPase regulatory subunit 4 × 1 （P55036） 26S proteasome non-ATPase regulatory subunit 14 × 1 （O00487） 26S proteasome non-ATPase regulatory subunit 8 × 1 （P48556） 26S proteasome complex subunit SEM1 × 1 （P60896） 26S proteasome non-ATPase regulatory subunit 2 × 1 （Q13200） 26S proteasome regulatory subunit 7 × 1 （P35998） 26S proteasome regulatory subunit 4 × 1 （P62191） 26S proteasome regulatory subunit 8 × 1 （P62195） 26S proteasome regulatory subunit 6B × 1 （P43686） 26S proteasome regulatory subunit 6A × 1 （P17980） Ubiquitin × 1 （P0CG47） substrate × 1 Proteasome subunit alpha type-6 × 2 （P60900） Proteasome subunit alpha type-2 × 2 （P25787） Proteasome subunit alpha type-4 × 2 （P25789） Proteasome subunit alpha type-7 × 2 （O14818） Proteasome subunit alpha type-5 × 2 （P28066） Proteasome subunit alpha type-1 × 2 （P25786） Proteasome subunit alpha type-3 × 2 （P25788） Proteasome subunit beta type-6 × 2 （P28072） Proteasome subunit beta type-7 × 2 （Q99436） Proteasome subunit beta type-3 × 2 （P49720） Proteasome subunit beta type-2 × 2 （P49721） Proteasome subunit beta type-5 × 2 （P28074） Proteasome subunit beta type-1 × 2 （P20618） Proteasome subunit beta type-4 × 2 （P28070） ZINC ION × 1 ADENOSINE-5'-TRIPHOSPHATE × 3 MAGNESIUM ION × 3 ADENOSINE-5'-DIPHOSPHATE × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	A0A087X2I1_HUMAN
Isoform	—
PDB entities	17
Chains and sequence ranges	Author chain E； PDBConstruct 1–403； UniProt 1–403

26S proteasome regulatory subunit 6A

Homo sapiens

UniProt P17980

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 48	26S proteasome non-ATPase regulatory subunit 1 × 1 （Q99460） 26S proteasome non-ATPase regulatory subunit 3 × 1 （O43242） 26S proteasome non-ATPase regulatory subunit 12 × 1 （O00232） 26S proteasome non-ATPase regulatory subunit 11 × 1 （O00231） 26S proteasome non-ATPase regulatory subunit 6 × 1 （Q15008） 26S proteasome non-ATPase regulatory subunit 7 × 1 （P51665） 26S proteasome non-ATPase regulatory subunit 13 × 1 （Q9UNM6） 26S proteasome non-ATPase regulatory subunit 4 × 1 （P55036） 26S proteasome non-ATPase regulatory subunit 14 × 1 （O00487） 26S proteasome non-ATPase regulatory subunit 8 × 1 （P48556） 26S proteasome complex subunit SEM1 × 1 （P60896） 26S proteasome non-ATPase regulatory subunit 2 × 1 （Q13200） 26S proteasome regulatory subunit 7 × 1 （P35998） 26S proteasome regulatory subunit 4 × 1 （P62191） 26S proteasome regulatory subunit 8 × 1 （P62195） 26S proteasome regulatory subunit 6B × 1 （P43686） 26S proteasome regulatory subunit 10B × 1 （A0A087X2I1） Ubiquitin × 1 （P0CG47） substrate × 1 Proteasome subunit alpha type-6 × 2 （P60900） Proteasome subunit alpha type-2 × 2 （P25787） Proteasome subunit alpha type-4 × 2 （P25789） Proteasome subunit alpha type-7 × 2 （O14818） Proteasome subunit alpha type-5 × 2 （P28066） Proteasome subunit alpha type-1 × 2 （P25786） Proteasome subunit alpha type-3 × 2 （P25788） Proteasome subunit beta type-6 × 2 （P28072） Proteasome subunit beta type-7 × 2 （Q99436） Proteasome subunit beta type-3 × 2 （P49720） Proteasome subunit beta type-2 × 2 （P49721） Proteasome subunit beta type-5 × 2 （P28074） Proteasome subunit beta type-1 × 2 （P20618） Proteasome subunit beta type-4 × 2 （P28070） ZINC ION × 1 ADENOSINE-5'-TRIPHOSPHATE × 3 MAGNESIUM ION × 3 ADENOSINE-5'-DIPHOSPHATE × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PRS6A_HUMAN
Isoform	—
PDB entities	18
Chains and sequence ranges	Author chain F； PDBConstruct 1–439； UniProt 1–439

Ubiquitin

Homo sapiens

UniProt P0CG47

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 48	26S proteasome non-ATPase regulatory subunit 1 × 1 （Q99460） 26S proteasome non-ATPase regulatory subunit 3 × 1 （O43242） 26S proteasome non-ATPase regulatory subunit 12 × 1 （O00232） 26S proteasome non-ATPase regulatory subunit 11 × 1 （O00231） 26S proteasome non-ATPase regulatory subunit 6 × 1 （Q15008） 26S proteasome non-ATPase regulatory subunit 7 × 1 （P51665） 26S proteasome non-ATPase regulatory subunit 13 × 1 （Q9UNM6） 26S proteasome non-ATPase regulatory subunit 4 × 1 （P55036） 26S proteasome non-ATPase regulatory subunit 14 × 1 （O00487） 26S proteasome non-ATPase regulatory subunit 8 × 1 （P48556） 26S proteasome complex subunit SEM1 × 1 （P60896） 26S proteasome non-ATPase regulatory subunit 2 × 1 （Q13200） 26S proteasome regulatory subunit 7 × 1 （P35998） 26S proteasome regulatory subunit 4 × 1 （P62191） 26S proteasome regulatory subunit 8 × 1 （P62195） 26S proteasome regulatory subunit 6B × 1 （P43686） 26S proteasome regulatory subunit 10B × 1 （A0A087X2I1） 26S proteasome regulatory subunit 6A × 1 （P17980） substrate × 1 Proteasome subunit alpha type-6 × 2 （P60900） Proteasome subunit alpha type-2 × 2 （P25787） Proteasome subunit alpha type-4 × 2 （P25789） Proteasome subunit alpha type-7 × 2 （O14818） Proteasome subunit alpha type-5 × 2 （P28066） Proteasome subunit alpha type-1 × 2 （P25786） Proteasome subunit alpha type-3 × 2 （P25788） Proteasome subunit beta type-6 × 2 （P28072） Proteasome subunit beta type-7 × 2 （Q99436） Proteasome subunit beta type-3 × 2 （P49720） Proteasome subunit beta type-2 × 2 （P49721） Proteasome subunit beta type-5 × 2 （P28074） Proteasome subunit beta type-1 × 2 （P20618） Proteasome subunit beta type-4 × 2 （P28070） ZINC ION × 1 ADENOSINE-5'-TRIPHOSPHATE × 3 MAGNESIUM ION × 3 ADENOSINE-5'-DIPHOSPHATE × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	UBB_HUMAN
Isoform	—
PDB entities	19
Chains and sequence ranges	Author chain u； PDBConstruct 1–76； UniProt 1–76

Proteasome subunit alpha type-6

Homo sapiens

UniProt P60900

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 48	26S proteasome non-ATPase regulatory subunit 1 × 1 （Q99460） 26S proteasome non-ATPase regulatory subunit 3 × 1 （O43242） 26S proteasome non-ATPase regulatory subunit 12 × 1 （O00232） 26S proteasome non-ATPase regulatory subunit 11 × 1 （O00231） 26S proteasome non-ATPase regulatory subunit 6 × 1 （Q15008） 26S proteasome non-ATPase regulatory subunit 7 × 1 （P51665） 26S proteasome non-ATPase regulatory subunit 13 × 1 （Q9UNM6） 26S proteasome non-ATPase regulatory subunit 4 × 1 （P55036） 26S proteasome non-ATPase regulatory subunit 14 × 1 （O00487） 26S proteasome non-ATPase regulatory subunit 8 × 1 （P48556） 26S proteasome complex subunit SEM1 × 1 （P60896） 26S proteasome non-ATPase regulatory subunit 2 × 1 （Q13200） 26S proteasome regulatory subunit 7 × 1 （P35998） 26S proteasome regulatory subunit 4 × 1 （P62191） 26S proteasome regulatory subunit 8 × 1 （P62195） 26S proteasome regulatory subunit 6B × 1 （P43686） 26S proteasome regulatory subunit 10B × 1 （A0A087X2I1） 26S proteasome regulatory subunit 6A × 1 （P17980） Ubiquitin × 1 （P0CG47） substrate × 1 Proteasome subunit alpha type-2 × 2 （P25787） Proteasome subunit alpha type-4 × 2 （P25789） Proteasome subunit alpha type-7 × 2 （O14818） Proteasome subunit alpha type-5 × 2 （P28066） Proteasome subunit alpha type-1 × 2 （P25786） Proteasome subunit alpha type-3 × 2 （P25788） Proteasome subunit beta type-6 × 2 （P28072） Proteasome subunit beta type-7 × 2 （Q99436） Proteasome subunit beta type-3 × 2 （P49720） Proteasome subunit beta type-2 × 2 （P49721） Proteasome subunit beta type-5 × 2 （P28074） Proteasome subunit beta type-1 × 2 （P20618） Proteasome subunit beta type-4 × 2 （P28070） ZINC ION × 1 ADENOSINE-5'-TRIPHOSPHATE × 3 MAGNESIUM ION × 3 ADENOSINE-5'-DIPHOSPHATE × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PSA6_HUMAN
Isoform	—
PDB entities	21
Chains and sequence ranges	Author chain G； PDBConstruct 1–245； UniProt 2–246 Author chain g； PDBConstruct 1–245； UniProt 2–246

Proteasome subunit alpha type-2

Homo sapiens

UniProt P25787

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 48	26S proteasome non-ATPase regulatory subunit 1 × 1 （Q99460） 26S proteasome non-ATPase regulatory subunit 3 × 1 （O43242） 26S proteasome non-ATPase regulatory subunit 12 × 1 （O00232） 26S proteasome non-ATPase regulatory subunit 11 × 1 （O00231） 26S proteasome non-ATPase regulatory subunit 6 × 1 （Q15008） 26S proteasome non-ATPase regulatory subunit 7 × 1 （P51665） 26S proteasome non-ATPase regulatory subunit 13 × 1 （Q9UNM6） 26S proteasome non-ATPase regulatory subunit 4 × 1 （P55036） 26S proteasome non-ATPase regulatory subunit 14 × 1 （O00487） 26S proteasome non-ATPase regulatory subunit 8 × 1 （P48556） 26S proteasome complex subunit SEM1 × 1 （P60896） 26S proteasome non-ATPase regulatory subunit 2 × 1 （Q13200） 26S proteasome regulatory subunit 7 × 1 （P35998） 26S proteasome regulatory subunit 4 × 1 （P62191） 26S proteasome regulatory subunit 8 × 1 （P62195） 26S proteasome regulatory subunit 6B × 1 （P43686） 26S proteasome regulatory subunit 10B × 1 （A0A087X2I1） 26S proteasome regulatory subunit 6A × 1 （P17980） Ubiquitin × 1 （P0CG47） substrate × 1 Proteasome subunit alpha type-6 × 2 （P60900） Proteasome subunit alpha type-4 × 2 （P25789） Proteasome subunit alpha type-7 × 2 （O14818） Proteasome subunit alpha type-5 × 2 （P28066） Proteasome subunit alpha type-1 × 2 （P25786） Proteasome subunit alpha type-3 × 2 （P25788） Proteasome subunit beta type-6 × 2 （P28072） Proteasome subunit beta type-7 × 2 （Q99436） Proteasome subunit beta type-3 × 2 （P49720） Proteasome subunit beta type-2 × 2 （P49721） Proteasome subunit beta type-5 × 2 （P28074） Proteasome subunit beta type-1 × 2 （P20618） Proteasome subunit beta type-4 × 2 （P28070） ZINC ION × 1 ADENOSINE-5'-TRIPHOSPHATE × 3 MAGNESIUM ION × 3 ADENOSINE-5'-DIPHOSPHATE × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PSA2_HUMAN
Isoform	—
PDB entities	22
Chains and sequence ranges	Author chain H； PDBConstruct 1–233； UniProt 2–234 Author chain h； PDBConstruct 1–233； UniProt 2–234

Proteasome subunit alpha type-4

Homo sapiens

UniProt P25789

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 48	26S proteasome non-ATPase regulatory subunit 1 × 1 （Q99460） 26S proteasome non-ATPase regulatory subunit 3 × 1 （O43242） 26S proteasome non-ATPase regulatory subunit 12 × 1 （O00232） 26S proteasome non-ATPase regulatory subunit 11 × 1 （O00231） 26S proteasome non-ATPase regulatory subunit 6 × 1 （Q15008） 26S proteasome non-ATPase regulatory subunit 7 × 1 （P51665） 26S proteasome non-ATPase regulatory subunit 13 × 1 （Q9UNM6） 26S proteasome non-ATPase regulatory subunit 4 × 1 （P55036） 26S proteasome non-ATPase regulatory subunit 14 × 1 （O00487） 26S proteasome non-ATPase regulatory subunit 8 × 1 （P48556） 26S proteasome complex subunit SEM1 × 1 （P60896） 26S proteasome non-ATPase regulatory subunit 2 × 1 （Q13200） 26S proteasome regulatory subunit 7 × 1 （P35998） 26S proteasome regulatory subunit 4 × 1 （P62191） 26S proteasome regulatory subunit 8 × 1 （P62195） 26S proteasome regulatory subunit 6B × 1 （P43686） 26S proteasome regulatory subunit 10B × 1 （A0A087X2I1） 26S proteasome regulatory subunit 6A × 1 （P17980） Ubiquitin × 1 （P0CG47） substrate × 1 Proteasome subunit alpha type-6 × 2 （P60900） Proteasome subunit alpha type-2 × 2 （P25787） Proteasome subunit alpha type-7 × 2 （O14818） Proteasome subunit alpha type-5 × 2 （P28066） Proteasome subunit alpha type-1 × 2 （P25786） Proteasome subunit alpha type-3 × 2 （P25788） Proteasome subunit beta type-6 × 2 （P28072） Proteasome subunit beta type-7 × 2 （Q99436） Proteasome subunit beta type-3 × 2 （P49720） Proteasome subunit beta type-2 × 2 （P49721） Proteasome subunit beta type-5 × 2 （P28074） Proteasome subunit beta type-1 × 2 （P20618） Proteasome subunit beta type-4 × 2 （P28070） ZINC ION × 1 ADENOSINE-5'-TRIPHOSPHATE × 3 MAGNESIUM ION × 3 ADENOSINE-5'-DIPHOSPHATE × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PSA4_HUMAN
Isoform	—
PDB entities	23
Chains and sequence ranges	Author chain I； PDBConstruct 1–260； UniProt 2–261 Author chain i； PDBConstruct 1–260； UniProt 2–261

Proteasome subunit alpha type-7

Homo sapiens

UniProt O14818

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 48	26S proteasome non-ATPase regulatory subunit 1 × 1 （Q99460） 26S proteasome non-ATPase regulatory subunit 3 × 1 （O43242） 26S proteasome non-ATPase regulatory subunit 12 × 1 （O00232） 26S proteasome non-ATPase regulatory subunit 11 × 1 （O00231） 26S proteasome non-ATPase regulatory subunit 6 × 1 （Q15008） 26S proteasome non-ATPase regulatory subunit 7 × 1 （P51665） 26S proteasome non-ATPase regulatory subunit 13 × 1 （Q9UNM6） 26S proteasome non-ATPase regulatory subunit 4 × 1 （P55036） 26S proteasome non-ATPase regulatory subunit 14 × 1 （O00487） 26S proteasome non-ATPase regulatory subunit 8 × 1 （P48556） 26S proteasome complex subunit SEM1 × 1 （P60896） 26S proteasome non-ATPase regulatory subunit 2 × 1 （Q13200） 26S proteasome regulatory subunit 7 × 1 （P35998） 26S proteasome regulatory subunit 4 × 1 （P62191） 26S proteasome regulatory subunit 8 × 1 （P62195） 26S proteasome regulatory subunit 6B × 1 （P43686） 26S proteasome regulatory subunit 10B × 1 （A0A087X2I1） 26S proteasome regulatory subunit 6A × 1 （P17980） Ubiquitin × 1 （P0CG47） substrate × 1 Proteasome subunit alpha type-6 × 2 （P60900） Proteasome subunit alpha type-2 × 2 （P25787） Proteasome subunit alpha type-4 × 2 （P25789） Proteasome subunit alpha type-5 × 2 （P28066） Proteasome subunit alpha type-1 × 2 （P25786） Proteasome subunit alpha type-3 × 2 （P25788） Proteasome subunit beta type-6 × 2 （P28072） Proteasome subunit beta type-7 × 2 （Q99436） Proteasome subunit beta type-3 × 2 （P49720） Proteasome subunit beta type-2 × 2 （P49721） Proteasome subunit beta type-5 × 2 （P28074） Proteasome subunit beta type-1 × 2 （P20618） Proteasome subunit beta type-4 × 2 （P28070） ZINC ION × 1 ADENOSINE-5'-TRIPHOSPHATE × 3 MAGNESIUM ION × 3 ADENOSINE-5'-DIPHOSPHATE × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PSA7_HUMAN
Isoform	—
PDB entities	24
Chains and sequence ranges	Author chain J； PDBConstruct 1–247； UniProt 2–248 Author chain j； PDBConstruct 1–247； UniProt 2–248

Proteasome subunit alpha type-5

Homo sapiens

UniProt P28066

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 48	26S proteasome non-ATPase regulatory subunit 1 × 1 （Q99460） 26S proteasome non-ATPase regulatory subunit 3 × 1 （O43242） 26S proteasome non-ATPase regulatory subunit 12 × 1 （O00232） 26S proteasome non-ATPase regulatory subunit 11 × 1 （O00231） 26S proteasome non-ATPase regulatory subunit 6 × 1 （Q15008） 26S proteasome non-ATPase regulatory subunit 7 × 1 （P51665） 26S proteasome non-ATPase regulatory subunit 13 × 1 （Q9UNM6） 26S proteasome non-ATPase regulatory subunit 4 × 1 （P55036） 26S proteasome non-ATPase regulatory subunit 14 × 1 （O00487） 26S proteasome non-ATPase regulatory subunit 8 × 1 （P48556） 26S proteasome complex subunit SEM1 × 1 （P60896） 26S proteasome non-ATPase regulatory subunit 2 × 1 （Q13200） 26S proteasome regulatory subunit 7 × 1 （P35998） 26S proteasome regulatory subunit 4 × 1 （P62191） 26S proteasome regulatory subunit 8 × 1 （P62195） 26S proteasome regulatory subunit 6B × 1 （P43686） 26S proteasome regulatory subunit 10B × 1 （A0A087X2I1） 26S proteasome regulatory subunit 6A × 1 （P17980） Ubiquitin × 1 （P0CG47） substrate × 1 Proteasome subunit alpha type-6 × 2 （P60900） Proteasome subunit alpha type-2 × 2 （P25787） Proteasome subunit alpha type-4 × 2 （P25789） Proteasome subunit alpha type-7 × 2 （O14818） Proteasome subunit alpha type-1 × 2 （P25786） Proteasome subunit alpha type-3 × 2 （P25788） Proteasome subunit beta type-6 × 2 （P28072） Proteasome subunit beta type-7 × 2 （Q99436） Proteasome subunit beta type-3 × 2 （P49720） Proteasome subunit beta type-2 × 2 （P49721） Proteasome subunit beta type-5 × 2 （P28074） Proteasome subunit beta type-1 × 2 （P20618） Proteasome subunit beta type-4 × 2 （P28070） ZINC ION × 1 ADENOSINE-5'-TRIPHOSPHATE × 3 MAGNESIUM ION × 3 ADENOSINE-5'-DIPHOSPHATE × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PSA5_HUMAN
Isoform	—
PDB entities	25
Chains and sequence ranges	Author chain K； PDBConstruct 1–240； UniProt 2–241 Author chain k； PDBConstruct 1–240； UniProt 2–241

Proteasome subunit alpha type-1

Homo sapiens

UniProt P25786

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 48	26S proteasome non-ATPase regulatory subunit 1 × 1 （Q99460） 26S proteasome non-ATPase regulatory subunit 3 × 1 （O43242） 26S proteasome non-ATPase regulatory subunit 12 × 1 （O00232） 26S proteasome non-ATPase regulatory subunit 11 × 1 （O00231） 26S proteasome non-ATPase regulatory subunit 6 × 1 （Q15008） 26S proteasome non-ATPase regulatory subunit 7 × 1 （P51665） 26S proteasome non-ATPase regulatory subunit 13 × 1 （Q9UNM6） 26S proteasome non-ATPase regulatory subunit 4 × 1 （P55036） 26S proteasome non-ATPase regulatory subunit 14 × 1 （O00487） 26S proteasome non-ATPase regulatory subunit 8 × 1 （P48556） 26S proteasome complex subunit SEM1 × 1 （P60896） 26S proteasome non-ATPase regulatory subunit 2 × 1 （Q13200） 26S proteasome regulatory subunit 7 × 1 （P35998） 26S proteasome regulatory subunit 4 × 1 （P62191） 26S proteasome regulatory subunit 8 × 1 （P62195） 26S proteasome regulatory subunit 6B × 1 （P43686） 26S proteasome regulatory subunit 10B × 1 （A0A087X2I1） 26S proteasome regulatory subunit 6A × 1 （P17980） Ubiquitin × 1 （P0CG47） substrate × 1 Proteasome subunit alpha type-6 × 2 （P60900） Proteasome subunit alpha type-2 × 2 （P25787） Proteasome subunit alpha type-4 × 2 （P25789） Proteasome subunit alpha type-7 × 2 （O14818） Proteasome subunit alpha type-5 × 2 （P28066） Proteasome subunit alpha type-3 × 2 （P25788） Proteasome subunit beta type-6 × 2 （P28072） Proteasome subunit beta type-7 × 2 （Q99436） Proteasome subunit beta type-3 × 2 （P49720） Proteasome subunit beta type-2 × 2 （P49721） Proteasome subunit beta type-5 × 2 （P28074） Proteasome subunit beta type-1 × 2 （P20618） Proteasome subunit beta type-4 × 2 （P28070） ZINC ION × 1 ADENOSINE-5'-TRIPHOSPHATE × 3 MAGNESIUM ION × 3 ADENOSINE-5'-DIPHOSPHATE × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PSA1_HUMAN
Isoform	P25786-2
PDB entities	26
Chains and sequence ranges	Author chain L； PDBConstruct 1–268； UniProt 2–269 Author chain l； PDBConstruct 1–268； UniProt 2–269

Proteasome subunit alpha type-3

Homo sapiens

UniProt P25788

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 48	26S proteasome non-ATPase regulatory subunit 1 × 1 （Q99460） 26S proteasome non-ATPase regulatory subunit 3 × 1 （O43242） 26S proteasome non-ATPase regulatory subunit 12 × 1 （O00232） 26S proteasome non-ATPase regulatory subunit 11 × 1 （O00231） 26S proteasome non-ATPase regulatory subunit 6 × 1 （Q15008） 26S proteasome non-ATPase regulatory subunit 7 × 1 （P51665） 26S proteasome non-ATPase regulatory subunit 13 × 1 （Q9UNM6） 26S proteasome non-ATPase regulatory subunit 4 × 1 （P55036） 26S proteasome non-ATPase regulatory subunit 14 × 1 （O00487） 26S proteasome non-ATPase regulatory subunit 8 × 1 （P48556） 26S proteasome complex subunit SEM1 × 1 （P60896） 26S proteasome non-ATPase regulatory subunit 2 × 1 （Q13200） 26S proteasome regulatory subunit 7 × 1 （P35998） 26S proteasome regulatory subunit 4 × 1 （P62191） 26S proteasome regulatory subunit 8 × 1 （P62195） 26S proteasome regulatory subunit 6B × 1 （P43686） 26S proteasome regulatory subunit 10B × 1 （A0A087X2I1） 26S proteasome regulatory subunit 6A × 1 （P17980） Ubiquitin × 1 （P0CG47） substrate × 1 Proteasome subunit alpha type-6 × 2 （P60900） Proteasome subunit alpha type-2 × 2 （P25787） Proteasome subunit alpha type-4 × 2 （P25789） Proteasome subunit alpha type-7 × 2 （O14818） Proteasome subunit alpha type-5 × 2 （P28066） Proteasome subunit alpha type-1 × 2 （P25786） Proteasome subunit beta type-6 × 2 （P28072） Proteasome subunit beta type-7 × 2 （Q99436） Proteasome subunit beta type-3 × 2 （P49720） Proteasome subunit beta type-2 × 2 （P49721） Proteasome subunit beta type-5 × 2 （P28074） Proteasome subunit beta type-1 × 2 （P20618） Proteasome subunit beta type-4 × 2 （P28070） ZINC ION × 1 ADENOSINE-5'-TRIPHOSPHATE × 3 MAGNESIUM ION × 3 ADENOSINE-5'-DIPHOSPHATE × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PSA3_HUMAN
Isoform	—
PDB entities	27
Chains and sequence ranges	Author chain M； PDBConstruct 1–254； UniProt 2–255 Author chain m； PDBConstruct 1–254； UniProt 2–255

Proteasome subunit beta type-6

Homo sapiens

UniProt P28072

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 48	26S proteasome non-ATPase regulatory subunit 1 × 1 （Q99460） 26S proteasome non-ATPase regulatory subunit 3 × 1 （O43242） 26S proteasome non-ATPase regulatory subunit 12 × 1 （O00232） 26S proteasome non-ATPase regulatory subunit 11 × 1 （O00231） 26S proteasome non-ATPase regulatory subunit 6 × 1 （Q15008） 26S proteasome non-ATPase regulatory subunit 7 × 1 （P51665） 26S proteasome non-ATPase regulatory subunit 13 × 1 （Q9UNM6） 26S proteasome non-ATPase regulatory subunit 4 × 1 （P55036） 26S proteasome non-ATPase regulatory subunit 14 × 1 （O00487） 26S proteasome non-ATPase regulatory subunit 8 × 1 （P48556） 26S proteasome complex subunit SEM1 × 1 （P60896） 26S proteasome non-ATPase regulatory subunit 2 × 1 （Q13200） 26S proteasome regulatory subunit 7 × 1 （P35998） 26S proteasome regulatory subunit 4 × 1 （P62191） 26S proteasome regulatory subunit 8 × 1 （P62195） 26S proteasome regulatory subunit 6B × 1 （P43686） 26S proteasome regulatory subunit 10B × 1 （A0A087X2I1） 26S proteasome regulatory subunit 6A × 1 （P17980） Ubiquitin × 1 （P0CG47） substrate × 1 Proteasome subunit alpha type-6 × 2 （P60900） Proteasome subunit alpha type-2 × 2 （P25787） Proteasome subunit alpha type-4 × 2 （P25789） Proteasome subunit alpha type-7 × 2 （O14818） Proteasome subunit alpha type-5 × 2 （P28066） Proteasome subunit alpha type-1 × 2 （P25786） Proteasome subunit alpha type-3 × 2 （P25788） Proteasome subunit beta type-7 × 2 （Q99436） Proteasome subunit beta type-3 × 2 （P49720） Proteasome subunit beta type-2 × 2 （P49721） Proteasome subunit beta type-5 × 2 （P28074） Proteasome subunit beta type-1 × 2 （P20618） Proteasome subunit beta type-4 × 2 （P28070） ZINC ION × 1 ADENOSINE-5'-TRIPHOSPHATE × 3 MAGNESIUM ION × 3 ADENOSINE-5'-DIPHOSPHATE × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PSB6_HUMAN
Isoform	—
PDB entities	28
Chains and sequence ranges	Author chain N； PDBConstruct 1–238； UniProt 2–239 Author chain n； PDBConstruct 1–238； UniProt 2–239

Proteasome subunit beta type-7

Homo sapiens

UniProt Q99436

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 48	26S proteasome non-ATPase regulatory subunit 1 × 1 （Q99460） 26S proteasome non-ATPase regulatory subunit 3 × 1 （O43242） 26S proteasome non-ATPase regulatory subunit 12 × 1 （O00232） 26S proteasome non-ATPase regulatory subunit 11 × 1 （O00231） 26S proteasome non-ATPase regulatory subunit 6 × 1 （Q15008） 26S proteasome non-ATPase regulatory subunit 7 × 1 （P51665） 26S proteasome non-ATPase regulatory subunit 13 × 1 （Q9UNM6） 26S proteasome non-ATPase regulatory subunit 4 × 1 （P55036） 26S proteasome non-ATPase regulatory subunit 14 × 1 （O00487） 26S proteasome non-ATPase regulatory subunit 8 × 1 （P48556） 26S proteasome complex subunit SEM1 × 1 （P60896） 26S proteasome non-ATPase regulatory subunit 2 × 1 （Q13200） 26S proteasome regulatory subunit 7 × 1 （P35998） 26S proteasome regulatory subunit 4 × 1 （P62191） 26S proteasome regulatory subunit 8 × 1 （P62195） 26S proteasome regulatory subunit 6B × 1 （P43686） 26S proteasome regulatory subunit 10B × 1 （A0A087X2I1） 26S proteasome regulatory subunit 6A × 1 （P17980） Ubiquitin × 1 （P0CG47） substrate × 1 Proteasome subunit alpha type-6 × 2 （P60900） Proteasome subunit alpha type-2 × 2 （P25787） Proteasome subunit alpha type-4 × 2 （P25789） Proteasome subunit alpha type-7 × 2 （O14818） Proteasome subunit alpha type-5 × 2 （P28066） Proteasome subunit alpha type-1 × 2 （P25786） Proteasome subunit alpha type-3 × 2 （P25788） Proteasome subunit beta type-6 × 2 （P28072） Proteasome subunit beta type-3 × 2 （P49720） Proteasome subunit beta type-2 × 2 （P49721） Proteasome subunit beta type-5 × 2 （P28074） Proteasome subunit beta type-1 × 2 （P20618） Proteasome subunit beta type-4 × 2 （P28070） ZINC ION × 1 ADENOSINE-5'-TRIPHOSPHATE × 3 MAGNESIUM ION × 3 ADENOSINE-5'-DIPHOSPHATE × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PSB7_HUMAN
Isoform	—
PDB entities	29
Chains and sequence ranges	Author chain O； PDBConstruct 1–276； UniProt 2–277 Author chain o； PDBConstruct 1–276； UniProt 2–277

Proteasome subunit beta type-3

Homo sapiens

UniProt P49720

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 48	26S proteasome non-ATPase regulatory subunit 1 × 1 （Q99460） 26S proteasome non-ATPase regulatory subunit 3 × 1 （O43242） 26S proteasome non-ATPase regulatory subunit 12 × 1 （O00232） 26S proteasome non-ATPase regulatory subunit 11 × 1 （O00231） 26S proteasome non-ATPase regulatory subunit 6 × 1 （Q15008） 26S proteasome non-ATPase regulatory subunit 7 × 1 （P51665） 26S proteasome non-ATPase regulatory subunit 13 × 1 （Q9UNM6） 26S proteasome non-ATPase regulatory subunit 4 × 1 （P55036） 26S proteasome non-ATPase regulatory subunit 14 × 1 （O00487） 26S proteasome non-ATPase regulatory subunit 8 × 1 （P48556） 26S proteasome complex subunit SEM1 × 1 （P60896） 26S proteasome non-ATPase regulatory subunit 2 × 1 （Q13200） 26S proteasome regulatory subunit 7 × 1 （P35998） 26S proteasome regulatory subunit 4 × 1 （P62191） 26S proteasome regulatory subunit 8 × 1 （P62195） 26S proteasome regulatory subunit 6B × 1 （P43686） 26S proteasome regulatory subunit 10B × 1 （A0A087X2I1） 26S proteasome regulatory subunit 6A × 1 （P17980） Ubiquitin × 1 （P0CG47） substrate × 1 Proteasome subunit alpha type-6 × 2 （P60900） Proteasome subunit alpha type-2 × 2 （P25787） Proteasome subunit alpha type-4 × 2 （P25789） Proteasome subunit alpha type-7 × 2 （O14818） Proteasome subunit alpha type-5 × 2 （P28066） Proteasome subunit alpha type-1 × 2 （P25786） Proteasome subunit alpha type-3 × 2 （P25788） Proteasome subunit beta type-6 × 2 （P28072） Proteasome subunit beta type-7 × 2 （Q99436） Proteasome subunit beta type-2 × 2 （P49721） Proteasome subunit beta type-5 × 2 （P28074） Proteasome subunit beta type-1 × 2 （P20618） Proteasome subunit beta type-4 × 2 （P28070） ZINC ION × 1 ADENOSINE-5'-TRIPHOSPHATE × 3 MAGNESIUM ION × 3 ADENOSINE-5'-DIPHOSPHATE × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PSB3_HUMAN
Isoform	—
PDB entities	30
Chains and sequence ranges	Author chain P； PDBConstruct 1–204； UniProt 2–205 Author chain p； PDBConstruct 1–204； UniProt 2–205

Proteasome subunit beta type-2

Homo sapiens

UniProt P49721

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 48	26S proteasome non-ATPase regulatory subunit 1 × 1 （Q99460） 26S proteasome non-ATPase regulatory subunit 3 × 1 （O43242） 26S proteasome non-ATPase regulatory subunit 12 × 1 （O00232） 26S proteasome non-ATPase regulatory subunit 11 × 1 （O00231） 26S proteasome non-ATPase regulatory subunit 6 × 1 （Q15008） 26S proteasome non-ATPase regulatory subunit 7 × 1 （P51665） 26S proteasome non-ATPase regulatory subunit 13 × 1 （Q9UNM6） 26S proteasome non-ATPase regulatory subunit 4 × 1 （P55036） 26S proteasome non-ATPase regulatory subunit 14 × 1 （O00487） 26S proteasome non-ATPase regulatory subunit 8 × 1 （P48556） 26S proteasome complex subunit SEM1 × 1 （P60896） 26S proteasome non-ATPase regulatory subunit 2 × 1 （Q13200） 26S proteasome regulatory subunit 7 × 1 （P35998） 26S proteasome regulatory subunit 4 × 1 （P62191） 26S proteasome regulatory subunit 8 × 1 （P62195） 26S proteasome regulatory subunit 6B × 1 （P43686） 26S proteasome regulatory subunit 10B × 1 （A0A087X2I1） 26S proteasome regulatory subunit 6A × 1 （P17980） Ubiquitin × 1 （P0CG47） substrate × 1 Proteasome subunit alpha type-6 × 2 （P60900） Proteasome subunit alpha type-2 × 2 （P25787） Proteasome subunit alpha type-4 × 2 （P25789） Proteasome subunit alpha type-7 × 2 （O14818） Proteasome subunit alpha type-5 × 2 （P28066） Proteasome subunit alpha type-1 × 2 （P25786） Proteasome subunit alpha type-3 × 2 （P25788） Proteasome subunit beta type-6 × 2 （P28072） Proteasome subunit beta type-7 × 2 （Q99436） Proteasome subunit beta type-3 × 2 （P49720） Proteasome subunit beta type-5 × 2 （P28074） Proteasome subunit beta type-1 × 2 （P20618） Proteasome subunit beta type-4 × 2 （P28070） ZINC ION × 1 ADENOSINE-5'-TRIPHOSPHATE × 3 MAGNESIUM ION × 3 ADENOSINE-5'-DIPHOSPHATE × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PSB2_HUMAN
Isoform	—
PDB entities	31
Chains and sequence ranges	Author chain Q； PDBConstruct 1–201； UniProt 1–201 Author chain q； PDBConstruct 1–201； UniProt 1–201

Proteasome subunit beta type-5

Homo sapiens

UniProt P28074

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 48	26S proteasome non-ATPase regulatory subunit 1 × 1 （Q99460） 26S proteasome non-ATPase regulatory subunit 3 × 1 （O43242） 26S proteasome non-ATPase regulatory subunit 12 × 1 （O00232） 26S proteasome non-ATPase regulatory subunit 11 × 1 （O00231） 26S proteasome non-ATPase regulatory subunit 6 × 1 （Q15008） 26S proteasome non-ATPase regulatory subunit 7 × 1 （P51665） 26S proteasome non-ATPase regulatory subunit 13 × 1 （Q9UNM6） 26S proteasome non-ATPase regulatory subunit 4 × 1 （P55036） 26S proteasome non-ATPase regulatory subunit 14 × 1 （O00487） 26S proteasome non-ATPase regulatory subunit 8 × 1 （P48556） 26S proteasome complex subunit SEM1 × 1 （P60896） 26S proteasome non-ATPase regulatory subunit 2 × 1 （Q13200） 26S proteasome regulatory subunit 7 × 1 （P35998） 26S proteasome regulatory subunit 4 × 1 （P62191） 26S proteasome regulatory subunit 8 × 1 （P62195） 26S proteasome regulatory subunit 6B × 1 （P43686） 26S proteasome regulatory subunit 10B × 1 （A0A087X2I1） 26S proteasome regulatory subunit 6A × 1 （P17980） Ubiquitin × 1 （P0CG47） substrate × 1 Proteasome subunit alpha type-6 × 2 （P60900） Proteasome subunit alpha type-2 × 2 （P25787） Proteasome subunit alpha type-4 × 2 （P25789） Proteasome subunit alpha type-7 × 2 （O14818） Proteasome subunit alpha type-5 × 2 （P28066） Proteasome subunit alpha type-1 × 2 （P25786） Proteasome subunit alpha type-3 × 2 （P25788） Proteasome subunit beta type-6 × 2 （P28072） Proteasome subunit beta type-7 × 2 （Q99436） Proteasome subunit beta type-3 × 2 （P49720） Proteasome subunit beta type-2 × 2 （P49721） Proteasome subunit beta type-1 × 2 （P20618） Proteasome subunit beta type-4 × 2 （P28070） ZINC ION × 1 ADENOSINE-5'-TRIPHOSPHATE × 3 MAGNESIUM ION × 3 ADENOSINE-5'-DIPHOSPHATE × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PSB5_HUMAN
Isoform	—
PDB entities	32
Chains and sequence ranges	Author chain R； PDBConstruct 1–262； UniProt 2–263 Author chain r； PDBConstruct 1–262； UniProt 2–263

Proteasome subunit beta type-1

Homo sapiens

UniProt P20618

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 48	26S proteasome non-ATPase regulatory subunit 1 × 1 （Q99460） 26S proteasome non-ATPase regulatory subunit 3 × 1 （O43242） 26S proteasome non-ATPase regulatory subunit 12 × 1 （O00232） 26S proteasome non-ATPase regulatory subunit 11 × 1 （O00231） 26S proteasome non-ATPase regulatory subunit 6 × 1 （Q15008） 26S proteasome non-ATPase regulatory subunit 7 × 1 （P51665） 26S proteasome non-ATPase regulatory subunit 13 × 1 （Q9UNM6） 26S proteasome non-ATPase regulatory subunit 4 × 1 （P55036） 26S proteasome non-ATPase regulatory subunit 14 × 1 （O00487） 26S proteasome non-ATPase regulatory subunit 8 × 1 （P48556） 26S proteasome complex subunit SEM1 × 1 （P60896） 26S proteasome non-ATPase regulatory subunit 2 × 1 （Q13200） 26S proteasome regulatory subunit 7 × 1 （P35998） 26S proteasome regulatory subunit 4 × 1 （P62191） 26S proteasome regulatory subunit 8 × 1 （P62195） 26S proteasome regulatory subunit 6B × 1 （P43686） 26S proteasome regulatory subunit 10B × 1 （A0A087X2I1） 26S proteasome regulatory subunit 6A × 1 （P17980） Ubiquitin × 1 （P0CG47） substrate × 1 Proteasome subunit alpha type-6 × 2 （P60900） Proteasome subunit alpha type-2 × 2 （P25787） Proteasome subunit alpha type-4 × 2 （P25789） Proteasome subunit alpha type-7 × 2 （O14818） Proteasome subunit alpha type-5 × 2 （P28066） Proteasome subunit alpha type-1 × 2 （P25786） Proteasome subunit alpha type-3 × 2 （P25788） Proteasome subunit beta type-6 × 2 （P28072） Proteasome subunit beta type-7 × 2 （Q99436） Proteasome subunit beta type-3 × 2 （P49720） Proteasome subunit beta type-2 × 2 （P49721） Proteasome subunit beta type-5 × 2 （P28074） Proteasome subunit beta type-4 × 2 （P28070） ZINC ION × 1 ADENOSINE-5'-TRIPHOSPHATE × 3 MAGNESIUM ION × 3 ADENOSINE-5'-DIPHOSPHATE × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PSB1_HUMAN
Isoform	—
PDB entities	33
Chains and sequence ranges	Author chain S； PDBConstruct 1–240； UniProt 2–241 Author chain s； PDBConstruct 1–240； UniProt 2–241

Proteasome subunit beta type-4

Homo sapiens

UniProt P28070

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 48	26S proteasome non-ATPase regulatory subunit 1 × 1 （Q99460） 26S proteasome non-ATPase regulatory subunit 3 × 1 （O43242） 26S proteasome non-ATPase regulatory subunit 12 × 1 （O00232） 26S proteasome non-ATPase regulatory subunit 11 × 1 （O00231） 26S proteasome non-ATPase regulatory subunit 6 × 1 （Q15008） 26S proteasome non-ATPase regulatory subunit 7 × 1 （P51665） 26S proteasome non-ATPase regulatory subunit 13 × 1 （Q9UNM6） 26S proteasome non-ATPase regulatory subunit 4 × 1 （P55036） 26S proteasome non-ATPase regulatory subunit 14 × 1 （O00487） 26S proteasome non-ATPase regulatory subunit 8 × 1 （P48556） 26S proteasome complex subunit SEM1 × 1 （P60896） 26S proteasome non-ATPase regulatory subunit 2 × 1 （Q13200） 26S proteasome regulatory subunit 7 × 1 （P35998） 26S proteasome regulatory subunit 4 × 1 （P62191） 26S proteasome regulatory subunit 8 × 1 （P62195） 26S proteasome regulatory subunit 6B × 1 （P43686） 26S proteasome regulatory subunit 10B × 1 （A0A087X2I1） 26S proteasome regulatory subunit 6A × 1 （P17980） Ubiquitin × 1 （P0CG47） substrate × 1 Proteasome subunit alpha type-6 × 2 （P60900） Proteasome subunit alpha type-2 × 2 （P25787） Proteasome subunit alpha type-4 × 2 （P25789） Proteasome subunit alpha type-7 × 2 （O14818） Proteasome subunit alpha type-5 × 2 （P28066） Proteasome subunit alpha type-1 × 2 （P25786） Proteasome subunit alpha type-3 × 2 （P25788） Proteasome subunit beta type-6 × 2 （P28072） Proteasome subunit beta type-7 × 2 （Q99436） Proteasome subunit beta type-3 × 2 （P49720） Proteasome subunit beta type-2 × 2 （P49721） Proteasome subunit beta type-5 × 2 （P28074） Proteasome subunit beta type-1 × 2 （P20618） ZINC ION × 1 ADENOSINE-5'-TRIPHOSPHATE × 3 MAGNESIUM ION × 3 ADENOSINE-5'-DIPHOSPHATE × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PSB4_HUMAN
Isoform	—
PDB entities	34
Chains and sequence ranges	Author chain T； PDBConstruct 1–263； UniProt 2–264 Author chain t； PDBConstruct 1–263； UniProt 2–264

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id	6mse
Deposition date deposition_date	2018-10-16
Structure title title	Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome
Keywords keywords	Proteosome, HYDROLASE; HYDROLASE
Experimental Method method	ELECTRON MICROSCOPY

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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

6mse__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

6mse__assembly_1__model_1 | I(q)

100 plotted points; both axes use logarithmic scales.

6mse__assembly_1__model_1 | P(r) · Pending

P(r) will be calculated and displayed separately for the same assembly/model.

Rg（Guinier）	97.10 Å
Rg (electron density)	98.10 Å
Total Rg	97.91 Å
Atom count	105062
Residues	13506
Excluded volume	1873000 Å³
Maximum q	0.500 Å⁻¹

Assembly	Model	Structure unit	Oligomeric description	Status	CRYSOL	Actions
1	1	`6mse__assembly_1__model_1`	48-meric （48）	Success	4.1.3-1-20251215 (887e7ef)	View Download

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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (38)

Entity 1 Entity 1 polymer

Description description	26S proteasome non-ATPase regulatory subunit 1
Molecular weight formula_weight	105958.2 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	U
Atom count atom_count	105062

MITSAAGIISLLDEDEPQLKEFALHKLNAVVNDFWAEISESVDKIEVLYEDEGFRSRQFAALVASKVFYHLGAFEESLNYALGAGDLFNVNDNSEYVETIIAKCIDHYTKQCVENADLPEGEKKPIDQRLEGIVNKMFQRCLDDHKYKQAIGIALETRRLDVFEKTILESNDVPGMLAYSLKLCMSLMQNKQFRNKVLRVLVKIYMNLEKPDFINVCQCLIFLDDPQAVSDILEKLVKEDNLLMAYQICFDLYESASQQFLSSVIQNLRTVGTPIASVPGSTNTGTVPGSEKDSDSMETEEKTSSAFVGKTPEASPEPKDQTLKMIKILSGEMAIELHLQFLIRNNNTDLMILKNTKDAVRNSVCHTATVIANSFMHCGTTSDQFLRDNLEWLARATNWAKFTATASLGVIHKGHEKEALQLMATYLPKDTSPGSAYQEGGGLYALGLIHANHGGDIIDYLLNQLKNASNDIVRHGGSLGLGLAAMGTARQDVYDLLKTNLYQDDAVTGEAAGLALGLVMLGSKNAQAIEDMVGYAQETQHEKILRGLAVGIALVMYGRMEEADALIESLCRDKDPILRRSGMYTVAMAYCGSGNNKAIRRLLHVAVSDVNDDVRRAAVESLGFILFRTPEQCPSVVSLLSESYNPHVRYGAAMALGICCAGTGNKEAINLLEPMTNDPVNYVRQGALIASALIMIQQTEITCPKVNQFRQLYSKVINDKHDDVMAKFGAILAQGILDAGGHNVTISLQSRTGHTHMPSVVGVLVFTQFWFWFPLSHFLSLAYTPTCVIGLNKDLKMPKVQYKSNCKPSTFAYPAPLEVPKEKEKEKVSTAVLSITAKAKKKEKEKEKKEEEKMEVDEAEKKEEKEKKKEPEPNFQLLDNPARVMPAQLKVLTMPETCRYQPFKPLSIGGIIILKDTSEDIEELVEPVAAHGPKIEEEEQEPEPPEPFEYIDD

Source Source

Source organism organism	Homo sapiens
Common name common_name	Human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Homo sapiens

Entity 2 Entity 2 polymer

Description description	26S proteasome non-ATPase regulatory subunit 3
Molecular weight formula_weight	60935.3 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	V

KQEGSARRRGADKAKPPPGGGEQEPPPPPAPQDVEMKEEAATGGGSTGEADGKTAAAAAEHSQRELDTVTLEDIKEHVKQLEKAVSGKEPRFVLRALRMLPSTSRRLNHYVLYKAVQGFFTSNNATRDFLLPFLEEPMDTEADLQFRPRTGKAASTPLLPEVEAYLQLLVVIFMMNSKRYKEAQKISDDLMQKISTQNRRALDLVAAKCYYYHARVYEFLDKLDVVRSFLHARLRTATLRHDADGQATLLNLLLRNYLHYSLYDQAEKLVSKSVFPEQANNNEWARYLYYTGRIKAIQLEYSEARRTMTNALRKAPQHTAVGFKQTVHKLLIVVELLLGEIPDRLQFRQPSLKRSLMPYFLLTQAVRTGNLAKFNQVLDQFGEKFQADGTYTLIIRLRHNVIKTGVRMISLSYSRISLADIAQKLQLDSPEDAEFIVAKAIRDGVIEASINHEKGYVQSKEMIDIYSTREPQLAFHQRISFCLDIHNMSVKAMRFPPKSYNKDLESAEERREREQQDLEFAKEMAEDDDDSFP

Source Source

Source organism organism	Homo sapiens
Common name common_name	Human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Homo sapiens

Entity 3 Entity 3 polymer

Description description	26S proteasome non-ATPase regulatory subunit 12
Molecular weight formula_weight	52979.4 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	W

MADGGSERADGRIVKMEVDYSATVDQRLPECAKLAKEGRLQEVIETLLSLEKQTRTASDMVSTSRILVAVVKMCYEAKEWDLLNENIMLLSKRRSQLKQAVAKMVQQCCTYVEEITDLPIKLRLIDTLRMVTEGKIYVEIERARLTKTLATIKEQNGDVKEAASILQELQVETYGSMEKKERVEFILEQMRLCLAVKDYIRTQIISKKINTKFFQEENTEKLKLKYYNLMIQLDQHEGSYLSICKHYRAIYDTPCIQAESEKWQQALKSVVLYVILAPFDNEQSDLVHRISGDKKLEEIPKYKDLLKLFTTMELMRWSTLVEDYGMELRKGSLESPATDVFGSTEEGEKRWKDLKNRVVEHNIRIMAKYYTRITMKRMAQLLDLSVDESEAFLSNLVVNKTIFAKVDRLAGIINFQRPKDPNNLLNDWSQKLNSLMSLVNKTTHLIAKEEMIHNLQ

Source Source

Source organism organism	Homo sapiens
Common name common_name	Human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Homo sapiens

Entity 4 Entity 4 polymer

Description description	26S proteasome non-ATPase regulatory subunit 11
Molecular weight formula_weight	47526.7 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	X

MAAAAVVEFQRAQSLLSTDREASIDILHSIVKRDIQENDEEAVQVKEQSILELGSLLAKTGQAAELGGLLKYVRPFLNSISKAKAARLVRSLLDLFLDMEAATGQEVELCLECIEWAKSEKRTFLRQALEARLVSLYFDTKRYQEALHLGSQLLRELKKMDDKALLVEVQLLESKTYHALSNLPKARAALTSARTTANAIYCPPKLQATLDMQSGIIHAAEEKDWKTAYSYFYEAFEGYDSIDSPKAITSLKYMLLCKIMLNTPEDVQALVSGKLALRYAGRQTEALKCVAQASKNRSLADFEKALTDYRAELRDDPIISTHLAKLYDNLLEQNLIRVIEPFSRVQIEHISSLIKLSKADVERKLSQMILDKKFHGILDQGEGVLIIFDEPPVDKTYEAALETIQNMSKVVDSLYNKAKKLT

Source Source

Source organism organism	Homo sapiens
Common name common_name	Human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Homo sapiens

Entity 5 Entity 5 polymer

Description description	26S proteasome non-ATPase regulatory subunit 6
Molecular weight formula_weight	45592.3 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	Y

MPLENLEEEGLPKNPDLRIAQLRFLLSLPEHRGDAAVRDELMAAVRDNNMAPYYEALCKSLDWQIDVDLLNKMKKANEDELKRLDEELEDAEKNLGESEIRDAMMAKAEYLCRIGDKEGALTAFRKTYDKTVALGHRLDIVFYLLRIGLFYMDNDLITRNTEKAKSLIEEGGDWDRRNRLKVYQGLYCVAIRDFKQAAELFLDTVSTFTSYELMDYKTFVTYTVYVSMIALERPDLREKVIKGAEILEVLHSLPAVRQYLFSLYECRYSVFFQSLAVVEQEMKKDWLFAPHYRYYVREMRIHAYSQLLESYRSLTLGYMAEAFGVGVEFIDQELSRFIAAGRLHCKIDKVNEIVETNRPDSKNWQYQETIKKGDLLLNRVQKLSRVINM

Source Source

Source organism organism	Homo sapiens
Common name common_name	Human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Homo sapiens

Entity 6 Entity 6 polymer

Description description	26S proteasome non-ATPase regulatory subunit 7
Molecular weight formula_weight	37086.4 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	Z

MPELAVQKVVVHPLVLLSVVDHFNRIGKVGNQKRVVGVLLGSWQKKVLDVSNSFAVPFDEDDKDDSVWFLDHDYLENMYGMFKKVNARERIVGWYHTGPKLHKNDIAINELMKRYCPNSVLVIIDVKPKDLGLPTEAYISVEEVHDDGTPTSKTFEHVTSEIGAEEAEEVGVEHLLRDIKDTTVGTLSQRITNQVHGLKGLNSKLLDIRSYLEKVATGKLPINHQIIYQLQDVFNLLPDVSLQEFVKAFYLKTNDQMVVVYLASLIRSVVALHNLINNKIANRDAEKKEGQEKEESKKDRKEDKEKDKDKEKSDVKKEEKKEKK

Source Source

Source organism organism	Homo sapiens
Common name common_name	Human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Homo sapiens

Entity 7 Entity 7 polymer

Description description	26S proteasome non-ATPase regulatory subunit 13
Molecular weight formula_weight	42995.4 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	a

MKDVPGFLQQSQNSGPGQPAVWHRLEELYTKKLWHQLTLQVLDFVQDPCFAQGDGLIKLYENFISEFEHRVNPLSLVEIILHVVRQMTDPNVALTFLEKTREKVKSSDEAVILCKTAIGALKLNIGDLQVTKETIEDVEEMLNNLPGVTSVHSRFYDLSSKYYQTIGNHASYYKDALRFLGCVDIKDLPVSEQQERAFTLGLAGLLGEGVFNFGELLMHPVLESLRNTDRQWLIDTLYAFNSGNVERFQTLKTAWGQQPDLAANEAQLLRKIQLLCLMEMTFTRPANHRQLTFEEIAKSAKITVNEVELLVMKALSVGLVKGSIDEVDKRVHMTWVQPRVLDLQQIKGMKDRLEFWCTDVKSMEMLVEHQAHDILT

Source Source

Source organism organism	Homo sapiens
Common name common_name	Human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Homo sapiens

Entity 8 Entity 8 polymer

Description description	26S proteasome non-ATPase regulatory subunit 4
Molecular weight formula_weight	40781.6 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	b

MVLESTMVCVDNSEYMRNGDFLPTRLQAQQDAVNIVCHSKTRSNPENNVGLITLANDCEVLTTLTPDTGRILSKLHTVQPKGKITFCTGIRVAHLALKHRQGKNHKMRIIAFVGSPVEDNEKDLVKLAKRLKKEKVNVDIINFGEEEVNTEKLTAFVNTLNGKDGTGSHLVTVPPGPSLADALISSPILAGEGGAMLGLGASDFEFGVDPSADPELALALRVSMEEQRQRQEEEARRAAAASAAEAGIATTGTEDSDDALLKMTISQQEFGRTGLPDLSSMTEEEQIAYAMQMSLQGAEFGQAESADIDASSAMDTSEPAKEEDDYDVMQDPEFLQSVLENLPGVDPNNEAIRNAMGSLASQATKDGKKDKKEEDKK

Source Source

Source organism organism	Homo sapiens
Common name common_name	Human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Homo sapiens

Entity 9 Entity 9 polymer

Description description	26S proteasome non-ATPase regulatory subunit 14
Molecular weight formula_weight	34488.8 kDa
EC 编号 ec_number	3.4.19.-
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	c

DRLLRLGGGMPGLGQGPPTDAPAVDTAEQVYISSLALLKMLKHGRAGVPMEVMGLMLGEFVDDYTVRVIDVFAMPQSGTGVSVEAVDPVFQAKMLDMLKQTGRPEMVVGWYHSHPGFGCWLSGVDINTQQSFEALSERAVAVVVDPIQSVKGKVVIDAFRLINANMMVLGHEPRQTTSNLGHLNKPSIQALIHGLNRHYYSITINYRKNELEQKMLLNLHKKSWMEGLTLQDYSEHCKHNESVVKEMLELAKNYNKAVEEEDKMTPEQLAIKNVGKQDPKRHLEEHVDVLMTSNIVQCLAAMLDTVVFK

Source Source

Source organism organism	Homo sapiens
Common name common_name	Human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Homo sapiens

Entity 10 Entity 10 polymer

Description description	26S proteasome non-ATPase regulatory subunit 8
Molecular weight formula_weight	39536.7 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	d

FIKGRAPRAPPRERRRATRGGLRQVVAPPRALGSTSRPHFRRASVCRRRCRKSGGLLAASRKMAAAAVNGAAGFSSSGPAATSGAVLQAATGMYEQLKGEWNRKSPNLSKCGEELGRLKLVLLELNFLPTTGTKLTKQQLILARDILEIGAQWSILRKDIPSFERYMAQLKCYYFDYKEQLPESAYMHQLLGLNLLFLLSQNRVAEFHTELERLPAKDIQTNVYIKHPVSLEQYLMEGSYNKVFLAKGNIPAESYTFFIDILLDTIRDEIAGCIEKAYEKILFTEATRILFFNTPKKMTDYAKKRGWVLGPNNYYSFASQQQKPEDTTIPSTELAKQVIEYARQLEMIV

Source Source

Source organism organism	Homo sapiens
Common name common_name	Human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Homo sapiens

Entity 11 Entity 11 polymer

Description description	26S proteasome complex subunit SEM1
Molecular weight formula_weight	8284.6 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	e

MSEKKQPVDLGLLEEDDEFEEFPAEDWAGLDEDEDAHVWEDNWDDDNVEDDFSNQLRAELEKHGYKMETS

Source Source

Source organism organism	Homo sapiens
Common name common_name	Human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Homo sapiens

Entity 12 Entity 12 polymer

Description description	26S proteasome non-ATPase regulatory subunit 2
Molecular weight formula_weight	98425.4 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	f

MEEGGRDKAPVQPQQSPAAAPGGTDEKPSGKERRDAGDKDKEQELSEEDKQLQDELEMLVERLGEKDTSLYRPALEELRRQIRSSTTSMTSVPKPLKFLRPHYGKLKEIYENMAPGENKRFAADIISVLAMTMSGERECLKYRLVGSQEELASWGHEYVRHLAGEVAKEWQELDDAEKVQREPLLTLVKEIVPYNMAHNAEHEACDLLMEIEQVDMLEKDIDENAYAKVCLYLTSCVNYVPEPENSALLRCALGVFRKFSRFPEALRLALMLNDMELVEDIFTSCKDVVVQKQMAFMLGRHGVFLELSEDVEEYEDLTEIMSNVQLNSNFLALARELDIMEPKVPDDIYKTHLENNRFGGSGSQVDSARMNLASSFVNGFVNAAFGQDKLLTDDGNKWLYKNKDHGMLSAAASLGMILLWDVDGGLTQIDKYLYSSEDYIKSGALLACGIVNSGVRNECDPALALLSDYVLHNSNTMRLGSIFGLGLAYAGSNREDVLTLLLPVMGDSKSSMEVAGVTALACGMIAVGSCNGDVTSTILQTIMEKSETELKDTYARWLPLGLGLNHLGKGEAIEAILAALEVVSEPFRSFANTLVDVCAYAGSGNVLKVQQLLHICSEHFDSKEKEEDKDKKEKKDKDKKEAPADMGAHQGVAVLGIALIAMGEEIGAEMALRTFGHLLRYGEPTLRRAVPLALALISVSNPRLNILDTLSKFSHDADPEVSYNSIFAMGMVGSGTNNARLAAMLRQLAQYHAKDPNNLFMVRLAQGLTHLGKGTLTLCPYHSDRQLMSQVAVAGLLTVLVSFLDVRNIILGKSHYVLYGLVAAMQPRMLVTFDEELRPLPVSVRVGQAVDVVGQAGKPKTITGFQTHTTPVLLAHGERAELATEEFLPVTP

Source Source

Source organism organism	Homo sapiens
Common name common_name	Human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Homo sapiens

Entity 13 Entity 13 polymer

Description description	26S proteasome regulatory subunit 7
Molecular weight formula_weight	48700.8 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	A

MPDYLGADQRKTKEDEKDDKPIRALDEGDIALLKTYGQSTYSRQIKQVEDDIQQLLKKINELTGIKESDTGLAPPALWDLAADKQTLQSEQPLQVARCTKIINADSEDPKYIINVKQFAKFVVDLSDQVAPTDIEEGMRVGVDRNKYQIHIPLPPKIDPTVTMMQVEEKPDVTYSDVGGCKEQIEKLREVVETPLLHPERFVNLGIEPPKGVLLFGPPGTGKTLCARAVANRTDACFIRVIGSELVQKYVGEGARMVRELFEMARTKKACLIFFDEIDAIGGARFDDGAGGDNEVQRTMLELINQLDGFDPRGNIKVLMATNRPDTLDPALMRPGRLDRKIEFSLPDLEGRTHIFKIHARSMSVERDIRFELLARLCPNSTGAEIRSVCTEAGMFAIRARRKIATEKDFLEAVNKVIKSYAKFSATPRYMTYN

Source Source

Source organism organism	Homo sapiens
Common name common_name	Human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Homo sapiens

Entity 14 Entity 14 polymer

Description description	26S proteasome regulatory subunit 4
Molecular weight formula_weight	49260.5 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	B

MGQSQSGGHGPGGGKKDDKDKKKKYEPPVPTRVGKKKKKTKGPDAASKLPLVTPHTQCRLKLLKLERIKDYLLMEEEFIRNQEQMKPLEEKQEEERSKVDDLRGTPMSVGTLEEIIDDNHAIVSTSVGSEHYVSILSFVDKDLLEPGCSVLLNHKVHAVIGVLMDDTDPLVTVMKVEKAPQETYADIGGLDNQIQEIKESVELPLTHPEYYEEMGIKPPKGVILYGPPGTGKTLLAKAVANQTSATFLRVVGSELIQKYLGDGPKLVRELFRVAEEHAPSIVFIDEIDAIGTKRYDSNSGGEREIQRTMLELLNQLDGFDSRGDVKVIMATNRIETLDPALIRPGRIDRKIEFPLPDEKTKKRIFQIHTSRMTLADDVTLDDLIMAKDDLSGADIKAICTEAGLMALRERRMKVTNEDFKKSKENVLYKKQEGTPEGLYL

Source Source

Source organism organism	Homo sapiens
Common name common_name	Human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Homo sapiens

Entity 15 Entity 15 polymer

Description description	26S proteasome regulatory subunit 8
Molecular weight formula_weight	44852.1 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	C

MELEEGKAGSGLRQYYLSKIEELQLIVNDKSQNLRRLQAQRNELNAKVRLLREELQLLQEQGSYVGEVVRAMDKKKVLVKVHPEGKFVVDVDKNIDINDVTPNCRVALRNDSYTLHKILPNKVDPLVSLMMVEKVPDSTYEMIGGLDKQIKEIKEVIELPVKHPELFEALGIAQPKGVLLYGPPGTGKTLLARAVAHHTDCTFIRVSGSELVQKFIGEGARMVRELFVMAREHAPSIIFMDEIDSIGSSRLEGGSGGDSEVQRTMLELLNQLDGFEATKNIKVIMATNRIDILDSALLRPGRIDRKIEFPPPNEEARLDILKIHSRKMNLTRGINLRKIAELMPGASGAEVKGVCTEAGMYALRERRVHVTQEDFEMAVAKVMQKDSEKNMSIKKLWK

Source Source

Source organism organism	Homo sapiens
Common name common_name	Human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Homo sapiens

Entity 16 Entity 16 polymer

Description description	26S proteasome regulatory subunit 6B
Molecular weight formula_weight	47426.1 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	D

MEEIGILVEKAQDEIPALSVSRPQTGLSFLGPEPEDLEDLYSRYKKLQQELEFLEVQEEYIKDEQKNLKKEFLHAQEEVKRIQSIPLVIGQFLEAVDQNTAIVGSTTGSNYYVRILSTIDRELLKPNASVALHKHSNALVDVLPPEADSSIMMLTSDQKPDVMYADIGGMDIQKQEVREAVELPLTHFELYKQIGIDPPRGVLMYGPPGCGKTMLAKAVAHHTTAAFIRVVGSEFVQKYLGEGPRMVRDVFRLAKENAPAIIFIDEIDAIATKRFDAQTGADREVQRILLELLNQMDGFDQNVNVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDRRQKRLIFSTITSKMNLSEEVDLEDYVARPDKISGADINSICQESGMLAVRENRYIVLAKDFEKAYKTVIKKDEQEHEFYK

Source Source

Source organism organism	Homo sapiens
Common name common_name	Human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Homo sapiens

Entity 17 Entity 17 polymer

Description description	26S proteasome regulatory subunit 10B
Molecular weight formula_weight	45867.0 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	E

MAIPGIPYERRLLIMADPRDKALQDYRKKLLEHKEIDGRLKELREQLKELTKQYEKSENDLKALQSVGQIVGEVLKQLTEEKFIVKATNGPRYVVGCRRQLDKSKLKPGTRVALDMTTLTIMRYLPREVDPLVYNMSHEDPGNVSYSEIGGLSEQIRELREVIELPLTNPELFQRVGIIPPKGCLLYGPPGTGKTLLARAVASQLDCNFLKVVSSSIVDKYIGESARLIREMFNYARDHQPCIIFMDEIDAIGGRRFSEGTSADREIQRTLMELLNQMDGFDTLHRVKMIMATNRPDTLDPALLRPGRLDRKIHIDLPNEQARLDILKIHAGPITKHGEIDYEAIVKLSDGFNGADLRNVCTEAGMFAIRADHDFVVQEDFMKAVRKVADSKKLESKLDYKPV

Source Source

Source organism organism	Homo sapiens
Common name common_name	Human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Homo sapiens

Entity 18 Entity 18 polymer

Description description	26S proteasome regulatory subunit 6A
Molecular weight formula_weight	49266.5 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	F

MNLLPNIESPVTRQEKMATVWDEAEQDGIGEEVLKMSTEEIIQRTRLLDSEIKIMKSEVLRVTHELQAMKDKIKENSEKIKVNKTLPYLVSNVIELLDVDPNDQEEDGANIDLDSQRKGKCAVIKTSTRQTYFLPVIGLVDAEKLKPGDLVGVNKDSYLILETLPTEYDSRVKAMEVDERPTEQYSDIGGLDKQIQELVEAIVLPMNHKEKFENLGIQPPKGVLMYGPPGTGKTLLARACAAQTKATFLKLAGPQLVQMFIGDGAKLVRDAFALAKEKAPSIIFIDELDAIGTKRFDSEKAGDREVQRTMLELLNQLDGFQPNTQVKVIAATNRVDILDPALLRSGRLDRKIEFPMPNEEARARIMQIHSRKMNVSPDVNYEELARCTDDFNGAQCKAVCVEAGMIALRRGATELTHEDYMEGILEVQAKKKANLQYYA

Source Source

Source organism organism	Homo sapiens
Common name common_name	Human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Homo sapiens

Entity 19 Entity 19 polymer

Description description	Ubiquitin
Molecular weight formula_weight	8604.8 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	u

MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQRESTLHLVLRLRGG

Source Source

Source organism organism	Homo sapiens
Common name common_name	Human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Homo sapiens

Entity 20 Entity 20 polymer

Description description	substrate
Molecular weight formula_weight	2445.0 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	v

XXXXXXXXXXXXXXXXXXXXXXXXKXXX

Source Source

Source organism organism	Saccharomyces cerevisiae RM11-1a
Common name common_name	Yeast
NCBI taxonomy ID ncbi_taxonomy_id	285006
Host organism host_organism	Escherichia coli O103:H2 str. 12009

Entity 21 Entity 21 polymer

Description description	Proteasome subunit alpha type-6
Molecular weight formula_weight	27301.3 kDa
EC 编号 ec_number	3.4.25.1
Source method src_method	man
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	G,g

SRGSSAGFDRHITIFSPEGRLYQVEYAFKAINQGGLTSVAVRGKDCAVIVTQKKVPDKLLDSSTVTHLFKITENIGCVMTGMTADSRSQVQRARYEAANWKYKYGYEIPVDMLCKRIADISQVYTQNAEMRPLGCCMILIGIDEEQGPQVYKCDPAGYYCGFKATAAGVKQTESTSFLEKKVKKKFDWTFEQTVETAITCLSTVLSIDFKPSEIEVGVVTVENPKFRILTEAEIDAHLVALAERD

Source Source

Source organism organism	Homo sapiens
Common name common_name	Human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Homo sapiens

Entity 22 Entity 22 polymer

Description description	Proteasome subunit alpha type-2
Molecular weight formula_weight	25796.3 kDa
EC 编号 ec_number	3.4.25.1
Source method src_method	man
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	H,h

AERGYSFSLTTFSPSGKLVQIEYALAAVAGGAPSVGIKAANGVVLATEKKQKSILYDERSVHKVEPITKHIGLVYSGMGPDYRVLVHRARKLAQQYYLVYQEPIPTAQLVQRVASVMQEYTQSGGVRPFGVSLLICGWNEGRPYLFQSDPSGAYFAWKATAMGKNYVNGKTFLEKRYNEDLELEDAIHTAILTLKESFEGQMTEDNIEVGICNEAGFRRLTPTEVKDYLAAIA

Source Source

Source organism organism	Homo sapiens
Common name common_name	Human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Homo sapiens

Entity 23 Entity 23 polymer

Description description	Proteasome subunit alpha type-4
Molecular weight formula_weight	29394.6 kDa
EC 编号 ec_number	3.4.25.1
Source method src_method	man
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	I,i

SRRYDSRTTIFSPEGRLYQVEYAMEAIGHAGTCLGILANDGVLLAAERRNIHKLLDEVFFSEKIYKLNEDMACSVAGITSDANVLTNELRLIAQRYLLQYQEPIPCEQLVTALCDIKQAYTQFGGKRPFGVSLLYIGWDKHYGFQLYQSDPSGNYGGWKATCIGNNSAAAVSMLKQDYKEGEMTLKSALALAIKVLNKTMDVSKLSAEKVEIATLTRENGKTVIRVLKQKEVEQLIKKHEEEEAKAEREKKEKEQKEKDK

Source Source

Source organism organism	Homo sapiens
Common name common_name	Human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Homo sapiens

Entity 24 Entity 24 polymer

Description description	Proteasome subunit alpha type-7
Molecular weight formula_weight	27798.7 kDa
EC 编号 ec_number	3.4.25.1
Source method src_method	man
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	J,j

SYDRAITVFSPDGHLFQVEYAQEAVKKGSTAVGVRGRDIVVLGVEKKSVAKLQDERTVRKICALDDNVCMAFAGLTADARIVINRARVECQSHRLTVEDPVTVEYITRYIASLKQRYTQSNGRRPFGISALIVGFDFDGTPRLYQTDPSGTYHAWKANAIGRGAKSVREFLEKNYTDEAIETDDLTIKLVIKALLEVVQSGGKNIELAVMRRDQSLKILNPEEIEKYVAEIEKEKEENEKKKQKKAS

Source Source

Source organism organism	Homo sapiens
Common name common_name	Human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Homo sapiens

Entity 25 Entity 25 polymer

Description description	Proteasome subunit alpha type-5
Molecular weight formula_weight	26304.8 kDa
EC 编号 ec_number	3.4.25.1
Source method src_method	man
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	K,k

FLTRSEYDRGVNTFSPEGRLFQVEYAIEAIKLGSTAIGIQTSEGVCLAVEKRITSPLMEPSSIEKIVEIDAHIGCAMSGLIADAKTLIDKARVETQNHWFTYNETMTVESVTQAVSNLALQFGEEDADPGAMSRPFGVALLFGGVDEKGPQLFHMDPSGTFVQCDARAIGSASEGAQSSLQEVYHKSMTLKEAIKSSLIILKQVMEEKLNATNIELATVQPGQNFHMFTKEELEEVIKDI

Source Source

Source organism organism	Homo sapiens
Common name common_name	Human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Homo sapiens

Entity 26 Entity 26 polymer

Description description	Proteasome subunit alpha type-1
Molecular weight formula_weight	30150.3 kDa
EC 编号 ec_number	3.4.25.1
Source method src_method	man
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	L,l

QLSKVKFRNQYDNDVTVWSPQGRIHQIEYAMEAVKQGSATVGLKSKTHAVLVALKRAQSELAAHQKKILHVDNHIGISIAGLTADARLLCNFMRQECLDSRFVFDRPLPVSRLVSLIGSKTQIPTQRYGRRPYGVGLLIAGYDDMGPHIFQTCPSANYFDCRAMSIGARSQSARTYLERHMSEFMECNLNELVKHGLRALRETLPAEQDLTTKNVSIGIVGKDLEFTIYDDDDVSPFLEGLEERPQRKAQPAQPADEPAEKADEPMEH

Source Source

Source organism organism	Homo sapiens
Common name common_name	Human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Homo sapiens

Entity 27 Entity 27 polymer

Description description	Proteasome subunit alpha type-3
Molecular weight formula_weight	28338.1 kDa
EC 编号 ec_number	3.4.25.1
Source method src_method	man
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	M,m

SSIGTGYDLSASTFSPDGRVFQVEYAMKAVENSSTAIGIRCKDGVVFGVEKLVLSKLYEEGSNKRLFNVDRHVGMAVAGLLADARSLADIAREEASNFRSNFGYNIPLKHLADRVAMYVHAYTLYSAVRPFGCSFMLGSYSVNDGAQLYMIDPSGVSYGYWGCAIGKARQAAKTEIEKLQMKEMTCRDIVKEVAKIIYIVHDEVKDKAFELELSWVGELTNGRHEIVPKDIREEAEKYAKESLKEEDESDDDNM

Source Source

Source organism organism	Homo sapiens
Common name common_name	Human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Homo sapiens

Entity 28 Entity 28 polymer

Description description	Proteasome subunit beta type-6
Molecular weight formula_weight	25246.5 kDa
EC 编号 ec_number	3.4.25.1
Source method src_method	man
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	N,n

AATLLAARGAGPAPAWGPEAFTPDWESREVSTGTTIMAVQFDGGVVLGADSRTTTGSYIANRVTDKLTPIHDRIFCCRSGSAADTQAVADAVTYQLGFHSIELNEPPLVHTAASLFKEMCYRYREDLMAGIIIAGWDPQEGGQVYSVPMGGMMVRQSFAIGGSGSSYIYGYVDATYREGMTKEECLQFTANALALAMERDGSSGGVIRLAAIAESGVERQVLLGDQIPKFAVATLPPA

Source Source

Source organism organism	Homo sapiens
Common name common_name	Human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Homo sapiens

Entity 29 Entity 29 polymer

Description description	Proteasome subunit beta type-7
Molecular weight formula_weight	29869.2 kDa
EC 编号 ec_number	3.4.25.1
Source method src_method	man
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	O,o

AAVSVYAPPVGGFSFDNCRRNAVLEADFAKRGYKLPKVRKTGTTIAGVVYKDGIVLGADTRATEGMVVADKNCSKIHFISPNIYCCGAGTAADTDMTTQLISSNLELHSLSTGRLPRVVTANRMLKQMLFRYQGYIGAALVLGGVDVTGPHLYSIYPHGSTDKLPYVTMGSGSLAAMAVFEDKFRPDMEEEEAKNLVSEAIAAGIFNDLGSGSNIDLCVISKNKLDFLRPYTVPNKKGTRLGRYRCEKGTTAVLTEKITPLEIEVLEETVQTMDTS

Source Source

Source organism organism	Homo sapiens
Common name common_name	Human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Homo sapiens

Entity 30 Entity 30 polymer

Description description	Proteasome subunit beta type-3
Molecular weight formula_weight	22841.7 kDa
EC 编号 ec_number	3.4.25.1
Source method src_method	man
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	P,p

SIMSYNGGAVMAMKGKNCVAIAADRRFGIQAQMVTTDFQKIFPMGDRLYIGLAGLATDVQTVAQRLKFRLNLYELKEGRQIKPYTLMSMVANLLYEKRFGPYYTEPVIAGLDPKTFKPFICSLDLIGCPMVTDDFVVSGTCAEQMYGMCESLWEPNMDPDHLFETISQAMLNAVDRDAVSGMGVIVHIIEKDKITTRTLKARMD

Source Source

Source organism organism	Homo sapiens
Common name common_name	Human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Homo sapiens

Entity 31 Entity 31 polymer

Description description	Proteasome subunit beta type-2
Molecular weight formula_weight	22864.3 kDa
EC 编号 ec_number	3.4.25.1
Source method src_method	man
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	Q,q

MEYLIGIQGPDYVLVASDRVAASNIVQMKDDHDKMFKMSEKILLLCVGEAGDTVQFAEYIQKNVQLYKMRNGYELSPTAAANFTRRNLADCLRSRTPYHVNLLLAGYDEHEGPALYYMDYLAALAKAPFAAHGYGAFLTLSILDRYYTPTISRERAVELLRKCLEELQKRFILNLPTFSVRIIDKNGIHDLDNISFPKQGS

Source Source

Source organism organism	Homo sapiens
Common name common_name	Human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Homo sapiens

Entity 32 Entity 32 polymer

Description description	Proteasome subunit beta type-5
Molecular weight formula_weight	28379.1 kDa
EC 编号 ec_number	3.4.25.1
Source method src_method	man
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	R,r

ALASVLERPLPVNQRGFFGLGGRADLLDLGPGSLSDGLSLAAPGWGVPEEPGIEMLHGTTTLAFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLARQCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRISGATFSVGSGSVYAYGVMDRGYSYDLEVEQAYDLARRAIYQATYRDAYSGGAVNLYHVREDGWIRVSSDNVADLHEKYSGSTP

Source Source

Source organism organism	Homo sapiens
Common name common_name	Human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Homo sapiens

Entity 33 Entity 33 polymer

Description description	Proteasome subunit beta type-1
Molecular weight formula_weight	26391.2 kDa
EC 编号 ec_number	3.4.25.1
Source method src_method	man
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	S,s

LSSTAMYSAPGRDLGMEPHRAAGPLQLRFSPYVFNGGTILAIAGEDFAIVASDTRLSEGFSIHTRDSPKCYKLTDKTVIGCSGFHGDCLTLTKIIEARLKMYKHSNNKAMTTGAIAAMLSTILYSRRFFPYYVYNIIGGLDEEGKGAVYSFDPVGSYQRDSFKAGGSASAMLQPLLDNQVGFKNMQNVEHVPLSLDRAMRLVKDVFISAAERDVYTGDALRICIVTKEGIREETVSLRKD

Source Source

Source organism organism	Homo sapiens
Common name common_name	Human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Homo sapiens

Entity 34 Entity 34 polymer

Description description	Proteasome subunit beta type-4
Molecular weight formula_weight	29100.0 kDa
EC 编号 ec_number	3.4.25.1
Source method src_method	man
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	T,t

EAFLGSRSGLWAGGPAPGQFYRIPSTPDSFMDPASALYRGPITRTQNPMVTGTSVLGVKFEGGVVIAADMLGSYGSLARFRNISRIMRVNNSTMLGASGDYADFQYLKQVLGQMVIDEELLGDGHSYSPRAIHSWLTRAMYSRRSKMNPLWNTMVIGGYADGESFLGYVDMLGVAYEAPSLATGYGAYLAQPLLREVLEKQPVLSQTEARDLVERCMRVLYYRDARSYNRFQIATVTEKGVEIEGPLSTETNWDIAHMISGFE

Source Source

Source organism organism	Homo sapiens
Common name common_name	Human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Homo sapiens

Entity 35 Entity 35 non-polymer

Description description	ZINC ION
Molecular weight formula_weight	65.4 kDa
Source method src_method	syn
Copy count entity_count	1

Entity 36 Entity 36 non-polymer

Description description	ADENOSINE-5'-TRIPHOSPHATE
Molecular weight formula_weight	507.2 kDa
Source method src_method	syn
Copy count entity_count	3

Entity 37 Entity 37 non-polymer

Description description	MAGNESIUM ION
Molecular weight formula_weight	24.3 kDa
Source method src_method	syn
Copy count entity_count	3

Entity 38 Entity 38 non-polymer

Description description	ADENOSINE-5'-DIPHOSPHATE
Molecular weight formula_weight	427.2 kDa
Source method src_method	syn
Copy count entity_count	2

▶

Resolution resolution	3.30 Å
Resolution测定Method resolution_method	—
颗粒数 num_particles	242965

Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome

1. Protein Identity and Related Structures Protein Identity & Related Structures

26S proteasome non-ATPase regulatory subunit 1

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

26S proteasome non-ATPase regulatory subunit 3

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

26S proteasome non-ATPase regulatory subunit 12

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

26S proteasome non-ATPase regulatory subunit 11

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

26S proteasome non-ATPase regulatory subunit 6

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

26S proteasome non-ATPase regulatory subunit 7

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

26S proteasome non-ATPase regulatory subunit 13

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

26S proteasome non-ATPase regulatory subunit 4

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

26S proteasome non-ATPase regulatory subunit 14

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

26S proteasome non-ATPase regulatory subunit 8

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer