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6mwc

CryoEM structure of chimeric Eastern Equine Encephalitis Virus with Fab of EEEV-5 antibody

Method: ELECTRON MICROSCOPY
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1. Protein Identity and Related Structures Protein Identity & Related Structures

E1

Eastern equine encephalitis virus

UniProt E9KXM2

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 960 E2 × 240 （E9KXL2） EEEV-5 antibody heavy chain × 240 EEEV-5 antibody light chain × 240 （G0YP42） Consistent with protein count
2 Protein heterocomplex Heteromer Protein 16 E2 × 4 （E9KXL2） EEEV-5 antibody heavy chain × 4 EEEV-5 antibody light chain × 4 （G0YP42） Consistent with protein count
3 Protein heterocomplex Heteromer Protein 80 E2 × 20 （E9KXL2） EEEV-5 antibody heavy chain × 20 EEEV-5 antibody light chain × 20 （G0YP42） Consistent with protein count
4 Protein heterocomplex Heteromer Protein 96 E2 × 24 （E9KXL2） EEEV-5 antibody heavy chain × 24 EEEV-5 antibody light chain × 24 （G0YP42） Consistent with protein count
5 Protein heterocomplex Heteromer Protein 16 E2 × 4 （E9KXL2） EEEV-5 antibody heavy chain × 4 EEEV-5 antibody light chain × 4 （G0YP42） Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
6mui 6mui 6mui 6mui 6mui 6mw9 6mw9 6mw9 6mw9 6mw9 6mwc 6mwc

38 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name E9KXM2_EEEV
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–441； UniProt 802–1242 Author chain E； PDBConstruct 1–441； UniProt 802–1242 Author chain I； PDBConstruct 1–441； UniProt 802–1242 Author chain M； PDBConstruct 1–441； UniProt 802–1242

E2

Eastern equine encephalitis virus

UniProt E9KXL2

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 960 E1 × 240 （E9KXM2） EEEV-5 antibody heavy chain × 240 EEEV-5 antibody light chain × 240 （G0YP42） Consistent with protein count
2 Protein heterocomplex Heteromer Protein 16 E1 × 4 （E9KXM2） EEEV-5 antibody heavy chain × 4 EEEV-5 antibody light chain × 4 （G0YP42） Consistent with protein count
3 Protein heterocomplex Heteromer Protein 80 E1 × 20 （E9KXM2） EEEV-5 antibody heavy chain × 20 EEEV-5 antibody light chain × 20 （G0YP42） Consistent with protein count
4 Protein heterocomplex Heteromer Protein 96 E1 × 24 （E9KXM2） EEEV-5 antibody heavy chain × 24 EEEV-5 antibody light chain × 24 （G0YP42） Consistent with protein count
5 Protein heterocomplex Heteromer Protein 16 E1 × 4 （E9KXM2） EEEV-5 antibody heavy chain × 4 EEEV-5 antibody light chain × 4 （G0YP42） Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
6mui 6mui 6mui 6mui 6mui 6mw9 6mw9 6mw9 6mw9 6mw9 6mwc 6mwc

39 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name E9KXL2_EEEV
Isoform —
PDB entities 2
Chains and sequence ranges Author chain B； PDBConstruct 1–420； UniProt 325–744 Author chain F； PDBConstruct 1–420； UniProt 325–744 Author chain J； PDBConstruct 1–420； UniProt 325–744 Author chain N； PDBConstruct 1–420； UniProt 325–744

EEEV-5 antibody light chain

OrganismNot specified

UniProt G0YP42

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 960 E1 × 240 （E9KXM2） E2 × 240 （E9KXL2） EEEV-5 antibody heavy chain × 240 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 16 E1 × 4 （E9KXM2） E2 × 4 （E9KXL2） EEEV-5 antibody heavy chain × 4 Consistent with protein count
3 Protein heterocomplex Heteromer Protein 80 E1 × 20 （E9KXM2） E2 × 20 （E9KXL2） EEEV-5 antibody heavy chain × 20 Consistent with protein count
4 Protein heterocomplex Heteromer Protein 96 E1 × 24 （E9KXM2） E2 × 24 （E9KXL2） EEEV-5 antibody heavy chain × 24 Consistent with protein count
5 Protein heterocomplex Heteromer Protein 16 E1 × 4 （E9KXM2） E2 × 4 （E9KXL2） EEEV-5 antibody heavy chain × 4 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
6mui 6mui 6mui 6mui 6mui 6mw9 6mw9 6mw9 6mw9 6mw9 6mwc 6mwc

26 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name G0YP42_MOUSE
Isoform —
PDB entities 4
Chains and sequence ranges Author chain D； PDBConstruct 98–214； UniProt 117–233 Author chain H； PDBConstruct 98–214； UniProt 117–233 Author chain L； PDBConstruct 98–214； UniProt 117–233 Author chain P； PDBConstruct 98–214； UniProt 117–233

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id6mwc
Deposition date deposition_date2018-10-29
Structure title titleCryoEM structure of chimeric Eastern Equine Encephalitis Virus with Fab of EEEV-5 antibody
Keywords keywordsAlphavirus, EEEV, Eastern Equine Encephalitis Virus, Sindbis, Fab, VIRUS-IMMUNE SYSTEM complex; VIRUS/IMMUNE SYSTEM
Experimental Method methodELECTRON MICROSCOPY
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

6mwc__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

6mwc__assembly_1__model_1 | I(q)

10-2 10-1 105 106 107 108 109 1010 1011 1012 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

6mwc__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）0.00 Å
Rg (electron density)311.70 Å
Total Rg311.80 Å
Atom count2131680
Residues276960
Excluded volume37730000 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 6mwc__assembly_1__model_1 960-meric （960） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 6mwc__assembly_2__model_1 hexadecameric （16） Excluded — —
Exclusion reason： Auxiliary symmetry representation; not a complete or representative biological assembly.
3 1 6mwc__assembly_3__model_1 80-meric （80） Excluded — —
Exclusion reason： Auxiliary symmetry representation; not a complete or representative biological assembly.
4 1 6mwc__assembly_4__model_1 96-meric （96） Excluded — —
Exclusion reason： Auxiliary symmetry representation; not a complete or representative biological assembly.
5 1 6mwc__assembly_5__model_1 hexadecameric （16） Excluded — —
Exclusion reason： Auxiliary symmetry representation; not a complete or representative biological assembly.
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (4)

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7. Citations (1)