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6vo5

Crystal structure of Human histone acetytransferas 1 (HAT1) in complex with isobutryl-COA and K12A mutant variant of histone H4

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Histone acetyltransferase type B catalytic subunit

Homo sapiens

UniProt O14929

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 2 Histone H4 × 1 （P62805） ACETATE ION × 1 ISOBUTYRYL-COENZYME A × 1 GLYCEROL × 1 SULFATE ION × 1 UNKNOWN ATOM OR ION × 9 water × 2 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 2 Histone H4 × 1 （P62805） ISOBUTYRYL-COENZYME A × 1 GLYCEROL × 2 SULFATE ION × 1 UNKNOWN ATOM OR ION × 7 water × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
2p0w 2p0w 6vo5 6vo5

4 assemblies

View Construct and Data Evidence
UniProt name HAT1_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 3–324； UniProt 20–341 Author chain B； PDBConstruct 3–324； UniProt 20–341

Histone H4

OrganismNot specified

UniProt P62805

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 2 Histone acetyltransferase type B catalytic subunit × 1 （O14929） ACETATE ION × 1 ISOBUTYRYL-COENZYME A × 1 GLYCEROL × 1 SULFATE ION × 1 UNKNOWN ATOM OR ION × 9 water × 2 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 2 Histone acetyltransferase type B catalytic subunit × 1 （O14929） ISOBUTYRYL-COENZYME A × 1 GLYCEROL × 2 SULFATE ION × 1 UNKNOWN ATOM OR ION × 7 water × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
10xz 10ya 10yb 10yc 10yd 10ye 10yf 10yg 10yh 10yi 2bqz 2bqz

634 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name H4_HUMAN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain C； PDBConstruct 1–20； UniProt 2–21 Author chain D； PDBConstruct 1–20； UniProt 2–21

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id6vo5
Deposition date deposition_date2020-01-30
Structure title titleCrystal structure of Human histone acetytransferas 1 (HAT1) in complex with isobutryl-COA and K12A mutant variant of histone H4
Keywords keywordsHAT1, histone acetyltransferase 1, Isobutyryl-CoA, Structural Genomics, Structural Genomics Consortium, SGC, TRANSFERASE; TRANSFERASE
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 6vo5__assembly_1__model_1 dimeric （2） Excluded — —
Exclusion reason： The source record does not identify the atom or ion element unambiguously, so a reliable calculation is not possible.
2 1 6vo5__assembly_2__model_1 dimeric （2） Excluded — —
Exclusion reason： The source record does not identify the atom or ion element unambiguously, so a reliable calculation is not possible.
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (8)

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7. Citations (1)