7a6h

Cryo-EM structure of human apo RNA Polymerase III

Method: ELECTRON MICROSCOPY

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1. Protein Identity and Related Structures Protein Identity & Related Structures

DNA-directed RNA polymerase III subunit RPC1

OrganismNot specified

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 17	DNA-directed RNA polymerase III subunit RPC2 × 1 （Q9NW08） DNA-directed RNA polymerases I and III subunit RPAC1 × 1 （O15160） DNA-directed RNA polymerase III subunit RPC9 × 1 （O75575） DNA-directed RNA polymerases I, II, and III subunit RPABC1 × 1 （P19388） DNA-directed RNA polymerases I, II, and III subunit RPABC2 × 1 （P61218） DNA-directed RNA polymerase III subunit RPC8 × 1 （Q9Y535） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （P52434） DNA-directed RNA polymerase III subunit RPC10 × 1 （Q9Y2Y1） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （P62875） DNA-directed RNA polymerases I and III subunit RPAC2 × 1 （P0DPB6） DNA-directed RNA polymerases I, II, and III subunit RPABC4 × 1 （P53803） DNA-directed RNA polymerase III subunit RPC5 × 1 （Q9NVU0） DNA-directed RNA polymerase III subunit RPC4 × 1 （P05423） DNA-directed RNA polymerase III subunit RPC3 × 1 （Q9BUI4） DNA-directed RNA polymerase III subunit RPC6 × 1 （Q9H1D9） DNA-directed RNA polymerase III subunit RPC7 × 1 （O15318） ZINC ION × 7 MAGNESIUM ION × 1 IRON/SULFUR CLUSTER × 1	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RPC1_HUMAN
Isoform	—
PDB entities	1
Chains and sequence ranges	Author chain A； PDBConstruct 1–1390； UniProt 1–1390

DNA-directed RNA polymerase III subunit RPC2

OrganismNot specified

UniProt Q9NW08

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 17	DNA-directed RNA polymerase III subunit RPC1 × 1 （O14802） DNA-directed RNA polymerases I and III subunit RPAC1 × 1 （O15160） DNA-directed RNA polymerase III subunit RPC9 × 1 （O75575） DNA-directed RNA polymerases I, II, and III subunit RPABC1 × 1 （P19388） DNA-directed RNA polymerases I, II, and III subunit RPABC2 × 1 （P61218） DNA-directed RNA polymerase III subunit RPC8 × 1 （Q9Y535） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （P52434） DNA-directed RNA polymerase III subunit RPC10 × 1 （Q9Y2Y1） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （P62875） DNA-directed RNA polymerases I and III subunit RPAC2 × 1 （P0DPB6） DNA-directed RNA polymerases I, II, and III subunit RPABC4 × 1 （P53803） DNA-directed RNA polymerase III subunit RPC5 × 1 （Q9NVU0） DNA-directed RNA polymerase III subunit RPC4 × 1 （P05423） DNA-directed RNA polymerase III subunit RPC3 × 1 （Q9BUI4） DNA-directed RNA polymerase III subunit RPC6 × 1 （Q9H1D9） DNA-directed RNA polymerase III subunit RPC7 × 1 （O15318） ZINC ION × 7 MAGNESIUM ION × 1 IRON/SULFUR CLUSTER × 1	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RPC2_HUMAN
Isoform	—
PDB entities	2
Chains and sequence ranges	Author chain B； PDBConstruct 1–1133； UniProt 1–1133

DNA-directed RNA polymerases I and III subunit RPAC1

OrganismNot specified

UniProt O15160

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 17	DNA-directed RNA polymerase III subunit RPC1 × 1 （O14802） DNA-directed RNA polymerase III subunit RPC2 × 1 （Q9NW08） DNA-directed RNA polymerase III subunit RPC9 × 1 （O75575） DNA-directed RNA polymerases I, II, and III subunit RPABC1 × 1 （P19388） DNA-directed RNA polymerases I, II, and III subunit RPABC2 × 1 （P61218） DNA-directed RNA polymerase III subunit RPC8 × 1 （Q9Y535） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （P52434） DNA-directed RNA polymerase III subunit RPC10 × 1 （Q9Y2Y1） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （P62875） DNA-directed RNA polymerases I and III subunit RPAC2 × 1 （P0DPB6） DNA-directed RNA polymerases I, II, and III subunit RPABC4 × 1 （P53803） DNA-directed RNA polymerase III subunit RPC5 × 1 （Q9NVU0） DNA-directed RNA polymerase III subunit RPC4 × 1 （P05423） DNA-directed RNA polymerase III subunit RPC3 × 1 （Q9BUI4） DNA-directed RNA polymerase III subunit RPC6 × 1 （Q9H1D9） DNA-directed RNA polymerase III subunit RPC7 × 1 （O15318） ZINC ION × 7 MAGNESIUM ION × 1 IRON/SULFUR CLUSTER × 1	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RPAC1_HUMAN
Isoform	—
PDB entities	3
Chains and sequence ranges	Author chain C； PDBConstruct 1–346； UniProt 1–346

DNA-directed RNA polymerase III subunit RPC9

OrganismNot specified

UniProt O75575

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 17	DNA-directed RNA polymerase III subunit RPC1 × 1 （O14802） DNA-directed RNA polymerase III subunit RPC2 × 1 （Q9NW08） DNA-directed RNA polymerases I and III subunit RPAC1 × 1 （O15160） DNA-directed RNA polymerases I, II, and III subunit RPABC1 × 1 （P19388） DNA-directed RNA polymerases I, II, and III subunit RPABC2 × 1 （P61218） DNA-directed RNA polymerase III subunit RPC8 × 1 （Q9Y535） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （P52434） DNA-directed RNA polymerase III subunit RPC10 × 1 （Q9Y2Y1） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （P62875） DNA-directed RNA polymerases I and III subunit RPAC2 × 1 （P0DPB6） DNA-directed RNA polymerases I, II, and III subunit RPABC4 × 1 （P53803） DNA-directed RNA polymerase III subunit RPC5 × 1 （Q9NVU0） DNA-directed RNA polymerase III subunit RPC4 × 1 （P05423） DNA-directed RNA polymerase III subunit RPC3 × 1 （Q9BUI4） DNA-directed RNA polymerase III subunit RPC6 × 1 （Q9H1D9） DNA-directed RNA polymerase III subunit RPC7 × 1 （O15318） ZINC ION × 7 MAGNESIUM ION × 1 IRON/SULFUR CLUSTER × 1	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RPC9_HUMAN
Isoform	—
PDB entities	4
Chains and sequence ranges	Author chain D； PDBConstruct 1–148； UniProt 1–148

DNA-directed RNA polymerases I, II, and III subunit RPABC1

OrganismNot specified

UniProt P19388

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 17	DNA-directed RNA polymerase III subunit RPC1 × 1 （O14802） DNA-directed RNA polymerase III subunit RPC2 × 1 （Q9NW08） DNA-directed RNA polymerases I and III subunit RPAC1 × 1 （O15160） DNA-directed RNA polymerase III subunit RPC9 × 1 （O75575） DNA-directed RNA polymerases I, II, and III subunit RPABC2 × 1 （P61218） DNA-directed RNA polymerase III subunit RPC8 × 1 （Q9Y535） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （P52434） DNA-directed RNA polymerase III subunit RPC10 × 1 （Q9Y2Y1） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （P62875） DNA-directed RNA polymerases I and III subunit RPAC2 × 1 （P0DPB6） DNA-directed RNA polymerases I, II, and III subunit RPABC4 × 1 （P53803） DNA-directed RNA polymerase III subunit RPC5 × 1 （Q9NVU0） DNA-directed RNA polymerase III subunit RPC4 × 1 （P05423） DNA-directed RNA polymerase III subunit RPC3 × 1 （Q9BUI4） DNA-directed RNA polymerase III subunit RPC6 × 1 （Q9H1D9） DNA-directed RNA polymerase III subunit RPC7 × 1 （O15318） ZINC ION × 7 MAGNESIUM ION × 1 IRON/SULFUR CLUSTER × 1	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RPAB1_HUMAN
Isoform	—
PDB entities	5
Chains and sequence ranges	Author chain E； PDBConstruct 1–210； UniProt 1–210

DNA-directed RNA polymerases I, II, and III subunit RPABC2

OrganismNot specified

UniProt P61218

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 17	DNA-directed RNA polymerase III subunit RPC1 × 1 （O14802） DNA-directed RNA polymerase III subunit RPC2 × 1 （Q9NW08） DNA-directed RNA polymerases I and III subunit RPAC1 × 1 （O15160） DNA-directed RNA polymerase III subunit RPC9 × 1 （O75575） DNA-directed RNA polymerases I, II, and III subunit RPABC1 × 1 （P19388） DNA-directed RNA polymerase III subunit RPC8 × 1 （Q9Y535） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （P52434） DNA-directed RNA polymerase III subunit RPC10 × 1 （Q9Y2Y1） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （P62875） DNA-directed RNA polymerases I and III subunit RPAC2 × 1 （P0DPB6） DNA-directed RNA polymerases I, II, and III subunit RPABC4 × 1 （P53803） DNA-directed RNA polymerase III subunit RPC5 × 1 （Q9NVU0） DNA-directed RNA polymerase III subunit RPC4 × 1 （P05423） DNA-directed RNA polymerase III subunit RPC3 × 1 （Q9BUI4） DNA-directed RNA polymerase III subunit RPC6 × 1 （Q9H1D9） DNA-directed RNA polymerase III subunit RPC7 × 1 （O15318） ZINC ION × 7 MAGNESIUM ION × 1 IRON/SULFUR CLUSTER × 1	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RPAB2_HUMAN
Isoform	—
PDB entities	6
Chains and sequence ranges	Author chain F； PDBConstruct 1–127； UniProt 1–127

DNA-directed RNA polymerase III subunit RPC8

OrganismNot specified

UniProt Q9Y535

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 17	DNA-directed RNA polymerase III subunit RPC1 × 1 （O14802） DNA-directed RNA polymerase III subunit RPC2 × 1 （Q9NW08） DNA-directed RNA polymerases I and III subunit RPAC1 × 1 （O15160） DNA-directed RNA polymerase III subunit RPC9 × 1 （O75575） DNA-directed RNA polymerases I, II, and III subunit RPABC1 × 1 （P19388） DNA-directed RNA polymerases I, II, and III subunit RPABC2 × 1 （P61218） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （P52434） DNA-directed RNA polymerase III subunit RPC10 × 1 （Q9Y2Y1） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （P62875） DNA-directed RNA polymerases I and III subunit RPAC2 × 1 （P0DPB6） DNA-directed RNA polymerases I, II, and III subunit RPABC4 × 1 （P53803） DNA-directed RNA polymerase III subunit RPC5 × 1 （Q9NVU0） DNA-directed RNA polymerase III subunit RPC4 × 1 （P05423） DNA-directed RNA polymerase III subunit RPC3 × 1 （Q9BUI4） DNA-directed RNA polymerase III subunit RPC6 × 1 （Q9H1D9） DNA-directed RNA polymerase III subunit RPC7 × 1 （O15318） ZINC ION × 7 MAGNESIUM ION × 1 IRON/SULFUR CLUSTER × 1	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RPC8_HUMAN
Isoform	—
PDB entities	7
Chains and sequence ranges	Author chain G； PDBConstruct 1–204； UniProt 1–204

DNA-directed RNA polymerases I, II, and III subunit RPABC3

OrganismNot specified

UniProt P52434

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 17	DNA-directed RNA polymerase III subunit RPC1 × 1 （O14802） DNA-directed RNA polymerase III subunit RPC2 × 1 （Q9NW08） DNA-directed RNA polymerases I and III subunit RPAC1 × 1 （O15160） DNA-directed RNA polymerase III subunit RPC9 × 1 （O75575） DNA-directed RNA polymerases I, II, and III subunit RPABC1 × 1 （P19388） DNA-directed RNA polymerases I, II, and III subunit RPABC2 × 1 （P61218） DNA-directed RNA polymerase III subunit RPC8 × 1 （Q9Y535） DNA-directed RNA polymerase III subunit RPC10 × 1 （Q9Y2Y1） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （P62875） DNA-directed RNA polymerases I and III subunit RPAC2 × 1 （P0DPB6） DNA-directed RNA polymerases I, II, and III subunit RPABC4 × 1 （P53803） DNA-directed RNA polymerase III subunit RPC5 × 1 （Q9NVU0） DNA-directed RNA polymerase III subunit RPC4 × 1 （P05423） DNA-directed RNA polymerase III subunit RPC3 × 1 （Q9BUI4） DNA-directed RNA polymerase III subunit RPC6 × 1 （Q9H1D9） DNA-directed RNA polymerase III subunit RPC7 × 1 （O15318） ZINC ION × 7 MAGNESIUM ION × 1 IRON/SULFUR CLUSTER × 1	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RPAB3_HUMAN
Isoform	—
PDB entities	8
Chains and sequence ranges	Author chain H； PDBConstruct 1–150； UniProt 1–150

DNA-directed RNA polymerase III subunit RPC10

OrganismNot specified

UniProt Q9Y2Y1

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 17	DNA-directed RNA polymerase III subunit RPC1 × 1 （O14802） DNA-directed RNA polymerase III subunit RPC2 × 1 （Q9NW08） DNA-directed RNA polymerases I and III subunit RPAC1 × 1 （O15160） DNA-directed RNA polymerase III subunit RPC9 × 1 （O75575） DNA-directed RNA polymerases I, II, and III subunit RPABC1 × 1 （P19388） DNA-directed RNA polymerases I, II, and III subunit RPABC2 × 1 （P61218） DNA-directed RNA polymerase III subunit RPC8 × 1 （Q9Y535） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （P52434） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （P62875） DNA-directed RNA polymerases I and III subunit RPAC2 × 1 （P0DPB6） DNA-directed RNA polymerases I, II, and III subunit RPABC4 × 1 （P53803） DNA-directed RNA polymerase III subunit RPC5 × 1 （Q9NVU0） DNA-directed RNA polymerase III subunit RPC4 × 1 （P05423） DNA-directed RNA polymerase III subunit RPC3 × 1 （Q9BUI4） DNA-directed RNA polymerase III subunit RPC6 × 1 （Q9H1D9） DNA-directed RNA polymerase III subunit RPC7 × 1 （O15318） ZINC ION × 7 MAGNESIUM ION × 1 IRON/SULFUR CLUSTER × 1	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RPC10_HUMAN
Isoform	—
PDB entities	9
Chains and sequence ranges	Author chain I； PDBConstruct 1–108； UniProt 1–108

DNA-directed RNA polymerases I, II, and III subunit RPABC5

OrganismNot specified

UniProt P62875

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 17	DNA-directed RNA polymerase III subunit RPC1 × 1 （O14802） DNA-directed RNA polymerase III subunit RPC2 × 1 （Q9NW08） DNA-directed RNA polymerases I and III subunit RPAC1 × 1 （O15160） DNA-directed RNA polymerase III subunit RPC9 × 1 （O75575） DNA-directed RNA polymerases I, II, and III subunit RPABC1 × 1 （P19388） DNA-directed RNA polymerases I, II, and III subunit RPABC2 × 1 （P61218） DNA-directed RNA polymerase III subunit RPC8 × 1 （Q9Y535） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （P52434） DNA-directed RNA polymerase III subunit RPC10 × 1 （Q9Y2Y1） DNA-directed RNA polymerases I and III subunit RPAC2 × 1 （P0DPB6） DNA-directed RNA polymerases I, II, and III subunit RPABC4 × 1 （P53803） DNA-directed RNA polymerase III subunit RPC5 × 1 （Q9NVU0） DNA-directed RNA polymerase III subunit RPC4 × 1 （P05423） DNA-directed RNA polymerase III subunit RPC3 × 1 （Q9BUI4） DNA-directed RNA polymerase III subunit RPC6 × 1 （Q9H1D9） DNA-directed RNA polymerase III subunit RPC7 × 1 （O15318） ZINC ION × 7 MAGNESIUM ION × 1 IRON/SULFUR CLUSTER × 1	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RPAB5_HUMAN
Isoform	—
PDB entities	10
Chains and sequence ranges	Author chain J； PDBConstruct 1–67； UniProt 1–67

DNA-directed RNA polymerases I and III subunit RPAC2

OrganismNot specified

UniProt P0DPB6

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 17	DNA-directed RNA polymerase III subunit RPC1 × 1 （O14802） DNA-directed RNA polymerase III subunit RPC2 × 1 （Q9NW08） DNA-directed RNA polymerases I and III subunit RPAC1 × 1 （O15160） DNA-directed RNA polymerase III subunit RPC9 × 1 （O75575） DNA-directed RNA polymerases I, II, and III subunit RPABC1 × 1 （P19388） DNA-directed RNA polymerases I, II, and III subunit RPABC2 × 1 （P61218） DNA-directed RNA polymerase III subunit RPC8 × 1 （Q9Y535） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （P52434） DNA-directed RNA polymerase III subunit RPC10 × 1 （Q9Y2Y1） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （P62875） DNA-directed RNA polymerases I, II, and III subunit RPABC4 × 1 （P53803） DNA-directed RNA polymerase III subunit RPC5 × 1 （Q9NVU0） DNA-directed RNA polymerase III subunit RPC4 × 1 （P05423） DNA-directed RNA polymerase III subunit RPC3 × 1 （Q9BUI4） DNA-directed RNA polymerase III subunit RPC6 × 1 （Q9H1D9） DNA-directed RNA polymerase III subunit RPC7 × 1 （O15318） ZINC ION × 7 MAGNESIUM ION × 1 IRON/SULFUR CLUSTER × 1	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RPAC2_HUMAN
Isoform	—
PDB entities	11
Chains and sequence ranges	Author chain K； PDBConstruct 1–133； UniProt 1–133

DNA-directed RNA polymerases I, II, and III subunit RPABC4

OrganismNot specified

UniProt P53803

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 17	DNA-directed RNA polymerase III subunit RPC1 × 1 （O14802） DNA-directed RNA polymerase III subunit RPC2 × 1 （Q9NW08） DNA-directed RNA polymerases I and III subunit RPAC1 × 1 （O15160） DNA-directed RNA polymerase III subunit RPC9 × 1 （O75575） DNA-directed RNA polymerases I, II, and III subunit RPABC1 × 1 （P19388） DNA-directed RNA polymerases I, II, and III subunit RPABC2 × 1 （P61218） DNA-directed RNA polymerase III subunit RPC8 × 1 （Q9Y535） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （P52434） DNA-directed RNA polymerase III subunit RPC10 × 1 （Q9Y2Y1） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （P62875） DNA-directed RNA polymerases I and III subunit RPAC2 × 1 （P0DPB6） DNA-directed RNA polymerase III subunit RPC5 × 1 （Q9NVU0） DNA-directed RNA polymerase III subunit RPC4 × 1 （P05423） DNA-directed RNA polymerase III subunit RPC3 × 1 （Q9BUI4） DNA-directed RNA polymerase III subunit RPC6 × 1 （Q9H1D9） DNA-directed RNA polymerase III subunit RPC7 × 1 （O15318） ZINC ION × 7 MAGNESIUM ION × 1 IRON/SULFUR CLUSTER × 1	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RPAB4_HUMAN
Isoform	—
PDB entities	12
Chains and sequence ranges	Author chain L； PDBConstruct 1–58； UniProt 1–58

DNA-directed RNA polymerase III subunit RPC5

OrganismNot specified

UniProt Q9NVU0

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 17	DNA-directed RNA polymerase III subunit RPC1 × 1 （O14802） DNA-directed RNA polymerase III subunit RPC2 × 1 （Q9NW08） DNA-directed RNA polymerases I and III subunit RPAC1 × 1 （O15160） DNA-directed RNA polymerase III subunit RPC9 × 1 （O75575） DNA-directed RNA polymerases I, II, and III subunit RPABC1 × 1 （P19388） DNA-directed RNA polymerases I, II, and III subunit RPABC2 × 1 （P61218） DNA-directed RNA polymerase III subunit RPC8 × 1 （Q9Y535） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （P52434） DNA-directed RNA polymerase III subunit RPC10 × 1 （Q9Y2Y1） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （P62875） DNA-directed RNA polymerases I and III subunit RPAC2 × 1 （P0DPB6） DNA-directed RNA polymerases I, II, and III subunit RPABC4 × 1 （P53803） DNA-directed RNA polymerase III subunit RPC4 × 1 （P05423） DNA-directed RNA polymerase III subunit RPC3 × 1 （Q9BUI4） DNA-directed RNA polymerase III subunit RPC6 × 1 （Q9H1D9） DNA-directed RNA polymerase III subunit RPC7 × 1 （O15318） ZINC ION × 7 MAGNESIUM ION × 1 IRON/SULFUR CLUSTER × 1	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RPC5_HUMAN
Isoform	—
PDB entities	13
Chains and sequence ranges	Author chain M； PDBConstruct 1–708； UniProt 1–708

DNA-directed RNA polymerase III subunit RPC4

OrganismNot specified

UniProt P05423

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 17	DNA-directed RNA polymerase III subunit RPC1 × 1 （O14802） DNA-directed RNA polymerase III subunit RPC2 × 1 （Q9NW08） DNA-directed RNA polymerases I and III subunit RPAC1 × 1 （O15160） DNA-directed RNA polymerase III subunit RPC9 × 1 （O75575） DNA-directed RNA polymerases I, II, and III subunit RPABC1 × 1 （P19388） DNA-directed RNA polymerases I, II, and III subunit RPABC2 × 1 （P61218） DNA-directed RNA polymerase III subunit RPC8 × 1 （Q9Y535） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （P52434） DNA-directed RNA polymerase III subunit RPC10 × 1 （Q9Y2Y1） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （P62875） DNA-directed RNA polymerases I and III subunit RPAC2 × 1 （P0DPB6） DNA-directed RNA polymerases I, II, and III subunit RPABC4 × 1 （P53803） DNA-directed RNA polymerase III subunit RPC5 × 1 （Q9NVU0） DNA-directed RNA polymerase III subunit RPC3 × 1 （Q9BUI4） DNA-directed RNA polymerase III subunit RPC6 × 1 （Q9H1D9） DNA-directed RNA polymerase III subunit RPC7 × 1 （O15318） ZINC ION × 7 MAGNESIUM ION × 1 IRON/SULFUR CLUSTER × 1	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RPC4_HUMAN
Isoform	—
PDB entities	14
Chains and sequence ranges	Author chain N； PDBConstruct 1–398； UniProt 1–398

DNA-directed RNA polymerase III subunit RPC3

OrganismNot specified

UniProt Q9BUI4

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 17	DNA-directed RNA polymerase III subunit RPC1 × 1 （O14802） DNA-directed RNA polymerase III subunit RPC2 × 1 （Q9NW08） DNA-directed RNA polymerases I and III subunit RPAC1 × 1 （O15160） DNA-directed RNA polymerase III subunit RPC9 × 1 （O75575） DNA-directed RNA polymerases I, II, and III subunit RPABC1 × 1 （P19388） DNA-directed RNA polymerases I, II, and III subunit RPABC2 × 1 （P61218） DNA-directed RNA polymerase III subunit RPC8 × 1 （Q9Y535） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （P52434） DNA-directed RNA polymerase III subunit RPC10 × 1 （Q9Y2Y1） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （P62875） DNA-directed RNA polymerases I and III subunit RPAC2 × 1 （P0DPB6） DNA-directed RNA polymerases I, II, and III subunit RPABC4 × 1 （P53803） DNA-directed RNA polymerase III subunit RPC5 × 1 （Q9NVU0） DNA-directed RNA polymerase III subunit RPC4 × 1 （P05423） DNA-directed RNA polymerase III subunit RPC6 × 1 （Q9H1D9） DNA-directed RNA polymerase III subunit RPC7 × 1 （O15318） ZINC ION × 7 MAGNESIUM ION × 1 IRON/SULFUR CLUSTER × 1	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RPC3_HUMAN
Isoform	—
PDB entities	15
Chains and sequence ranges	Author chain O； PDBConstruct 1–534； UniProt 1–534

DNA-directed RNA polymerase III subunit RPC6

OrganismNot specified

UniProt Q9H1D9

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 17	DNA-directed RNA polymerase III subunit RPC1 × 1 （O14802） DNA-directed RNA polymerase III subunit RPC2 × 1 （Q9NW08） DNA-directed RNA polymerases I and III subunit RPAC1 × 1 （O15160） DNA-directed RNA polymerase III subunit RPC9 × 1 （O75575） DNA-directed RNA polymerases I, II, and III subunit RPABC1 × 1 （P19388） DNA-directed RNA polymerases I, II, and III subunit RPABC2 × 1 （P61218） DNA-directed RNA polymerase III subunit RPC8 × 1 （Q9Y535） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （P52434） DNA-directed RNA polymerase III subunit RPC10 × 1 （Q9Y2Y1） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （P62875） DNA-directed RNA polymerases I and III subunit RPAC2 × 1 （P0DPB6） DNA-directed RNA polymerases I, II, and III subunit RPABC4 × 1 （P53803） DNA-directed RNA polymerase III subunit RPC5 × 1 （Q9NVU0） DNA-directed RNA polymerase III subunit RPC4 × 1 （P05423） DNA-directed RNA polymerase III subunit RPC3 × 1 （Q9BUI4） DNA-directed RNA polymerase III subunit RPC7 × 1 （O15318） ZINC ION × 7 MAGNESIUM ION × 1 IRON/SULFUR CLUSTER × 1	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RPC6_HUMAN
Isoform	—
PDB entities	16
Chains and sequence ranges	Author chain P； PDBConstruct 1–316； UniProt 1–316

DNA-directed RNA polymerase III subunit RPC7

OrganismNot specified

UniProt O15318

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 17	DNA-directed RNA polymerase III subunit RPC1 × 1 （O14802） DNA-directed RNA polymerase III subunit RPC2 × 1 （Q9NW08） DNA-directed RNA polymerases I and III subunit RPAC1 × 1 （O15160） DNA-directed RNA polymerase III subunit RPC9 × 1 （O75575） DNA-directed RNA polymerases I, II, and III subunit RPABC1 × 1 （P19388） DNA-directed RNA polymerases I, II, and III subunit RPABC2 × 1 （P61218） DNA-directed RNA polymerase III subunit RPC8 × 1 （Q9Y535） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （P52434） DNA-directed RNA polymerase III subunit RPC10 × 1 （Q9Y2Y1） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （P62875） DNA-directed RNA polymerases I and III subunit RPAC2 × 1 （P0DPB6） DNA-directed RNA polymerases I, II, and III subunit RPABC4 × 1 （P53803） DNA-directed RNA polymerase III subunit RPC5 × 1 （Q9NVU0） DNA-directed RNA polymerase III subunit RPC4 × 1 （P05423） DNA-directed RNA polymerase III subunit RPC3 × 1 （Q9BUI4） DNA-directed RNA polymerase III subunit RPC6 × 1 （Q9H1D9） ZINC ION × 7 MAGNESIUM ION × 1 IRON/SULFUR CLUSTER × 1	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RPC7_HUMAN
Isoform	—
PDB entities	17
Chains and sequence ranges	Author chain Q； PDBConstruct 1–223； UniProt 1–223

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id	7a6h
Deposition date deposition_date	2020-08-25
Structure title title	Cryo-EM structure of human apo RNA Polymerase III
Keywords keywords	Human RNA polymerase III, Synthesis of short RNAs, apo complex, TRANSCRIPTION; TRANSCRIPTION
Experimental Method method	ELECTRON MICROSCOPY

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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

7a6h__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

7a6h__assembly_1__model_1 | I(q)

100 plotted points; both axes use logarithmic scales.

7a6h__assembly_1__model_1 | P(r) · Pending

P(r) will be calculated and displayed separately for the same assembly/model.

Rg（Guinier）	58.76 Å
Rg (electron density)	58.19 Å
Total Rg	58.22 Å
Atom count	40216
Residues	5057
Excluded volume	719460 Å³
Maximum q	0.500 Å⁻¹

Assembly	Model	Structure unit	Oligomeric description	Status	CRYSOL	Actions
1	1	`7a6h__assembly_1__model_1`	heptadecameric （17）	Success	4.1.3-1-20251215 (887e7ef)	View Download

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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (20)

Entity 1 Entity 1 polymer

Description description	DNA-directed RNA polymerase III subunit RPC1
Molecular weight formula_weight	155860.1 kDa
EC 编号 ec_number	2.7.7.6
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	A
Atom count atom_count	40216

MVKEQFRETDVAKKISHICFGMKSPEEMRQQAHIQVVSKNLYSQDNQHAPLLYGVLDHRMGTSEKDRPCETCGKNLADCLGHYGYIDLELPCFHVGYFRAVIGILQMICKTCCHIMLSQEEKKQFLDYLKRPGLTYLQKRGLKKKISDKCRKKNICHHCGAFNGTVKKCGLLKIIHEKYKTNKKVVDPIVSNFLQSFETAIEHNKEVEPLLGRAQENLNPLVVLNLFKRIPAEDVPLLLMNPEAGKPSDLILTRLLVPPLCIRPSVVSDLKSGTNEDDLTMKLTEIIFLNDVIKKHRISGAKTQMIMEDWDFLQLQCALYINSELSGIPLNMAPKKWTRGFVQRLKGKQGRFRGNLSGKRVDFSGRTVISPDPNLRIDEVAVPVHVAKILTFPEKVNKANINFLRKLVQNGPEVHPGANFIQQRHTQMKRFLKYGNREKMAQELKYGDIVERHLIDGDVVLFNRQPSLHKLSIMAHLARVKPHRTFRFNECVCTPYNADFDGDEMNLHLPQTEEAKAEALVLMGTKANLVTPRNGEPLIAAIQDFLTGAYLLTLKDTFFDRAKACQIIASILVGKDEKIKVRLPPPTILKPVTLWTGKQIFSVILRPSDDNPVRANLRTKGKQYCGKGEDLCANDSYVTIQNSELMSGSMDKGTLGSGSKNNIFYILLRDWGQNEAADAMSRLARLAPVYLSNRGFSIGIGDVTPGQGLLKAKYELLNAGYKKCDEYIEALNTGKLQQQPGCTAEETLEALILKELSVIRDHAGSACLRELDKSNSPLTMALCGSKGSFINISQMIACVGQQAISGSRVPDGFENRSLPHFEKHSKLPAAKGFVANSFYSGLTPTEFFFHTMAGREGLVDTAVKTAETGYMQRRLVKSLEDLCSQYDLTVRSSTGDIIQFIYGGDGLDPAAMEGKDEPLEFKRVLDNIKAVFPCPSEPALSKNELILTTESIMKKSEFLCCQDSFLQEIKKFIKGVSEKIKKTRDKYGINDNGTTEPRVLYQLDRITPTQVEKFLETCRDKYMRAQMEPGSAVGALCAQSIGEPGTQMTLKTFHFAGVASMNITLGVPRIKEIINASKAISTPIITAQLDKDDDADYARLVKGRIEKTLLGEISEYIEEVFLPDDCFILVKLSLERIRLLRLEVNAETVRYSICTSKLRVKPGDVAVHGEAVVCVTPRENSKSSMYYVLQFLKEDLPKVVVQGIPEVSRAVIHIDEQSGKEKYKLLVEGDNLRAVMATHGVKGTRTTSNNTYEVEKTLGIEAARTTIINEIQYTMVNHGMSIDRRHVMLLSDLMTYKGEVLGITRFGLAKMKESVLMLASFEKTADHLFDAAYFGQKDSVCGVSECIIMGIPMNIGTGLFKLLHKADRDPNPPKRPLIFDTNEFHIPLVT

Entity 2 Entity 2 polymer

Description description	DNA-directed RNA polymerase III subunit RPC2
Molecular weight formula_weight	127953.9 kDa
EC 编号 ec_number	2.7.7.6
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	B

MDVLAEEFGNLTPEQLAAPIPTVEEKWRLLPAFLKVKGLVKQHIDSFNYFINVEIKKIMKANEKVTSDADPMWYLKYLNIYVGLPDVEESFNVTRPVSPHECRLRDMTYSAPITVDIEYTRGSQRIIRNALPIGRMPIMLRSSNCVLTGKTPAEFAKLNECPLDPGGYFIVKGVEKVILIQEQLSKNRIIVEADRKGAVGASVTSSTHEKKSRTNMAVKQGRFYLRHNTLSEDIPIVIIFKAMGVESDQEIVQMIGTEEHVMAAFGPSLEECQKAQIFTQMQALKYIGNKVRRQRMWGGGPKKTKIEEARELLASTILTHVPVKEFNFRAKCIYTAVMVRRVILAQGDNKVDDRDYYGNKRLELAGQLLSLLFEDLFKKFNSEMKKIADQVIPKQRAAQFDVVKHMRQDQITNGMVNAISTGNWSLKRFKMDRQGVTQVLSRLSYISALGMMTRISSQFEKTRKVSGPRSLQPSQWGMLCPSDTPEGEACGLVKNLALMTHITTDMEDGPIVKLASNLGVEDVNLLCGEELSYPNVFLVFLNGNILGVIRDHKKLVNTFRLMRRAGYINEFVSISTNLTDRCVYISSDGGRLCRPYIIVKKQKPAVTNKHMEELAQGYRNFEDFLHESLVEYLDVNEENDCNIALYEHTINKDTTHLEIEPFTLLGVCAGLIPYPHHNQSPRNTYQCAMGKQAMGTIGYNQRNRIDTLMYLLAYPQKPMVKTKTIELIEFEKLPAGQNATVAVMSYSGYDIEDALVLNKASLDRGFGRCLVYKNAKCTLKRYTNQTFDKVMGPMLDAATRKPIWRHEILDADGICSPGEKVENKQVLVNKSMPTVTQIPLEGSNVPQQPQYKDVPITYKGATDSYIEKVMISSNAEDAFLIKMLLRQTRRPEIGDKFSSRHGQKGVCGLIVPQEDMPFCDSGICPDIIMNPHGFPSRMTVGKLIELLAGKAGVLDGRFHYGTAFGGSKVKDVCEDLVRHGYNYLGKDYVTSGITGEPLEAYIYFGPVYYQKLKHMVLDKMHARARGPRAVLTRQPTEGRSRDGGLRLGEMERDCLIGYGASMLLLERLMISSDAFEVDVCGQCGLLGYSGWCHYCKSSCHVSSLRIPYACKLLFQELQSMNIIPRLKLSKYNE

Entity 3 Entity 3 polymer

Description description	DNA-directed RNA polymerases I and III subunit RPAC1
Molecular weight formula_weight	39301.7 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	C

MAASQAVEEMRSRVVLGEFGVRNVHTTDFPGNYSGYDDAWDQDRFEKNFRVDVVHMDENSLEFDMVGIDAAIANAFRRILLAEVPTMAVEKVLVYNNTSIVQDEILAHRLGLIPIHADPRLFEYRNQGDEEGTEIDTLQFRLQVRCTRNPHAAKDSSDPNELYVNHKVYTRHMTWIPLGNQADLFPEGTIRPVHDDILIAQLRPGQEIDLLMHCVKGIGKDHAKFSPVATASYRLLPDITLLEPVEGEAAEELSRCFSPGVIEVQEVQGKKVARVANPRLDTFSREIFRNEKLKKVVRLARVRDHYIFSVESTGVLPPDVLVSEAIKVLMGKCRRFLDELDAVQMD

Entity 4 Entity 4 polymer

Description description	DNA-directed RNA polymerase III subunit RPC9
Molecular weight formula_weight	16894.0 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	D

MEVKDANSALLSNYEVFQLLTDLKEQRKESGKNKHSSGQQNLNTITYETLKYISKTPCRHQSPEIVREFLTALKSHKLTKAEKLQLLNHRPVTAVEIQLMVEESEERLTEEQIEALLHTVTSILPAEPEAEQKKNTNSNVAMDEEDPA

Entity 5 Entity 5 polymer

Description description	DNA-directed RNA polymerases I, II, and III subunit RPABC1
Molecular weight formula_weight	24584.2 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	E

MDDEEETYRLWKIRKTIMQLCHDRGYLVTQDELDQTLEEFKAQSGDKPSEGRPRRTDLTVLVAHNDDPTDQMFVFFPEEPKVGIKTIKVYCQRMQEENITRALIVVQQGMTPSAKQSLVDMAPKYILEQFLQQELLINITEHELVPEHVVMTKEEVTELLARYKLRENQLPRIQAGDPVARYFGIKRGQVVKIIRPSETAGRYITYRLVQ

Entity 6 Entity 6 polymer

Description description	DNA-directed RNA polymerases I, II, and III subunit RPABC2
Molecular weight formula_weight	14491.0 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	F

MSDNEDNFDGDDFDDVEEDEGLDDLENAEEEGQENVEILPSGERPQANQKRITTPYMTKYERARVLGTRALQIAMCAPVMVELEGETDPLLIAMKELKARKIPIIIRRYLPDGSYEDWGVDELIITD

Entity 7 Entity 7 polymer

Description description	DNA-directed RNA polymerase III subunit RPC8
Molecular weight formula_weight	22938.8 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	G

MFVLVEMVDTVRIPPWQFERKLNDSIAEELNKKLANKVVYNVGLCICLFDITKLEDAYVFPGDGASHTKVHFRCVVFHPFLDEILIGKIKGCSPEGVHVSLGFFDDILIPPESLQQPAKFDEAEQVWVWEYETEEGAHDLYMDTGEEIRFRVVDESFVDTSPTGPSSADATTSSEELPKKEAPYTLVGSISEPGLGLLSWWTSN

Entity 8 Entity 8 polymer

Description description	DNA-directed RNA polymerases I, II, and III subunit RPABC3
Molecular weight formula_weight	17162.3 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	H

MAGILFEDIFDVKDIDPEGKKFDRVSRLHCESESFKMDLILDVNIQIYPVDLGDKFRLVIASTLYEDGTLDDGEYNPTDDRPSRADQFEYVMYGKVYRIEGDETSTEAATRLSAYVSYGGLLMRLQGDANNLHGFEVDSRVYLLMKKLAF

Entity 9 Entity 9 polymer

Description description	DNA-directed RNA polymerase III subunit RPC10
Molecular weight formula_weight	12354.1 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	I

MLLFCPGCGNGLIVEEGQRCHRFSCNTCPYVHNITRKVTNRKYPKLKEVDDVLGGAAAWENVDSTAESCPKCEHPRAYFMQLQTRSADEPMTTFYKCCNAQCGHRWRD

Entity 10 Entity 10 polymer

Description description	DNA-directed RNA polymerases I, II, and III subunit RPABC5
Molecular weight formula_weight	7655.1 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	J

MIIPVRCFTCGKIVGNKWEAYLGLLQAEYTEGDALDALGLKRYCCRRMLLAHVDLIEKLLNYAPLEK

Entity 11 Entity 11 polymer

Description description	DNA-directed RNA polymerases I and III subunit RPAC2
Molecular weight formula_weight	15259.2 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	K

MEEDQELERKISGLKTSMAEGERKTALEMVQAAGTDRHCVTFVLHEEDHTLGNSLRYMIMKNPEVEFCGYTTTHPSESKINLRIQTRGTLPAVEPFQRGLNELMNVCQHVLDKFEASIKDYKDQKASRNESTF

Entity 12 Entity 12 polymer

Description description	DNA-directed RNA polymerases I, II, and III subunit RPABC4
Molecular weight formula_weight	7018.2 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	L

MDTQKDVQPPKQQPMIYICGECHTENEIKSRDPIRCRECGYRIMYKKRTKRLVVFDAR

Entity 13 Entity 13 polymer

Description description	DNA-directed RNA polymerase III subunit RPC5
Molecular weight formula_weight	80004.0 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	M

MANEEDDPVVQEIDVYLAKSLAEKLYLFQYPVRPASMTYDDIPHLSAKIKPKQQKVELEMAIDTLNPNYCRSKGEQIALNVDGACADETSTYSSKLMDKQTFCSSQTTSNTSRYAAALYRQGELHLTPLHGILQLRPSFSYLDKADAKHREREAANEAGDSSQDEAEDDVKQITVRFSRPESEQARQRRVQSYEFLQKKHAEEPWVHLHYYGLRDSRSEHERQYLLCPGSSGVENTELVKSPSEYLMMLMPPSQEEEKDKPVAPSNVLSMAQLRTLPLADQIKILMKNVKVMPFANLMSLLGPSIDSVAVLRGIQKVAMLVQGNWVVKSDILYPKDSSSPHSGVPAEVLCRGRDFVMWKFTQSRWVVRKEVATVTKLCAEDVKDFLEHMAVVRINKGWEFILPYDGEFIKKHPDVVQRQHMLWTGIQAKLEKVYNLVKETMPKKPDAQSGPAGLVCGDQRIQVAKTKAQQNHALLERELQRRKEQLRVPAVPPGVRIKEEPVSEEGEEDEEQEAEEEPMDTSPSGLHSKLANGLPLGRAAGTDSFNGHPPQGCASTPVARELKAFVEATFQRQFVLTLSELKRLFNLHLASLPPGHTLFSGISDRMLQDTVLAAGCKQILVPFPPQTAASPDEQKVFALWESGDMSDQHRQVLLEIFSKNYRVRRNMIQSRLTQECGEDLSKQEVDKVLKDCCVSYGGMWYLKGTVQS

Entity 14 Entity 14 polymer

Description description	DNA-directed RNA polymerase III subunit RPC4
Molecular weight formula_weight	44471.9 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	N

MSEGNAAGEPSTPGGPRPLLTGARGLIGRRPAPPLTPGRLPSIRSRDLTLGGVKKKTFTPNIISRKIKEEPKEEVTVKKEKRERDRDRQREGHGRGRGRPEVIQSHSIFEQGPAEMMKKKGNWDKTVDVSDMGPSHIINIKKEKRETDEETKQILRMLEKDDFLDDPGLRNDTRNMPVQLPLAHSGWLFKEENDEPDVKPWLAGPKEEDMEVDIPAVKVKEEPRDEEEEAKMKAPPKAARKTPGLPKDVSVAELLRELSLTKEEELLFLQLPDTLPGQPPTQDIKPIKTEVQGEDGQVVLIKQEKDREAKLAENACTLADLTEGQVGKLLIRKSGRVQLLLGKVTLDVTMGTACSFLQELVSVGLGDSRTGEMTVLGHVKHKLVCSPDFESLLDHKHR

Entity 15 Entity 15 polymer

Description description	DNA-directed RNA polymerase III subunit RPC3
Molecular weight formula_weight	60692.6 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	O

MTQAEIKLCSLLLQEHFGEIVEKIGVHLIRTGSQPLRVIAHDTGTSLDQVKKALCVLVQHNLVSYQVHKRGVVEYEAQCSRVLRMLRYPRYIYTTKTLYSDTGELIVEELLLNGKLTMSAVVKKVADRLTETMEDGKTMDYAEVSNTFVRLADTHFVQRCPSVPTTENSDPGPPPPAPTLVINEKDMYLVPKLSLIGKGKRRRSSDEDAAGEPKAKRPKYTTDNKEPIPDDGIYWQANLDRFHQHFRDQAIVSAVANRMDQTSSEIVRTMLRMSEITTSSSAPFTQPLSSNEIFRSLPVGYNISKQVLDQYLTLLADDPLEFVGKSGDSGGGMYVINLHKALASLATATLESVVQERFGSRCARIFRLVLQKKHIEQKQVEDFAMIPAKEAKDMLYKMLSENFMSLQEIPKTPDHAPSRTFYLYTVNILSAARMLLHRCYKSIANLIERRQFETKENKRLLEKSQRVEAIIASMQATGAEEAQLQEIEEMITAPERQQLETLKRNVNKLDASEIQVDETIFLLESYIECTMKRQ

Entity 16 Entity 16 polymer

Description description	DNA-directed RNA polymerase III subunit RPC6
Molecular weight formula_weight	35726.9 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	P

MAEVKVKVQPPDADPVEIENRIIELCHQFPHGITDQVIQNEMPHIEAQQRAVAINRLLSMGQLDLLRSNTGLLYRIKDSQNAGKMKGSDNQEKLVYQIIEDAGNKGIWSRDIRYKSNLPLTEINKILKNLESKKLIKAVKSVAASKKKVYMLYNLQPDRSVTGGAWYSDQDFESEFVEVLNQQCFKFLQSKAETARESKQNPMIQRNSSFASSHEVWKYICELGISKVELSMEDIETILNTLIYDGKVEMTIIAAKEGTVGSVDGHMKLYRAVNPIIPPTGLVRAPCGLCPVFDDCHEGGEISPSNCIYMTEWLEF

Entity 17 Entity 17 polymer

Description description	DNA-directed RNA polymerase III subunit RPC7
Molecular weight formula_weight	25953.5 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	Q

MAGNKGRGRAAYTFNIEAVGFSKGEKLPDVVLKPPPLFPDTDYKPVPLKTGEGEEYMLALKQELRETMKRMPYFIETPEERQDIERYSKRYMKVYKEEWIPDWRRLPREMMPRNKCKKAGPKPKKAKDAGKGTPLTNTEDVLKKMEELEKRGDGEKSDEENEEKEGSKEKSKEGDDDDDDDAAEQEEYDEEEQEEENDYINSYFEDGDDFGADSDDNMDEATY

Entity 18 Entity 18 non-polymer

Description description	ZINC ION
Molecular weight formula_weight	65.4 kDa
Source method src_method	syn
Copy count entity_count	7

Entity 19 Entity 19 non-polymer

Description description	MAGNESIUM ION
Molecular weight formula_weight	24.3 kDa
Source method src_method	syn
Copy count entity_count	1

Entity 20 Entity 20 non-polymer

Description description	IRON/SULFUR CLUSTER
Molecular weight formula_weight	351.6 kDa
Source method src_method	syn
Copy count entity_count	1

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6. Fold Classification (SCOP + CATH) 6 domains

CATH v4.4 (6 domains)

Domain ID domain_id	7a6hA01
Class class	1 — Mainly Alpha
Architecture architecture	10 — Orthogonal Bundle
Topology topology	274 — Enzyme I; Chain A, domain 2
Homologous superfamily homologous superfamily	100 — RNA polymerase Rpb1, domain 3

Domain ID domain_id	7a6hC01
Class class	2 — Mainly Beta
Architecture architecture	170 — Beta Complex
Topology topology	120 — RNA Polymerase Alpha Subunit; Chain A, domain 2
Homologous superfamily homologous superfamily	12 — DNA-directed RNA polymerase, insert domain

Domain ID domain_id	7a6hI01
Class class	2 — Mainly Beta
Architecture architecture	20 — Single Sheet
Topology topology	25 — N-terminal domain of TfIIb
Homologous superfamily homologous superfamily	10 —

Domain ID domain_id	7a6hO01
Class class	1 — Mainly Alpha
Architecture architecture	10 — Orthogonal Bundle
Topology topology	10 — Arc Repressor Mutant, subunit A
Homologous superfamily homologous superfamily	10 — Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain

Domain ID domain_id	7a6hO02
Class class	1 — Mainly Alpha
Architecture architecture	10 — Orthogonal Bundle
Topology topology	10 — Arc Repressor Mutant, subunit A
Homologous superfamily homologous superfamily	10 — Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain

Domain ID domain_id	7a6hO03
Class class	1 — Mainly Alpha
Architecture architecture	10 — Orthogonal Bundle
Topology topology	10 — Arc Repressor Mutant, subunit A
Homologous superfamily homologous superfamily	10 — Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain

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Resolution resolution	3.30 Å
Resolution测定Method resolution_method	—
颗粒数 num_particles	111289

Cryo-EM structure of human apo RNA Polymerase III

1. Protein Identity and Related Structures Protein Identity & Related Structures

DNA-directed RNA polymerase III subunit RPC1

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

DNA-directed RNA polymerase III subunit RPC2

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

DNA-directed RNA polymerases I and III subunit RPAC1

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

DNA-directed RNA polymerase III subunit RPC9

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

DNA-directed RNA polymerases I, II, and III subunit RPABC1

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

DNA-directed RNA polymerases I, II, and III subunit RPABC2

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

DNA-directed RNA polymerase III subunit RPC8

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

DNA-directed RNA polymerases I, II, and III subunit RPABC3

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

DNA-directed RNA polymerase III subunit RPC10

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

DNA-directed RNA polymerases I, II, and III subunit RPABC5

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer