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7e2z

Aripiprazole-bound serotonin 1A (5-HT1A) receptor-Gi protein complex

Method: ELECTRON MICROSCOPY
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Guanine nucleotide-binding protein G(i) subunit alpha-1

Homo sapiens

UniProt P63096

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Insufficient information Heteromer Protein 4 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 × 1 （P62873） Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 × 1 （P59768） Soluble cytochrome b562,5-hydroxytryptamine receptor 1A × 1 （P08908,P0ABE7） 7-[4-[4-[2,3-bis(chloranyl)phenyl]piperazin-1-yl]butoxy]-3,4-dihydro-1H-quinolin-2-one × 1 CHOLESTEROL × 3 ;[(2R)-1-[oxidanyl-[(2R,3R,5S,6R)-2,3,5,6-tetrakis(oxidanyl)-4-phosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-3-tetradecanoyloxy-propan-2-yl] (5E,8E)-hexadeca-5,8,11,14-tetraenoate ; × 1 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
3qe0 3umr 3ums 5js7 5js8

5 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1kjy 1kjy 1kjy 1y3a 1y3a 1y3a 1y3a 20yc 20zc 20zd 20zg 20zh

587 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name GNAI1_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–354； UniProt 1–354

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

Homo sapiens

UniProt P62873

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Insufficient information Heteromer Protein 4 Guanine nucleotide-binding protein G(i) subunit alpha-1 × 1 （P63096） Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 × 1 （P59768） Soluble cytochrome b562,5-hydroxytryptamine receptor 1A × 1 （P08908,P0ABE7） 7-[4-[4-[2,3-bis(chloranyl)phenyl]piperazin-1-yl]butoxy]-3,4-dihydro-1H-quinolin-2-one × 1 CHOLESTEROL × 3 ;[(2R)-1-[oxidanyl-[(2R,3R,5S,6R)-2,3,5,6-tetrakis(oxidanyl)-4-phosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-3-tetradecanoyloxy-propan-2-yl] (5E,8E)-hexadeca-5,8,11,14-tetraenoate ; × 1 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
20yc 20zc 20zd 20zg 20zh 20zi 20zj 20zk 20zl 21ag 21du 23iv

1264 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name GBB1_HUMAN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain B； PDBConstruct 7–345； UniProt 2–340

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

Homo sapiens

UniProt P59768

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Insufficient information Heteromer Protein 4 Guanine nucleotide-binding protein G(i) subunit alpha-1 × 1 （P63096） Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 × 1 （P62873） Soluble cytochrome b562,5-hydroxytryptamine receptor 1A × 1 （P08908,P0ABE7） 7-[4-[4-[2,3-bis(chloranyl)phenyl]piperazin-1-yl]butoxy]-3,4-dihydro-1H-quinolin-2-one × 1 CHOLESTEROL × 3 ;[(2R)-1-[oxidanyl-[(2R,3R,5S,6R)-2,3,5,6-tetrakis(oxidanyl)-4-phosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-3-tetradecanoyloxy-propan-2-yl] (5E,8E)-hexadeca-5,8,11,14-tetraenoate ; × 1 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
20yc 20zc 20zd 20zg 20zh 20zi 20zj 20zk 20zl 21ag 21du 23iv

1237 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name GBG2_HUMAN
Isoform —
PDB entities 3
Chains and sequence ranges Author chain G； PDBConstruct 1–71； UniProt 1–71

Soluble cytochrome b562,5-hydroxytryptamine receptor 1A

Homo sapiens

UniProt P08908

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Insufficient information Heteromer Protein 4 Guanine nucleotide-binding protein G(i) subunit alpha-1 × 1 （P63096） Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 × 1 （P62873） Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 × 1 （P59768） 7-[4-[4-[2,3-bis(chloranyl)phenyl]piperazin-1-yl]butoxy]-3,4-dihydro-1H-quinolin-2-one × 1 CHOLESTEROL × 3 ;[(2R)-1-[oxidanyl-[(2R,3R,5S,6R)-2,3,5,6-tetrakis(oxidanyl)-4-phosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-3-tetradecanoyloxy-propan-2-yl] (5E,8E)-hexadeca-5,8,11,14-tetraenoate ; × 1 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
7e2x 7e2y 7e2z 8fy8 8fye 8fyl 8fyt 8fyx 8jsp 8jt6 8pjk 8pkm

31 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name 5HT1A_HUMAN
Isoform —
PDB entities 4
Chains and sequence ranges Author chain R； PDBConstruct 146–543； UniProt 25–422

Soluble cytochrome b562,5-hydroxytryptamine receptor 1A

Homo sapiens

UniProt P0ABE7

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Insufficient information Heteromer Protein 4 Guanine nucleotide-binding protein G(i) subunit alpha-1 × 1 （P63096） Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 × 1 （P62873） Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 × 1 （P59768） 7-[4-[4-[2,3-bis(chloranyl)phenyl]piperazin-1-yl]butoxy]-3,4-dihydro-1H-quinolin-2-one × 1 CHOLESTEROL × 3 ;[(2R)-1-[oxidanyl-[(2R,3R,5S,6R)-2,3,5,6-tetrakis(oxidanyl)-4-phosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-3-tetradecanoyloxy-propan-2-yl] (5E,8E)-hexadeca-5,8,11,14-tetraenoate ; × 1 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1apc 1m6t 1qpu 1qq3 256b 256b 2bc5 2bc5 2bc5 2bc5 3fop 3fop

78 assemblies; showing the first 12

Homodimer
1lm3 2bc5 2bc5 3de8 3de8 3hnk 3hnl 3l1m 3tol 3tol 3tom 3tom

35 assemblies; showing the first 12

Homotetramer
2bc5 2bc5 2bc5 2bc5 2qla 3c62 3c63 3de8 3hni 3hni 3hnj 3hnl

36 assemblies; showing the first 12

Other homooligomers
3de9 3foo 3foo 3foo 3foo 3fop 3m15 3m4b 6dhz 6ot4 6ot7 6ot8

39 assemblies; showing the first 12

Heteromeric or nucleic-acid complex
10kt 11td 11tf 11th 11tk 11tl 22em 24xy 24xz 25ik 25il 28vj

635 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name C562_ECOLX
Isoform —
PDB entities 4
Chains and sequence ranges Author chain R； PDBConstruct 29–134； UniProt 23–128

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id7e2z
Deposition date deposition_date2021-02-07
Structure title titleAripiprazole-bound serotonin 1A (5-HT1A) receptor-Gi protein complex
Keywords keywordsSerotonin, 5-HT1A, GPCR, Complex, G protein, Gi, aripiprazole, SIGNALING PROTEIN; SIGNALING PROTEIN
Experimental Method methodELECTRON MICROSCOPY
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

7e2z__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

7e2z__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

7e2z__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）33.87 Å
Rg (electron density)33.78 Å
Total Rg34.32 Å
Atom count6997
Residues870
Excluded volume126170 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 7e2z__assembly_1__model_1 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (7)

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6. Fold Classification (SCOP + CATH) 2 domains

SCOP 2.08 (1 domains)

Domain ID domain_idd7e2zb_
Class classb — All beta proteins
Fold Fold foldb.69 — 7-bladed beta-propeller
Superfamily Superfamily superfamilyb.69.4 — WD40 repeat-like
Family Family familyb.69.4.1 — WD40-repeat

CATH v4.4 (1 domains)

Domain ID domain_id7e2zB01
Class class2 — Mainly Beta
Architecture architecture130 — 7 Propeller
Topology topology10 — Methylamine Dehydrogenase; Chain H
Homologous superfamily homologous superfamily10 — YVTN repeat-like/Quinoprotein amine dehydrogenase
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7. Citations (1)