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7nsg

Structure of human excitatory amino acid transporter 3 (EAAT3) in complex with HIP-B

Method: ELECTRON MICROSCOPY
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Excitatory amino acid transporter 3

Homo sapiens

UniProt P43005

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein homooligomer Homooligomer Protein 3 (+)-3-Hydroxy-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d]isoxazole-6-carboxylic acid × 3 (-)-3-Hydroxy-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d]isoxazole-6-carboxylic acid × 3 CHOLESTEROL HEMISUCCINATE × 3 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 15 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
6x2z 8ctd 8cud 8cuj 8cv3 9d68 9d69 9d6a 9p4x 9p4y 9p4z

11 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers
6s3q 6x2l 6x3e 6x3f 7nsg 8ctc 8cua 8cui 8cv2 9d66 9d67

11 assemblies

Heteromeric or nucleic-acid complex

None

View Construct and Data Evidence
UniProt name EAA3_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–480； UniProt 1–480 Author chain B； PDBConstruct 1–480； UniProt 1–480 Author chain C； PDBConstruct 1–480； UniProt 1–480

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id7nsg
Deposition date deposition_date2021-03-05
Structure title titleStructure of human excitatory amino acid transporter 3 (EAAT3) in complex with HIP-B
Keywords keywords;GLUTAMATE, ASPARTATE TRANSPORTER, CYSTEINE, INHIBITOR COMPLEX, MEMBRANE PROTEIN, Structural Genomics, Structural Genomics Consortium, SGC ;; MEMBRANE PROTEIN
Experimental Method methodELECTRON MICROSCOPY
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

7nsg__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

7nsg__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

7nsg__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）36.20 Å
Rg (electron density)35.15 Å
Total Rg35.69 Å
Atom count10320
Residues1290
Excluded volume192130 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 7nsg__assembly_1__model_1 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (5)

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6. Fold Classification (SCOP + CATH) 3 domains

CATH v4.4 (3 domains)

Domain ID domain_id7nsgA01
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology3860 — Proton glutamate symport protein
Homologous superfamily homologous superfamily10 — Sodium:dicarboxylate symporter
Domain ID domain_id7nsgB01
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology3860 — Proton glutamate symport protein
Homologous superfamily homologous superfamily10 — Sodium:dicarboxylate symporter
Domain ID domain_id7nsgC01
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology3860 — Proton glutamate symport protein
Homologous superfamily homologous superfamily10 — Sodium:dicarboxylate symporter
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7. Citations (1)