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7sz5

Cryo-EM structure of the extracellular module of the full-length EGFR bound to TGF-alpha "tips-separated" conformation

Method: ELECTRON MICROSCOPY
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Epidermal growth factor receptor

Homo sapiens

UniProt P00533

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 4 Transforming growth factor alpha × 2 （P01135） Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1m14 1m17 1xkk 1z9i 2itn 2ito 2itp 2itq 2itt 2itu 2itv 2itw

358 assemblies; showing the first 12

Homodimer
2eb2 2eb3 2gs2 2gs7 2m0b 2m20 3gop 3gt8 3ika 3ug1 3ug2 3vjn

91 assemblies; showing the first 12

Homotetramer
5gty 5gty

2 assemblies

Other homooligomers

None

Heteromeric or nucleic-acid complex
1ivo 1mox 1yy9 2ks1 2rf9 2rf9 2rfd 2rfd 2rfe 2rfe 3b2u 3b2u

115 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name EGFR_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–1210； UniProt 1–1210 Author chain B； PDBConstruct 1–1210； UniProt 1–1210

Transforming growth factor alpha

Homo sapiens

UniProt P01135

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 4 Epidermal growth factor receptor × 2 （P00533） Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1yuf 1yug 2tgf 3tgf 4tgf

5 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1gk5 1mox 1p9j 3e50 3e50 5kn5 5kn5 7sz5 7sz7

9 assemblies

View Construct and Data Evidence
UniProt name TGFA_HUMAN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain C； PDBConstruct 1–50； UniProt 40–89 Author chain D； PDBConstruct 1–50； UniProt 40–89

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id7sz5
Deposition date deposition_date2021-11-25
Structure title titleCryo-EM structure of the extracellular module of the full-length EGFR bound to TGF-alpha "tips-separated" conformation
Keywords keywordsreceptor tyrosine kinases, epidermal growth factor receptor, SIGNALING PROTEIN; SIGNALING PROTEIN
Experimental Method methodELECTRON MICROSCOPY
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

7sz5__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

7sz5__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

7sz5__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）42.71 Å
Rg (electron density)42.37 Å
Total Rg42.48 Å
Atom count9367
Residues1214
Excluded volume165050 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 7sz5__assembly_1__model_1 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (2)

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7. Citations (1)