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7tx6

Cryo-EM structure of the human reduced folate carrier in complex with methotrexate

Method: ELECTRON MICROSCOPY
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Reduced folate transporter,Soluble cytochrome b562

Homo sapiens

UniProt P0ABE7

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Insufficient information Monomer Protein 1 METHOTREXATE × 1 Digitonin × 1 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1apc 1m6t 1qpu 1qq3 256b 256b 2bc5 2bc5 2bc5 2bc5 3fop 3fop

78 assemblies; showing the first 12

Homodimer
1lm3 2bc5 2bc5 3de8 3de8 3hnk 3hnl 3l1m 3tol 3tol 3tom 3tom

35 assemblies; showing the first 12

Homotetramer
2bc5 2bc5 2bc5 2bc5 2qla 3c62 3c63 3de8 3hni 3hni 3hnj 3hnl

36 assemblies; showing the first 12

Other homooligomers
3de9 3foo 3foo 3foo 3foo 3fop 3m15 3m4b 6dhz 6ot4 6ot7 6ot8

39 assemblies; showing the first 12

Heteromeric or nucleic-acid complex
10kt 11td 11tf 11th 11tk 11tl 22em 24xy 24xz 25ik 25il 28vj

635 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name C562_ECOLX
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 216–318； UniProt 25–127

Reduced folate transporter,Soluble cytochrome b562

Homo sapiens

UniProt P41440

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Insufficient information Monomer Protein 1 METHOTREXATE × 1 Digitonin × 1 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
7xpz 7xq0 7xq1 7xq2 7xtk 8goe 8gof

7 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
7tx6 7tx7 8dep 8hii 8hij 8hik 9joz 9jri 9jrk 9jrl 9jrm 9jrn

12 assemblies

View Construct and Data Evidence
UniProt name S19A1_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–215； UniProt 1–215 Author chain A； PDBConstruct 320–669； UniProt 242–591

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id7tx6
Deposition date deposition_date2022-02-07
Structure title titleCryo-EM structure of the human reduced folate carrier in complex with methotrexate
Keywords keywordstransporter, reduced folate carrier, SLC19A1, TRANSPORT PROTEIN, anion exchanger; TRANSPORT PROTEIN
Experimental Method methodELECTRON MICROSCOPY
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

7tx6__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

7tx6__assembly_1__model_1 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

7tx6__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）22.75 Å
Rg (electron density)21.66 Å
Total Rg22.84 Å
Atom count3169
Residues398
Excluded volume57852 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 7tx6__assembly_1__model_1 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (3)

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7. Citations (1)