7x3u

cryo-EM structure of human TRiC-ADP

Method: ELECTRON MICROSCOPY
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1. Protein Identity and Related Structures Protein Identity & Related Structures

T-complex protein 1 subunit alpha

Homo sapiens

UniProt P17987

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 16 T-complex protein 1 subunit beta × 2 (P78371) T-complex protein 1 subunit delta × 2 (P50991) T-complex protein 1 subunit epsilon × 2 (P48643) T-complex protein 1 subunit gamma × 2 (P49368) T-complex protein 1 subunit eta × 2 (Q99832) T-complex protein 1 subunit theta × 2 (P50990) T-complex protein 1 subunit zeta × 2 (P40227) ADENOSINE-5'-DIPHOSPHATE × 16 Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name TCPA_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A; PDBConstruct 1–556; UniProt 1–556 Author chain a; PDBConstruct 1–556; UniProt 1–556

T-complex protein 1 subunit beta

Homo sapiens

UniProt P78371

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 16 T-complex protein 1 subunit alpha × 2 (P17987) T-complex protein 1 subunit delta × 2 (P50991) T-complex protein 1 subunit epsilon × 2 (P48643) T-complex protein 1 subunit gamma × 2 (P49368) T-complex protein 1 subunit eta × 2 (Q99832) T-complex protein 1 subunit theta × 2 (P50990) T-complex protein 1 subunit zeta × 2 (P40227) ADENOSINE-5'-DIPHOSPHATE × 16 Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name TCPB_HUMAN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain B; PDBConstruct 1–535; UniProt 1–535 Author chain b; PDBConstruct 1–535; UniProt 1–535

T-complex protein 1 subunit delta

Homo sapiens

UniProt P50991

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 16 T-complex protein 1 subunit alpha × 2 (P17987) T-complex protein 1 subunit beta × 2 (P78371) T-complex protein 1 subunit epsilon × 2 (P48643) T-complex protein 1 subunit gamma × 2 (P49368) T-complex protein 1 subunit eta × 2 (Q99832) T-complex protein 1 subunit theta × 2 (P50990) T-complex protein 1 subunit zeta × 2 (P40227) ADENOSINE-5'-DIPHOSPHATE × 16 Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name TCPD_HUMAN
Isoform —
PDB entities 3
Chains and sequence ranges Author chain D; PDBConstruct 1–539; UniProt 1–539 Author chain d; PDBConstruct 1–539; UniProt 1–539

T-complex protein 1 subunit epsilon

Homo sapiens

UniProt P48643

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 16 T-complex protein 1 subunit alpha × 2 (P17987) T-complex protein 1 subunit beta × 2 (P78371) T-complex protein 1 subunit delta × 2 (P50991) T-complex protein 1 subunit gamma × 2 (P49368) T-complex protein 1 subunit eta × 2 (Q99832) T-complex protein 1 subunit theta × 2 (P50990) T-complex protein 1 subunit zeta × 2 (P40227) ADENOSINE-5'-DIPHOSPHATE × 16 Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name TCPE_HUMAN
Isoform —
PDB entities 4
Chains and sequence ranges Author chain E; PDBConstruct 1–539; UniProt 3–541 Author chain e; PDBConstruct 1–539; UniProt 3–541

T-complex protein 1 subunit gamma

Homo sapiens

UniProt P49368

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 16 T-complex protein 1 subunit alpha × 2 (P17987) T-complex protein 1 subunit beta × 2 (P78371) T-complex protein 1 subunit delta × 2 (P50991) T-complex protein 1 subunit epsilon × 2 (P48643) T-complex protein 1 subunit eta × 2 (Q99832) T-complex protein 1 subunit theta × 2 (P50990) T-complex protein 1 subunit zeta × 2 (P40227) ADENOSINE-5'-DIPHOSPHATE × 16 Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name TCPG_HUMAN
Isoform —
PDB entities 5
Chains and sequence ranges Author chain G; PDBConstruct 1–545; UniProt 1–545 Author chain g; PDBConstruct 1–545; UniProt 1–545

T-complex protein 1 subunit eta

Homo sapiens

UniProt Q99832

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 16 T-complex protein 1 subunit alpha × 2 (P17987) T-complex protein 1 subunit beta × 2 (P78371) T-complex protein 1 subunit delta × 2 (P50991) T-complex protein 1 subunit epsilon × 2 (P48643) T-complex protein 1 subunit gamma × 2 (P49368) T-complex protein 1 subunit theta × 2 (P50990) T-complex protein 1 subunit zeta × 2 (P40227) ADENOSINE-5'-DIPHOSPHATE × 16 Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name TCPH_HUMAN
Isoform —
PDB entities 6
Chains and sequence ranges Author chain H; PDBConstruct 1–543; UniProt 1–543 Author chain h; PDBConstruct 1–543; UniProt 1–543

T-complex protein 1 subunit theta

Homo sapiens

UniProt P50990

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 16 T-complex protein 1 subunit alpha × 2 (P17987) T-complex protein 1 subunit beta × 2 (P78371) T-complex protein 1 subunit delta × 2 (P50991) T-complex protein 1 subunit epsilon × 2 (P48643) T-complex protein 1 subunit gamma × 2 (P49368) T-complex protein 1 subunit eta × 2 (Q99832) T-complex protein 1 subunit zeta × 2 (P40227) ADENOSINE-5'-DIPHOSPHATE × 16 Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name TCPQ_HUMAN
Isoform —
PDB entities 7
Chains and sequence ranges Author chain Q; PDBConstruct 1–548; UniProt 1–548 Author chain q; PDBConstruct 1–548; UniProt 1–548

T-complex protein 1 subunit zeta

Homo sapiens

UniProt P40227

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 16 T-complex protein 1 subunit alpha × 2 (P17987) T-complex protein 1 subunit beta × 2 (P78371) T-complex protein 1 subunit delta × 2 (P50991) T-complex protein 1 subunit epsilon × 2 (P48643) T-complex protein 1 subunit gamma × 2 (P49368) T-complex protein 1 subunit eta × 2 (Q99832) T-complex protein 1 subunit theta × 2 (P50990) ADENOSINE-5'-DIPHOSPHATE × 16 Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name TCPZ_HUMAN
Isoform —
PDB entities 8
Chains and sequence ranges Author chain Z; PDBConstruct 1–531; UniProt 1–531 Author chain z; PDBConstruct 1–531; UniProt 1–531

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id7x3u
Deposition date deposition_date2022-03-01
Structure title titlecryo-EM structure of human TRiC-ADP
Keywords keywordsSTRUCTURAL PROTEIN; STRUCTURAL PROTEIN
Experimental Method methodELECTRON MICROSCOPY
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

7x3u__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

7x3u__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 109 1010 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

7x3u__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg(Guinier)72.02 Å
Rg (electron density)71.47 Å
Total Rg71.58 Å
Atom count62495
Residues8121
Excluded volume1120300 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 7x3u__assembly_1__model_1 hexadecameric (16) Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (9)

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6. Fold Classification (SCOP + CATH) 7 domains

CATH v4.4 (7 domains)

Domain ID domain_id7x3uB01
Class class3 — Alpha Beta
Architecture architecture50 — 3-Layer(bba) Sandwich
Topology topology7 — GroEL
Homologous superfamily homologous superfamily10 — GroEL
Domain ID domain_id7x3uH01
Class class3 — Alpha Beta
Architecture architecture50 — 3-Layer(bba) Sandwich
Topology topology7 — GroEL
Homologous superfamily homologous superfamily10 — GroEL
Domain ID domain_id7x3uQ01
Class class3 — Alpha Beta
Architecture architecture50 — 3-Layer(bba) Sandwich
Topology topology7 — GroEL
Homologous superfamily homologous superfamily10 — GroEL
Domain ID domain_id7x3ua01
Class class3 — Alpha Beta
Architecture architecture50 — 3-Layer(bba) Sandwich
Topology topology7 — GroEL
Homologous superfamily homologous superfamily10 — GroEL
Domain ID domain_id7x3ub01
Class class3 — Alpha Beta
Architecture architecture50 — 3-Layer(bba) Sandwich
Topology topology7 — GroEL
Homologous superfamily homologous superfamily10 — GroEL
Domain ID domain_id7x3uh01
Class class3 — Alpha Beta
Architecture architecture50 — 3-Layer(bba) Sandwich
Topology topology7 — GroEL
Homologous superfamily homologous superfamily10 — GroEL
Domain ID domain_id7x3uq01
Class class3 — Alpha Beta
Architecture architecture50 — 3-Layer(bba) Sandwich
Topology topology7 — GroEL
Homologous superfamily homologous superfamily10 — GroEL
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7. Citations (1)