8g6e

Structure of the Plasmodium falciparum 20S proteasome complexed with inhibitor TDI-8304

Method: ELECTRON MICROSCOPY D_max: 196.5 Å Quality: GOOD

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1. Protein Identity and Related Structures Protein Identity & Related Structures

Proteasome subunit alpha type-6

OrganismNot specified

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein heterocomplex Heteromer Protein × 28 PDB declaration: 28-meric（28） Consistent with protein copy count	Chain A； UniProt 1–260 Chain O； UniProt 1–260	Not recorded	Proteasome subunit alpha type-2 × 2 （A0A2I0BQ13） Proteasome subunit alpha type × 2 （W7KN95） Proteasome subunit alpha type × 2 （A0A2I0BS43） Proteasome subunit alpha type × 2 （A0A2I0BP34） Proteasome subunit alpha type-1 × 2 （W7K5W7） Proteasome subunit alpha type-3 × 2 （W7K040） Proteasome subunit beta type-6 × 2 （W7JUG8） Proteasome subunit beta × 2 （W7K1J4） Proteasome subunit beta × 2 （A0A2I0BXS0） Proteasome subunit beta × 2 （W7JKG5） Proteasome subunit beta × 2 （W7K6A8） Proteasome subunit beta × 2 （A0A2I0BU46） Proteasome subunit beta × 2 （W7K6I2） YRE (7S,10S,13S)-N-cyclopentyl-10-[2-(morpholin-4-yl)ethyl]-9,12-dioxo-13-(2-oxopyrrolidin-1-yl)-2-oxa-8,11-diazabicyclo[13.3.1]nonadeca-1(19),15,17-triene-7-carboxamide × 6	ELECTRON MICROSCOPY cryo-EM buffer：pH 7.5 cryo-EM vitrification conditions：Cryogen ETHANE	Resolution 2.18 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

No other PDB entry for the same UniProt protein was found.

View Construct and Data Evidence

UniProt name	W7JVP8_PLAFO
Isoform	—
PDB entities	1
Chains and sequence ranges	Author chain A； PDBConstruct 1–260； UniProt 1–260 Author chain O； PDBConstruct 1–260； UniProt 1–260

Proteasome subunit alpha type-2

OrganismNot specified

UniProt A0A2I0BQ13

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein heterocomplex Heteromer Protein × 28 PDB declaration: 28-meric（28） Consistent with protein copy count	Chain B； UniProt 1–235 Chain P； UniProt 1–235	Not recorded	Proteasome subunit alpha type-6 × 2 （W7JVP8） Proteasome subunit alpha type × 2 （W7KN95） Proteasome subunit alpha type × 2 （A0A2I0BS43） Proteasome subunit alpha type × 2 （A0A2I0BP34） Proteasome subunit alpha type-1 × 2 （W7K5W7） Proteasome subunit alpha type-3 × 2 （W7K040） Proteasome subunit beta type-6 × 2 （W7JUG8） Proteasome subunit beta × 2 （W7K1J4） Proteasome subunit beta × 2 （A0A2I0BXS0） Proteasome subunit beta × 2 （W7JKG5） Proteasome subunit beta × 2 （W7K6A8） Proteasome subunit beta × 2 （A0A2I0BU46） Proteasome subunit beta × 2 （W7K6I2） YRE (7S,10S,13S)-N-cyclopentyl-10-[2-(morpholin-4-yl)ethyl]-9,12-dioxo-13-(2-oxopyrrolidin-1-yl)-2-oxa-8,11-diazabicyclo[13.3.1]nonadeca-1(19),15,17-triene-7-carboxamide × 6	ELECTRON MICROSCOPY cryo-EM buffer：pH 7.5 cryo-EM vitrification conditions：Cryogen ETHANE	Resolution 2.18 Å

Other States of the Same Protein in the Database

No other PDB entry for the same UniProt protein was found.

View Construct and Data Evidence

UniProt name	A0A2I0BQ13_PLAFO
Isoform	—
PDB entities	2
Chains and sequence ranges	Author chain B； PDBConstruct 1–235； UniProt 1–235 Author chain P； PDBConstruct 1–235； UniProt 1–235

Proteasome subunit alpha type

OrganismNot specified

UniProt W7KN95

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein heterocomplex Heteromer Protein × 28 PDB declaration: 28-meric（28） Consistent with protein copy count	Chain C； UniProt 1–246 Chain Q； UniProt 1–246	Not recorded	Proteasome subunit alpha type-6 × 2 （W7JVP8） Proteasome subunit alpha type-2 × 2 （A0A2I0BQ13） Proteasome subunit alpha type × 2 （A0A2I0BS43） Proteasome subunit alpha type × 2 （A0A2I0BP34） Proteasome subunit alpha type-1 × 2 （W7K5W7） Proteasome subunit alpha type-3 × 2 （W7K040） Proteasome subunit beta type-6 × 2 （W7JUG8） Proteasome subunit beta × 2 （W7K1J4） Proteasome subunit beta × 2 （A0A2I0BXS0） Proteasome subunit beta × 2 （W7JKG5） Proteasome subunit beta × 2 （W7K6A8） Proteasome subunit beta × 2 （A0A2I0BU46） Proteasome subunit beta × 2 （W7K6I2） YRE (7S,10S,13S)-N-cyclopentyl-10-[2-(morpholin-4-yl)ethyl]-9,12-dioxo-13-(2-oxopyrrolidin-1-yl)-2-oxa-8,11-diazabicyclo[13.3.1]nonadeca-1(19),15,17-triene-7-carboxamide × 6	ELECTRON MICROSCOPY cryo-EM buffer：pH 7.5 cryo-EM vitrification conditions：Cryogen ETHANE	Resolution 2.18 Å

Other States of the Same Protein in the Database

No other PDB entry for the same UniProt protein was found.

View Construct and Data Evidence

UniProt name	W7KN95_PLAFO
Isoform	—
PDB entities	3
Chains and sequence ranges	Author chain C； PDBConstruct 1–246； UniProt 1–246 Author chain Q； PDBConstruct 1–246； UniProt 1–246

Proteasome subunit alpha type

OrganismNot specified

UniProt A0A2I0BS43

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein heterocomplex Heteromer Protein × 28 PDB declaration: 28-meric（28） Consistent with protein copy count	Chain D； UniProt 1–241 Chain R； UniProt 1–241	Not recorded	Proteasome subunit alpha type-6 × 2 （W7JVP8） Proteasome subunit alpha type-2 × 2 （A0A2I0BQ13） Proteasome subunit alpha type × 2 （W7KN95） Proteasome subunit alpha type × 2 （A0A2I0BP34） Proteasome subunit alpha type-1 × 2 （W7K5W7） Proteasome subunit alpha type-3 × 2 （W7K040） Proteasome subunit beta type-6 × 2 （W7JUG8） Proteasome subunit beta × 2 （W7K1J4） Proteasome subunit beta × 2 （A0A2I0BXS0） Proteasome subunit beta × 2 （W7JKG5） Proteasome subunit beta × 2 （W7K6A8） Proteasome subunit beta × 2 （A0A2I0BU46） Proteasome subunit beta × 2 （W7K6I2） YRE (7S,10S,13S)-N-cyclopentyl-10-[2-(morpholin-4-yl)ethyl]-9,12-dioxo-13-(2-oxopyrrolidin-1-yl)-2-oxa-8,11-diazabicyclo[13.3.1]nonadeca-1(19),15,17-triene-7-carboxamide × 6	ELECTRON MICROSCOPY cryo-EM buffer：pH 7.5 cryo-EM vitrification conditions：Cryogen ETHANE	Resolution 2.18 Å

Other States of the Same Protein in the Database

No other PDB entry for the same UniProt protein was found.

View Construct and Data Evidence

UniProt name	A0A2I0BS43_PLAFO
Isoform	—
PDB entities	4
Chains and sequence ranges	Author chain D； PDBConstruct 1–241； UniProt 1–241 Author chain R； PDBConstruct 1–241； UniProt 1–241

Proteasome subunit alpha type

OrganismNot specified

UniProt A0A2I0BP34

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein heterocomplex Heteromer Protein × 28 PDB declaration: 28-meric（28） Consistent with protein copy count	Chain E； UniProt 1–256 Chain S； UniProt 1–256	Not recorded	Proteasome subunit alpha type-6 × 2 （W7JVP8） Proteasome subunit alpha type-2 × 2 （A0A2I0BQ13） Proteasome subunit alpha type × 2 （W7KN95） Proteasome subunit alpha type × 2 （A0A2I0BS43） Proteasome subunit alpha type-1 × 2 （W7K5W7） Proteasome subunit alpha type-3 × 2 （W7K040） Proteasome subunit beta type-6 × 2 （W7JUG8） Proteasome subunit beta × 2 （W7K1J4） Proteasome subunit beta × 2 （A0A2I0BXS0） Proteasome subunit beta × 2 （W7JKG5） Proteasome subunit beta × 2 （W7K6A8） Proteasome subunit beta × 2 （A0A2I0BU46） Proteasome subunit beta × 2 （W7K6I2） YRE (7S,10S,13S)-N-cyclopentyl-10-[2-(morpholin-4-yl)ethyl]-9,12-dioxo-13-(2-oxopyrrolidin-1-yl)-2-oxa-8,11-diazabicyclo[13.3.1]nonadeca-1(19),15,17-triene-7-carboxamide × 6	ELECTRON MICROSCOPY cryo-EM buffer：pH 7.5 cryo-EM vitrification conditions：Cryogen ETHANE	Resolution 2.18 Å

Other States of the Same Protein in the Database

No other PDB entry for the same UniProt protein was found.

View Construct and Data Evidence

UniProt name	A0A2I0BP34_PLAFO
Isoform	—
PDB entities	5
Chains and sequence ranges	Author chain E； PDBConstruct 1–256； UniProt 1–256 Author chain S； PDBConstruct 1–256； UniProt 1–256

Proteasome subunit alpha type-1

OrganismNot specified

UniProt W7K5W7

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein heterocomplex Heteromer Protein × 28 PDB declaration: 28-meric（28） Consistent with protein copy count	Chain F； UniProt 1–253 Chain T； UniProt 1–253	Not recorded	Proteasome subunit alpha type-6 × 2 （W7JVP8） Proteasome subunit alpha type-2 × 2 （A0A2I0BQ13） Proteasome subunit alpha type × 2 （W7KN95） Proteasome subunit alpha type × 2 （A0A2I0BS43） Proteasome subunit alpha type × 2 （A0A2I0BP34） Proteasome subunit alpha type-3 × 2 （W7K040） Proteasome subunit beta type-6 × 2 （W7JUG8） Proteasome subunit beta × 2 （W7K1J4） Proteasome subunit beta × 2 （A0A2I0BXS0） Proteasome subunit beta × 2 （W7JKG5） Proteasome subunit beta × 2 （W7K6A8） Proteasome subunit beta × 2 （A0A2I0BU46） Proteasome subunit beta × 2 （W7K6I2） YRE (7S,10S,13S)-N-cyclopentyl-10-[2-(morpholin-4-yl)ethyl]-9,12-dioxo-13-(2-oxopyrrolidin-1-yl)-2-oxa-8,11-diazabicyclo[13.3.1]nonadeca-1(19),15,17-triene-7-carboxamide × 6	ELECTRON MICROSCOPY cryo-EM buffer：pH 7.5 cryo-EM vitrification conditions：Cryogen ETHANE	Resolution 2.18 Å

Other States of the Same Protein in the Database

No other PDB entry for the same UniProt protein was found.

View Construct and Data Evidence

UniProt name	W7K5W7_PLAFO
Isoform	—
PDB entities	6
Chains and sequence ranges	Author chain F； PDBConstruct 1–253； UniProt 1–253 Author chain T； PDBConstruct 1–253； UniProt 1–253

Proteasome subunit alpha type-3

OrganismNot specified

UniProt W7K040

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein heterocomplex Heteromer Protein × 28 PDB declaration: 28-meric（28） Consistent with protein copy count	Chain G； UniProt 1–252 Chain U； UniProt 1–252	Not recorded	Proteasome subunit alpha type-6 × 2 （W7JVP8） Proteasome subunit alpha type-2 × 2 （A0A2I0BQ13） Proteasome subunit alpha type × 2 （W7KN95） Proteasome subunit alpha type × 2 （A0A2I0BS43） Proteasome subunit alpha type × 2 （A0A2I0BP34） Proteasome subunit alpha type-1 × 2 （W7K5W7） Proteasome subunit beta type-6 × 2 （W7JUG8） Proteasome subunit beta × 2 （W7K1J4） Proteasome subunit beta × 2 （A0A2I0BXS0） Proteasome subunit beta × 2 （W7JKG5） Proteasome subunit beta × 2 （W7K6A8） Proteasome subunit beta × 2 （A0A2I0BU46） Proteasome subunit beta × 2 （W7K6I2） YRE (7S,10S,13S)-N-cyclopentyl-10-[2-(morpholin-4-yl)ethyl]-9,12-dioxo-13-(2-oxopyrrolidin-1-yl)-2-oxa-8,11-diazabicyclo[13.3.1]nonadeca-1(19),15,17-triene-7-carboxamide × 6	ELECTRON MICROSCOPY cryo-EM buffer：pH 7.5 cryo-EM vitrification conditions：Cryogen ETHANE	Resolution 2.18 Å

Other States of the Same Protein in the Database

No other PDB entry for the same UniProt protein was found.

View Construct and Data Evidence

UniProt name	W7K040_PLAFO
Isoform	—
PDB entities	7
Chains and sequence ranges	Author chain G； PDBConstruct 1–252； UniProt 1–252 Author chain U； PDBConstruct 1–252； UniProt 1–252

Proteasome subunit beta type-6

OrganismNot specified

UniProt W7JUG8

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein heterocomplex Heteromer Protein × 28 PDB declaration: 28-meric（28） Consistent with protein copy count	Chain H； UniProt 31–282 Chain V； UniProt 31–282	Not recorded	Proteasome subunit alpha type-6 × 2 （W7JVP8） Proteasome subunit alpha type-2 × 2 （A0A2I0BQ13） Proteasome subunit alpha type × 2 （W7KN95） Proteasome subunit alpha type × 2 （A0A2I0BS43） Proteasome subunit alpha type × 2 （A0A2I0BP34） Proteasome subunit alpha type-1 × 2 （W7K5W7） Proteasome subunit alpha type-3 × 2 （W7K040） Proteasome subunit beta × 2 （W7K1J4） Proteasome subunit beta × 2 （A0A2I0BXS0） Proteasome subunit beta × 2 （W7JKG5） Proteasome subunit beta × 2 （W7K6A8） Proteasome subunit beta × 2 （A0A2I0BU46） Proteasome subunit beta × 2 （W7K6I2） YRE (7S,10S,13S)-N-cyclopentyl-10-[2-(morpholin-4-yl)ethyl]-9,12-dioxo-13-(2-oxopyrrolidin-1-yl)-2-oxa-8,11-diazabicyclo[13.3.1]nonadeca-1(19),15,17-triene-7-carboxamide × 6	ELECTRON MICROSCOPY cryo-EM buffer：pH 7.5 cryo-EM vitrification conditions：Cryogen ETHANE	Resolution 2.18 Å

Other States of the Same Protein in the Database

No other PDB entry for the same UniProt protein was found.

View Construct and Data Evidence

UniProt name	W7JUG8_PLAFO
Isoform	—
PDB entities	8
Chains and sequence ranges	Author chain H； PDBConstruct 1–252； UniProt 31–282 Author chain V； PDBConstruct 1–252； UniProt 31–282

Proteasome subunit beta

OrganismNot specified

UniProt W7K1J4

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein heterocomplex Heteromer Protein × 28 PDB declaration: 28-meric（28） Consistent with protein copy count	Chain I； UniProt 42–270 Chain W； UniProt 42–270	Not recorded	Proteasome subunit alpha type-6 × 2 （W7JVP8） Proteasome subunit alpha type-2 × 2 （A0A2I0BQ13） Proteasome subunit alpha type × 2 （W7KN95） Proteasome subunit alpha type × 2 （A0A2I0BS43） Proteasome subunit alpha type × 2 （A0A2I0BP34） Proteasome subunit alpha type-1 × 2 （W7K5W7） Proteasome subunit alpha type-3 × 2 （W7K040） Proteasome subunit beta type-6 × 2 （W7JUG8） Proteasome subunit beta × 2 （A0A2I0BXS0） Proteasome subunit beta × 2 （W7JKG5） Proteasome subunit beta × 2 （W7K6A8） Proteasome subunit beta × 2 （A0A2I0BU46） Proteasome subunit beta × 2 （W7K6I2） YRE (7S,10S,13S)-N-cyclopentyl-10-[2-(morpholin-4-yl)ethyl]-9,12-dioxo-13-(2-oxopyrrolidin-1-yl)-2-oxa-8,11-diazabicyclo[13.3.1]nonadeca-1(19),15,17-triene-7-carboxamide × 6	ELECTRON MICROSCOPY cryo-EM buffer：pH 7.5 cryo-EM vitrification conditions：Cryogen ETHANE	Resolution 2.18 Å

Other States of the Same Protein in the Database

Other PDB	Difference from Current Entry 8G6E	Assembly / Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Non-polymers	Method and Experimental Conditions	Structure Quality
9Y0L Incorrectly assembled half-Pf20S Deposited 2025-08-28	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 15 PDB declaration: pentadecameric	Chain I 1–270（270 aa）	Not recorded	No recorded non-water small molecule	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.00 Å

1 other PDB entries and 1 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence

UniProt name	W7K1J4_PLAFO
Isoform	—
PDB entities	9
Chains and sequence ranges	Author chain I； PDBConstruct 1–229； UniProt 42–270 Author chain W； PDBConstruct 1–229； UniProt 42–270

Proteasome subunit beta

OrganismNot specified

UniProt A0A2I0BXS0

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein heterocomplex Heteromer Protein × 28 PDB declaration: 28-meric（28） Consistent with protein copy count	Chain J； UniProt 1–218 Chain X； UniProt 1–218	Not recorded	Proteasome subunit alpha type-6 × 2 （W7JVP8） Proteasome subunit alpha type-2 × 2 （A0A2I0BQ13） Proteasome subunit alpha type × 2 （W7KN95） Proteasome subunit alpha type × 2 （A0A2I0BS43） Proteasome subunit alpha type × 2 （A0A2I0BP34） Proteasome subunit alpha type-1 × 2 （W7K5W7） Proteasome subunit alpha type-3 × 2 （W7K040） Proteasome subunit beta type-6 × 2 （W7JUG8） Proteasome subunit beta × 2 （W7K1J4） Proteasome subunit beta × 2 （W7JKG5） Proteasome subunit beta × 2 （W7K6A8） Proteasome subunit beta × 2 （A0A2I0BU46） Proteasome subunit beta × 2 （W7K6I2） YRE (7S,10S,13S)-N-cyclopentyl-10-[2-(morpholin-4-yl)ethyl]-9,12-dioxo-13-(2-oxopyrrolidin-1-yl)-2-oxa-8,11-diazabicyclo[13.3.1]nonadeca-1(19),15,17-triene-7-carboxamide × 6	ELECTRON MICROSCOPY cryo-EM buffer：pH 7.5 cryo-EM vitrification conditions：Cryogen ETHANE	Resolution 2.18 Å

Other States of the Same Protein in the Database

No other PDB entry for the same UniProt protein was found.

View Construct and Data Evidence

UniProt name	A0A2I0BXS0_PLAFO
Isoform	—
PDB entities	10
Chains and sequence ranges	Author chain J； PDBConstruct 1–218； UniProt 1–218 Author chain X； PDBConstruct 1–218； UniProt 1–218

Proteasome subunit beta

OrganismNot specified

UniProt W7JKG5

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein heterocomplex Heteromer Protein × 28 PDB declaration: 28-meric（28） Consistent with protein copy count	Chain K； UniProt 1–195 Chain Y； UniProt 1–195	Not recorded	Proteasome subunit alpha type-6 × 2 （W7JVP8） Proteasome subunit alpha type-2 × 2 （A0A2I0BQ13） Proteasome subunit alpha type × 2 （W7KN95） Proteasome subunit alpha type × 2 （A0A2I0BS43） Proteasome subunit alpha type × 2 （A0A2I0BP34） Proteasome subunit alpha type-1 × 2 （W7K5W7） Proteasome subunit alpha type-3 × 2 （W7K040） Proteasome subunit beta type-6 × 2 （W7JUG8） Proteasome subunit beta × 2 （W7K1J4） Proteasome subunit beta × 2 （A0A2I0BXS0） Proteasome subunit beta × 2 （W7K6A8） Proteasome subunit beta × 2 （A0A2I0BU46） Proteasome subunit beta × 2 （W7K6I2） YRE (7S,10S,13S)-N-cyclopentyl-10-[2-(morpholin-4-yl)ethyl]-9,12-dioxo-13-(2-oxopyrrolidin-1-yl)-2-oxa-8,11-diazabicyclo[13.3.1]nonadeca-1(19),15,17-triene-7-carboxamide × 6	ELECTRON MICROSCOPY cryo-EM buffer：pH 7.5 cryo-EM vitrification conditions：Cryogen ETHANE	Resolution 2.18 Å

Other States of the Same Protein in the Database

No other PDB entry for the same UniProt protein was found.

View Construct and Data Evidence

UniProt name	W7JKG5_PLAFO
Isoform	—
PDB entities	11
Chains and sequence ranges	Author chain K； PDBConstruct 1–195； UniProt 1–195 Author chain Y； PDBConstruct 1–195； UniProt 1–195

Proteasome subunit beta

OrganismNot specified

UniProt W7K6A8

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein heterocomplex Heteromer Protein × 28 PDB declaration: 28-meric（28） Consistent with protein copy count	Chain L； UniProt 61–271 Chain Z； UniProt 61–271	Not recorded	Proteasome subunit alpha type-6 × 2 （W7JVP8） Proteasome subunit alpha type-2 × 2 （A0A2I0BQ13） Proteasome subunit alpha type × 2 （W7KN95） Proteasome subunit alpha type × 2 （A0A2I0BS43） Proteasome subunit alpha type × 2 （A0A2I0BP34） Proteasome subunit alpha type-1 × 2 （W7K5W7） Proteasome subunit alpha type-3 × 2 （W7K040） Proteasome subunit beta type-6 × 2 （W7JUG8） Proteasome subunit beta × 2 （W7K1J4） Proteasome subunit beta × 2 （A0A2I0BXS0） Proteasome subunit beta × 2 （W7JKG5） Proteasome subunit beta × 2 （A0A2I0BU46） Proteasome subunit beta × 2 （W7K6I2） YRE (7S,10S,13S)-N-cyclopentyl-10-[2-(morpholin-4-yl)ethyl]-9,12-dioxo-13-(2-oxopyrrolidin-1-yl)-2-oxa-8,11-diazabicyclo[13.3.1]nonadeca-1(19),15,17-triene-7-carboxamide × 6	ELECTRON MICROSCOPY cryo-EM buffer：pH 7.5 cryo-EM vitrification conditions：Cryogen ETHANE	Resolution 2.18 Å

Other States of the Same Protein in the Database

Other PDB	Difference from Current Entry 8G6E	Assembly / Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Non-polymers	Method and Experimental Conditions	Structure Quality
9Y0L Incorrectly assembled half-Pf20S Deposited 2025-08-28	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 15 PDB declaration: pentadecameric	Chain L 1–271（271 aa）	Not recorded	No recorded non-water small molecule	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.00 Å

1 other PDB entries and 1 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence

UniProt name	W7K6A8_PLAFO
Isoform	—
PDB entities	12
Chains and sequence ranges	Author chain L； PDBConstruct 1–211； UniProt 61–271 Author chain Z； PDBConstruct 1–211； UniProt 61–271

Proteasome subunit beta

OrganismNot specified

UniProt A0A2I0BU46

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein heterocomplex Heteromer Protein × 28 PDB declaration: 28-meric（28） Consistent with protein copy count	Chain M； UniProt 1–240 Chain a； UniProt 1–240	Not recorded	Proteasome subunit alpha type-6 × 2 （W7JVP8） Proteasome subunit alpha type-2 × 2 （A0A2I0BQ13） Proteasome subunit alpha type × 2 （W7KN95） Proteasome subunit alpha type × 2 （A0A2I0BS43） Proteasome subunit alpha type × 2 （A0A2I0BP34） Proteasome subunit alpha type-1 × 2 （W7K5W7） Proteasome subunit alpha type-3 × 2 （W7K040） Proteasome subunit beta type-6 × 2 （W7JUG8） Proteasome subunit beta × 2 （W7K1J4） Proteasome subunit beta × 2 （A0A2I0BXS0） Proteasome subunit beta × 2 （W7JKG5） Proteasome subunit beta × 2 （W7K6A8） Proteasome subunit beta × 2 （W7K6I2） YRE (7S,10S,13S)-N-cyclopentyl-10-[2-(morpholin-4-yl)ethyl]-9,12-dioxo-13-(2-oxopyrrolidin-1-yl)-2-oxa-8,11-diazabicyclo[13.3.1]nonadeca-1(19),15,17-triene-7-carboxamide × 6	ELECTRON MICROSCOPY cryo-EM buffer：pH 7.5 cryo-EM vitrification conditions：Cryogen ETHANE	Resolution 2.18 Å

Other States of the Same Protein in the Database

Other PDB	Difference from Current Entry 8G6E	Assembly / Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Non-polymers	Method and Experimental Conditions	Structure Quality
8G6F Structure of the Plasmodium falciparum 20S proteasome beta-6 A117D mutant complexed with inhibitor WLW-vs Deposited 2023-02-15	Different mutation/modification Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric	Chain M 1–240（240 aa） Chain a 1–240（240 aa）	Mutation：A117D Mutation：A117D	7F1 (2S)-N-[(E,2S)-1-(1H-indol-3-yl)-4-methylsulfonyl-but-3-en-2-yl]-2-[[(2S)-3-(1H-indol-3-yl)-2-(2-morpholin-4-ylethanoylamino)propanoyl]amino]-4-methyl-pentanamide × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.58 Å
9Y0K Structure of Plasmodium falciparum 20S proteasome with bound J80 Deposited 2025-08-28	Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric	Chain M 1–240（240 aa） Chain a 1–240（240 aa）	Not recorded	A1CRO N,N-diethyl-N~2~-hexanoyl-D-asparaginyl-N-{(1S)-2-(2,4-difluorophenyl)-1-[(2S,3S,5S,6S)-5-formyl-2-hydroxy-3-(hydroxymethyl)-3,6-dimethylmorpholin-2-yl]ethyl}-4-fluoro-L-phenylalaninamide × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.00 Å
9Y0L Incorrectly assembled half-Pf20S Deposited 2025-08-28	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 15 PDB declaration: pentadecameric	Chain M 1–240（240 aa）	Not recorded	No recorded non-water small molecule	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.00 Å
9Y1O The structure of the Plasmodium falciparum 20S proteasome Deposited 2025-08-29	Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric	Chain M 1–240（240 aa） Chain a 1–240（240 aa）	Not recorded	No recorded non-water small molecule	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.10 Å

4 other PDB entries and 4 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence

UniProt name	A0A2I0BU46_PLAFO
Isoform	—
PDB entities	13
Chains and sequence ranges	Author chain M； PDBConstruct 1–240； UniProt 1–240 Author chain a； PDBConstruct 1–240； UniProt 1–240

Proteasome subunit beta

OrganismNot specified

UniProt W7K6I2

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein heterocomplex Heteromer Protein × 28 PDB declaration: 28-meric（28） Consistent with protein copy count	Chain N； UniProt 1–265 Chain b； UniProt 1–265	Not recorded	Proteasome subunit alpha type-6 × 2 （W7JVP8） Proteasome subunit alpha type-2 × 2 （A0A2I0BQ13） Proteasome subunit alpha type × 2 （W7KN95） Proteasome subunit alpha type × 2 （A0A2I0BS43） Proteasome subunit alpha type × 2 （A0A2I0BP34） Proteasome subunit alpha type-1 × 2 （W7K5W7） Proteasome subunit alpha type-3 × 2 （W7K040） Proteasome subunit beta type-6 × 2 （W7JUG8） Proteasome subunit beta × 2 （W7K1J4） Proteasome subunit beta × 2 （A0A2I0BXS0） Proteasome subunit beta × 2 （W7JKG5） Proteasome subunit beta × 2 （W7K6A8） Proteasome subunit beta × 2 （A0A2I0BU46） YRE (7S,10S,13S)-N-cyclopentyl-10-[2-(morpholin-4-yl)ethyl]-9,12-dioxo-13-(2-oxopyrrolidin-1-yl)-2-oxa-8,11-diazabicyclo[13.3.1]nonadeca-1(19),15,17-triene-7-carboxamide × 6	ELECTRON MICROSCOPY cryo-EM buffer：pH 7.5 cryo-EM vitrification conditions：Cryogen ETHANE	Resolution 2.18 Å

Other States of the Same Protein in the Database

No other PDB entry for the same UniProt protein was found.

View Construct and Data Evidence

UniProt name	W7K6I2_PLAFO
Isoform	—
PDB entities	14
Chains and sequence ranges	Author chain N； PDBConstruct 1–265； UniProt 1–265 Author chain b； PDBConstruct 1–265； UniProt 1–265

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

SAXS scattering curve SAXS Profile

P(r) Distance Distribution P(r) Distribution

Download Download SAXS (.dat) P(r) (.pr.out) CIF

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2. Structure Basics 2. Structure Basics

Entry ID entry_id	8g6e
Deposition date deposition_date	2023-02-15
Structure title title	Structure of the Plasmodium falciparum 20S proteasome complexed with inhibitor TDI-8304
Keywords keywords	proteasome, inhibitor, 20S, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR complex; HYDROLASE/HYDROLASE INHIBITOR
Experimental Method method	ELECTRON MICROSCOPY

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3. SAXS Parameters (CRYSOL theoretical calculation) 3. SAXS Parameters (CRYSOL)

Radius of gyration Rg (Guinier) rg_guinier	60.25 Å
Radius of gyration Rg (electron density) rg_electron	59.76 Å
Forward intensity I(0) i0	7400530000.00
Molecular weight molecular_weight	739420.0 kDa
Excluded volume excluded_volume	929780 Å³
Envelope volume envelope_volume	1292800 Å³
Hydration-shell volume shell_volume	172050 Å³
Envelope diameter envelope_diameter	197.3 Å
Shell Rg shell_rg	68.54 Å
Envelope Rg envelope_rg	58.00 Å
Shape Rg shape_rg	59.73 Å
Total Rg total_rg	60.03 Å
Total atoms total_atoms	52006
Residues n_residues	6490
Spherical-harmonic order n_harmonics	20
q range q_range	— – 0.5000 Å⁻¹
Data points n_points	101
Shell type shell_type	directional
Solvent electron density solvent_density	0.3340 e/Å³
Shell contrast contrast_shell	0.0300 e/Å³
CRYSOL version crysol_version	4.1.3

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4. P(r) Distance Distribution (GNOM inversion) 4. P(r) Analysis (GNOM)

Maximum dimension Dmax dmax	196.5 Å
Rg (real space) rg_real	59.94 Å
Rg uncertainty (real space) rg_real_error	1.60 Å
I(0) (real space) i0_real	7.4000e+09
I(0) uncertainty (real space) i0_real_error	1.6970e+08
Rg (reciprocal space) rg_reciprocal	60.48 Å
I(0) (reciprocal space) i0_reciprocal	7407000000.0000
Solution quality estimate total_estimate	0.8597
Solution quality rating solution_quality	GOOD a GOOD solution
P(r) peaks n_peaks	1
Primary peak position r_peak_primary	75.6 Å
Skewness Skewness skewness	0.196
Kurtosis Kurtosis kurtosis	-0.417
Angular range angular_range	— – 0.1300 Å⁻¹
Current regularization parameter α current_alpha	0.0000
Highest regularization parameter α highest_alpha	1209000000.0000
Real-space data points n_real_points	27
GNOM version gnom_version	4.1.3
Quality Criteria quality_criteria	AN1: 0.000; Oscil: 0.796; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.950; Smooth: 0.835

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5. Crystallography and Experiment 5. Crystallography & Experiment

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6. Entities and Polymers Entities & Polymers (16)

Entity 1 Entity 1 polymer

Description description	Proteasome subunit alpha type-6
Molecular weight formula_weight	29531.7 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	A,O
Atom count atom_count	52266

MVRPSQSMYDRHLTIFSPDGNLYQIEYAIKAVKNTNITSVGVKGENCAVIISQKKMATQYISQDKLLDYNNITNIYNITDEIGCSMVGMPGDCLSMVYKARSEASEFLYSNGYNVNAETLCRNICDKIQVYTQHAYMRLHACSGMIIGIDENNKPELFKFDPSGFCAGYRACVIGNKEQESISVLERLLEKRKKKIQQETIDEDIRNTTILAIEALQTILAFDLKASEIEVAIVSTKNRNFTQISEKEIDNYLTYIAERD

Entity 2 Entity 2 polymer

Description description	Proteasome subunit alpha type-2
Molecular weight formula_weight	26556.4 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	B,P

MADGEYSFSLTTFSPTGKLVQIEYALNRVSSSSPALGIRAKNGVIIATEKKSPNELIEENSIFKIQQISEHIGIVYAGMPGDFRVLLKRARKEAIRYSLQYGSEILVKELVKIIASIVQEFTQTGGVRPFGLSLLICGVDVYGYHLYQIDPSGCYFNWMATCVGKDYQNNMSFLEKRYNKDIEIEDAIHTAILTLKESYEGVLNEKNIEIGVAYDNKPFKILTQNEIKDYLIEIE

Entity 3 Entity 3 polymer

Description description	Proteasome subunit alpha type
Molecular weight formula_weight	27977.7 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	C,Q

MARRYDSRTTTFSPEGRLYQVEYALEAINNASITIGLITKDGVILGADKVFISKLIDKANNYEKIYKIDKHIFCGVAGLNADANILINQSRLYAQRYLYNYNEVQPVSQLVVQICDIKQSYTQYGGLRPYGVSFLIGGYDTKDGYQLYHTDPSGNYSGWFATAIGTNNLTASSVLKQEWKNDMTLEEGLLLALKTLAKSTDTEIPKSEKIELAYLTNKDGEVYQKYLTEKEIEELIKLYTQKYIKE

Entity 4 Entity 4 polymer

Description description	Proteasome subunit alpha type
Molecular weight formula_weight	27263.3 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	D,R

MSYDRAITVFSPDGHLLQVEHALEAVKKGGCAVAIKSSNFAVLAVEKKNIPKLQNPKTTEKLIKLDEHNCLAFAGLNADARVLVNKTRLECQRYYLNMDEPAPVDYIAKYVAKVQQKFTHRGGVRPFGIATLIAGFKNNKEICIYQTEPSGIYAAWKAQAIGKNAKIVQEFLEKNYQENMEQKDCIFLALKAIFEVVELSSKNVEVALLTEKDLTFIEEQEINSMVELIDQERTKNNEQNE

Entity 5 Entity 5 polymer

Description description	Proteasome subunit alpha type
Molecular weight formula_weight	28417.4 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	E,S

MFSTRSEYDRGVNTFSPEGRLFQVEYALGAIKLGSTAVGICVNDGVILASERRISSTLIEKDSVEKLLSIDDHIGCAMSGLMADARTLIDYARVECNHYKFIYNENINIKSCVELISELALDFSNLSDSKRKKIMSRPFGVALLIGGVDKNGPCLWYTEPSGTNTRFSAASIGSAQEGAELLLQENYKKDMTFEQAEILALTVLRQVMEDKLSTSNVEICAIKKSDQTFYKYNTDDISRIIDVLPSPVYPTIDMTA

Entity 6 Entity 6 polymer

Description description	Proteasome subunit alpha type-1
Molecular weight formula_weight	28742.6 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	F,T

MYRNLYDTDNIIYSPEGRLYQVEYASEAIKQGTCAVAIKSKDYVVVSGLKKCISKLSFPQEKIFKIDDYIGISMSGITSDAKVLTKFMQNECLSHKFLYNENINIESLVRSVADKYQKNTQKSSKRAFGVGLMIAAYHNEPCIFETRPNGSYFEYDALSFGARSHASKTYLEKNLHLFEECSLEELILHCLKALKCSLSSESELTISNTALAVVGKNHPWQEISSLQLEEYLSKVKMDAEQEQVEENVQNEAN

Entity 7 Entity 7 polymer

Description description	Proteasome subunit alpha type-3
Molecular weight formula_weight	29324.3 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	G,U

MAGLSAGYDLSVSTFSPDGRLYQVEYIYKSINNNNTALCLECKDGIICCCINSNMDKNKMIKKNSYNRIYHVNNNIIITYSGFDGDARNIIDRARSEANTYYYNFHTNIPLHILVNRISLYIHAYTLYWHMRPFAASIIISSFNEKDKGDIYCIEPNGACYKYSGIVIGKNKEMFKTEIEKKDYKDINVRDAIEDIYKFILTSDDHMNKNNLQNLVNFSWICKESSYEFQNIHEEILTPALNKAVEYIEKLN

Entity 8 Entity 8 polymer

Description description	Proteasome subunit beta type-6
Molecular weight formula_weight	29143.9 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	H,V

TTIIGIIYDNGVMLACDSRTSSGTFISNKCSRKINRINENLYVCRSGASAHSQKIIEIIKHYCVSMKNENRKKGRFHEGETIYDETTYDEEIDIDSINYLDYNNNNDNNLVTKNKYFYEDKFNDYNPLVENVAHITKKIIYTNNNFLSCALIFGGYDKIKKQQLYAVNLNGSIIEKHDFAVSGSGSIYIQSYLQDKYKKFMTKKECFNLILNCVKYAMHNDNSSGGLIRIVNITKSFVEEFTVVNTQMNFQY

Entity 9 Entity 9 polymer

Description description	Proteasome subunit beta
Molecular weight formula_weight	25104.9 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	I,W

TTICGLVCQNAVILGADTRATEGPIVADKNCSKLHYISKNIWCAGAGVAGDLEHTTLWLQHNVELHRLNTNTQPRVSMCVSRLTQELFKYQGYKVCAIVLGGVDVNGPQLYGIHPHGSSCLLPFTALGSGSLNAMAVLEAKYRDNMTIEEGKNLVCEAICAGIFNDLGSGGNVDICVITKDSYQHIRPYKEPNMRLYHLPHPTIYPKGTTPILSEKIEYIKKFISVEDA

Entity 10 Entity 10 polymer

Description description	Proteasome subunit beta
Molecular weight formula_weight	24533.1 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	J,X

MGSIYNYNGGCVLGMSGSNCVAIACDLRLGANTFTTVSTKFSKIFKMNNNVYVGLSGLATDIQTLYEILRYRVNLYEVRQDAEMDVECFANMLSSILYSNRFSPYFVNPIVVGFKLKHYVDEEGEKKVNYEPYLTAYDLIGAKCETRDFVVNGVTSEQLFGMCESLYVKDQDENGLFETISQCLLSALDRDCISGWGAEVLVLTPEKIIKKKLKARMD

Entity 11 Entity 11 polymer

Description description	Proteasome subunit beta
Molecular weight formula_weight	22889.1 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	K,Y

MDTLIGLRGNNFVVLAADTYSINSIIKLKNDDNTKFYDIHGNKCLLLGGSIGDRLQFGEFIRKNVHLYQYQNNTDMFVKSFAFFTRKNLAYYLRRNPFEVNCLIAGYDKKDGYQLYWCDYLSNMDSVNKGAHGYGAYLVSAILDKYYHENLTVDEALDIFKLCFEELKKRFLLTQINYELRIMYDNKVETQYVTV

Entity 12 Entity 12 polymer

Description description	Proteasome subunit beta
Molecular weight formula_weight	23620.6 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	L,Z

TTTLAFKFKDGIIVAVDSRASMGSFISSQNVEKIIEINKNILGTMAGGAADCLYWEKYLGKIIKIYELRNNEKISVRAASTILSNILYQYKGYGLCCGIILSGYDHTGFNMFYVDDSGKKVEGNLFSCGSGSTYAYSILDSAYDYNLNLDQAVELARNAIYHATFRDGGSGGKVRVFHIHKNGYDKIIEGEDVFDLHYHYTNPEQKDQYVM

Entity 13 Entity 13 polymer

Description description	Proteasome subunit beta
Molecular weight formula_weight	27301.2 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	M,a

MDLILYNDNLTEKKTEKENVIEHGRGFKRWYPYIDNGGTVIGLTGKDYVILAADTRLSLSYSIYTRFCPKISKLTDKCIIGSSGMQSDIKTLHSLLQKKIQLFVLEHSHYPDIHVIARLLCVILYSRRFFPYYAFNILAGVDENNKGVLYNYDSVGSYCEATHSCVGSGSQLILPILDNRVEQKNQLIKNTNFNLGDDINFVKDAITSATERDIYTGDKTLIYVIDKMGINVNTLDLKQD

Entity 14 Entity 14 polymer

Description description	Proteasome subunit beta
Molecular weight formula_weight	30909.9 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	N,b

MTLGPVVTGTSVIAIKYKHGIMIAADRKASYGSYAKFQNVERIFKINNKTVMGFSGELADAQYLHELLTRKNINNLSEKKRKEDMYTPQHYHSYVSRVFYVRKNRIDPLFNNIIIAGINSQKYDNNDDNVLLYTNKNNDDEQNEYKNNEEYKEIHKDDLYIGFVDMHGTNFCDDYITTGYARYFALTLLRDHYKDNMTEEEARILINECLRILYFRDATSSNFIQIVKVTSKGVEYEEPYILPCVLNSADYVYPSTLLPPAGCMW

Entity 15 Entity 15 non-polymer

Description description	;(7S,10S,13S)-N-cyclopentyl-10-[2-(morpholin-4-yl)ethyl]-9,12-dioxo-13-(2-oxopyrrolidin-1-yl)-2-oxa-8,11-diazabicyclo[13.3.1]nonadeca-1(19),15,17-triene-7-carboxamide ;
Molecular weight formula_weight	597.7 kDa
Source method src_method	syn
Copy count entity_count	6

Entity 16 Entity 16 water

Description description	water
Molecular weight formula_weight	18.0 kDa
Source method src_method	nat
Copy count entity_count	218

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8. Citations (1)

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Unit-cell length a length_a	1.000 Å
Unit-cell length b length_b	1.000 Å
Unit-cell length c length_c	1.000 Å
Unit-cell angle α angle_alpha	90.00 °
Unit-cell angle β angle_beta	90.00 °
Unit-cell angle γ angle_gamma	90.00 °
Molecules per unit cell Z z_pdb	—

Space group space_group	P 1
Space-group number int_tables_number	1
Crystal system crystal_system	—

Resolution resolution	2.18 Å
Resolution测定方法 resolution_method	—
颗粒数 num_particles	305581

fit	/app/data/saxs_computation/g6/8g6e/8g6e.fit
pddf	/app/data/pr_computation/g6/8g6e/8g6e.pr.out
profile	/app/data/saxs_computation/g6/8g6e/8g6e.dat

Structure of the Plasmodium falciparum 20S proteasome complexed with inhibitor TDI-8304

1. Protein Identity and Related Structures Protein Identity & Related Structures

Proteasome subunit alpha type-6

State in the Current Structure

Other States of the Same Protein in the Database

Proteasome subunit alpha type-2

State in the Current Structure

Other States of the Same Protein in the Database

Proteasome subunit alpha type

State in the Current Structure

Other States of the Same Protein in the Database

Proteasome subunit alpha type

State in the Current Structure

Other States of the Same Protein in the Database

Proteasome subunit alpha type

State in the Current Structure

Other States of the Same Protein in the Database

Proteasome subunit alpha type-1

State in the Current Structure

Other States of the Same Protein in the Database

Proteasome subunit alpha type-3

State in the Current Structure

Other States of the Same Protein in the Database

Proteasome subunit beta type-6

State in the Current Structure

Other States of the Same Protein in the Database

Proteasome subunit beta

State in the Current Structure

Other States of the Same Protein in the Database

Proteasome subunit beta

State in the Current Structure

Other States of the Same Protein in the Database

Proteasome subunit beta

State in the Current Structure

Other States of the Same Protein in the Database

Proteasome subunit beta

State in the Current Structure

Other States of the Same Protein in the Database

Proteasome subunit beta

State in the Current Structure

Other States of the Same Protein in the Database

Proteasome subunit beta

State in the Current Structure

Other States of the Same Protein in the Database

SAXS scattering curve SAXS Profile

P(r) Distance Distribution P(r) Distribution

2. Structure Basics 2. Structure Basics

3. SAXS Parameters (CRYSOL theoretical calculation) 3. SAXS Parameters (CRYSOL)

4. P(r) Distance Distribution (GNOM inversion) 4. P(r) Analysis (GNOM)

5. Crystallography and Experiment 5. Crystallography & Experiment

Unit cell Unit Cell

Symmetry Symmetry

冷冻电镜 EM 3D

6. Entities and Polymers Entities & Polymers (16)

Entity 1 Entity 1 polymer

Polymer Polymer

Entity 2 Entity 2 polymer

Polymer Polymer

Entity 3 Entity 3 polymer

Polymer Polymer

Entity 4 Entity 4 polymer

Polymer Polymer

Entity 5 Entity 5 polymer

Polymer Polymer

Entity 6 Entity 6 polymer

Polymer Polymer

Entity 7 Entity 7 polymer

Polymer Polymer

Entity 8 Entity 8 polymer

Polymer Polymer

Entity 9 Entity 9 polymer

Polymer Polymer

Entity 10 Entity 10 polymer

Polymer Polymer

Entity 11 Entity 11 polymer

Polymer Polymer

Entity 12 Entity 12 polymer

Polymer Polymer

Entity 13 Entity 13 polymer

Polymer Polymer