8g6e

Structure of the Plasmodium falciparum 20S proteasome complexed with inhibitor TDI-8304

Method: ELECTRON MICROSCOPY

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1. Protein Identity and Related Structures Protein Identity & Related Structures

Proteasome subunit alpha type-6

OrganismNot specified

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 28	Proteasome subunit alpha type-2 × 2 （A0A2I0BQ13） Proteasome subunit alpha type × 2 （W7KN95） Proteasome subunit alpha type × 2 （A0A2I0BS43） Proteasome subunit alpha type × 2 （A0A2I0BP34） Proteasome subunit alpha type-1 × 2 （W7K5W7） Proteasome subunit alpha type-3 × 2 （W7K040） Proteasome subunit beta type-6 × 2 （W7JUG8） Proteasome subunit beta × 2 （W7K1J4） Proteasome subunit beta × 2 （A0A2I0BXS0） Proteasome subunit beta × 2 （W7JKG5） Proteasome subunit beta × 2 （W7K6A8） Proteasome subunit beta × 2 （A0A2I0BU46） Proteasome subunit beta × 2 （W7K6I2） ;(7S,10S,13S)-N-cyclopentyl-10-[2-(morpholin-4-yl)ethyl]-9,12-dioxo-13-(2-oxopyrrolidin-1-yl)-2-oxa-8,11-diazabicyclo[13.3.1]nonadeca-1(19),15,17-triene-7-carboxamide ; × 6 water × 28	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	W7JVP8_PLAFO
Isoform	—
PDB entities	1
Chains and sequence ranges	Author chain A； PDBConstruct 1–260； UniProt 1–260 Author chain O； PDBConstruct 1–260； UniProt 1–260

Proteasome subunit alpha type-2

OrganismNot specified

UniProt A0A2I0BQ13

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 28	Proteasome subunit alpha type-6 × 2 （W7JVP8） Proteasome subunit alpha type × 2 （W7KN95） Proteasome subunit alpha type × 2 （A0A2I0BS43） Proteasome subunit alpha type × 2 （A0A2I0BP34） Proteasome subunit alpha type-1 × 2 （W7K5W7） Proteasome subunit alpha type-3 × 2 （W7K040） Proteasome subunit beta type-6 × 2 （W7JUG8） Proteasome subunit beta × 2 （W7K1J4） Proteasome subunit beta × 2 （A0A2I0BXS0） Proteasome subunit beta × 2 （W7JKG5） Proteasome subunit beta × 2 （W7K6A8） Proteasome subunit beta × 2 （A0A2I0BU46） Proteasome subunit beta × 2 （W7K6I2） ;(7S,10S,13S)-N-cyclopentyl-10-[2-(morpholin-4-yl)ethyl]-9,12-dioxo-13-(2-oxopyrrolidin-1-yl)-2-oxa-8,11-diazabicyclo[13.3.1]nonadeca-1(19),15,17-triene-7-carboxamide ; × 6 water × 28	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	A0A2I0BQ13_PLAFO
Isoform	—
PDB entities	2
Chains and sequence ranges	Author chain B； PDBConstruct 1–235； UniProt 1–235 Author chain P； PDBConstruct 1–235； UniProt 1–235

Proteasome subunit alpha type

OrganismNot specified

UniProt W7KN95

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 28	Proteasome subunit alpha type-6 × 2 （W7JVP8） Proteasome subunit alpha type-2 × 2 （A0A2I0BQ13） Proteasome subunit alpha type × 2 （A0A2I0BS43） Proteasome subunit alpha type × 2 （A0A2I0BP34） Proteasome subunit alpha type-1 × 2 （W7K5W7） Proteasome subunit alpha type-3 × 2 （W7K040） Proteasome subunit beta type-6 × 2 （W7JUG8） Proteasome subunit beta × 2 （W7K1J4） Proteasome subunit beta × 2 （A0A2I0BXS0） Proteasome subunit beta × 2 （W7JKG5） Proteasome subunit beta × 2 （W7K6A8） Proteasome subunit beta × 2 （A0A2I0BU46） Proteasome subunit beta × 2 （W7K6I2） ;(7S,10S,13S)-N-cyclopentyl-10-[2-(morpholin-4-yl)ethyl]-9,12-dioxo-13-(2-oxopyrrolidin-1-yl)-2-oxa-8,11-diazabicyclo[13.3.1]nonadeca-1(19),15,17-triene-7-carboxamide ; × 6 water × 28	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	W7KN95_PLAFO
Isoform	—
PDB entities	3
Chains and sequence ranges	Author chain C； PDBConstruct 1–246； UniProt 1–246 Author chain Q； PDBConstruct 1–246； UniProt 1–246

Proteasome subunit alpha type

OrganismNot specified

UniProt A0A2I0BS43

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 28	Proteasome subunit alpha type-6 × 2 （W7JVP8） Proteasome subunit alpha type-2 × 2 （A0A2I0BQ13） Proteasome subunit alpha type × 2 （W7KN95） Proteasome subunit alpha type × 2 （A0A2I0BP34） Proteasome subunit alpha type-1 × 2 （W7K5W7） Proteasome subunit alpha type-3 × 2 （W7K040） Proteasome subunit beta type-6 × 2 （W7JUG8） Proteasome subunit beta × 2 （W7K1J4） Proteasome subunit beta × 2 （A0A2I0BXS0） Proteasome subunit beta × 2 （W7JKG5） Proteasome subunit beta × 2 （W7K6A8） Proteasome subunit beta × 2 （A0A2I0BU46） Proteasome subunit beta × 2 （W7K6I2） ;(7S,10S,13S)-N-cyclopentyl-10-[2-(morpholin-4-yl)ethyl]-9,12-dioxo-13-(2-oxopyrrolidin-1-yl)-2-oxa-8,11-diazabicyclo[13.3.1]nonadeca-1(19),15,17-triene-7-carboxamide ; × 6 water × 28	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	A0A2I0BS43_PLAFO
Isoform	—
PDB entities	4
Chains and sequence ranges	Author chain D； PDBConstruct 1–241； UniProt 1–241 Author chain R； PDBConstruct 1–241； UniProt 1–241

Proteasome subunit alpha type

OrganismNot specified

UniProt A0A2I0BP34

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 28	Proteasome subunit alpha type-6 × 2 （W7JVP8） Proteasome subunit alpha type-2 × 2 （A0A2I0BQ13） Proteasome subunit alpha type × 2 （W7KN95） Proteasome subunit alpha type × 2 （A0A2I0BS43） Proteasome subunit alpha type-1 × 2 （W7K5W7） Proteasome subunit alpha type-3 × 2 （W7K040） Proteasome subunit beta type-6 × 2 （W7JUG8） Proteasome subunit beta × 2 （W7K1J4） Proteasome subunit beta × 2 （A0A2I0BXS0） Proteasome subunit beta × 2 （W7JKG5） Proteasome subunit beta × 2 （W7K6A8） Proteasome subunit beta × 2 （A0A2I0BU46） Proteasome subunit beta × 2 （W7K6I2） ;(7S,10S,13S)-N-cyclopentyl-10-[2-(morpholin-4-yl)ethyl]-9,12-dioxo-13-(2-oxopyrrolidin-1-yl)-2-oxa-8,11-diazabicyclo[13.3.1]nonadeca-1(19),15,17-triene-7-carboxamide ; × 6 water × 28	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	A0A2I0BP34_PLAFO
Isoform	—
PDB entities	5
Chains and sequence ranges	Author chain E； PDBConstruct 1–256； UniProt 1–256 Author chain S； PDBConstruct 1–256； UniProt 1–256

Proteasome subunit alpha type-1

OrganismNot specified

UniProt W7K5W7

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 28	Proteasome subunit alpha type-6 × 2 （W7JVP8） Proteasome subunit alpha type-2 × 2 （A0A2I0BQ13） Proteasome subunit alpha type × 2 （W7KN95） Proteasome subunit alpha type × 2 （A0A2I0BS43） Proteasome subunit alpha type × 2 （A0A2I0BP34） Proteasome subunit alpha type-3 × 2 （W7K040） Proteasome subunit beta type-6 × 2 （W7JUG8） Proteasome subunit beta × 2 （W7K1J4） Proteasome subunit beta × 2 （A0A2I0BXS0） Proteasome subunit beta × 2 （W7JKG5） Proteasome subunit beta × 2 （W7K6A8） Proteasome subunit beta × 2 （A0A2I0BU46） Proteasome subunit beta × 2 （W7K6I2） ;(7S,10S,13S)-N-cyclopentyl-10-[2-(morpholin-4-yl)ethyl]-9,12-dioxo-13-(2-oxopyrrolidin-1-yl)-2-oxa-8,11-diazabicyclo[13.3.1]nonadeca-1(19),15,17-triene-7-carboxamide ; × 6 water × 28	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	W7K5W7_PLAFO
Isoform	—
PDB entities	6
Chains and sequence ranges	Author chain F； PDBConstruct 1–253； UniProt 1–253 Author chain T； PDBConstruct 1–253； UniProt 1–253

Proteasome subunit alpha type-3

OrganismNot specified

UniProt W7K040

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 28	Proteasome subunit alpha type-6 × 2 （W7JVP8） Proteasome subunit alpha type-2 × 2 （A0A2I0BQ13） Proteasome subunit alpha type × 2 （W7KN95） Proteasome subunit alpha type × 2 （A0A2I0BS43） Proteasome subunit alpha type × 2 （A0A2I0BP34） Proteasome subunit alpha type-1 × 2 （W7K5W7） Proteasome subunit beta type-6 × 2 （W7JUG8） Proteasome subunit beta × 2 （W7K1J4） Proteasome subunit beta × 2 （A0A2I0BXS0） Proteasome subunit beta × 2 （W7JKG5） Proteasome subunit beta × 2 （W7K6A8） Proteasome subunit beta × 2 （A0A2I0BU46） Proteasome subunit beta × 2 （W7K6I2） ;(7S,10S,13S)-N-cyclopentyl-10-[2-(morpholin-4-yl)ethyl]-9,12-dioxo-13-(2-oxopyrrolidin-1-yl)-2-oxa-8,11-diazabicyclo[13.3.1]nonadeca-1(19),15,17-triene-7-carboxamide ; × 6 water × 28	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	W7K040_PLAFO
Isoform	—
PDB entities	7
Chains and sequence ranges	Author chain G； PDBConstruct 1–252； UniProt 1–252 Author chain U； PDBConstruct 1–252； UniProt 1–252

Proteasome subunit beta type-6

OrganismNot specified

UniProt W7JUG8

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 28	Proteasome subunit alpha type-6 × 2 （W7JVP8） Proteasome subunit alpha type-2 × 2 （A0A2I0BQ13） Proteasome subunit alpha type × 2 （W7KN95） Proteasome subunit alpha type × 2 （A0A2I0BS43） Proteasome subunit alpha type × 2 （A0A2I0BP34） Proteasome subunit alpha type-1 × 2 （W7K5W7） Proteasome subunit alpha type-3 × 2 （W7K040） Proteasome subunit beta × 2 （W7K1J4） Proteasome subunit beta × 2 （A0A2I0BXS0） Proteasome subunit beta × 2 （W7JKG5） Proteasome subunit beta × 2 （W7K6A8） Proteasome subunit beta × 2 （A0A2I0BU46） Proteasome subunit beta × 2 （W7K6I2） ;(7S,10S,13S)-N-cyclopentyl-10-[2-(morpholin-4-yl)ethyl]-9,12-dioxo-13-(2-oxopyrrolidin-1-yl)-2-oxa-8,11-diazabicyclo[13.3.1]nonadeca-1(19),15,17-triene-7-carboxamide ; × 6 water × 28	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	W7JUG8_PLAFO
Isoform	—
PDB entities	8
Chains and sequence ranges	Author chain H； PDBConstruct 1–252； UniProt 31–282 Author chain V； PDBConstruct 1–252； UniProt 31–282

Proteasome subunit beta

OrganismNot specified

UniProt W7K1J4

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 28	Proteasome subunit alpha type-6 × 2 （W7JVP8） Proteasome subunit alpha type-2 × 2 （A0A2I0BQ13） Proteasome subunit alpha type × 2 （W7KN95） Proteasome subunit alpha type × 2 （A0A2I0BS43） Proteasome subunit alpha type × 2 （A0A2I0BP34） Proteasome subunit alpha type-1 × 2 （W7K5W7） Proteasome subunit alpha type-3 × 2 （W7K040） Proteasome subunit beta type-6 × 2 （W7JUG8） Proteasome subunit beta × 2 （A0A2I0BXS0） Proteasome subunit beta × 2 （W7JKG5） Proteasome subunit beta × 2 （W7K6A8） Proteasome subunit beta × 2 （A0A2I0BU46） Proteasome subunit beta × 2 （W7K6I2） ;(7S,10S,13S)-N-cyclopentyl-10-[2-(morpholin-4-yl)ethyl]-9,12-dioxo-13-(2-oxopyrrolidin-1-yl)-2-oxa-8,11-diazabicyclo[13.3.1]nonadeca-1(19),15,17-triene-7-carboxamide ; × 6 water × 28	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	W7K1J4_PLAFO
Isoform	—
PDB entities	9
Chains and sequence ranges	Author chain I； PDBConstruct 1–229； UniProt 42–270 Author chain W； PDBConstruct 1–229； UniProt 42–270

Proteasome subunit beta

OrganismNot specified

UniProt A0A2I0BXS0

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 28	Proteasome subunit alpha type-6 × 2 （W7JVP8） Proteasome subunit alpha type-2 × 2 （A0A2I0BQ13） Proteasome subunit alpha type × 2 （W7KN95） Proteasome subunit alpha type × 2 （A0A2I0BS43） Proteasome subunit alpha type × 2 （A0A2I0BP34） Proteasome subunit alpha type-1 × 2 （W7K5W7） Proteasome subunit alpha type-3 × 2 （W7K040） Proteasome subunit beta type-6 × 2 （W7JUG8） Proteasome subunit beta × 2 （W7K1J4） Proteasome subunit beta × 2 （W7JKG5） Proteasome subunit beta × 2 （W7K6A8） Proteasome subunit beta × 2 （A0A2I0BU46） Proteasome subunit beta × 2 （W7K6I2） ;(7S,10S,13S)-N-cyclopentyl-10-[2-(morpholin-4-yl)ethyl]-9,12-dioxo-13-(2-oxopyrrolidin-1-yl)-2-oxa-8,11-diazabicyclo[13.3.1]nonadeca-1(19),15,17-triene-7-carboxamide ; × 6 water × 28	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	A0A2I0BXS0_PLAFO
Isoform	—
PDB entities	10
Chains and sequence ranges	Author chain J； PDBConstruct 1–218； UniProt 1–218 Author chain X； PDBConstruct 1–218； UniProt 1–218

Proteasome subunit beta

OrganismNot specified

UniProt W7JKG5

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 28	Proteasome subunit alpha type-6 × 2 （W7JVP8） Proteasome subunit alpha type-2 × 2 （A0A2I0BQ13） Proteasome subunit alpha type × 2 （W7KN95） Proteasome subunit alpha type × 2 （A0A2I0BS43） Proteasome subunit alpha type × 2 （A0A2I0BP34） Proteasome subunit alpha type-1 × 2 （W7K5W7） Proteasome subunit alpha type-3 × 2 （W7K040） Proteasome subunit beta type-6 × 2 （W7JUG8） Proteasome subunit beta × 2 （W7K1J4） Proteasome subunit beta × 2 （A0A2I0BXS0） Proteasome subunit beta × 2 （W7K6A8） Proteasome subunit beta × 2 （A0A2I0BU46） Proteasome subunit beta × 2 （W7K6I2） ;(7S,10S,13S)-N-cyclopentyl-10-[2-(morpholin-4-yl)ethyl]-9,12-dioxo-13-(2-oxopyrrolidin-1-yl)-2-oxa-8,11-diazabicyclo[13.3.1]nonadeca-1(19),15,17-triene-7-carboxamide ; × 6 water × 28	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	W7JKG5_PLAFO
Isoform	—
PDB entities	11
Chains and sequence ranges	Author chain K； PDBConstruct 1–195； UniProt 1–195 Author chain Y； PDBConstruct 1–195； UniProt 1–195

Proteasome subunit beta

OrganismNot specified

UniProt W7K6A8

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 28	Proteasome subunit alpha type-6 × 2 （W7JVP8） Proteasome subunit alpha type-2 × 2 （A0A2I0BQ13） Proteasome subunit alpha type × 2 （W7KN95） Proteasome subunit alpha type × 2 （A0A2I0BS43） Proteasome subunit alpha type × 2 （A0A2I0BP34） Proteasome subunit alpha type-1 × 2 （W7K5W7） Proteasome subunit alpha type-3 × 2 （W7K040） Proteasome subunit beta type-6 × 2 （W7JUG8） Proteasome subunit beta × 2 （W7K1J4） Proteasome subunit beta × 2 （A0A2I0BXS0） Proteasome subunit beta × 2 （W7JKG5） Proteasome subunit beta × 2 （A0A2I0BU46） Proteasome subunit beta × 2 （W7K6I2） ;(7S,10S,13S)-N-cyclopentyl-10-[2-(morpholin-4-yl)ethyl]-9,12-dioxo-13-(2-oxopyrrolidin-1-yl)-2-oxa-8,11-diazabicyclo[13.3.1]nonadeca-1(19),15,17-triene-7-carboxamide ; × 6 water × 28	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	W7K6A8_PLAFO
Isoform	—
PDB entities	12
Chains and sequence ranges	Author chain L； PDBConstruct 1–211； UniProt 61–271 Author chain Z； PDBConstruct 1–211； UniProt 61–271

Proteasome subunit beta

OrganismNot specified

UniProt A0A2I0BU46

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 28	Proteasome subunit alpha type-6 × 2 （W7JVP8） Proteasome subunit alpha type-2 × 2 （A0A2I0BQ13） Proteasome subunit alpha type × 2 （W7KN95） Proteasome subunit alpha type × 2 （A0A2I0BS43） Proteasome subunit alpha type × 2 （A0A2I0BP34） Proteasome subunit alpha type-1 × 2 （W7K5W7） Proteasome subunit alpha type-3 × 2 （W7K040） Proteasome subunit beta type-6 × 2 （W7JUG8） Proteasome subunit beta × 2 （W7K1J4） Proteasome subunit beta × 2 （A0A2I0BXS0） Proteasome subunit beta × 2 （W7JKG5） Proteasome subunit beta × 2 （W7K6A8） Proteasome subunit beta × 2 （W7K6I2） ;(7S,10S,13S)-N-cyclopentyl-10-[2-(morpholin-4-yl)ethyl]-9,12-dioxo-13-(2-oxopyrrolidin-1-yl)-2-oxa-8,11-diazabicyclo[13.3.1]nonadeca-1(19),15,17-triene-7-carboxamide ; × 6 water × 28	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	A0A2I0BU46_PLAFO
Isoform	—
PDB entities	13
Chains and sequence ranges	Author chain M； PDBConstruct 1–240； UniProt 1–240 Author chain a； PDBConstruct 1–240； UniProt 1–240

Proteasome subunit beta

OrganismNot specified

UniProt W7K6I2

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 28	Proteasome subunit alpha type-6 × 2 （W7JVP8） Proteasome subunit alpha type-2 × 2 （A0A2I0BQ13） Proteasome subunit alpha type × 2 （W7KN95） Proteasome subunit alpha type × 2 （A0A2I0BS43） Proteasome subunit alpha type × 2 （A0A2I0BP34） Proteasome subunit alpha type-1 × 2 （W7K5W7） Proteasome subunit alpha type-3 × 2 （W7K040） Proteasome subunit beta type-6 × 2 （W7JUG8） Proteasome subunit beta × 2 （W7K1J4） Proteasome subunit beta × 2 （A0A2I0BXS0） Proteasome subunit beta × 2 （W7JKG5） Proteasome subunit beta × 2 （W7K6A8） Proteasome subunit beta × 2 （A0A2I0BU46） ;(7S,10S,13S)-N-cyclopentyl-10-[2-(morpholin-4-yl)ethyl]-9,12-dioxo-13-(2-oxopyrrolidin-1-yl)-2-oxa-8,11-diazabicyclo[13.3.1]nonadeca-1(19),15,17-triene-7-carboxamide ; × 6 water × 28	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	W7K6I2_PLAFO
Isoform	—
PDB entities	14
Chains and sequence ranges	Author chain N； PDBConstruct 1–265； UniProt 1–265 Author chain b； PDBConstruct 1–265； UniProt 1–265

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id	8g6e
Deposition date deposition_date	2023-02-15
Structure title title	Structure of the Plasmodium falciparum 20S proteasome complexed with inhibitor TDI-8304
Keywords keywords	proteasome, inhibitor, 20S, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR complex; HYDROLASE/HYDROLASE INHIBITOR
Experimental Method method	ELECTRON MICROSCOPY

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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

8g6e__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

8g6e__assembly_1__model_1 | I(q)

100 plotted points; both axes use logarithmic scales.

8g6e__assembly_1__model_1 | P(r) · Pending

P(r) will be calculated and displayed separately for the same assembly/model.

Rg（Guinier）	60.25 Å
Rg (electron density)	59.76 Å
Total Rg	60.03 Å
Atom count	52006
Residues	6490
Excluded volume	929780 Å³
Maximum q	0.500 Å⁻¹

Assembly	Model	Structure unit	Oligomeric description	Status	CRYSOL	Actions
1	1	`8g6e__assembly_1__model_1`	28-meric （28）	Success	4.1.3-1-20251215 (887e7ef)	View Download

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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (16)

Entity 1 Entity 1 polymer

Description description	Proteasome subunit alpha type-6
Molecular weight formula_weight	29531.7 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	A,O
Atom count atom_count	52266

MVRPSQSMYDRHLTIFSPDGNLYQIEYAIKAVKNTNITSVGVKGENCAVIISQKKMATQYISQDKLLDYNNITNIYNITDEIGCSMVGMPGDCLSMVYKARSEASEFLYSNGYNVNAETLCRNICDKIQVYTQHAYMRLHACSGMIIGIDENNKPELFKFDPSGFCAGYRACVIGNKEQESISVLERLLEKRKKKIQQETIDEDIRNTTILAIEALQTILAFDLKASEIEVAIVSTKNRNFTQISEKEIDNYLTYIAERD

Entity 2 Entity 2 polymer

Description description	Proteasome subunit alpha type-2
Molecular weight formula_weight	26556.4 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	B,P

MADGEYSFSLTTFSPTGKLVQIEYALNRVSSSSPALGIRAKNGVIIATEKKSPNELIEENSIFKIQQISEHIGIVYAGMPGDFRVLLKRARKEAIRYSLQYGSEILVKELVKIIASIVQEFTQTGGVRPFGLSLLICGVDVYGYHLYQIDPSGCYFNWMATCVGKDYQNNMSFLEKRYNKDIEIEDAIHTAILTLKESYEGVLNEKNIEIGVAYDNKPFKILTQNEIKDYLIEIE

Entity 3 Entity 3 polymer

Description description	Proteasome subunit alpha type
Molecular weight formula_weight	27977.7 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	C,Q

MARRYDSRTTTFSPEGRLYQVEYALEAINNASITIGLITKDGVILGADKVFISKLIDKANNYEKIYKIDKHIFCGVAGLNADANILINQSRLYAQRYLYNYNEVQPVSQLVVQICDIKQSYTQYGGLRPYGVSFLIGGYDTKDGYQLYHTDPSGNYSGWFATAIGTNNLTASSVLKQEWKNDMTLEEGLLLALKTLAKSTDTEIPKSEKIELAYLTNKDGEVYQKYLTEKEIEELIKLYTQKYIKE

Entity 4 Entity 4 polymer

Description description	Proteasome subunit alpha type
Molecular weight formula_weight	27263.3 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	D,R

MSYDRAITVFSPDGHLLQVEHALEAVKKGGCAVAIKSSNFAVLAVEKKNIPKLQNPKTTEKLIKLDEHNCLAFAGLNADARVLVNKTRLECQRYYLNMDEPAPVDYIAKYVAKVQQKFTHRGGVRPFGIATLIAGFKNNKEICIYQTEPSGIYAAWKAQAIGKNAKIVQEFLEKNYQENMEQKDCIFLALKAIFEVVELSSKNVEVALLTEKDLTFIEEQEINSMVELIDQERTKNNEQNE

Entity 5 Entity 5 polymer

Description description	Proteasome subunit alpha type
Molecular weight formula_weight	28417.4 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	E,S

MFSTRSEYDRGVNTFSPEGRLFQVEYALGAIKLGSTAVGICVNDGVILASERRISSTLIEKDSVEKLLSIDDHIGCAMSGLMADARTLIDYARVECNHYKFIYNENINIKSCVELISELALDFSNLSDSKRKKIMSRPFGVALLIGGVDKNGPCLWYTEPSGTNTRFSAASIGSAQEGAELLLQENYKKDMTFEQAEILALTVLRQVMEDKLSTSNVEICAIKKSDQTFYKYNTDDISRIIDVLPSPVYPTIDMTA

Entity 6 Entity 6 polymer

Description description	Proteasome subunit alpha type-1
Molecular weight formula_weight	28742.6 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	F,T

MYRNLYDTDNIIYSPEGRLYQVEYASEAIKQGTCAVAIKSKDYVVVSGLKKCISKLSFPQEKIFKIDDYIGISMSGITSDAKVLTKFMQNECLSHKFLYNENINIESLVRSVADKYQKNTQKSSKRAFGVGLMIAAYHNEPCIFETRPNGSYFEYDALSFGARSHASKTYLEKNLHLFEECSLEELILHCLKALKCSLSSESELTISNTALAVVGKNHPWQEISSLQLEEYLSKVKMDAEQEQVEENVQNEAN

Entity 7 Entity 7 polymer

Description description	Proteasome subunit alpha type-3
Molecular weight formula_weight	29324.3 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	G,U

MAGLSAGYDLSVSTFSPDGRLYQVEYIYKSINNNNTALCLECKDGIICCCINSNMDKNKMIKKNSYNRIYHVNNNIIITYSGFDGDARNIIDRARSEANTYYYNFHTNIPLHILVNRISLYIHAYTLYWHMRPFAASIIISSFNEKDKGDIYCIEPNGACYKYSGIVIGKNKEMFKTEIEKKDYKDINVRDAIEDIYKFILTSDDHMNKNNLQNLVNFSWICKESSYEFQNIHEEILTPALNKAVEYIEKLN

Entity 8 Entity 8 polymer

Description description	Proteasome subunit beta type-6
Molecular weight formula_weight	29143.9 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	H,V

TTIIGIIYDNGVMLACDSRTSSGTFISNKCSRKINRINENLYVCRSGASAHSQKIIEIIKHYCVSMKNENRKKGRFHEGETIYDETTYDEEIDIDSINYLDYNNNNDNNLVTKNKYFYEDKFNDYNPLVENVAHITKKIIYTNNNFLSCALIFGGYDKIKKQQLYAVNLNGSIIEKHDFAVSGSGSIYIQSYLQDKYKKFMTKKECFNLILNCVKYAMHNDNSSGGLIRIVNITKSFVEEFTVVNTQMNFQY

Entity 9 Entity 9 polymer

Description description	Proteasome subunit beta
Molecular weight formula_weight	25104.9 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	I,W

TTICGLVCQNAVILGADTRATEGPIVADKNCSKLHYISKNIWCAGAGVAGDLEHTTLWLQHNVELHRLNTNTQPRVSMCVSRLTQELFKYQGYKVCAIVLGGVDVNGPQLYGIHPHGSSCLLPFTALGSGSLNAMAVLEAKYRDNMTIEEGKNLVCEAICAGIFNDLGSGGNVDICVITKDSYQHIRPYKEPNMRLYHLPHPTIYPKGTTPILSEKIEYIKKFISVEDA

Entity 10 Entity 10 polymer

Description description	Proteasome subunit beta
Molecular weight formula_weight	24533.1 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	J,X

MGSIYNYNGGCVLGMSGSNCVAIACDLRLGANTFTTVSTKFSKIFKMNNNVYVGLSGLATDIQTLYEILRYRVNLYEVRQDAEMDVECFANMLSSILYSNRFSPYFVNPIVVGFKLKHYVDEEGEKKVNYEPYLTAYDLIGAKCETRDFVVNGVTSEQLFGMCESLYVKDQDENGLFETISQCLLSALDRDCISGWGAEVLVLTPEKIIKKKLKARMD

Entity 11 Entity 11 polymer

Description description	Proteasome subunit beta
Molecular weight formula_weight	22889.1 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	K,Y

MDTLIGLRGNNFVVLAADTYSINSIIKLKNDDNTKFYDIHGNKCLLLGGSIGDRLQFGEFIRKNVHLYQYQNNTDMFVKSFAFFTRKNLAYYLRRNPFEVNCLIAGYDKKDGYQLYWCDYLSNMDSVNKGAHGYGAYLVSAILDKYYHENLTVDEALDIFKLCFEELKKRFLLTQINYELRIMYDNKVETQYVTV

Entity 12 Entity 12 polymer

Description description	Proteasome subunit beta
Molecular weight formula_weight	23620.6 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	L,Z

TTTLAFKFKDGIIVAVDSRASMGSFISSQNVEKIIEINKNILGTMAGGAADCLYWEKYLGKIIKIYELRNNEKISVRAASTILSNILYQYKGYGLCCGIILSGYDHTGFNMFYVDDSGKKVEGNLFSCGSGSTYAYSILDSAYDYNLNLDQAVELARNAIYHATFRDGGSGGKVRVFHIHKNGYDKIIEGEDVFDLHYHYTNPEQKDQYVM

Entity 13 Entity 13 polymer

Description description	Proteasome subunit beta
Molecular weight formula_weight	27301.2 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	M,a

MDLILYNDNLTEKKTEKENVIEHGRGFKRWYPYIDNGGTVIGLTGKDYVILAADTRLSLSYSIYTRFCPKISKLTDKCIIGSSGMQSDIKTLHSLLQKKIQLFVLEHSHYPDIHVIARLLCVILYSRRFFPYYAFNILAGVDENNKGVLYNYDSVGSYCEATHSCVGSGSQLILPILDNRVEQKNQLIKNTNFNLGDDINFVKDAITSATERDIYTGDKTLIYVIDKMGINVNTLDLKQD

Entity 14 Entity 14 polymer

Description description	Proteasome subunit beta
Molecular weight formula_weight	30909.9 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	N,b

MTLGPVVTGTSVIAIKYKHGIMIAADRKASYGSYAKFQNVERIFKINNKTVMGFSGELADAQYLHELLTRKNINNLSEKKRKEDMYTPQHYHSYVSRVFYVRKNRIDPLFNNIIIAGINSQKYDNNDDNVLLYTNKNNDDEQNEYKNNEEYKEIHKDDLYIGFVDMHGTNFCDDYITTGYARYFALTLLRDHYKDNMTEEEARILINECLRILYFRDATSSNFIQIVKVTSKGVEYEEPYILPCVLNSADYVYPSTLLPPAGCMW

Entity 15 Entity 15 non-polymer

Description description	;(7S,10S,13S)-N-cyclopentyl-10-[2-(morpholin-4-yl)ethyl]-9,12-dioxo-13-(2-oxopyrrolidin-1-yl)-2-oxa-8,11-diazabicyclo[13.3.1]nonadeca-1(19),15,17-triene-7-carboxamide ;
Molecular weight formula_weight	597.7 kDa
Source method src_method	syn
Copy count entity_count	6

Entity 16 Entity 16 water

Description description	water
Molecular weight formula_weight	18.0 kDa
Source method src_method	nat
Copy count entity_count	218

▶

Unit-cell length a length_a	1.000 Å
Unit-cell length b length_b	1.000 Å
Unit-cell length c length_c	1.000 Å
Unit-cell angle α angle_alpha	90.00 °
Unit-cell angle β angle_beta	90.00 °
Unit-cell angle γ angle_gamma	90.00 °
Molecules per unit cell Z z_pdb	—

Space group space_group	P 1
Space-group number int_tables_number	1
Crystal system crystal_system	—

Resolution resolution	2.18 Å
Resolution测定Method resolution_method	—
颗粒数 num_particles	305581

Structure of the Plasmodium falciparum 20S proteasome complexed with inhibitor TDI-8304

1. Protein Identity and Related Structures Protein Identity & Related Structures

Proteasome subunit alpha type-6

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

Proteasome subunit alpha type-2

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

Proteasome subunit alpha type

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

Proteasome subunit alpha type

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

Proteasome subunit alpha type

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

Proteasome subunit alpha type-1

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

Proteasome subunit alpha type-3

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

Proteasome subunit beta type-6

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

Proteasome subunit beta

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

Proteasome subunit beta

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer