9y0k

Structure of Plasmodium falciparum 20S proteasome with bound J80

Method: ELECTRON MICROSCOPY D_max: 189.0 Å Quality: GOOD

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1. Protein Identity and Related Structures Protein Identity & Related Structures

Proteasome subunit alpha type-6

Plasmodium falciparum Dd2

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein heterocomplex Heteromer Protein × 28 PDB declaration: 28-meric（28） Consistent with protein copy count	Chain A； UniProt 1–260 Chain O； UniProt 1–260	Not recorded	Proteasome subunit alpha type-2 × 2 （C6KST3） Proteasome subunit alpha type-3 × 2 （Q8IDG3） Proteasome subunit alpha type-4 × 2 （Q8IDG2） Proteasome subunit alpha type-5 × 2 （A0A0L7LVZ5） Proteasome subunit alpha type-1 × 2 （Q8IK90） Proteasome subunit alpha type-3 × 2 （O77396） Proteasome endopeptidase complex × 2 （A0A0L7M1M6） Proteasome subunit beta-2 × 2 （Q8I6T3） Proteasome subunit beta-3 × 2 （Q8I261） Proteasome subunit beta-4 × 2 （Q8IKC9） Proteasome subunit beta × 2 （A0A024W8G7） Proteasome subunit beta × 2 （A0A2I0BU46） Proteasome subunit beta × 2 A1CRO N,N-diethyl-N~2~-hexanoyl-D-asparaginyl-N-{(1S)-2-(2,4-difluorophenyl)-1-[(2S,3S,5S,6S)-5-formyl-2-hydroxy-3-(hydroxymethyl)-3,6-dimethylmorpholin-2-yl]ethyl}-4-fluoro-L-phenylalaninamide × 2	ELECTRON MICROSCOPY cryo-EM buffer：pH 7.5 cryo-EM vitrification conditions：Cryogen ETHANE	Resolution 3.00 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB	Difference from Current Entry 9Y0K	Assembly / Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Non-polymers	Method and Experimental Conditions	Structure Quality
5FMG Structure and function based design of Plasmodium-selective proteasome inhibitors Deposited 2015-11-04	Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric	Chain A 1–260（260 aa） Chain O 1–260（260 aa）	Not recorded	7F1 (2S)-N-[(E,2S)-1-(1H-indol-3-yl)-4-methylsulfonyl-but-3-en-2-yl]-2-[[(2S)-3-(1H-indol-3-yl)-2-(2-morpholin-4-ylethanoylamino)propanoyl]amino]-4-methyl-pentanamide × 2	ELECTRON MICROSCOPY cryo-EM buffer 50MM TRIS HCL, 5MM MGCL2, 1MM DITHIOTREITOL；pH 7.5；50MM TRIS HCL, 5MM MGCL2, 1MM DITHIOTREITOL cryo-EM vitrification conditions Cryogen ETHANE；VITRIFICATION 1 -- CRYOGEN- ETHANE, HUMIDITY- 95, INSTRUMENT- FEI VITROBOT MARK III, METHOD- BLOT 2.5 SECONDS BEFORE PLUNGING,	Resolution 3.60 Å
6MUV The structure of the Plasmodium falciparum 20S proteasome in complex with two PA28 activators Deposited 2018-10-23	Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 42 PDB declaration: 42-meric	Chain A 1–260（260 aa） Chain O 1–260（260 aa）	Not recorded	No recorded non-water small molecule	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE；wait time 0sec blot time 2sec blot force -1	Resolution 3.80 Å
6MUW The structure of the Plasmodium falciparum 20S proteasome. Deposited 2018-10-23	Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric	Chain A 1–260（260 aa） Chain O 1–260（260 aa）	Not recorded	No recorded non-water small molecule	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE；wait time 0sec blot time 2sec blot force -1	Resolution 3.60 Å
6MUX The structure of the Plasmodium falciparum 20S proteasome in complex with one PA28 activator Deposited 2018-10-23	Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 35 PDB declaration: 35-meric	Chain A 1–260（260 aa） Chain O 1–260（260 aa）	Not recorded	No recorded non-water small molecule	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE；wait time 0sec blot time 2sec blot force -1	Resolution 3.90 Å
7LXT Structure of Plasmodium falciparum 20S proteasome with bound bortezomib Deposited 2021-03-05	Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric	Chain A 1–260（260 aa） Chain O 1–260（260 aa）	Not recorded	BO2 N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE × 6	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.40 Å
7LXU Structure of Plasmodium falciparum 20S proteasome with bound MPI-5 Deposited 2021-03-05	Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric	Chain A 1–260（260 aa） Chain O 1–260（260 aa）	Not recorded	YHD N-[(1R)-2-([1,1'-biphenyl]-4-yl)-1-boronoethyl]-1-methyl-L-prolinamide × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.10 Å
8G6F Structure of the Plasmodium falciparum 20S proteasome beta-6 A117D mutant complexed with inhibitor WLW-vs Deposited 2023-02-15	Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric	Chain A 1–260（260 aa） Chain O 1–260（260 aa）	Not recorded	7F1 (2S)-N-[(E,2S)-1-(1H-indol-3-yl)-4-methylsulfonyl-but-3-en-2-yl]-2-[[(2S)-3-(1H-indol-3-yl)-2-(2-morpholin-4-ylethanoylamino)propanoyl]amino]-4-methyl-pentanamide × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.58 Å
8W2F Plasmodium falciparum 20S proteasome bound to an inhibitor Deposited 2024-02-20	Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric	Chain A 1–260（260 aa） Chain O 1–260（260 aa）	Not recorded	A1AE6 (3S)-1-[(2-fluoroethoxy)acetyl]-N-{[(4P)-4-(6-methylpyridin-3-yl)-1,3-thiazol-2-yl]methyl}piperidine-3-carboxamide × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.6 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.10 Å
9O3E Plasmodium falciparum 20S proteasome bound to inhibitor 159 Deposited 2025-04-07	Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric	Chain A 1–260（260 aa） Chain O 1–260（260 aa）	Not recorded	A1B74 (3S)-N~3~-{(1S)-1-[4-(4-cyanophenyl)-1,3-thiazol-2-yl]ethyl}-N~1~-ethoxypiperidine-1,3-dicarboxamide × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.6 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.79 Å
9O3F Plasmodium falciparum 20S proteasome bound to inhibitor 296 Deposited 2025-04-07	Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric	Chain A 1–260（260 aa） Chain O 1–260（260 aa）	Not recorded	A1B73 (3S)-1-({[(3S)-piperidin-3-yl]oxy}acetyl)-N-({4-[4-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl}methyl)piperidine-3-carboxamide × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.6 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.28 Å
9Y0L Incorrectly assembled half-Pf20S Deposited 2025-08-28	Different construct Different mutation/modification Different oligomeric state Different ligand/ion	Assembly 1 Protein heterocomplex Heteromer；Protein × 15 PDB declaration: pentadecameric	Chain A 1–260（260 aa）	Not recorded	No recorded non-water small molecule	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.00 Å
9Y1O The structure of the Plasmodium falciparum 20S proteasome Deposited 2025-08-29	Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric	Chain A 1–260（260 aa） Chain O 1–260（260 aa）	Not recorded	No recorded non-water small molecule	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.10 Å
9YUY Structure of the Plasmodium falciparum 20S proteasome in complex with a beta5-selective covalent syringolin analogue inhibitor. Deposited 2025-10-23	Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric	Chain A 1–260（260 aa） Chain O 1–260（260 aa）	Not recorded	A1CY6 methyl N-{[(2R)-1-({(5R,8R)-5-[(3-fluorophenyl)methyl]-2,7-dioxo-1,6-diazacyclododecan-8-yl}amino)-1-oxo-3-phenylpropan-2-yl]carbamoyl}-L-valinate × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.70 Å

13 other PDB entries and 13 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence

UniProt name	Q8IAR3_PLAF7
Isoform	—
PDB entities	1
Chains and sequence ranges	Author chain A； PDBConstruct 1–260； UniProt 1–260 Author chain O； PDBConstruct 1–260； UniProt 1–260

Proteasome subunit alpha type-2

Plasmodium falciparum Dd2

UniProt C6KST3

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein heterocomplex Heteromer Protein × 28 PDB declaration: 28-meric（28） Consistent with protein copy count	Chain B； UniProt 1–235 Chain P； UniProt 1–235	Not recorded	Proteasome subunit alpha type-6 × 2 （Q8IAR3） Proteasome subunit alpha type-3 × 2 （Q8IDG3） Proteasome subunit alpha type-4 × 2 （Q8IDG2） Proteasome subunit alpha type-5 × 2 （A0A0L7LVZ5） Proteasome subunit alpha type-1 × 2 （Q8IK90） Proteasome subunit alpha type-3 × 2 （O77396） Proteasome endopeptidase complex × 2 （A0A0L7M1M6） Proteasome subunit beta-2 × 2 （Q8I6T3） Proteasome subunit beta-3 × 2 （Q8I261） Proteasome subunit beta-4 × 2 （Q8IKC9） Proteasome subunit beta × 2 （A0A024W8G7） Proteasome subunit beta × 2 （A0A2I0BU46） Proteasome subunit beta × 2 A1CRO N,N-diethyl-N~2~-hexanoyl-D-asparaginyl-N-{(1S)-2-(2,4-difluorophenyl)-1-[(2S,3S,5S,6S)-5-formyl-2-hydroxy-3-(hydroxymethyl)-3,6-dimethylmorpholin-2-yl]ethyl}-4-fluoro-L-phenylalaninamide × 2	ELECTRON MICROSCOPY cryo-EM buffer：pH 7.5 cryo-EM vitrification conditions：Cryogen ETHANE	Resolution 3.00 Å

Other States of the Same Protein in the Database

Other PDB	Difference from Current Entry 9Y0K	Assembly / Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Non-polymers	Method and Experimental Conditions	Structure Quality
5FMG Structure and function based design of Plasmodium-selective proteasome inhibitors Deposited 2015-11-04	Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric	Chain B 1–235（235 aa） Chain P 1–235（235 aa）	Not recorded	7F1 (2S)-N-[(E,2S)-1-(1H-indol-3-yl)-4-methylsulfonyl-but-3-en-2-yl]-2-[[(2S)-3-(1H-indol-3-yl)-2-(2-morpholin-4-ylethanoylamino)propanoyl]amino]-4-methyl-pentanamide × 2	ELECTRON MICROSCOPY cryo-EM buffer 50MM TRIS HCL, 5MM MGCL2, 1MM DITHIOTREITOL；pH 7.5；50MM TRIS HCL, 5MM MGCL2, 1MM DITHIOTREITOL cryo-EM vitrification conditions Cryogen ETHANE；VITRIFICATION 1 -- CRYOGEN- ETHANE, HUMIDITY- 95, INSTRUMENT- FEI VITROBOT MARK III, METHOD- BLOT 2.5 SECONDS BEFORE PLUNGING,	Resolution 3.60 Å
6MUV The structure of the Plasmodium falciparum 20S proteasome in complex with two PA28 activators Deposited 2018-10-23	Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 42 PDB declaration: 42-meric	Chain B 1–235（235 aa） Chain P 1–235（235 aa）	Not recorded	No recorded non-water small molecule	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE；wait time 0sec blot time 2sec blot force -1	Resolution 3.80 Å
6MUW The structure of the Plasmodium falciparum 20S proteasome. Deposited 2018-10-23	Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric	Chain B 1–235（235 aa） Chain P 1–235（235 aa）	Not recorded	No recorded non-water small molecule	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE；wait time 0sec blot time 2sec blot force -1	Resolution 3.60 Å
6MUX The structure of the Plasmodium falciparum 20S proteasome in complex with one PA28 activator Deposited 2018-10-23	Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 35 PDB declaration: 35-meric	Chain B 1–235（235 aa） Chain P 1–235（235 aa）	Not recorded	No recorded non-water small molecule	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE；wait time 0sec blot time 2sec blot force -1	Resolution 3.90 Å
7LXT Structure of Plasmodium falciparum 20S proteasome with bound bortezomib Deposited 2021-03-05	Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric	Chain B 1–235（235 aa） Chain P 1–235（235 aa）	Not recorded	BO2 N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE × 6	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.40 Å
7LXU Structure of Plasmodium falciparum 20S proteasome with bound MPI-5 Deposited 2021-03-05	Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric	Chain B 1–235（235 aa） Chain P 1–235（235 aa）	Not recorded	YHD N-[(1R)-2-([1,1'-biphenyl]-4-yl)-1-boronoethyl]-1-methyl-L-prolinamide × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.10 Å
8G6F Structure of the Plasmodium falciparum 20S proteasome beta-6 A117D mutant complexed with inhibitor WLW-vs Deposited 2023-02-15	Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric	Chain B 1–235（235 aa） Chain P 1–235（235 aa）	Not recorded	7F1 (2S)-N-[(E,2S)-1-(1H-indol-3-yl)-4-methylsulfonyl-but-3-en-2-yl]-2-[[(2S)-3-(1H-indol-3-yl)-2-(2-morpholin-4-ylethanoylamino)propanoyl]amino]-4-methyl-pentanamide × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.58 Å
8W2F Plasmodium falciparum 20S proteasome bound to an inhibitor Deposited 2024-02-20	Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric	Chain B 1–235（235 aa） Chain P 1–235（235 aa）	Not recorded	A1AE6 (3S)-1-[(2-fluoroethoxy)acetyl]-N-{[(4P)-4-(6-methylpyridin-3-yl)-1,3-thiazol-2-yl]methyl}piperidine-3-carboxamide × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.6 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.10 Å
9O3E Plasmodium falciparum 20S proteasome bound to inhibitor 159 Deposited 2025-04-07	Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric	Chain B 1–235（235 aa） Chain P 1–235（235 aa）	Not recorded	A1B74 (3S)-N~3~-{(1S)-1-[4-(4-cyanophenyl)-1,3-thiazol-2-yl]ethyl}-N~1~-ethoxypiperidine-1,3-dicarboxamide × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.6 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.79 Å
9O3F Plasmodium falciparum 20S proteasome bound to inhibitor 296 Deposited 2025-04-07	Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric	Chain B 1–235（235 aa） Chain P 1–235（235 aa）	Not recorded	A1B73 (3S)-1-({[(3S)-piperidin-3-yl]oxy}acetyl)-N-({4-[4-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl}methyl)piperidine-3-carboxamide × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.6 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.28 Å
9Y0L Incorrectly assembled half-Pf20S Deposited 2025-08-28	Different construct Different mutation/modification Different oligomeric state Different ligand/ion	Assembly 1 Protein heterocomplex Heteromer；Protein × 15 PDB declaration: pentadecameric	Chain B 1–235（235 aa）	Not recorded	No recorded non-water small molecule	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.00 Å
9Y1O The structure of the Plasmodium falciparum 20S proteasome Deposited 2025-08-29	Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric	Chain B 1–235（235 aa） Chain P 1–235（235 aa）	Not recorded	No recorded non-water small molecule	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.10 Å
9YUY Structure of the Plasmodium falciparum 20S proteasome in complex with a beta5-selective covalent syringolin analogue inhibitor. Deposited 2025-10-23	Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric	Chain B 1–235（235 aa） Chain P 1–235（235 aa）	Not recorded	A1CY6 methyl N-{[(2R)-1-({(5R,8R)-5-[(3-fluorophenyl)methyl]-2,7-dioxo-1,6-diazacyclododecan-8-yl}amino)-1-oxo-3-phenylpropan-2-yl]carbamoyl}-L-valinate × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.70 Å

13 other PDB entries and 13 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence

UniProt name	C6KST3_PLAF7
Isoform	—
PDB entities	2
Chains and sequence ranges	Author chain B； PDBConstruct 1–235； UniProt 1–235 Author chain P； PDBConstruct 1–235； UniProt 1–235

Proteasome subunit alpha type-3

Plasmodium falciparum Dd2

UniProt Q8IDG3

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein heterocomplex Heteromer Protein × 28 PDB declaration: 28-meric（28） Consistent with protein copy count	Chain C； UniProt 1–246 Chain Q； UniProt 1–246	Not recorded	Proteasome subunit alpha type-6 × 2 （Q8IAR3） Proteasome subunit alpha type-2 × 2 （C6KST3） Proteasome subunit alpha type-4 × 2 （Q8IDG2） Proteasome subunit alpha type-5 × 2 （A0A0L7LVZ5） Proteasome subunit alpha type-1 × 2 （Q8IK90） Proteasome subunit alpha type-3 × 2 （O77396） Proteasome endopeptidase complex × 2 （A0A0L7M1M6） Proteasome subunit beta-2 × 2 （Q8I6T3） Proteasome subunit beta-3 × 2 （Q8I261） Proteasome subunit beta-4 × 2 （Q8IKC9） Proteasome subunit beta × 2 （A0A024W8G7） Proteasome subunit beta × 2 （A0A2I0BU46） Proteasome subunit beta × 2 A1CRO N,N-diethyl-N~2~-hexanoyl-D-asparaginyl-N-{(1S)-2-(2,4-difluorophenyl)-1-[(2S,3S,5S,6S)-5-formyl-2-hydroxy-3-(hydroxymethyl)-3,6-dimethylmorpholin-2-yl]ethyl}-4-fluoro-L-phenylalaninamide × 2	ELECTRON MICROSCOPY cryo-EM buffer：pH 7.5 cryo-EM vitrification conditions：Cryogen ETHANE	Resolution 3.00 Å

Other States of the Same Protein in the Database

Other PDB	Difference from Current Entry 9Y0K	Assembly / Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Non-polymers	Method and Experimental Conditions	Structure Quality
5FMG Structure and function based design of Plasmodium-selective proteasome inhibitors Deposited 2015-11-04	Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric	Chain C 1–246（246 aa） Chain Q 1–246（246 aa）	Not recorded	7F1 (2S)-N-[(E,2S)-1-(1H-indol-3-yl)-4-methylsulfonyl-but-3-en-2-yl]-2-[[(2S)-3-(1H-indol-3-yl)-2-(2-morpholin-4-ylethanoylamino)propanoyl]amino]-4-methyl-pentanamide × 2	ELECTRON MICROSCOPY cryo-EM buffer 50MM TRIS HCL, 5MM MGCL2, 1MM DITHIOTREITOL；pH 7.5；50MM TRIS HCL, 5MM MGCL2, 1MM DITHIOTREITOL cryo-EM vitrification conditions Cryogen ETHANE；VITRIFICATION 1 -- CRYOGEN- ETHANE, HUMIDITY- 95, INSTRUMENT- FEI VITROBOT MARK III, METHOD- BLOT 2.5 SECONDS BEFORE PLUNGING,	Resolution 3.60 Å
6MUV The structure of the Plasmodium falciparum 20S proteasome in complex with two PA28 activators Deposited 2018-10-23	Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 42 PDB declaration: 42-meric	Chain C 1–246（246 aa） Chain Q 1–246（246 aa）	Not recorded	No recorded non-water small molecule	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE；wait time 0sec blot time 2sec blot force -1	Resolution 3.80 Å
6MUW The structure of the Plasmodium falciparum 20S proteasome. Deposited 2018-10-23	Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric	Chain C 1–246（246 aa） Chain Q 1–246（246 aa）	Not recorded	No recorded non-water small molecule	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE；wait time 0sec blot time 2sec blot force -1	Resolution 3.60 Å
6MUX The structure of the Plasmodium falciparum 20S proteasome in complex with one PA28 activator Deposited 2018-10-23	Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 35 PDB declaration: 35-meric	Chain C 1–246（246 aa） Chain Q 1–246（246 aa）	Not recorded	No recorded non-water small molecule	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE；wait time 0sec blot time 2sec blot force -1	Resolution 3.90 Å
7LXT Structure of Plasmodium falciparum 20S proteasome with bound bortezomib Deposited 2021-03-05	Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric	Chain C 1–246（246 aa） Chain Q 1–246（246 aa）	Not recorded	BO2 N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE × 6	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.40 Å
7LXU Structure of Plasmodium falciparum 20S proteasome with bound MPI-5 Deposited 2021-03-05	Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric	Chain C 1–246（246 aa） Chain Q 1–246（246 aa）	Not recorded	YHD N-[(1R)-2-([1,1'-biphenyl]-4-yl)-1-boronoethyl]-1-methyl-L-prolinamide × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.10 Å
8G6F Structure of the Plasmodium falciparum 20S proteasome beta-6 A117D mutant complexed with inhibitor WLW-vs Deposited 2023-02-15	Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric	Chain C 1–246（246 aa） Chain Q 1–246（246 aa）	Not recorded	7F1 (2S)-N-[(E,2S)-1-(1H-indol-3-yl)-4-methylsulfonyl-but-3-en-2-yl]-2-[[(2S)-3-(1H-indol-3-yl)-2-(2-morpholin-4-ylethanoylamino)propanoyl]amino]-4-methyl-pentanamide × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.58 Å
8W2F Plasmodium falciparum 20S proteasome bound to an inhibitor Deposited 2024-02-20	Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric	Chain C 1–242（242 aa） Chain Q 1–242（242 aa）	Not recorded	A1AE6 (3S)-1-[(2-fluoroethoxy)acetyl]-N-{[(4P)-4-(6-methylpyridin-3-yl)-1,3-thiazol-2-yl]methyl}piperidine-3-carboxamide × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.6 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.10 Å
9O3E Plasmodium falciparum 20S proteasome bound to inhibitor 159 Deposited 2025-04-07	Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric	Chain C 1–246（246 aa） Chain Q 1–246（246 aa）	Not recorded	A1B74 (3S)-N~3~-{(1S)-1-[4-(4-cyanophenyl)-1,3-thiazol-2-yl]ethyl}-N~1~-ethoxypiperidine-1,3-dicarboxamide × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.6 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.79 Å
9O3F Plasmodium falciparum 20S proteasome bound to inhibitor 296 Deposited 2025-04-07	Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric	Chain C 1–242（242 aa） Chain Q 1–242（242 aa）	Not recorded	A1B73 (3S)-1-({[(3S)-piperidin-3-yl]oxy}acetyl)-N-({4-[4-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl}methyl)piperidine-3-carboxamide × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.6 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.28 Å
9Y0L Incorrectly assembled half-Pf20S Deposited 2025-08-28	Different construct Different mutation/modification Different oligomeric state Different ligand/ion	Assembly 1 Protein heterocomplex Heteromer；Protein × 15 PDB declaration: pentadecameric	Chain C 1–246（246 aa）	Not recorded	No recorded non-water small molecule	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.00 Å
9Y1O The structure of the Plasmodium falciparum 20S proteasome Deposited 2025-08-29	Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric	Chain C 1–246（246 aa） Chain Q 1–246（246 aa）	Not recorded	No recorded non-water small molecule	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.10 Å
9YUY Structure of the Plasmodium falciparum 20S proteasome in complex with a beta5-selective covalent syringolin analogue inhibitor. Deposited 2025-10-23	Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric	Chain C 1–246（246 aa） Chain Q 1–246（246 aa）	Not recorded	A1CY6 methyl N-{[(2R)-1-({(5R,8R)-5-[(3-fluorophenyl)methyl]-2,7-dioxo-1,6-diazacyclododecan-8-yl}amino)-1-oxo-3-phenylpropan-2-yl]carbamoyl}-L-valinate × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.70 Å

13 other PDB entries and 13 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence

UniProt name	Q8IDG3_PLAF7
Isoform	—
PDB entities	3
Chains and sequence ranges	Author chain C； PDBConstruct 1–246； UniProt 1–246 Author chain Q； PDBConstruct 1–246； UniProt 1–246

Proteasome subunit alpha type-4

Plasmodium falciparum Dd2

UniProt Q8IDG2

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein heterocomplex Heteromer Protein × 28 PDB declaration: 28-meric（28） Consistent with protein copy count	Chain D； UniProt 1–241 Chain R； UniProt 1–241	Not recorded	Proteasome subunit alpha type-6 × 2 （Q8IAR3） Proteasome subunit alpha type-2 × 2 （C6KST3） Proteasome subunit alpha type-3 × 2 （Q8IDG3） Proteasome subunit alpha type-5 × 2 （A0A0L7LVZ5） Proteasome subunit alpha type-1 × 2 （Q8IK90） Proteasome subunit alpha type-3 × 2 （O77396） Proteasome endopeptidase complex × 2 （A0A0L7M1M6） Proteasome subunit beta-2 × 2 （Q8I6T3） Proteasome subunit beta-3 × 2 （Q8I261） Proteasome subunit beta-4 × 2 （Q8IKC9） Proteasome subunit beta × 2 （A0A024W8G7） Proteasome subunit beta × 2 （A0A2I0BU46） Proteasome subunit beta × 2 A1CRO N,N-diethyl-N~2~-hexanoyl-D-asparaginyl-N-{(1S)-2-(2,4-difluorophenyl)-1-[(2S,3S,5S,6S)-5-formyl-2-hydroxy-3-(hydroxymethyl)-3,6-dimethylmorpholin-2-yl]ethyl}-4-fluoro-L-phenylalaninamide × 2	ELECTRON MICROSCOPY cryo-EM buffer：pH 7.5 cryo-EM vitrification conditions：Cryogen ETHANE	Resolution 3.00 Å

Other States of the Same Protein in the Database

Other PDB	Difference from Current Entry 9Y0K	Assembly / Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Non-polymers	Method and Experimental Conditions	Structure Quality
5FMG Structure and function based design of Plasmodium-selective proteasome inhibitors Deposited 2015-11-04	Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric	Chain D 1–241（241 aa） Chain R 1–241（241 aa）	Not recorded	7F1 (2S)-N-[(E,2S)-1-(1H-indol-3-yl)-4-methylsulfonyl-but-3-en-2-yl]-2-[[(2S)-3-(1H-indol-3-yl)-2-(2-morpholin-4-ylethanoylamino)propanoyl]amino]-4-methyl-pentanamide × 2	ELECTRON MICROSCOPY cryo-EM buffer 50MM TRIS HCL, 5MM MGCL2, 1MM DITHIOTREITOL；pH 7.5；50MM TRIS HCL, 5MM MGCL2, 1MM DITHIOTREITOL cryo-EM vitrification conditions Cryogen ETHANE；VITRIFICATION 1 -- CRYOGEN- ETHANE, HUMIDITY- 95, INSTRUMENT- FEI VITROBOT MARK III, METHOD- BLOT 2.5 SECONDS BEFORE PLUNGING,	Resolution 3.60 Å
6MUV The structure of the Plasmodium falciparum 20S proteasome in complex with two PA28 activators Deposited 2018-10-23	Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 42 PDB declaration: 42-meric	Chain D 1–241（241 aa） Chain R 1–241（241 aa）	Not recorded	No recorded non-water small molecule	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE；wait time 0sec blot time 2sec blot force -1	Resolution 3.80 Å
6MUW The structure of the Plasmodium falciparum 20S proteasome. Deposited 2018-10-23	Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric	Chain D 1–241（241 aa） Chain R 1–241（241 aa）	Not recorded	No recorded non-water small molecule	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE；wait time 0sec blot time 2sec blot force -1	Resolution 3.60 Å
6MUX The structure of the Plasmodium falciparum 20S proteasome in complex with one PA28 activator Deposited 2018-10-23	Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 35 PDB declaration: 35-meric	Chain D 1–241（241 aa） Chain R 1–241（241 aa）	Not recorded	No recorded non-water small molecule	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE；wait time 0sec blot time 2sec blot force -1	Resolution 3.90 Å
7LXT Structure of Plasmodium falciparum 20S proteasome with bound bortezomib Deposited 2021-03-05	Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric	Chain D 1–241（241 aa） Chain R 1–241（241 aa）	Not recorded	BO2 N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE × 6	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.40 Å
7LXU Structure of Plasmodium falciparum 20S proteasome with bound MPI-5 Deposited 2021-03-05	Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric	Chain D 1–241（241 aa） Chain R 1–241（241 aa）	Not recorded	YHD N-[(1R)-2-([1,1'-biphenyl]-4-yl)-1-boronoethyl]-1-methyl-L-prolinamide × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.10 Å
8G6F Structure of the Plasmodium falciparum 20S proteasome beta-6 A117D mutant complexed with inhibitor WLW-vs Deposited 2023-02-15	Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric	Chain D 1–241（241 aa） Chain R 1–241（241 aa）	Not recorded	7F1 (2S)-N-[(E,2S)-1-(1H-indol-3-yl)-4-methylsulfonyl-but-3-en-2-yl]-2-[[(2S)-3-(1H-indol-3-yl)-2-(2-morpholin-4-ylethanoylamino)propanoyl]amino]-4-methyl-pentanamide × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.58 Å
8W2F Plasmodium falciparum 20S proteasome bound to an inhibitor Deposited 2024-02-20	Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric	Chain D 1–241（241 aa） Chain R 1–241（241 aa）	Not recorded	A1AE6 (3S)-1-[(2-fluoroethoxy)acetyl]-N-{[(4P)-4-(6-methylpyridin-3-yl)-1,3-thiazol-2-yl]methyl}piperidine-3-carboxamide × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.6 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.10 Å
9O3E Plasmodium falciparum 20S proteasome bound to inhibitor 159 Deposited 2025-04-07	Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric	Chain D 1–241（241 aa） Chain R 1–241（241 aa）	Not recorded	A1B74 (3S)-N~3~-{(1S)-1-[4-(4-cyanophenyl)-1,3-thiazol-2-yl]ethyl}-N~1~-ethoxypiperidine-1,3-dicarboxamide × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.6 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.79 Å
9O3F Plasmodium falciparum 20S proteasome bound to inhibitor 296 Deposited 2025-04-07	Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric	Chain D 1–241（241 aa） Chain R 1–241（241 aa）	Not recorded	A1B73 (3S)-1-({[(3S)-piperidin-3-yl]oxy}acetyl)-N-({4-[4-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl}methyl)piperidine-3-carboxamide × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.6 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.28 Å
9Y0L Incorrectly assembled half-Pf20S Deposited 2025-08-28	Different construct Different mutation/modification Different oligomeric state Different ligand/ion	Assembly 1 Protein heterocomplex Heteromer；Protein × 15 PDB declaration: pentadecameric	Chain D 1–241（241 aa）	Not recorded	No recorded non-water small molecule	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.00 Å
9Y1O The structure of the Plasmodium falciparum 20S proteasome Deposited 2025-08-29	Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric	Chain D 1–241（241 aa） Chain R 1–241（241 aa）	Not recorded	No recorded non-water small molecule	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.10 Å
9YUY Structure of the Plasmodium falciparum 20S proteasome in complex with a beta5-selective covalent syringolin analogue inhibitor. Deposited 2025-10-23	Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric	Chain D 1–241（241 aa） Chain R 1–241（241 aa）	Not recorded	A1CY6 methyl N-{[(2R)-1-({(5R,8R)-5-[(3-fluorophenyl)methyl]-2,7-dioxo-1,6-diazacyclododecan-8-yl}amino)-1-oxo-3-phenylpropan-2-yl]carbamoyl}-L-valinate × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.70 Å

13 other PDB entries and 13 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence

UniProt name	Q8IDG2_PLAF7
Isoform	—
PDB entities	4
Chains and sequence ranges	Author chain D； PDBConstruct 1–241； UniProt 1–241 Author chain R； PDBConstruct 1–241； UniProt 1–241

Proteasome subunit alpha type-5

Plasmodium falciparum Dd2

UniProt A0A0L7LVZ5

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein heterocomplex Heteromer Protein × 28 PDB declaration: 28-meric（28） Consistent with protein copy count	Chain E； UniProt 1–256 Chain S； UniProt 1–256	Not recorded	Proteasome subunit alpha type-6 × 2 （Q8IAR3） Proteasome subunit alpha type-2 × 2 （C6KST3） Proteasome subunit alpha type-3 × 2 （Q8IDG3） Proteasome subunit alpha type-4 × 2 （Q8IDG2） Proteasome subunit alpha type-1 × 2 （Q8IK90） Proteasome subunit alpha type-3 × 2 （O77396） Proteasome endopeptidase complex × 2 （A0A0L7M1M6） Proteasome subunit beta-2 × 2 （Q8I6T3） Proteasome subunit beta-3 × 2 （Q8I261） Proteasome subunit beta-4 × 2 （Q8IKC9） Proteasome subunit beta × 2 （A0A024W8G7） Proteasome subunit beta × 2 （A0A2I0BU46） Proteasome subunit beta × 2 A1CRO N,N-diethyl-N~2~-hexanoyl-D-asparaginyl-N-{(1S)-2-(2,4-difluorophenyl)-1-[(2S,3S,5S,6S)-5-formyl-2-hydroxy-3-(hydroxymethyl)-3,6-dimethylmorpholin-2-yl]ethyl}-4-fluoro-L-phenylalaninamide × 2	ELECTRON MICROSCOPY cryo-EM buffer：pH 7.5 cryo-EM vitrification conditions：Cryogen ETHANE	Resolution 3.00 Å

Other States of the Same Protein in the Database

Other PDB	Difference from Current Entry 9Y0K	Assembly / Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Non-polymers	Method and Experimental Conditions	Structure Quality
8G6F Structure of the Plasmodium falciparum 20S proteasome beta-6 A117D mutant complexed with inhibitor WLW-vs Deposited 2023-02-15	Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric	Chain E 1–256（256 aa） Chain S 1–256（256 aa）	Not recorded	7F1 (2S)-N-[(E,2S)-1-(1H-indol-3-yl)-4-methylsulfonyl-but-3-en-2-yl]-2-[[(2S)-3-(1H-indol-3-yl)-2-(2-morpholin-4-ylethanoylamino)propanoyl]amino]-4-methyl-pentanamide × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.58 Å
9Y0L Incorrectly assembled half-Pf20S Deposited 2025-08-28	Different construct Different mutation/modification Different oligomeric state Different ligand/ion	Assembly 1 Protein heterocomplex Heteromer；Protein × 15 PDB declaration: pentadecameric	Chain E 1–256（256 aa）	Not recorded	No recorded non-water small molecule	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.00 Å
9Y1O The structure of the Plasmodium falciparum 20S proteasome Deposited 2025-08-29	Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric	Chain E 1–256（256 aa） Chain S 1–256（256 aa）	Not recorded	No recorded non-water small molecule	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.10 Å

3 other PDB entries and 3 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence

UniProt name	A0A0L7LVZ5_PLAF4
Isoform	—
PDB entities	5
Chains and sequence ranges	Author chain E； PDBConstruct 1–256； UniProt 1–256 Author chain S； PDBConstruct 1–256； UniProt 1–256

Proteasome subunit alpha type-1

Plasmodium falciparum Dd2

UniProt Q8IK90

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein heterocomplex Heteromer Protein × 28 PDB declaration: 28-meric（28） Consistent with protein copy count	Chain F； UniProt 1–254 Chain T； UniProt 1–254	Not recorded	Proteasome subunit alpha type-6 × 2 （Q8IAR3） Proteasome subunit alpha type-2 × 2 （C6KST3） Proteasome subunit alpha type-3 × 2 （Q8IDG3） Proteasome subunit alpha type-4 × 2 （Q8IDG2） Proteasome subunit alpha type-5 × 2 （A0A0L7LVZ5） Proteasome subunit alpha type-3 × 2 （O77396） Proteasome endopeptidase complex × 2 （A0A0L7M1M6） Proteasome subunit beta-2 × 2 （Q8I6T3） Proteasome subunit beta-3 × 2 （Q8I261） Proteasome subunit beta-4 × 2 （Q8IKC9） Proteasome subunit beta × 2 （A0A024W8G7） Proteasome subunit beta × 2 （A0A2I0BU46） Proteasome subunit beta × 2 A1CRO N,N-diethyl-N~2~-hexanoyl-D-asparaginyl-N-{(1S)-2-(2,4-difluorophenyl)-1-[(2S,3S,5S,6S)-5-formyl-2-hydroxy-3-(hydroxymethyl)-3,6-dimethylmorpholin-2-yl]ethyl}-4-fluoro-L-phenylalaninamide × 2	ELECTRON MICROSCOPY cryo-EM buffer：pH 7.5 cryo-EM vitrification conditions：Cryogen ETHANE	Resolution 3.00 Å

Other States of the Same Protein in the Database

Other PDB	Difference from Current Entry 9Y0K	Assembly / Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Non-polymers	Method and Experimental Conditions	Structure Quality
5FMG Structure and function based design of Plasmodium-selective proteasome inhibitors Deposited 2015-11-04	Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric	Chain F 1–254（254 aa） Chain T 1–254（254 aa）	Not recorded	7F1 (2S)-N-[(E,2S)-1-(1H-indol-3-yl)-4-methylsulfonyl-but-3-en-2-yl]-2-[[(2S)-3-(1H-indol-3-yl)-2-(2-morpholin-4-ylethanoylamino)propanoyl]amino]-4-methyl-pentanamide × 2	ELECTRON MICROSCOPY cryo-EM buffer 50MM TRIS HCL, 5MM MGCL2, 1MM DITHIOTREITOL；pH 7.5；50MM TRIS HCL, 5MM MGCL2, 1MM DITHIOTREITOL cryo-EM vitrification conditions Cryogen ETHANE；VITRIFICATION 1 -- CRYOGEN- ETHANE, HUMIDITY- 95, INSTRUMENT- FEI VITROBOT MARK III, METHOD- BLOT 2.5 SECONDS BEFORE PLUNGING,	Resolution 3.60 Å
6MUV The structure of the Plasmodium falciparum 20S proteasome in complex with two PA28 activators Deposited 2018-10-23	Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 42 PDB declaration: 42-meric	Chain F 1–254（254 aa） Chain T 1–254（254 aa）	Not recorded	No recorded non-water small molecule	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE；wait time 0sec blot time 2sec blot force -1	Resolution 3.80 Å
6MUW The structure of the Plasmodium falciparum 20S proteasome. Deposited 2018-10-23	Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric	Chain F 1–254（254 aa） Chain T 1–254（254 aa）	Not recorded	No recorded non-water small molecule	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE；wait time 0sec blot time 2sec blot force -1	Resolution 3.60 Å
6MUX The structure of the Plasmodium falciparum 20S proteasome in complex with one PA28 activator Deposited 2018-10-23	Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 35 PDB declaration: 35-meric	Chain F 1–254（254 aa） Chain T 1–254（254 aa）	Not recorded	No recorded non-water small molecule	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE；wait time 0sec blot time 2sec blot force -1	Resolution 3.90 Å
7LXT Structure of Plasmodium falciparum 20S proteasome with bound bortezomib Deposited 2021-03-05	Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric	Chain F 1–254（254 aa） Chain T 1–254（254 aa）	Not recorded	BO2 N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE × 6	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.40 Å
7LXU Structure of Plasmodium falciparum 20S proteasome with bound MPI-5 Deposited 2021-03-05	Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric	Chain F 1–254（254 aa） Chain T 1–254（254 aa）	Not recorded	YHD N-[(1R)-2-([1,1'-biphenyl]-4-yl)-1-boronoethyl]-1-methyl-L-prolinamide × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.10 Å
8G6F Structure of the Plasmodium falciparum 20S proteasome beta-6 A117D mutant complexed with inhibitor WLW-vs Deposited 2023-02-15	Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric	Chain F 1–254（254 aa） Chain T 1–254（254 aa）	Not recorded	7F1 (2S)-N-[(E,2S)-1-(1H-indol-3-yl)-4-methylsulfonyl-but-3-en-2-yl]-2-[[(2S)-3-(1H-indol-3-yl)-2-(2-morpholin-4-ylethanoylamino)propanoyl]amino]-4-methyl-pentanamide × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.58 Å
8W2F Plasmodium falciparum 20S proteasome bound to an inhibitor Deposited 2024-02-20	Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric	Chain F 1–254（254 aa） Chain T 1–254（254 aa）	Not recorded	A1AE6 (3S)-1-[(2-fluoroethoxy)acetyl]-N-{[(4P)-4-(6-methylpyridin-3-yl)-1,3-thiazol-2-yl]methyl}piperidine-3-carboxamide × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.6 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.10 Å
9O3E Plasmodium falciparum 20S proteasome bound to inhibitor 159 Deposited 2025-04-07	Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric	Chain F 1–254（254 aa） Chain T 1–254（254 aa）	Not recorded	A1B74 (3S)-N~3~-{(1S)-1-[4-(4-cyanophenyl)-1,3-thiazol-2-yl]ethyl}-N~1~-ethoxypiperidine-1,3-dicarboxamide × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.6 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.79 Å
9O3F Plasmodium falciparum 20S proteasome bound to inhibitor 296 Deposited 2025-04-07	Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric	Chain F 1–254（254 aa） Chain T 1–254（254 aa）	Not recorded	A1B73 (3S)-1-({[(3S)-piperidin-3-yl]oxy}acetyl)-N-({4-[4-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl}methyl)piperidine-3-carboxamide × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.6 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.28 Å
9Y0L Incorrectly assembled half-Pf20S Deposited 2025-08-28	Different construct Different mutation/modification Different oligomeric state Different ligand/ion	Assembly 1 Protein heterocomplex Heteromer；Protein × 15 PDB declaration: pentadecameric	Chain F 1–254（254 aa）	Not recorded	No recorded non-water small molecule	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.00 Å
9Y1O The structure of the Plasmodium falciparum 20S proteasome Deposited 2025-08-29	Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric	Chain F 1–254（254 aa） Chain T 1–254（254 aa）	Not recorded	No recorded non-water small molecule	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.10 Å
9YUY Structure of the Plasmodium falciparum 20S proteasome in complex with a beta5-selective covalent syringolin analogue inhibitor. Deposited 2025-10-23	Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric	Chain F 1–254（254 aa） Chain T 1–254（254 aa）	Not recorded	A1CY6 methyl N-{[(2R)-1-({(5R,8R)-5-[(3-fluorophenyl)methyl]-2,7-dioxo-1,6-diazacyclododecan-8-yl}amino)-1-oxo-3-phenylpropan-2-yl]carbamoyl}-L-valinate × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.70 Å

13 other PDB entries and 13 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence

UniProt name	Q8IK90_PLAF7
Isoform	—
PDB entities	6
Chains and sequence ranges	Author chain F； PDBConstruct 1–254； UniProt 1–254 Author chain T； PDBConstruct 1–254； UniProt 1–254

Proteasome subunit alpha type-3

Plasmodium falciparum Dd2

UniProt O77396

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein heterocomplex Heteromer Protein × 28 PDB declaration: 28-meric（28） Consistent with protein copy count	Chain G； UniProt 1–252 Chain U； UniProt 1–252	Not recorded	Proteasome subunit alpha type-6 × 2 （Q8IAR3） Proteasome subunit alpha type-2 × 2 （C6KST3） Proteasome subunit alpha type-3 × 2 （Q8IDG3） Proteasome subunit alpha type-4 × 2 （Q8IDG2） Proteasome subunit alpha type-5 × 2 （A0A0L7LVZ5） Proteasome subunit alpha type-1 × 2 （Q8IK90） Proteasome endopeptidase complex × 2 （A0A0L7M1M6） Proteasome subunit beta-2 × 2 （Q8I6T3） Proteasome subunit beta-3 × 2 （Q8I261） Proteasome subunit beta-4 × 2 （Q8IKC9） Proteasome subunit beta × 2 （A0A024W8G7） Proteasome subunit beta × 2 （A0A2I0BU46） Proteasome subunit beta × 2 A1CRO N,N-diethyl-N~2~-hexanoyl-D-asparaginyl-N-{(1S)-2-(2,4-difluorophenyl)-1-[(2S,3S,5S,6S)-5-formyl-2-hydroxy-3-(hydroxymethyl)-3,6-dimethylmorpholin-2-yl]ethyl}-4-fluoro-L-phenylalaninamide × 2	ELECTRON MICROSCOPY cryo-EM buffer：pH 7.5 cryo-EM vitrification conditions：Cryogen ETHANE	Resolution 3.00 Å

Other States of the Same Protein in the Database

Other PDB	Difference from Current Entry 9Y0K	Assembly / Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Non-polymers	Method and Experimental Conditions	Structure Quality
5FMG Structure and function based design of Plasmodium-selective proteasome inhibitors Deposited 2015-11-04	Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric	Chain G 1–252（252 aa） Chain U 1–252（252 aa）	Not recorded	7F1 (2S)-N-[(E,2S)-1-(1H-indol-3-yl)-4-methylsulfonyl-but-3-en-2-yl]-2-[[(2S)-3-(1H-indol-3-yl)-2-(2-morpholin-4-ylethanoylamino)propanoyl]amino]-4-methyl-pentanamide × 2	ELECTRON MICROSCOPY cryo-EM buffer 50MM TRIS HCL, 5MM MGCL2, 1MM DITHIOTREITOL；pH 7.5；50MM TRIS HCL, 5MM MGCL2, 1MM DITHIOTREITOL cryo-EM vitrification conditions Cryogen ETHANE；VITRIFICATION 1 -- CRYOGEN- ETHANE, HUMIDITY- 95, INSTRUMENT- FEI VITROBOT MARK III, METHOD- BLOT 2.5 SECONDS BEFORE PLUNGING,	Resolution 3.60 Å
6MUV The structure of the Plasmodium falciparum 20S proteasome in complex with two PA28 activators Deposited 2018-10-23	Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 42 PDB declaration: 42-meric	Chain G 1–252（252 aa） Chain U 1–252（252 aa）	Not recorded	No recorded non-water small molecule	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE；wait time 0sec blot time 2sec blot force -1	Resolution 3.80 Å
6MUW The structure of the Plasmodium falciparum 20S proteasome. Deposited 2018-10-23	Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric	Chain G 1–252（252 aa） Chain U 1–252（252 aa）	Not recorded	No recorded non-water small molecule	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE；wait time 0sec blot time 2sec blot force -1	Resolution 3.60 Å
6MUX The structure of the Plasmodium falciparum 20S proteasome in complex with one PA28 activator Deposited 2018-10-23	Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 35 PDB declaration: 35-meric	Chain G 1–252（252 aa） Chain U 1–252（252 aa）	Not recorded	No recorded non-water small molecule	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE；wait time 0sec blot time 2sec blot force -1	Resolution 3.90 Å
7LXT Structure of Plasmodium falciparum 20S proteasome with bound bortezomib Deposited 2021-03-05	Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric	Chain G 1–252（252 aa） Chain U 1–252（252 aa）	Not recorded	BO2 N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE × 6	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.40 Å
7LXU Structure of Plasmodium falciparum 20S proteasome with bound MPI-5 Deposited 2021-03-05	Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric	Chain G 1–252（252 aa） Chain U 1–252（252 aa）	Not recorded	YHD N-[(1R)-2-([1,1'-biphenyl]-4-yl)-1-boronoethyl]-1-methyl-L-prolinamide × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.10 Å
8G6F Structure of the Plasmodium falciparum 20S proteasome beta-6 A117D mutant complexed with inhibitor WLW-vs Deposited 2023-02-15	Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric	Chain G 1–252（252 aa） Chain U 1–252（252 aa）	Not recorded	7F1 (2S)-N-[(E,2S)-1-(1H-indol-3-yl)-4-methylsulfonyl-but-3-en-2-yl]-2-[[(2S)-3-(1H-indol-3-yl)-2-(2-morpholin-4-ylethanoylamino)propanoyl]amino]-4-methyl-pentanamide × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.58 Å
8W2F Plasmodium falciparum 20S proteasome bound to an inhibitor Deposited 2024-02-20	Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric	Chain G 1–252（252 aa） Chain U 1–252（252 aa）	Not recorded	A1AE6 (3S)-1-[(2-fluoroethoxy)acetyl]-N-{[(4P)-4-(6-methylpyridin-3-yl)-1,3-thiazol-2-yl]methyl}piperidine-3-carboxamide × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.6 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.10 Å
9O3E Plasmodium falciparum 20S proteasome bound to inhibitor 159 Deposited 2025-04-07	Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric	Chain G 1–252（252 aa） Chain U 1–252（252 aa）	Not recorded	A1B74 (3S)-N~3~-{(1S)-1-[4-(4-cyanophenyl)-1,3-thiazol-2-yl]ethyl}-N~1~-ethoxypiperidine-1,3-dicarboxamide × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.6 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.79 Å
9O3F Plasmodium falciparum 20S proteasome bound to inhibitor 296 Deposited 2025-04-07	Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric	Chain G 1–252（252 aa） Chain U 1–252（252 aa）	Not recorded	A1B73 (3S)-1-({[(3S)-piperidin-3-yl]oxy}acetyl)-N-({4-[4-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl}methyl)piperidine-3-carboxamide × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.6 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.28 Å
9Y0L Incorrectly assembled half-Pf20S Deposited 2025-08-28	Different construct Different mutation/modification Different oligomeric state Different ligand/ion	Assembly 1 Protein heterocomplex Heteromer；Protein × 15 PDB declaration: pentadecameric	Chain G 1–252（252 aa）	Not recorded	No recorded non-water small molecule	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.00 Å
9Y1O The structure of the Plasmodium falciparum 20S proteasome Deposited 2025-08-29	Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric	Chain G 1–252（252 aa） Chain U 1–252（252 aa）	Not recorded	No recorded non-water small molecule	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.10 Å
9YUY Structure of the Plasmodium falciparum 20S proteasome in complex with a beta5-selective covalent syringolin analogue inhibitor. Deposited 2025-10-23	Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric	Chain G 1–252（252 aa） Chain U 1–252（252 aa）	Not recorded	A1CY6 methyl N-{[(2R)-1-({(5R,8R)-5-[(3-fluorophenyl)methyl]-2,7-dioxo-1,6-diazacyclododecan-8-yl}amino)-1-oxo-3-phenylpropan-2-yl]carbamoyl}-L-valinate × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.70 Å

13 other PDB entries and 13 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence

UniProt name	O77396_PLAF7
Isoform	—
PDB entities	7
Chains and sequence ranges	Author chain G； PDBConstruct 1–252； UniProt 1–252 Author chain U； PDBConstruct 1–252； UniProt 1–252

Proteasome endopeptidase complex

Plasmodium falciparum Dd2

UniProt A0A0L7M1M6

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein heterocomplex Heteromer Protein × 28 PDB declaration: 28-meric（28） Consistent with protein copy count	Chain H； UniProt 31–282 Chain V； UniProt 31–282	Not recorded	Proteasome subunit alpha type-6 × 2 （Q8IAR3） Proteasome subunit alpha type-2 × 2 （C6KST3） Proteasome subunit alpha type-3 × 2 （Q8IDG3） Proteasome subunit alpha type-4 × 2 （Q8IDG2） Proteasome subunit alpha type-5 × 2 （A0A0L7LVZ5） Proteasome subunit alpha type-1 × 2 （Q8IK90） Proteasome subunit alpha type-3 × 2 （O77396） Proteasome subunit beta-2 × 2 （Q8I6T3） Proteasome subunit beta-3 × 2 （Q8I261） Proteasome subunit beta-4 × 2 （Q8IKC9） Proteasome subunit beta × 2 （A0A024W8G7） Proteasome subunit beta × 2 （A0A2I0BU46） Proteasome subunit beta × 2 A1CRO N,N-diethyl-N~2~-hexanoyl-D-asparaginyl-N-{(1S)-2-(2,4-difluorophenyl)-1-[(2S,3S,5S,6S)-5-formyl-2-hydroxy-3-(hydroxymethyl)-3,6-dimethylmorpholin-2-yl]ethyl}-4-fluoro-L-phenylalaninamide × 2	ELECTRON MICROSCOPY cryo-EM buffer：pH 7.5 cryo-EM vitrification conditions：Cryogen ETHANE	Resolution 3.00 Å

Other States of the Same Protein in the Database

Other PDB	Difference from Current Entry 9Y0K	Assembly / Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Non-polymers	Method and Experimental Conditions	Structure Quality
8G6F Structure of the Plasmodium falciparum 20S proteasome beta-6 A117D mutant complexed with inhibitor WLW-vs Deposited 2023-02-15	Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric	Chain H 31–282（252 aa） Chain V 31–282（252 aa）	Not recorded	7F1 (2S)-N-[(E,2S)-1-(1H-indol-3-yl)-4-methylsulfonyl-but-3-en-2-yl]-2-[[(2S)-3-(1H-indol-3-yl)-2-(2-morpholin-4-ylethanoylamino)propanoyl]amino]-4-methyl-pentanamide × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.58 Å
9Y0L Incorrectly assembled half-Pf20S Deposited 2025-08-28	Different construct Different mutation/modification Different oligomeric state Different ligand/ion	Assembly 1 Protein heterocomplex Heteromer；Protein × 15 PDB declaration: pentadecameric	Chain H 1–282（282 aa）	Not recorded	No recorded non-water small molecule	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.00 Å
9Y1O The structure of the Plasmodium falciparum 20S proteasome Deposited 2025-08-29	Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric	Chain H 31–282（252 aa） Chain V 31–282（252 aa）	Not recorded	No recorded non-water small molecule	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.10 Å

3 other PDB entries and 3 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence

UniProt name	A0A0L7M1M6_PLAF4
Isoform	—
PDB entities	8
Chains and sequence ranges	Author chain H； PDBConstruct 1–252； UniProt 31–282 Author chain V； PDBConstruct 1–252； UniProt 31–282

Proteasome subunit beta-2

Plasmodium falciparum Dd2

UniProt Q8I6T3

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein heterocomplex Heteromer Protein × 28 PDB declaration: 28-meric（28） Consistent with protein copy count	Chain I； UniProt 42–270 Chain W； UniProt 42–270	Not recorded	Proteasome subunit alpha type-6 × 2 （Q8IAR3） Proteasome subunit alpha type-2 × 2 （C6KST3） Proteasome subunit alpha type-3 × 2 （Q8IDG3） Proteasome subunit alpha type-4 × 2 （Q8IDG2） Proteasome subunit alpha type-5 × 2 （A0A0L7LVZ5） Proteasome subunit alpha type-1 × 2 （Q8IK90） Proteasome subunit alpha type-3 × 2 （O77396） Proteasome endopeptidase complex × 2 （A0A0L7M1M6） Proteasome subunit beta-3 × 2 （Q8I261） Proteasome subunit beta-4 × 2 （Q8IKC9） Proteasome subunit beta × 2 （A0A024W8G7） Proteasome subunit beta × 2 （A0A2I0BU46） Proteasome subunit beta × 2 A1CRO N,N-diethyl-N~2~-hexanoyl-D-asparaginyl-N-{(1S)-2-(2,4-difluorophenyl)-1-[(2S,3S,5S,6S)-5-formyl-2-hydroxy-3-(hydroxymethyl)-3,6-dimethylmorpholin-2-yl]ethyl}-4-fluoro-L-phenylalaninamide × 2	ELECTRON MICROSCOPY cryo-EM buffer：pH 7.5 cryo-EM vitrification conditions：Cryogen ETHANE	Resolution 3.00 Å

Other States of the Same Protein in the Database

Other PDB	Difference from Current Entry 9Y0K	Assembly / Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Non-polymers	Method and Experimental Conditions	Structure Quality
5FMG Structure and function based design of Plasmodium-selective proteasome inhibitors Deposited 2015-11-04	Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric	Chain I 42–270（229 aa） Chain W 42–270（229 aa）	Not recorded	7F1 (2S)-N-[(E,2S)-1-(1H-indol-3-yl)-4-methylsulfonyl-but-3-en-2-yl]-2-[[(2S)-3-(1H-indol-3-yl)-2-(2-morpholin-4-ylethanoylamino)propanoyl]amino]-4-methyl-pentanamide × 2	ELECTRON MICROSCOPY cryo-EM buffer 50MM TRIS HCL, 5MM MGCL2, 1MM DITHIOTREITOL；pH 7.5；50MM TRIS HCL, 5MM MGCL2, 1MM DITHIOTREITOL cryo-EM vitrification conditions Cryogen ETHANE；VITRIFICATION 1 -- CRYOGEN- ETHANE, HUMIDITY- 95, INSTRUMENT- FEI VITROBOT MARK III, METHOD- BLOT 2.5 SECONDS BEFORE PLUNGING,	Resolution 3.60 Å
6MUV The structure of the Plasmodium falciparum 20S proteasome in complex with two PA28 activators Deposited 2018-10-23	Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 42 PDB declaration: 42-meric	Chain I 42–270（229 aa） Chain W 42–270（229 aa）	Not recorded	No recorded non-water small molecule	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE；wait time 0sec blot time 2sec blot force -1	Resolution 3.80 Å
6MUW The structure of the Plasmodium falciparum 20S proteasome. Deposited 2018-10-23	Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric	Chain I 42–270（229 aa） Chain W 42–270（229 aa）	Not recorded	No recorded non-water small molecule	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE；wait time 0sec blot time 2sec blot force -1	Resolution 3.60 Å
6MUX The structure of the Plasmodium falciparum 20S proteasome in complex with one PA28 activator Deposited 2018-10-23	Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 35 PDB declaration: 35-meric	Chain I 42–270（229 aa） Chain W 42–270（229 aa）	Not recorded	No recorded non-water small molecule	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE；wait time 0sec blot time 2sec blot force -1	Resolution 3.90 Å
7LXT Structure of Plasmodium falciparum 20S proteasome with bound bortezomib Deposited 2021-03-05	Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric	Chain I 42–270（229 aa） Chain W 42–270（229 aa）	Not recorded	BO2 N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE × 6	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.40 Å
7LXU Structure of Plasmodium falciparum 20S proteasome with bound MPI-5 Deposited 2021-03-05	Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric	Chain I 42–270（229 aa） Chain W 42–270（229 aa）	Not recorded	YHD N-[(1R)-2-([1,1'-biphenyl]-4-yl)-1-boronoethyl]-1-methyl-L-prolinamide × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.10 Å
8G6F Structure of the Plasmodium falciparum 20S proteasome beta-6 A117D mutant complexed with inhibitor WLW-vs Deposited 2023-02-15	Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric	Chain I 42–270（229 aa） Chain W 42–270（229 aa）	Not recorded	7F1 (2S)-N-[(E,2S)-1-(1H-indol-3-yl)-4-methylsulfonyl-but-3-en-2-yl]-2-[[(2S)-3-(1H-indol-3-yl)-2-(2-morpholin-4-ylethanoylamino)propanoyl]amino]-4-methyl-pentanamide × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.58 Å
8W2F Plasmodium falciparum 20S proteasome bound to an inhibitor Deposited 2024-02-20	Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric	Chain I 42–270（229 aa） Chain W 42–270（229 aa）	Not recorded	A1AE6 (3S)-1-[(2-fluoroethoxy)acetyl]-N-{[(4P)-4-(6-methylpyridin-3-yl)-1,3-thiazol-2-yl]methyl}piperidine-3-carboxamide × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.6 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.10 Å
9O3E Plasmodium falciparum 20S proteasome bound to inhibitor 159 Deposited 2025-04-07	Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric	Chain I 42–270（229 aa） Chain W 42–270（229 aa）	Not recorded	A1B74 (3S)-N~3~-{(1S)-1-[4-(4-cyanophenyl)-1,3-thiazol-2-yl]ethyl}-N~1~-ethoxypiperidine-1,3-dicarboxamide × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.6 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.79 Å
9O3F Plasmodium falciparum 20S proteasome bound to inhibitor 296 Deposited 2025-04-07	Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric	Chain I 42–270（229 aa） Chain W 42–270（229 aa）	Not recorded	A1B73 (3S)-1-({[(3S)-piperidin-3-yl]oxy}acetyl)-N-({4-[4-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl}methyl)piperidine-3-carboxamide × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.6 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.28 Å
9Y1O The structure of the Plasmodium falciparum 20S proteasome Deposited 2025-08-29	Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric	Chain I 42–270（229 aa） Chain W 42–270（229 aa）	Not recorded	No recorded non-water small molecule	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.10 Å
9YUY Structure of the Plasmodium falciparum 20S proteasome in complex with a beta5-selective covalent syringolin analogue inhibitor. Deposited 2025-10-23	Different construct Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric	Chain I 1–270（270 aa） Chain W 1–270（270 aa）	Not recorded	A1CY6 methyl N-{[(2R)-1-({(5R,8R)-5-[(3-fluorophenyl)methyl]-2,7-dioxo-1,6-diazacyclododecan-8-yl}amino)-1-oxo-3-phenylpropan-2-yl]carbamoyl}-L-valinate × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.70 Å

12 other PDB entries and 12 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence

UniProt name	Q8I6T3_PLAF7
Isoform	—
PDB entities	9
Chains and sequence ranges	Author chain I； PDBConstruct 1–229； UniProt 42–270 Author chain W； PDBConstruct 1–229； UniProt 42–270

Proteasome subunit beta-3

Plasmodium falciparum Dd2

UniProt Q8I261

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein heterocomplex Heteromer Protein × 28 PDB declaration: 28-meric（28） Consistent with protein copy count	Chain J； UniProt 1–218 Chain X； UniProt 1–218	Not recorded	Proteasome subunit alpha type-6 × 2 （Q8IAR3） Proteasome subunit alpha type-2 × 2 （C6KST3） Proteasome subunit alpha type-3 × 2 （Q8IDG3） Proteasome subunit alpha type-4 × 2 （Q8IDG2） Proteasome subunit alpha type-5 × 2 （A0A0L7LVZ5） Proteasome subunit alpha type-1 × 2 （Q8IK90） Proteasome subunit alpha type-3 × 2 （O77396） Proteasome endopeptidase complex × 2 （A0A0L7M1M6） Proteasome subunit beta-2 × 2 （Q8I6T3） Proteasome subunit beta-4 × 2 （Q8IKC9） Proteasome subunit beta × 2 （A0A024W8G7） Proteasome subunit beta × 2 （A0A2I0BU46） Proteasome subunit beta × 2 A1CRO N,N-diethyl-N~2~-hexanoyl-D-asparaginyl-N-{(1S)-2-(2,4-difluorophenyl)-1-[(2S,3S,5S,6S)-5-formyl-2-hydroxy-3-(hydroxymethyl)-3,6-dimethylmorpholin-2-yl]ethyl}-4-fluoro-L-phenylalaninamide × 2	ELECTRON MICROSCOPY cryo-EM buffer：pH 7.5 cryo-EM vitrification conditions：Cryogen ETHANE	Resolution 3.00 Å

Other States of the Same Protein in the Database

Other PDB	Difference from Current Entry 9Y0K	Assembly / Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Non-polymers	Method and Experimental Conditions	Structure Quality
5FMG Structure and function based design of Plasmodium-selective proteasome inhibitors Deposited 2015-11-04	Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric	Chain J 1–204（204 aa） Chain X 1–204（204 aa）	Not recorded	7F1 (2S)-N-[(E,2S)-1-(1H-indol-3-yl)-4-methylsulfonyl-but-3-en-2-yl]-2-[[(2S)-3-(1H-indol-3-yl)-2-(2-morpholin-4-ylethanoylamino)propanoyl]amino]-4-methyl-pentanamide × 2	ELECTRON MICROSCOPY cryo-EM buffer 50MM TRIS HCL, 5MM MGCL2, 1MM DITHIOTREITOL；pH 7.5；50MM TRIS HCL, 5MM MGCL2, 1MM DITHIOTREITOL cryo-EM vitrification conditions Cryogen ETHANE；VITRIFICATION 1 -- CRYOGEN- ETHANE, HUMIDITY- 95, INSTRUMENT- FEI VITROBOT MARK III, METHOD- BLOT 2.5 SECONDS BEFORE PLUNGING,	Resolution 3.60 Å
6MUV The structure of the Plasmodium falciparum 20S proteasome in complex with two PA28 activators Deposited 2018-10-23	Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 42 PDB declaration: 42-meric	Chain J 1–218（218 aa） Chain X 1–218（218 aa）	Not recorded	No recorded non-water small molecule	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE；wait time 0sec blot time 2sec blot force -1	Resolution 3.80 Å
6MUW The structure of the Plasmodium falciparum 20S proteasome. Deposited 2018-10-23	Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric	Chain J 1–218（218 aa） Chain X 1–218（218 aa）	Not recorded	No recorded non-water small molecule	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE；wait time 0sec blot time 2sec blot force -1	Resolution 3.60 Å
6MUX The structure of the Plasmodium falciparum 20S proteasome in complex with one PA28 activator Deposited 2018-10-23	Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 35 PDB declaration: 35-meric	Chain J 1–218（218 aa） Chain X 1–218（218 aa）	Not recorded	No recorded non-water small molecule	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE；wait time 0sec blot time 2sec blot force -1	Resolution 3.90 Å
7LXT Structure of Plasmodium falciparum 20S proteasome with bound bortezomib Deposited 2021-03-05	Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric	Chain J 1–218（218 aa） Chain X 1–218（218 aa）	Not recorded	BO2 N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE × 6	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.40 Å
7LXU Structure of Plasmodium falciparum 20S proteasome with bound MPI-5 Deposited 2021-03-05	Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric	Chain J 1–218（218 aa） Chain X 1–218（218 aa）	Not recorded	YHD N-[(1R)-2-([1,1'-biphenyl]-4-yl)-1-boronoethyl]-1-methyl-L-prolinamide × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.10 Å
8G6F Structure of the Plasmodium falciparum 20S proteasome beta-6 A117D mutant complexed with inhibitor WLW-vs Deposited 2023-02-15	Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric	Chain J 1–218（218 aa） Chain X 1–218（218 aa）	Not recorded	7F1 (2S)-N-[(E,2S)-1-(1H-indol-3-yl)-4-methylsulfonyl-but-3-en-2-yl]-2-[[(2S)-3-(1H-indol-3-yl)-2-(2-morpholin-4-ylethanoylamino)propanoyl]amino]-4-methyl-pentanamide × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.58 Å
8W2F Plasmodium falciparum 20S proteasome bound to an inhibitor Deposited 2024-02-20	Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric	Chain J 1–218（218 aa） Chain X 1–218（218 aa）	Not recorded	A1AE6 (3S)-1-[(2-fluoroethoxy)acetyl]-N-{[(4P)-4-(6-methylpyridin-3-yl)-1,3-thiazol-2-yl]methyl}piperidine-3-carboxamide × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.6 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.10 Å
9O3E Plasmodium falciparum 20S proteasome bound to inhibitor 159 Deposited 2025-04-07	Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric	Chain J 1–218（218 aa） Chain X 1–218（218 aa）	Not recorded	A1B74 (3S)-N~3~-{(1S)-1-[4-(4-cyanophenyl)-1,3-thiazol-2-yl]ethyl}-N~1~-ethoxypiperidine-1,3-dicarboxamide × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.6 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.79 Å
9O3F Plasmodium falciparum 20S proteasome bound to inhibitor 296 Deposited 2025-04-07	Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric	Chain J 1–218（218 aa） Chain X 1–218（218 aa）	Not recorded	A1B73 (3S)-1-({[(3S)-piperidin-3-yl]oxy}acetyl)-N-({4-[4-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl}methyl)piperidine-3-carboxamide × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.6 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.28 Å
9Y0L Incorrectly assembled half-Pf20S Deposited 2025-08-28	Different construct Different mutation/modification Different oligomeric state Different ligand/ion	Assembly 1 Protein heterocomplex Heteromer；Protein × 15 PDB declaration: pentadecameric	Chain J 1–218（218 aa）	Not recorded	No recorded non-water small molecule	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.00 Å
9Y1O The structure of the Plasmodium falciparum 20S proteasome Deposited 2025-08-29	Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric	Chain J 1–218（218 aa） Chain X 1–218（218 aa）	Not recorded	No recorded non-water small molecule	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.10 Å
9YUY Structure of the Plasmodium falciparum 20S proteasome in complex with a beta5-selective covalent syringolin analogue inhibitor. Deposited 2025-10-23	Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric	Chain J 1–218（218 aa） Chain X 1–218（218 aa）	Not recorded	A1CY6 methyl N-{[(2R)-1-({(5R,8R)-5-[(3-fluorophenyl)methyl]-2,7-dioxo-1,6-diazacyclododecan-8-yl}amino)-1-oxo-3-phenylpropan-2-yl]carbamoyl}-L-valinate × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.70 Å

13 other PDB entries and 13 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence

UniProt name	Q8I261_PLAF7
Isoform	—
PDB entities	10
Chains and sequence ranges	Author chain J； PDBConstruct 1–218； UniProt 1–218 Author chain X； PDBConstruct 1–218； UniProt 1–218

Proteasome subunit beta-4

Plasmodium falciparum Dd2

UniProt Q8IKC9

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein heterocomplex Heteromer Protein × 28 PDB declaration: 28-meric（28） Consistent with protein copy count	Chain K； UniProt 1–195 Chain Y； UniProt 1–195	Not recorded	Proteasome subunit alpha type-6 × 2 （Q8IAR3） Proteasome subunit alpha type-2 × 2 （C6KST3） Proteasome subunit alpha type-3 × 2 （Q8IDG3） Proteasome subunit alpha type-4 × 2 （Q8IDG2） Proteasome subunit alpha type-5 × 2 （A0A0L7LVZ5） Proteasome subunit alpha type-1 × 2 （Q8IK90） Proteasome subunit alpha type-3 × 2 （O77396） Proteasome endopeptidase complex × 2 （A0A0L7M1M6） Proteasome subunit beta-2 × 2 （Q8I6T3） Proteasome subunit beta-3 × 2 （Q8I261） Proteasome subunit beta × 2 （A0A024W8G7） Proteasome subunit beta × 2 （A0A2I0BU46） Proteasome subunit beta × 2 A1CRO N,N-diethyl-N~2~-hexanoyl-D-asparaginyl-N-{(1S)-2-(2,4-difluorophenyl)-1-[(2S,3S,5S,6S)-5-formyl-2-hydroxy-3-(hydroxymethyl)-3,6-dimethylmorpholin-2-yl]ethyl}-4-fluoro-L-phenylalaninamide × 2	ELECTRON MICROSCOPY cryo-EM buffer：pH 7.5 cryo-EM vitrification conditions：Cryogen ETHANE	Resolution 3.00 Å

Other States of the Same Protein in the Database

Other PDB	Difference from Current Entry 9Y0K	Assembly / Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Non-polymers	Method and Experimental Conditions	Structure Quality
5FMG Structure and function based design of Plasmodium-selective proteasome inhibitors Deposited 2015-11-04	Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric	Chain K 1–195（195 aa） Chain Y 1–195（195 aa）	Not recorded	7F1 (2S)-N-[(E,2S)-1-(1H-indol-3-yl)-4-methylsulfonyl-but-3-en-2-yl]-2-[[(2S)-3-(1H-indol-3-yl)-2-(2-morpholin-4-ylethanoylamino)propanoyl]amino]-4-methyl-pentanamide × 2	ELECTRON MICROSCOPY cryo-EM buffer 50MM TRIS HCL, 5MM MGCL2, 1MM DITHIOTREITOL；pH 7.5；50MM TRIS HCL, 5MM MGCL2, 1MM DITHIOTREITOL cryo-EM vitrification conditions Cryogen ETHANE；VITRIFICATION 1 -- CRYOGEN- ETHANE, HUMIDITY- 95, INSTRUMENT- FEI VITROBOT MARK III, METHOD- BLOT 2.5 SECONDS BEFORE PLUNGING,	Resolution 3.60 Å
6MUV The structure of the Plasmodium falciparum 20S proteasome in complex with two PA28 activators Deposited 2018-10-23	Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 42 PDB declaration: 42-meric	Chain K 1–195（195 aa） Chain Y 1–195（195 aa）	Not recorded	No recorded non-water small molecule	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE；wait time 0sec blot time 2sec blot force -1	Resolution 3.80 Å
6MUW The structure of the Plasmodium falciparum 20S proteasome. Deposited 2018-10-23	Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric	Chain K 1–195（195 aa） Chain Y 1–195（195 aa）	Not recorded	No recorded non-water small molecule	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE；wait time 0sec blot time 2sec blot force -1	Resolution 3.60 Å
6MUX The structure of the Plasmodium falciparum 20S proteasome in complex with one PA28 activator Deposited 2018-10-23	Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 35 PDB declaration: 35-meric	Chain K 1–195（195 aa） Chain Y 1–195（195 aa）	Not recorded	No recorded non-water small molecule	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE；wait time 0sec blot time 2sec blot force -1	Resolution 3.90 Å
7LXT Structure of Plasmodium falciparum 20S proteasome with bound bortezomib Deposited 2021-03-05	Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric	Chain K 1–195（195 aa） Chain Y 1–195（195 aa）	Not recorded	BO2 N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE × 6	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.40 Å
7LXU Structure of Plasmodium falciparum 20S proteasome with bound MPI-5 Deposited 2021-03-05	Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric	Chain K 1–195（195 aa） Chain Y 1–195（195 aa）	Not recorded	YHD N-[(1R)-2-([1,1'-biphenyl]-4-yl)-1-boronoethyl]-1-methyl-L-prolinamide × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.10 Å
8G6F Structure of the Plasmodium falciparum 20S proteasome beta-6 A117D mutant complexed with inhibitor WLW-vs Deposited 2023-02-15	Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric	Chain K 1–195（195 aa） Chain Y 1–195（195 aa）	Not recorded	7F1 (2S)-N-[(E,2S)-1-(1H-indol-3-yl)-4-methylsulfonyl-but-3-en-2-yl]-2-[[(2S)-3-(1H-indol-3-yl)-2-(2-morpholin-4-ylethanoylamino)propanoyl]amino]-4-methyl-pentanamide × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.58 Å
8W2F Plasmodium falciparum 20S proteasome bound to an inhibitor Deposited 2024-02-20	Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric	Chain K 1–195（195 aa） Chain Y 1–195（195 aa）	Not recorded	A1AE6 (3S)-1-[(2-fluoroethoxy)acetyl]-N-{[(4P)-4-(6-methylpyridin-3-yl)-1,3-thiazol-2-yl]methyl}piperidine-3-carboxamide × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.6 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.10 Å
9O3E Plasmodium falciparum 20S proteasome bound to inhibitor 159 Deposited 2025-04-07	Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric	Chain K 1–195（195 aa） Chain Y 1–195（195 aa）	Not recorded	A1B74 (3S)-N~3~-{(1S)-1-[4-(4-cyanophenyl)-1,3-thiazol-2-yl]ethyl}-N~1~-ethoxypiperidine-1,3-dicarboxamide × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.6 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.79 Å
9O3F Plasmodium falciparum 20S proteasome bound to inhibitor 296 Deposited 2025-04-07	Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric	Chain K 1–195（195 aa） Chain Y 1–195（195 aa）	Not recorded	A1B73 (3S)-1-({[(3S)-piperidin-3-yl]oxy}acetyl)-N-({4-[4-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl}methyl)piperidine-3-carboxamide × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.6 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.28 Å
9Y0L Incorrectly assembled half-Pf20S Deposited 2025-08-28	Different construct Different mutation/modification Different oligomeric state Different ligand/ion	Assembly 1 Protein heterocomplex Heteromer；Protein × 15 PDB declaration: pentadecameric	Chain K 1–195（195 aa）	Not recorded	No recorded non-water small molecule	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.00 Å
9Y1O The structure of the Plasmodium falciparum 20S proteasome Deposited 2025-08-29	Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric	Chain K 1–195（195 aa） Chain Y 1–195（195 aa）	Not recorded	No recorded non-water small molecule	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.10 Å
9YUY Structure of the Plasmodium falciparum 20S proteasome in complex with a beta5-selective covalent syringolin analogue inhibitor. Deposited 2025-10-23	Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric	Chain K 1–195（195 aa） Chain Y 1–195（195 aa）	Not recorded	A1CY6 methyl N-{[(2R)-1-({(5R,8R)-5-[(3-fluorophenyl)methyl]-2,7-dioxo-1,6-diazacyclododecan-8-yl}amino)-1-oxo-3-phenylpropan-2-yl]carbamoyl}-L-valinate × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.70 Å

13 other PDB entries and 13 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence

UniProt name	Q8IKC9_PLAF7
Isoform	—
PDB entities	11
Chains and sequence ranges	Author chain K； PDBConstruct 1–195； UniProt 1–195 Author chain Y； PDBConstruct 1–195； UniProt 1–195

Proteasome subunit beta

Plasmodium falciparum Dd2

UniProt A0A024W8G7

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein heterocomplex Heteromer Protein × 28 PDB declaration: 28-meric（28） Consistent with protein copy count	Chain L； UniProt 53–262 Chain Z； UniProt 53–262	Not recorded	Proteasome subunit alpha type-6 × 2 （Q8IAR3） Proteasome subunit alpha type-2 × 2 （C6KST3） Proteasome subunit alpha type-3 × 2 （Q8IDG3） Proteasome subunit alpha type-4 × 2 （Q8IDG2） Proteasome subunit alpha type-5 × 2 （A0A0L7LVZ5） Proteasome subunit alpha type-1 × 2 （Q8IK90） Proteasome subunit alpha type-3 × 2 （O77396） Proteasome endopeptidase complex × 2 （A0A0L7M1M6） Proteasome subunit beta-2 × 2 （Q8I6T3） Proteasome subunit beta-3 × 2 （Q8I261） Proteasome subunit beta-4 × 2 （Q8IKC9） Proteasome subunit beta × 2 （A0A2I0BU46） Proteasome subunit beta × 2 A1CRO N,N-diethyl-N~2~-hexanoyl-D-asparaginyl-N-{(1S)-2-(2,4-difluorophenyl)-1-[(2S,3S,5S,6S)-5-formyl-2-hydroxy-3-(hydroxymethyl)-3,6-dimethylmorpholin-2-yl]ethyl}-4-fluoro-L-phenylalaninamide × 2	ELECTRON MICROSCOPY cryo-EM buffer：pH 7.5 cryo-EM vitrification conditions：Cryogen ETHANE	Resolution 3.00 Å

Other States of the Same Protein in the Database

No other PDB entry for the same UniProt protein was found.

View Construct and Data Evidence

UniProt name	A0A024W8G7_PLAFA
Isoform	—
PDB entities	12
Chains and sequence ranges	Author chain L； PDBConstruct 1–210； UniProt 53–262 Author chain Z； PDBConstruct 1–210； UniProt 53–262

Proteasome subunit beta

Plasmodium falciparum Dd2

UniProt A0A2I0BU46

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein heterocomplex Heteromer Protein × 28 PDB declaration: 28-meric（28） Consistent with protein copy count	Chain M； UniProt 1–240 Chain a； UniProt 1–240	Not recorded	Proteasome subunit alpha type-6 × 2 （Q8IAR3） Proteasome subunit alpha type-2 × 2 （C6KST3） Proteasome subunit alpha type-3 × 2 （Q8IDG3） Proteasome subunit alpha type-4 × 2 （Q8IDG2） Proteasome subunit alpha type-5 × 2 （A0A0L7LVZ5） Proteasome subunit alpha type-1 × 2 （Q8IK90） Proteasome subunit alpha type-3 × 2 （O77396） Proteasome endopeptidase complex × 2 （A0A0L7M1M6） Proteasome subunit beta-2 × 2 （Q8I6T3） Proteasome subunit beta-3 × 2 （Q8I261） Proteasome subunit beta-4 × 2 （Q8IKC9） Proteasome subunit beta × 2 （A0A024W8G7） Proteasome subunit beta × 2 A1CRO N,N-diethyl-N~2~-hexanoyl-D-asparaginyl-N-{(1S)-2-(2,4-difluorophenyl)-1-[(2S,3S,5S,6S)-5-formyl-2-hydroxy-3-(hydroxymethyl)-3,6-dimethylmorpholin-2-yl]ethyl}-4-fluoro-L-phenylalaninamide × 2	ELECTRON MICROSCOPY cryo-EM buffer：pH 7.5 cryo-EM vitrification conditions：Cryogen ETHANE	Resolution 3.00 Å

Other States of the Same Protein in the Database

Other PDB	Difference from Current Entry 9Y0K	Assembly / Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Non-polymers	Method and Experimental Conditions	Structure Quality
8G6E Structure of the Plasmodium falciparum 20S proteasome complexed with inhibitor TDI-8304 Deposited 2023-02-15	Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric	Chain M 1–240（240 aa） Chain a 1–240（240 aa）	Not recorded	YRE (7S,10S,13S)-N-cyclopentyl-10-[2-(morpholin-4-yl)ethyl]-9,12-dioxo-13-(2-oxopyrrolidin-1-yl)-2-oxa-8,11-diazabicyclo[13.3.1]nonadeca-1(19),15,17-triene-7-carboxamide × 6	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.18 Å
8G6F Structure of the Plasmodium falciparum 20S proteasome beta-6 A117D mutant complexed with inhibitor WLW-vs Deposited 2023-02-15	Different mutation/modification Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric	Chain M 1–240（240 aa） Chain a 1–240（240 aa）	Mutation：A117D Mutation：A117D	7F1 (2S)-N-[(E,2S)-1-(1H-indol-3-yl)-4-methylsulfonyl-but-3-en-2-yl]-2-[[(2S)-3-(1H-indol-3-yl)-2-(2-morpholin-4-ylethanoylamino)propanoyl]amino]-4-methyl-pentanamide × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.58 Å
9Y0L Incorrectly assembled half-Pf20S Deposited 2025-08-28	Different construct Different mutation/modification Different oligomeric state Different ligand/ion	Assembly 1 Protein heterocomplex Heteromer；Protein × 15 PDB declaration: pentadecameric	Chain M 1–240（240 aa）	Not recorded	No recorded non-water small molecule	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.00 Å
9Y1O The structure of the Plasmodium falciparum 20S proteasome Deposited 2025-08-29	Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric	Chain M 1–240（240 aa） Chain a 1–240（240 aa）	Not recorded	No recorded non-water small molecule	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.10 Å

4 other PDB entries and 4 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence

UniProt name	A0A2I0BU46_PLAFO
Isoform	—
PDB entities	13
Chains and sequence ranges	Author chain M； PDBConstruct 1–240； UniProt 1–240 Author chain a； PDBConstruct 1–240； UniProt 1–240

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

SAXS scattering curve SAXS Profile

P(r) Distance Distribution P(r) Distribution

Download Download SAXS (.dat) P(r) (.pr.out) CIF

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2. Structure Basics 2. Structure Basics

Entry ID entry_id	9y0k
Deposition date deposition_date	2025-08-28
Structure title title	Structure of Plasmodium falciparum 20S proteasome with bound J80
Keywords keywords	Proteasome, 20S proteasome, Plasmodium falciparum, proteasome inhibitor, HYDROLASE-INHIBITOR complex; HYDROLASE/INHIBITOR
Experimental Method method	ELECTRON MICROSCOPY

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3. SAXS Parameters (CRYSOL theoretical calculation) 3. SAXS Parameters (CRYSOL)

Radius of gyration Rg (Guinier) rg_guinier	60.03 Å
Radius of gyration Rg (electron density) rg_electron	59.58 Å
Forward intensity I(0) i0	12736100000.00
Molecular weight molecular_weight	636200.0 kDa
Excluded volume excluded_volume	618100 Å³
Envelope volume envelope_volume	1242700 Å³
Hydration-shell volume shell_volume	167350 Å³
Envelope diameter envelope_diameter	193.4 Å
Shell Rg shell_rg	67.59 Å
Envelope Rg envelope_rg	57.41 Å
Shape Rg shape_rg	59.58 Å
Total Rg total_rg	59.70 Å
Total atoms total_atoms	48226
Residues n_residues	6248
Spherical-harmonic order n_harmonics	20
q range q_range	— – 0.5000 Å⁻¹
Data points n_points	101
Shell type shell_type	directional
Solvent electron density solvent_density	0.3340 e/Å³
Shell contrast contrast_shell	0.0300 e/Å³
CRYSOL version crysol_version	4.1.3

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4. P(r) Distance Distribution (GNOM inversion) 4. P(r) Analysis (GNOM)

Maximum dimension Dmax dmax	189.0 Å
Rg (real space) rg_real	59.73 Å
Rg uncertainty (real space) rg_real_error	1.74 Å
I(0) (real space) i0_real	1.2740e+10
I(0) uncertainty (real space) i0_real_error	2.7330e+08
Rg (reciprocal space) rg_reciprocal	60.26 Å
I(0) (reciprocal space) i0_reciprocal	12750000000.0000
Solution quality estimate total_estimate	0.8099
Solution quality rating solution_quality	GOOD a GOOD solution
P(r) peaks n_peaks	2
Primary peak position r_peak_primary	80.0 Å
Skewness Skewness skewness	0.192
Kurtosis Kurtosis kurtosis	-0.436
Angular range angular_range	— – 0.1300 Å⁻¹
Current regularization parameter α current_alpha	0.0000
Highest regularization parameter α highest_alpha	886000000.0000
Real-space data points n_real_points	27
GNOM version gnom_version	4.1.3
Quality Criteria quality_criteria	AN1: 0.000; Oscil: 0.855; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.961; Smooth: 0.000

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5. Crystallography and Experiment 5. Crystallography & Experiment

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6. Entities and Polymers Entities & Polymers (15)

Entity 1 Entity 1 polymer

Description description	Proteasome subunit alpha type-6
Molecular weight formula_weight	29531.7 kDa
EC 编号 ec_number	3.4.25.1
Source method src_method	man
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	A,O
Atom count atom_count	48226

MVRPSQSMYDRHLTIFSPDGNLYQIEYAIKAVKNTNITSVGVKGENCAVIISQKKMATQYISQDKLLDYNNITNIYNITDEIGCSMVGMPGDCLSMVYKARSEASEFLYSNGYNVNAETLCRNICDKIQVYTQHAYMRLHACSGMIIGIDENNKPELFKFDPSGFCAGYRACVIGNKEQESISVLERLLEKRKKKIQQETIDEDIRNTTILAIEALQTILAFDLKASEIEVAIVSTKNRNFTQISEKEIDNYLTYIAERD

来源 Source

来源生物 organism	Plasmodium falciparum Dd2
NCBI Class编号 ncbi_taxonomy_id	57267
宿主生物 host_organism	Spodoptera frugiperda

Entity 2 Entity 2 polymer

Description description	Proteasome subunit alpha type-2
Molecular weight formula_weight	26556.4 kDa
Source method src_method	man
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	B,P

MADGEYSFSLTTFSPTGKLVQIEYALNRVSSSSPALGIRAKNGVIIATEKKSPNELIEENSIFKIQQISEHIGIVYAGMPGDFRVLLKRARKEAIRYSLQYGSEILVKELVKIIASIVQEFTQTGGVRPFGLSLLICGVDVYGYHLYQIDPSGCYFNWMATCVGKDYQNNMSFLEKRYNKDIEIEDAIHTAILTLKESYEGVLNEKNIEIGVAYDNKPFKILTQNEIKDYLIEIE

来源 Source

来源生物 organism	Plasmodium falciparum Dd2
NCBI Class编号 ncbi_taxonomy_id	57267
宿主生物 host_organism	Spodoptera frugiperda

Entity 3 Entity 3 polymer

Description description	Proteasome subunit alpha type-3
Molecular weight formula_weight	27977.7 kDa
Source method src_method	man
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	C,Q

MARRYDSRTTTFSPEGRLYQVEYALEAINNASITIGLITKDGVILGADKVFISKLIDKANNYEKIYKIDKHIFCGVAGLNADANILINQSRLYAQRYLYNYNEVQPVSQLVVQICDIKQSYTQYGGLRPYGVSFLIGGYDTKDGYQLYHTDPSGNYSGWFATAIGTNNLTASSVLKQEWKNDMTLEEGLLLALKTLAKSTDTEIPKSEKIELAYLTNKDGEVYQKYLTEKEIEELIKLYTQKYIKE

来源 Source

来源生物 organism	Plasmodium falciparum Dd2
NCBI Class编号 ncbi_taxonomy_id	57267
宿主生物 host_organism	Spodoptera frugiperda

Entity 4 Entity 4 polymer

Description description	Proteasome subunit alpha type-4
Molecular weight formula_weight	27263.3 kDa
Source method src_method	man
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	D,R

MSYDRAITVFSPDGHLLQVEHALEAVKKGGCAVAIKSSNFAVLAVEKKNIPKLQNPKTTEKLIKLDEHNCLAFAGLNADARVLVNKTRLECQRYYLNMDEPAPVDYIAKYVAKVQQKFTHRGGVRPFGIATLIAGFKNNKEICIYQTEPSGIYAAWKAQAIGKNAKIVQEFLEKNYQENMEQKDCIFLALKAIFEVVELSSKNVEVALLTEKDLTFIEEQEINSMVELIDQERTKNNEQNE

来源 Source

来源生物 organism	Plasmodium falciparum Dd2
NCBI Class编号 ncbi_taxonomy_id	57267
宿主生物 host_organism	Spodoptera frugiperda

Entity 5 Entity 5 polymer

Description description	Proteasome subunit alpha type-5
Molecular weight formula_weight	28417.4 kDa
Source method src_method	man
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	E,S

MFSTRSEYDRGVNTFSPEGRLFQVEYALGAIKLGSTAVGICVNDGVILASERRISSTLIEKDSVEKLLSIDDHIGCAMSGLMADARTLIDYARVECNHYKFIYNENINIKSCVELISELALDFSNLSDSKRKKIMSRPFGVALLIGGVDKNGPCLWYTEPSGTNTRFSAASIGSAQEGAELLLQENYKKDMTFEQAEILALTVLRQVMEDKLSTSNVEICAIKKSDQTFYKYNTDDISRIIDVLPSPVYPTIDMTA

来源 Source

来源生物 organism	Plasmodium falciparum Dd2
NCBI Class编号 ncbi_taxonomy_id	57267
宿主生物 host_organism	Spodoptera frugiperda

Entity 6 Entity 6 polymer

Description description	Proteasome subunit alpha type-1
Molecular weight formula_weight	28871.7 kDa
Source method src_method	man
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	F,T

MYRNLYDTDNIIYSPEGRLYQVEYASEAIKQGTCAVAIKSKDYVVVSGLKKCISKLSFPQEKIFKIDDYIGISMSGITSDAKVLTKFMQNECLSHKFLYNENINIESLVRSVADKYQKNTQKSSKRAFGVGLMIAAYHNEPCIFETRPNGSYFEYDALSFGARSHASKTYLEKNLHLFEECSLEELILHCLKALKCSLSSESELTISNTALAVVGKNHPWQEISSLQLEEYLSKVKMDAEQEQVEENVQNEANE

来源 Source

来源生物 organism	Plasmodium falciparum Dd2
NCBI Class编号 ncbi_taxonomy_id	57267
宿主生物 host_organism	Spodoptera frugiperda

Entity 7 Entity 7 polymer

Description description	Proteasome subunit alpha type-3
Molecular weight formula_weight	29324.3 kDa
EC 编号 ec_number	3.4.25.1
Source method src_method	man
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	G,U

MAGLSAGYDLSVSTFSPDGRLYQVEYIYKSINNNNTALCLECKDGIICCCINSNMDKNKMIKKNSYNRIYHVNNNIIITYSGFDGDARNIIDRARSEANTYYYNFHTNIPLHILVNRISLYIHAYTLYWHMRPFAASIIISSFNEKDKGDIYCIEPNGACYKYSGIVIGKNKEMFKTEIEKKDYKDINVRDAIEDIYKFILTSDDHMNKNNLQNLVNFSWICKESSYEFQNIHEEILTPALNKAVEYIEKLN

来源 Source

来源生物 organism	Plasmodium falciparum Dd2
NCBI Class编号 ncbi_taxonomy_id	57267
宿主生物 host_organism	Spodoptera frugiperda

Entity 8 Entity 8 polymer

Description description	Proteasome endopeptidase complex
Molecular weight formula_weight	29143.9 kDa
Source method src_method	man
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	H,V

TTIIGIIYDNGVMLACDSRTSSGTFISNKCSRKINRINENLYVCRSGASAHSQKIIEIIKHYCVSMKNENRKKGRFHEGETIYDETTYDEEIDIDSINYLDYNNNNDNNLVTKNKYFYEDKFNDYNPLVENVAHITKKIIYTNNNFLSCALIFGGYDKIKKQQLYAVNLNGSIIEKHDFAVSGSGSIYIQSYLQDKYKKFMTKKECFNLILNCVKYAMHNDNSSGGLIRIVNITKSFVEEFTVVNTQMNFQY

来源 Source

来源生物 organism	Plasmodium falciparum Dd2
NCBI Class编号 ncbi_taxonomy_id	57267
宿主生物 host_organism	Spodoptera frugiperda

Entity 9 Entity 9 polymer

Description description	Proteasome subunit beta-2
Molecular weight formula_weight	25104.9 kDa
Source method src_method	man
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	I,W

TTICGLVCQNAVILGADTRATEGPIVADKNCSKLHYISKNIWCAGAGVAGDLEHTTLWLQHNVELHRLNTNTQPRVSMCVSRLTQELFKYQGYKVCAIVLGGVDVNGPQLYGIHPHGSSCLLPFTALGSGSLNAMAVLEAKYRDNMTIEEGKNLVCEAICAGIFNDLGSGGNVDICVITKDSYQHIRPYKEPNMRLYHLPHPTIYPKGTTPILSEKIEYIKKFISVEDA

来源 Source

来源生物 organism	Plasmodium falciparum Dd2
NCBI Class编号 ncbi_taxonomy_id	57267
宿主生物 host_organism	Spodoptera frugiperda

Entity 10 Entity 10 polymer

Description description	Proteasome subunit beta-3
Molecular weight formula_weight	24533.1 kDa
Source method src_method	man
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	J,X

MGSIYNYNGGCVLGMSGSNCVAIACDLRLGANTFTTVSTKFSKIFKMNNNVYVGLSGLATDIQTLYEILRYRVNLYEVRQDAEMDVECFANMLSSILYSNRFSPYFVNPIVVGFKLKHYVDEEGEKKVNYEPYLTAYDLIGAKCETRDFVVNGVTSEQLFGMCESLYVKDQDENGLFETISQCLLSALDRDCISGWGAEVLVLTPEKIIKKKLKARMD

来源 Source

来源生物 organism	Plasmodium falciparum Dd2
NCBI Class编号 ncbi_taxonomy_id	57267
宿主生物 host_organism	Spodoptera frugiperda

Entity 11 Entity 11 polymer

Description description	Proteasome subunit beta-4
Molecular weight formula_weight	22889.1 kDa
Source method src_method	man
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	K,Y

MDTLIGLRGNNFVVLAADTYSINSIIKLKNDDNTKFYDIHGNKCLLLGGSIGDRLQFGEFIRKNVHLYQYQNNTDMFVKSFAFFTRKNLAYYLRRNPFEVNCLIAGYDKKDGYQLYWCDYLSNMDSVNKGAHGYGAYLVSAILDKYYHENLTVDEALDIFKLCFEELKKRFLLTQINYELRIMYDNKVETQYVTV

来源 Source

来源生物 organism	Plasmodium falciparum Dd2
NCBI Class编号 ncbi_taxonomy_id	57267
宿主生物 host_organism	Spodoptera frugiperda

Entity 12 Entity 12 polymer

Description description	Proteasome subunit beta
Molecular weight formula_weight	23519.5 kDa
Source method src_method	man
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	L,Z

TTLAFKFKDGIIVAVDSRASMGSFISSQNVEKIIEINKNILGTMAGGAADCLYWEKYLGKIIKIYELRNNEKISVRAASTILSNILYQYKGYGLCCGIILSGYDHTGFNMFYVDDSGKKVEGNLFSCGSGSTYAYSILDSAYDYNLNLDQAVELARNAIYHATFRDGGSGGKVRVFHIHKNGYDKIIEGEDVFDLHYHYTNPEQKDQYVM

来源 Source

来源生物 organism	Plasmodium falciparum Dd2
NCBI Class编号 ncbi_taxonomy_id	57267
宿主生物 host_organism	Spodoptera frugiperda

Entity 13 Entity 13 polymer

Description description	Proteasome subunit beta
Molecular weight formula_weight	27301.2 kDa
Source method src_method	man
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	M,a

MDLILYNDNLTEKKTEKENVIEHGRGFKRWYPYIDNGGTVIGLTGKDYVILAADTRLSLSYSIYTRFCPKISKLTDKCIIGSSGMQSDIKTLHSLLQKKIQLFVLEHSHYPDIHVIARLLCVILYSRRFFPYYAFNILAGVDENNKGVLYNYDSVGSYCEATHSCVGSGSQLILPILDNRVEQKNQLIKNTNFNLGDDINFVKDAITSATERDIYTGDKTLIYVIDKMGINVNTLDLKQD

来源 Source

来源生物 organism	Plasmodium falciparum Dd2
NCBI Class编号 ncbi_taxonomy_id	57267
宿主生物 host_organism	Spodoptera frugiperda

Entity 14 Entity 14 polymer

Description description	Proteasome subunit beta
Molecular weight formula_weight	34823.0 kDa
Source method src_method	man
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	N,b

MTLGPVVTGTSVIAIKYKHGIMIAADRKASYGSYAKFQNVERIFKINNKTVMGFSGELADAQYLHELLTRKNINNLSEKKRKEDMYTPQHYHSYVSRVFYVRKNRIDPLFNNIIIAGINSQKYDNNDDNVLLYTNKNNDDEQNEYKNNEEYKEIHKDDLYIGFVDMHGTNFCDDYITTGYARYFALTLLRDHYKDNMTEEEARILINECLRILYFRDATSSNFIQIVKVTSKGVEYEEPYILPCVLNSADYVYPSTLLPPAGCMWENLYFQSSAWSHPQFEKGGGSGGGSGGSAWSHPQFEK

来源 Source

来源生物 organism	Plasmodium falciparum Dd2
NCBI Class编号 ncbi_taxonomy_id	57267
宿主生物 host_organism	Spodoptera frugiperda

Entity 15 Entity 15 non-polymer

Description description	;N,N-diethyl-N~2~-hexanoyl-D-asparaginyl-N-{(1S)-2-(2,4-difluorophenyl)-1-[(2S,3S,5S,6S)-5-formyl-2-hydroxy-3-(hydroxymethyl)-3,6-dimethylmorpholin-2-yl]ethyl}-4-fluoro-L-phenylalaninamide ;
Molecular weight formula_weight	777.9 kDa
Source method src_method	syn
Copy count entity_count	2

▶

8. Citations (1)

▶

Resolution resolution	3.00 Å
Resolution测定方法 resolution_method	—
颗粒数 num_particles	133662

fit	/app/data/saxs_computation/y0/9y0k/9y0k.fit
pddf	/app/data/pr_computation/y0/9y0k/9y0k.pr.out
profile	/app/data/saxs_computation/y0/9y0k/9y0k.dat

Structure of Plasmodium falciparum 20S proteasome with bound J80

1. Protein Identity and Related Structures Protein Identity & Related Structures

Proteasome subunit alpha type-6

State in the Current Structure

Other States of the Same Protein in the Database

Proteasome subunit alpha type-2

State in the Current Structure

Other States of the Same Protein in the Database

Proteasome subunit alpha type-3

State in the Current Structure

Other States of the Same Protein in the Database

Proteasome subunit alpha type-4

State in the Current Structure

Other States of the Same Protein in the Database

Proteasome subunit alpha type-5

State in the Current Structure

Other States of the Same Protein in the Database

Proteasome subunit alpha type-1

State in the Current Structure

Other States of the Same Protein in the Database

Proteasome subunit alpha type-3

State in the Current Structure

Other States of the Same Protein in the Database

Proteasome endopeptidase complex

State in the Current Structure

Other States of the Same Protein in the Database

Proteasome subunit beta-2

State in the Current Structure

Other States of the Same Protein in the Database

Proteasome subunit beta-3

State in the Current Structure

Other States of the Same Protein in the Database

Proteasome subunit beta-4

State in the Current Structure

Other States of the Same Protein in the Database

Proteasome subunit beta

State in the Current Structure

Other States of the Same Protein in the Database

Proteasome subunit beta

State in the Current Structure

Other States of the Same Protein in the Database

SAXS scattering curve SAXS Profile

P(r) Distance Distribution P(r) Distribution

2. Structure Basics 2. Structure Basics

3. SAXS Parameters (CRYSOL theoretical calculation) 3. SAXS Parameters (CRYSOL)

4. P(r) Distance Distribution (GNOM inversion) 4. P(r) Analysis (GNOM)

5. Crystallography and Experiment 5. Crystallography & Experiment

冷冻电镜 EM 3D

6. Entities and Polymers Entities & Polymers (15)

Entity 1 Entity 1 polymer

Polymer Polymer

来源 Source

Entity 2 Entity 2 polymer

Polymer Polymer

来源 Source

Entity 3 Entity 3 polymer

Polymer Polymer

来源 Source

Entity 4 Entity 4 polymer

Polymer Polymer

来源 Source

Entity 5 Entity 5 polymer

Polymer Polymer

来源 Source

Entity 6 Entity 6 polymer

Polymer Polymer

来源 Source

Entity 7 Entity 7 polymer

Polymer Polymer

来源 Source

Entity 8 Entity 8 polymer

Polymer Polymer

来源 Source

Entity 9 Entity 9 polymer

Polymer Polymer

来源 Source

Entity 10 Entity 10 polymer

Polymer Polymer

来源 Source

Entity 11 Entity 11 polymer