5fmg

Structure and function based design of Plasmodium-selective proteasome inhibitors

Method: ELECTRON MICROSCOPY

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1. Protein Identity and Related Structures Protein Identity & Related Structures

PROTEASOME SUBUNIT ALPHA, PUTATIVE

OrganismNot specified

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 28	PROTEASOME SUBUNIT ALPHA TYPE 2, PUTATIVE × 2 （C6KST3） PROTEASOME SUBUNIT ALPHA TYPE × 2 （Q8IDG3） PROTEASOME SUBUNIT ALPHA TYPE × 2 （Q8IDG2） PROTEASOME SUBUNIT ALPHA TYPE × 2 （Q8IBI3） PROTEOSOME SUBUNIT ALPHA TYPE 1, PUTATIVE × 2 （Q8IK90） PROTEASOME COMPONENT C8, PUTATIVE × 2 （O77396） PROTEASOME, PUTATIVE × 2 （Q8I0U7） PROTEASOME SUBUNIT BETA TYPE × 2 （Q8I6T3） BETA3 PROTEASOME SUBUNIT, PUTATIVE × 2 （Q8I261） PROTEASOME SUBUNIT BETA TYPE × 2 （Q8IKC9） PROTEASOME SUBUNIT BETA TYPE × 2 （Q8IJT1） PROTEASOME SUBUNIT BETA TYPE × 2 （C0H4E8） PROTEASOME SUBUNIT BETA TYPE × 2 （Q7K6A9） ;(2S)-N-[(E,2S)-1-(1H-indol-3-yl)-4-methylsulfonyl-but-3-en-2-yl]-2-[[(2S)-3-(1H-indol-3-yl)-2-(2-morpholin-4-ylethanoylamino)propanoyl]amino]-4-methyl-pentanamide ; × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	Q8IAR3_PLAF7
Isoform	—
PDB entities	1
Chains and sequence ranges	Author chain A； PDBConstruct 1–260； UniProt 1–260 Author chain O； PDBConstruct 1–260； UniProt 1–260

PROTEASOME SUBUNIT ALPHA TYPE 2, PUTATIVE

OrganismNot specified

UniProt C6KST3

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 28	PROTEASOME SUBUNIT ALPHA, PUTATIVE × 2 （Q8IAR3） PROTEASOME SUBUNIT ALPHA TYPE × 2 （Q8IDG3） PROTEASOME SUBUNIT ALPHA TYPE × 2 （Q8IDG2） PROTEASOME SUBUNIT ALPHA TYPE × 2 （Q8IBI3） PROTEOSOME SUBUNIT ALPHA TYPE 1, PUTATIVE × 2 （Q8IK90） PROTEASOME COMPONENT C8, PUTATIVE × 2 （O77396） PROTEASOME, PUTATIVE × 2 （Q8I0U7） PROTEASOME SUBUNIT BETA TYPE × 2 （Q8I6T3） BETA3 PROTEASOME SUBUNIT, PUTATIVE × 2 （Q8I261） PROTEASOME SUBUNIT BETA TYPE × 2 （Q8IKC9） PROTEASOME SUBUNIT BETA TYPE × 2 （Q8IJT1） PROTEASOME SUBUNIT BETA TYPE × 2 （C0H4E8） PROTEASOME SUBUNIT BETA TYPE × 2 （Q7K6A9） ;(2S)-N-[(E,2S)-1-(1H-indol-3-yl)-4-methylsulfonyl-but-3-en-2-yl]-2-[[(2S)-3-(1H-indol-3-yl)-2-(2-morpholin-4-ylethanoylamino)propanoyl]amino]-4-methyl-pentanamide ; × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	C6KST3_PLAF7
Isoform	—
PDB entities	2
Chains and sequence ranges	Author chain B； PDBConstruct 1–235； UniProt 1–235 Author chain P； PDBConstruct 1–235； UniProt 1–235

PROTEASOME SUBUNIT ALPHA TYPE

OrganismNot specified

UniProt Q8IDG3

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 28	PROTEASOME SUBUNIT ALPHA, PUTATIVE × 2 （Q8IAR3） PROTEASOME SUBUNIT ALPHA TYPE 2, PUTATIVE × 2 （C6KST3） PROTEASOME SUBUNIT ALPHA TYPE × 2 （Q8IDG2） PROTEASOME SUBUNIT ALPHA TYPE × 2 （Q8IBI3） PROTEOSOME SUBUNIT ALPHA TYPE 1, PUTATIVE × 2 （Q8IK90） PROTEASOME COMPONENT C8, PUTATIVE × 2 （O77396） PROTEASOME, PUTATIVE × 2 （Q8I0U7） PROTEASOME SUBUNIT BETA TYPE × 2 （Q8I6T3） BETA3 PROTEASOME SUBUNIT, PUTATIVE × 2 （Q8I261） PROTEASOME SUBUNIT BETA TYPE × 2 （Q8IKC9） PROTEASOME SUBUNIT BETA TYPE × 2 （Q8IJT1） PROTEASOME SUBUNIT BETA TYPE × 2 （C0H4E8） PROTEASOME SUBUNIT BETA TYPE × 2 （Q7K6A9） ;(2S)-N-[(E,2S)-1-(1H-indol-3-yl)-4-methylsulfonyl-but-3-en-2-yl]-2-[[(2S)-3-(1H-indol-3-yl)-2-(2-morpholin-4-ylethanoylamino)propanoyl]amino]-4-methyl-pentanamide ; × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	Q8IDG3_PLAF7
Isoform	—
PDB entities	3
Chains and sequence ranges	Author chain C； PDBConstruct 1–246； UniProt 1–246 Author chain Q； PDBConstruct 1–246； UniProt 1–246

PROTEASOME SUBUNIT ALPHA TYPE

OrganismNot specified

UniProt Q8IDG2

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 28	PROTEASOME SUBUNIT ALPHA, PUTATIVE × 2 （Q8IAR3） PROTEASOME SUBUNIT ALPHA TYPE 2, PUTATIVE × 2 （C6KST3） PROTEASOME SUBUNIT ALPHA TYPE × 2 （Q8IDG3） PROTEASOME SUBUNIT ALPHA TYPE × 2 （Q8IBI3） PROTEOSOME SUBUNIT ALPHA TYPE 1, PUTATIVE × 2 （Q8IK90） PROTEASOME COMPONENT C8, PUTATIVE × 2 （O77396） PROTEASOME, PUTATIVE × 2 （Q8I0U7） PROTEASOME SUBUNIT BETA TYPE × 2 （Q8I6T3） BETA3 PROTEASOME SUBUNIT, PUTATIVE × 2 （Q8I261） PROTEASOME SUBUNIT BETA TYPE × 2 （Q8IKC9） PROTEASOME SUBUNIT BETA TYPE × 2 （Q8IJT1） PROTEASOME SUBUNIT BETA TYPE × 2 （C0H4E8） PROTEASOME SUBUNIT BETA TYPE × 2 （Q7K6A9） ;(2S)-N-[(E,2S)-1-(1H-indol-3-yl)-4-methylsulfonyl-but-3-en-2-yl]-2-[[(2S)-3-(1H-indol-3-yl)-2-(2-morpholin-4-ylethanoylamino)propanoyl]amino]-4-methyl-pentanamide ; × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	Q8IDG2_PLAF7
Isoform	—
PDB entities	4
Chains and sequence ranges	Author chain D； PDBConstruct 1–241； UniProt 1–241 Author chain R； PDBConstruct 1–241； UniProt 1–241

PROTEASOME SUBUNIT ALPHA TYPE

OrganismNot specified

UniProt Q8IBI3

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 28	PROTEASOME SUBUNIT ALPHA, PUTATIVE × 2 （Q8IAR3） PROTEASOME SUBUNIT ALPHA TYPE 2, PUTATIVE × 2 （C6KST3） PROTEASOME SUBUNIT ALPHA TYPE × 2 （Q8IDG3） PROTEASOME SUBUNIT ALPHA TYPE × 2 （Q8IDG2） PROTEOSOME SUBUNIT ALPHA TYPE 1, PUTATIVE × 2 （Q8IK90） PROTEASOME COMPONENT C8, PUTATIVE × 2 （O77396） PROTEASOME, PUTATIVE × 2 （Q8I0U7） PROTEASOME SUBUNIT BETA TYPE × 2 （Q8I6T3） BETA3 PROTEASOME SUBUNIT, PUTATIVE × 2 （Q8I261） PROTEASOME SUBUNIT BETA TYPE × 2 （Q8IKC9） PROTEASOME SUBUNIT BETA TYPE × 2 （Q8IJT1） PROTEASOME SUBUNIT BETA TYPE × 2 （C0H4E8） PROTEASOME SUBUNIT BETA TYPE × 2 （Q7K6A9） ;(2S)-N-[(E,2S)-1-(1H-indol-3-yl)-4-methylsulfonyl-but-3-en-2-yl]-2-[[(2S)-3-(1H-indol-3-yl)-2-(2-morpholin-4-ylethanoylamino)propanoyl]amino]-4-methyl-pentanamide ; × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	Q8IBI3_PLAF7
Isoform	—
PDB entities	5
Chains and sequence ranges	Author chain E； PDBConstruct 1–256； UniProt 1–256 Author chain S； PDBConstruct 1–256； UniProt 1–256

PROTEOSOME SUBUNIT ALPHA TYPE 1, PUTATIVE

OrganismNot specified

UniProt Q8IK90

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 28	PROTEASOME SUBUNIT ALPHA, PUTATIVE × 2 （Q8IAR3） PROTEASOME SUBUNIT ALPHA TYPE 2, PUTATIVE × 2 （C6KST3） PROTEASOME SUBUNIT ALPHA TYPE × 2 （Q8IDG3） PROTEASOME SUBUNIT ALPHA TYPE × 2 （Q8IDG2） PROTEASOME SUBUNIT ALPHA TYPE × 2 （Q8IBI3） PROTEASOME COMPONENT C8, PUTATIVE × 2 （O77396） PROTEASOME, PUTATIVE × 2 （Q8I0U7） PROTEASOME SUBUNIT BETA TYPE × 2 （Q8I6T3） BETA3 PROTEASOME SUBUNIT, PUTATIVE × 2 （Q8I261） PROTEASOME SUBUNIT BETA TYPE × 2 （Q8IKC9） PROTEASOME SUBUNIT BETA TYPE × 2 （Q8IJT1） PROTEASOME SUBUNIT BETA TYPE × 2 （C0H4E8） PROTEASOME SUBUNIT BETA TYPE × 2 （Q7K6A9） ;(2S)-N-[(E,2S)-1-(1H-indol-3-yl)-4-methylsulfonyl-but-3-en-2-yl]-2-[[(2S)-3-(1H-indol-3-yl)-2-(2-morpholin-4-ylethanoylamino)propanoyl]amino]-4-methyl-pentanamide ; × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	Q8IK90_PLAF7
Isoform	—
PDB entities	6
Chains and sequence ranges	Author chain F； PDBConstruct 1–254； UniProt 1–254 Author chain T； PDBConstruct 1–254； UniProt 1–254

PROTEASOME COMPONENT C8, PUTATIVE

OrganismNot specified

UniProt O77396

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 28	PROTEASOME SUBUNIT ALPHA, PUTATIVE × 2 （Q8IAR3） PROTEASOME SUBUNIT ALPHA TYPE 2, PUTATIVE × 2 （C6KST3） PROTEASOME SUBUNIT ALPHA TYPE × 2 （Q8IDG3） PROTEASOME SUBUNIT ALPHA TYPE × 2 （Q8IDG2） PROTEASOME SUBUNIT ALPHA TYPE × 2 （Q8IBI3） PROTEOSOME SUBUNIT ALPHA TYPE 1, PUTATIVE × 2 （Q8IK90） PROTEASOME, PUTATIVE × 2 （Q8I0U7） PROTEASOME SUBUNIT BETA TYPE × 2 （Q8I6T3） BETA3 PROTEASOME SUBUNIT, PUTATIVE × 2 （Q8I261） PROTEASOME SUBUNIT BETA TYPE × 2 （Q8IKC9） PROTEASOME SUBUNIT BETA TYPE × 2 （Q8IJT1） PROTEASOME SUBUNIT BETA TYPE × 2 （C0H4E8） PROTEASOME SUBUNIT BETA TYPE × 2 （Q7K6A9） ;(2S)-N-[(E,2S)-1-(1H-indol-3-yl)-4-methylsulfonyl-but-3-en-2-yl]-2-[[(2S)-3-(1H-indol-3-yl)-2-(2-morpholin-4-ylethanoylamino)propanoyl]amino]-4-methyl-pentanamide ; × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	O77396_PLAF7
Isoform	—
PDB entities	7
Chains and sequence ranges	Author chain G； PDBConstruct 1–252； UniProt 1–252 Author chain U； PDBConstruct 1–252； UniProt 1–252

PROTEASOME, PUTATIVE

OrganismNot specified

UniProt Q8I0U7

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 28	PROTEASOME SUBUNIT ALPHA, PUTATIVE × 2 （Q8IAR3） PROTEASOME SUBUNIT ALPHA TYPE 2, PUTATIVE × 2 （C6KST3） PROTEASOME SUBUNIT ALPHA TYPE × 2 （Q8IDG3） PROTEASOME SUBUNIT ALPHA TYPE × 2 （Q8IDG2） PROTEASOME SUBUNIT ALPHA TYPE × 2 （Q8IBI3） PROTEOSOME SUBUNIT ALPHA TYPE 1, PUTATIVE × 2 （Q8IK90） PROTEASOME COMPONENT C8, PUTATIVE × 2 （O77396） PROTEASOME SUBUNIT BETA TYPE × 2 （Q8I6T3） BETA3 PROTEASOME SUBUNIT, PUTATIVE × 2 （Q8I261） PROTEASOME SUBUNIT BETA TYPE × 2 （Q8IKC9） PROTEASOME SUBUNIT BETA TYPE × 2 （Q8IJT1） PROTEASOME SUBUNIT BETA TYPE × 2 （C0H4E8） PROTEASOME SUBUNIT BETA TYPE × 2 （Q7K6A9） ;(2S)-N-[(E,2S)-1-(1H-indol-3-yl)-4-methylsulfonyl-but-3-en-2-yl]-2-[[(2S)-3-(1H-indol-3-yl)-2-(2-morpholin-4-ylethanoylamino)propanoyl]amino]-4-methyl-pentanamide ; × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	Q8I0U7_PLAF7
Isoform	—
PDB entities	8
Chains and sequence ranges	Author chain H； PDBConstruct 1–252； UniProt 31–282 Author chain V； PDBConstruct 1–252； UniProt 31–282

PROTEASOME SUBUNIT BETA TYPE

OrganismNot specified

UniProt Q8I6T3

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 28	PROTEASOME SUBUNIT ALPHA, PUTATIVE × 2 （Q8IAR3） PROTEASOME SUBUNIT ALPHA TYPE 2, PUTATIVE × 2 （C6KST3） PROTEASOME SUBUNIT ALPHA TYPE × 2 （Q8IDG3） PROTEASOME SUBUNIT ALPHA TYPE × 2 （Q8IDG2） PROTEASOME SUBUNIT ALPHA TYPE × 2 （Q8IBI3） PROTEOSOME SUBUNIT ALPHA TYPE 1, PUTATIVE × 2 （Q8IK90） PROTEASOME COMPONENT C8, PUTATIVE × 2 （O77396） PROTEASOME, PUTATIVE × 2 （Q8I0U7） BETA3 PROTEASOME SUBUNIT, PUTATIVE × 2 （Q8I261） PROTEASOME SUBUNIT BETA TYPE × 2 （Q8IKC9） PROTEASOME SUBUNIT BETA TYPE × 2 （Q8IJT1） PROTEASOME SUBUNIT BETA TYPE × 2 （C0H4E8） PROTEASOME SUBUNIT BETA TYPE × 2 （Q7K6A9） ;(2S)-N-[(E,2S)-1-(1H-indol-3-yl)-4-methylsulfonyl-but-3-en-2-yl]-2-[[(2S)-3-(1H-indol-3-yl)-2-(2-morpholin-4-ylethanoylamino)propanoyl]amino]-4-methyl-pentanamide ; × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	Q8I6T3_PLAF7
Isoform	—
PDB entities	9
Chains and sequence ranges	Author chain I； PDBConstruct 1–229； UniProt 42–270 Author chain W； PDBConstruct 1–229； UniProt 42–270

BETA3 PROTEASOME SUBUNIT, PUTATIVE

OrganismNot specified

UniProt Q8I261

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 28	PROTEASOME SUBUNIT ALPHA, PUTATIVE × 2 （Q8IAR3） PROTEASOME SUBUNIT ALPHA TYPE 2, PUTATIVE × 2 （C6KST3） PROTEASOME SUBUNIT ALPHA TYPE × 2 （Q8IDG3） PROTEASOME SUBUNIT ALPHA TYPE × 2 （Q8IDG2） PROTEASOME SUBUNIT ALPHA TYPE × 2 （Q8IBI3） PROTEOSOME SUBUNIT ALPHA TYPE 1, PUTATIVE × 2 （Q8IK90） PROTEASOME COMPONENT C8, PUTATIVE × 2 （O77396） PROTEASOME, PUTATIVE × 2 （Q8I0U7） PROTEASOME SUBUNIT BETA TYPE × 2 （Q8I6T3） PROTEASOME SUBUNIT BETA TYPE × 2 （Q8IKC9） PROTEASOME SUBUNIT BETA TYPE × 2 （Q8IJT1） PROTEASOME SUBUNIT BETA TYPE × 2 （C0H4E8） PROTEASOME SUBUNIT BETA TYPE × 2 （Q7K6A9） ;(2S)-N-[(E,2S)-1-(1H-indol-3-yl)-4-methylsulfonyl-but-3-en-2-yl]-2-[[(2S)-3-(1H-indol-3-yl)-2-(2-morpholin-4-ylethanoylamino)propanoyl]amino]-4-methyl-pentanamide ; × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	Q8I261_PLAF7
Isoform	—
PDB entities	10
Chains and sequence ranges	Author chain J； PDBConstruct 15–218； UniProt 1–204 Author chain X； PDBConstruct 15–218； UniProt 1–204

PROTEASOME SUBUNIT BETA TYPE

OrganismNot specified

UniProt Q8IKC9

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 28	PROTEASOME SUBUNIT ALPHA, PUTATIVE × 2 （Q8IAR3） PROTEASOME SUBUNIT ALPHA TYPE 2, PUTATIVE × 2 （C6KST3） PROTEASOME SUBUNIT ALPHA TYPE × 2 （Q8IDG3） PROTEASOME SUBUNIT ALPHA TYPE × 2 （Q8IDG2） PROTEASOME SUBUNIT ALPHA TYPE × 2 （Q8IBI3） PROTEOSOME SUBUNIT ALPHA TYPE 1, PUTATIVE × 2 （Q8IK90） PROTEASOME COMPONENT C8, PUTATIVE × 2 （O77396） PROTEASOME, PUTATIVE × 2 （Q8I0U7） PROTEASOME SUBUNIT BETA TYPE × 2 （Q8I6T3） BETA3 PROTEASOME SUBUNIT, PUTATIVE × 2 （Q8I261） PROTEASOME SUBUNIT BETA TYPE × 2 （Q8IJT1） PROTEASOME SUBUNIT BETA TYPE × 2 （C0H4E8） PROTEASOME SUBUNIT BETA TYPE × 2 （Q7K6A9） ;(2S)-N-[(E,2S)-1-(1H-indol-3-yl)-4-methylsulfonyl-but-3-en-2-yl]-2-[[(2S)-3-(1H-indol-3-yl)-2-(2-morpholin-4-ylethanoylamino)propanoyl]amino]-4-methyl-pentanamide ; × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	Q8IKC9_PLAF7
Isoform	—
PDB entities	11
Chains and sequence ranges	Author chain K； PDBConstruct 1–195； UniProt 1–195 Author chain Y； PDBConstruct 1–195； UniProt 1–195

PROTEASOME SUBUNIT BETA TYPE

OrganismNot specified

UniProt Q8IJT1

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 28	PROTEASOME SUBUNIT ALPHA, PUTATIVE × 2 （Q8IAR3） PROTEASOME SUBUNIT ALPHA TYPE 2, PUTATIVE × 2 （C6KST3） PROTEASOME SUBUNIT ALPHA TYPE × 2 （Q8IDG3） PROTEASOME SUBUNIT ALPHA TYPE × 2 （Q8IDG2） PROTEASOME SUBUNIT ALPHA TYPE × 2 （Q8IBI3） PROTEOSOME SUBUNIT ALPHA TYPE 1, PUTATIVE × 2 （Q8IK90） PROTEASOME COMPONENT C8, PUTATIVE × 2 （O77396） PROTEASOME, PUTATIVE × 2 （Q8I0U7） PROTEASOME SUBUNIT BETA TYPE × 2 （Q8I6T3） BETA3 PROTEASOME SUBUNIT, PUTATIVE × 2 （Q8I261） PROTEASOME SUBUNIT BETA TYPE × 2 （Q8IKC9） PROTEASOME SUBUNIT BETA TYPE × 2 （C0H4E8） PROTEASOME SUBUNIT BETA TYPE × 2 （Q7K6A9） ;(2S)-N-[(E,2S)-1-(1H-indol-3-yl)-4-methylsulfonyl-but-3-en-2-yl]-2-[[(2S)-3-(1H-indol-3-yl)-2-(2-morpholin-4-ylethanoylamino)propanoyl]amino]-4-methyl-pentanamide ; × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	Q8IJT1_PLAF7
Isoform	—
PDB entities	12
Chains and sequence ranges	Author chain L； PDBConstruct 1–211； UniProt 61–271 Author chain Z； PDBConstruct 1–211； UniProt 61–271

PROTEASOME SUBUNIT BETA TYPE

OrganismNot specified

UniProt C0H4E8

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 28	PROTEASOME SUBUNIT ALPHA, PUTATIVE × 2 （Q8IAR3） PROTEASOME SUBUNIT ALPHA TYPE 2, PUTATIVE × 2 （C6KST3） PROTEASOME SUBUNIT ALPHA TYPE × 2 （Q8IDG3） PROTEASOME SUBUNIT ALPHA TYPE × 2 （Q8IDG2） PROTEASOME SUBUNIT ALPHA TYPE × 2 （Q8IBI3） PROTEOSOME SUBUNIT ALPHA TYPE 1, PUTATIVE × 2 （Q8IK90） PROTEASOME COMPONENT C8, PUTATIVE × 2 （O77396） PROTEASOME, PUTATIVE × 2 （Q8I0U7） PROTEASOME SUBUNIT BETA TYPE × 2 （Q8I6T3） BETA3 PROTEASOME SUBUNIT, PUTATIVE × 2 （Q8I261） PROTEASOME SUBUNIT BETA TYPE × 2 （Q8IKC9） PROTEASOME SUBUNIT BETA TYPE × 2 （Q8IJT1） PROTEASOME SUBUNIT BETA TYPE × 2 （Q7K6A9） ;(2S)-N-[(E,2S)-1-(1H-indol-3-yl)-4-methylsulfonyl-but-3-en-2-yl]-2-[[(2S)-3-(1H-indol-3-yl)-2-(2-morpholin-4-ylethanoylamino)propanoyl]amino]-4-methyl-pentanamide ; × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	C0H4E8_PLAF7
Isoform	—
PDB entities	13
Chains and sequence ranges	Author chain M； PDBConstruct 1–240； UniProt 1–240 Author chain a； PDBConstruct 1–240； UniProt 1–240

PROTEASOME SUBUNIT BETA TYPE

OrganismNot specified

UniProt Q7K6A9

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 28	PROTEASOME SUBUNIT ALPHA, PUTATIVE × 2 （Q8IAR3） PROTEASOME SUBUNIT ALPHA TYPE 2, PUTATIVE × 2 （C6KST3） PROTEASOME SUBUNIT ALPHA TYPE × 2 （Q8IDG3） PROTEASOME SUBUNIT ALPHA TYPE × 2 （Q8IDG2） PROTEASOME SUBUNIT ALPHA TYPE × 2 （Q8IBI3） PROTEOSOME SUBUNIT ALPHA TYPE 1, PUTATIVE × 2 （Q8IK90） PROTEASOME COMPONENT C8, PUTATIVE × 2 （O77396） PROTEASOME, PUTATIVE × 2 （Q8I0U7） PROTEASOME SUBUNIT BETA TYPE × 2 （Q8I6T3） BETA3 PROTEASOME SUBUNIT, PUTATIVE × 2 （Q8I261） PROTEASOME SUBUNIT BETA TYPE × 2 （Q8IKC9） PROTEASOME SUBUNIT BETA TYPE × 2 （Q8IJT1） PROTEASOME SUBUNIT BETA TYPE × 2 （C0H4E8） ;(2S)-N-[(E,2S)-1-(1H-indol-3-yl)-4-methylsulfonyl-but-3-en-2-yl]-2-[[(2S)-3-(1H-indol-3-yl)-2-(2-morpholin-4-ylethanoylamino)propanoyl]amino]-4-methyl-pentanamide ; × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	Q7K6A9_PLAF7
Isoform	—
PDB entities	14
Chains and sequence ranges	Author chain N； PDBConstruct 1–265； UniProt 1–265 Author chain b； PDBConstruct 1–265； UniProt 1–265

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id	5fmg
Deposition date deposition_date	2015-11-04
Structure title title	Structure and function based design of Plasmodium-selective proteasome inhibitors
Keywords keywords	HYDROLASE, PROTEASOME, 20S, PLASMODIUM, MALARIA, INHIBITOR, DRUG DESIGN, CRYO-EM; HYDROLASE
Experimental Method method	ELECTRON MICROSCOPY

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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

5fmg__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

5fmg__assembly_1__model_1 | I(q)

100 plotted points; both axes use logarithmic scales.

5fmg__assembly_1__model_1 | P(r) · Pending

P(r) will be calculated and displayed separately for the same assembly/model.

Rg（Guinier）	58.96 Å
Rg (electron density)	58.60 Å
Total Rg	58.67 Å
Atom count	39334
Residues	5716
Excluded volume	697090 Å³
Maximum q	0.500 Å⁻¹

Assembly	Model	Structure unit	Oligomeric description	Status	CRYSOL	Actions
1	1	`5fmg__assembly_1__model_1`	28-meric （28）	Success	4.1.3-1-20251215 (887e7ef)	View Download

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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (15)

Entity 1 Entity 1 polymer

Description description	PROTEASOME SUBUNIT ALPHA, PUTATIVE
Molecular weight formula_weight	29531.7 kDa
EC 编号 ec_number	3.4.25.1
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	A,O
Atom count atom_count	39334

MVRPSQSMYDRHLTIFSPDGNLYQIEYAIKAVKNTNITSVGVKGENCAVIISQKKMATQYISQDKLLDYNNITNIYNITDEIGCSMVGMPGDCLSMVYKARSEASEFLYSNGYNVNAETLCRNICDKIQVYTQHAYMRLHACSGMIIGIDENNKPELFKFDPSGFCAGYRACVIGNKEQESISVLERLLEKRKKKIQQETIDEDIRNTTILAIEALQTILAFDLKASEIEVAIVSTKNRNFTQISEKEIDNYLTYIAERD

Entity 2 Entity 2 polymer

Description description	PROTEASOME SUBUNIT ALPHA TYPE 2, PUTATIVE
Molecular weight formula_weight	26556.4 kDa
EC 编号 ec_number	3.4.25.1
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	B,P

MADGEYSFSLTTFSPTGKLVQIEYALNRVSSSSPALGIRAKNGVIIATEKKSPNELIEENSIFKIQQISEHIGIVYAGMPGDFRVLLKRARKEAIRYSLQYGSEILVKELVKIIASIVQEFTQTGGVRPFGLSLLICGVDVYGYHLYQIDPSGCYFNWMATCVGKDYQNNMSFLEKRYNKDIEIEDAIHTAILTLKESYEGVLNEKNIEIGVAYDNKPFKILTQNEIKDYLIEIE

Entity 3 Entity 3 polymer

Description description	PROTEASOME SUBUNIT ALPHA TYPE
Molecular weight formula_weight	27977.7 kDa
EC 编号 ec_number	3.4.25.1
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	C,Q

MARRYDSRTTTFSPEGRLYQVEYALEAINNASITIGLITKDGVILGADKVFISKLIDKANNYEKIYKIDKHIFCGVAGLNADANILINQSRLYAQRYLYNYNEVQPVSQLVVQICDIKQSYTQYGGLRPYGVSFLIGGYDTKDGYQLYHTDPSGNYSGWFATAIGTNNLTASSVLKQEWKNDMTLEEGLLLALKTLAKSTDTEIPKSEKIELAYLTNKDGEVYQKYLTEKEIEELIKLYTQKYIKE

Entity 4 Entity 4 polymer

Description description	PROTEASOME SUBUNIT ALPHA TYPE
Molecular weight formula_weight	27263.3 kDa
EC 编号 ec_number	3.4.25.1
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	D,R

MSYDRAITVFSPDGHLLQVEHALEAVKKGGCAVAIKSSNFAVLAVEKKNIPKLQNPKTTEKLIKLDEHNCLAFAGLNADARVLVNKTRLECQRYYLNMDEPAPVDYIAKYVAKVQQKFTHRGGVRPFGIATLIAGFKNNKEICIYQTEPSGIYAAWKAQAIGKNAKIVQEFLEKNYQENMEQKDCIFLALKAIFEVVELSSKNVEVALLTEKDLTFIEEQEINSMVELIDQERTKNNEQNE

Entity 5 Entity 5 polymer

Description description	PROTEASOME SUBUNIT ALPHA TYPE
Molecular weight formula_weight	28417.4 kDa
EC 编号 ec_number	3.4.25.1
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	E,S

MFSTRSEYDRGVNTFSPEGRLFQVEYALGAIKLGSTAVGICVNDGVILASERRISSTLIEKDSVEKLLSIDDHIGCAMSGLMADARTLIDYARVECNHYKFIYNENINIKSCVELISELALDFSNLSDSKRKKIMSRPFGVALLIGGVDKNGPCLWYTEPSGTNTRFSAASIGSAQEGAELLLQENYKKDMTFEQAEILALTVLRQVMEDKLSTSNVEICAIKKSDQTFYKYNTDDISRIIDVLPSPVYPTIDMTA

Entity 6 Entity 6 polymer

Description description	PROTEOSOME SUBUNIT ALPHA TYPE 1, PUTATIVE
Molecular weight formula_weight	28871.7 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	F,T

MYRNLYDTDNIIYSPEGRLYQVEYASEAIKQGTCAVAIKSKDYVVVSGLKKCISKLSFPQEKIFKIDDYIGISMSGITSDAKVLTKFMQNECLSHKFLYNENINIESLVRSVADKYQKNTQKSSKRAFGVGLMIAAYHNEPCIFETRPNGSYFEYDALSFGARSHASKTYLEKNLHLFEECSLEELILHCLKALKCSLSSESELTISNTALAVVGKNHPWQEISSLQLEEYLSKVKMDAEQEQVEENVQNEANE

Entity 7 Entity 7 polymer

Description description	PROTEASOME COMPONENT C8, PUTATIVE
Molecular weight formula_weight	29324.3 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	G,U

MAGLSAGYDLSVSTFSPDGRLYQVEYIYKSINNNNTALCLECKDGIICCCINSNMDKNKMIKKNSYNRIYHVNNNIIITYSGFDGDARNIIDRARSEANTYYYNFHTNIPLHILVNRISLYIHAYTLYWHMRPFAASIIISSFNEKDKGDIYCIEPNGACYKYSGIVIGKNKEMFKTEIEKKDYKDINVRDAIEDIYKFILTSDDHMNKNNLQNLVNFSWICKESSYEFQNIHEEILTPALNKAVEYIEKLN

Entity 8 Entity 8 polymer

Description description	PROTEASOME, PUTATIVE
Molecular weight formula_weight	29143.9 kDa
EC 编号 ec_number	3.4.25.1
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	H,V

TTIIGIIYDNGVMLACDSRTSSGTFISNKCSRKINRINENLYVCRSGASAHSQKIIEIIKHYCVSMKNENRKKGRFHEGETIYDETTYDEEIDIDSINYLDYNNNNDNNLVTKNKYFYEDKFNDYNPLVENVAHITKKIIYTNNNFLSCALIFGGYDKIKKQQLYAVNLNGSIIEKHDFAVSGSGSIYIQSYLQDKYKKFMTKKECFNLILNCVKYAMHNDNSSGGLIRIVNITKSFVEEFTVVNTQMNFQY

Entity 9 Entity 9 polymer

Description description	PROTEASOME SUBUNIT BETA TYPE
Molecular weight formula_weight	25104.9 kDa
EC 编号 ec_number	3.4.25.1
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	I,W

TTICGLVCQNAVILGADTRATEGPIVADKNCSKLHYISKNIWCAGAGVAGDLEHTTLWLQHNVELHRLNTNTQPRVSMCVSRLTQELFKYQGYKVCAIVLGGVDVNGPQLYGIHPHGSSCLLPFTALGSGSLNAMAVLEAKYRDNMTIEEGKNLVCEAICAGIFNDLGSGGNVDICVITKDSYQHIRPYKEPNMRLYHLPHPTIYPKGTTPILSEKIEYIKKFISVEDA

Entity 10 Entity 10 polymer

Description description	BETA3 PROTEASOME SUBUNIT, PUTATIVE
Molecular weight formula_weight	24533.1 kDa
EC 编号 ec_number	3.4.25.1
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	J,X

MGSIYNYNGGCVLGMSGSNCVAIACDLRLGANTFTTVSTKFSKIFKMNNNVYVGLSGLATDIQTLYEILRYRVNLYEVRQDAEMDVECFANMLSSILYSNRFSPYFVNPIVVGFKLKHYVDEEGEKKVNYEPYLTAYDLIGAKCETRDFVVNGVTSEQLFGMCESLYVKDQDENGLFETISQCLLSALDRDCISGWGAEVLVLTPEKIIKKKLKARMD

Entity 11 Entity 11 polymer

Description description	PROTEASOME SUBUNIT BETA TYPE
Molecular weight formula_weight	22889.1 kDa
EC 编号 ec_number	3.4.25.1
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	K,Y

MDTLIGLRGNNFVVLAADTYSINSIIKLKNDDNTKFYDIHGNKCLLLGGSIGDRLQFGEFIRKNVHLYQYQNNTDMFVKSFAFFTRKNLAYYLRRNPFEVNCLIAGYDKKDGYQLYWCDYLSNMDSVNKGAHGYGAYLVSAILDKYYHENLTVDEALDIFKLCFEELKKRFLLTQINYELRIMYDNKVETQYVTV

Entity 12 Entity 12 polymer

Description description	PROTEASOME SUBUNIT BETA TYPE
Molecular weight formula_weight	23620.6 kDa
EC 编号 ec_number	3.4.25.1
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	L,Z

TTTLAFKFKDGIIVAVDSRASMGSFISSQNVEKIIEINKNILGTMAGGAADCLYWEKYLGKIIKIYELRNNEKISVRAASTILSNILYQYKGYGLCCGIILSGYDHTGFNMFYVDDSGKKVEGNLFSCGSGSTYAYSILDSAYDYNLNLDQAVELARNAIYHATFRDGGSGGKVRVFHIHKNGYDKIIEGEDVFDLHYHYTNPEQKDQYVM

Entity 13 Entity 13 polymer

Description description	PROTEASOME SUBUNIT BETA TYPE
Molecular weight formula_weight	27301.2 kDa
EC 编号 ec_number	3.4.25.1
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	M,a

MDLILYNDNLTEKKTEKENVIEHGRGFKRWYPYIDNGGTVIGLTGKDYVILAADTRLSLSYSIYTRFCPKISKLTDKCIIGSSGMQSDIKTLHSLLQKKIQLFVLEHSHYPDIHVIARLLCVILYSRRFFPYYAFNILAGVDENNKGVLYNYDSVGSYCEATHSCVGSGSQLILPILDNRVEQKNQLIKNTNFNLGDDINFVKDAITSATERDIYTGDKTLIYVIDKMGINVNTLDLKQD

Entity 14 Entity 14 polymer

Description description	PROTEASOME SUBUNIT BETA TYPE
Molecular weight formula_weight	30909.9 kDa
EC 编号 ec_number	3.4.25.1
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	N,b

MTLGPVVTGTSVIAIKYKHGIMIAADRKASYGSYAKFQNVERIFKINNKTVMGFSGELADAQYLHELLTRKNINNLSEKKRKEDMYTPQHYHSYVSRVFYVRKNRIDPLFNNIIIAGINSQKYDNNDDNVLLYTNKNNDDEQNEYKNNEEYKEIHKDDLYIGFVDMHGTNFCDDYITTGYARYFALTLLRDHYKDNMTEEEARILINECLRILYFRDATSSNFIQIVKVTSKGVEYEEPYILPCVLNSADYVYPSTLLPPAGCMW

Entity 15 Entity 15 non-polymer

Description description	;(2S)-N-[(E,2S)-1-(1H-indol-3-yl)-4-methylsulfonyl-but-3-en-2-yl]-2-[[(2S)-3-(1H-indol-3-yl)-2-(2-morpholin-4-ylethanoylamino)propanoyl]amino]-4-methyl-pentanamide ;
Molecular weight formula_weight	690.9 kDa
Source method src_method	syn
Copy count entity_count	2

▼

6. Fold Classification (SCOP + CATH) 28 domains

CATH v4.4 (28 domains)

Domain ID domain_id	5fmgA00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	5fmgB00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	5fmgC00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	5fmgD00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	5fmgE00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	5fmgF00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	5fmgG00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	5fmgH00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	5fmgI00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	5fmgJ00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	5fmgK00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	5fmgL00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	5fmgM00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	5fmgN00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	5fmgO00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	5fmgP00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	5fmgQ00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	5fmgR00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	5fmgS00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	5fmgT00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	5fmgU00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	5fmgV00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	5fmgW00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	5fmgX00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	5fmgY00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	5fmgZ00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	5fmga00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	5fmgb00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

▶

Unit-cell length a length_a	1.000 Å
Unit-cell length b length_b	1.000 Å
Unit-cell length c length_c	1.000 Å
Unit-cell angle α angle_alpha	90.00 °
Unit-cell angle β angle_beta	90.00 °
Unit-cell angle γ angle_gamma	90.00 °
Molecules per unit cell Z z_pdb	1

Space group space_group	P 1
Space-group number int_tables_number	1
Crystal system crystal_system	—

Resolution resolution	3.600 Å
Low-resolution limit resolution_low	— Å
R factor r_factor	—
R_work r_work	—
R_free r_free	—

Resolution resolution	3.60 Å
Resolution测定Method resolution_method	PROJECTION MATCHING
颗粒数 num_particles	97720

Structure and function based design of Plasmodium-selective proteasome inhibitors

1. Protein Identity and Related Structures Protein Identity & Related Structures

PROTEASOME SUBUNIT ALPHA, PUTATIVE

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

PROTEASOME SUBUNIT ALPHA TYPE 2, PUTATIVE

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

PROTEASOME SUBUNIT ALPHA TYPE

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

PROTEASOME SUBUNIT ALPHA TYPE

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

PROTEASOME SUBUNIT ALPHA TYPE

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

PROTEOSOME SUBUNIT ALPHA TYPE 1, PUTATIVE

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

PROTEASOME COMPONENT C8, PUTATIVE

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

PROTEASOME, PUTATIVE

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

PROTEASOME SUBUNIT BETA TYPE

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

BETA3 PROTEASOME SUBUNIT, PUTATIVE

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer