← Back to search
7lxu

Structure of Plasmodium falciparum 20S proteasome with bound MPI-5

Method: ELECTRON MICROSCOPY Dmax: 172.4 Å Quality: GOOD
▼

1. Protein Identity and Related Structures Protein Identity & Related Structures

20S proteasome alpha-1 subunit

OrganismNot specified

UniProt Q8IAR3

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 28 PDB declaration: 28-meric（28） Consistent with protein copy count Chain A； UniProt 1–260 Chain O； UniProt 1–260 Not recorded 20S proteasome alpha-2 subunit × 2 （C6KST3） 20S proteasome alpha-3 subunit × 2 （Q8IDG3） 20S proteasome alpha-4 subunit × 2 （Q8IDG2） 20S proteasome alpha-5 subunit × 2 （Q8IBI3） 20S proteasome alpha-6 subunit × 2 （Q8IK90） 20S proteasome alpha-7 subunit × 2 （O77396） 20S proteasome beta-1 subunit × 2 （Q8I0U7） 20S proteasome beta-2 subunit × 2 （Q8I6T3） 20S proteasome beta-3 subunit × 2 （Q8I261） 20S proteasome beta-4 subunit × 2 （Q8IKC9） 20S proteasome beta-5 subunit × 2 （Q8IJT1） 20S proteasome beta-6 subunit × 2 （A0A5K1K7U1） 20S proteasome beta-7 subunit × 2 （Q7K6A9） YHD N-[(1R)-2-([1,1'-biphenyl]-4-yl)-1-boronoethyl]-1-methyl-L-prolinamide × 2 ELECTRON MICROSCOPY cryo-EM buffer：pH 7.4 cryo-EM vitrification conditions：Cryogen ETHANE Resolution 3.10 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 7LXU Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
5FMG Structure and function based design of Plasmodium-selective proteasome inhibitors Deposited 2015-11-04 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain A 1–260（260 aa）
Chain O 1–260（260 aa）
Not recorded 7F1 (2S)-N-[(E,2S)-1-(1H-indol-3-yl)-4-methylsulfonyl-but-3-en-2-yl]-2-[[(2S)-3-(1H-indol-3-yl)-2-(2-morpholin-4-ylethanoylamino)propanoyl]amino]-4-methyl-pentanamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer 50MM TRIS HCL, 5MM MGCL2, 1MM DITHIOTREITOL；pH 7.5；50MM TRIS HCL, 5MM MGCL2, 1MM DITHIOTREITOL
cryo-EM vitrification conditions Cryogen ETHANE；VITRIFICATION 1 -- CRYOGEN- ETHANE, HUMIDITY- 95, INSTRUMENT- FEI VITROBOT MARK III, METHOD- BLOT 2.5 SECONDS BEFORE PLUNGING,
Resolution 3.60 Å
6MUV The structure of the Plasmodium falciparum 20S proteasome in complex with two PA28 activators Deposited 2018-10-23 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 42 PDB declaration: 42-meric
Chain A 1–260（260 aa）
Chain O 1–260（260 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE；wait time 0sec blot time 2sec blot force -1
Resolution 3.80 Å
6MUW The structure of the Plasmodium falciparum 20S proteasome. Deposited 2018-10-23 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain A 1–260（260 aa）
Chain O 1–260（260 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE；wait time 0sec blot time 2sec blot force -1
Resolution 3.60 Å
6MUX The structure of the Plasmodium falciparum 20S proteasome in complex with one PA28 activator Deposited 2018-10-23 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 35 PDB declaration: 35-meric
Chain A 1–260（260 aa）
Chain O 1–260（260 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE；wait time 0sec blot time 2sec blot force -1
Resolution 3.90 Å
7LXT Structure of Plasmodium falciparum 20S proteasome with bound bortezomib Deposited 2021-03-05 Different ligand/ion Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain A 1–260（260 aa）
Chain O 1–260（260 aa）
Not recorded BO2 N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE × 6 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.40 Å
8G6F Structure of the Plasmodium falciparum 20S proteasome beta-6 A117D mutant complexed with inhibitor WLW-vs Deposited 2023-02-15 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain A 1–260（260 aa）
Chain O 1–260（260 aa）
Not recorded 7F1 (2S)-N-[(E,2S)-1-(1H-indol-3-yl)-4-methylsulfonyl-but-3-en-2-yl]-2-[[(2S)-3-(1H-indol-3-yl)-2-(2-morpholin-4-ylethanoylamino)propanoyl]amino]-4-methyl-pentanamide × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.58 Å
8W2F Plasmodium falciparum 20S proteasome bound to an inhibitor Deposited 2024-02-20 Different ligand/ion Different experimental conditions Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain A 1–260（260 aa）
Chain O 1–260（260 aa）
Not recorded A1AE6 (3S)-1-[(2-fluoroethoxy)acetyl]-N-{[(4P)-4-(6-methylpyridin-3-yl)-1,3-thiazol-2-yl]methyl}piperidine-3-carboxamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
9O3E Plasmodium falciparum 20S proteasome bound to inhibitor 159 Deposited 2025-04-07 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain A 1–260（260 aa）
Chain O 1–260（260 aa）
Not recorded A1B74 (3S)-N~3~-{(1S)-1-[4-(4-cyanophenyl)-1,3-thiazol-2-yl]ethyl}-N~1~-ethoxypiperidine-1,3-dicarboxamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.79 Å
9O3F Plasmodium falciparum 20S proteasome bound to inhibitor 296 Deposited 2025-04-07 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain A 1–260（260 aa）
Chain O 1–260（260 aa）
Not recorded A1B73 (3S)-1-({[(3S)-piperidin-3-yl]oxy}acetyl)-N-({4-[4-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl}methyl)piperidine-3-carboxamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.28 Å
9Y0K Structure of Plasmodium falciparum 20S proteasome with bound J80 Deposited 2025-08-28 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain A 1–260（260 aa）
Chain O 1–260（260 aa）
Not recorded A1CRO N,N-diethyl-N~2~-hexanoyl-D-asparaginyl-N-{(1S)-2-(2,4-difluorophenyl)-1-[(2S,3S,5S,6S)-5-formyl-2-hydroxy-3-(hydroxymethyl)-3,6-dimethylmorpholin-2-yl]ethyl}-4-fluoro-L-phenylalaninamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.00 Å
9Y0L Incorrectly assembled half-Pf20S Deposited 2025-08-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 15 PDB declaration: pentadecameric
Chain A 1–260（260 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.00 Å
9Y1O The structure of the Plasmodium falciparum 20S proteasome Deposited 2025-08-29 Different ligand/ion Different experimental conditions Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain A 1–260（260 aa）
Chain O 1–260（260 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
9YUY Structure of the Plasmodium falciparum 20S proteasome in complex with a beta5-selective covalent syringolin analogue inhibitor. Deposited 2025-10-23 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain A 1–260（260 aa）
Chain O 1–260（260 aa）
Not recorded A1CY6 methyl N-{[(2R)-1-({(5R,8R)-5-[(3-fluorophenyl)methyl]-2,7-dioxo-1,6-diazacyclododecan-8-yl}amino)-1-oxo-3-phenylpropan-2-yl]carbamoyl}-L-valinate × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.70 Å

13 other PDB entries and 13 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name Q8IAR3_PLAF7
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–260； UniProt 1–260 Author chain O； PDBConstruct 1–260； UniProt 1–260

20S proteasome alpha-2 subunit

OrganismNot specified

UniProt C6KST3

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 28 PDB declaration: 28-meric（28） Consistent with protein copy count Chain B； UniProt 1–235 Chain P； UniProt 1–235 Not recorded 20S proteasome alpha-1 subunit × 2 （Q8IAR3） 20S proteasome alpha-3 subunit × 2 （Q8IDG3） 20S proteasome alpha-4 subunit × 2 （Q8IDG2） 20S proteasome alpha-5 subunit × 2 （Q8IBI3） 20S proteasome alpha-6 subunit × 2 （Q8IK90） 20S proteasome alpha-7 subunit × 2 （O77396） 20S proteasome beta-1 subunit × 2 （Q8I0U7） 20S proteasome beta-2 subunit × 2 （Q8I6T3） 20S proteasome beta-3 subunit × 2 （Q8I261） 20S proteasome beta-4 subunit × 2 （Q8IKC9） 20S proteasome beta-5 subunit × 2 （Q8IJT1） 20S proteasome beta-6 subunit × 2 （A0A5K1K7U1） 20S proteasome beta-7 subunit × 2 （Q7K6A9） YHD N-[(1R)-2-([1,1'-biphenyl]-4-yl)-1-boronoethyl]-1-methyl-L-prolinamide × 2 ELECTRON MICROSCOPY cryo-EM buffer：pH 7.4 cryo-EM vitrification conditions：Cryogen ETHANE Resolution 3.10 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 7LXU Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
5FMG Structure and function based design of Plasmodium-selective proteasome inhibitors Deposited 2015-11-04 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain B 1–235（235 aa）
Chain P 1–235（235 aa）
Not recorded 7F1 (2S)-N-[(E,2S)-1-(1H-indol-3-yl)-4-methylsulfonyl-but-3-en-2-yl]-2-[[(2S)-3-(1H-indol-3-yl)-2-(2-morpholin-4-ylethanoylamino)propanoyl]amino]-4-methyl-pentanamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer 50MM TRIS HCL, 5MM MGCL2, 1MM DITHIOTREITOL；pH 7.5；50MM TRIS HCL, 5MM MGCL2, 1MM DITHIOTREITOL
cryo-EM vitrification conditions Cryogen ETHANE；VITRIFICATION 1 -- CRYOGEN- ETHANE, HUMIDITY- 95, INSTRUMENT- FEI VITROBOT MARK III, METHOD- BLOT 2.5 SECONDS BEFORE PLUNGING,
Resolution 3.60 Å
6MUV The structure of the Plasmodium falciparum 20S proteasome in complex with two PA28 activators Deposited 2018-10-23 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 42 PDB declaration: 42-meric
Chain B 1–235（235 aa）
Chain P 1–235（235 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE；wait time 0sec blot time 2sec blot force -1
Resolution 3.80 Å
6MUW The structure of the Plasmodium falciparum 20S proteasome. Deposited 2018-10-23 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain B 1–235（235 aa）
Chain P 1–235（235 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE；wait time 0sec blot time 2sec blot force -1
Resolution 3.60 Å
6MUX The structure of the Plasmodium falciparum 20S proteasome in complex with one PA28 activator Deposited 2018-10-23 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 35 PDB declaration: 35-meric
Chain B 1–235（235 aa）
Chain P 1–235（235 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE；wait time 0sec blot time 2sec blot force -1
Resolution 3.90 Å
7LXT Structure of Plasmodium falciparum 20S proteasome with bound bortezomib Deposited 2021-03-05 Different ligand/ion Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain B 1–235（235 aa）
Chain P 1–235（235 aa）
Not recorded BO2 N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE × 6 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.40 Å
8G6F Structure of the Plasmodium falciparum 20S proteasome beta-6 A117D mutant complexed with inhibitor WLW-vs Deposited 2023-02-15 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain B 1–235（235 aa）
Chain P 1–235（235 aa）
Not recorded 7F1 (2S)-N-[(E,2S)-1-(1H-indol-3-yl)-4-methylsulfonyl-but-3-en-2-yl]-2-[[(2S)-3-(1H-indol-3-yl)-2-(2-morpholin-4-ylethanoylamino)propanoyl]amino]-4-methyl-pentanamide × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.58 Å
8W2F Plasmodium falciparum 20S proteasome bound to an inhibitor Deposited 2024-02-20 Different ligand/ion Different experimental conditions Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain B 1–235（235 aa）
Chain P 1–235（235 aa）
Not recorded A1AE6 (3S)-1-[(2-fluoroethoxy)acetyl]-N-{[(4P)-4-(6-methylpyridin-3-yl)-1,3-thiazol-2-yl]methyl}piperidine-3-carboxamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
9O3E Plasmodium falciparum 20S proteasome bound to inhibitor 159 Deposited 2025-04-07 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain B 1–235（235 aa）
Chain P 1–235（235 aa）
Not recorded A1B74 (3S)-N~3~-{(1S)-1-[4-(4-cyanophenyl)-1,3-thiazol-2-yl]ethyl}-N~1~-ethoxypiperidine-1,3-dicarboxamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.79 Å
9O3F Plasmodium falciparum 20S proteasome bound to inhibitor 296 Deposited 2025-04-07 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain B 1–235（235 aa）
Chain P 1–235（235 aa）
Not recorded A1B73 (3S)-1-({[(3S)-piperidin-3-yl]oxy}acetyl)-N-({4-[4-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl}methyl)piperidine-3-carboxamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.28 Å
9Y0K Structure of Plasmodium falciparum 20S proteasome with bound J80 Deposited 2025-08-28 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain B 1–235（235 aa）
Chain P 1–235（235 aa）
Not recorded A1CRO N,N-diethyl-N~2~-hexanoyl-D-asparaginyl-N-{(1S)-2-(2,4-difluorophenyl)-1-[(2S,3S,5S,6S)-5-formyl-2-hydroxy-3-(hydroxymethyl)-3,6-dimethylmorpholin-2-yl]ethyl}-4-fluoro-L-phenylalaninamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.00 Å
9Y0L Incorrectly assembled half-Pf20S Deposited 2025-08-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 15 PDB declaration: pentadecameric
Chain B 1–235（235 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.00 Å
9Y1O The structure of the Plasmodium falciparum 20S proteasome Deposited 2025-08-29 Different ligand/ion Different experimental conditions Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain B 1–235（235 aa）
Chain P 1–235（235 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
9YUY Structure of the Plasmodium falciparum 20S proteasome in complex with a beta5-selective covalent syringolin analogue inhibitor. Deposited 2025-10-23 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain B 1–235（235 aa）
Chain P 1–235（235 aa）
Not recorded A1CY6 methyl N-{[(2R)-1-({(5R,8R)-5-[(3-fluorophenyl)methyl]-2,7-dioxo-1,6-diazacyclododecan-8-yl}amino)-1-oxo-3-phenylpropan-2-yl]carbamoyl}-L-valinate × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.70 Å

13 other PDB entries and 13 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name C6KST3_PLAF7
Isoform —
PDB entities 2
Chains and sequence ranges Author chain B； PDBConstruct 1–235； UniProt 1–235 Author chain P； PDBConstruct 1–235； UniProt 1–235

20S proteasome alpha-3 subunit

OrganismNot specified

UniProt Q8IDG3

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 28 PDB declaration: 28-meric（28） Consistent with protein copy count Chain C； UniProt 1–246 Chain Q； UniProt 1–246 Not recorded 20S proteasome alpha-1 subunit × 2 （Q8IAR3） 20S proteasome alpha-2 subunit × 2 （C6KST3） 20S proteasome alpha-4 subunit × 2 （Q8IDG2） 20S proteasome alpha-5 subunit × 2 （Q8IBI3） 20S proteasome alpha-6 subunit × 2 （Q8IK90） 20S proteasome alpha-7 subunit × 2 （O77396） 20S proteasome beta-1 subunit × 2 （Q8I0U7） 20S proteasome beta-2 subunit × 2 （Q8I6T3） 20S proteasome beta-3 subunit × 2 （Q8I261） 20S proteasome beta-4 subunit × 2 （Q8IKC9） 20S proteasome beta-5 subunit × 2 （Q8IJT1） 20S proteasome beta-6 subunit × 2 （A0A5K1K7U1） 20S proteasome beta-7 subunit × 2 （Q7K6A9） YHD N-[(1R)-2-([1,1'-biphenyl]-4-yl)-1-boronoethyl]-1-methyl-L-prolinamide × 2 ELECTRON MICROSCOPY cryo-EM buffer：pH 7.4 cryo-EM vitrification conditions：Cryogen ETHANE Resolution 3.10 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 7LXU Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
5FMG Structure and function based design of Plasmodium-selective proteasome inhibitors Deposited 2015-11-04 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain C 1–246（246 aa）
Chain Q 1–246（246 aa）
Not recorded 7F1 (2S)-N-[(E,2S)-1-(1H-indol-3-yl)-4-methylsulfonyl-but-3-en-2-yl]-2-[[(2S)-3-(1H-indol-3-yl)-2-(2-morpholin-4-ylethanoylamino)propanoyl]amino]-4-methyl-pentanamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer 50MM TRIS HCL, 5MM MGCL2, 1MM DITHIOTREITOL；pH 7.5；50MM TRIS HCL, 5MM MGCL2, 1MM DITHIOTREITOL
cryo-EM vitrification conditions Cryogen ETHANE；VITRIFICATION 1 -- CRYOGEN- ETHANE, HUMIDITY- 95, INSTRUMENT- FEI VITROBOT MARK III, METHOD- BLOT 2.5 SECONDS BEFORE PLUNGING,
Resolution 3.60 Å
6MUV The structure of the Plasmodium falciparum 20S proteasome in complex with two PA28 activators Deposited 2018-10-23 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 42 PDB declaration: 42-meric
Chain C 1–246（246 aa）
Chain Q 1–246（246 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE；wait time 0sec blot time 2sec blot force -1
Resolution 3.80 Å
6MUW The structure of the Plasmodium falciparum 20S proteasome. Deposited 2018-10-23 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain C 1–246（246 aa）
Chain Q 1–246（246 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE；wait time 0sec blot time 2sec blot force -1
Resolution 3.60 Å
6MUX The structure of the Plasmodium falciparum 20S proteasome in complex with one PA28 activator Deposited 2018-10-23 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 35 PDB declaration: 35-meric
Chain C 1–246（246 aa）
Chain Q 1–246（246 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE；wait time 0sec blot time 2sec blot force -1
Resolution 3.90 Å
7LXT Structure of Plasmodium falciparum 20S proteasome with bound bortezomib Deposited 2021-03-05 Different ligand/ion Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain C 1–246（246 aa）
Chain Q 1–246（246 aa）
Not recorded BO2 N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE × 6 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.40 Å
8G6F Structure of the Plasmodium falciparum 20S proteasome beta-6 A117D mutant complexed with inhibitor WLW-vs Deposited 2023-02-15 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain C 1–246（246 aa）
Chain Q 1–246（246 aa）
Not recorded 7F1 (2S)-N-[(E,2S)-1-(1H-indol-3-yl)-4-methylsulfonyl-but-3-en-2-yl]-2-[[(2S)-3-(1H-indol-3-yl)-2-(2-morpholin-4-ylethanoylamino)propanoyl]amino]-4-methyl-pentanamide × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.58 Å
8W2F Plasmodium falciparum 20S proteasome bound to an inhibitor Deposited 2024-02-20 Different construct Different ligand/ion Different experimental conditions Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain C 1–242（242 aa）
Chain Q 1–242（242 aa）
Not recorded A1AE6 (3S)-1-[(2-fluoroethoxy)acetyl]-N-{[(4P)-4-(6-methylpyridin-3-yl)-1,3-thiazol-2-yl]methyl}piperidine-3-carboxamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
9O3E Plasmodium falciparum 20S proteasome bound to inhibitor 159 Deposited 2025-04-07 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain C 1–246（246 aa）
Chain Q 1–246（246 aa）
Not recorded A1B74 (3S)-N~3~-{(1S)-1-[4-(4-cyanophenyl)-1,3-thiazol-2-yl]ethyl}-N~1~-ethoxypiperidine-1,3-dicarboxamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.79 Å
9O3F Plasmodium falciparum 20S proteasome bound to inhibitor 296 Deposited 2025-04-07 Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain C 1–242（242 aa）
Chain Q 1–242（242 aa）
Not recorded A1B73 (3S)-1-({[(3S)-piperidin-3-yl]oxy}acetyl)-N-({4-[4-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl}methyl)piperidine-3-carboxamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.28 Å
9Y0K Structure of Plasmodium falciparum 20S proteasome with bound J80 Deposited 2025-08-28 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain C 1–246（246 aa）
Chain Q 1–246（246 aa）
Not recorded A1CRO N,N-diethyl-N~2~-hexanoyl-D-asparaginyl-N-{(1S)-2-(2,4-difluorophenyl)-1-[(2S,3S,5S,6S)-5-formyl-2-hydroxy-3-(hydroxymethyl)-3,6-dimethylmorpholin-2-yl]ethyl}-4-fluoro-L-phenylalaninamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.00 Å
9Y0L Incorrectly assembled half-Pf20S Deposited 2025-08-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 15 PDB declaration: pentadecameric
Chain C 1–246（246 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.00 Å
9Y1O The structure of the Plasmodium falciparum 20S proteasome Deposited 2025-08-29 Different ligand/ion Different experimental conditions Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain C 1–246（246 aa）
Chain Q 1–246（246 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
9YUY Structure of the Plasmodium falciparum 20S proteasome in complex with a beta5-selective covalent syringolin analogue inhibitor. Deposited 2025-10-23 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain C 1–246（246 aa）
Chain Q 1–246（246 aa）
Not recorded A1CY6 methyl N-{[(2R)-1-({(5R,8R)-5-[(3-fluorophenyl)methyl]-2,7-dioxo-1,6-diazacyclododecan-8-yl}amino)-1-oxo-3-phenylpropan-2-yl]carbamoyl}-L-valinate × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.70 Å

13 other PDB entries and 13 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name Q8IDG3_PLAF7
Isoform —
PDB entities 3
Chains and sequence ranges Author chain C； PDBConstruct 1–246； UniProt 1–246 Author chain Q； PDBConstruct 1–246； UniProt 1–246

20S proteasome alpha-4 subunit

OrganismNot specified

UniProt Q8IDG2

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 28 PDB declaration: 28-meric（28） Consistent with protein copy count Chain D； UniProt 1–241 Chain R； UniProt 1–241 Not recorded 20S proteasome alpha-1 subunit × 2 （Q8IAR3） 20S proteasome alpha-2 subunit × 2 （C6KST3） 20S proteasome alpha-3 subunit × 2 （Q8IDG3） 20S proteasome alpha-5 subunit × 2 （Q8IBI3） 20S proteasome alpha-6 subunit × 2 （Q8IK90） 20S proteasome alpha-7 subunit × 2 （O77396） 20S proteasome beta-1 subunit × 2 （Q8I0U7） 20S proteasome beta-2 subunit × 2 （Q8I6T3） 20S proteasome beta-3 subunit × 2 （Q8I261） 20S proteasome beta-4 subunit × 2 （Q8IKC9） 20S proteasome beta-5 subunit × 2 （Q8IJT1） 20S proteasome beta-6 subunit × 2 （A0A5K1K7U1） 20S proteasome beta-7 subunit × 2 （Q7K6A9） YHD N-[(1R)-2-([1,1'-biphenyl]-4-yl)-1-boronoethyl]-1-methyl-L-prolinamide × 2 ELECTRON MICROSCOPY cryo-EM buffer：pH 7.4 cryo-EM vitrification conditions：Cryogen ETHANE Resolution 3.10 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 7LXU Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
5FMG Structure and function based design of Plasmodium-selective proteasome inhibitors Deposited 2015-11-04 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain D 1–241（241 aa）
Chain R 1–241（241 aa）
Not recorded 7F1 (2S)-N-[(E,2S)-1-(1H-indol-3-yl)-4-methylsulfonyl-but-3-en-2-yl]-2-[[(2S)-3-(1H-indol-3-yl)-2-(2-morpholin-4-ylethanoylamino)propanoyl]amino]-4-methyl-pentanamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer 50MM TRIS HCL, 5MM MGCL2, 1MM DITHIOTREITOL；pH 7.5；50MM TRIS HCL, 5MM MGCL2, 1MM DITHIOTREITOL
cryo-EM vitrification conditions Cryogen ETHANE；VITRIFICATION 1 -- CRYOGEN- ETHANE, HUMIDITY- 95, INSTRUMENT- FEI VITROBOT MARK III, METHOD- BLOT 2.5 SECONDS BEFORE PLUNGING,
Resolution 3.60 Å
6MUV The structure of the Plasmodium falciparum 20S proteasome in complex with two PA28 activators Deposited 2018-10-23 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 42 PDB declaration: 42-meric
Chain D 1–241（241 aa）
Chain R 1–241（241 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE；wait time 0sec blot time 2sec blot force -1
Resolution 3.80 Å
6MUW The structure of the Plasmodium falciparum 20S proteasome. Deposited 2018-10-23 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain D 1–241（241 aa）
Chain R 1–241（241 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE；wait time 0sec blot time 2sec blot force -1
Resolution 3.60 Å
6MUX The structure of the Plasmodium falciparum 20S proteasome in complex with one PA28 activator Deposited 2018-10-23 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 35 PDB declaration: 35-meric
Chain D 1–241（241 aa）
Chain R 1–241（241 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE；wait time 0sec blot time 2sec blot force -1
Resolution 3.90 Å
7LXT Structure of Plasmodium falciparum 20S proteasome with bound bortezomib Deposited 2021-03-05 Different ligand/ion Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain D 1–241（241 aa）
Chain R 1–241（241 aa）
Not recorded BO2 N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE × 6 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.40 Å
8G6F Structure of the Plasmodium falciparum 20S proteasome beta-6 A117D mutant complexed with inhibitor WLW-vs Deposited 2023-02-15 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain D 1–241（241 aa）
Chain R 1–241（241 aa）
Not recorded 7F1 (2S)-N-[(E,2S)-1-(1H-indol-3-yl)-4-methylsulfonyl-but-3-en-2-yl]-2-[[(2S)-3-(1H-indol-3-yl)-2-(2-morpholin-4-ylethanoylamino)propanoyl]amino]-4-methyl-pentanamide × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.58 Å
8W2F Plasmodium falciparum 20S proteasome bound to an inhibitor Deposited 2024-02-20 Different ligand/ion Different experimental conditions Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain D 1–241（241 aa）
Chain R 1–241（241 aa）
Not recorded A1AE6 (3S)-1-[(2-fluoroethoxy)acetyl]-N-{[(4P)-4-(6-methylpyridin-3-yl)-1,3-thiazol-2-yl]methyl}piperidine-3-carboxamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
9O3E Plasmodium falciparum 20S proteasome bound to inhibitor 159 Deposited 2025-04-07 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain D 1–241（241 aa）
Chain R 1–241（241 aa）
Not recorded A1B74 (3S)-N~3~-{(1S)-1-[4-(4-cyanophenyl)-1,3-thiazol-2-yl]ethyl}-N~1~-ethoxypiperidine-1,3-dicarboxamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.79 Å
9O3F Plasmodium falciparum 20S proteasome bound to inhibitor 296 Deposited 2025-04-07 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain D 1–241（241 aa）
Chain R 1–241（241 aa）
Not recorded A1B73 (3S)-1-({[(3S)-piperidin-3-yl]oxy}acetyl)-N-({4-[4-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl}methyl)piperidine-3-carboxamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.28 Å
9Y0K Structure of Plasmodium falciparum 20S proteasome with bound J80 Deposited 2025-08-28 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain D 1–241（241 aa）
Chain R 1–241（241 aa）
Not recorded A1CRO N,N-diethyl-N~2~-hexanoyl-D-asparaginyl-N-{(1S)-2-(2,4-difluorophenyl)-1-[(2S,3S,5S,6S)-5-formyl-2-hydroxy-3-(hydroxymethyl)-3,6-dimethylmorpholin-2-yl]ethyl}-4-fluoro-L-phenylalaninamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.00 Å
9Y0L Incorrectly assembled half-Pf20S Deposited 2025-08-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 15 PDB declaration: pentadecameric
Chain D 1–241（241 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.00 Å
9Y1O The structure of the Plasmodium falciparum 20S proteasome Deposited 2025-08-29 Different ligand/ion Different experimental conditions Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain D 1–241（241 aa）
Chain R 1–241（241 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
9YUY Structure of the Plasmodium falciparum 20S proteasome in complex with a beta5-selective covalent syringolin analogue inhibitor. Deposited 2025-10-23 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain D 1–241（241 aa）
Chain R 1–241（241 aa）
Not recorded A1CY6 methyl N-{[(2R)-1-({(5R,8R)-5-[(3-fluorophenyl)methyl]-2,7-dioxo-1,6-diazacyclododecan-8-yl}amino)-1-oxo-3-phenylpropan-2-yl]carbamoyl}-L-valinate × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.70 Å

13 other PDB entries and 13 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name Q8IDG2_PLAF7
Isoform —
PDB entities 4
Chains and sequence ranges Author chain D； PDBConstruct 1–241； UniProt 1–241 Author chain R； PDBConstruct 1–241； UniProt 1–241

20S proteasome alpha-5 subunit

OrganismNot specified

UniProt Q8IBI3

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 28 PDB declaration: 28-meric（28） Consistent with protein copy count Chain E； UniProt 1–256 Chain S； UniProt 1–256 Not recorded 20S proteasome alpha-1 subunit × 2 （Q8IAR3） 20S proteasome alpha-2 subunit × 2 （C6KST3） 20S proteasome alpha-3 subunit × 2 （Q8IDG3） 20S proteasome alpha-4 subunit × 2 （Q8IDG2） 20S proteasome alpha-6 subunit × 2 （Q8IK90） 20S proteasome alpha-7 subunit × 2 （O77396） 20S proteasome beta-1 subunit × 2 （Q8I0U7） 20S proteasome beta-2 subunit × 2 （Q8I6T3） 20S proteasome beta-3 subunit × 2 （Q8I261） 20S proteasome beta-4 subunit × 2 （Q8IKC9） 20S proteasome beta-5 subunit × 2 （Q8IJT1） 20S proteasome beta-6 subunit × 2 （A0A5K1K7U1） 20S proteasome beta-7 subunit × 2 （Q7K6A9） YHD N-[(1R)-2-([1,1'-biphenyl]-4-yl)-1-boronoethyl]-1-methyl-L-prolinamide × 2 ELECTRON MICROSCOPY cryo-EM buffer：pH 7.4 cryo-EM vitrification conditions：Cryogen ETHANE Resolution 3.10 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 7LXU Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
5FMG Structure and function based design of Plasmodium-selective proteasome inhibitors Deposited 2015-11-04 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain E 1–256（256 aa）
Chain S 1–256（256 aa）
Not recorded 7F1 (2S)-N-[(E,2S)-1-(1H-indol-3-yl)-4-methylsulfonyl-but-3-en-2-yl]-2-[[(2S)-3-(1H-indol-3-yl)-2-(2-morpholin-4-ylethanoylamino)propanoyl]amino]-4-methyl-pentanamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer 50MM TRIS HCL, 5MM MGCL2, 1MM DITHIOTREITOL；pH 7.5；50MM TRIS HCL, 5MM MGCL2, 1MM DITHIOTREITOL
cryo-EM vitrification conditions Cryogen ETHANE；VITRIFICATION 1 -- CRYOGEN- ETHANE, HUMIDITY- 95, INSTRUMENT- FEI VITROBOT MARK III, METHOD- BLOT 2.5 SECONDS BEFORE PLUNGING,
Resolution 3.60 Å
6MUV The structure of the Plasmodium falciparum 20S proteasome in complex with two PA28 activators Deposited 2018-10-23 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 42 PDB declaration: 42-meric
Chain E 1–256（256 aa）
Chain S 1–256（256 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE；wait time 0sec blot time 2sec blot force -1
Resolution 3.80 Å
6MUW The structure of the Plasmodium falciparum 20S proteasome. Deposited 2018-10-23 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain E 1–256（256 aa）
Chain S 1–256（256 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE；wait time 0sec blot time 2sec blot force -1
Resolution 3.60 Å
6MUX The structure of the Plasmodium falciparum 20S proteasome in complex with one PA28 activator Deposited 2018-10-23 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 35 PDB declaration: 35-meric
Chain E 1–256（256 aa）
Chain S 1–256（256 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE；wait time 0sec blot time 2sec blot force -1
Resolution 3.90 Å
7LXT Structure of Plasmodium falciparum 20S proteasome with bound bortezomib Deposited 2021-03-05 Different ligand/ion Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain E 1–256（256 aa）
Chain S 1–256（256 aa）
Not recorded BO2 N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE × 6 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.40 Å
8W2F Plasmodium falciparum 20S proteasome bound to an inhibitor Deposited 2024-02-20 Different ligand/ion Different experimental conditions Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain E 1–256（256 aa）
Chain S 1–256（256 aa）
Not recorded A1AE6 (3S)-1-[(2-fluoroethoxy)acetyl]-N-{[(4P)-4-(6-methylpyridin-3-yl)-1,3-thiazol-2-yl]methyl}piperidine-3-carboxamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
9O3E Plasmodium falciparum 20S proteasome bound to inhibitor 159 Deposited 2025-04-07 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain E 1–256（256 aa）
Chain S 1–256（256 aa）
Not recorded A1B74 (3S)-N~3~-{(1S)-1-[4-(4-cyanophenyl)-1,3-thiazol-2-yl]ethyl}-N~1~-ethoxypiperidine-1,3-dicarboxamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.79 Å
9O3F Plasmodium falciparum 20S proteasome bound to inhibitor 296 Deposited 2025-04-07 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain E 1–256（256 aa）
Chain S 1–256（256 aa）
Not recorded A1B73 (3S)-1-({[(3S)-piperidin-3-yl]oxy}acetyl)-N-({4-[4-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl}methyl)piperidine-3-carboxamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.28 Å
9YUY Structure of the Plasmodium falciparum 20S proteasome in complex with a beta5-selective covalent syringolin analogue inhibitor. Deposited 2025-10-23 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain E 1–256（256 aa）
Chain S 1–256（256 aa）
Not recorded A1CY6 methyl N-{[(2R)-1-({(5R,8R)-5-[(3-fluorophenyl)methyl]-2,7-dioxo-1,6-diazacyclododecan-8-yl}amino)-1-oxo-3-phenylpropan-2-yl]carbamoyl}-L-valinate × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.70 Å

9 other PDB entries and 9 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name Q8IBI3_PLAF7
Isoform —
PDB entities 5
Chains and sequence ranges Author chain E； PDBConstruct 1–256； UniProt 1–256 Author chain S； PDBConstruct 1–256； UniProt 1–256

20S proteasome alpha-6 subunit

OrganismNot specified

UniProt Q8IK90

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 28 PDB declaration: 28-meric（28） Consistent with protein copy count Chain F； UniProt 1–254 Chain T； UniProt 1–254 Not recorded 20S proteasome alpha-1 subunit × 2 （Q8IAR3） 20S proteasome alpha-2 subunit × 2 （C6KST3） 20S proteasome alpha-3 subunit × 2 （Q8IDG3） 20S proteasome alpha-4 subunit × 2 （Q8IDG2） 20S proteasome alpha-5 subunit × 2 （Q8IBI3） 20S proteasome alpha-7 subunit × 2 （O77396） 20S proteasome beta-1 subunit × 2 （Q8I0U7） 20S proteasome beta-2 subunit × 2 （Q8I6T3） 20S proteasome beta-3 subunit × 2 （Q8I261） 20S proteasome beta-4 subunit × 2 （Q8IKC9） 20S proteasome beta-5 subunit × 2 （Q8IJT1） 20S proteasome beta-6 subunit × 2 （A0A5K1K7U1） 20S proteasome beta-7 subunit × 2 （Q7K6A9） YHD N-[(1R)-2-([1,1'-biphenyl]-4-yl)-1-boronoethyl]-1-methyl-L-prolinamide × 2 ELECTRON MICROSCOPY cryo-EM buffer：pH 7.4 cryo-EM vitrification conditions：Cryogen ETHANE Resolution 3.10 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 7LXU Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
5FMG Structure and function based design of Plasmodium-selective proteasome inhibitors Deposited 2015-11-04 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain F 1–254（254 aa）
Chain T 1–254（254 aa）
Not recorded 7F1 (2S)-N-[(E,2S)-1-(1H-indol-3-yl)-4-methylsulfonyl-but-3-en-2-yl]-2-[[(2S)-3-(1H-indol-3-yl)-2-(2-morpholin-4-ylethanoylamino)propanoyl]amino]-4-methyl-pentanamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer 50MM TRIS HCL, 5MM MGCL2, 1MM DITHIOTREITOL；pH 7.5；50MM TRIS HCL, 5MM MGCL2, 1MM DITHIOTREITOL
cryo-EM vitrification conditions Cryogen ETHANE；VITRIFICATION 1 -- CRYOGEN- ETHANE, HUMIDITY- 95, INSTRUMENT- FEI VITROBOT MARK III, METHOD- BLOT 2.5 SECONDS BEFORE PLUNGING,
Resolution 3.60 Å
6MUV The structure of the Plasmodium falciparum 20S proteasome in complex with two PA28 activators Deposited 2018-10-23 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 42 PDB declaration: 42-meric
Chain F 1–254（254 aa）
Chain T 1–254（254 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE；wait time 0sec blot time 2sec blot force -1
Resolution 3.80 Å
6MUW The structure of the Plasmodium falciparum 20S proteasome. Deposited 2018-10-23 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain F 1–254（254 aa）
Chain T 1–254（254 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE；wait time 0sec blot time 2sec blot force -1
Resolution 3.60 Å
6MUX The structure of the Plasmodium falciparum 20S proteasome in complex with one PA28 activator Deposited 2018-10-23 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 35 PDB declaration: 35-meric
Chain F 1–254（254 aa）
Chain T 1–254（254 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE；wait time 0sec blot time 2sec blot force -1
Resolution 3.90 Å
7LXT Structure of Plasmodium falciparum 20S proteasome with bound bortezomib Deposited 2021-03-05 Different ligand/ion Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain F 1–254（254 aa）
Chain T 1–254（254 aa）
Not recorded BO2 N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE × 6 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.40 Å
8G6F Structure of the Plasmodium falciparum 20S proteasome beta-6 A117D mutant complexed with inhibitor WLW-vs Deposited 2023-02-15 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain F 1–254（254 aa）
Chain T 1–254（254 aa）
Not recorded 7F1 (2S)-N-[(E,2S)-1-(1H-indol-3-yl)-4-methylsulfonyl-but-3-en-2-yl]-2-[[(2S)-3-(1H-indol-3-yl)-2-(2-morpholin-4-ylethanoylamino)propanoyl]amino]-4-methyl-pentanamide × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.58 Å
8W2F Plasmodium falciparum 20S proteasome bound to an inhibitor Deposited 2024-02-20 Different ligand/ion Different experimental conditions Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain F 1–254（254 aa）
Chain T 1–254（254 aa）
Not recorded A1AE6 (3S)-1-[(2-fluoroethoxy)acetyl]-N-{[(4P)-4-(6-methylpyridin-3-yl)-1,3-thiazol-2-yl]methyl}piperidine-3-carboxamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
9O3E Plasmodium falciparum 20S proteasome bound to inhibitor 159 Deposited 2025-04-07 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain F 1–254（254 aa）
Chain T 1–254（254 aa）
Not recorded A1B74 (3S)-N~3~-{(1S)-1-[4-(4-cyanophenyl)-1,3-thiazol-2-yl]ethyl}-N~1~-ethoxypiperidine-1,3-dicarboxamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.79 Å
9O3F Plasmodium falciparum 20S proteasome bound to inhibitor 296 Deposited 2025-04-07 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain F 1–254（254 aa）
Chain T 1–254（254 aa）
Not recorded A1B73 (3S)-1-({[(3S)-piperidin-3-yl]oxy}acetyl)-N-({4-[4-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl}methyl)piperidine-3-carboxamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.28 Å
9Y0K Structure of Plasmodium falciparum 20S proteasome with bound J80 Deposited 2025-08-28 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain F 1–254（254 aa）
Chain T 1–254（254 aa）
Not recorded A1CRO N,N-diethyl-N~2~-hexanoyl-D-asparaginyl-N-{(1S)-2-(2,4-difluorophenyl)-1-[(2S,3S,5S,6S)-5-formyl-2-hydroxy-3-(hydroxymethyl)-3,6-dimethylmorpholin-2-yl]ethyl}-4-fluoro-L-phenylalaninamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.00 Å
9Y0L Incorrectly assembled half-Pf20S Deposited 2025-08-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 15 PDB declaration: pentadecameric
Chain F 1–254（254 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.00 Å
9Y1O The structure of the Plasmodium falciparum 20S proteasome Deposited 2025-08-29 Different ligand/ion Different experimental conditions Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain F 1–254（254 aa）
Chain T 1–254（254 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
9YUY Structure of the Plasmodium falciparum 20S proteasome in complex with a beta5-selective covalent syringolin analogue inhibitor. Deposited 2025-10-23 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain F 1–254（254 aa）
Chain T 1–254（254 aa）
Not recorded A1CY6 methyl N-{[(2R)-1-({(5R,8R)-5-[(3-fluorophenyl)methyl]-2,7-dioxo-1,6-diazacyclododecan-8-yl}amino)-1-oxo-3-phenylpropan-2-yl]carbamoyl}-L-valinate × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.70 Å

13 other PDB entries and 13 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name Q8IK90_PLAF7
Isoform —
PDB entities 6
Chains and sequence ranges Author chain F； PDBConstruct 1–254； UniProt 1–254 Author chain T； PDBConstruct 1–254； UniProt 1–254

20S proteasome alpha-7 subunit

OrganismNot specified

UniProt O77396

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 28 PDB declaration: 28-meric（28） Consistent with protein copy count Chain G； UniProt 1–252 Chain U； UniProt 1–252 Not recorded 20S proteasome alpha-1 subunit × 2 （Q8IAR3） 20S proteasome alpha-2 subunit × 2 （C6KST3） 20S proteasome alpha-3 subunit × 2 （Q8IDG3） 20S proteasome alpha-4 subunit × 2 （Q8IDG2） 20S proteasome alpha-5 subunit × 2 （Q8IBI3） 20S proteasome alpha-6 subunit × 2 （Q8IK90） 20S proteasome beta-1 subunit × 2 （Q8I0U7） 20S proteasome beta-2 subunit × 2 （Q8I6T3） 20S proteasome beta-3 subunit × 2 （Q8I261） 20S proteasome beta-4 subunit × 2 （Q8IKC9） 20S proteasome beta-5 subunit × 2 （Q8IJT1） 20S proteasome beta-6 subunit × 2 （A0A5K1K7U1） 20S proteasome beta-7 subunit × 2 （Q7K6A9） YHD N-[(1R)-2-([1,1'-biphenyl]-4-yl)-1-boronoethyl]-1-methyl-L-prolinamide × 2 ELECTRON MICROSCOPY cryo-EM buffer：pH 7.4 cryo-EM vitrification conditions：Cryogen ETHANE Resolution 3.10 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 7LXU Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
5FMG Structure and function based design of Plasmodium-selective proteasome inhibitors Deposited 2015-11-04 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain G 1–252（252 aa）
Chain U 1–252（252 aa）
Not recorded 7F1 (2S)-N-[(E,2S)-1-(1H-indol-3-yl)-4-methylsulfonyl-but-3-en-2-yl]-2-[[(2S)-3-(1H-indol-3-yl)-2-(2-morpholin-4-ylethanoylamino)propanoyl]amino]-4-methyl-pentanamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer 50MM TRIS HCL, 5MM MGCL2, 1MM DITHIOTREITOL；pH 7.5；50MM TRIS HCL, 5MM MGCL2, 1MM DITHIOTREITOL
cryo-EM vitrification conditions Cryogen ETHANE；VITRIFICATION 1 -- CRYOGEN- ETHANE, HUMIDITY- 95, INSTRUMENT- FEI VITROBOT MARK III, METHOD- BLOT 2.5 SECONDS BEFORE PLUNGING,
Resolution 3.60 Å
6MUV The structure of the Plasmodium falciparum 20S proteasome in complex with two PA28 activators Deposited 2018-10-23 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 42 PDB declaration: 42-meric
Chain G 1–252（252 aa）
Chain U 1–252（252 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE；wait time 0sec blot time 2sec blot force -1
Resolution 3.80 Å
6MUW The structure of the Plasmodium falciparum 20S proteasome. Deposited 2018-10-23 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain G 1–252（252 aa）
Chain U 1–252（252 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE；wait time 0sec blot time 2sec blot force -1
Resolution 3.60 Å
6MUX The structure of the Plasmodium falciparum 20S proteasome in complex with one PA28 activator Deposited 2018-10-23 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 35 PDB declaration: 35-meric
Chain G 1–252（252 aa）
Chain U 1–252（252 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE；wait time 0sec blot time 2sec blot force -1
Resolution 3.90 Å
7LXT Structure of Plasmodium falciparum 20S proteasome with bound bortezomib Deposited 2021-03-05 Different ligand/ion Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain G 1–252（252 aa）
Chain U 1–252（252 aa）
Not recorded BO2 N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE × 6 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.40 Å
8G6F Structure of the Plasmodium falciparum 20S proteasome beta-6 A117D mutant complexed with inhibitor WLW-vs Deposited 2023-02-15 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain G 1–252（252 aa）
Chain U 1–252（252 aa）
Not recorded 7F1 (2S)-N-[(E,2S)-1-(1H-indol-3-yl)-4-methylsulfonyl-but-3-en-2-yl]-2-[[(2S)-3-(1H-indol-3-yl)-2-(2-morpholin-4-ylethanoylamino)propanoyl]amino]-4-methyl-pentanamide × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.58 Å
8W2F Plasmodium falciparum 20S proteasome bound to an inhibitor Deposited 2024-02-20 Different ligand/ion Different experimental conditions Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain G 1–252（252 aa）
Chain U 1–252（252 aa）
Not recorded A1AE6 (3S)-1-[(2-fluoroethoxy)acetyl]-N-{[(4P)-4-(6-methylpyridin-3-yl)-1,3-thiazol-2-yl]methyl}piperidine-3-carboxamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
9O3E Plasmodium falciparum 20S proteasome bound to inhibitor 159 Deposited 2025-04-07 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain G 1–252（252 aa）
Chain U 1–252（252 aa）
Not recorded A1B74 (3S)-N~3~-{(1S)-1-[4-(4-cyanophenyl)-1,3-thiazol-2-yl]ethyl}-N~1~-ethoxypiperidine-1,3-dicarboxamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.79 Å
9O3F Plasmodium falciparum 20S proteasome bound to inhibitor 296 Deposited 2025-04-07 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain G 1–252（252 aa）
Chain U 1–252（252 aa）
Not recorded A1B73 (3S)-1-({[(3S)-piperidin-3-yl]oxy}acetyl)-N-({4-[4-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl}methyl)piperidine-3-carboxamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.28 Å
9Y0K Structure of Plasmodium falciparum 20S proteasome with bound J80 Deposited 2025-08-28 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain G 1–252（252 aa）
Chain U 1–252（252 aa）
Not recorded A1CRO N,N-diethyl-N~2~-hexanoyl-D-asparaginyl-N-{(1S)-2-(2,4-difluorophenyl)-1-[(2S,3S,5S,6S)-5-formyl-2-hydroxy-3-(hydroxymethyl)-3,6-dimethylmorpholin-2-yl]ethyl}-4-fluoro-L-phenylalaninamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.00 Å
9Y0L Incorrectly assembled half-Pf20S Deposited 2025-08-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 15 PDB declaration: pentadecameric
Chain G 1–252（252 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.00 Å
9Y1O The structure of the Plasmodium falciparum 20S proteasome Deposited 2025-08-29 Different ligand/ion Different experimental conditions Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain G 1–252（252 aa）
Chain U 1–252（252 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
9YUY Structure of the Plasmodium falciparum 20S proteasome in complex with a beta5-selective covalent syringolin analogue inhibitor. Deposited 2025-10-23 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain G 1–252（252 aa）
Chain U 1–252（252 aa）
Not recorded A1CY6 methyl N-{[(2R)-1-({(5R,8R)-5-[(3-fluorophenyl)methyl]-2,7-dioxo-1,6-diazacyclododecan-8-yl}amino)-1-oxo-3-phenylpropan-2-yl]carbamoyl}-L-valinate × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.70 Å

13 other PDB entries and 13 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name O77396_PLAF7
Isoform —
PDB entities 7
Chains and sequence ranges Author chain G； PDBConstruct 1–252； UniProt 1–252 Author chain U； PDBConstruct 1–252； UniProt 1–252

20S proteasome beta-1 subunit

OrganismNot specified

UniProt Q8I0U7

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 28 PDB declaration: 28-meric（28） Consistent with protein copy count Chain H； UniProt 31–282 Chain V； UniProt 31–282 Not recorded 20S proteasome alpha-1 subunit × 2 （Q8IAR3） 20S proteasome alpha-2 subunit × 2 （C6KST3） 20S proteasome alpha-3 subunit × 2 （Q8IDG3） 20S proteasome alpha-4 subunit × 2 （Q8IDG2） 20S proteasome alpha-5 subunit × 2 （Q8IBI3） 20S proteasome alpha-6 subunit × 2 （Q8IK90） 20S proteasome alpha-7 subunit × 2 （O77396） 20S proteasome beta-2 subunit × 2 （Q8I6T3） 20S proteasome beta-3 subunit × 2 （Q8I261） 20S proteasome beta-4 subunit × 2 （Q8IKC9） 20S proteasome beta-5 subunit × 2 （Q8IJT1） 20S proteasome beta-6 subunit × 2 （A0A5K1K7U1） 20S proteasome beta-7 subunit × 2 （Q7K6A9） YHD N-[(1R)-2-([1,1'-biphenyl]-4-yl)-1-boronoethyl]-1-methyl-L-prolinamide × 2 ELECTRON MICROSCOPY cryo-EM buffer：pH 7.4 cryo-EM vitrification conditions：Cryogen ETHANE Resolution 3.10 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 7LXU Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
5FMG Structure and function based design of Plasmodium-selective proteasome inhibitors Deposited 2015-11-04 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain H 31–282（252 aa）
Chain V 31–282（252 aa）
Not recorded 7F1 (2S)-N-[(E,2S)-1-(1H-indol-3-yl)-4-methylsulfonyl-but-3-en-2-yl]-2-[[(2S)-3-(1H-indol-3-yl)-2-(2-morpholin-4-ylethanoylamino)propanoyl]amino]-4-methyl-pentanamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer 50MM TRIS HCL, 5MM MGCL2, 1MM DITHIOTREITOL；pH 7.5；50MM TRIS HCL, 5MM MGCL2, 1MM DITHIOTREITOL
cryo-EM vitrification conditions Cryogen ETHANE；VITRIFICATION 1 -- CRYOGEN- ETHANE, HUMIDITY- 95, INSTRUMENT- FEI VITROBOT MARK III, METHOD- BLOT 2.5 SECONDS BEFORE PLUNGING,
Resolution 3.60 Å
6MUV The structure of the Plasmodium falciparum 20S proteasome in complex with two PA28 activators Deposited 2018-10-23 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 42 PDB declaration: 42-meric
Chain H 31–282（252 aa）
Chain V 31–282（252 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE；wait time 0sec blot time 2sec blot force -1
Resolution 3.80 Å
6MUW The structure of the Plasmodium falciparum 20S proteasome. Deposited 2018-10-23 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain H 31–282（252 aa）
Chain V 31–282（252 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE；wait time 0sec blot time 2sec blot force -1
Resolution 3.60 Å
6MUX The structure of the Plasmodium falciparum 20S proteasome in complex with one PA28 activator Deposited 2018-10-23 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 35 PDB declaration: 35-meric
Chain H 31–282（252 aa）
Chain V 31–282（252 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE；wait time 0sec blot time 2sec blot force -1
Resolution 3.90 Å
7LXT Structure of Plasmodium falciparum 20S proteasome with bound bortezomib Deposited 2021-03-05 Different ligand/ion Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain H 31–282（252 aa）
Chain V 31–282（252 aa）
Not recorded BO2 N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE × 6 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.40 Å
8W2F Plasmodium falciparum 20S proteasome bound to an inhibitor Deposited 2024-02-20 Different ligand/ion Different experimental conditions Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain H 31–282（252 aa）
Chain V 31–282（252 aa）
Not recorded A1AE6 (3S)-1-[(2-fluoroethoxy)acetyl]-N-{[(4P)-4-(6-methylpyridin-3-yl)-1,3-thiazol-2-yl]methyl}piperidine-3-carboxamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
9O3E Plasmodium falciparum 20S proteasome bound to inhibitor 159 Deposited 2025-04-07 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain H 31–282（252 aa）
Chain V 31–282（252 aa）
Not recorded A1B74 (3S)-N~3~-{(1S)-1-[4-(4-cyanophenyl)-1,3-thiazol-2-yl]ethyl}-N~1~-ethoxypiperidine-1,3-dicarboxamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.79 Å
9O3F Plasmodium falciparum 20S proteasome bound to inhibitor 296 Deposited 2025-04-07 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain H 31–282（252 aa）
Chain V 31–282（252 aa）
Not recorded A1B73 (3S)-1-({[(3S)-piperidin-3-yl]oxy}acetyl)-N-({4-[4-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl}methyl)piperidine-3-carboxamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.28 Å
9YUY Structure of the Plasmodium falciparum 20S proteasome in complex with a beta5-selective covalent syringolin analogue inhibitor. Deposited 2025-10-23 Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain H 1–282（282 aa）
Chain V 1–282（282 aa）
Not recorded A1CY6 methyl N-{[(2R)-1-({(5R,8R)-5-[(3-fluorophenyl)methyl]-2,7-dioxo-1,6-diazacyclododecan-8-yl}amino)-1-oxo-3-phenylpropan-2-yl]carbamoyl}-L-valinate × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.70 Å

9 other PDB entries and 9 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name Q8I0U7_PLAF7
Isoform —
PDB entities 8
Chains and sequence ranges Author chain H； PDBConstruct 1–252； UniProt 31–282 Author chain V； PDBConstruct 1–252； UniProt 31–282

20S proteasome beta-2 subunit

OrganismNot specified

UniProt Q8I6T3

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 28 PDB declaration: 28-meric（28） Consistent with protein copy count Chain I； UniProt 42–270 Chain W； UniProt 42–270 Not recorded 20S proteasome alpha-1 subunit × 2 （Q8IAR3） 20S proteasome alpha-2 subunit × 2 （C6KST3） 20S proteasome alpha-3 subunit × 2 （Q8IDG3） 20S proteasome alpha-4 subunit × 2 （Q8IDG2） 20S proteasome alpha-5 subunit × 2 （Q8IBI3） 20S proteasome alpha-6 subunit × 2 （Q8IK90） 20S proteasome alpha-7 subunit × 2 （O77396） 20S proteasome beta-1 subunit × 2 （Q8I0U7） 20S proteasome beta-3 subunit × 2 （Q8I261） 20S proteasome beta-4 subunit × 2 （Q8IKC9） 20S proteasome beta-5 subunit × 2 （Q8IJT1） 20S proteasome beta-6 subunit × 2 （A0A5K1K7U1） 20S proteasome beta-7 subunit × 2 （Q7K6A9） YHD N-[(1R)-2-([1,1'-biphenyl]-4-yl)-1-boronoethyl]-1-methyl-L-prolinamide × 2 ELECTRON MICROSCOPY cryo-EM buffer：pH 7.4 cryo-EM vitrification conditions：Cryogen ETHANE Resolution 3.10 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 7LXU Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
5FMG Structure and function based design of Plasmodium-selective proteasome inhibitors Deposited 2015-11-04 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain I 42–270（229 aa）
Chain W 42–270（229 aa）
Not recorded 7F1 (2S)-N-[(E,2S)-1-(1H-indol-3-yl)-4-methylsulfonyl-but-3-en-2-yl]-2-[[(2S)-3-(1H-indol-3-yl)-2-(2-morpholin-4-ylethanoylamino)propanoyl]amino]-4-methyl-pentanamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer 50MM TRIS HCL, 5MM MGCL2, 1MM DITHIOTREITOL；pH 7.5；50MM TRIS HCL, 5MM MGCL2, 1MM DITHIOTREITOL
cryo-EM vitrification conditions Cryogen ETHANE；VITRIFICATION 1 -- CRYOGEN- ETHANE, HUMIDITY- 95, INSTRUMENT- FEI VITROBOT MARK III, METHOD- BLOT 2.5 SECONDS BEFORE PLUNGING,
Resolution 3.60 Å
6MUV The structure of the Plasmodium falciparum 20S proteasome in complex with two PA28 activators Deposited 2018-10-23 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 42 PDB declaration: 42-meric
Chain I 42–270（229 aa）
Chain W 42–270（229 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE；wait time 0sec blot time 2sec blot force -1
Resolution 3.80 Å
6MUW The structure of the Plasmodium falciparum 20S proteasome. Deposited 2018-10-23 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain I 42–270（229 aa）
Chain W 42–270（229 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE；wait time 0sec blot time 2sec blot force -1
Resolution 3.60 Å
6MUX The structure of the Plasmodium falciparum 20S proteasome in complex with one PA28 activator Deposited 2018-10-23 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 35 PDB declaration: 35-meric
Chain I 42–270（229 aa）
Chain W 42–270（229 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE；wait time 0sec blot time 2sec blot force -1
Resolution 3.90 Å
7LXT Structure of Plasmodium falciparum 20S proteasome with bound bortezomib Deposited 2021-03-05 Different ligand/ion Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain I 42–270（229 aa）
Chain W 42–270（229 aa）
Not recorded BO2 N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE × 6 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.40 Å
8G6F Structure of the Plasmodium falciparum 20S proteasome beta-6 A117D mutant complexed with inhibitor WLW-vs Deposited 2023-02-15 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain I 42–270（229 aa）
Chain W 42–270（229 aa）
Not recorded 7F1 (2S)-N-[(E,2S)-1-(1H-indol-3-yl)-4-methylsulfonyl-but-3-en-2-yl]-2-[[(2S)-3-(1H-indol-3-yl)-2-(2-morpholin-4-ylethanoylamino)propanoyl]amino]-4-methyl-pentanamide × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.58 Å
8W2F Plasmodium falciparum 20S proteasome bound to an inhibitor Deposited 2024-02-20 Different ligand/ion Different experimental conditions Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain I 42–270（229 aa）
Chain W 42–270（229 aa）
Not recorded A1AE6 (3S)-1-[(2-fluoroethoxy)acetyl]-N-{[(4P)-4-(6-methylpyridin-3-yl)-1,3-thiazol-2-yl]methyl}piperidine-3-carboxamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
9O3E Plasmodium falciparum 20S proteasome bound to inhibitor 159 Deposited 2025-04-07 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain I 42–270（229 aa）
Chain W 42–270（229 aa）
Not recorded A1B74 (3S)-N~3~-{(1S)-1-[4-(4-cyanophenyl)-1,3-thiazol-2-yl]ethyl}-N~1~-ethoxypiperidine-1,3-dicarboxamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.79 Å
9O3F Plasmodium falciparum 20S proteasome bound to inhibitor 296 Deposited 2025-04-07 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain I 42–270（229 aa）
Chain W 42–270（229 aa）
Not recorded A1B73 (3S)-1-({[(3S)-piperidin-3-yl]oxy}acetyl)-N-({4-[4-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl}methyl)piperidine-3-carboxamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.28 Å
9Y0K Structure of Plasmodium falciparum 20S proteasome with bound J80 Deposited 2025-08-28 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain I 42–270（229 aa）
Chain W 42–270（229 aa）
Not recorded A1CRO N,N-diethyl-N~2~-hexanoyl-D-asparaginyl-N-{(1S)-2-(2,4-difluorophenyl)-1-[(2S,3S,5S,6S)-5-formyl-2-hydroxy-3-(hydroxymethyl)-3,6-dimethylmorpholin-2-yl]ethyl}-4-fluoro-L-phenylalaninamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.00 Å
9Y1O The structure of the Plasmodium falciparum 20S proteasome Deposited 2025-08-29 Different ligand/ion Different experimental conditions Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain I 42–270（229 aa）
Chain W 42–270（229 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
9YUY Structure of the Plasmodium falciparum 20S proteasome in complex with a beta5-selective covalent syringolin analogue inhibitor. Deposited 2025-10-23 Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain I 1–270（270 aa）
Chain W 1–270（270 aa）
Not recorded A1CY6 methyl N-{[(2R)-1-({(5R,8R)-5-[(3-fluorophenyl)methyl]-2,7-dioxo-1,6-diazacyclododecan-8-yl}amino)-1-oxo-3-phenylpropan-2-yl]carbamoyl}-L-valinate × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.70 Å

12 other PDB entries and 12 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name Q8I6T3_PLAF7
Isoform —
PDB entities 9
Chains and sequence ranges Author chain I； PDBConstruct 1–229； UniProt 42–270 Author chain W； PDBConstruct 1–229； UniProt 42–270

20S proteasome beta-3 subunit

OrganismNot specified

UniProt Q8I261

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 28 PDB declaration: 28-meric（28） Consistent with protein copy count Chain J； UniProt 1–218 Chain X； UniProt 1–218 Not recorded 20S proteasome alpha-1 subunit × 2 （Q8IAR3） 20S proteasome alpha-2 subunit × 2 （C6KST3） 20S proteasome alpha-3 subunit × 2 （Q8IDG3） 20S proteasome alpha-4 subunit × 2 （Q8IDG2） 20S proteasome alpha-5 subunit × 2 （Q8IBI3） 20S proteasome alpha-6 subunit × 2 （Q8IK90） 20S proteasome alpha-7 subunit × 2 （O77396） 20S proteasome beta-1 subunit × 2 （Q8I0U7） 20S proteasome beta-2 subunit × 2 （Q8I6T3） 20S proteasome beta-4 subunit × 2 （Q8IKC9） 20S proteasome beta-5 subunit × 2 （Q8IJT1） 20S proteasome beta-6 subunit × 2 （A0A5K1K7U1） 20S proteasome beta-7 subunit × 2 （Q7K6A9） YHD N-[(1R)-2-([1,1'-biphenyl]-4-yl)-1-boronoethyl]-1-methyl-L-prolinamide × 2 ELECTRON MICROSCOPY cryo-EM buffer：pH 7.4 cryo-EM vitrification conditions：Cryogen ETHANE Resolution 3.10 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 7LXU Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
5FMG Structure and function based design of Plasmodium-selective proteasome inhibitors Deposited 2015-11-04 Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain J 1–204（204 aa）
Chain X 1–204（204 aa）
Not recorded 7F1 (2S)-N-[(E,2S)-1-(1H-indol-3-yl)-4-methylsulfonyl-but-3-en-2-yl]-2-[[(2S)-3-(1H-indol-3-yl)-2-(2-morpholin-4-ylethanoylamino)propanoyl]amino]-4-methyl-pentanamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer 50MM TRIS HCL, 5MM MGCL2, 1MM DITHIOTREITOL；pH 7.5；50MM TRIS HCL, 5MM MGCL2, 1MM DITHIOTREITOL
cryo-EM vitrification conditions Cryogen ETHANE；VITRIFICATION 1 -- CRYOGEN- ETHANE, HUMIDITY- 95, INSTRUMENT- FEI VITROBOT MARK III, METHOD- BLOT 2.5 SECONDS BEFORE PLUNGING,
Resolution 3.60 Å
6MUV The structure of the Plasmodium falciparum 20S proteasome in complex with two PA28 activators Deposited 2018-10-23 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 42 PDB declaration: 42-meric
Chain J 1–218（218 aa）
Chain X 1–218（218 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE；wait time 0sec blot time 2sec blot force -1
Resolution 3.80 Å
6MUW The structure of the Plasmodium falciparum 20S proteasome. Deposited 2018-10-23 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain J 1–218（218 aa）
Chain X 1–218（218 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE；wait time 0sec blot time 2sec blot force -1
Resolution 3.60 Å
6MUX The structure of the Plasmodium falciparum 20S proteasome in complex with one PA28 activator Deposited 2018-10-23 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 35 PDB declaration: 35-meric
Chain J 1–218（218 aa）
Chain X 1–218（218 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE；wait time 0sec blot time 2sec blot force -1
Resolution 3.90 Å
7LXT Structure of Plasmodium falciparum 20S proteasome with bound bortezomib Deposited 2021-03-05 Different ligand/ion Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain J 1–218（218 aa）
Chain X 1–218（218 aa）
Not recorded BO2 N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE × 6 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.40 Å
8G6F Structure of the Plasmodium falciparum 20S proteasome beta-6 A117D mutant complexed with inhibitor WLW-vs Deposited 2023-02-15 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain J 1–218（218 aa）
Chain X 1–218（218 aa）
Not recorded 7F1 (2S)-N-[(E,2S)-1-(1H-indol-3-yl)-4-methylsulfonyl-but-3-en-2-yl]-2-[[(2S)-3-(1H-indol-3-yl)-2-(2-morpholin-4-ylethanoylamino)propanoyl]amino]-4-methyl-pentanamide × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.58 Å
8W2F Plasmodium falciparum 20S proteasome bound to an inhibitor Deposited 2024-02-20 Different ligand/ion Different experimental conditions Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain J 1–218（218 aa）
Chain X 1–218（218 aa）
Not recorded A1AE6 (3S)-1-[(2-fluoroethoxy)acetyl]-N-{[(4P)-4-(6-methylpyridin-3-yl)-1,3-thiazol-2-yl]methyl}piperidine-3-carboxamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
9O3E Plasmodium falciparum 20S proteasome bound to inhibitor 159 Deposited 2025-04-07 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain J 1–218（218 aa）
Chain X 1–218（218 aa）
Not recorded A1B74 (3S)-N~3~-{(1S)-1-[4-(4-cyanophenyl)-1,3-thiazol-2-yl]ethyl}-N~1~-ethoxypiperidine-1,3-dicarboxamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.79 Å
9O3F Plasmodium falciparum 20S proteasome bound to inhibitor 296 Deposited 2025-04-07 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain J 1–218（218 aa）
Chain X 1–218（218 aa）
Not recorded A1B73 (3S)-1-({[(3S)-piperidin-3-yl]oxy}acetyl)-N-({4-[4-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl}methyl)piperidine-3-carboxamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.28 Å
9Y0K Structure of Plasmodium falciparum 20S proteasome with bound J80 Deposited 2025-08-28 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain J 1–218（218 aa）
Chain X 1–218（218 aa）
Not recorded A1CRO N,N-diethyl-N~2~-hexanoyl-D-asparaginyl-N-{(1S)-2-(2,4-difluorophenyl)-1-[(2S,3S,5S,6S)-5-formyl-2-hydroxy-3-(hydroxymethyl)-3,6-dimethylmorpholin-2-yl]ethyl}-4-fluoro-L-phenylalaninamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.00 Å
9Y0L Incorrectly assembled half-Pf20S Deposited 2025-08-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 15 PDB declaration: pentadecameric
Chain J 1–218（218 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.00 Å
9Y1O The structure of the Plasmodium falciparum 20S proteasome Deposited 2025-08-29 Different ligand/ion Different experimental conditions Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain J 1–218（218 aa）
Chain X 1–218（218 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
9YUY Structure of the Plasmodium falciparum 20S proteasome in complex with a beta5-selective covalent syringolin analogue inhibitor. Deposited 2025-10-23 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain J 1–218（218 aa）
Chain X 1–218（218 aa）
Not recorded A1CY6 methyl N-{[(2R)-1-({(5R,8R)-5-[(3-fluorophenyl)methyl]-2,7-dioxo-1,6-diazacyclododecan-8-yl}amino)-1-oxo-3-phenylpropan-2-yl]carbamoyl}-L-valinate × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.70 Å

13 other PDB entries and 13 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name Q8I261_PLAF7
Isoform —
PDB entities 10
Chains and sequence ranges Author chain J； PDBConstruct 1–218； UniProt 1–218 Author chain X； PDBConstruct 1–218； UniProt 1–218

20S proteasome beta-4 subunit

OrganismNot specified

UniProt Q8IKC9

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 28 PDB declaration: 28-meric（28） Consistent with protein copy count Chain K； UniProt 1–195 Chain Y； UniProt 1–195 Not recorded 20S proteasome alpha-1 subunit × 2 （Q8IAR3） 20S proteasome alpha-2 subunit × 2 （C6KST3） 20S proteasome alpha-3 subunit × 2 （Q8IDG3） 20S proteasome alpha-4 subunit × 2 （Q8IDG2） 20S proteasome alpha-5 subunit × 2 （Q8IBI3） 20S proteasome alpha-6 subunit × 2 （Q8IK90） 20S proteasome alpha-7 subunit × 2 （O77396） 20S proteasome beta-1 subunit × 2 （Q8I0U7） 20S proteasome beta-2 subunit × 2 （Q8I6T3） 20S proteasome beta-3 subunit × 2 （Q8I261） 20S proteasome beta-5 subunit × 2 （Q8IJT1） 20S proteasome beta-6 subunit × 2 （A0A5K1K7U1） 20S proteasome beta-7 subunit × 2 （Q7K6A9） YHD N-[(1R)-2-([1,1'-biphenyl]-4-yl)-1-boronoethyl]-1-methyl-L-prolinamide × 2 ELECTRON MICROSCOPY cryo-EM buffer：pH 7.4 cryo-EM vitrification conditions：Cryogen ETHANE Resolution 3.10 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 7LXU Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
5FMG Structure and function based design of Plasmodium-selective proteasome inhibitors Deposited 2015-11-04 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain K 1–195（195 aa）
Chain Y 1–195（195 aa）
Not recorded 7F1 (2S)-N-[(E,2S)-1-(1H-indol-3-yl)-4-methylsulfonyl-but-3-en-2-yl]-2-[[(2S)-3-(1H-indol-3-yl)-2-(2-morpholin-4-ylethanoylamino)propanoyl]amino]-4-methyl-pentanamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer 50MM TRIS HCL, 5MM MGCL2, 1MM DITHIOTREITOL；pH 7.5；50MM TRIS HCL, 5MM MGCL2, 1MM DITHIOTREITOL
cryo-EM vitrification conditions Cryogen ETHANE；VITRIFICATION 1 -- CRYOGEN- ETHANE, HUMIDITY- 95, INSTRUMENT- FEI VITROBOT MARK III, METHOD- BLOT 2.5 SECONDS BEFORE PLUNGING,
Resolution 3.60 Å
6MUV The structure of the Plasmodium falciparum 20S proteasome in complex with two PA28 activators Deposited 2018-10-23 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 42 PDB declaration: 42-meric
Chain K 1–195（195 aa）
Chain Y 1–195（195 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE；wait time 0sec blot time 2sec blot force -1
Resolution 3.80 Å
6MUW The structure of the Plasmodium falciparum 20S proteasome. Deposited 2018-10-23 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain K 1–195（195 aa）
Chain Y 1–195（195 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE；wait time 0sec blot time 2sec blot force -1
Resolution 3.60 Å
6MUX The structure of the Plasmodium falciparum 20S proteasome in complex with one PA28 activator Deposited 2018-10-23 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 35 PDB declaration: 35-meric
Chain K 1–195（195 aa）
Chain Y 1–195（195 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE；wait time 0sec blot time 2sec blot force -1
Resolution 3.90 Å
7LXT Structure of Plasmodium falciparum 20S proteasome with bound bortezomib Deposited 2021-03-05 Different ligand/ion Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain K 1–195（195 aa）
Chain Y 1–195（195 aa）
Not recorded BO2 N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE × 6 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.40 Å
8G6F Structure of the Plasmodium falciparum 20S proteasome beta-6 A117D mutant complexed with inhibitor WLW-vs Deposited 2023-02-15 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain K 1–195（195 aa）
Chain Y 1–195（195 aa）
Not recorded 7F1 (2S)-N-[(E,2S)-1-(1H-indol-3-yl)-4-methylsulfonyl-but-3-en-2-yl]-2-[[(2S)-3-(1H-indol-3-yl)-2-(2-morpholin-4-ylethanoylamino)propanoyl]amino]-4-methyl-pentanamide × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.58 Å
8W2F Plasmodium falciparum 20S proteasome bound to an inhibitor Deposited 2024-02-20 Different ligand/ion Different experimental conditions Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain K 1–195（195 aa）
Chain Y 1–195（195 aa）
Not recorded A1AE6 (3S)-1-[(2-fluoroethoxy)acetyl]-N-{[(4P)-4-(6-methylpyridin-3-yl)-1,3-thiazol-2-yl]methyl}piperidine-3-carboxamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
9O3E Plasmodium falciparum 20S proteasome bound to inhibitor 159 Deposited 2025-04-07 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain K 1–195（195 aa）
Chain Y 1–195（195 aa）
Not recorded A1B74 (3S)-N~3~-{(1S)-1-[4-(4-cyanophenyl)-1,3-thiazol-2-yl]ethyl}-N~1~-ethoxypiperidine-1,3-dicarboxamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.79 Å
9O3F Plasmodium falciparum 20S proteasome bound to inhibitor 296 Deposited 2025-04-07 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain K 1–195（195 aa）
Chain Y 1–195（195 aa）
Not recorded A1B73 (3S)-1-({[(3S)-piperidin-3-yl]oxy}acetyl)-N-({4-[4-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl}methyl)piperidine-3-carboxamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.28 Å
9Y0K Structure of Plasmodium falciparum 20S proteasome with bound J80 Deposited 2025-08-28 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain K 1–195（195 aa）
Chain Y 1–195（195 aa）
Not recorded A1CRO N,N-diethyl-N~2~-hexanoyl-D-asparaginyl-N-{(1S)-2-(2,4-difluorophenyl)-1-[(2S,3S,5S,6S)-5-formyl-2-hydroxy-3-(hydroxymethyl)-3,6-dimethylmorpholin-2-yl]ethyl}-4-fluoro-L-phenylalaninamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.00 Å
9Y0L Incorrectly assembled half-Pf20S Deposited 2025-08-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 15 PDB declaration: pentadecameric
Chain K 1–195（195 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.00 Å
9Y1O The structure of the Plasmodium falciparum 20S proteasome Deposited 2025-08-29 Different ligand/ion Different experimental conditions Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain K 1–195（195 aa）
Chain Y 1–195（195 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
9YUY Structure of the Plasmodium falciparum 20S proteasome in complex with a beta5-selective covalent syringolin analogue inhibitor. Deposited 2025-10-23 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain K 1–195（195 aa）
Chain Y 1–195（195 aa）
Not recorded A1CY6 methyl N-{[(2R)-1-({(5R,8R)-5-[(3-fluorophenyl)methyl]-2,7-dioxo-1,6-diazacyclododecan-8-yl}amino)-1-oxo-3-phenylpropan-2-yl]carbamoyl}-L-valinate × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.70 Å

13 other PDB entries and 13 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name Q8IKC9_PLAF7
Isoform —
PDB entities 11
Chains and sequence ranges Author chain K； PDBConstruct 1–195； UniProt 1–195 Author chain Y； PDBConstruct 1–195； UniProt 1–195

20S proteasome beta-5 subunit

OrganismNot specified

UniProt Q8IJT1

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 28 PDB declaration: 28-meric（28） Consistent with protein copy count Chain L； UniProt 61–271 Chain Z； UniProt 61–271 Not recorded 20S proteasome alpha-1 subunit × 2 （Q8IAR3） 20S proteasome alpha-2 subunit × 2 （C6KST3） 20S proteasome alpha-3 subunit × 2 （Q8IDG3） 20S proteasome alpha-4 subunit × 2 （Q8IDG2） 20S proteasome alpha-5 subunit × 2 （Q8IBI3） 20S proteasome alpha-6 subunit × 2 （Q8IK90） 20S proteasome alpha-7 subunit × 2 （O77396） 20S proteasome beta-1 subunit × 2 （Q8I0U7） 20S proteasome beta-2 subunit × 2 （Q8I6T3） 20S proteasome beta-3 subunit × 2 （Q8I261） 20S proteasome beta-4 subunit × 2 （Q8IKC9） 20S proteasome beta-6 subunit × 2 （A0A5K1K7U1） 20S proteasome beta-7 subunit × 2 （Q7K6A9） YHD N-[(1R)-2-([1,1'-biphenyl]-4-yl)-1-boronoethyl]-1-methyl-L-prolinamide × 2 ELECTRON MICROSCOPY cryo-EM buffer：pH 7.4 cryo-EM vitrification conditions：Cryogen ETHANE Resolution 3.10 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 7LXU Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
5FMG Structure and function based design of Plasmodium-selective proteasome inhibitors Deposited 2015-11-04 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain L 61–271（211 aa）
Chain Z 61–271（211 aa）
Not recorded 7F1 (2S)-N-[(E,2S)-1-(1H-indol-3-yl)-4-methylsulfonyl-but-3-en-2-yl]-2-[[(2S)-3-(1H-indol-3-yl)-2-(2-morpholin-4-ylethanoylamino)propanoyl]amino]-4-methyl-pentanamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer 50MM TRIS HCL, 5MM MGCL2, 1MM DITHIOTREITOL；pH 7.5；50MM TRIS HCL, 5MM MGCL2, 1MM DITHIOTREITOL
cryo-EM vitrification conditions Cryogen ETHANE；VITRIFICATION 1 -- CRYOGEN- ETHANE, HUMIDITY- 95, INSTRUMENT- FEI VITROBOT MARK III, METHOD- BLOT 2.5 SECONDS BEFORE PLUNGING,
Resolution 3.60 Å
6MUV The structure of the Plasmodium falciparum 20S proteasome in complex with two PA28 activators Deposited 2018-10-23 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 42 PDB declaration: 42-meric
Chain L 61–271（211 aa）
Chain Z 61–271（211 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE；wait time 0sec blot time 2sec blot force -1
Resolution 3.80 Å
6MUW The structure of the Plasmodium falciparum 20S proteasome. Deposited 2018-10-23 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain L 61–271（211 aa）
Chain Z 61–271（211 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE；wait time 0sec blot time 2sec blot force -1
Resolution 3.60 Å
6MUX The structure of the Plasmodium falciparum 20S proteasome in complex with one PA28 activator Deposited 2018-10-23 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 35 PDB declaration: 35-meric
Chain L 61–271（211 aa）
Chain Z 61–271（211 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE；wait time 0sec blot time 2sec blot force -1
Resolution 3.90 Å
7LXT Structure of Plasmodium falciparum 20S proteasome with bound bortezomib Deposited 2021-03-05 Different ligand/ion Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain L 61–271（211 aa）
Chain Z 61–271（211 aa）
Not recorded BO2 N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE × 6 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.40 Å
8G6F Structure of the Plasmodium falciparum 20S proteasome beta-6 A117D mutant complexed with inhibitor WLW-vs Deposited 2023-02-15 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain L 61–271（211 aa）
Chain Z 61–271（211 aa）
Not recorded 7F1 (2S)-N-[(E,2S)-1-(1H-indol-3-yl)-4-methylsulfonyl-but-3-en-2-yl]-2-[[(2S)-3-(1H-indol-3-yl)-2-(2-morpholin-4-ylethanoylamino)propanoyl]amino]-4-methyl-pentanamide × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.58 Å
8W2F Plasmodium falciparum 20S proteasome bound to an inhibitor Deposited 2024-02-20 Different ligand/ion Different experimental conditions Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain L 61–271（211 aa）
Chain Z 61–271（211 aa）
Not recorded A1AE6 (3S)-1-[(2-fluoroethoxy)acetyl]-N-{[(4P)-4-(6-methylpyridin-3-yl)-1,3-thiazol-2-yl]methyl}piperidine-3-carboxamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
9O3E Plasmodium falciparum 20S proteasome bound to inhibitor 159 Deposited 2025-04-07 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain L 61–271（211 aa）
Chain Z 61–271（211 aa）
Not recorded A1B74 (3S)-N~3~-{(1S)-1-[4-(4-cyanophenyl)-1,3-thiazol-2-yl]ethyl}-N~1~-ethoxypiperidine-1,3-dicarboxamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.79 Å
9O3F Plasmodium falciparum 20S proteasome bound to inhibitor 296 Deposited 2025-04-07 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain L 61–271（211 aa）
Chain Z 61–271（211 aa）
Not recorded A1B73 (3S)-1-({[(3S)-piperidin-3-yl]oxy}acetyl)-N-({4-[4-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl}methyl)piperidine-3-carboxamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.28 Å
9Y1O The structure of the Plasmodium falciparum 20S proteasome Deposited 2025-08-29 Different ligand/ion Different experimental conditions Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain L 61–271（211 aa）
Chain Z 61–271（211 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
9YUY Structure of the Plasmodium falciparum 20S proteasome in complex with a beta5-selective covalent syringolin analogue inhibitor. Deposited 2025-10-23 Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain L 1–271（271 aa）
Chain Z 1–271（271 aa）
Not recorded A1CY6 methyl N-{[(2R)-1-({(5R,8R)-5-[(3-fluorophenyl)methyl]-2,7-dioxo-1,6-diazacyclododecan-8-yl}amino)-1-oxo-3-phenylpropan-2-yl]carbamoyl}-L-valinate × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.70 Å

11 other PDB entries and 11 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name Q8IJT1_PLAF7
Isoform —
PDB entities 12
Chains and sequence ranges Author chain L； PDBConstruct 1–211； UniProt 61–271 Author chain Z； PDBConstruct 1–211； UniProt 61–271

20S proteasome beta-6 subunit

OrganismNot specified

UniProt A0A5K1K7U1

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 28 PDB declaration: 28-meric（28） Consistent with protein copy count Chain M； UniProt 1–240 Chain a； UniProt 1–240 Not recorded 20S proteasome alpha-1 subunit × 2 （Q8IAR3） 20S proteasome alpha-2 subunit × 2 （C6KST3） 20S proteasome alpha-3 subunit × 2 （Q8IDG3） 20S proteasome alpha-4 subunit × 2 （Q8IDG2） 20S proteasome alpha-5 subunit × 2 （Q8IBI3） 20S proteasome alpha-6 subunit × 2 （Q8IK90） 20S proteasome alpha-7 subunit × 2 （O77396） 20S proteasome beta-1 subunit × 2 （Q8I0U7） 20S proteasome beta-2 subunit × 2 （Q8I6T3） 20S proteasome beta-3 subunit × 2 （Q8I261） 20S proteasome beta-4 subunit × 2 （Q8IKC9） 20S proteasome beta-5 subunit × 2 （Q8IJT1） 20S proteasome beta-7 subunit × 2 （Q7K6A9） YHD N-[(1R)-2-([1,1'-biphenyl]-4-yl)-1-boronoethyl]-1-methyl-L-prolinamide × 2 ELECTRON MICROSCOPY cryo-EM buffer：pH 7.4 cryo-EM vitrification conditions：Cryogen ETHANE Resolution 3.10 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 7LXU Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
7LXT Structure of Plasmodium falciparum 20S proteasome with bound bortezomib Deposited 2021-03-05 Different ligand/ion Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain M 1–240（240 aa）
Chain a 1–240（240 aa）
Not recorded BO2 N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE × 6 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.40 Å
8W2F Plasmodium falciparum 20S proteasome bound to an inhibitor Deposited 2024-02-20 Different ligand/ion Different experimental conditions Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain M 1–240（240 aa）
Chain a 1–240（240 aa）
Not recorded A1AE6 (3S)-1-[(2-fluoroethoxy)acetyl]-N-{[(4P)-4-(6-methylpyridin-3-yl)-1,3-thiazol-2-yl]methyl}piperidine-3-carboxamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
9O3E Plasmodium falciparum 20S proteasome bound to inhibitor 159 Deposited 2025-04-07 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain M 1–240（240 aa）
Chain a 1–240（240 aa）
Not recorded A1B74 (3S)-N~3~-{(1S)-1-[4-(4-cyanophenyl)-1,3-thiazol-2-yl]ethyl}-N~1~-ethoxypiperidine-1,3-dicarboxamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.79 Å
9O3F Plasmodium falciparum 20S proteasome bound to inhibitor 296 Deposited 2025-04-07 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain M 1–240（240 aa）
Chain a 1–240（240 aa）
Not recorded A1B73 (3S)-1-({[(3S)-piperidin-3-yl]oxy}acetyl)-N-({4-[4-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl}methyl)piperidine-3-carboxamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.28 Å
9YUY Structure of the Plasmodium falciparum 20S proteasome in complex with a beta5-selective covalent syringolin analogue inhibitor. Deposited 2025-10-23 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain M 1–240（240 aa）
Chain a 1–240（240 aa）
Not recorded A1CY6 methyl N-{[(2R)-1-({(5R,8R)-5-[(3-fluorophenyl)methyl]-2,7-dioxo-1,6-diazacyclododecan-8-yl}amino)-1-oxo-3-phenylpropan-2-yl]carbamoyl}-L-valinate × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.70 Å

5 other PDB entries and 5 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name A0A5K1K7U1_PLAF7
Isoform —
PDB entities 13
Chains and sequence ranges Author chain M； PDBConstruct 1–240； UniProt 1–240 Author chain a； PDBConstruct 1–240； UniProt 1–240

20S proteasome beta-7 subunit

OrganismNot specified

UniProt Q7K6A9

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 28 PDB declaration: 28-meric（28） Consistent with protein copy count Chain N； UniProt 1–265 Chain b； UniProt 1–265 Not recorded 20S proteasome alpha-1 subunit × 2 （Q8IAR3） 20S proteasome alpha-2 subunit × 2 （C6KST3） 20S proteasome alpha-3 subunit × 2 （Q8IDG3） 20S proteasome alpha-4 subunit × 2 （Q8IDG2） 20S proteasome alpha-5 subunit × 2 （Q8IBI3） 20S proteasome alpha-6 subunit × 2 （Q8IK90） 20S proteasome alpha-7 subunit × 2 （O77396） 20S proteasome beta-1 subunit × 2 （Q8I0U7） 20S proteasome beta-2 subunit × 2 （Q8I6T3） 20S proteasome beta-3 subunit × 2 （Q8I261） 20S proteasome beta-4 subunit × 2 （Q8IKC9） 20S proteasome beta-5 subunit × 2 （Q8IJT1） 20S proteasome beta-6 subunit × 2 （A0A5K1K7U1） YHD N-[(1R)-2-([1,1'-biphenyl]-4-yl)-1-boronoethyl]-1-methyl-L-prolinamide × 2 ELECTRON MICROSCOPY cryo-EM buffer：pH 7.4 cryo-EM vitrification conditions：Cryogen ETHANE Resolution 3.10 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 7LXU Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
5FMG Structure and function based design of Plasmodium-selective proteasome inhibitors Deposited 2015-11-04 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain N 1–265（265 aa）
Chain b 1–265（265 aa）
Not recorded 7F1 (2S)-N-[(E,2S)-1-(1H-indol-3-yl)-4-methylsulfonyl-but-3-en-2-yl]-2-[[(2S)-3-(1H-indol-3-yl)-2-(2-morpholin-4-ylethanoylamino)propanoyl]amino]-4-methyl-pentanamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer 50MM TRIS HCL, 5MM MGCL2, 1MM DITHIOTREITOL；pH 7.5；50MM TRIS HCL, 5MM MGCL2, 1MM DITHIOTREITOL
cryo-EM vitrification conditions Cryogen ETHANE；VITRIFICATION 1 -- CRYOGEN- ETHANE, HUMIDITY- 95, INSTRUMENT- FEI VITROBOT MARK III, METHOD- BLOT 2.5 SECONDS BEFORE PLUNGING,
Resolution 3.60 Å
6MUV The structure of the Plasmodium falciparum 20S proteasome in complex with two PA28 activators Deposited 2018-10-23 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 42 PDB declaration: 42-meric
Chain N 1–265（265 aa）
Chain b 1–265（265 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE；wait time 0sec blot time 2sec blot force -1
Resolution 3.80 Å
6MUW The structure of the Plasmodium falciparum 20S proteasome. Deposited 2018-10-23 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain N 1–265（265 aa）
Chain b 1–265（265 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE；wait time 0sec blot time 2sec blot force -1
Resolution 3.60 Å
6MUX The structure of the Plasmodium falciparum 20S proteasome in complex with one PA28 activator Deposited 2018-10-23 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 35 PDB declaration: 35-meric
Chain N 1–265（265 aa）
Chain b 1–265（265 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE；wait time 0sec blot time 2sec blot force -1
Resolution 3.90 Å
7LXT Structure of Plasmodium falciparum 20S proteasome with bound bortezomib Deposited 2021-03-05 Different ligand/ion Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain N 1–265（265 aa）
Chain b 1–265（265 aa）
Not recorded BO2 N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE × 6 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.40 Å
8W2F Plasmodium falciparum 20S proteasome bound to an inhibitor Deposited 2024-02-20 Different ligand/ion Different experimental conditions Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain N 1–265（265 aa）
Chain b 1–265（265 aa）
Not recorded A1AE6 (3S)-1-[(2-fluoroethoxy)acetyl]-N-{[(4P)-4-(6-methylpyridin-3-yl)-1,3-thiazol-2-yl]methyl}piperidine-3-carboxamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
9YUY Structure of the Plasmodium falciparum 20S proteasome in complex with a beta5-selective covalent syringolin analogue inhibitor. Deposited 2025-10-23 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain N 1–265（265 aa）
Chain b 1–265（265 aa）
Not recorded A1CY6 methyl N-{[(2R)-1-({(5R,8R)-5-[(3-fluorophenyl)methyl]-2,7-dioxo-1,6-diazacyclododecan-8-yl}amino)-1-oxo-3-phenylpropan-2-yl]carbamoyl}-L-valinate × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.70 Å

7 other PDB entries and 7 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name Q7K6A9_PLAF7
Isoform —
PDB entities 14
Chains and sequence ranges Author chain N； PDBConstruct 1–265； UniProt 1–265 Author chain b； PDBConstruct 1–265； UniProt 1–265

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

SAXS scattering curve SAXS Profile

SAXS profile for 7lxu

P(r) Distance Distribution P(r) Distribution

P(r) distribution for 7lxu
Download Download
▼

2. Structure Basics 2. Structure Basics

Entry ID entry_id7lxu
Deposition date deposition_date2021-03-05
Structure title titleStructure of Plasmodium falciparum 20S proteasome with bound MPI-5
Keywords keywordsproteasome, plasmodium falciparum, malaria, drug, bortezomib, HYDROLASE; HYDROLASE
Experimental Method methodELECTRON MICROSCOPY
▼

3. SAXS Parameters (CRYSOL theoretical calculation) 3. SAXS Parameters (CRYSOL)

Radius of gyration Rg (Guinier) rg_guinier60.16 Å
Radius of gyration Rg (electron density) rg_electron59.72 Å
Forward intensity I(0) i07057560000.00
Molecular weight molecular_weight721970.0 kDa
Excluded volume excluded_volume907910 ų
Envelope volume envelope_volume1277700 ų
Hydration-shell volume shell_volume170710 ų
Envelope diameter envelope_diameter201.1 Å
Shell Rg shell_rg68.28 Å
Envelope Rg envelope_rg57.75 Å
Shape Rg shape_rg59.69 Å
Total Rg total_rg60.00 Å
Total atoms total_atoms50778
Residues n_residues6364
Spherical-harmonic order n_harmonics20
q range q_range— – 0.5000 Å−1
Data points n_points101
Shell type shell_typedirectional
Solvent electron density solvent_density0.3340 e/ų
Shell contrast contrast_shell0.0300 e/ų
CRYSOL version crysol_version4.1.3
▼

4. P(r) Distance Distribution (GNOM inversion) 4. P(r) Analysis (GNOM)

Maximum dimension Dmax dmax172.4 Å
Rg (real space) rg_real59.86 Å
Rg uncertainty (real space) rg_real_error0.97 Å
I(0) (real space) i0_real7.0580e+09
I(0) uncertainty (real space) i0_real_error1.2940e+08
Rg (reciprocal space) rg_reciprocal60.40 Å
I(0) (reciprocal space) i0_reciprocal7063000000.0000
Solution quality estimate total_estimate0.8345
Solution quality rating solution_quality GOOD a GOOD solution
P(r) peaks n_peaks2
Primary peak position r_peak_primary79.6 Å
Skewness Skewness skewness0.191
Kurtosis Kurtosis kurtosis-0.431
Angular range angular_range— – 0.1300 Å−1
Current regularization parameter α current_alpha0.0000
Highest regularization parameter α highest_alpha983600000.0000
Real-space data points n_real_points27
GNOM version gnom_version4.1.3
Quality Criteria quality_criteria AN1: 0.000; Oscil: 0.951; Stabil: 0.999; Sysdev: 1.000; Positv: 1.000; Valcen: 0.989; Smooth: 0.003
▶

5. Crystallography and Experiment 5. Crystallography & Experiment

▶

6. Entities and Polymers Entities & Polymers (15)

▼

7. Fold Classification (SCOP + CATH) 14 domains

CATH v4.4 (14 domains)

Domain ID domain_id7lxuA01
Class class3 — Alpha Beta
Architecture architecture60 — 4-Layer Sandwich
Topology topology20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain
Domain ID domain_id7lxuB01
Class class3 — Alpha Beta
Architecture architecture60 — 4-Layer Sandwich
Topology topology20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain
Domain ID domain_id7lxuC01
Class class3 — Alpha Beta
Architecture architecture60 — 4-Layer Sandwich
Topology topology20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain
Domain ID domain_id7lxuD01
Class class3 — Alpha Beta
Architecture architecture60 — 4-Layer Sandwich
Topology topology20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain
Domain ID domain_id7lxuE01
Class class3 — Alpha Beta
Architecture architecture60 — 4-Layer Sandwich
Topology topology20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain
Domain ID domain_id7lxuI01
Class class3 — Alpha Beta
Architecture architecture60 — 4-Layer Sandwich
Topology topology20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain
Domain ID domain_id7lxuL01
Class class3 — Alpha Beta
Architecture architecture60 — 4-Layer Sandwich
Topology topology20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain
Domain ID domain_id7lxuO01
Class class3 — Alpha Beta
Architecture architecture60 — 4-Layer Sandwich
Topology topology20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain
Domain ID domain_id7lxuP01
Class class3 — Alpha Beta
Architecture architecture60 — 4-Layer Sandwich
Topology topology20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain
Domain ID domain_id7lxuQ01
Class class3 — Alpha Beta
Architecture architecture60 — 4-Layer Sandwich
Topology topology20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain
Domain ID domain_id7lxuR01
Class class3 — Alpha Beta
Architecture architecture60 — 4-Layer Sandwich
Topology topology20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain
Domain ID domain_id7lxuS01
Class class3 — Alpha Beta
Architecture architecture60 — 4-Layer Sandwich
Topology topology20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain
Domain ID domain_id7lxuW01
Class class3 — Alpha Beta
Architecture architecture60 — 4-Layer Sandwich
Topology topology20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain
Domain ID domain_id7lxuZ01
Class class3 — Alpha Beta
Architecture architecture60 — 4-Layer Sandwich
Topology topology20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain
▶

8. Citations (1)

▶

9. Files and Curves (10)