9yuy

Structure of the Plasmodium falciparum 20S proteasome in complex with a beta5-selective covalent syringolin analogue inhibitor.

Method: ELECTRON MICROSCOPY

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1. Protein Identity and Related Structures Protein Identity & Related Structures

Proteasome subunit alpha type

Plasmodium falciparum 3D7

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 28	Proteasome subunit alpha type × 2 （Q8IDG2） Proteasome subunit alpha type × 2 （Q8IBI3） Proteasome endopeptidase complex × 2 （Q8IK90） Proteasome subunit alpha type-3, putative × 2 （O77396） Proteasome subunit beta × 2 （Q8IKC9） Proteasome subunit beta × 2 （Q8IJT1） Proteasome subunit beta × 2 （A0A5K1K7U1） Proteasome endopeptidase complex × 2 （Q8IAR3） Proteasome endopeptidase complex × 2 （C6KST3） Proteasome subunit beta type-6, putative × 2 （Q8I0U7） Proteasome subunit beta × 2 （Q8I6T3） Proteasome subunit beta × 2 （Q8I261） Proteasome subunit beta × 2 （Q7K6A9） ;methyl N-{[(2R)-1-({(5R,8R)-5-[(3-fluorophenyl)methyl]-2,7-dioxo-1,6-diazacyclododecan-8-yl}amino)-1-oxo-3-phenylpropan-2-yl]carbamoyl}-L-valinate ; × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	Q8IDG3_PLAF7
Isoform	—
PDB entities	1
Chains and sequence ranges	Author chain C； PDBConstruct 1–246； UniProt 1–246 Author chain Q； PDBConstruct 1–246； UniProt 1–246

Proteasome subunit alpha type

Plasmodium falciparum 3D7

UniProt Q8IDG2

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 28	Proteasome subunit alpha type × 2 （Q8IDG3） Proteasome subunit alpha type × 2 （Q8IBI3） Proteasome endopeptidase complex × 2 （Q8IK90） Proteasome subunit alpha type-3, putative × 2 （O77396） Proteasome subunit beta × 2 （Q8IKC9） Proteasome subunit beta × 2 （Q8IJT1） Proteasome subunit beta × 2 （A0A5K1K7U1） Proteasome endopeptidase complex × 2 （Q8IAR3） Proteasome endopeptidase complex × 2 （C6KST3） Proteasome subunit beta type-6, putative × 2 （Q8I0U7） Proteasome subunit beta × 2 （Q8I6T3） Proteasome subunit beta × 2 （Q8I261） Proteasome subunit beta × 2 （Q7K6A9） ;methyl N-{[(2R)-1-({(5R,8R)-5-[(3-fluorophenyl)methyl]-2,7-dioxo-1,6-diazacyclododecan-8-yl}amino)-1-oxo-3-phenylpropan-2-yl]carbamoyl}-L-valinate ; × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	Q8IDG2_PLAF7
Isoform	—
PDB entities	2
Chains and sequence ranges	Author chain D； PDBConstruct 1–241； UniProt 1–241 Author chain R； PDBConstruct 1–241； UniProt 1–241

Proteasome subunit alpha type

Plasmodium falciparum 3D7

UniProt Q8IBI3

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 28	Proteasome subunit alpha type × 2 （Q8IDG3） Proteasome subunit alpha type × 2 （Q8IDG2） Proteasome endopeptidase complex × 2 （Q8IK90） Proteasome subunit alpha type-3, putative × 2 （O77396） Proteasome subunit beta × 2 （Q8IKC9） Proteasome subunit beta × 2 （Q8IJT1） Proteasome subunit beta × 2 （A0A5K1K7U1） Proteasome endopeptidase complex × 2 （Q8IAR3） Proteasome endopeptidase complex × 2 （C6KST3） Proteasome subunit beta type-6, putative × 2 （Q8I0U7） Proteasome subunit beta × 2 （Q8I6T3） Proteasome subunit beta × 2 （Q8I261） Proteasome subunit beta × 2 （Q7K6A9） ;methyl N-{[(2R)-1-({(5R,8R)-5-[(3-fluorophenyl)methyl]-2,7-dioxo-1,6-diazacyclododecan-8-yl}amino)-1-oxo-3-phenylpropan-2-yl]carbamoyl}-L-valinate ; × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	Q8IBI3_PLAF7
Isoform	—
PDB entities	3
Chains and sequence ranges	Author chain E； PDBConstruct 1–256； UniProt 1–256 Author chain S； PDBConstruct 1–256； UniProt 1–256

Proteasome endopeptidase complex

Plasmodium falciparum 3D7

UniProt Q8IK90

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 28	Proteasome subunit alpha type × 2 （Q8IDG3） Proteasome subunit alpha type × 2 （Q8IDG2） Proteasome subunit alpha type × 2 （Q8IBI3） Proteasome subunit alpha type-3, putative × 2 （O77396） Proteasome subunit beta × 2 （Q8IKC9） Proteasome subunit beta × 2 （Q8IJT1） Proteasome subunit beta × 2 （A0A5K1K7U1） Proteasome endopeptidase complex × 2 （Q8IAR3） Proteasome endopeptidase complex × 2 （C6KST3） Proteasome subunit beta type-6, putative × 2 （Q8I0U7） Proteasome subunit beta × 2 （Q8I6T3） Proteasome subunit beta × 2 （Q8I261） Proteasome subunit beta × 2 （Q7K6A9） ;methyl N-{[(2R)-1-({(5R,8R)-5-[(3-fluorophenyl)methyl]-2,7-dioxo-1,6-diazacyclododecan-8-yl}amino)-1-oxo-3-phenylpropan-2-yl]carbamoyl}-L-valinate ; × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	Q8IK90_PLAF7
Isoform	—
PDB entities	4
Chains and sequence ranges	Author chain F； PDBConstruct 1–254； UniProt 1–254 Author chain T； PDBConstruct 1–254； UniProt 1–254

Proteasome subunit alpha type-3, putative

Plasmodium falciparum 3D7

UniProt O77396

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 28	Proteasome subunit alpha type × 2 （Q8IDG3） Proteasome subunit alpha type × 2 （Q8IDG2） Proteasome subunit alpha type × 2 （Q8IBI3） Proteasome endopeptidase complex × 2 （Q8IK90） Proteasome subunit beta × 2 （Q8IKC9） Proteasome subunit beta × 2 （Q8IJT1） Proteasome subunit beta × 2 （A0A5K1K7U1） Proteasome endopeptidase complex × 2 （Q8IAR3） Proteasome endopeptidase complex × 2 （C6KST3） Proteasome subunit beta type-6, putative × 2 （Q8I0U7） Proteasome subunit beta × 2 （Q8I6T3） Proteasome subunit beta × 2 （Q8I261） Proteasome subunit beta × 2 （Q7K6A9） ;methyl N-{[(2R)-1-({(5R,8R)-5-[(3-fluorophenyl)methyl]-2,7-dioxo-1,6-diazacyclododecan-8-yl}amino)-1-oxo-3-phenylpropan-2-yl]carbamoyl}-L-valinate ; × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	O77396_PLAF7
Isoform	—
PDB entities	5
Chains and sequence ranges	Author chain G； PDBConstruct 1–252； UniProt 1–252 Author chain U； PDBConstruct 1–252； UniProt 1–252

Proteasome subunit beta

Plasmodium falciparum 3D7

UniProt Q8IKC9

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 28	Proteasome subunit alpha type × 2 （Q8IDG3） Proteasome subunit alpha type × 2 （Q8IDG2） Proteasome subunit alpha type × 2 （Q8IBI3） Proteasome endopeptidase complex × 2 （Q8IK90） Proteasome subunit alpha type-3, putative × 2 （O77396） Proteasome subunit beta × 2 （Q8IJT1） Proteasome subunit beta × 2 （A0A5K1K7U1） Proteasome endopeptidase complex × 2 （Q8IAR3） Proteasome endopeptidase complex × 2 （C6KST3） Proteasome subunit beta type-6, putative × 2 （Q8I0U7） Proteasome subunit beta × 2 （Q8I6T3） Proteasome subunit beta × 2 （Q8I261） Proteasome subunit beta × 2 （Q7K6A9） ;methyl N-{[(2R)-1-({(5R,8R)-5-[(3-fluorophenyl)methyl]-2,7-dioxo-1,6-diazacyclododecan-8-yl}amino)-1-oxo-3-phenylpropan-2-yl]carbamoyl}-L-valinate ; × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	Q8IKC9_PLAF7
Isoform	—
PDB entities	6
Chains and sequence ranges	Author chain K； PDBConstruct 1–195； UniProt 1–195 Author chain Y； PDBConstruct 1–195； UniProt 1–195

Proteasome subunit beta

Plasmodium falciparum 3D7

UniProt Q8IJT1

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 28	Proteasome subunit alpha type × 2 （Q8IDG3） Proteasome subunit alpha type × 2 （Q8IDG2） Proteasome subunit alpha type × 2 （Q8IBI3） Proteasome endopeptidase complex × 2 （Q8IK90） Proteasome subunit alpha type-3, putative × 2 （O77396） Proteasome subunit beta × 2 （Q8IKC9） Proteasome subunit beta × 2 （A0A5K1K7U1） Proteasome endopeptidase complex × 2 （Q8IAR3） Proteasome endopeptidase complex × 2 （C6KST3） Proteasome subunit beta type-6, putative × 2 （Q8I0U7） Proteasome subunit beta × 2 （Q8I6T3） Proteasome subunit beta × 2 （Q8I261） Proteasome subunit beta × 2 （Q7K6A9） ;methyl N-{[(2R)-1-({(5R,8R)-5-[(3-fluorophenyl)methyl]-2,7-dioxo-1,6-diazacyclododecan-8-yl}amino)-1-oxo-3-phenylpropan-2-yl]carbamoyl}-L-valinate ; × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	Q8IJT1_PLAF7
Isoform	—
PDB entities	7
Chains and sequence ranges	Author chain L； PDBConstruct 1–271； UniProt 1–271 Author chain Z； PDBConstruct 1–271； UniProt 1–271

Proteasome subunit beta

Plasmodium falciparum 3D7

UniProt A0A5K1K7U1

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 28	Proteasome subunit alpha type × 2 （Q8IDG3） Proteasome subunit alpha type × 2 （Q8IDG2） Proteasome subunit alpha type × 2 （Q8IBI3） Proteasome endopeptidase complex × 2 （Q8IK90） Proteasome subunit alpha type-3, putative × 2 （O77396） Proteasome subunit beta × 2 （Q8IKC9） Proteasome subunit beta × 2 （Q8IJT1） Proteasome endopeptidase complex × 2 （Q8IAR3） Proteasome endopeptidase complex × 2 （C6KST3） Proteasome subunit beta type-6, putative × 2 （Q8I0U7） Proteasome subunit beta × 2 （Q8I6T3） Proteasome subunit beta × 2 （Q8I261） Proteasome subunit beta × 2 （Q7K6A9） ;methyl N-{[(2R)-1-({(5R,8R)-5-[(3-fluorophenyl)methyl]-2,7-dioxo-1,6-diazacyclododecan-8-yl}amino)-1-oxo-3-phenylpropan-2-yl]carbamoyl}-L-valinate ; × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	A0A5K1K7U1_PLAF7
Isoform	—
PDB entities	8
Chains and sequence ranges	Author chain M； PDBConstruct 1–240； UniProt 1–240 Author chain a； PDBConstruct 1–240； UniProt 1–240

Proteasome endopeptidase complex

Plasmodium falciparum 3D7

UniProt Q8IAR3

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 28	Proteasome subunit alpha type × 2 （Q8IDG3） Proteasome subunit alpha type × 2 （Q8IDG2） Proteasome subunit alpha type × 2 （Q8IBI3） Proteasome endopeptidase complex × 2 （Q8IK90） Proteasome subunit alpha type-3, putative × 2 （O77396） Proteasome subunit beta × 2 （Q8IKC9） Proteasome subunit beta × 2 （Q8IJT1） Proteasome subunit beta × 2 （A0A5K1K7U1） Proteasome endopeptidase complex × 2 （C6KST3） Proteasome subunit beta type-6, putative × 2 （Q8I0U7） Proteasome subunit beta × 2 （Q8I6T3） Proteasome subunit beta × 2 （Q8I261） Proteasome subunit beta × 2 （Q7K6A9） ;methyl N-{[(2R)-1-({(5R,8R)-5-[(3-fluorophenyl)methyl]-2,7-dioxo-1,6-diazacyclododecan-8-yl}amino)-1-oxo-3-phenylpropan-2-yl]carbamoyl}-L-valinate ; × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	Q8IAR3_PLAF7
Isoform	—
PDB entities	9
Chains and sequence ranges	Author chain A； PDBConstruct 1–260； UniProt 1–260 Author chain O； PDBConstruct 1–260； UniProt 1–260

Proteasome endopeptidase complex

Plasmodium falciparum 3D7

UniProt C6KST3

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 28	Proteasome subunit alpha type × 2 （Q8IDG3） Proteasome subunit alpha type × 2 （Q8IDG2） Proteasome subunit alpha type × 2 （Q8IBI3） Proteasome endopeptidase complex × 2 （Q8IK90） Proteasome subunit alpha type-3, putative × 2 （O77396） Proteasome subunit beta × 2 （Q8IKC9） Proteasome subunit beta × 2 （Q8IJT1） Proteasome subunit beta × 2 （A0A5K1K7U1） Proteasome endopeptidase complex × 2 （Q8IAR3） Proteasome subunit beta type-6, putative × 2 （Q8I0U7） Proteasome subunit beta × 2 （Q8I6T3） Proteasome subunit beta × 2 （Q8I261） Proteasome subunit beta × 2 （Q7K6A9） ;methyl N-{[(2R)-1-({(5R,8R)-5-[(3-fluorophenyl)methyl]-2,7-dioxo-1,6-diazacyclododecan-8-yl}amino)-1-oxo-3-phenylpropan-2-yl]carbamoyl}-L-valinate ; × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	C6KST3_PLAF7
Isoform	—
PDB entities	10
Chains and sequence ranges	Author chain B； PDBConstruct 1–235； UniProt 1–235 Author chain P； PDBConstruct 1–235； UniProt 1–235

Proteasome subunit beta type-6, putative

Plasmodium falciparum 3D7

UniProt Q8I0U7

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 28	Proteasome subunit alpha type × 2 （Q8IDG3） Proteasome subunit alpha type × 2 （Q8IDG2） Proteasome subunit alpha type × 2 （Q8IBI3） Proteasome endopeptidase complex × 2 （Q8IK90） Proteasome subunit alpha type-3, putative × 2 （O77396） Proteasome subunit beta × 2 （Q8IKC9） Proteasome subunit beta × 2 （Q8IJT1） Proteasome subunit beta × 2 （A0A5K1K7U1） Proteasome endopeptidase complex × 2 （Q8IAR3） Proteasome endopeptidase complex × 2 （C6KST3） Proteasome subunit beta × 2 （Q8I6T3） Proteasome subunit beta × 2 （Q8I261） Proteasome subunit beta × 2 （Q7K6A9） ;methyl N-{[(2R)-1-({(5R,8R)-5-[(3-fluorophenyl)methyl]-2,7-dioxo-1,6-diazacyclododecan-8-yl}amino)-1-oxo-3-phenylpropan-2-yl]carbamoyl}-L-valinate ; × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	Q8I0U7_PLAF7
Isoform	—
PDB entities	11
Chains and sequence ranges	Author chain H； PDBConstruct 1–282； UniProt 1–282 Author chain V； PDBConstruct 1–282； UniProt 1–282

Proteasome subunit beta

Plasmodium falciparum 3D7

UniProt Q8I6T3

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 28	Proteasome subunit alpha type × 2 （Q8IDG3） Proteasome subunit alpha type × 2 （Q8IDG2） Proteasome subunit alpha type × 2 （Q8IBI3） Proteasome endopeptidase complex × 2 （Q8IK90） Proteasome subunit alpha type-3, putative × 2 （O77396） Proteasome subunit beta × 2 （Q8IKC9） Proteasome subunit beta × 2 （Q8IJT1） Proteasome subunit beta × 2 （A0A5K1K7U1） Proteasome endopeptidase complex × 2 （Q8IAR3） Proteasome endopeptidase complex × 2 （C6KST3） Proteasome subunit beta type-6, putative × 2 （Q8I0U7） Proteasome subunit beta × 2 （Q8I261） Proteasome subunit beta × 2 （Q7K6A9） ;methyl N-{[(2R)-1-({(5R,8R)-5-[(3-fluorophenyl)methyl]-2,7-dioxo-1,6-diazacyclododecan-8-yl}amino)-1-oxo-3-phenylpropan-2-yl]carbamoyl}-L-valinate ; × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	Q8I6T3_PLAF7
Isoform	—
PDB entities	12
Chains and sequence ranges	Author chain I； PDBConstruct 1–270； UniProt 1–270 Author chain W； PDBConstruct 1–270； UniProt 1–270

Proteasome subunit beta

Plasmodium falciparum 3D7

UniProt Q8I261

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 28	Proteasome subunit alpha type × 2 （Q8IDG3） Proteasome subunit alpha type × 2 （Q8IDG2） Proteasome subunit alpha type × 2 （Q8IBI3） Proteasome endopeptidase complex × 2 （Q8IK90） Proteasome subunit alpha type-3, putative × 2 （O77396） Proteasome subunit beta × 2 （Q8IKC9） Proteasome subunit beta × 2 （Q8IJT1） Proteasome subunit beta × 2 （A0A5K1K7U1） Proteasome endopeptidase complex × 2 （Q8IAR3） Proteasome endopeptidase complex × 2 （C6KST3） Proteasome subunit beta type-6, putative × 2 （Q8I0U7） Proteasome subunit beta × 2 （Q8I6T3） Proteasome subunit beta × 2 （Q7K6A9） ;methyl N-{[(2R)-1-({(5R,8R)-5-[(3-fluorophenyl)methyl]-2,7-dioxo-1,6-diazacyclododecan-8-yl}amino)-1-oxo-3-phenylpropan-2-yl]carbamoyl}-L-valinate ; × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	Q8I261_PLAF7
Isoform	—
PDB entities	13
Chains and sequence ranges	Author chain J； PDBConstruct 1–218； UniProt 1–218 Author chain X； PDBConstruct 1–218； UniProt 1–218

Proteasome subunit beta

Plasmodium falciparum 3D7

UniProt Q7K6A9

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 28	Proteasome subunit alpha type × 2 （Q8IDG3） Proteasome subunit alpha type × 2 （Q8IDG2） Proteasome subunit alpha type × 2 （Q8IBI3） Proteasome endopeptidase complex × 2 （Q8IK90） Proteasome subunit alpha type-3, putative × 2 （O77396） Proteasome subunit beta × 2 （Q8IKC9） Proteasome subunit beta × 2 （Q8IJT1） Proteasome subunit beta × 2 （A0A5K1K7U1） Proteasome endopeptidase complex × 2 （Q8IAR3） Proteasome endopeptidase complex × 2 （C6KST3） Proteasome subunit beta type-6, putative × 2 （Q8I0U7） Proteasome subunit beta × 2 （Q8I6T3） Proteasome subunit beta × 2 （Q8I261） ;methyl N-{[(2R)-1-({(5R,8R)-5-[(3-fluorophenyl)methyl]-2,7-dioxo-1,6-diazacyclododecan-8-yl}amino)-1-oxo-3-phenylpropan-2-yl]carbamoyl}-L-valinate ; × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	Q7K6A9_PLAF7
Isoform	—
PDB entities	14
Chains and sequence ranges	Author chain N； PDBConstruct 1–265； UniProt 1–265 Author chain b； PDBConstruct 1–265； UniProt 1–265

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id	9yuy
Deposition date deposition_date	2025-10-23
Structure title title	Structure of the Plasmodium falciparum 20S proteasome in complex with a beta5-selective covalent syringolin analogue inhibitor.
Keywords keywords	Proteasome, 20S, Inhibitor, Plasmodium, Covalent, HYDROLASE; HYDROLASE
Experimental Method method	ELECTRON MICROSCOPY

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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

9yuy__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

9yuy__assembly_1__model_1 | I(q)

100 plotted points; both axes use logarithmic scales.

9yuy__assembly_1__model_1 | P(r) · Pending

P(r) will be calculated and displayed separately for the same assembly/model.

Rg（Guinier）	60.70 Å
Rg (electron density)	60.27 Å
Total Rg	60.55 Å
Atom count	100048
Residues	6284
Excluded volume	896730 Å³
Maximum q	0.500 Å⁻¹

Assembly	Model	Structure unit	Oligomeric description	Status	CRYSOL	Actions
1	1	`9yuy__assembly_1__model_1`	28-meric （28）	Success	4.1.3-1-20251215 (887e7ef)	View Download

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4. Crystallography and Experiment 4. Crystallography & Experiment

▶

5. Entities and Polymers Entities & Polymers (15)

Entity 1 Entity 1 polymer

Description description	Proteasome subunit alpha type
Molecular weight formula_weight	27977.7 kDa
EC 编号 ec_number	3.4.25.1
Source method src_method	man
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	C,Q
Atom count atom_count	100048

MARRYDSRTTTFSPEGRLYQVEYALEAINNASITIGLITKDGVILGADKVFISKLIDKANNYEKIYKIDKHIFCGVAGLNADANILINQSRLYAQRYLYNYNEVQPVSQLVVQICDIKQSYTQYGGLRPYGVSFLIGGYDTKDGYQLYHTDPSGNYSGWFATAIGTNNLTASSVLKQEWKNDMTLEEGLLLALKTLAKSTDTEIPKSEKIELAYLTNKDGEVYQKYLTEKEIEELIKLYTQKYIKE

Source Source

Source organism organism	Plasmodium falciparum 3D7
NCBI taxonomy ID ncbi_taxonomy_id	36329
Host organism host_organism	Spodoptera frugiperda

Entity 2 Entity 2 polymer

Description description	Proteasome subunit alpha type
Molecular weight formula_weight	27263.3 kDa
EC 编号 ec_number	3.4.25.1
Source method src_method	man
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	D,R

MSYDRAITVFSPDGHLLQVEHALEAVKKGGCAVAIKSSNFAVLAVEKKNIPKLQNPKTTEKLIKLDEHNCLAFAGLNADARVLVNKTRLECQRYYLNMDEPAPVDYIAKYVAKVQQKFTHRGGVRPFGIATLIAGFKNNKEICIYQTEPSGIYAAWKAQAIGKNAKIVQEFLEKNYQENMEQKDCIFLALKAIFEVVELSSKNVEVALLTEKDLTFIEEQEINSMVELIDQERTKNNEQNE

Source Source

Source organism organism	Plasmodium falciparum 3D7
NCBI taxonomy ID ncbi_taxonomy_id	36329
Host organism host_organism	Spodoptera frugiperda

Entity 3 Entity 3 polymer

Description description	Proteasome subunit alpha type
Molecular weight formula_weight	28417.4 kDa
EC 编号 ec_number	3.4.25.1
Source method src_method	man
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	E,S

MFSTRSEYDRGVNTFSPEGRLFQVEYALGAIKLGSTAVGICVNDGVILASERRISSTLIEKDSVEKLLSIDDHIGCAMSGLMADARTLIDYARVECNHYKFIYNENINIKSCVELISELALDFSNLSDSKRKKIMSRPFGVALLIGGVDKNGPCLWYTEPSGTNTRFSAASIGSAQEGAELLLQENYKKDMTFEQAEILALTVLRQVMEDKLSTSNVEICAIKKSDQTFYKYNTDDISRIIDVLPSPVYPTIDMTA

Source Source

Source organism organism	Plasmodium falciparum 3D7
NCBI taxonomy ID ncbi_taxonomy_id	36329
Host organism host_organism	Spodoptera frugiperda

Entity 4 Entity 4 polymer

Description description	Proteasome endopeptidase complex
Molecular weight formula_weight	28871.7 kDa
EC 编号 ec_number	3.4.25.1
Source method src_method	man
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	F,T

MYRNLYDTDNIIYSPEGRLYQVEYASEAIKQGTCAVAIKSKDYVVVSGLKKCISKLSFPQEKIFKIDDYIGISMSGITSDAKVLTKFMQNECLSHKFLYNENINIESLVRSVADKYQKNTQKSSKRAFGVGLMIAAYHNEPCIFETRPNGSYFEYDALSFGARSHASKTYLEKNLHLFEECSLEELILHCLKALKCSLSSESELTISNTALAVVGKNHPWQEISSLQLEEYLSKVKMDAEQEQVEENVQNEANE

Source Source

Source organism organism	Plasmodium falciparum 3D7
NCBI taxonomy ID ncbi_taxonomy_id	36329
Host organism host_organism	Spodoptera frugiperda

Entity 5 Entity 5 polymer

Description description	Proteasome subunit alpha type-3, putative
Molecular weight formula_weight	29324.3 kDa
EC 编号 ec_number	3.4.25.1
Source method src_method	man
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	G,U

MAGLSAGYDLSVSTFSPDGRLYQVEYIYKSINNNNTALCLECKDGIICCCINSNMDKNKMIKKNSYNRIYHVNNNIIITYSGFDGDARNIIDRARSEANTYYYNFHTNIPLHILVNRISLYIHAYTLYWHMRPFAASIIISSFNEKDKGDIYCIEPNGACYKYSGIVIGKNKEMFKTEIEKKDYKDINVRDAIEDIYKFILTSDDHMNKNNLQNLVNFSWICKESSYEFQNIHEEILTPALNKAVEYIEKLN

Source Source

Source organism organism	Plasmodium falciparum 3D7
NCBI taxonomy ID ncbi_taxonomy_id	36329
Host organism host_organism	Spodoptera frugiperda

Entity 6 Entity 6 polymer

Description description	Proteasome subunit beta
Molecular weight formula_weight	22889.1 kDa
EC 编号 ec_number	3.4.25.1
Source method src_method	man
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	K,Y

MDTLIGLRGNNFVVLAADTYSINSIIKLKNDDNTKFYDIHGNKCLLLGGSIGDRLQFGEFIRKNVHLYQYQNNTDMFVKSFAFFTRKNLAYYLRRNPFEVNCLIAGYDKKDGYQLYWCDYLSNMDSVNKGAHGYGAYLVSAILDKYYHENLTVDEALDIFKLCFEELKKRFLLTQINYELRIMYDNKVETQYVTV

Source Source

Source organism organism	Plasmodium falciparum 3D7
NCBI taxonomy ID ncbi_taxonomy_id	36329
Host organism host_organism	Spodoptera frugiperda

Entity 7 Entity 7 polymer

Description description	Proteasome subunit beta
Molecular weight formula_weight	30630.4 kDa
Source method src_method	man
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	L,Z

MVIASDESFMNEIDNLINDVEDERIDNDELEFCVAPVNVPRNFIKYAQTQNKKLFDFHKGTTTLAFKFKDGIIVAVDSRASMGSFISSQNVEKIIEINKNILGTMAGGAADCLYWEKYLGKIIKIYELRNNEKISVRAASTILSNILYQYKGYGLCCGIILSGYDHTGFNMFYVDDSGKKVEGNLFSCGSGSTYAYSILDSAYDYNLNLDQAVELARNAIYHATFRDGGSGGKVRVFHIHKNGYDKIIEGEDVFDLHYHYTNPEQKDQYVM

Source Source

Source organism organism	Plasmodium falciparum 3D7
NCBI taxonomy ID ncbi_taxonomy_id	36329
Host organism host_organism	Spodoptera frugiperda

Entity 8 Entity 8 polymer

Description description	Proteasome subunit beta
Molecular weight formula_weight	27301.2 kDa
EC 编号 ec_number	3.4.25.1
Source method src_method	man
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	M,a

MDLILYNDNLTEKKTEKENVIEHGRGFKRWYPYIDNGGTVIGLTGKDYVILAADTRLSLSYSIYTRFCPKISKLTDKCIIGSSGMQSDIKTLHSLLQKKIQLFVLEHSHYPDIHVIARLLCVILYSRRFFPYYAFNILAGVDENNKGVLYNYDSVGSYCEATHSCVGSGSQLILPILDNRVEQKNQLIKNTNFNLGDDINFVKDAITSATERDIYTGDKTLIYVIDKMGINVNTLDLKQD

Source Source

Source organism organism	Plasmodium falciparum 3D7
NCBI taxonomy ID ncbi_taxonomy_id	36329
Host organism host_organism	Spodoptera frugiperda

Entity 9 Entity 9 polymer

Description description	Proteasome endopeptidase complex
Molecular weight formula_weight	29531.7 kDa
EC 编号 ec_number	3.4.25.1
Source method src_method	man
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	A,O

MVRPSQSMYDRHLTIFSPDGNLYQIEYAIKAVKNTNITSVGVKGENCAVIISQKKMATQYISQDKLLDYNNITNIYNITDEIGCSMVGMPGDCLSMVYKARSEASEFLYSNGYNVNAETLCRNICDKIQVYTQHAYMRLHACSGMIIGIDENNKPELFKFDPSGFCAGYRACVIGNKEQESISVLERLLEKRKKKIQQETIDEDIRNTTILAIEALQTILAFDLKASEIEVAIVSTKNRNFTQISEKEIDNYLTYIAERD

Source Source

Source organism organism	Plasmodium falciparum 3D7
NCBI taxonomy ID ncbi_taxonomy_id	36329
Host organism host_organism	Spodoptera frugiperda

Entity 10 Entity 10 polymer

Description description	Proteasome endopeptidase complex
Molecular weight formula_weight	26556.4 kDa
EC 编号 ec_number	3.4.25.1
Source method src_method	man
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	B,P

MADGEYSFSLTTFSPTGKLVQIEYALNRVSSSSPALGIRAKNGVIIATEKKSPNELIEENSIFKIQQISEHIGIVYAGMPGDFRVLLKRARKEAIRYSLQYGSEILVKELVKIIASIVQEFTQTGGVRPFGLSLLICGVDVYGYHLYQIDPSGCYFNWMATCVGKDYQNNMSFLEKRYNKDIEIEDAIHTAILTLKESYEGVLNEKNIEIGVAYDNKPFKILTQNEIKDYLIEIE

Source Source

Source organism organism	Plasmodium falciparum 3D7
NCBI taxonomy ID ncbi_taxonomy_id	36329
Host organism host_organism	Spodoptera frugiperda

Entity 11 Entity 11 polymer

Description description	Proteasome subunit beta type-6, putative
Molecular weight formula_weight	32641.7 kDa
EC 编号 ec_number	3.4.25.1
Source method src_method	man
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	H,V

MDVVNESQIKCHEEKSWDDEYDIKTPISDGTTIIGIIYDNGVMLACDSRTSSGTFISNKCSRKINRINENLYVCRSGASAHSQKIIEIIKHYCVSMKNENRKKGRFHEGETIYDETTYDEEIDIDSINYLDYNNNNDNNLVTKNKYFYEDKFNDYNPLVENVAHITKKIIYTNNNFLSCALIFGGYDKIKKQQLYAVNLNGSIIEKHDFAVSGSGSIYIQSYLQDKYKKFMTKKECFNLILNCVKYAMHNDNSSGGLIRIVNITKSFVEEFTVVNTQMNFQY

Source Source

Source organism organism	Plasmodium falciparum 3D7
NCBI taxonomy ID ncbi_taxonomy_id	36329
Host organism host_organism	Spodoptera frugiperda

Entity 12 Entity 12 polymer

Description description	Proteasome subunit beta
Molecular weight formula_weight	29999.6 kDa
Source method src_method	man
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	I,W

MKLEYINILKEENGGYNFDNLKRNEILKEKGVKFPQFRKTGTTICGLVCQNAVILGADTRATEGPIVADKNCSKLHYISKNIWCAGAGVAGDLEHTTLWLQHNVELHRLNTNTQPRVSMCVSRLTQELFKYQGYKVCAIVLGGVDVNGPQLYGIHPHGSSCLLPFTALGSGSLNAMAVLEAKYRDNMTIEEGKNLVCEAICAGIFNDLGSGGNVDICVITKDSYQHIRPYKEPNMRLYHLPHPTIYPKGTTPILSEKIEYIKKFISVEDA

Source Source

Source organism organism	Plasmodium falciparum 3D7
NCBI taxonomy ID ncbi_taxonomy_id	36329
Host organism host_organism	Spodoptera frugiperda

Entity 13 Entity 13 polymer

Description description	Proteasome subunit beta
Molecular weight formula_weight	24533.1 kDa
EC 编号 ec_number	3.4.25.1
Source method src_method	man
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	J,X

MGSIYNYNGGCVLGMSGSNCVAIACDLRLGANTFTTVSTKFSKIFKMNNNVYVGLSGLATDIQTLYEILRYRVNLYEVRQDAEMDVECFANMLSSILYSNRFSPYFVNPIVVGFKLKHYVDEEGEKKVNYEPYLTAYDLIGAKCETRDFVVNGVTSEQLFGMCESLYVKDQDENGLFETISQCLLSALDRDCISGWGAEVLVLTPEKIIKKKLKARMD

Source Source

Source organism organism	Plasmodium falciparum 3D7
NCBI taxonomy ID ncbi_taxonomy_id	36329
Host organism host_organism	Spodoptera frugiperda

Entity 14 Entity 14 polymer

Description description	Proteasome subunit beta
Molecular weight formula_weight	30909.9 kDa
EC 编号 ec_number	3.4.25.1
Source method src_method	man
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	N,b

MTLGPVVTGTSVIAIKYKHGIMIAADRKASYGSYAKFQNVERIFKINNKTVMGFSGELADAQYLHELLTRKNINNLSEKKRKEDMYTPQHYHSYVSRVFYVRKNRIDPLFNNIIIAGINSQKYDNNDDNVLLYTNKNNDDEQNEYKNNEEYKEIHKDDLYIGFVDMHGTNFCDDYITTGYARYFALTLLRDHYKDNMTEEEARILINECLRILYFRDATSSNFIQIVKVTSKGVEYEEPYILPCVLNSADYVYPSTLLPPAGCMW

Source Source

Source organism organism	Plasmodium falciparum 3D7
NCBI taxonomy ID ncbi_taxonomy_id	36329
Host organism host_organism	Spodoptera frugiperda

Entity 15 Entity 15 non-polymer

Description description	;methyl N-{[(2R)-1-({(5R,8R)-5-[(3-fluorophenyl)methyl]-2,7-dioxo-1,6-diazacyclododecan-8-yl}amino)-1-oxo-3-phenylpropan-2-yl]carbamoyl}-L-valinate ;
Molecular weight formula_weight	625.7 kDa
Source method src_method	syn
Copy count entity_count	2

▶

Unit-cell length a length_a	1.000 Å
Unit-cell length b length_b	1.000 Å
Unit-cell length c length_c	1.000 Å
Unit-cell angle α angle_alpha	90.00 °
Unit-cell angle β angle_beta	90.00 °
Unit-cell angle γ angle_gamma	90.00 °
Molecules per unit cell Z z_pdb	—

Space group space_group	P 1
Space-group number int_tables_number	1
Crystal system crystal_system	—

Resolution resolution	2.700 Å
Low-resolution limit resolution_low	— Å
R factor r_factor	—
R_work r_work	—
R_free r_free	—

Resolution resolution	2.70 Å
Resolution测定Method resolution_method	—
颗粒数 num_particles	36364

Structure of the Plasmodium falciparum 20S proteasome in complex with a beta5-selective covalent syringolin analogue inhibitor.

1. Protein Identity and Related Structures Protein Identity & Related Structures

Proteasome subunit alpha type

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

Proteasome subunit alpha type

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

Proteasome subunit alpha type

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

Proteasome endopeptidase complex

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

Proteasome subunit alpha type-3, putative

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

Proteasome subunit beta

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

Proteasome subunit beta

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

Proteasome subunit beta

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

Proteasome endopeptidase complex

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

Proteasome endopeptidase complex

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer