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9y0l

Incorrectly assembled half-Pf20S

Method: ELECTRON MICROSCOPY Dmax: 136.9 Å Quality: GOOD
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Proteasome subunit alpha type-6

Plasmodium falciparum Dd2

UniProt Q8IAR3

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 15 PDB declaration: pentadecameric（15） Consistent with protein copy count Chain A； UniProt 1–260 Not recorded Proteasome subunit alpha type-2 × 1 （C6KST3） Proteasome subunit alpha type-3 × 1 （Q8IDG3） Proteasome subunit alpha type-4 × 1 （Q8IDG2） Proteasome subunit alpha type-5 × 1 （A0A0L7LVZ5） Proteasome subunit alpha type-1 × 1 （Q8IK90） Proteasome subunit alpha type-3 × 1 （O77396） Proteasome endopeptidase complex × 1 （A0A0L7M1M6） Proteasome subunit beta × 1 （W7K1J4） Proteasome subunit beta-3 × 1 （Q8I261） Proteasome subunit beta-4 × 1 （Q8IKC9） Proteasome subunit beta × 1 （W7K6A8） Proteasome subunit beta × 1 （A0A2I0BU46） Proteasome subunit beta × 1 （A0A0L7LW03） Proteasome maturation factor UMP1 × 1 （W7K992） ELECTRON MICROSCOPY cryo-EM buffer：pH 7.5 cryo-EM vitrification conditions：Cryogen ETHANE Resolution 3.00 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 9Y0L Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
5FMG Structure and function based design of Plasmodium-selective proteasome inhibitors Deposited 2015-11-04 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain A 1–260（260 aa）
Chain O 1–260（260 aa）
Not recorded 7F1 (2S)-N-[(E,2S)-1-(1H-indol-3-yl)-4-methylsulfonyl-but-3-en-2-yl]-2-[[(2S)-3-(1H-indol-3-yl)-2-(2-morpholin-4-ylethanoylamino)propanoyl]amino]-4-methyl-pentanamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer 50MM TRIS HCL, 5MM MGCL2, 1MM DITHIOTREITOL；pH 7.5；50MM TRIS HCL, 5MM MGCL2, 1MM DITHIOTREITOL
cryo-EM vitrification conditions Cryogen ETHANE；VITRIFICATION 1 -- CRYOGEN- ETHANE, HUMIDITY- 95, INSTRUMENT- FEI VITROBOT MARK III, METHOD- BLOT 2.5 SECONDS BEFORE PLUNGING,
Resolution 3.60 Å
6MUV The structure of the Plasmodium falciparum 20S proteasome in complex with two PA28 activators Deposited 2018-10-23 Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 42 PDB declaration: 42-meric
Chain A 1–260（260 aa）
Chain O 1–260（260 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE；wait time 0sec blot time 2sec blot force -1
Resolution 3.80 Å
6MUW The structure of the Plasmodium falciparum 20S proteasome. Deposited 2018-10-23 Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain A 1–260（260 aa）
Chain O 1–260（260 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE；wait time 0sec blot time 2sec blot force -1
Resolution 3.60 Å
6MUX The structure of the Plasmodium falciparum 20S proteasome in complex with one PA28 activator Deposited 2018-10-23 Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 35 PDB declaration: 35-meric
Chain A 1–260（260 aa）
Chain O 1–260（260 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE；wait time 0sec blot time 2sec blot force -1
Resolution 3.90 Å
7LXT Structure of Plasmodium falciparum 20S proteasome with bound bortezomib Deposited 2021-03-05 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain A 1–260（260 aa）
Chain O 1–260（260 aa）
Not recorded BO2 N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE × 6 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.40 Å
7LXU Structure of Plasmodium falciparum 20S proteasome with bound MPI-5 Deposited 2021-03-05 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain A 1–260（260 aa）
Chain O 1–260（260 aa）
Not recorded YHD N-[(1R)-2-([1,1'-biphenyl]-4-yl)-1-boronoethyl]-1-methyl-L-prolinamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
8G6F Structure of the Plasmodium falciparum 20S proteasome beta-6 A117D mutant complexed with inhibitor WLW-vs Deposited 2023-02-15 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain A 1–260（260 aa）
Chain O 1–260（260 aa）
Not recorded 7F1 (2S)-N-[(E,2S)-1-(1H-indol-3-yl)-4-methylsulfonyl-but-3-en-2-yl]-2-[[(2S)-3-(1H-indol-3-yl)-2-(2-morpholin-4-ylethanoylamino)propanoyl]amino]-4-methyl-pentanamide × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.58 Å
8W2F Plasmodium falciparum 20S proteasome bound to an inhibitor Deposited 2024-02-20 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain A 1–260（260 aa）
Chain O 1–260（260 aa）
Not recorded A1AE6 (3S)-1-[(2-fluoroethoxy)acetyl]-N-{[(4P)-4-(6-methylpyridin-3-yl)-1,3-thiazol-2-yl]methyl}piperidine-3-carboxamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
9O3E Plasmodium falciparum 20S proteasome bound to inhibitor 159 Deposited 2025-04-07 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain A 1–260（260 aa）
Chain O 1–260（260 aa）
Not recorded A1B74 (3S)-N~3~-{(1S)-1-[4-(4-cyanophenyl)-1,3-thiazol-2-yl]ethyl}-N~1~-ethoxypiperidine-1,3-dicarboxamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.79 Å
9O3F Plasmodium falciparum 20S proteasome bound to inhibitor 296 Deposited 2025-04-07 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain A 1–260（260 aa）
Chain O 1–260（260 aa）
Not recorded A1B73 (3S)-1-({[(3S)-piperidin-3-yl]oxy}acetyl)-N-({4-[4-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl}methyl)piperidine-3-carboxamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.28 Å
9Y0K Structure of Plasmodium falciparum 20S proteasome with bound J80 Deposited 2025-08-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain A 1–260（260 aa）
Chain O 1–260（260 aa）
Not recorded A1CRO N,N-diethyl-N~2~-hexanoyl-D-asparaginyl-N-{(1S)-2-(2,4-difluorophenyl)-1-[(2S,3S,5S,6S)-5-formyl-2-hydroxy-3-(hydroxymethyl)-3,6-dimethylmorpholin-2-yl]ethyl}-4-fluoro-L-phenylalaninamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.00 Å
9Y1O The structure of the Plasmodium falciparum 20S proteasome Deposited 2025-08-29 Different construct Different mutation/modification Different oligomeric state Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain A 1–260（260 aa）
Chain O 1–260（260 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
9YUY Structure of the Plasmodium falciparum 20S proteasome in complex with a beta5-selective covalent syringolin analogue inhibitor. Deposited 2025-10-23 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain A 1–260（260 aa）
Chain O 1–260（260 aa）
Not recorded A1CY6 methyl N-{[(2R)-1-({(5R,8R)-5-[(3-fluorophenyl)methyl]-2,7-dioxo-1,6-diazacyclododecan-8-yl}amino)-1-oxo-3-phenylpropan-2-yl]carbamoyl}-L-valinate × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.70 Å

13 other PDB entries and 13 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name Q8IAR3_PLAF7
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–260； UniProt 1–260

Proteasome subunit alpha type-2

Plasmodium falciparum Dd2

UniProt C6KST3

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 15 PDB declaration: pentadecameric（15） Consistent with protein copy count Chain B； UniProt 1–235 Not recorded Proteasome subunit alpha type-6 × 1 （Q8IAR3） Proteasome subunit alpha type-3 × 1 （Q8IDG3） Proteasome subunit alpha type-4 × 1 （Q8IDG2） Proteasome subunit alpha type-5 × 1 （A0A0L7LVZ5） Proteasome subunit alpha type-1 × 1 （Q8IK90） Proteasome subunit alpha type-3 × 1 （O77396） Proteasome endopeptidase complex × 1 （A0A0L7M1M6） Proteasome subunit beta × 1 （W7K1J4） Proteasome subunit beta-3 × 1 （Q8I261） Proteasome subunit beta-4 × 1 （Q8IKC9） Proteasome subunit beta × 1 （W7K6A8） Proteasome subunit beta × 1 （A0A2I0BU46） Proteasome subunit beta × 1 （A0A0L7LW03） Proteasome maturation factor UMP1 × 1 （W7K992） ELECTRON MICROSCOPY cryo-EM buffer：pH 7.5 cryo-EM vitrification conditions：Cryogen ETHANE Resolution 3.00 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 9Y0L Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
5FMG Structure and function based design of Plasmodium-selective proteasome inhibitors Deposited 2015-11-04 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain B 1–235（235 aa）
Chain P 1–235（235 aa）
Not recorded 7F1 (2S)-N-[(E,2S)-1-(1H-indol-3-yl)-4-methylsulfonyl-but-3-en-2-yl]-2-[[(2S)-3-(1H-indol-3-yl)-2-(2-morpholin-4-ylethanoylamino)propanoyl]amino]-4-methyl-pentanamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer 50MM TRIS HCL, 5MM MGCL2, 1MM DITHIOTREITOL；pH 7.5；50MM TRIS HCL, 5MM MGCL2, 1MM DITHIOTREITOL
cryo-EM vitrification conditions Cryogen ETHANE；VITRIFICATION 1 -- CRYOGEN- ETHANE, HUMIDITY- 95, INSTRUMENT- FEI VITROBOT MARK III, METHOD- BLOT 2.5 SECONDS BEFORE PLUNGING,
Resolution 3.60 Å
6MUV The structure of the Plasmodium falciparum 20S proteasome in complex with two PA28 activators Deposited 2018-10-23 Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 42 PDB declaration: 42-meric
Chain B 1–235（235 aa）
Chain P 1–235（235 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE；wait time 0sec blot time 2sec blot force -1
Resolution 3.80 Å
6MUW The structure of the Plasmodium falciparum 20S proteasome. Deposited 2018-10-23 Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain B 1–235（235 aa）
Chain P 1–235（235 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE；wait time 0sec blot time 2sec blot force -1
Resolution 3.60 Å
6MUX The structure of the Plasmodium falciparum 20S proteasome in complex with one PA28 activator Deposited 2018-10-23 Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 35 PDB declaration: 35-meric
Chain B 1–235（235 aa）
Chain P 1–235（235 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE；wait time 0sec blot time 2sec blot force -1
Resolution 3.90 Å
7LXT Structure of Plasmodium falciparum 20S proteasome with bound bortezomib Deposited 2021-03-05 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain B 1–235（235 aa）
Chain P 1–235（235 aa）
Not recorded BO2 N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE × 6 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.40 Å
7LXU Structure of Plasmodium falciparum 20S proteasome with bound MPI-5 Deposited 2021-03-05 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain B 1–235（235 aa）
Chain P 1–235（235 aa）
Not recorded YHD N-[(1R)-2-([1,1'-biphenyl]-4-yl)-1-boronoethyl]-1-methyl-L-prolinamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
8G6F Structure of the Plasmodium falciparum 20S proteasome beta-6 A117D mutant complexed with inhibitor WLW-vs Deposited 2023-02-15 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain B 1–235（235 aa）
Chain P 1–235（235 aa）
Not recorded 7F1 (2S)-N-[(E,2S)-1-(1H-indol-3-yl)-4-methylsulfonyl-but-3-en-2-yl]-2-[[(2S)-3-(1H-indol-3-yl)-2-(2-morpholin-4-ylethanoylamino)propanoyl]amino]-4-methyl-pentanamide × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.58 Å
8W2F Plasmodium falciparum 20S proteasome bound to an inhibitor Deposited 2024-02-20 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain B 1–235（235 aa）
Chain P 1–235（235 aa）
Not recorded A1AE6 (3S)-1-[(2-fluoroethoxy)acetyl]-N-{[(4P)-4-(6-methylpyridin-3-yl)-1,3-thiazol-2-yl]methyl}piperidine-3-carboxamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
9O3E Plasmodium falciparum 20S proteasome bound to inhibitor 159 Deposited 2025-04-07 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain B 1–235（235 aa）
Chain P 1–235（235 aa）
Not recorded A1B74 (3S)-N~3~-{(1S)-1-[4-(4-cyanophenyl)-1,3-thiazol-2-yl]ethyl}-N~1~-ethoxypiperidine-1,3-dicarboxamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.79 Å
9O3F Plasmodium falciparum 20S proteasome bound to inhibitor 296 Deposited 2025-04-07 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain B 1–235（235 aa）
Chain P 1–235（235 aa）
Not recorded A1B73 (3S)-1-({[(3S)-piperidin-3-yl]oxy}acetyl)-N-({4-[4-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl}methyl)piperidine-3-carboxamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.28 Å
9Y0K Structure of Plasmodium falciparum 20S proteasome with bound J80 Deposited 2025-08-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain B 1–235（235 aa）
Chain P 1–235（235 aa）
Not recorded A1CRO N,N-diethyl-N~2~-hexanoyl-D-asparaginyl-N-{(1S)-2-(2,4-difluorophenyl)-1-[(2S,3S,5S,6S)-5-formyl-2-hydroxy-3-(hydroxymethyl)-3,6-dimethylmorpholin-2-yl]ethyl}-4-fluoro-L-phenylalaninamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.00 Å
9Y1O The structure of the Plasmodium falciparum 20S proteasome Deposited 2025-08-29 Different construct Different mutation/modification Different oligomeric state Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain B 1–235（235 aa）
Chain P 1–235（235 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
9YUY Structure of the Plasmodium falciparum 20S proteasome in complex with a beta5-selective covalent syringolin analogue inhibitor. Deposited 2025-10-23 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain B 1–235（235 aa）
Chain P 1–235（235 aa）
Not recorded A1CY6 methyl N-{[(2R)-1-({(5R,8R)-5-[(3-fluorophenyl)methyl]-2,7-dioxo-1,6-diazacyclododecan-8-yl}amino)-1-oxo-3-phenylpropan-2-yl]carbamoyl}-L-valinate × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.70 Å

13 other PDB entries and 13 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name C6KST3_PLAF7
Isoform —
PDB entities 2
Chains and sequence ranges Author chain B； PDBConstruct 1–235； UniProt 1–235

Proteasome subunit alpha type-3

Plasmodium falciparum Dd2

UniProt Q8IDG3

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 15 PDB declaration: pentadecameric（15） Consistent with protein copy count Chain C； UniProt 1–246 Not recorded Proteasome subunit alpha type-6 × 1 （Q8IAR3） Proteasome subunit alpha type-2 × 1 （C6KST3） Proteasome subunit alpha type-4 × 1 （Q8IDG2） Proteasome subunit alpha type-5 × 1 （A0A0L7LVZ5） Proteasome subunit alpha type-1 × 1 （Q8IK90） Proteasome subunit alpha type-3 × 1 （O77396） Proteasome endopeptidase complex × 1 （A0A0L7M1M6） Proteasome subunit beta × 1 （W7K1J4） Proteasome subunit beta-3 × 1 （Q8I261） Proteasome subunit beta-4 × 1 （Q8IKC9） Proteasome subunit beta × 1 （W7K6A8） Proteasome subunit beta × 1 （A0A2I0BU46） Proteasome subunit beta × 1 （A0A0L7LW03） Proteasome maturation factor UMP1 × 1 （W7K992） ELECTRON MICROSCOPY cryo-EM buffer：pH 7.5 cryo-EM vitrification conditions：Cryogen ETHANE Resolution 3.00 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 9Y0L Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
5FMG Structure and function based design of Plasmodium-selective proteasome inhibitors Deposited 2015-11-04 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain C 1–246（246 aa）
Chain Q 1–246（246 aa）
Not recorded 7F1 (2S)-N-[(E,2S)-1-(1H-indol-3-yl)-4-methylsulfonyl-but-3-en-2-yl]-2-[[(2S)-3-(1H-indol-3-yl)-2-(2-morpholin-4-ylethanoylamino)propanoyl]amino]-4-methyl-pentanamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer 50MM TRIS HCL, 5MM MGCL2, 1MM DITHIOTREITOL；pH 7.5；50MM TRIS HCL, 5MM MGCL2, 1MM DITHIOTREITOL
cryo-EM vitrification conditions Cryogen ETHANE；VITRIFICATION 1 -- CRYOGEN- ETHANE, HUMIDITY- 95, INSTRUMENT- FEI VITROBOT MARK III, METHOD- BLOT 2.5 SECONDS BEFORE PLUNGING,
Resolution 3.60 Å
6MUV The structure of the Plasmodium falciparum 20S proteasome in complex with two PA28 activators Deposited 2018-10-23 Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 42 PDB declaration: 42-meric
Chain C 1–246（246 aa）
Chain Q 1–246（246 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE；wait time 0sec blot time 2sec blot force -1
Resolution 3.80 Å
6MUW The structure of the Plasmodium falciparum 20S proteasome. Deposited 2018-10-23 Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain C 1–246（246 aa）
Chain Q 1–246（246 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE；wait time 0sec blot time 2sec blot force -1
Resolution 3.60 Å
6MUX The structure of the Plasmodium falciparum 20S proteasome in complex with one PA28 activator Deposited 2018-10-23 Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 35 PDB declaration: 35-meric
Chain C 1–246（246 aa）
Chain Q 1–246（246 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE；wait time 0sec blot time 2sec blot force -1
Resolution 3.90 Å
7LXT Structure of Plasmodium falciparum 20S proteasome with bound bortezomib Deposited 2021-03-05 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain C 1–246（246 aa）
Chain Q 1–246（246 aa）
Not recorded BO2 N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE × 6 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.40 Å
7LXU Structure of Plasmodium falciparum 20S proteasome with bound MPI-5 Deposited 2021-03-05 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain C 1–246（246 aa）
Chain Q 1–246（246 aa）
Not recorded YHD N-[(1R)-2-([1,1'-biphenyl]-4-yl)-1-boronoethyl]-1-methyl-L-prolinamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
8G6F Structure of the Plasmodium falciparum 20S proteasome beta-6 A117D mutant complexed with inhibitor WLW-vs Deposited 2023-02-15 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain C 1–246（246 aa）
Chain Q 1–246（246 aa）
Not recorded 7F1 (2S)-N-[(E,2S)-1-(1H-indol-3-yl)-4-methylsulfonyl-but-3-en-2-yl]-2-[[(2S)-3-(1H-indol-3-yl)-2-(2-morpholin-4-ylethanoylamino)propanoyl]amino]-4-methyl-pentanamide × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.58 Å
8W2F Plasmodium falciparum 20S proteasome bound to an inhibitor Deposited 2024-02-20 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain C 1–242（242 aa）
Chain Q 1–242（242 aa）
Not recorded A1AE6 (3S)-1-[(2-fluoroethoxy)acetyl]-N-{[(4P)-4-(6-methylpyridin-3-yl)-1,3-thiazol-2-yl]methyl}piperidine-3-carboxamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
9O3E Plasmodium falciparum 20S proteasome bound to inhibitor 159 Deposited 2025-04-07 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain C 1–246（246 aa）
Chain Q 1–246（246 aa）
Not recorded A1B74 (3S)-N~3~-{(1S)-1-[4-(4-cyanophenyl)-1,3-thiazol-2-yl]ethyl}-N~1~-ethoxypiperidine-1,3-dicarboxamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.79 Å
9O3F Plasmodium falciparum 20S proteasome bound to inhibitor 296 Deposited 2025-04-07 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain C 1–242（242 aa）
Chain Q 1–242（242 aa）
Not recorded A1B73 (3S)-1-({[(3S)-piperidin-3-yl]oxy}acetyl)-N-({4-[4-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl}methyl)piperidine-3-carboxamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.28 Å
9Y0K Structure of Plasmodium falciparum 20S proteasome with bound J80 Deposited 2025-08-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain C 1–246（246 aa）
Chain Q 1–246（246 aa）
Not recorded A1CRO N,N-diethyl-N~2~-hexanoyl-D-asparaginyl-N-{(1S)-2-(2,4-difluorophenyl)-1-[(2S,3S,5S,6S)-5-formyl-2-hydroxy-3-(hydroxymethyl)-3,6-dimethylmorpholin-2-yl]ethyl}-4-fluoro-L-phenylalaninamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.00 Å
9Y1O The structure of the Plasmodium falciparum 20S proteasome Deposited 2025-08-29 Different construct Different mutation/modification Different oligomeric state Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain C 1–246（246 aa）
Chain Q 1–246（246 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
9YUY Structure of the Plasmodium falciparum 20S proteasome in complex with a beta5-selective covalent syringolin analogue inhibitor. Deposited 2025-10-23 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain C 1–246（246 aa）
Chain Q 1–246（246 aa）
Not recorded A1CY6 methyl N-{[(2R)-1-({(5R,8R)-5-[(3-fluorophenyl)methyl]-2,7-dioxo-1,6-diazacyclododecan-8-yl}amino)-1-oxo-3-phenylpropan-2-yl]carbamoyl}-L-valinate × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.70 Å

13 other PDB entries and 13 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name Q8IDG3_PLAF7
Isoform —
PDB entities 3
Chains and sequence ranges Author chain C； PDBConstruct 1–246； UniProt 1–246

Proteasome subunit alpha type-4

Plasmodium falciparum Dd2

UniProt Q8IDG2

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 15 PDB declaration: pentadecameric（15） Consistent with protein copy count Chain D； UniProt 1–241 Not recorded Proteasome subunit alpha type-6 × 1 （Q8IAR3） Proteasome subunit alpha type-2 × 1 （C6KST3） Proteasome subunit alpha type-3 × 1 （Q8IDG3） Proteasome subunit alpha type-5 × 1 （A0A0L7LVZ5） Proteasome subunit alpha type-1 × 1 （Q8IK90） Proteasome subunit alpha type-3 × 1 （O77396） Proteasome endopeptidase complex × 1 （A0A0L7M1M6） Proteasome subunit beta × 1 （W7K1J4） Proteasome subunit beta-3 × 1 （Q8I261） Proteasome subunit beta-4 × 1 （Q8IKC9） Proteasome subunit beta × 1 （W7K6A8） Proteasome subunit beta × 1 （A0A2I0BU46） Proteasome subunit beta × 1 （A0A0L7LW03） Proteasome maturation factor UMP1 × 1 （W7K992） ELECTRON MICROSCOPY cryo-EM buffer：pH 7.5 cryo-EM vitrification conditions：Cryogen ETHANE Resolution 3.00 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 9Y0L Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
5FMG Structure and function based design of Plasmodium-selective proteasome inhibitors Deposited 2015-11-04 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain D 1–241（241 aa）
Chain R 1–241（241 aa）
Not recorded 7F1 (2S)-N-[(E,2S)-1-(1H-indol-3-yl)-4-methylsulfonyl-but-3-en-2-yl]-2-[[(2S)-3-(1H-indol-3-yl)-2-(2-morpholin-4-ylethanoylamino)propanoyl]amino]-4-methyl-pentanamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer 50MM TRIS HCL, 5MM MGCL2, 1MM DITHIOTREITOL；pH 7.5；50MM TRIS HCL, 5MM MGCL2, 1MM DITHIOTREITOL
cryo-EM vitrification conditions Cryogen ETHANE；VITRIFICATION 1 -- CRYOGEN- ETHANE, HUMIDITY- 95, INSTRUMENT- FEI VITROBOT MARK III, METHOD- BLOT 2.5 SECONDS BEFORE PLUNGING,
Resolution 3.60 Å
6MUV The structure of the Plasmodium falciparum 20S proteasome in complex with two PA28 activators Deposited 2018-10-23 Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 42 PDB declaration: 42-meric
Chain D 1–241（241 aa）
Chain R 1–241（241 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE；wait time 0sec blot time 2sec blot force -1
Resolution 3.80 Å
6MUW The structure of the Plasmodium falciparum 20S proteasome. Deposited 2018-10-23 Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain D 1–241（241 aa）
Chain R 1–241（241 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE；wait time 0sec blot time 2sec blot force -1
Resolution 3.60 Å
6MUX The structure of the Plasmodium falciparum 20S proteasome in complex with one PA28 activator Deposited 2018-10-23 Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 35 PDB declaration: 35-meric
Chain D 1–241（241 aa）
Chain R 1–241（241 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE；wait time 0sec blot time 2sec blot force -1
Resolution 3.90 Å
7LXT Structure of Plasmodium falciparum 20S proteasome with bound bortezomib Deposited 2021-03-05 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain D 1–241（241 aa）
Chain R 1–241（241 aa）
Not recorded BO2 N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE × 6 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.40 Å
7LXU Structure of Plasmodium falciparum 20S proteasome with bound MPI-5 Deposited 2021-03-05 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain D 1–241（241 aa）
Chain R 1–241（241 aa）
Not recorded YHD N-[(1R)-2-([1,1'-biphenyl]-4-yl)-1-boronoethyl]-1-methyl-L-prolinamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
8G6F Structure of the Plasmodium falciparum 20S proteasome beta-6 A117D mutant complexed with inhibitor WLW-vs Deposited 2023-02-15 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain D 1–241（241 aa）
Chain R 1–241（241 aa）
Not recorded 7F1 (2S)-N-[(E,2S)-1-(1H-indol-3-yl)-4-methylsulfonyl-but-3-en-2-yl]-2-[[(2S)-3-(1H-indol-3-yl)-2-(2-morpholin-4-ylethanoylamino)propanoyl]amino]-4-methyl-pentanamide × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.58 Å
8W2F Plasmodium falciparum 20S proteasome bound to an inhibitor Deposited 2024-02-20 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain D 1–241（241 aa）
Chain R 1–241（241 aa）
Not recorded A1AE6 (3S)-1-[(2-fluoroethoxy)acetyl]-N-{[(4P)-4-(6-methylpyridin-3-yl)-1,3-thiazol-2-yl]methyl}piperidine-3-carboxamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
9O3E Plasmodium falciparum 20S proteasome bound to inhibitor 159 Deposited 2025-04-07 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain D 1–241（241 aa）
Chain R 1–241（241 aa）
Not recorded A1B74 (3S)-N~3~-{(1S)-1-[4-(4-cyanophenyl)-1,3-thiazol-2-yl]ethyl}-N~1~-ethoxypiperidine-1,3-dicarboxamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.79 Å
9O3F Plasmodium falciparum 20S proteasome bound to inhibitor 296 Deposited 2025-04-07 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain D 1–241（241 aa）
Chain R 1–241（241 aa）
Not recorded A1B73 (3S)-1-({[(3S)-piperidin-3-yl]oxy}acetyl)-N-({4-[4-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl}methyl)piperidine-3-carboxamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.28 Å
9Y0K Structure of Plasmodium falciparum 20S proteasome with bound J80 Deposited 2025-08-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain D 1–241（241 aa）
Chain R 1–241（241 aa）
Not recorded A1CRO N,N-diethyl-N~2~-hexanoyl-D-asparaginyl-N-{(1S)-2-(2,4-difluorophenyl)-1-[(2S,3S,5S,6S)-5-formyl-2-hydroxy-3-(hydroxymethyl)-3,6-dimethylmorpholin-2-yl]ethyl}-4-fluoro-L-phenylalaninamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.00 Å
9Y1O The structure of the Plasmodium falciparum 20S proteasome Deposited 2025-08-29 Different construct Different mutation/modification Different oligomeric state Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain D 1–241（241 aa）
Chain R 1–241（241 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
9YUY Structure of the Plasmodium falciparum 20S proteasome in complex with a beta5-selective covalent syringolin analogue inhibitor. Deposited 2025-10-23 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain D 1–241（241 aa）
Chain R 1–241（241 aa）
Not recorded A1CY6 methyl N-{[(2R)-1-({(5R,8R)-5-[(3-fluorophenyl)methyl]-2,7-dioxo-1,6-diazacyclododecan-8-yl}amino)-1-oxo-3-phenylpropan-2-yl]carbamoyl}-L-valinate × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.70 Å

13 other PDB entries and 13 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name Q8IDG2_PLAF7
Isoform —
PDB entities 4
Chains and sequence ranges Author chain D； PDBConstruct 1–241； UniProt 1–241

Proteasome subunit alpha type-5

Plasmodium falciparum Dd2

UniProt A0A0L7LVZ5

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 15 PDB declaration: pentadecameric（15） Consistent with protein copy count Chain E； UniProt 1–256 Not recorded Proteasome subunit alpha type-6 × 1 （Q8IAR3） Proteasome subunit alpha type-2 × 1 （C6KST3） Proteasome subunit alpha type-3 × 1 （Q8IDG3） Proteasome subunit alpha type-4 × 1 （Q8IDG2） Proteasome subunit alpha type-1 × 1 （Q8IK90） Proteasome subunit alpha type-3 × 1 （O77396） Proteasome endopeptidase complex × 1 （A0A0L7M1M6） Proteasome subunit beta × 1 （W7K1J4） Proteasome subunit beta-3 × 1 （Q8I261） Proteasome subunit beta-4 × 1 （Q8IKC9） Proteasome subunit beta × 1 （W7K6A8） Proteasome subunit beta × 1 （A0A2I0BU46） Proteasome subunit beta × 1 （A0A0L7LW03） Proteasome maturation factor UMP1 × 1 （W7K992） ELECTRON MICROSCOPY cryo-EM buffer：pH 7.5 cryo-EM vitrification conditions：Cryogen ETHANE Resolution 3.00 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 9Y0L Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
8G6F Structure of the Plasmodium falciparum 20S proteasome beta-6 A117D mutant complexed with inhibitor WLW-vs Deposited 2023-02-15 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain E 1–256（256 aa）
Chain S 1–256（256 aa）
Not recorded 7F1 (2S)-N-[(E,2S)-1-(1H-indol-3-yl)-4-methylsulfonyl-but-3-en-2-yl]-2-[[(2S)-3-(1H-indol-3-yl)-2-(2-morpholin-4-ylethanoylamino)propanoyl]amino]-4-methyl-pentanamide × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.58 Å
9Y0K Structure of Plasmodium falciparum 20S proteasome with bound J80 Deposited 2025-08-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain E 1–256（256 aa）
Chain S 1–256（256 aa）
Not recorded A1CRO N,N-diethyl-N~2~-hexanoyl-D-asparaginyl-N-{(1S)-2-(2,4-difluorophenyl)-1-[(2S,3S,5S,6S)-5-formyl-2-hydroxy-3-(hydroxymethyl)-3,6-dimethylmorpholin-2-yl]ethyl}-4-fluoro-L-phenylalaninamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.00 Å
9Y1O The structure of the Plasmodium falciparum 20S proteasome Deposited 2025-08-29 Different construct Different mutation/modification Different oligomeric state Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain E 1–256（256 aa）
Chain S 1–256（256 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å

3 other PDB entries and 3 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name A0A0L7LVZ5_PLAF4
Isoform —
PDB entities 5
Chains and sequence ranges Author chain E； PDBConstruct 1–256； UniProt 1–256

Proteasome subunit alpha type-1

Plasmodium falciparum Dd2

UniProt Q8IK90

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 15 PDB declaration: pentadecameric（15） Consistent with protein copy count Chain F； UniProt 1–254 Not recorded Proteasome subunit alpha type-6 × 1 （Q8IAR3） Proteasome subunit alpha type-2 × 1 （C6KST3） Proteasome subunit alpha type-3 × 1 （Q8IDG3） Proteasome subunit alpha type-4 × 1 （Q8IDG2） Proteasome subunit alpha type-5 × 1 （A0A0L7LVZ5） Proteasome subunit alpha type-3 × 1 （O77396） Proteasome endopeptidase complex × 1 （A0A0L7M1M6） Proteasome subunit beta × 1 （W7K1J4） Proteasome subunit beta-3 × 1 （Q8I261） Proteasome subunit beta-4 × 1 （Q8IKC9） Proteasome subunit beta × 1 （W7K6A8） Proteasome subunit beta × 1 （A0A2I0BU46） Proteasome subunit beta × 1 （A0A0L7LW03） Proteasome maturation factor UMP1 × 1 （W7K992） ELECTRON MICROSCOPY cryo-EM buffer：pH 7.5 cryo-EM vitrification conditions：Cryogen ETHANE Resolution 3.00 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 9Y0L Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
5FMG Structure and function based design of Plasmodium-selective proteasome inhibitors Deposited 2015-11-04 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain F 1–254（254 aa）
Chain T 1–254（254 aa）
Not recorded 7F1 (2S)-N-[(E,2S)-1-(1H-indol-3-yl)-4-methylsulfonyl-but-3-en-2-yl]-2-[[(2S)-3-(1H-indol-3-yl)-2-(2-morpholin-4-ylethanoylamino)propanoyl]amino]-4-methyl-pentanamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer 50MM TRIS HCL, 5MM MGCL2, 1MM DITHIOTREITOL；pH 7.5；50MM TRIS HCL, 5MM MGCL2, 1MM DITHIOTREITOL
cryo-EM vitrification conditions Cryogen ETHANE；VITRIFICATION 1 -- CRYOGEN- ETHANE, HUMIDITY- 95, INSTRUMENT- FEI VITROBOT MARK III, METHOD- BLOT 2.5 SECONDS BEFORE PLUNGING,
Resolution 3.60 Å
6MUV The structure of the Plasmodium falciparum 20S proteasome in complex with two PA28 activators Deposited 2018-10-23 Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 42 PDB declaration: 42-meric
Chain F 1–254（254 aa）
Chain T 1–254（254 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE；wait time 0sec blot time 2sec blot force -1
Resolution 3.80 Å
6MUW The structure of the Plasmodium falciparum 20S proteasome. Deposited 2018-10-23 Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain F 1–254（254 aa）
Chain T 1–254（254 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE；wait time 0sec blot time 2sec blot force -1
Resolution 3.60 Å
6MUX The structure of the Plasmodium falciparum 20S proteasome in complex with one PA28 activator Deposited 2018-10-23 Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 35 PDB declaration: 35-meric
Chain F 1–254（254 aa）
Chain T 1–254（254 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE；wait time 0sec blot time 2sec blot force -1
Resolution 3.90 Å
7LXT Structure of Plasmodium falciparum 20S proteasome with bound bortezomib Deposited 2021-03-05 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain F 1–254（254 aa）
Chain T 1–254（254 aa）
Not recorded BO2 N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE × 6 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.40 Å
7LXU Structure of Plasmodium falciparum 20S proteasome with bound MPI-5 Deposited 2021-03-05 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain F 1–254（254 aa）
Chain T 1–254（254 aa）
Not recorded YHD N-[(1R)-2-([1,1'-biphenyl]-4-yl)-1-boronoethyl]-1-methyl-L-prolinamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
8G6F Structure of the Plasmodium falciparum 20S proteasome beta-6 A117D mutant complexed with inhibitor WLW-vs Deposited 2023-02-15 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain F 1–254（254 aa）
Chain T 1–254（254 aa）
Not recorded 7F1 (2S)-N-[(E,2S)-1-(1H-indol-3-yl)-4-methylsulfonyl-but-3-en-2-yl]-2-[[(2S)-3-(1H-indol-3-yl)-2-(2-morpholin-4-ylethanoylamino)propanoyl]amino]-4-methyl-pentanamide × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.58 Å
8W2F Plasmodium falciparum 20S proteasome bound to an inhibitor Deposited 2024-02-20 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain F 1–254（254 aa）
Chain T 1–254（254 aa）
Not recorded A1AE6 (3S)-1-[(2-fluoroethoxy)acetyl]-N-{[(4P)-4-(6-methylpyridin-3-yl)-1,3-thiazol-2-yl]methyl}piperidine-3-carboxamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
9O3E Plasmodium falciparum 20S proteasome bound to inhibitor 159 Deposited 2025-04-07 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain F 1–254（254 aa）
Chain T 1–254（254 aa）
Not recorded A1B74 (3S)-N~3~-{(1S)-1-[4-(4-cyanophenyl)-1,3-thiazol-2-yl]ethyl}-N~1~-ethoxypiperidine-1,3-dicarboxamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.79 Å
9O3F Plasmodium falciparum 20S proteasome bound to inhibitor 296 Deposited 2025-04-07 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain F 1–254（254 aa）
Chain T 1–254（254 aa）
Not recorded A1B73 (3S)-1-({[(3S)-piperidin-3-yl]oxy}acetyl)-N-({4-[4-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl}methyl)piperidine-3-carboxamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.28 Å
9Y0K Structure of Plasmodium falciparum 20S proteasome with bound J80 Deposited 2025-08-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain F 1–254（254 aa）
Chain T 1–254（254 aa）
Not recorded A1CRO N,N-diethyl-N~2~-hexanoyl-D-asparaginyl-N-{(1S)-2-(2,4-difluorophenyl)-1-[(2S,3S,5S,6S)-5-formyl-2-hydroxy-3-(hydroxymethyl)-3,6-dimethylmorpholin-2-yl]ethyl}-4-fluoro-L-phenylalaninamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.00 Å
9Y1O The structure of the Plasmodium falciparum 20S proteasome Deposited 2025-08-29 Different construct Different mutation/modification Different oligomeric state Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain F 1–254（254 aa）
Chain T 1–254（254 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
9YUY Structure of the Plasmodium falciparum 20S proteasome in complex with a beta5-selective covalent syringolin analogue inhibitor. Deposited 2025-10-23 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain F 1–254（254 aa）
Chain T 1–254（254 aa）
Not recorded A1CY6 methyl N-{[(2R)-1-({(5R,8R)-5-[(3-fluorophenyl)methyl]-2,7-dioxo-1,6-diazacyclododecan-8-yl}amino)-1-oxo-3-phenylpropan-2-yl]carbamoyl}-L-valinate × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.70 Å

13 other PDB entries and 13 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name Q8IK90_PLAF7
Isoform —
PDB entities 6
Chains and sequence ranges Author chain F； PDBConstruct 1–254； UniProt 1–254

Proteasome subunit alpha type-3

Plasmodium falciparum Dd2

UniProt O77396

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 15 PDB declaration: pentadecameric（15） Consistent with protein copy count Chain G； UniProt 1–252 Not recorded Proteasome subunit alpha type-6 × 1 （Q8IAR3） Proteasome subunit alpha type-2 × 1 （C6KST3） Proteasome subunit alpha type-3 × 1 （Q8IDG3） Proteasome subunit alpha type-4 × 1 （Q8IDG2） Proteasome subunit alpha type-5 × 1 （A0A0L7LVZ5） Proteasome subunit alpha type-1 × 1 （Q8IK90） Proteasome endopeptidase complex × 1 （A0A0L7M1M6） Proteasome subunit beta × 1 （W7K1J4） Proteasome subunit beta-3 × 1 （Q8I261） Proteasome subunit beta-4 × 1 （Q8IKC9） Proteasome subunit beta × 1 （W7K6A8） Proteasome subunit beta × 1 （A0A2I0BU46） Proteasome subunit beta × 1 （A0A0L7LW03） Proteasome maturation factor UMP1 × 1 （W7K992） ELECTRON MICROSCOPY cryo-EM buffer：pH 7.5 cryo-EM vitrification conditions：Cryogen ETHANE Resolution 3.00 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 9Y0L Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
5FMG Structure and function based design of Plasmodium-selective proteasome inhibitors Deposited 2015-11-04 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain G 1–252（252 aa）
Chain U 1–252（252 aa）
Not recorded 7F1 (2S)-N-[(E,2S)-1-(1H-indol-3-yl)-4-methylsulfonyl-but-3-en-2-yl]-2-[[(2S)-3-(1H-indol-3-yl)-2-(2-morpholin-4-ylethanoylamino)propanoyl]amino]-4-methyl-pentanamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer 50MM TRIS HCL, 5MM MGCL2, 1MM DITHIOTREITOL；pH 7.5；50MM TRIS HCL, 5MM MGCL2, 1MM DITHIOTREITOL
cryo-EM vitrification conditions Cryogen ETHANE；VITRIFICATION 1 -- CRYOGEN- ETHANE, HUMIDITY- 95, INSTRUMENT- FEI VITROBOT MARK III, METHOD- BLOT 2.5 SECONDS BEFORE PLUNGING,
Resolution 3.60 Å
6MUV The structure of the Plasmodium falciparum 20S proteasome in complex with two PA28 activators Deposited 2018-10-23 Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 42 PDB declaration: 42-meric
Chain G 1–252（252 aa）
Chain U 1–252（252 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE；wait time 0sec blot time 2sec blot force -1
Resolution 3.80 Å
6MUW The structure of the Plasmodium falciparum 20S proteasome. Deposited 2018-10-23 Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain G 1–252（252 aa）
Chain U 1–252（252 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE；wait time 0sec blot time 2sec blot force -1
Resolution 3.60 Å
6MUX The structure of the Plasmodium falciparum 20S proteasome in complex with one PA28 activator Deposited 2018-10-23 Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 35 PDB declaration: 35-meric
Chain G 1–252（252 aa）
Chain U 1–252（252 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE；wait time 0sec blot time 2sec blot force -1
Resolution 3.90 Å
7LXT Structure of Plasmodium falciparum 20S proteasome with bound bortezomib Deposited 2021-03-05 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain G 1–252（252 aa）
Chain U 1–252（252 aa）
Not recorded BO2 N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE × 6 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.40 Å
7LXU Structure of Plasmodium falciparum 20S proteasome with bound MPI-5 Deposited 2021-03-05 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain G 1–252（252 aa）
Chain U 1–252（252 aa）
Not recorded YHD N-[(1R)-2-([1,1'-biphenyl]-4-yl)-1-boronoethyl]-1-methyl-L-prolinamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
8G6F Structure of the Plasmodium falciparum 20S proteasome beta-6 A117D mutant complexed with inhibitor WLW-vs Deposited 2023-02-15 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain G 1–252（252 aa）
Chain U 1–252（252 aa）
Not recorded 7F1 (2S)-N-[(E,2S)-1-(1H-indol-3-yl)-4-methylsulfonyl-but-3-en-2-yl]-2-[[(2S)-3-(1H-indol-3-yl)-2-(2-morpholin-4-ylethanoylamino)propanoyl]amino]-4-methyl-pentanamide × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.58 Å
8W2F Plasmodium falciparum 20S proteasome bound to an inhibitor Deposited 2024-02-20 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain G 1–252（252 aa）
Chain U 1–252（252 aa）
Not recorded A1AE6 (3S)-1-[(2-fluoroethoxy)acetyl]-N-{[(4P)-4-(6-methylpyridin-3-yl)-1,3-thiazol-2-yl]methyl}piperidine-3-carboxamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
9O3E Plasmodium falciparum 20S proteasome bound to inhibitor 159 Deposited 2025-04-07 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain G 1–252（252 aa）
Chain U 1–252（252 aa）
Not recorded A1B74 (3S)-N~3~-{(1S)-1-[4-(4-cyanophenyl)-1,3-thiazol-2-yl]ethyl}-N~1~-ethoxypiperidine-1,3-dicarboxamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.79 Å
9O3F Plasmodium falciparum 20S proteasome bound to inhibitor 296 Deposited 2025-04-07 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain G 1–252（252 aa）
Chain U 1–252（252 aa）
Not recorded A1B73 (3S)-1-({[(3S)-piperidin-3-yl]oxy}acetyl)-N-({4-[4-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl}methyl)piperidine-3-carboxamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.28 Å
9Y0K Structure of Plasmodium falciparum 20S proteasome with bound J80 Deposited 2025-08-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain G 1–252（252 aa）
Chain U 1–252（252 aa）
Not recorded A1CRO N,N-diethyl-N~2~-hexanoyl-D-asparaginyl-N-{(1S)-2-(2,4-difluorophenyl)-1-[(2S,3S,5S,6S)-5-formyl-2-hydroxy-3-(hydroxymethyl)-3,6-dimethylmorpholin-2-yl]ethyl}-4-fluoro-L-phenylalaninamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.00 Å
9Y1O The structure of the Plasmodium falciparum 20S proteasome Deposited 2025-08-29 Different construct Different mutation/modification Different oligomeric state Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain G 1–252（252 aa）
Chain U 1–252（252 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
9YUY Structure of the Plasmodium falciparum 20S proteasome in complex with a beta5-selective covalent syringolin analogue inhibitor. Deposited 2025-10-23 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain G 1–252（252 aa）
Chain U 1–252（252 aa）
Not recorded A1CY6 methyl N-{[(2R)-1-({(5R,8R)-5-[(3-fluorophenyl)methyl]-2,7-dioxo-1,6-diazacyclododecan-8-yl}amino)-1-oxo-3-phenylpropan-2-yl]carbamoyl}-L-valinate × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.70 Å

13 other PDB entries and 13 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name O77396_PLAF7
Isoform —
PDB entities 7
Chains and sequence ranges Author chain G； PDBConstruct 1–252； UniProt 1–252

Proteasome endopeptidase complex

Plasmodium falciparum Dd2

UniProt A0A0L7M1M6

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 15 PDB declaration: pentadecameric（15） Consistent with protein copy count Chain H； UniProt 1–282 Not recorded Proteasome subunit alpha type-6 × 1 （Q8IAR3） Proteasome subunit alpha type-2 × 1 （C6KST3） Proteasome subunit alpha type-3 × 1 （Q8IDG3） Proteasome subunit alpha type-4 × 1 （Q8IDG2） Proteasome subunit alpha type-5 × 1 （A0A0L7LVZ5） Proteasome subunit alpha type-1 × 1 （Q8IK90） Proteasome subunit alpha type-3 × 1 （O77396） Proteasome subunit beta × 1 （W7K1J4） Proteasome subunit beta-3 × 1 （Q8I261） Proteasome subunit beta-4 × 1 （Q8IKC9） Proteasome subunit beta × 1 （W7K6A8） Proteasome subunit beta × 1 （A0A2I0BU46） Proteasome subunit beta × 1 （A0A0L7LW03） Proteasome maturation factor UMP1 × 1 （W7K992） ELECTRON MICROSCOPY cryo-EM buffer：pH 7.5 cryo-EM vitrification conditions：Cryogen ETHANE Resolution 3.00 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 9Y0L Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
8G6F Structure of the Plasmodium falciparum 20S proteasome beta-6 A117D mutant complexed with inhibitor WLW-vs Deposited 2023-02-15 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain H 31–282（252 aa）
Chain V 31–282（252 aa）
Not recorded 7F1 (2S)-N-[(E,2S)-1-(1H-indol-3-yl)-4-methylsulfonyl-but-3-en-2-yl]-2-[[(2S)-3-(1H-indol-3-yl)-2-(2-morpholin-4-ylethanoylamino)propanoyl]amino]-4-methyl-pentanamide × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.58 Å
9Y0K Structure of Plasmodium falciparum 20S proteasome with bound J80 Deposited 2025-08-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain H 31–282（252 aa）
Chain V 31–282（252 aa）
Not recorded A1CRO N,N-diethyl-N~2~-hexanoyl-D-asparaginyl-N-{(1S)-2-(2,4-difluorophenyl)-1-[(2S,3S,5S,6S)-5-formyl-2-hydroxy-3-(hydroxymethyl)-3,6-dimethylmorpholin-2-yl]ethyl}-4-fluoro-L-phenylalaninamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.00 Å
9Y1O The structure of the Plasmodium falciparum 20S proteasome Deposited 2025-08-29 Different construct Different mutation/modification Different oligomeric state Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain H 31–282（252 aa）
Chain V 31–282（252 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å

3 other PDB entries and 3 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name A0A0L7M1M6_PLAF4
Isoform —
PDB entities 8
Chains and sequence ranges Author chain H； PDBConstruct 1–282； UniProt 1–282

Proteasome subunit beta

Plasmodium falciparum Dd2

UniProt W7K1J4

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 15 PDB declaration: pentadecameric（15） Consistent with protein copy count Chain I； UniProt 1–270 Not recorded Proteasome subunit alpha type-6 × 1 （Q8IAR3） Proteasome subunit alpha type-2 × 1 （C6KST3） Proteasome subunit alpha type-3 × 1 （Q8IDG3） Proteasome subunit alpha type-4 × 1 （Q8IDG2） Proteasome subunit alpha type-5 × 1 （A0A0L7LVZ5） Proteasome subunit alpha type-1 × 1 （Q8IK90） Proteasome subunit alpha type-3 × 1 （O77396） Proteasome endopeptidase complex × 1 （A0A0L7M1M6） Proteasome subunit beta-3 × 1 （Q8I261） Proteasome subunit beta-4 × 1 （Q8IKC9） Proteasome subunit beta × 1 （W7K6A8） Proteasome subunit beta × 1 （A0A2I0BU46） Proteasome subunit beta × 1 （A0A0L7LW03） Proteasome maturation factor UMP1 × 1 （W7K992） ELECTRON MICROSCOPY cryo-EM buffer：pH 7.5 cryo-EM vitrification conditions：Cryogen ETHANE Resolution 3.00 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 9Y0L Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
8G6E Structure of the Plasmodium falciparum 20S proteasome complexed with inhibitor TDI-8304 Deposited 2023-02-15 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain I 42–270（229 aa）
Chain W 42–270（229 aa）
Not recorded YRE (7S,10S,13S)-N-cyclopentyl-10-[2-(morpholin-4-yl)ethyl]-9,12-dioxo-13-(2-oxopyrrolidin-1-yl)-2-oxa-8,11-diazabicyclo[13.3.1]nonadeca-1(19),15,17-triene-7-carboxamide × 6 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.18 Å

1 other PDB entries and 1 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name W7K1J4_PLAFO
Isoform —
PDB entities 9
Chains and sequence ranges Author chain I； PDBConstruct 1–270； UniProt 1–270

Proteasome subunit beta-3

Plasmodium falciparum Dd2

UniProt Q8I261

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 15 PDB declaration: pentadecameric（15） Consistent with protein copy count Chain J； UniProt 1–218 Not recorded Proteasome subunit alpha type-6 × 1 （Q8IAR3） Proteasome subunit alpha type-2 × 1 （C6KST3） Proteasome subunit alpha type-3 × 1 （Q8IDG3） Proteasome subunit alpha type-4 × 1 （Q8IDG2） Proteasome subunit alpha type-5 × 1 （A0A0L7LVZ5） Proteasome subunit alpha type-1 × 1 （Q8IK90） Proteasome subunit alpha type-3 × 1 （O77396） Proteasome endopeptidase complex × 1 （A0A0L7M1M6） Proteasome subunit beta × 1 （W7K1J4） Proteasome subunit beta-4 × 1 （Q8IKC9） Proteasome subunit beta × 1 （W7K6A8） Proteasome subunit beta × 1 （A0A2I0BU46） Proteasome subunit beta × 1 （A0A0L7LW03） Proteasome maturation factor UMP1 × 1 （W7K992） ELECTRON MICROSCOPY cryo-EM buffer：pH 7.5 cryo-EM vitrification conditions：Cryogen ETHANE Resolution 3.00 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 9Y0L Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
5FMG Structure and function based design of Plasmodium-selective proteasome inhibitors Deposited 2015-11-04 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain J 1–204（204 aa）
Chain X 1–204（204 aa）
Not recorded 7F1 (2S)-N-[(E,2S)-1-(1H-indol-3-yl)-4-methylsulfonyl-but-3-en-2-yl]-2-[[(2S)-3-(1H-indol-3-yl)-2-(2-morpholin-4-ylethanoylamino)propanoyl]amino]-4-methyl-pentanamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer 50MM TRIS HCL, 5MM MGCL2, 1MM DITHIOTREITOL；pH 7.5；50MM TRIS HCL, 5MM MGCL2, 1MM DITHIOTREITOL
cryo-EM vitrification conditions Cryogen ETHANE；VITRIFICATION 1 -- CRYOGEN- ETHANE, HUMIDITY- 95, INSTRUMENT- FEI VITROBOT MARK III, METHOD- BLOT 2.5 SECONDS BEFORE PLUNGING,
Resolution 3.60 Å
6MUV The structure of the Plasmodium falciparum 20S proteasome in complex with two PA28 activators Deposited 2018-10-23 Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 42 PDB declaration: 42-meric
Chain J 1–218（218 aa）
Chain X 1–218（218 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE；wait time 0sec blot time 2sec blot force -1
Resolution 3.80 Å
6MUW The structure of the Plasmodium falciparum 20S proteasome. Deposited 2018-10-23 Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain J 1–218（218 aa）
Chain X 1–218（218 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE；wait time 0sec blot time 2sec blot force -1
Resolution 3.60 Å
6MUX The structure of the Plasmodium falciparum 20S proteasome in complex with one PA28 activator Deposited 2018-10-23 Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 35 PDB declaration: 35-meric
Chain J 1–218（218 aa）
Chain X 1–218（218 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE；wait time 0sec blot time 2sec blot force -1
Resolution 3.90 Å
7LXT Structure of Plasmodium falciparum 20S proteasome with bound bortezomib Deposited 2021-03-05 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain J 1–218（218 aa）
Chain X 1–218（218 aa）
Not recorded BO2 N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE × 6 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.40 Å
7LXU Structure of Plasmodium falciparum 20S proteasome with bound MPI-5 Deposited 2021-03-05 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain J 1–218（218 aa）
Chain X 1–218（218 aa）
Not recorded YHD N-[(1R)-2-([1,1'-biphenyl]-4-yl)-1-boronoethyl]-1-methyl-L-prolinamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
8G6F Structure of the Plasmodium falciparum 20S proteasome beta-6 A117D mutant complexed with inhibitor WLW-vs Deposited 2023-02-15 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain J 1–218（218 aa）
Chain X 1–218（218 aa）
Not recorded 7F1 (2S)-N-[(E,2S)-1-(1H-indol-3-yl)-4-methylsulfonyl-but-3-en-2-yl]-2-[[(2S)-3-(1H-indol-3-yl)-2-(2-morpholin-4-ylethanoylamino)propanoyl]amino]-4-methyl-pentanamide × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.58 Å
8W2F Plasmodium falciparum 20S proteasome bound to an inhibitor Deposited 2024-02-20 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain J 1–218（218 aa）
Chain X 1–218（218 aa）
Not recorded A1AE6 (3S)-1-[(2-fluoroethoxy)acetyl]-N-{[(4P)-4-(6-methylpyridin-3-yl)-1,3-thiazol-2-yl]methyl}piperidine-3-carboxamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
9O3E Plasmodium falciparum 20S proteasome bound to inhibitor 159 Deposited 2025-04-07 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain J 1–218（218 aa）
Chain X 1–218（218 aa）
Not recorded A1B74 (3S)-N~3~-{(1S)-1-[4-(4-cyanophenyl)-1,3-thiazol-2-yl]ethyl}-N~1~-ethoxypiperidine-1,3-dicarboxamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.79 Å
9O3F Plasmodium falciparum 20S proteasome bound to inhibitor 296 Deposited 2025-04-07 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain J 1–218（218 aa）
Chain X 1–218（218 aa）
Not recorded A1B73 (3S)-1-({[(3S)-piperidin-3-yl]oxy}acetyl)-N-({4-[4-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl}methyl)piperidine-3-carboxamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.28 Å
9Y0K Structure of Plasmodium falciparum 20S proteasome with bound J80 Deposited 2025-08-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain J 1–218（218 aa）
Chain X 1–218（218 aa）
Not recorded A1CRO N,N-diethyl-N~2~-hexanoyl-D-asparaginyl-N-{(1S)-2-(2,4-difluorophenyl)-1-[(2S,3S,5S,6S)-5-formyl-2-hydroxy-3-(hydroxymethyl)-3,6-dimethylmorpholin-2-yl]ethyl}-4-fluoro-L-phenylalaninamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.00 Å
9Y1O The structure of the Plasmodium falciparum 20S proteasome Deposited 2025-08-29 Different construct Different mutation/modification Different oligomeric state Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain J 1–218（218 aa）
Chain X 1–218（218 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
9YUY Structure of the Plasmodium falciparum 20S proteasome in complex with a beta5-selective covalent syringolin analogue inhibitor. Deposited 2025-10-23 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain J 1–218（218 aa）
Chain X 1–218（218 aa）
Not recorded A1CY6 methyl N-{[(2R)-1-({(5R,8R)-5-[(3-fluorophenyl)methyl]-2,7-dioxo-1,6-diazacyclododecan-8-yl}amino)-1-oxo-3-phenylpropan-2-yl]carbamoyl}-L-valinate × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.70 Å

13 other PDB entries and 13 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name Q8I261_PLAF7
Isoform —
PDB entities 10
Chains and sequence ranges Author chain J； PDBConstruct 1–218； UniProt 1–218

Proteasome subunit beta-4

Plasmodium falciparum Dd2

UniProt Q8IKC9

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 15 PDB declaration: pentadecameric（15） Consistent with protein copy count Chain K； UniProt 1–195 Not recorded Proteasome subunit alpha type-6 × 1 （Q8IAR3） Proteasome subunit alpha type-2 × 1 （C6KST3） Proteasome subunit alpha type-3 × 1 （Q8IDG3） Proteasome subunit alpha type-4 × 1 （Q8IDG2） Proteasome subunit alpha type-5 × 1 （A0A0L7LVZ5） Proteasome subunit alpha type-1 × 1 （Q8IK90） Proteasome subunit alpha type-3 × 1 （O77396） Proteasome endopeptidase complex × 1 （A0A0L7M1M6） Proteasome subunit beta × 1 （W7K1J4） Proteasome subunit beta-3 × 1 （Q8I261） Proteasome subunit beta × 1 （W7K6A8） Proteasome subunit beta × 1 （A0A2I0BU46） Proteasome subunit beta × 1 （A0A0L7LW03） Proteasome maturation factor UMP1 × 1 （W7K992） ELECTRON MICROSCOPY cryo-EM buffer：pH 7.5 cryo-EM vitrification conditions：Cryogen ETHANE Resolution 3.00 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 9Y0L Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
5FMG Structure and function based design of Plasmodium-selective proteasome inhibitors Deposited 2015-11-04 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain K 1–195（195 aa）
Chain Y 1–195（195 aa）
Not recorded 7F1 (2S)-N-[(E,2S)-1-(1H-indol-3-yl)-4-methylsulfonyl-but-3-en-2-yl]-2-[[(2S)-3-(1H-indol-3-yl)-2-(2-morpholin-4-ylethanoylamino)propanoyl]amino]-4-methyl-pentanamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer 50MM TRIS HCL, 5MM MGCL2, 1MM DITHIOTREITOL；pH 7.5；50MM TRIS HCL, 5MM MGCL2, 1MM DITHIOTREITOL
cryo-EM vitrification conditions Cryogen ETHANE；VITRIFICATION 1 -- CRYOGEN- ETHANE, HUMIDITY- 95, INSTRUMENT- FEI VITROBOT MARK III, METHOD- BLOT 2.5 SECONDS BEFORE PLUNGING,
Resolution 3.60 Å
6MUV The structure of the Plasmodium falciparum 20S proteasome in complex with two PA28 activators Deposited 2018-10-23 Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 42 PDB declaration: 42-meric
Chain K 1–195（195 aa）
Chain Y 1–195（195 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE；wait time 0sec blot time 2sec blot force -1
Resolution 3.80 Å
6MUW The structure of the Plasmodium falciparum 20S proteasome. Deposited 2018-10-23 Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain K 1–195（195 aa）
Chain Y 1–195（195 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE；wait time 0sec blot time 2sec blot force -1
Resolution 3.60 Å
6MUX The structure of the Plasmodium falciparum 20S proteasome in complex with one PA28 activator Deposited 2018-10-23 Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 35 PDB declaration: 35-meric
Chain K 1–195（195 aa）
Chain Y 1–195（195 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE；wait time 0sec blot time 2sec blot force -1
Resolution 3.90 Å
7LXT Structure of Plasmodium falciparum 20S proteasome with bound bortezomib Deposited 2021-03-05 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain K 1–195（195 aa）
Chain Y 1–195（195 aa）
Not recorded BO2 N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE × 6 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.40 Å
7LXU Structure of Plasmodium falciparum 20S proteasome with bound MPI-5 Deposited 2021-03-05 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain K 1–195（195 aa）
Chain Y 1–195（195 aa）
Not recorded YHD N-[(1R)-2-([1,1'-biphenyl]-4-yl)-1-boronoethyl]-1-methyl-L-prolinamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
8G6F Structure of the Plasmodium falciparum 20S proteasome beta-6 A117D mutant complexed with inhibitor WLW-vs Deposited 2023-02-15 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain K 1–195（195 aa）
Chain Y 1–195（195 aa）
Not recorded 7F1 (2S)-N-[(E,2S)-1-(1H-indol-3-yl)-4-methylsulfonyl-but-3-en-2-yl]-2-[[(2S)-3-(1H-indol-3-yl)-2-(2-morpholin-4-ylethanoylamino)propanoyl]amino]-4-methyl-pentanamide × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.58 Å
8W2F Plasmodium falciparum 20S proteasome bound to an inhibitor Deposited 2024-02-20 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain K 1–195（195 aa）
Chain Y 1–195（195 aa）
Not recorded A1AE6 (3S)-1-[(2-fluoroethoxy)acetyl]-N-{[(4P)-4-(6-methylpyridin-3-yl)-1,3-thiazol-2-yl]methyl}piperidine-3-carboxamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
9O3E Plasmodium falciparum 20S proteasome bound to inhibitor 159 Deposited 2025-04-07 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain K 1–195（195 aa）
Chain Y 1–195（195 aa）
Not recorded A1B74 (3S)-N~3~-{(1S)-1-[4-(4-cyanophenyl)-1,3-thiazol-2-yl]ethyl}-N~1~-ethoxypiperidine-1,3-dicarboxamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.79 Å
9O3F Plasmodium falciparum 20S proteasome bound to inhibitor 296 Deposited 2025-04-07 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain K 1–195（195 aa）
Chain Y 1–195（195 aa）
Not recorded A1B73 (3S)-1-({[(3S)-piperidin-3-yl]oxy}acetyl)-N-({4-[4-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl}methyl)piperidine-3-carboxamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.28 Å
9Y0K Structure of Plasmodium falciparum 20S proteasome with bound J80 Deposited 2025-08-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain K 1–195（195 aa）
Chain Y 1–195（195 aa）
Not recorded A1CRO N,N-diethyl-N~2~-hexanoyl-D-asparaginyl-N-{(1S)-2-(2,4-difluorophenyl)-1-[(2S,3S,5S,6S)-5-formyl-2-hydroxy-3-(hydroxymethyl)-3,6-dimethylmorpholin-2-yl]ethyl}-4-fluoro-L-phenylalaninamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.00 Å
9Y1O The structure of the Plasmodium falciparum 20S proteasome Deposited 2025-08-29 Different construct Different mutation/modification Different oligomeric state Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain K 1–195（195 aa）
Chain Y 1–195（195 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
9YUY Structure of the Plasmodium falciparum 20S proteasome in complex with a beta5-selective covalent syringolin analogue inhibitor. Deposited 2025-10-23 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain K 1–195（195 aa）
Chain Y 1–195（195 aa）
Not recorded A1CY6 methyl N-{[(2R)-1-({(5R,8R)-5-[(3-fluorophenyl)methyl]-2,7-dioxo-1,6-diazacyclododecan-8-yl}amino)-1-oxo-3-phenylpropan-2-yl]carbamoyl}-L-valinate × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.70 Å

13 other PDB entries and 13 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name Q8IKC9_PLAF7
Isoform —
PDB entities 11
Chains and sequence ranges Author chain K； PDBConstruct 1–195； UniProt 1–195

Proteasome subunit beta

Plasmodium falciparum Dd2

UniProt W7K6A8

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 15 PDB declaration: pentadecameric（15） Consistent with protein copy count Chain L； UniProt 1–271 Not recorded Proteasome subunit alpha type-6 × 1 （Q8IAR3） Proteasome subunit alpha type-2 × 1 （C6KST3） Proteasome subunit alpha type-3 × 1 （Q8IDG3） Proteasome subunit alpha type-4 × 1 （Q8IDG2） Proteasome subunit alpha type-5 × 1 （A0A0L7LVZ5） Proteasome subunit alpha type-1 × 1 （Q8IK90） Proteasome subunit alpha type-3 × 1 （O77396） Proteasome endopeptidase complex × 1 （A0A0L7M1M6） Proteasome subunit beta × 1 （W7K1J4） Proteasome subunit beta-3 × 1 （Q8I261） Proteasome subunit beta-4 × 1 （Q8IKC9） Proteasome subunit beta × 1 （A0A2I0BU46） Proteasome subunit beta × 1 （A0A0L7LW03） Proteasome maturation factor UMP1 × 1 （W7K992） ELECTRON MICROSCOPY cryo-EM buffer：pH 7.5 cryo-EM vitrification conditions：Cryogen ETHANE Resolution 3.00 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 9Y0L Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
8G6E Structure of the Plasmodium falciparum 20S proteasome complexed with inhibitor TDI-8304 Deposited 2023-02-15 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain L 61–271（211 aa）
Chain Z 61–271（211 aa）
Not recorded YRE (7S,10S,13S)-N-cyclopentyl-10-[2-(morpholin-4-yl)ethyl]-9,12-dioxo-13-(2-oxopyrrolidin-1-yl)-2-oxa-8,11-diazabicyclo[13.3.1]nonadeca-1(19),15,17-triene-7-carboxamide × 6 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.18 Å

1 other PDB entries and 1 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name W7K6A8_PLAFO
Isoform —
PDB entities 12
Chains and sequence ranges Author chain L； PDBConstruct 1–271； UniProt 1–271

Proteasome subunit beta

Plasmodium falciparum Dd2

UniProt A0A2I0BU46

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 15 PDB declaration: pentadecameric（15） Consistent with protein copy count Chain M； UniProt 1–240 Not recorded Proteasome subunit alpha type-6 × 1 （Q8IAR3） Proteasome subunit alpha type-2 × 1 （C6KST3） Proteasome subunit alpha type-3 × 1 （Q8IDG3） Proteasome subunit alpha type-4 × 1 （Q8IDG2） Proteasome subunit alpha type-5 × 1 （A0A0L7LVZ5） Proteasome subunit alpha type-1 × 1 （Q8IK90） Proteasome subunit alpha type-3 × 1 （O77396） Proteasome endopeptidase complex × 1 （A0A0L7M1M6） Proteasome subunit beta × 1 （W7K1J4） Proteasome subunit beta-3 × 1 （Q8I261） Proteasome subunit beta-4 × 1 （Q8IKC9） Proteasome subunit beta × 1 （W7K6A8） Proteasome subunit beta × 1 （A0A0L7LW03） Proteasome maturation factor UMP1 × 1 （W7K992） ELECTRON MICROSCOPY cryo-EM buffer：pH 7.5 cryo-EM vitrification conditions：Cryogen ETHANE Resolution 3.00 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 9Y0L Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
8G6E Structure of the Plasmodium falciparum 20S proteasome complexed with inhibitor TDI-8304 Deposited 2023-02-15 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain M 1–240（240 aa）
Chain a 1–240（240 aa）
Not recorded YRE (7S,10S,13S)-N-cyclopentyl-10-[2-(morpholin-4-yl)ethyl]-9,12-dioxo-13-(2-oxopyrrolidin-1-yl)-2-oxa-8,11-diazabicyclo[13.3.1]nonadeca-1(19),15,17-triene-7-carboxamide × 6 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.18 Å
8G6F Structure of the Plasmodium falciparum 20S proteasome beta-6 A117D mutant complexed with inhibitor WLW-vs Deposited 2023-02-15 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain M 1–240（240 aa）
Chain a 1–240（240 aa）
Mutation：A117D Mutation：A117D 7F1 (2S)-N-[(E,2S)-1-(1H-indol-3-yl)-4-methylsulfonyl-but-3-en-2-yl]-2-[[(2S)-3-(1H-indol-3-yl)-2-(2-morpholin-4-ylethanoylamino)propanoyl]amino]-4-methyl-pentanamide × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.58 Å
9Y0K Structure of Plasmodium falciparum 20S proteasome with bound J80 Deposited 2025-08-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain M 1–240（240 aa）
Chain a 1–240（240 aa）
Not recorded A1CRO N,N-diethyl-N~2~-hexanoyl-D-asparaginyl-N-{(1S)-2-(2,4-difluorophenyl)-1-[(2S,3S,5S,6S)-5-formyl-2-hydroxy-3-(hydroxymethyl)-3,6-dimethylmorpholin-2-yl]ethyl}-4-fluoro-L-phenylalaninamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.00 Å
9Y1O The structure of the Plasmodium falciparum 20S proteasome Deposited 2025-08-29 Different construct Different mutation/modification Different oligomeric state Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain M 1–240（240 aa）
Chain a 1–240（240 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å

4 other PDB entries and 4 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name A0A2I0BU46_PLAFO
Isoform —
PDB entities 13
Chains and sequence ranges Author chain M； PDBConstruct 1–240； UniProt 1–240

Proteasome subunit beta

Plasmodium falciparum Dd2

UniProt A0A0L7LW03

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 15 PDB declaration: pentadecameric（15） Consistent with protein copy count Chain N； UniProt 1–265 Not recorded Proteasome subunit alpha type-6 × 1 （Q8IAR3） Proteasome subunit alpha type-2 × 1 （C6KST3） Proteasome subunit alpha type-3 × 1 （Q8IDG3） Proteasome subunit alpha type-4 × 1 （Q8IDG2） Proteasome subunit alpha type-5 × 1 （A0A0L7LVZ5） Proteasome subunit alpha type-1 × 1 （Q8IK90） Proteasome subunit alpha type-3 × 1 （O77396） Proteasome endopeptidase complex × 1 （A0A0L7M1M6） Proteasome subunit beta × 1 （W7K1J4） Proteasome subunit beta-3 × 1 （Q8I261） Proteasome subunit beta-4 × 1 （Q8IKC9） Proteasome subunit beta × 1 （W7K6A8） Proteasome subunit beta × 1 （A0A2I0BU46） Proteasome maturation factor UMP1 × 1 （W7K992） ELECTRON MICROSCOPY cryo-EM buffer：pH 7.5 cryo-EM vitrification conditions：Cryogen ETHANE Resolution 3.00 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 9Y0L Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
8G6F Structure of the Plasmodium falciparum 20S proteasome beta-6 A117D mutant complexed with inhibitor WLW-vs Deposited 2023-02-15 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain N 1–265（265 aa）
Chain b 1–265（265 aa）
Not recorded 7F1 (2S)-N-[(E,2S)-1-(1H-indol-3-yl)-4-methylsulfonyl-but-3-en-2-yl]-2-[[(2S)-3-(1H-indol-3-yl)-2-(2-morpholin-4-ylethanoylamino)propanoyl]amino]-4-methyl-pentanamide × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.58 Å
9Y1O The structure of the Plasmodium falciparum 20S proteasome Deposited 2025-08-29 Different construct Different mutation/modification Different oligomeric state Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric
Chain N 1–265（265 aa）
Chain b 1–265（265 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å

2 other PDB entries and 2 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name A0A0L7LW03_PLAF4
Isoform —
PDB entities 14
Chains and sequence ranges Author chain N； PDBConstruct 1–265； UniProt 1–265

Proteasome maturation factor UMP1

Plasmodium falciparum Dd2

UniProt W7K992

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 15 PDB declaration: pentadecameric（15） Consistent with protein copy count Chain e； UniProt 1–124 Not recorded Proteasome subunit alpha type-6 × 1 （Q8IAR3） Proteasome subunit alpha type-2 × 1 （C6KST3） Proteasome subunit alpha type-3 × 1 （Q8IDG3） Proteasome subunit alpha type-4 × 1 （Q8IDG2） Proteasome subunit alpha type-5 × 1 （A0A0L7LVZ5） Proteasome subunit alpha type-1 × 1 （Q8IK90） Proteasome subunit alpha type-3 × 1 （O77396） Proteasome endopeptidase complex × 1 （A0A0L7M1M6） Proteasome subunit beta × 1 （W7K1J4） Proteasome subunit beta-3 × 1 （Q8I261） Proteasome subunit beta-4 × 1 （Q8IKC9） Proteasome subunit beta × 1 （W7K6A8） Proteasome subunit beta × 1 （A0A2I0BU46） Proteasome subunit beta × 1 （A0A0L7LW03） ELECTRON MICROSCOPY cryo-EM buffer：pH 7.5 cryo-EM vitrification conditions：Cryogen ETHANE Resolution 3.00 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

No other PDB entry for the same UniProt protein was found.

View Construct and Data Evidence
UniProt name W7K992_PLAFO
Isoform —
PDB entities 15
Chains and sequence ranges Author chain e； PDBConstruct 1–124； UniProt 1–124

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

SAXS scattering curve SAXS Profile

SAXS profile for 9y0l

P(r) Distance Distribution P(r) Distribution

P(r) distribution for 9y0l
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▼

2. Structure Basics 2. Structure Basics

Entry ID entry_id9y0l
Deposition date deposition_date2025-08-28
Structure title titleIncorrectly assembled half-Pf20S
Keywords keywordsProteasome, 20S proteasome, Plasmodium falciparum, HYDROLASE; HYDROLASE
Experimental Method methodELECTRON MICROSCOPY
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3. SAXS Parameters (CRYSOL theoretical calculation) 3. SAXS Parameters (CRYSOL)

Radius of gyration Rg (Guinier) rg_guinier44.56 Å
Radius of gyration Rg (electron density) rg_electron43.87 Å
Forward intensity I(0) i01660220000.00
Molecular weight molecular_weight346740.0 kDa
Excluded volume excluded_volume436780 ų
Envelope volume envelope_volume573630 ų
Hydration-shell volume shell_volume101700 ų
Envelope diameter envelope_diameter139.0 Å
Shell Rg shell_rg53.71 Å
Envelope Rg envelope_rg43.40 Å
Shape Rg shape_rg43.86 Å
Total Rg total_rg44.27 Å
Total atoms total_atoms24452
Residues n_residues3206
Spherical-harmonic order n_harmonics20
q range q_range— – 0.5000 Å−1
Data points n_points101
Shell type shell_typedirectional
Solvent electron density solvent_density0.3340 e/ų
Shell contrast contrast_shell0.0300 e/ų
CRYSOL version crysol_version4.1.3
▼

4. P(r) Distance Distribution (GNOM inversion) 4. P(r) Analysis (GNOM)

Maximum dimension Dmax dmax136.9 Å
Rg (real space) rg_real44.23 Å
Rg uncertainty (real space) rg_real_error0.76 Å
I(0) (real space) i0_real1.6600e+09
I(0) uncertainty (real space) i0_real_error2.5740e+07
Rg (reciprocal space) rg_reciprocal44.56 Å
I(0) (reciprocal space) i0_reciprocal1661000000.0000
Solution quality estimate total_estimate0.8927
Solution quality rating solution_quality GOOD a GOOD solution
P(r) peaks n_peaks1
Primary peak position r_peak_primary58.7 Å
Skewness Skewness skewness0.058
Kurtosis Kurtosis kurtosis-0.533
Angular range angular_range— – 0.1750 Å−1
Current regularization parameter α current_alpha0.0000
Highest regularization parameter α highest_alpha285000000.0000
Real-space data points n_real_points36
GNOM version gnom_version4.1.3
Quality Criteria quality_criteria AN1: 0.000; Oscil: 0.908; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.960; Smooth: 0.917
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5. Crystallography and Experiment 5. Crystallography & Experiment

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6. Entities and Polymers Entities & Polymers (15)

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8. Citations (1)

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9. Files and Curves (10)