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8izn

Structural study of Interferon-induced, double-stranded RNA-activated protein kinase (PKR) and Non-structural protein 1 (NS1) complex

Method: ELECTRON MICROSCOPY
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Interferon-induced, double-stranded RNA-activated protein kinase

Homo sapiens

UniProt P19525

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 2 Non-structural protein 1 × 1 （Q463W9） Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1qu6 3uiu 3uiu

3 assemblies

Homodimer
6d3k 6d3k 6d3l 6d3l

4 assemblies

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
2a19 2a1a 6npy 7obk 7obl 8bi7 8i9j 8izn 8qel

9 assemblies

View Construct and Data Evidence
UniProt name E2AK2_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 6–175； UniProt 1–170

Non-structural protein 1

Influenza A virus (strain A/Memphis/102/1972 H3N2)

UniProt Q463W9

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 2 Interferon-induced, double-stranded RNA-activated protein kinase × 1 （P19525） Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
8izn

1 assemblies

View Construct and Data Evidence
UniProt name NS1_I72A3
Isoform —
PDB entities 2
Chains and sequence ranges Author chain B； PDBConstruct 1–122； UniProt 84–205

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id8izn
Deposition date deposition_date2023-04-07
Last revision last_revision2024-04-10
Structure title titleStructural study of Interferon-induced, double-stranded RNA-activated protein kinase (PKR) and Non-structural protein 1 (NS1) complex
Keywords keywordsPKR, NS1, PKR and NS1 complex, VIRUS, TRANSFERASE-VIRAL PROTEIN complex; TRANSFERASE/VIRAL PROTEIN
Experimental Method methodELECTRON MICROSCOPY
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

8izn__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

8izn__assembly_1__model_1 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

8izn__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）31.35 Å
Rg (electron density)31.13 Å
Total Rg31.31 Å
Atom count3727
Residues301
Excluded volume41849 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 8izn__assembly_1__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (2)

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7. Citations (1)