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8vhg

Structure of the BMAL1/HIF2A heterodimer in Complex with DNA

Method: ELECTRON MICROSCOPY
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Endothelial PAS domain-containing protein 1

Mus musculus

UniProt P97481

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–DNA Heteromer Protein 2 DNA 2 Basic helix-loop-helix ARNT-like protein 1 × 1 （Q9WTL8） Reverse strand DNA containing HRE motif × 1 Forward strand DNA containing HRE motif × 1 Consistent with all polymers

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
4zp4 4zp4 4zph 4zph 4zpk 4zqd 4zqd 6e3s 6e3t 6e3u 7w80 8vhg

16 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name EPAS1_MOUSE
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 22–380； UniProt 3–361

Basic helix-loop-helix ARNT-like protein 1

Mus musculus

UniProt Q9WTL8

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–DNA Heteromer Protein 2 DNA 2 Endothelial PAS domain-containing protein 1 × 1 （P97481） Reverse strand DNA containing HRE motif × 1 Forward strand DNA containing HRE motif × 1 Consistent with all polymers

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
8osj 8osk 8osl 8vhg

4 assemblies

View Construct and Data Evidence
UniProt name BMAL1_MOUSE
Isoform —
PDB entities 2
Chains and sequence ranges Author chain B； PDBConstruct 1–421； UniProt 75–494

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id8vhg
Deposition date deposition_date2024-01-01
Structure title titleStructure of the BMAL1/HIF2A heterodimer in Complex with DNA
Keywords keywordsTranscriptional factors, heterodimer, DNA recognition, Circadian-dependent cardioprotection, TRANSCRIPTION-DNA complex; TRANSCRIPTION/DNA
Experimental Method methodELECTRON MICROSCOPY
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

8vhg__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

8vhg__assembly_1__model_1 | I(q)

10-2 10-1 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

8vhg__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）35.15 Å
Rg (electron density)33.73 Å
Total Rg34.16 Å
Atom count4719
Residues548
Excluded volume81451 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 8vhg__assembly_1__model_1 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (4)

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7. Citations (1)