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9k6g

Structure of human LINE-1 ORF2p with endogenous dsDNA and RNA/cDNA hybrid

Method: ELECTRON MICROSCOPY
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1. Protein Identity and Related Structures Protein Identity & Related Structures

LINE-1 retrotransposable element ORF2 protein

Homo sapiens

UniProt O00370

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Other combination Monomer Protein 1 DNA 3 RNA 1 Genomic DNA (top strand) × 1 Complementary DNA × 1 Genomic DNA (bottom strand) × 1 Template RNA × 1 ZINC ION × 1 Consistent with all polymers

Other States of the Same Protein in the Database

Monomer
7n8k 7n8k

2 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
7n8s 7n94 7n94 8sxt 8sxu 8uw3 9hdo 9hdp 9hdq 9hdr 9k6g 9k6h

13 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name LORF2_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–1274； UniProt 2–1275

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id9k6g
Deposition date deposition_date2024-10-22
Last revision last_revision2025-10-22
Structure title titleStructure of human LINE-1 ORF2p with endogenous dsDNA and RNA/cDNA hybrid
Keywords keywordsEndonuclease, Reverse transcriptase, GENE REGULATION; GENE REGULATION
Experimental Method methodELECTRON MICROSCOPY
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

9k6g__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

9k6g__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

9k6g__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）35.17 Å
Rg (electron density)34.62 Å
Total Rg35.23 Å
Atom count9620
Residues1082
Excluded volume170330 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 9k6g__assembly_1__model_1 pentameric （5） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (6)

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7. Citations (1)