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9q6z

Human Serum Albumin in complex with four nanobodies: N33, nb139, nb39 & nb104

Method: ELECTRON MICROSCOPY D_max: 128.1 Å Quality: REASONABLE

SAXS Profile

P(r) Distribution

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1. Structure Basics

entry_id	9q6z
deposition_date	2025-08-22
title	Human Serum Albumin in complex with four nanobodies: N33, nb139, nb39 & nb104
keywords	Nanobody, VHH, IMMUNE SYSTEM; IMMUNE SYSTEM
method	ELECTRON MICROSCOPY

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Download Data

SAXS curve (.dat) P(r) distribution (.pr.out) Structure (CIF)

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2. SAXS Parameters (CRYSOL)

rg_guinier	37.97 Å
rg_electron	37.44 Å
i0	236990000.00
molecular_weight	121700.0 kDa
excluded_volume	151040 Å³
envelope_volume	201210 Å³
shell_volume	45934 Å³
envelope_diameter	140.6 Å
shell_rg	42.10 Å
envelope_rg	37.27 Å
shape_rg	37.45 Å
total_rg	37.70 Å
total_atoms	16805
n_residues	1093
n_harmonics	20
q_range	— – 0.5000 Å⁻¹
n_points	101
shell_type	directional
solvent_density	0.3340 e/Å³
contrast_shell	0.0300 e/Å³
crysol_version	4.1.3

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3. P(r) Analysis (GNOM)

dmax	128.1 Å
rg_real	37.96 Å
rg_real_error	0.96 Å
i0_real	2.3700e+08
i0_real_error	3.6700e+06
rg_reciprocal	37.97 Å
i0_reciprocal	237000000.0000
total_estimate	0.6678
solution_quality	REASONABLE a REASONABLE solution
n_peaks	2
r_peak_primary	45.8 Å
skewness	0.279
kurtosis	-0.441
angular_range	— – 0.2100 Å⁻¹
current_alpha	0.0000
highest_alpha	20830000.0000
n_real_points	43
gnom_version	4.1.3
quality_criteria	AN1: 0.000; Oscil: 0.895; Stabil: 1.000; Sysdev: 0.020; Positv: 1.000; Valcen: 0.994; Smooth: 0.939

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4. Crystallography & Experiment

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5. Entities & Polymer Info (5)

Entity 1 polymer

description	Serum albumin
formula_weight	66571.2 kDa
src_method	man
entity_count	1

Polymer

type	polypeptide(L)
strand_id	A
atom_count	16805

DAHKSEVAHRFKDLGEENFKALVLIAFAQYLQQCPFEDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTVATLRETYGEMADCCAKQEPERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLFFAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAVARLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLKECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYARRHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFEQLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVVLNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTLSEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLVAASQAALGL

Source

organism	Homo sapiens
common_name	human
ncbi_taxonomy_id	9606
host_organism	Homo sapiens

Entity 2 polymer

description	N33
formula_weight	14461.0 kDa
src_method	man
entity_count	1

Polymer

type	polypeptide(L)
strand_id	B

HVQLVESGGGLVQAGGSLRLSCAASDTIDNYARAWFRQAPGKEREFVAAITWTFGTPYYTDSVKGRFTISRDDAKNTVYLQMNSLKPEDTAVYYCAASLYLPVRTASGGYRLDTDRPQYWGQGTQVTVSSE

Source

organism	Lama glama
ncbi_taxonomy_id	9844
host_organism	Escherichia coli

Entity 3 polymer

description	nb139
formula_weight	13725.2 kDa
src_method	man
entity_count	1

Polymer

type	polypeptide(L)
strand_id	C

AQVQLVESGGGAVQAGGSLQLSCRASGRTFSPYVMGWFRQAPGKEREFVGLITWSGGTSYADSVRGRFTASRDRVKNTVYLQMNSLKPEDTAVYYCAAAYGAGYYVHERQYDYWGQGTQVTVSEP

Source

organism	Lama glama
ncbi_taxonomy_id	9844
host_organism	Escherichia coli

Entity 4 polymer

description	nb39
formula_weight	13773.2 kDa
src_method	man
entity_count	1

Polymer

type	polypeptide(L)
strand_id	D

AHVQLVESGGGLVQAGGSLRVSCAASGREFSNYGMGWFRQAPGKEREFVATISWNGRITFYADSVKGRFTISRDNAEKTGYLQMNSLKPEDTALYYCAAETSGWGSKVVPNYDYWGQGTQVTVSEP

Source

organism	Lama glama
ncbi_taxonomy_id	9844
host_organism	Escherichia coli

Entity 5 polymer

description	nb104
formula_weight	13404.8 kDa
src_method	man
entity_count	1

Polymer

type	polypeptide(L)
strand_id	E

AEVQLVESGGGLAQAGGSLRLSCAASGRTFSNSCMGWFRQAPGKEREFVATIRSTGHASYADSVEGRFTVSRDIAKNTVYLEMNSLKPDDTAVYICGAGVSDYGCYRTSGYNSWGQGTQVTVSEPK

Source

organism	Lama glama
ncbi_taxonomy_id	9844
host_organism	Escherichia coli

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6. Citations (1)

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length_a	1.000 Å
length_b	1.000 Å
length_c	1.000 Å
angle_alpha	90.00 °
angle_beta	90.00 °
angle_gamma	90.00 °
z_pdb	—

space_group	P 1
int_tables_number	1
crystal_system	—

resolution	3.700 Å
resolution_low	— Å
r_factor	—
r_work	—
r_free	—

resolution	3.70 Å
resolution_method	—
num_particles	291872

fit	/app/data/saxs_computation/q6/9q6z/9q6z.fit
pddf	/app/data/pr_computation/q6/9q6z/9q6z.pr.out
profile	/app/data/saxs_computation/q6/9q6z/9q6z.dat

Human Serum Albumin in complex with four nanobodies: N33, nb139, nb39 & nb104

SAXS Profile

P(r) Distribution

1. Structure Basics

Download Data

2. SAXS Parameters (CRYSOL)

3. P(r) Analysis (GNOM)

4. Crystallography & Experiment

Unit Cell

Symmetry

Refinement

EM 3D

5. Entities & Polymer Info (5)

Entity 1 polymer

Polymer

Source

Entity 2 polymer

Polymer

Source

Entity 3 polymer

Polymer

Source

Entity 4 polymer

Polymer

Source

Entity 5 polymer

Polymer

Source

6. Citations (1)

7. Files & Curves (10)

Files (7)

Curves (3)