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9r07

Cryo-EM structure of rat SLCO2A1 bound to zafirlukast.

Method: ELECTRON MICROSCOPY D_max: 91.9 Å Quality: GOOD

SAXS Profile

P(r) Distribution

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1. Structure Basics

entry_id	9r07
deposition_date	2025-04-24
title	Cryo-EM structure of rat SLCO2A1 bound to zafirlukast.
keywords	OATP2A1, plasma membrane localised, prostaglandin transporter, PGT, major facilitator superfamily., MEMBRANE PROTEIN; MEMBRANE PROTEIN
method	ELECTRON MICROSCOPY

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Download Data

SAXS curve (.dat) P(r) distribution (.pr.out) Structure (CIF)

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2. SAXS Parameters (CRYSOL)

rg_guinier	28.90 Å
rg_electron	27.38 Å
i0	56695600.00
molecular_weight	62932.0 kDa
excluded_volume	80516 Å³
envelope_volume	102740 Å³
shell_volume	31593 Å³
envelope_diameter	96.8 Å
shell_rg	34.52 Å
envelope_rg	27.76 Å
shape_rg	27.34 Å
total_rg	28.30 Å
total_atoms	4425
n_residues	565
n_harmonics	20
q_range	— – 0.5000 Å⁻¹
n_points	101
shell_type	directional
solvent_density	0.3340 e/Å³
contrast_shell	0.0300 e/Å³
crysol_version	4.1.3

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3. P(r) Analysis (GNOM)

dmax	91.9 Å
rg_real	28.94 Å
rg_real_error	0.60 Å
i0_real	5.6700e+07
i0_real_error	8.8030e+05
rg_reciprocal	28.92 Å
i0_reciprocal	56700000.0000
total_estimate	0.8917
solution_quality	GOOD a GOOD solution
n_peaks	2
r_peak_primary	33.4 Å
skewness	0.362
kurtosis	-0.358
angular_range	— – 0.2750 Å⁻¹
current_alpha	0.0000
highest_alpha	7479000.0000
n_real_points	56
gnom_version	4.1.3
quality_criteria	AN1: 0.000; Oscil: 0.942; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.972; Smooth: 0.788

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4. Crystallography & Experiment

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5. Entities & Polymer Info (3)

Entity 1 polymer

description	Solute carrier organic anion transporter family member 2A1
formula_weight	72615.1 kDa
src_method	man
entity_count	1

Polymer

type	polypeptide(L)
strand_id	A
atom_count	4425

MGLLLKPGARQGSGTSSVPDRRCPRSVFSNIKVFVLCHGLLQLCQLLYSAYFKSSLTTIEKRFGLSSSSSGLISSLNEISNATLIIFISYFGSRVNRPRMIGIGGLLLAAGAFVLTLPHFLSEPYQYTSTTDGNRSSFQTDLCQKHFGALPPSKCHSTVPDTHKETSSLWGLMVVAQLLAGIGTVPIQPFGISYVDDFAEPTNSPLYISILFAIAVFGPAFGYLLGSVMLRIFVDYGRVDTATVNLSPGDPRWIGAWWLGLLISSGFLIVTSLPFFFFPRAMSRGAERSVTAEETMQTEEDKSRGSLMDFIKRFPRIFLRLLMNPLFMLVVLSQCTFSSVIAGLSTFLNKFLEKQYGATAAYANFLIGAVNLPAAALGMLFGGILMKRFVFPLQTIPRVAATIITISMILCVPLFFMGCSTSAVAEVYPPSTSSSIHPQQPPACRRDCSCPDSFFHPVCGDNGVEYVSPCHAGCSSTNTSSEASKEPIYLNCSCVSGGSASAKTGSCPTSCAQLLLPSIFLISFAALIACISHNPLYMMVLRVVNQDEKSFAIGVQFLLMRLLAWLPAPSLYGLLIDSSCVRWNYLCSGRRGACAYYDNDALRNRYLGLQMVYKALGTLLLFFISWRMKKNREYSLQENTSGLIGLNDIFEAQKIEWHELEGG

Source

organism	Rattus norvegicus
common_name	Norway rat
ncbi_taxonomy_id	10116
host_organism	Homo sapiens

Entity 2 non-polymer

description	zafirlukast
formula_weight	575.7 kDa
src_method	syn
entity_count	1

Entity 3 non-polymer

description	CHOLESTEROL HEMISUCCINATE
formula_weight	486.7 kDa
src_method	syn
entity_count	1

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6. Citations (1)

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length_a	1.000 Å
length_b	1.000 Å
length_c	1.000 Å
angle_alpha	90.00 °
angle_beta	90.00 °
angle_gamma	90.00 °
z_pdb	—

space_group	P 1
int_tables_number	1
crystal_system	—

resolution	3.200 Å
resolution_low	— Å
r_factor	—
r_work	—
r_free	—

resolution	3.20 Å
resolution_method	—
num_particles	146876

fit	/app/data/saxs_computation/r0/9r07/9r07.fit
pddf	/app/data/pr_computation/r0/9r07/9r07.pr.out
profile	/app/data/saxs_computation/r0/9r07/9r07.dat

Cryo-EM structure of rat SLCO2A1 bound to zafirlukast.

SAXS Profile

P(r) Distribution

1. Structure Basics

Download Data

2. SAXS Parameters (CRYSOL)

3. P(r) Analysis (GNOM)

4. Crystallography & Experiment

Unit Cell

Symmetry

Refinement

EM 3D