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9r0n

Cryo-EM structure of rat SLCO2A1 bound to dinoprost.

Method: ELECTRON MICROSCOPY D_max: 93.7 Å Quality: GOOD

SAXS Profile

P(r) Distribution

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1. Structure Basics

entry_id	9r0n
deposition_date	2025-04-24
title	Cryo-EM structure of rat SLCO2A1 bound to dinoprost.
keywords	OATP2A1, plasma membrane localized, prostaglandin transporter, PGT, major facilitator superfamily., MEMBRANE PROTEIN; MEMBRANE PROTEIN
method	ELECTRON MICROSCOPY

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Download Data

SAXS curve (.dat) P(r) distribution (.pr.out) Structure (CIF)

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2. SAXS Parameters (CRYSOL)

rg_guinier	28.61 Å
rg_electron	27.13 Å
i0	52385900.00
molecular_weight	60954.0 kDa
excluded_volume	78216 Å³
envelope_volume	99343 Å³
shell_volume	30913 Å³
envelope_diameter	92.3 Å
shell_rg	34.16 Å
envelope_rg	27.44 Å
shape_rg	27.10 Å
total_rg	28.02 Å
total_atoms	4287
n_residues	549
n_harmonics	20
q_range	— – 0.5000 Å⁻¹
n_points	101
shell_type	directional
solvent_density	0.3340 e/Å³
contrast_shell	0.0300 e/Å³
crysol_version	4.1.3

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3. P(r) Analysis (GNOM)

dmax	93.7 Å
rg_real	28.63 Å
rg_real_error	0.75 Å
i0_real	5.2390e+07
i0_real_error	7.5210e+05
rg_reciprocal	28.62 Å
i0_reciprocal	52390000.0000
total_estimate	0.8944
solution_quality	GOOD a GOOD solution
n_peaks	1
r_peak_primary	32.4 Å
skewness	0.347
kurtosis	-0.397
angular_range	— – 0.2750 Å⁻¹
current_alpha	0.0000
highest_alpha	7016000.0000
n_real_points	56
gnom_version	4.1.3
quality_criteria	AN1: 0.000; Oscil: 0.914; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.952; Smooth: 0.929

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4. Crystallography & Experiment

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5. Entities & Polymer Info (3)

Entity 1 polymer

description	Solute carrier organic anion transporter family member 2A1
formula_weight	72615.1 kDa
src_method	man
entity_count	1

Polymer

type	polypeptide(L)
strand_id	A
atom_count	4287

MGLLLKPGARQGSGTSSVPDRRCPRSVFSNIKVFVLCHGLLQLCQLLYSAYFKSSLTTIEKRFGLSSSSSGLISSLNEISNATLIIFISYFGSRVNRPRMIGIGGLLLAAGAFVLTLPHFLSEPYQYTSTTDGNRSSFQTDLCQKHFGALPPSKCHSTVPDTHKETSSLWGLMVVAQLLAGIGTVPIQPFGISYVDDFAEPTNSPLYISILFAIAVFGPAFGYLLGSVMLRIFVDYGRVDTATVNLSPGDPRWIGAWWLGLLISSGFLIVTSLPFFFFPRAMSRGAERSVTAEETMQTEEDKSRGSLMDFIKRFPRIFLRLLMNPLFMLVVLSQCTFSSVIAGLSTFLNKFLEKQYGATAAYANFLIGAVNLPAAALGMLFGGILMKRFVFPLQTIPRVAATIITISMILCVPLFFMGCSTSAVAEVYPPSTSSSIHPQQPPACRRDCSCPDSFFHPVCGDNGVEYVSPCHAGCSSTNTSSEASKEPIYLNCSCVSGGSASAKTGSCPTSCAQLLLPSIFLISFAALIACISHNPLYMMVLRVVNQDEKSFAIGVQFLLMRLLAWLPAPSLYGLLIDSSCVRWNYLCSGRRGACAYYDNDALRNRYLGLQMVYKALGTLLLFFISWRMKKNREYSLQENTSGLIGLNDIFEAQKIEWHELEGG

Source

organism	Rattus norvegicus
common_name	Norway rat
ncbi_taxonomy_id	10116
host_organism	Homo sapiens

Entity 2 non-polymer

description	(Z)-7-[(1R,2R,3R,5S)-3,5-bis(oxidanyl)-2-[(E,3S)-3-oxidanyloct-1-enyl]cyclopentyl]hept-5-enoic acid
formula_weight	354.5 kDa
src_method	syn
entity_count	1

Entity 3 non-polymer

description	CHOLESTEROL HEMISUCCINATE
formula_weight	486.7 kDa
src_method	syn
entity_count	1

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6. Citations (1)

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length_a	1.000 Å
length_b	1.000 Å
length_c	1.000 Å
angle_alpha	90.00 °
angle_beta	90.00 °
angle_gamma	90.00 °
z_pdb	—

space_group	P 1
int_tables_number	1
crystal_system	—

resolution	3.400 Å
resolution_low	— Å
r_factor	—
r_work	—
r_free	—

resolution	3.40 Å
resolution_method	—
num_particles	206784

fit	/app/data/saxs_computation/r0/9r0n/9r0n.fit
pddf	/app/data/pr_computation/r0/9r0n/9r0n.pr.out
profile	/app/data/saxs_computation/r0/9r0n/9r0n.dat

Cryo-EM structure of rat SLCO2A1 bound to dinoprost.

SAXS Profile

P(r) Distribution

1. Structure Basics

Download Data

2. SAXS Parameters (CRYSOL)

3. P(r) Analysis (GNOM)

4. Crystallography & Experiment

Unit Cell

Symmetry

Refinement

EM 3D