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9r0a

Cryo-EM structure of rat SLCO2A1 bound to fentiazac.

Method: ELECTRON MICROSCOPY D_max: 91.8 Å Quality: GOOD

SAXS Profile

P(r) Distribution

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1. Structure Basics

entry_id	9r0a
deposition_date	2025-04-24
title	Cryo-EM structure of rat SLCO2A1 bound to fentiazac.
keywords	OATP2A1, plasma membrane localised, prostaglandin transporter, PGT, major facilitator superfamily., MEMBRANE PROTEIN; MEMBRANE PROTEIN
method	ELECTRON MICROSCOPY

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Download Data

SAXS curve (.dat) P(r) distribution (.pr.out) Structure (CIF)

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2. SAXS Parameters (CRYSOL)

rg_guinier	28.24 Å
rg_electron	27.30 Å
i0	114830000.00
molecular_weight	58328.0 kDa
excluded_volume	57414 Å³
envelope_volume	101570 Å³
shell_volume	31502 Å³
envelope_diameter	96.7 Å
shell_rg	34.17 Å
envelope_rg	27.60 Å
shape_rg	27.22 Å
total_rg	27.97 Å
total_atoms	4416
n_residues	561
n_harmonics	20
q_range	— – 0.5000 Å⁻¹
n_points	101
shell_type	directional
solvent_density	0.3340 e/Å³
contrast_shell	0.0300 e/Å³
crysol_version	4.1.3

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3. P(r) Analysis (GNOM)

dmax	91.8 Å
rg_real	28.28 Å
rg_real_error	0.67 Å
i0_real	1.1480e+08
i0_real_error	1.6360e+06
rg_reciprocal	28.27 Å
i0_reciprocal	114800000.0000
total_estimate	0.8926
solution_quality	GOOD a GOOD solution
n_peaks	2
r_peak_primary	32.8 Å
skewness	0.381
kurtosis	-0.306
angular_range	— – 0.2800 Å⁻¹
current_alpha	0.0000
highest_alpha	10100000.0000
n_real_points	57
gnom_version	4.1.3
quality_criteria	AN1: 0.000; Oscil: 0.908; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.979; Smooth: 0.897

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4. Crystallography & Experiment

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5. Entities & Polymer Info (3)

Entity 1 polymer

description	Solute carrier organic anion transporter family member 2A1
formula_weight	72615.1 kDa
src_method	man
entity_count	1

Polymer

type	polypeptide(L)
strand_id	A
atom_count	4416

MGLLLKPGARQGSGTSSVPDRRCPRSVFSNIKVFVLCHGLLQLCQLLYSAYFKSSLTTIEKRFGLSSSSSGLISSLNEISNATLIIFISYFGSRVNRPRMIGIGGLLLAAGAFVLTLPHFLSEPYQYTSTTDGNRSSFQTDLCQKHFGALPPSKCHSTVPDTHKETSSLWGLMVVAQLLAGIGTVPIQPFGISYVDDFAEPTNSPLYISILFAIAVFGPAFGYLLGSVMLRIFVDYGRVDTATVNLSPGDPRWIGAWWLGLLISSGFLIVTSLPFFFFPRAMSRGAERSVTAEETMQTEEDKSRGSLMDFIKRFPRIFLRLLMNPLFMLVVLSQCTFSSVIAGLSTFLNKFLEKQYGATAAYANFLIGAVNLPAAALGMLFGGILMKRFVFPLQTIPRVAATIITISMILCVPLFFMGCSTSAVAEVYPPSTSSSIHPQQPPACRRDCSCPDSFFHPVCGDNGVEYVSPCHAGCSSTNTSSEASKEPIYLNCSCVSGGSASAKTGSCPTSCAQLLLPSIFLISFAALIACISHNPLYMMVLRVVNQDEKSFAIGVQFLLMRLLAWLPAPSLYGLLIDSSCVRWNYLCSGRRGACAYYDNDALRNRYLGLQMVYKALGTLLLFFISWRMKKNREYSLQENTSGLIGLNDIFEAQKIEWHELEGG

Source

organism	Rattus norvegicus
common_name	Norway rat
ncbi_taxonomy_id	10116
host_organism	Homo sapiens

Entity 2 non-polymer

description	2-[4-(4-chlorophenyl)-2-phenyl-1,3-thiazol-5-yl]ethanoic acid
formula_weight	329.8 kDa
src_method	syn
entity_count	1

Entity 3 non-polymer

description	Lauryl Maltose Neopentyl Glycol
formula_weight	1005.2 kDa
src_method	syn
entity_count	1

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6. Citations (1)

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length_a	1.000 Å
length_b	1.000 Å
length_c	1.000 Å
angle_alpha	90.00 °
angle_beta	90.00 °
angle_gamma	90.00 °
z_pdb	—

space_group	P 1
int_tables_number	1
crystal_system	—

resolution	3.100 Å
resolution_low	— Å
r_factor	—
r_work	—
r_free	—

resolution	3.10 Å
resolution_method	—
num_particles	54096

fit	/app/data/saxs_computation/r0/9r0a/9r0a.fit
pddf	/app/data/pr_computation/r0/9r0a/9r0a.pr.out
profile	/app/data/saxs_computation/r0/9r0a/9r0a.dat

Cryo-EM structure of rat SLCO2A1 bound to fentiazac.

SAXS Profile

P(r) Distribution

1. Structure Basics

Download Data

2. SAXS Parameters (CRYSOL)

3. P(r) Analysis (GNOM)

4. Crystallography & Experiment

Unit Cell

Symmetry

Refinement

EM 3D