Structure of ARGX-121 Fab fragment in complex with the Fc fragment of IgA1

entry_id	9r2e
deposition_date	2025-04-30
last_revision	2025-05-14
title	Structure of ARGX-121 Fab fragment in complex with the Fc fragment of IgA1
keywords	Antibody, immune system, IgA mediated autoimmunity, immunoglobulin, PROTEROS BIOSTRUCTURES GMBH; IMMUNE SYSTEM
method	X-RAY DIFFRACTION

rg_guinier	48.93 Å
rg_electron	50.11 Å
i0	286749000.00
molecular_weight	137470.0 kDa
excluded_volume	171460 ų
envelope_volume	250300 ų
shell_volume	47226 ų
envelope_diameter	187.3 Å
shell_rg	45.26 Å
envelope_rg	50.30 Å
shape_rg	50.04 Å
total_rg	50.11 Å
total_atoms	9665
n_residues	1283
n_harmonics	20
q_range	— – 0.5000 Å−1
n_points	101
shell_type	directional
solvent_density	0.3340 e/ų
contrast_shell	0.0300 e/ų
crysol_version	4.1.3

dmax	176.0 Å
rg_real	49.92 Å
rg_real_error	2.31 Å
i0_real	2.8670e+08
i0_real_error	5.3650e+06
rg_reciprocal	48.94 Å
i0_reciprocal	286400000.0000
total_estimate	0.5274
solution_quality	REASONABLE a REASONABLE solution
n_peaks	2
r_peak_primary	38.5 Å
skewness	0.643
kurtosis	-0.116
angular_range	— – 0.1600 Å−1
current_alpha	0.0000
highest_alpha	17180000.0000
n_real_points	33
gnom_version	4.1.3
quality_criteria	AN1: 0.000; Oscil: 0.650; Stabil: 1.000; Sysdev: 0.013; Positv: 1.000; Valcen: 0.528; Smooth: 0.335

Unit Cell

length_a	77.291 Å
length_b	232.312 Å
length_c	105.519 Å
angle_alpha	90.00 °
angle_beta	90.35 °
angle_gamma	90.00 °
z_pdb	8

Symmetry

space_group	C 1 2 1
int_tables_number	5
crystal_system	—

Refinement

resolution	2.540 Å
resolution_low	116.160 Å
r_factor	0.2131
r_work	0.2109
r_free	0.2518

Diffraction

temperature

100.0 K

Files (7)

• pr_distribution /app/data/pr_computation/r2/9r2e/pr_distribution.json
• pr_output /app/data/pr_computation/r2/9r2e/9r2e.pr.out
• pr_plot /app/data/visualization/pr_computation/r2/9r2e/9r2e_pr_distribution.png
• saxs_curve_dat /app/data/saxs_computation/r2/9r2e/9r2e.dat
• saxs_fit /app/data/saxs_computation/r2/9r2e/9r2e.fit
• saxs_log /app/data/saxs_computation/r2/9r2e/9r2e.log
• saxs_plot /app/data/visualization/saxs_computation/r2/9r2e/9r2e_saxs_profile.png

Curves (3)

fit	/app/data/saxs_computation/r2/9r2e/9r2e.fit
pddf	/app/data/pr_computation/r2/9r2e/9r2e.pr.out
profile	/app/data/saxs_computation/r2/9r2e/9r2e.dat